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Literature for peptidase C19.035: ubiquitin-specific peptidase 22

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Literature Inhibitors

(Topics flags: T Target, P Specificity, I Inhibitor, K Knockout, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Chen,H., Liu,J., Zhang,J., Chen,Y., Wang,Y., Qiu,Y., Hu,H., Chai,L., Zhang,Q., Wang,Q. and Li,M.
    USP22/BRD4 mediated hedgehog pathway activation contributes to airway remodeling in asthma
    Int Immunopharmacol (2025) 153, 114538-114538. PubMed  Europe PubMed DOI
  2. Ling,H., Xiao,S., Lei,Y., Zhou,Y., Tan,J., Chen,X., Ma,D., Liang,C., Liu,Q., Liu,W. and Zeng,T.
    The advancement of ubiquitination regulation in apoptosis, ferroptosis, autophagy, drug resistance and treatment of cancer
    Arch Biochem Biophys (2025) 771, 110497-110497. PubMed  Europe PubMed DOI  V
  3. Luo,Y., Zhou,F., Chen,Q., Cai,H., Yao,K. and Deng,X.
    Knockdown of PATZ1 alleviates chronic heart failure through the USP22/HIF-1alpha axis
    Sci Rep (2025) 15, 40566-40566. PubMed  Europe PubMed DOI  PMC  EPMC  K
  4. Peng,Z., Huang,X., Pan,Y., Li,W., Hu,H., Chen,X., Zhang,Z., Hu,J., Qi,Y., Chen,W., Cui,X., Liu,H., Liang,W., Ding,G. and Chen,Z.
    USP22 promotes angiotensin II-induced podocyte injury by deubiquitinating and stabilizing HMGB1
    Cell Signal (2025) 131, 111771-111771. PubMed  Europe PubMed DOI
  5. Tang,S., Lu,C., Meng,Z., Ye,Z., Qin,Y., Na,N., Xian,S., Huang,F. and Zeng,Z.
    USP22 enhances atherosclerotic plaque stability and macrophage efferocytosis by stabilizing PPARgamma
    Commun Biol (2025) 8, 678-678. PubMed  Europe PubMed DOI  PMC  EPMC
  6. Xiao,X., Li,S., Zheng,Z., Ji,Y., Du,Q., Zuo,Y., Miao,Y., Yuan,Y., Zheng,H., Huang,F. and Wang,J.
    Targeting USP22 to promote K63-linked ubiquitination and degradation of SARS-CoV-2 nucleocapsid protein
    J Virol (2025) , e0223424-e0223424. PubMed  Europe PubMed DOI
  7. Yang,H., Sun,T., Sun,Z., Wang,H., Liu,D., Wu,D., Qin,T. and Zhou,M.
    Unravelling the role of ubiquitin-specific proteases in breast carcinoma: insights into tumour progression and immune microenvironment modulation
    World J Surg Oncol (2025) 23, 60-60. PubMed  Europe PubMed DOI  PMC  EPMC  V
    8. 2024
  8. Chen,G., Du,D., Wang,H. and Li,H.
    The Deubiquitinase USP22-Stabilized COL17A1 Promotes Lung Adenocarcinoma Progression
    Clin Respir J (2024) 18, e13824-e13824. PubMed  Europe PubMed DOI  PMC  EPMC  K
  9. Chen,S., Hu,X., Yi,X., Deng,X., Xiong,T., Ou,Y., Liu,S., Li,C., Yan,X. and Hao,L.
    USP22 Promotes Osteosarcoma Progression by Stabilising beta-Catenin and Upregulating HK2 and Glycolysis
    J Cell Mol Med (2024) 28, e70239-e70239. PubMed  Europe PubMed DOI  PMC  EPMC
  10. Huang,J., Yin,Q., Wang,Y., Zhou,X., Guo,Y., Tang,Y., Cheng,R., Yu,X., Zhang,J., Huang,C., Huang,Z., Zhang,J., Guo,Z., Huo,X., Sun,Y., Li,Y., Wang,H., Yang,J. and Xue,L.
    EZH2 Inhibition Enhances PD-L1 Protein Stability Through USP22-Mediated Deubiquitination in Colorectal Cancer
    Adv Sci (Weinh) (2024) , e2308045-e2308045. PubMed  Europe PubMed DOI
  11. Kowald,L., Roedig,J., Karlowitz,R., Wagner,K., Smith,S., Juretschke,T., Beli,P., Muller,S. and van Wijk,S.J.L.
    USP22 regulates APL differentiation via PML-RARalpha stabilization and IFN repression
    Cell Death Discov (2024) 10, 128-128. PubMed  Europe PubMed DOI  PMC  EPMC
  12. Kuang,X., Salinger,A., Benavides,F., Muller,W.J., Dent,S.Y.R. and Koutelou,E.
    USP22 overexpression fails to augment tumor formation in MMTV-ERBB2 mice but loss of function impacts MMTV promoter activity
    PLoS ONE (2024) 19, e0290837-e0290837. PubMed  Europe PubMed DOI  PMC  EPMC
  13. Liu,J., Wang,Y., Zhang,S., Sun,L. and Shi,Y.
    ADAM9 deubiquitination induced by USP22 suppresses proliferation, migration, invasion, and epithelial-mesenchymal transition of trophoblast cells in preeclampsia
    Placenta (2024) 146, 50-57. PubMed  Europe PubMed DOI
  14. Liu,K., Gao,Q., Jia,Y., Wei,J., Chaudhuri,S.M., Wang,S., Tang,A., Mani,N.L., Iyer,R., Cheng,Y., Gao,B., Lu,W., Sun,Z., Zhang,B., Liu,H. and Fang,D.
    Ubiquitin-specific peptidase 22 controls integrin-dependent cancer cell stemness and metastasis
    iScience (2024) 27, 110592-110592. PubMed  Europe PubMed DOI  PMC  EPMC
  15. Lu,W., Chu,P., Tang,A., Si,L. and Fang,D.
    The secoiridoid glycoside Gentiopicroside is a USP22 inhibitor with potent antitumor immunotherapeutic activity
    Biomed Pharmacother (2024) 177, 116974-116974. PubMed  Europe PubMed DOI  I
  16. Prokakis,E., Bamahmoud,H., Jansari,S., Fritsche,L., Dietz,A., Boshnakovska,A., Rehling,P., Johnsen,S.A., Gallwas,J. and Wegwitz,F.
    USP22 supports the aggressive behavior of basal-like breast cancer by stimulating cellular respiration
    Cell Commun Signal (2024) 22, 120-120. PubMed  Europe PubMed DOI  PMC  EPMC
  17. Qian,L., Li,B., Pi,L., Fang,B. and Meng,X.
    Hypoxic adipose stem cell-derived exosomes carrying high-abundant USP22 facilitate cutaneous wound healing through stabilizing HIF-1alpha and upregulating lncRNA H19
    FASEB J (2024) 38, e23653-e23653. PubMed  Europe PubMed DOI
  18. Sun,H., Meng,Y., Yao,L., Du,S., Li,Y., Zhou,Q., Liu,Y., Dian,Y., Sun,Y., Wang,X., Liang,X.W., Deng,G., Chen,X. and Zeng,F.
    Ubiquitin-specific protease 22 controls melanoma metastasis and vulnerability to ferroptosis through targeting SIRT1/PTEN/PI3K signaling
    MedComm (2020) (2024) 5, e684-e684. PubMed  Europe PubMed DOI  PMC  EPMC
  19. Tang,Y., Wang,T., Gu,L., Xu,Y., Yang,Z., Zhu,W., Zhang,Q., Luo,J., Cao,J. and Jiao,Y.
    USP11 Exacerbates Radiation-Induced Pneumonitis by Activating Endothelial Cell Inflammatory Response via OTUD5-STING Signaling
    Int J Radiat Oncol Biol Phys (2024) 119, 1261-1274. PubMed  Europe PubMed DOI  I
  20. Xue,Y., Xue,C. and Song,W.
    Emerging roles of deubiquitinating enzymes in actin cytoskeleton and tumor metastasis
    Cell Oncol (Dordr) (2024) PubMed  Europe PubMed DOI  V
  21. Yin,Z., Zhang,X., Sun,X., Huo,Y., Ji,N. and Chen,K.
    Mogrol-Mediated enhancement of radiotherapy sensitivity in Non-Small cell lung cancer: A mechanistic study
    Am J Physiol Cell Physiol (2024) 326, C1753-C1768. PubMed  Europe PubMed DOI
  22. Yu,M.C., Li,X.L., Ning,M.L., Yan,Z.Z. and Yu,W.T.
    USP22 Inhibits Microglial M1 Polarization by Regulating the PU.1/NLRP3 Inflammasome Pathway
    Brain Res Bull (2024) , 111157-111157. PubMed  Europe PubMed DOI  K
  23. Zeng,M., Yang,Y., Wang,Z., Zhao,X., Zhu,D., Wang,M., Chen,Y. and Wei,X.
    CTRP9 prevents atherosclerosis progression through changing autophagic status of macrophages by activating USP22 mediated-de-ubiquitination on Sirt1 in vitro
    Mol Cell Endocrinol (2024) 584, 112161-112161. PubMed  Europe PubMed DOI
  24. Zhang,Q., Zhu,J., Xie,J., Gu,Y. and Chen,L.
    USP22 as a key regulator of glycolysis pathway in osteosarcoma: insights from bioinformatics and experimental approaches
    PeerJ (2024) 12, e17397-e17397. PubMed  Europe PubMed DOI  PMC  EPMC  K
  25. Zhao,X., Wang,S., He,X., Wei,W. and Huang,K.
    Quercetin prevents the USP22-Snail1 signaling pathway to ameliorate diabetic tubulointerstitial fibrosis
    Food Funct (2024) PubMed  Europe PubMed DOI
  26. Zhen,F., Sun,Y., Wang,H., Liu,W., Liang,X., Wang,Y., Wang,Q. and Hu,J.
    Ubiquitin-Specific Protease 22 Plays a Key Role in Increasing Extracellular Vesicle Secretion and Regulating Cell Motility of Lung Adenocarcinoma
    Adv Sci (Weinh) (2024) , e2405731-e2405731. PubMed  Europe PubMed DOI
  27. Zhou,M., Gao,Y., Wu,S., Wang,Y. and Yang,J.
    USP22 is required for human endometrial stromal cell proliferation and decidualization by deubiquitinating FoxM1
    Cell Signal (2024) , 111265-111265. PubMed  Europe PubMed DOI
  28. Zhou,Y., Chu,P., Wang,Y., Li,N., Gao,Q., Wang,S., Wei,J., Xue,G., Zhao,Y., Jia,H., Song,J., Zhang,Y., Pang,Y., Zhu,H., Sun,J., Ma,S., Su,C., Hu,B., Zhao,Z., Zhang,H., Lu,J., Wang,J., Wang,H., Sun,Z. and Fang,D.
    Epinephrine promotes breast cancer metastasis through a ubiquitin-specific peptidase 22-mediated lipolysis circuit
    Sci Adv (2024) 10, eado1533-eado1533. PubMed  Europe PubMed DOI  PMC  EPMC
    29. 2023
  29. Apoorva,C.C., Ananthaneni,A., Kumar,A.J., Guduru,V.S. and Puneeth,H.K.
    Evaluation of USP22 and Ki-67 expression in oral squamous cell carcinoma: An immunohistochemical study
    J Oral Maxillofac Pathol (2023) 27, 679-684. PubMed  Europe PubMed DOI  PMC  EPMC
  30. Friebus-Kardash,J., Christ,T.C., Dietlein,N., Elwy,A., Abdelrahman,H., Holnsteiner,L., Hu,Z., Rodewald,H.R. and Lang,K.S.
    Usp22 Deficiency Leads to Downregulation of PD-L1 and Pathological Activation of CD8(+) T Cells and Causes Immunopathology in Response to Acute LCMV Infection
    Vaccines (Basel) (2023) 11 PubMed  Europe PubMed DOI  PMC  EPMC
  31. Han,X., Yin,M., Gong,C., Zhang,C., Zhu,G., Hu,M., Tan,K., Jiang,L., Wang,G. and Li,L.
    A1BG-AS1 promotes the biological functions of osteosarcoma cells via regulating the microRNA-148a-3p/USP22 axis and stabilizing the expression of SIRT1 through deubiquitinase function
    Expert Opin Ther Targets (2023) 27, 1017-1029. PubMed  Europe PubMed DOI  K
  32. Jiang,Y.N., Yang,S.X., Guan,X., Chen,Q., Zhao,L., Yu,X.Y., Ren,F.F., Wu,S.J., Wu,L.P., Lai,T.F. and Li,L.
    Loss of USP22 alleviates cardiac hypertrophy induced by pressure overload through HiF1-alpha-TAK1 signaling pathway
    Biochim Biophys Acta Mol Basis Dis (2023) 1869, 166813-166813. PubMed  Europe PubMed DOI
  33. Li,Y., Gao,J., Liu,C., Bu,N., Zhan,S., Wu,H., Zhang,R., Sun,H. and Fan,H.
    USP22 knockdown protects against cerebral ischemia/reperfusion injury via destabilizing PTEN protein and activating the mTOR/TFEB pathway
    Naunyn Schmiedebergs Arch Pharmacol (2023) 396, 3163-3175. PubMed  Europe PubMed DOI
  34. Liu,K., Gao,Q., Jia,Y., Wei,J., Chaudhuri,S., Wang,S., Tang,A., Mani,N., Iyer,R., Cheng,Y., Gao,B., Lu,W., Sun,Z., Liu,H. and Fang,D.
    Ubiquitin-specific peptidase 22 controls integrin-dependent cancer cell stemness and metastasis
    Res Sq (2023) PubMed  Europe PubMed DOI  PMC  EPMC
  35. Liu,K., Gao,Q., Jia,Y., Wei,J., Chaudhuri,S., Wang,S., Tang,A., Mani,N., Iyer,R., Cheng,Y., Gao,B., Lu,W., Sun,Z., Liu,H. and Fang,D.
    Ubiquitin-specific peptidase 22 controls integrin-dependent cancer cell stemness and metastasis
    Res Sq (2023) PubMed  Europe PubMed DOI  PMC  EPMC
  36. Ye,Q., Zhou,W., Xu,S., Que,Q., Zhan,Q., Zhang,L., Zheng,S., Ling,S. and Xu,X.
    Ubiquitin-specific protease 22 promotes tumorigenesis and progression by an FKBP12/mTORC1/autophagy positive feedback loop in hepatocellular carcinoma
    MedComm (2020) (2023) 4, e439-e439. PubMed  Europe PubMed DOI  PMC  EPMC
  37. Zeng,K., Xie,W., Wang,C., Wang,S., Liu,W., Su,Y., Lin,L., Zou,R., Sun,G., Zhou,B., Wang,M., Luan,R., Bai,Y., Huo,Y., Kato,S., Zhong,X. and Zhao,Y.
    USP22 upregulates ZEB1-mediated VEGFA transcription in hepatocellular carcinoma
    Cell Death Dis (2023) 14, 194-194. PubMed  Europe PubMed DOI  PMC  EPMC  K
  38. Zhang,K., Sun,T., Li,W., Guo,Y., Li,A., Hsieh,M., Wang,J., Wu,J., Arvanitis,L. and Raz,D.J.
    Inhibition of USP7 upregulates USP22 and activates its downstream cancer-related signaling pathways in human cancer cells
    Cell Commun Signal (2023) 21, 319-319. PubMed  Europe PubMed DOI  PMC  EPMC  K
  39. Zhang,Y., Song,J., Zhou,Y., Jia,H., Zhou,T., Sun,Y., Gao,Q., Zhao,Y., Pan,Y., Sun,Z. and Chu,P.
    Discovery of selective and potent USP22 inhibitors via structure-based virtual screening and bioassays exerting anti-tumor activity
    Bioorg Chem (2023) 141, 106842-106842. PubMed  Europe PubMed DOI
  40. Zhao,X., He,X., Wei,W. and Huang,K.
    USP22 aggravated diabetic renal tubulointerstitial fibrosis progression through deubiquitinating and stabilizing Snail1
    Eur J Pharmacol (2023) 947, 175671-175671. PubMed  Europe PubMed DOI
    41. 2022
  41. Alam,S. and Atanassov,B.S.
    New sheriff in town: Cyclic peptide inhibitors of a DUB module
    Cell Chem Biol (2022) 29, 541-543. PubMed  Europe PubMed DOI
  42. Chen,D., Song,D., Ma,Y., Lu,W., Qiu,J. and Wang,Y.
    USP22 promotes proinflammatory responses in Pseudomonas aeruginosainduced keratitis by targeting TRAF6
    Mol Med Rep (2022) 25 PubMed  Europe PubMed DOI
  43. Chen,T., Dong,Y. and Wu,X.
    [Plasma exosomal miR-335-5p serves as a diagnostic indicator and inhibits immune escape in triple-negative breast cancer]
    Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi (2022) 38, 347-356. PubMed  Europe PubMed
  44. Di,Q., Zhao,X., Tang,H., Li,X., Xiao,Y., Wu,H., Wu,Z., Quan,J. and Chen,W.
    USP22 suppresses the NLRP3 inflammasome by degrading NLRP3 via ATG5-dependent autophagy
    Autophagy (2022) , 1-13. PubMed  Europe PubMed DOI
  45. Dietlein,N., Wang,X., Metz,J., Disson,O., Shang,F., Beyersdorffer,C., Rodriguez Correa,E., Lipka,D.B., Begus-Nahrmann,Y., Kosinsky,R.L., Johnsen,S.A., Lecuit,M., Hofer,T. and Rodewald,H.R.
    Usp22 is an intracellular regulator of systemic emergency hematopoiesis
    Sci Immunol (2022) 7, eabq2061-eabq2061. PubMed  Europe PubMed DOI
  46. Guo,J., Zhao,J., Fu,W., Xu,Q. and Huang,D.
    Immune Evasion and Drug Resistance Mediated by USP22 in Cancer: Novel Targets and Mechanisms
    Front Immunol (2022) 13, 918314-918314. PubMed  Europe PubMed DOI  PMC  EPMC  V
  47. Karlowitz,R., Stanifer,M.L., Roedig,J., Andrieux,G., Bojkova,D., Bechtel,M., Smith,S., Kowald,L., Schubert,R., Boerries,M., Cinatl,J., Jr., Boulant,S. and van Wijk,S.J.L.
    USP22 controls type III interferon signaling and SARS-CoV-2 infection through activation of STING
    Cell Death Dis (2022) 13, 684-684. PubMed  Europe PubMed DOI  PMC  EPMC
  48. Ning,Z., Guo,X., Liu,X., Lu,C., Wang,A., Wang,X., Wang,W., Chen,H., Qin,W., Liu,X., Zhou,L., Ma,C., Du,J., Lin,Z., Luo,H., Otkur,W., Qi,H., Chen,D., Xia,T., Liu,J., Tan,G., Xu,G. and Piao,H.L.
    USP22 regulates lipidome accumulation by stabilizing PPARgamma in hepatocellular carcinoma
    Nat Commun (2022) 13, 2187-2187. PubMed  Europe PubMed DOI  PMC  EPMC
  49. Song,S., Wang,Y., Wang,H.Y. and Guo,L.L.
    Role of sevoflurane in myocardial ischemia-reperfusion injury via the ubiquitin-specific protease 22/lysine-specific demethylase 3A axis
    Bioengineered (2022) 13, 13366-13383. PubMed  Europe PubMed DOI  PMC  EPMC
  50. Sun,T., Zhang,K., Li,W., Liu,Y., Pangeni,R.P., Li,A., Arvanitis,L. and Raz,D.J.
    Transcription factor AP2 enhances malignancy of non-small cell lung cancer through upregulation of USP22 gene expression
    Cell Commun Signal (2022) 20, 147-147. PubMed  Europe PubMed DOI  PMC  EPMC  K
  51. Xu,Y., Dalamaga,M. and Liu,J.
    Ubiquitin-specific protease 22 promotes lipogenesis contributing to Hepatocellular Carcinoma pathogenesis
    Metabol Open (2022) 16, 100218-100218. PubMed  Europe PubMed DOI  PMC  EPMC
  52. Zhang,Z., Li,J., Wang,B., Hou,C., Liu,Q., Wang,W., Zhao,Y., Yin,Q., Yang,S., Zhang,H. and Yang,X.
    Ubiquitin-Specific Protease 22 Promotes Neural Stem Cells Stemness Maintenance and Adult Hippocampal Neurogenesis, Contributing to Cognitive Recovery Following Traumatic Brain Injury
    Neuroscience (2022) 496, 219-229. PubMed  Europe PubMed DOI
    53. 2021
  53. Feng,T., Ling,S., Xu,C., Ying,L., Su,D. and Xu,X.
    Ubiquitin-specific peptidase 22 in cancer
    Cancer Lett (2021) 514, 30-37. PubMed  Europe PubMed DOI  V
  54. Jeusset,L.M., Guppy,B.J., Lichtensztejn,Z., McDonald,D. and McManus,K.J.
    Reduced USP22 Expression Impairs Mitotic Removal of H2B Monoubiquitination, Alters Chromatin Compaction and Induces Chromosome Instability That May Promote Oncogenesis
    Cancers (Basel) (2021) 13 PubMed  Europe PubMed DOI  PMC  EPMC
  55. Kosinsky,R.L., Saul,D., Ammer-Herrmenau,C., Faubion,W.A., Neesse,A. and Johnsen,S.A.
    USP22 Suppresses SPARC Expression in Acute Colitis and Inflammation-Associated Colorectal Cancer
    Cancers (Basel) (2021) 13 PubMed  Europe PubMed DOI  PMC  EPMC
  56. Li,M., Xu,Y., Liang,J., Lin,H., Qi,X., Li,F., Han,P., Gao,Y. and Yang,X.
    USP22 deficiency in melanoma mediates resistance to T cells through IFNgamma-JAK1-STAT1 signal axis
    Mol Ther (2021) PubMed  Europe PubMed DOI
  57. Liu,Z., Wang,J., Gao,Y., Guo,Y., Zhu,Y., Sun,Y. and Yang,H.
    USP22 regulates the formation and function of placental vasculature during the development of fetal growth restriction
    Placenta (2021) 111, 19-25. PubMed  Europe PubMed DOI
  58. Prokakis,E., Dyas,A., Grun,R., Fritzsche,S., Bedi,U., Kazerouni,Z.B., Kosinsky,R.L., Johnsen,S.A. and Wegwitz,F.
    USP22 promotes HER2-driven mammary carcinoma aggressiveness by suppressing the unfolded protein response
    Oncogene (2021) 40, 4004-4018. PubMed  Europe PubMed DOI
  59. Ren,D., Sun,Y., Li,D., Wu,H. and Jin,X.
    USP22-mediated deubiquitination of PTEN inhibits pancreatic cancer progression by inducing p21 expression
    Mol Oncol (2021) PubMed  Europe PubMed DOI
  60. Wang,Y., Gao,Y., Zhou,C., Kong,S., Wang,H. and Yang,J.
    Usp22 is expressed in mouse uterus during early pregnancy and involved in endometrial stromal cell decidualization
    Cells Dev (2021) 166, 203681-203681. PubMed  Europe PubMed DOI
  61. Wei,Y., Jiang,Z. and Lu,J.
    USP22 promotes melanoma and BRAF inhibitor resistance via YAP stabilization
    Oncol Lett (2021) 21, 394-394. PubMed  Europe PubMed DOI  PMC  EPMC
  62. Xian,D., Niu,L., Zeng,J. and Wang,L.
    LncRNA KCNQ1OT1 Secreted by Tumor Cell-Derived Exosomes Mediates Immune Escape in Colorectal Cancer by Regulating PD-L1 Ubiquitination via MiR-30a-5p/USP22
    Front Cell Dev Biol (2021) 9, 653808-653808. PubMed  Europe PubMed DOI  PMC  EPMC
  63. Yan,R., Chu,J., Zhou,Y., Shan,W., Hu,Y., Lin,M., Zhao,Y., Sun,R., Wang,Z., Lv,L., Wang,L., Yao,J. and Zhang,N.
    Ubiquitin-specific protease 22 ameliorates chronic alcohol-associated liver disease by regulating BRD4
    Pharmacol Res (2021) 168, 105594-105594. PubMed  Europe PubMed DOI
  64. Zhang,B., Zhang,M., Shen,C., Liu,G., Zhang,F., Hou,J. and Yao,W.
    LncRNA PCBP1-AS1-mediated AR/AR-V7 deubiquitination enhances prostate cancer enzalutamide resistance
    Cell Death Dis (2021) 12, 856-856. PubMed  Europe PubMed DOI  PMC  EPMC
  65. Zhang,L., Wang,J.Y., Li,X., Chen,X.Y. and Wu,W.X.
    [Role of ubiquitin-specific peptidase 22 in multidrug resistance of colorectal cancer and its correlation with multidrug resistance gene P-gp]
    Zhonghua Yi Xue Za Zhi (2021) 101, 3944-3949. PubMed  Europe PubMed DOI
  66. Zhang,W., Liu,T., Li,T. and Zhao,X.
    Hsa_circRNA_102002 facilitates metastasis of papillary thyroid cancer through regulating miR-488-3p/HAS2 axis
    Cancer Gene Ther (2021) 28, 279-293. PubMed  Europe PubMed DOI
  67. Zhou,S., Cai,Y., Liu,X., Jin,L., Wang,X., Ma,W. and Zhang,T.
    Role of H2B mono-ubiquitination in the initiation and progression of cancer
    Bull Cancer (2021) 108, 385-398. PubMed  Europe PubMed DOI  V
    68. 2020

  68. The deubiquitinase USP22 modulates regulatory T-cell function
    Cancer Discov (2020) PubMed  Europe PubMed DOI
  69. Bai,Z., Du,Y., Cong,L. and Cheng,Y.
    The USP22 promotes the growth of cancer cells through the DYRK1A in pancreatic ductal adenocarcinoma
    Gene (2020) 758, 144960-144960. PubMed  Europe PubMed DOI  K
  70. Cai,Z., Zhang,M.X., Tang,Z., Zhang,Q., Ye,J., Xiong,T.C., Zhang,Z.D. and Zhong,B.
    USP22 promotes IRF3 nuclear translocation and antiviral responses by deubiquitinating the importin protein KPNA2
    J Exp Med (2020) 217 PubMed  Europe PubMed DOI
  71. Elumalai,S., Karunakaran,U., Moon,J.S. and Chang Won,K.
    High Glucose-Induced PRDX3 Acetylation Contributes to Glucotoxicity in Pancreatic beta-cells: Prevention by Teneligliptin
    Free Radic Biol Med (2020) PubMed  Europe PubMed DOI  I
  72. Han,B., Sun,Y., Yang,D., Zhang,H., Mo,S., Chen,X., Lu,H., Mao,X. and Hu,J.
    USP22 promotes development of lung adenocarcinoma through ubiquitination and immunosuppression
    Aging (Albany NY) (2020) 12 PubMed  Europe PubMed DOI
  73. He,X., Ma,J., Zhang,M., Cui,J. and Yang,H.
    Long Non-Coding RNA SNHG16 Activates USP22 Expression to Promote Colorectal Cancer Progression by Sponging miR-132-3p
    Onco Targets Ther (2020) 13, 4283-4294. PubMed  Europe PubMed DOI  PMC  EPMC
  74. Jin,D., Wei,W., Song,C., Han,P. and Leng,X.
    Knockdown EZH2 attenuates cerebral ischemia-reperfusion injury via regulating microRNA-30d-3p methylation and USP22
    Brain Res Bull (2020) 169, 25-34. PubMed  Europe PubMed DOI
  75. Kosinsky,R.L., Zerche,M., Saul,D., Wang,X., Wohn,L., Wegwitz,F., Begus-Nahrmann,Y. and Johnsen,S.A.
    USP22 exerts tumor-suppressive functions in colorectal cancer by decreasing mTOR activity
    Cell Death Differ (2020) 27, 1328-1340. PubMed  Europe PubMed DOI
  76. Li,J., Yuan,S., Norgard,R.J., Yan,F., Yamazoe,T., Blanco,A. and Stanger,B.Z.
    Tumor cell-intrinsic USP22 suppresses antitumor immunity in pancreatic cancer
    Cancer Immunol Res (2020) 8, 282-291. PubMed  Europe PubMed DOI
  77. Ling,S., Shan,Q., Zhan,Q., Ye,Q., Liu,P., Xu,S., He,X., Ma,J., Xiang,J., Jiang,G., Wen,X., Feng,Z., Wu,Y., Feng,T., Xu,L., Chen,K., Zhang,X., Wei,R., Zhang,C., Cen,B., Xie,H., Song,P., Liu,J., Zheng,S. and Xu,X.
    USP22 promotes hypoxia-induced hepatocellular carcinoma stemness by a HIF1alpha/USP22 positive feedback loop upon TP53 inactivation
    Gut (2020) 69, 1322-1334. PubMed  Europe PubMed DOI
  78. Ma,S., Sun,L., Wu,W., Wu,J., Sun,Z. and Ren,J.
    USP22 Protects Against Myocardial Ischemia-Reperfusion Injury via the SIRT1-p53/SLC7A11-Dependent Inhibition of Ferroptosis-Induced Cardiomyocyte Death
    Front Physiol (2020) 11, 551318-551318. PubMed  Europe PubMed DOI  PMC  EPMC
  79. Mao,R., Shen,J. and Hu,X.
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  89. Kosinsky,R.L., Helms,M., Zerche,M., Wohn,L., Dyas,A., Prokakis,E., Kazerouni,Z.B., Bedi,U., Wegwitz,F. and Johnsen,S.A.
    USP22-dependent HSP90AB1 expression promotes resistance to HSP90 inhibition in mammary and colorectal cancer
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    Gcn5 and SAGA regulate shelterin protein turnover and telomere maintenance
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