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Literature for peptidase C19.026: ubiquitin-specific peptidase 3

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Literature

(Topics flags: R Splicing, I Inhibitor, K Knockout, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2026
  1. Yan,F., Shan,Y., Wang,Y., Fan,X., Wei,P. and Zhao,G.
    USP3 Promotes Glioma Progression by Stabilizing PLK1 through Deubiquitination
    Aging Dis (2026) PubMed  Europe PubMed DOI  K
    2. 2025
  2. Liang,R., Zhang,X., Wu,S., Liu,J., Zhai,Y., Lin,C., Wang,Z., Zhang,Y., Chen,H. and Zhu,R.
    Deubiquitination of DNM1L by USP3 triggers the development and metastasis of gallbladder carcinoma
    Biol Direct (2025) 20, 47-47. PubMed  Europe PubMed DOI  PMC  EPMC
  3. Shi,Y., Cui,J. and Xiaohan,L.
    Vitamin B12 as a novel USP3 deubiquitinase inhibitor suppresses cell proliferation and growth in osteosarcoma
    Biochem Biophys Res Commun (2025) 761, 151640-151640. PubMed  Europe PubMed DOI  I
  4. Xiao,Z., Wang,Y., Pan,D., Liu,X., Gan,J., Huang,L. and Feng,Y.
    USP3 promotes clear cell renal cell carcinoma progression by stabilizing MYC and enhancing glycolysis
    Biochim Biophys Acta Gen Subj (2025) 1869, 130801-130801. PubMed  Europe PubMed DOI
  5. Zhao,W.H., Huang,H., Ding,C., Zhao,Z.X., Jia,C.Y., Wang,Y.J., Hu,Z.X., Wang,G.N., Li,Y.W., Liu,J.H., Liu,H.Y. and Chen,J.
    USP3 stabilizes MIC19 by deubiquitination under hypoxic stress and promotes the progression of non-small cell lung cancer
    Acta Pharmacol Sin (2025) PubMed  Europe PubMed DOI
    6. 2024
  6. Duan,T., Feng,Y., Du,Y., Xing,C., Chu,J., Ou,J., Liu,X., Zhu,M., Qian,C., Yin,B., Wang,H.Y., Cui,J. and Wang,R.F.
    Addendum: USP3 plays a critical role in the induction of innate immune tolerance
    EMBO Rep (2024) 25, 2146-2146. PubMed  Europe PubMed DOI  PMC  EPMC
  7. Li,A., Wang,S., Nie,J., Xiao,S., Xie,X., Zhang,Y., Tong,W., Yao,G., Liu,N., Dan,F., Shu,Z., Liu,J., Liu,Z. and Yang,F.
    USP3 promotes osteosarcoma progression via deubiquitinating EPHA2 and activating the PI3K/AKT signaling pathway
    Cell Death Dis (2024) 15, 235-235. PubMed  Europe PubMed DOI  PMC  EPMC  K
  8. Li,S., Xiong,S., Li,Z., Yang,L., Yang,H., Xiong,J., Pan,W., Guo,J., Xu,S. and Fu,B.
    USP3 promotes DNA damage response and chemotherapy resistance through stabilizing and deubiquitinating SMARCA5 in prostate cancer
    Cell Death Dis (2024) 15, 790-790. PubMed  Europe PubMed DOI  PMC  EPMC
  9. Tao,R., Liu,Z., Zhang,Z. and Zhang,Z.
    USP3 promotes cisplatin resistance in non-small cell lung cancer cells by suppressing ACOT7-regulated ferroptosis
    Anticancer Drugs (2024) 35, 483-491. PubMed  Europe PubMed DOI
  10. Wang,Y., Shi,Y., Niu,K., Yang,R., Lv,Q., Zhang,W., Feng,K. and Zhang,Y.
    Ubiquitin specific peptidase 3: an emerging deubiquitinase that regulates physiology and diseases
    Cell Death Discov (2024) 10, 243-243. PubMed  Europe PubMed DOI  PMC  EPMC  V
  11. Xu,J., Gui,G.S.W., Yang,C., Zhu,S., Chen,Z., Ma,S.L.B., Yang,C., Bu,C.R.L., Zhu,Y. and Xu,W.
    USP3 inhibition is Active Against Chemo-resistant Hepatocellular Carcinoma Anchorage-independent Growth via Suppressing Wnt/beta-catenin
    Curr Mol Med (2024) 24, 667-675. PubMed  Europe PubMed DOI  K
  12. Zhang,H., Liu,W., Wu,Y. and Chen,C.
    USP3: Key deubiquitylation enzyme in human diseases
    Cancer Sci (2024) 115, 2094-2106. PubMed  Europe PubMed DOI  V
    13. 2023
  13. Duan,T., Feng,Y., Du,Y., Xing,C., Chu,J., Ou,J., Liu,X., Zhu,M., Qian,C., Yin,B., Wang,H.Y., Cui,J. and Wang,R.F.
    USP3 plays a critical role in the induction of innate immune tolerance
    EMBO Rep (2023) 24, e57828-e57828. PubMed  Europe PubMed DOI  PMC  EPMC
  14. Karapurkar,J.K., Kim,M.S., Colaco,J.C., Suresh,B., Sarodaya,N., Kim,D.H., Park,C.H., Hong,S.H., Kim,K.S. and Ramakrishna,S.
    CRISPR/Cas9-based genome-wide screening of the deubiquitinase subfamily identifies USP3 as a protein stabilizer of REST blocking neuronal differentiation and promotes neuroblastoma tumorigenesis
    J Exp Clin Cancer Res (2023) 42, 121-121. PubMed  Europe PubMed DOI  PMC  EPMC
    15. 2022
  15. Liang,R.P., Zhang,X.X., Zhao,J., Zhu,R.T., Wang,W.J., Lu,Q.W. and Sun,Y.L.
    Ubiquitin-specific protease 3 facilitates cell proliferation by deubiquitinating pyruvate kinase L/R in gallbladder cancer
    Lab Invest (2022) 102, 1367-1376. PubMed  Europe PubMed DOI  K
  16. Zhao,S., Zheng,B., Wang,L., Cui,W., Jiang,C., Li,Z., Gao,W. and Zhang,W.
    Deubiquitinase ubiquitin-specific protease 3 (USP3) inhibits HIV-1 replication via promoting APOBEC3G (A3G) expression in both enzyme activity-dependent and -independent manners
    Chin Med J (Engl) (2022) 135, 2706-2717. PubMed  Europe PubMed DOI  PMC  EPMC
  17. Zhuang,W., Zhang,L., Zheng,Y., Liu,B., Ma,C., Zhao,W., Liu,S., Liu,F. and Gao,C.
    USP3 deubiquitinates and stabilizes the adapter protein ASC to regulate inflammasome activation
    Cell Mol Immunol (2022) 19, 1141-1152. PubMed  Europe PubMed DOI  PMC  EPMC
    18. 2021
  18. Nagy,Z., Seneviratne,J.A., Kanikevich,M., Chang,W., Mayoh,C., Venkat,P., Du,Y., Jiang,C., Salib,A., Koach,J., Carter,D.R., Mittra,R., Liu,T., Parker,M.W., Cheung,B.B. and Marshall,G.M.
    An ALYREF-MYCN coactivator complex drives neuroblastoma tumorigenesis through effects on USP3 and MYCN stability
    Nat Commun (2021) 12, 1881-1881. PubMed  Europe PubMed DOI  PMC  EPMC
  19. Shi,K., Zhang,J.Z., Yang,L., Li,N.N., Yue,Y., Du,X.H., Zhang,X.Z., Lu,Y.C. and Guo,D.
    Protein deubiquitylase USP3 stabilizes Aurora A to promote proliferation and metastasis of esophageal squamous cell carcinoma
    BMC Cancer (2021) 21, 1196-1196. PubMed  Europe PubMed DOI  PMC  EPMC
  20. Wu,X., Wang,H., Zhu,D., Chai,Y., Wang,J., Dai,W., Xiao,Y., Tang,W., Li,J., Hong,L., Pei,M., Zhang,J., Lin,Z., Wang,J., Li,A. and Liu,S.
    USP3 promotes gastric cancer progression and metastasis by deubiquitination-dependent COL9A3/COL6A5 stabilisation
    Cell Death Dis (2021) 13, 10-10. PubMed  Europe PubMed DOI  PMC  EPMC
  21. Zhang,W., Qi,Y. and Wu,B.
    MicroRNA-146-5p Promotes Pulmonary Artery Endothelial Cell Proliferation under Hypoxic Conditions through Regulating USP3
    Dis Markers (2021) 2021, 3668422-3668422. PubMed  Europe PubMed DOI  PMC  EPMC
  22. Zhou,Q., Wang,W., Wu,J., Qiu,S., Yuan,S., Fu,P.L., Qian,Q.R. and Xu,Y.Z.
    Ubiquitin-specific protease 3 attenuates interleukin-1beta-mediated chondrocyte senescence by deacetylating forkhead box O-3 via sirtuin-3
    Bioengineered (2021) PubMed  Europe PubMed DOI
    23. 2020
  23. Das,S., Chandrasekaran,A.P., Suresh,B., Haq,S., Kang,J.H., Lee,S.J., Kim,J., Kim,J., Lee,S., Kim,H.H., Kim,K.S. and Ramakrishna,S.
    Genome-scale screening of deubiquitinase subfamily identifies USP3 as a stabilizer of Cdc25A regulating cell cycle in cancer
    Cell Death Differ (2020) PubMed  Europe PubMed DOI
  24. Liao,X.H., Wang,Y., Zhong,B. and Zhu,S.Y.
    USP3 promotes proliferation of non-small cell lung cancer through regulating RBM4
    Eur Rev Med Pharmacol Sci (2020) 24, 3143-3151. PubMed  Europe PubMed DOI
  25. Rasaei,R., Sarodaya,N., Kim,K.S., Ramakrishna,S. and Hong,S.H.
    Importance of Deubiquitination in Macrophage-Mediated Viral Response and Inflammation
    Int J Mol Sci (2020) 21 PubMed  Europe PubMed DOI  PMC  EPMC  V
    26. 2019
  26. Chae,Y.C., Jung,H., Kim,J.Y., Lee,D.H. and Seo,S.B.
    Ubiquitin-specific peptidase 3 induces TPA-mediated leukemia cell differentiation via regulating H2AK119ub
    Anim Cells Syst (Seoul) (2019) 23, 311-317. PubMed  Europe PubMed DOI  PMC  EPMC
  27. Fan,L., Chen,Z., Wu,X., Cai,X., Feng,S., Lu,J., Wang,H. and Liu,N.
    Ubiquitin-specific protease 3 promotes glioblastoma cell invasion and epithelial-mesenchymal transition via stabilizing Snail
    Mol Cancer Res (2019) 17, 1975-1984. PubMed  Europe PubMed DOI
  28. Wu,X., Liu,M., Zhu,H., Wang,J., Dai,W., Li,J., Zhu,D., Tang,W., Xiao,Y., Lin,J., Zhang,W., Sun,Y., Zhang,Y., Chen,Y., Li,G., Li,A., Xiang,L., Liu,S. and Wang,J.
    Ubiquitin-specific protease 3 promotes cell migration and invasion by interacting with and deubiquitinating SUZ12 in gastric cancer
    J Exp Clin Cancer Res (2019) 38, 277-277. PubMed  Europe PubMed DOI
  29. Wu,Y., Qin,J., Li,F., Yang,C., Li,Z., Zhou,Z., Zhang,H., Li,Y., Wang,X., Liu,R., Tao,Q., Chen,W. and Chen,C.
    USP3 promotes breast cancer cell proliferation by deubiquitinating KLF5
    J Biol Chem (2019) 294, 17837-17847. PubMed  Europe PubMed DOI
  30. Zhou,Q., Xiao,Z., Zhou,R., Zhou,Y., Fu,P., Li,X., Wu,Y., Wu,H. and Qian,Q.
    Ubiquitin-specific protease 3 targets TRAF6 for deubiquitination and suppresses IL-1beta induced chondrocyte apoptosis
    Biochem Biophys Res Commun (2019) 514, 482-489. PubMed  Europe PubMed DOI
    31. 2018
  31. Cheng,Y.C. and Shieh,S.Y.
    Deubiquitinating enzyme USP3 controls CHK1 chromatin association and activation
    Proc Natl Acad Sci U S A (2018) 115, 5546-5551. PubMed  Europe PubMed DOI  K
    32. 2017
  32. Fu,S., Shao,S., Wang,L., Liu,H., Hou,H., Wang,Y., Wang,H., Huang,X. and Lv,R.
    USP3 stabilizes p53 protein through its deubiquitinase activity
    Biochem Biophys Res Commun (2017) 492, 178-183. PubMed  Europe PubMed DOI
    33. 2014
  33. Cui,J., Song,Y., Li,Y., Zhu,Q., Tan,P., Qin,Y., Wang,H.Y. and Wang,R.F.
    USP3 inhibits type I interferon signaling by deubiquitinating RIG-I-like receptors
    Cell Res (2014) 24, 400-416. PubMed  Europe PubMed DOI
  34. Sharma,N., Zhu,Q., Wani,G., He,J., Wang,Q.E. and Wani,A.A.
    USP3 counteracts RNF168 via deubiquitinating H2A and gammaH2AX at lysine 13 and 15
    Cell Cycle (2014) 13, 106-114. PubMed  Europe PubMed DOI
    35. 2007
  35. Nicassio,F., Corrado,N., Vissers,J.H., Areces,L.B., Bergink,S., Marteijn,J.A., Geverts,B., Houtsmuller,A.B., Vermeulen,W., Di Fiore,P.P. and Citterio,E.
    Human USP3 is a chromatin modifier required for S phase progression and genome stability
    Curr Biol (2007) 17, 1972-1977. PubMed  Europe PubMed DOI
    36. 2006
  36. [YEAR:10-11-2006]Whalen,R., Liu,X. and Boyer,T.D.
    Identification of a short form of ubiquitin-specific protease 3 that is a repressor of rat glutathione S-transferase gene expression
    Biochem J (10-11-2006) 394, 519-526. PubMed  Europe PubMed DOI  PMC  EPMC  R
    37. 1999
  37. [YEAR:17-9-1999]Sloper-Mould,K.E., Eyre,H.J., Wang,X.W., Sutherland,G.R. and Baker,R.T.
    Characterization and chromosomal localization of USP3, a novel human ubiquitin-specific protease
    J Biol Chem (17-9-1999) 274, 26878-26884. PubMed  Europe PubMed DOI

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