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Literature for peptidase C19.034: ubiquitin-specific peptidase 21

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

(Topics flags: K Knockout, I Inhibitor, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Yang,H., Sun,T., Sun,Z., Wang,H., Liu,D., Wu,D., Qin,T. and Zhou,M.
    Unravelling the role of ubiquitin-specific proteases in breast carcinoma: insights into tumour progression and immune microenvironment modulation
    World J Surg Oncol23, 60-60. PubMed  Europe PubMed DOI  V
  2. Yu,Z., Dong,C., Yang,Y., Zheng,Z. and Ge,X.
    USP21 stabilizes immune checkpoint of CD276 and serves as an immunological and tumor prognostic biomarker
    Biochem Biophys Res Commun745, 151221-151221. PubMed  Europe PubMed DOI
    3. 2024
  3. Ding,J.H., Xiao,Y., Yang,F., Song,X.Q., Xu,Y., Ding,X.H., Ding,R., Shao,Z.M., Di,G.H. and Jiang,Y.Z.
    Guanosine diphosphate-mannose suppresses homologous recombination repair and potentiates antitumor immunity in triple-negative breast cancer
    Sci Transl Med16, eadg7740-eadg7740. PubMed  Europe PubMed DOI
  4. Guo,J., Zhao,Y., Sui,H., Liu,L., Liu,F., Yang,L., Gao,F., Wang,J., Zhu,Y., Li,L., Song,X., Li,P., Tian,Z., Li,P. and Zhao,X.
    USP21-mediated G3BP1 stabilization accelerates proliferation and metastasis of esophageal squamous cell carcinoma via activating Wnt/beta-Catenin signaling
    Oncogenesis13, 23-23. PubMed  Europe PubMed DOI
  5. Lin,J.J. and Lu,Y.C.
    Ubiquitin-specific protease 21 promotes tumorigenicity and stemness of colorectal cancer by deubiquitinating and stabilizing ZEB1
    World J Gastrointest Oncol16, 1006-1018. PubMed  Europe PubMed DOI
  6. Luo,L., Zeng,Z., Li,T., Liu,X., Cui,Y., Tao,Y., Li,Y. and Chen,Y.
    TET2 stabilized by deubiquitinase USP21 ameliorates cigarette smoke-induced apoptosis in airway epithelial cells
    iScience27, 109252-109252. PubMed  Europe PubMed DOI
  7. Ma,Q., Wu,F., Liu,X., Zhao,C., Sun,Y., Li,Y., Zhang,W., Ju,H. and Wang,Y.
    20-hydroxyecdysone suppresses bladder cancer progression via inhibiting USP21: A mechanism associated with deubiquitination and degradation of p65
    Transl Oncol45, 101958-101958. PubMed  Europe PubMed DOI
  8. Shi,Z.Y., Li,C.Y., Chen,R.Y., Shi,J.J., Liu,Y.J., Lu,J.F., Yang,G.J. and Chen,J.
    The emerging role of deubiquitylating enzyme USP21 as a potential therapeutic target in cancer
    Bioorg Chem147, 107400-107400. PubMed  Europe PubMed DOI
  9. Shin,J.H., Kim,M.J., Kim,J.Y., Choi,B., Kang,Y., Kim,S.H., Lee,H.J., Kwon,D., Cho,Y.B., Kim,K.K., Chun,E. and Lee,K.Y.
    USP21-EGFR signaling axis is functionally implicated in metastatic colorectal cancer
    Cell Death Discov10, 492-492. PubMed  Europe PubMed DOI
  10. Sun,X., Yu,J., Cui,X., Tang,Y. and Yu,Y.
    Inhibition of USP21 leads to ovarian carcinoma cell death by suppressing MAPK signaling
    Biotechnol Appl Biochem71, 232-239. PubMed  Europe PubMed DOI
  11. Tak,J., Nguyen,T.K., Lee,K., Kim,S.G. and Ahn,H.C.
    Utilizing machine learning to identify nifuroxazide as an inhibitor of ubiquitin-specific protease 21 in a drug repositioning strategy
    Biomed Pharmacother174, 116459-116459. PubMed  Europe PubMed DOI  I
  12. Wang,L., Cheng,H., Wang,X., Zhu,F., Tian,N., Xu,Z., Yin,H., Liang,M., Yang,X., Liu,X., Shan,H., Fu,R., Cao,B., Li,D., Xiao,L., Lu,L., Dai,S.M., Wang,Q., Lv,L., Zou,H. and Li,B.
    Deubiquitination of aryl hydrocarbon receptor (AhR) by USP21 negatively regulates Th17 cells differentiation
    J Leukoc Biol117, qiae148-qiae148. PubMed  Europe PubMed DOI
  13. Xu,X., Chen,Y., Shao,S., Wang,J., Shan,J., Wang,Y., Wang,Y., Chang,J., Zhou,T., Chen,R., Liu,S., Li,C., Li,C. and Li,X.
    USP21 deubiquitinates and stabilizes HSP90 and ENO1 to promote aerobic glycolysis and proliferation in cholangiocarcinoma
    Int J Biol Sci20, 1492-1508. PubMed  Europe PubMed DOI
  14. Yang,L., Sui,H., Ding,Y., Zhu,Y., Song,X., Zhang,Y., Fan,G., Wang,J., Cui,X., Jiang,Y., Zhao,S., Hong,Y., Mu,N., Tian,Z., Zhao,Y., Li,P. and Zhao,X.
    Disulfiram impairs USP21-mediated MOF-K257 deubiquitination to inhibit esophageal squamous cell carcinoma progression
    Cancer Lett611, 217419-217419. PubMed  Europe PubMed DOI  I
  15. Yao,P., Li,X., Chai,J., Dong,J., Chen,Y., Zhang,T. and Guo,X.
    METTL3-Mediated m6A Methylation of USP21 Contributes to Hepatocellular Carcinoma Progression by Stabilizing H2BFS Through Deubiquitination
    Biochem Genet PubMed  Europe PubMed DOI  K
    16. 2023
  16. Park,S.S. and Baek,K.H.
    Synergistic effect of YOD1 and USP21 on the Hippo signaling pathway
    Cancer Cell Int23, 209-209. PubMed  Europe PubMed DOI
  17. Roy,A., Luharuka,S., Paul,I. and Ray,S.
    Design and development of novel potential inhibitors of the human USP21 enzyme using a pharmacophore-based virtual screening technique
    J Mol Recognit36, e3023-e3023. PubMed  Europe PubMed DOI  I
  18. Wang,Q.D., Shi,T., Xu,Y., Liu,Y. and Zhang,M.J.
    USP21 contributes to the aggressiveness of laryngeal cancer cells by deubiquitinating and stabilizing AURKA
    Kaohsiung J Med Sci39, 354-363. PubMed  Europe PubMed DOI  K
    19. 2022
  19. Qin,Y., Sun,W., Wang,Z., Dong,W., He,L., Zhang,T., Lv,C. and Zhang,H.
    RBM47/SNHG5/FOXO3 axis activates autophagy and inhibits cell proliferation in papillary thyroid carcinoma
    Cell Death Dis13, 270-270. PubMed  Europe PubMed DOI
  20. Wang,Q.D., Liu,L.L., Li,D., Gao,L. and Zhang,M.J.
    Salt-like transcription factor 4 promotes laryngeal cancer progression through transcriptional activation of ubiquitin-specific protease 21 to stabilize Yin Yang 1
    Pathol Int PubMed  Europe PubMed DOI  K
  21. Zhang,Q., Chen,Z., Tang,Q., Wang,Z., Lu,J., You,Y. and Wang,H.
    USP21 promotes self-renewal and tumorigenicity of mesenchymal glioblastoma stem cells by deubiquitinating and stabilizing FOXD1
    Cell Death Dis13, 712-712. PubMed  Europe PubMed DOI
    22. 2021
  22. Gao,W., Li,G., Zhao,S., Wang,H., Huan,C., Zheng,B., Jiang,C. and Zhang,W.
    Deubiquitinating enzyme USP21 inhibits HIV-1 replication by downregulating Tat expression
    J Virol PubMed  Europe PubMed DOI
  23. Hong,Y., Lee,S.O., Oh,C., Kang,K., Ryoo,J., Kim,D. and Ahn,K.
    USP21 Deubiquitinase Regulates AIM2 Inflammasome Activation
    J Immunol207, 1926-1936. PubMed  Europe PubMed DOI
  24. Hou,P., Ma,X., Yang,Z., Zhang,Q., Wu,C.J., Li,J., Tan,L., Yao,W., Yan,L., Zhou,X., Kimmelman,A.C., Lorenzi,P.L., Zhang,J., Jiang,S., Spring,D., Wang,Y.A. and DePinho,R.A.
    USP21 deubiquitinase elevates macropinocytosis to enable oncogenic KRAS bypass in pancreatic cancer
    Genes Dev35, 1327-1332. PubMed  Europe PubMed DOI
  25. Kim,A., Koo,J.H., Jin,X., Kim,W., Park,S.Y., Park,S., Rhee,E.P., Choi,C.S. and Kim,S.G.
    Ablation of USP21 in skeletal muscle promotes oxidative fibre phenotype, inhibiting obesity and type 2 diabetes
    J Cachexia Sarcopenia Muscle PubMed  Europe PubMed DOI
  26. Li,Z., Liu,X., Yu,H., Wang,S., Zhao,S. and Jiang,G.
    USP21 regulates Hippo signaling to promote radioresistance by deubiquitinating FOXM1 in cervical cancer
    Hum Cell PubMed  Europe PubMed DOI  K
  27. Lin,H.C., Kuan,Y., Chu,H.F., Cheng,S.C., Pan,H.C., Chen,W.Y., Sun,C.Y. and Lin,T.H.
    Disulfiram and 6-Thioguanine synergistically inhibit the enzymatic activities of USP2 and USP21
    Int J Biol Macromol176, 490-497. PubMed  Europe PubMed DOI  I
  28. Ma,H., Luo,X., Zhou,P., He,N., Zhou,J., Liu,M. and Xie,W.
    USP21 promotes cell proliferation by maintaining the EZH2 level in diffuse large B-cell lymphoma
    J Clin Lab Anale23693-e23693. PubMed  Europe PubMed DOI
  29. Yang,S., Yan,H., Wu,Y., Shan,B., Zhou,D., Liu,X., Mao,X., Zhou,S., Zhao,Q. and Xia,H.
    Deubiquitination and Stabilization of PD-L1 by USP21
    Am J Transl Res13, 12763-12774. PubMed  Europe PubMed  K
  30. Zhou,P., Song,T., Sun,C., He,N., Cheng,Q., Xiao,X., Ran,J., Liu,M. and Xie,S.
    USP21 upregulation in cholangiocarcinoma promotes cell proliferation and migration in a deubiquitinase-dependent manner
    Asia Pac J Clin Oncol17, 471-477. PubMed  Europe PubMed DOI
    31. 2020
  31. Oshiumi,H.
    Recent Advances and Contradictions in the Study of the Individual Roles of Ubiquitin Ligases That Regulate RIG-I-Like Receptor-Mediated Antiviral Innate Immune Responses
    Front Immunol11, 1296-1296. PubMed  Europe PubMed DOI
  32. Rasaei,R., Sarodaya,N., Kim,K.S., Ramakrishna,S. and Hong,S.H.
    Importance of Deubiquitination in Macrophage-Mediated Viral Response and Inflammation
    Int J Mol Sci21, PubMed  Europe PubMed DOI  V
  33. Sen Nkwe,N., Daou,S., Uriarte,M., Gagnon,J., Iannantuono,N.V., Barbour,H., Yu,H., Masclef,L., Fernandez,E., Zamorano Cuervo,N., Mashtalir,N., Binan,L., Sergeev,M., Belanger,F., Drobetsky,E., Milot,E., Wurtele,H., Costantino,S. and Affar,E.B.
    A potent nuclear export mechanism imposes USP16 cytoplasmic localization during interphase
    J Cell Sci133, jcs239236-jcs239236. PubMed  Europe PubMed DOI
  34. Yun,S.I., Hong,H.K., Yeo,S.Y., Kim,S.H., Cho,Y.B. and Kim,K.K.
    Ubiquitin-specific protease 21 promotes colorectal cancer metastasis by acting as a Fra-1 deubiquitinase
    Cancers (Basel)12, PubMed  Europe PubMed DOI
    35. 2019
  35. Arceci,A., Bonacci,T., Wang,X., Stewart,K., Damrauer,J.S., Hoadley,K.A. and Emanuele,M.J.
    FOXM1 Deubiquitination by USP21 regulates cell cycle progression and paclitaxel sensitivity in basal-like breast cancer
    Cell Rep26, 3076-3086. PubMed  Europe PubMed DOI
  36. Hou,P., Ma,X., Zhang,Q., Wu,C.J., Liao,W., Li,J., Wang,H., Zhao,J., Zhou,X., Guan,C., Ackroyd,J., Jiang,S., Zhang,J., Spring,D.J., Wang,Y.A. and DePinho,R.A.
    USP21 deubiquitinase promotes pancreas cancer cell stemness via Wnt pathway activation
    Genes Dev33, 1361-1366. PubMed  Europe PubMed DOI
  37. Liu,F., Fu,Q., Li,Y., Zhang,K., Tang,M., Jiang,W., Bo,B., Cui,Y. and Kong,L.
    USP21 modulates Goosecoid function through deubiquitination
    Biosci Rep39, PubMed  Europe PubMed DOI
    38. 2018
  38. Li,W., Cui,K., Prochownik,E.V. and Li,Y.
    The deubiquitinase USP21 stabilizes MEK2 to promote tumor growth
    Cell Death Dis9, 482-482. PubMed  Europe PubMed DOI
    39. 2017
  39. Chen,Y., Wang,L., Jin,J., Luan,Y., Chen,C., Li,Y., Chu,H., Wang,X., Liao,G., Yu,Y., Teng,H., Wang,Y., Pan,W., Fang,L., Liao,L., Jiang,Z., Ge,X., Li,B. and Wang,P.
    p38 inhibition provides anti-DNA virus immunity by regulation of USP21 phosphorylation and STING activation
    J Exp Med214, 991-1010. PubMed  Europe PubMed DOI
  40. Chen,Y., Zhou,B. and Chen,D.
    USP21 promotes cell proliferation and metastasis through suppressing EZH2 ubiquitination in bladder carcinoma
    Onco Targets Ther10, 681-689. PubMed  Europe PubMed DOI
  41. Kwon,S.K., Lee,D.H., Kim,S.Y., Park,J.H., Choi,J. and Baek,K.H.
    Ubiquitin-specific protease 21 regulating the K48-linked polyubiquitination of NANOG
    Biochem Biophys Res Commun482, 1443-1448. PubMed  Europe PubMed DOI
  42. Liu,J., Kruswick,A., Dang,H., Tran,A.D., Kwon,S.M., Wang,X.W. and Oberdoerffer,P.
    Ubiquitin-specific protease 21 stabilizes BRCA2 to control DNA repair and tumor growth
    Nat Commun8, 137-137. PubMed  Europe PubMed DOI
  43. Pei,D.
    Deubiquitylating Nanog: novel role of USP21 in embryonic stem cell maintenance
    Signal Transduct Target Ther2, 17014-17014. PubMed  Europe PubMed DOI
    44. 2016
  44. Heride,C., Rigden,D.J., Bertsoulaki,E., Cucchi,D., De Smaele,E., Clague,M.J. and Urbe,S.
    The centrosomal deubiquitylase USP21 regulates Gli1 transcriptional activity and stability
    J Cell Sci129, 4001-4013. PubMed  Europe PubMed DOI
  45. Jin,J., Liu,J., Chen,C., Liu,Z., Jiang,C., Chu,H., Pan,W., Wang,X., Zhang,L., Li,B., Jiang,C., Ge,X., Xie,X. and Wang,P.
    The deubiquitinase USP21 maintains the stemness of mouse embryonic stem cells via stabilization of Nanog
    Nat Commun7, 13594-13594. PubMed  Europe PubMed DOI
  46. Leung,I., Dekel,A., Shifman,J.M. and Sidhu,S.S.
    Saturation scanning of ubiquitin variants reveals a common hot spot for binding to USP2 and USP21
    Proc Natl Acad Sci U S A113, 8705-8710. PubMed  Europe PubMed DOI
  47. Li,Y., Lu,Y., Wang,S., Han,Z., Zhu,F., Ni,Y., Liang,R., Zhang,Y., Leng,Q., Wei,G., Shi,G., Zhu,R., Li,D., Wang,H., Zheng,S.G., Xu,H., Tsun,A. and Li,B.
    USP21 prevents the generation of T-helper-1-like Treg cells
    Nat Commun7, 13559-13559. PubMed  Europe PubMed DOI
  48. Liu,X., Yao,Y., Ding,H., Han,C., Chen,Y., Zhang,Y., Wang,C., Zhang,X., Zhang,Y., Zhai,Y., Wang,P., Wei,W., Zhang,J. and Zhang,L.
    USP21 deubiquitylates Nanog to regulate protein stability and stem cell pluripotency
    Signal Transduct Target Ther1, 16024-16024. PubMed  Europe PubMed DOI
    49. 2015
  49. Pannu,J., Belle,J.I., Forster,M., Duerr,C.U., Shen,S., Kane,L., Harcourt,K., Fritz,J.H., Clare,S. and Nijnik,A.
    Ubiquitin specific protease 21 is dispensable for normal development, hematopoiesis and lymphocyte differentiation
    PLoS ONE10, e0117304-e0117304. PubMed  Europe PubMed DOI  K
    50. 2014
  50. Tao,L., Chen,C., Song,H., Piccioni,M., Shi,G. and Li,B.
    Deubiquitination and stabilization of IL-33 by USP21
    Int J Clin Exp Pathol7, 4930-4937. PubMed  Europe PubMed
    51. 2013
  51. Okuda,H., Ohdan,H., Nakayama,M., Koseki,H., Nakagawa,T. and Ito,T.
    The USP21 short variant (USP21SV) lacking NES, located mostly in the nucleus in vivo, activates transcription by deubiquitylating ubH2A in vitro
    PLoS ONE8, e79813-e79813. PubMed  Europe PubMed DOI
  52. Zhang,J., Chen,C., Hou,X., Gao,Y., Lin,F., Yang,J., Gao,Z., Pan,L., Tao,L., Wen,C., Yao,Z., Tsun,A., Shi,G. and Li,B.
    Identification of the E3 deubiquitinase ubiquitin-specific peptidase 21 (USP21) as a positive regulator of the transcription factor GATA3
    J Biol Chem288, 9373-9382. PubMed  Europe PubMed DOI
    53. 2012
  53. Urbe,S., Liu,H., Hayes,S.D., Heride,C., Rigden,D.J. and Clague,M.J.
    Systematic survey of deubiquitinase localization identifies USP21 as a regulator of centrosome- and microtubule-associated functions
    Mol Biol Cell23, 1095-1103. PubMed  Europe PubMed DOI
    54. 2011
  54. Atanassov,B.S., Koutelou,E. and Dent,S.Y.
    The role of deubiquitinating enzymes in chromatin regulation
    FEBS Lett585, 2016-2023. PubMed  Europe PubMed DOI
  55. Faesen,A.C., Luna-Vargas,M.P., Geurink,P.P., Clerici,M., Merkx,R., van Dijk,W.J., Hameed,D.S., El Oualid,F., Ovaa,H. and Sixma,T.K.
    The differential modulation of USP activity by internal regulatory domains, interactors and eight ubiquitin chain types
    Chem Biol18, 1550-1561. PubMed  Europe PubMed DOI
  56. Ye,Y., Akutsu,M., Reyes-Turcu,F., Enchev,R.I., Wilkinson,K.D. and Komander,D.
    Polyubiquitin binding and cross-reactivity in the USP domain deubiquitinase USP21
    EMBO Rep12, 350-357. PubMed  Europe PubMed DOI
    57. 2010
  57. Koutelou,E., Hirsch,C.L. and Dent,S.Y.
    Multiple faces of the SAGA complex
    Curr Opin Cell Biol22, 374-382. PubMed  Europe PubMed DOI
  58. Xu,G., Tan,X., Wang,H., Sun,W., Shi,Y., Burlingame,S., Gu,X., Cao,G., Zhang,T., Qin,J. and Yang,J.
    Ubiquitin-specific peptidase 21 inhibits tumor necrosis factor alpha-induced nuclear factor kappaB activation via binding to and deubiquitinating receptor-interacting protein 1
    J Biol Chem285, 969-978. PubMed  Europe PubMed DOI
    59. 2008
  59. Nakagawa,T., Kajitani,T., Togo,S., Masuko,N., Ohdan,H., Hishikawa,Y., Koji,T., Matsuyama,T., Ikura,T., Muramatsu,M. and Ito,T.
    Deubiquitylation of histone H2A activates transcriptional initiation via trans-histone cross-talk with H3K4 di- and trimethylation
    Genes Dev22, 37-49. PubMed  Europe PubMed DOI
    60. 2000
  60. [YEAR:12-5-2000]Gong,L., Kamitani,T., Millas,S. and Yeh,E.T.
    Identification of a novel isopeptidase with dual specificity for ubiquitin- and NEDD8-conjugated proteins
    J Biol Chem275, 14212-14216. PubMed  Europe PubMed DOI
    61. 1999
  61. [YEAR:15-12-1999]Valero,R., Marfany,G., Gonzalez-Angulo,O., Gonzalez-Gonzalez,G., Puelles,L. and Gonzalez-Duarte,R.
    USP25, a novel gene encoding a deubiquitinating enzyme, is located in the gene-poor region 21q11.2
    Genomics62, 395-405. PubMed  Europe PubMed DOI

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