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Literature for peptidase C19.026: ubiquitin-specific peptidase 3

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Literature

(Topics flags: R Splicing, I Inhibitor, K Knockout, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2026
  1. Yan,F., Shan,Y., Wang,Y., Fan,X., Wei,P. and Zhao,G.<br>USP3 Promotes Glioma Progression by Stabilizing PLK1 through Deubiquitination<br>Aging Dis (2026) PubMed  Europe PubMed DOI  K
    2. 2025
  2. Liang,R., Zhang,X., Wu,S., Liu,J., Zhai,Y., Lin,C., Wang,Z., Zhang,Y., Chen,H. and Zhu,R.<br>Deubiquitination of DNM1L by USP3 triggers the development and metastasis of gallbladder carcinoma<br>Biol Direct (2025) 20, 47-47. PubMed  Europe PubMed DOI  PMC  EPMC
  3. Shi,Y., Cui,J. and Xiaohan,L.<br>Vitamin B12 as a novel USP3 deubiquitinase inhibitor suppresses cell proliferation and growth in osteosarcoma<br>Biochem Biophys Res Commun (2025) 761, 151640-151640. PubMed  Europe PubMed DOI  I
  4. Xiao,Z., Wang,Y., Pan,D., Liu,X., Gan,J., Huang,L. and Feng,Y.<br>USP3 promotes clear cell renal cell carcinoma progression by stabilizing MYC and enhancing glycolysis<br>Biochim Biophys Acta Gen Subj (2025) 1869, 130801-130801. PubMed  Europe PubMed DOI
  5. Zhao,W.H., Huang,H., Ding,C., Zhao,Z.X., Jia,C.Y., Wang,Y.J., Hu,Z.X., Wang,G.N., Li,Y.W., Liu,J.H., Liu,H.Y. and Chen,J.<br>USP3 stabilizes MIC19 by deubiquitination under hypoxic stress and promotes the progression of non-small cell lung cancer<br>Acta Pharmacol Sin (2025) PubMed  Europe PubMed DOI
    6. 2024
  6. Duan,T., Feng,Y., Du,Y., Xing,C., Chu,J., Ou,J., Liu,X., Zhu,M., Qian,C., Yin,B., Wang,H.Y., Cui,J. and Wang,R.F.<br>Addendum: USP3 plays a critical role in the induction of innate immune tolerance<br>EMBO Rep (2024) 25, 2146-2146. PubMed  Europe PubMed DOI  PMC  EPMC
  7. Li,A., Wang,S., Nie,J., Xiao,S., Xie,X., Zhang,Y., Tong,W., Yao,G., Liu,N., Dan,F., Shu,Z., Liu,J., Liu,Z. and Yang,F.<br>USP3 promotes osteosarcoma progression via deubiquitinating EPHA2 and activating the PI3K/AKT signaling pathway<br>Cell Death Dis (2024) 15, 235-235. PubMed  Europe PubMed DOI  PMC  EPMC  K
  8. Li,S., Xiong,S., Li,Z., Yang,L., Yang,H., Xiong,J., Pan,W., Guo,J., Xu,S. and Fu,B.<br>USP3 promotes DNA damage response and chemotherapy resistance through stabilizing and deubiquitinating SMARCA5 in prostate cancer<br>Cell Death Dis (2024) 15, 790-790. PubMed  Europe PubMed DOI  PMC  EPMC
  9. Tao,R., Liu,Z., Zhang,Z. and Zhang,Z.<br>USP3 promotes cisplatin resistance in non-small cell lung cancer cells by suppressing ACOT7-regulated ferroptosis<br>Anticancer Drugs (2024) 35, 483-491. PubMed  Europe PubMed DOI
  10. Wang,Y., Shi,Y., Niu,K., Yang,R., Lv,Q., Zhang,W., Feng,K. and Zhang,Y.<br>Ubiquitin specific peptidase 3: an emerging deubiquitinase that regulates physiology and diseases<br>Cell Death Discov (2024) 10, 243-243. PubMed  Europe PubMed DOI  PMC  EPMC  V
  11. Xu,J., Gui,G.S.W., Yang,C., Zhu,S., Chen,Z., Ma,S.L.B., Yang,C., Bu,C.R.L., Zhu,Y. and Xu,W.<br>USP3 inhibition is Active Against Chemo-resistant Hepatocellular Carcinoma Anchorage-independent Growth via Suppressing Wnt/beta-catenin<br>Curr Mol Med (2024) 24, 667-675. PubMed  Europe PubMed DOI  K
  12. Zhang,H., Liu,W., Wu,Y. and Chen,C.<br>USP3: Key deubiquitylation enzyme in human diseases<br>Cancer Sci (2024) 115, 2094-2106. PubMed  Europe PubMed DOI  V
    13. 2023
  13. Duan,T., Feng,Y., Du,Y., Xing,C., Chu,J., Ou,J., Liu,X., Zhu,M., Qian,C., Yin,B., Wang,H.Y., Cui,J. and Wang,R.F.<br>USP3 plays a critical role in the induction of innate immune tolerance<br>EMBO Rep (2023) 24, e57828-e57828. PubMed  Europe PubMed DOI  PMC  EPMC
  14. Karapurkar,J.K., Kim,M.S., Colaco,J.C., Suresh,B., Sarodaya,N., Kim,D.H., Park,C.H., Hong,S.H., Kim,K.S. and Ramakrishna,S.<br>CRISPR/Cas9-based genome-wide screening of the deubiquitinase subfamily identifies USP3 as a protein stabilizer of REST blocking neuronal differentiation and promotes neuroblastoma tumorigenesis<br>J Exp Clin Cancer Res (2023) 42, 121-121. PubMed  Europe PubMed DOI  PMC  EPMC
    15. 2022
  15. Liang,R.P., Zhang,X.X., Zhao,J., Zhu,R.T., Wang,W.J., Lu,Q.W. and Sun,Y.L.<br>Ubiquitin-specific protease 3 facilitates cell proliferation by deubiquitinating pyruvate kinase L/R in gallbladder cancer<br>Lab Invest (2022) 102, 1367-1376. PubMed  Europe PubMed DOI  K
  16. Zhao,S., Zheng,B., Wang,L., Cui,W., Jiang,C., Li,Z., Gao,W. and Zhang,W.<br>Deubiquitinase ubiquitin-specific protease 3 (USP3) inhibits HIV-1 replication via promoting APOBEC3G (A3G) expression in both enzyme activity-dependent and -independent manners<br>Chin Med J (Engl) (2022) 135, 2706-2717. PubMed  Europe PubMed DOI  PMC  EPMC
  17. Zhuang,W., Zhang,L., Zheng,Y., Liu,B., Ma,C., Zhao,W., Liu,S., Liu,F. and Gao,C.<br>USP3 deubiquitinates and stabilizes the adapter protein ASC to regulate inflammasome activation<br>Cell Mol Immunol (2022) 19, 1141-1152. PubMed  Europe PubMed DOI  PMC  EPMC
    18. 2021
  18. Nagy,Z., Seneviratne,J.A., Kanikevich,M., Chang,W., Mayoh,C., Venkat,P., Du,Y., Jiang,C., Salib,A., Koach,J., Carter,D.R., Mittra,R., Liu,T., Parker,M.W., Cheung,B.B. and Marshall,G.M.<br>An ALYREF-MYCN coactivator complex drives neuroblastoma tumorigenesis through effects on USP3 and MYCN stability<br>Nat Commun (2021) 12, 1881-1881. PubMed  Europe PubMed DOI  PMC  EPMC
  19. Shi,K., Zhang,J.Z., Yang,L., Li,N.N., Yue,Y., Du,X.H., Zhang,X.Z., Lu,Y.C. and Guo,D.<br>Protein deubiquitylase USP3 stabilizes Aurora A to promote proliferation and metastasis of esophageal squamous cell carcinoma<br>BMC Cancer (2021) 21, 1196-1196. PubMed  Europe PubMed DOI  PMC  EPMC
  20. Wu,X., Wang,H., Zhu,D., Chai,Y., Wang,J., Dai,W., Xiao,Y., Tang,W., Li,J., Hong,L., Pei,M., Zhang,J., Lin,Z., Wang,J., Li,A. and Liu,S.<br>USP3 promotes gastric cancer progression and metastasis by deubiquitination-dependent COL9A3/COL6A5 stabilisation<br>Cell Death Dis (2021) 13, 10-10. PubMed  Europe PubMed DOI  PMC  EPMC
  21. Zhang,W., Qi,Y. and Wu,B.<br>MicroRNA-146-5p Promotes Pulmonary Artery Endothelial Cell Proliferation under Hypoxic Conditions through Regulating USP3<br>Dis Markers (2021) 2021, 3668422-3668422. PubMed  Europe PubMed DOI  PMC  EPMC
  22. Zhou,Q., Wang,W., Wu,J., Qiu,S., Yuan,S., Fu,P.L., Qian,Q.R. and Xu,Y.Z.<br>Ubiquitin-specific protease 3 attenuates interleukin-1beta-mediated chondrocyte senescence by deacetylating forkhead box O-3 via sirtuin-3<br>Bioengineered (2021) PubMed  Europe PubMed DOI
    23. 2020
  23. Das,S., Chandrasekaran,A.P., Suresh,B., Haq,S., Kang,J.H., Lee,S.J., Kim,J., Kim,J., Lee,S., Kim,H.H., Kim,K.S. and Ramakrishna,S.<br>Genome-scale screening of deubiquitinase subfamily identifies USP3 as a stabilizer of Cdc25A regulating cell cycle in cancer<br>Cell Death Differ (2020) PubMed  Europe PubMed DOI
  24. Liao,X.H., Wang,Y., Zhong,B. and Zhu,S.Y.<br>USP3 promotes proliferation of non-small cell lung cancer through regulating RBM4<br>Eur Rev Med Pharmacol Sci (2020) 24, 3143-3151. PubMed  Europe PubMed DOI
  25. Rasaei,R., Sarodaya,N., Kim,K.S., Ramakrishna,S. and Hong,S.H.<br>Importance of Deubiquitination in Macrophage-Mediated Viral Response and Inflammation<br>Int J Mol Sci (2020) 21 PubMed  Europe PubMed DOI  PMC  EPMC  V
    26. 2019
  26. Chae,Y.C., Jung,H., Kim,J.Y., Lee,D.H. and Seo,S.B.<br>Ubiquitin-specific peptidase 3 induces TPA-mediated leukemia cell differentiation via regulating H2AK119ub<br>Anim Cells Syst (Seoul) (2019) 23, 311-317. PubMed  Europe PubMed DOI  PMC  EPMC
  27. Fan,L., Chen,Z., Wu,X., Cai,X., Feng,S., Lu,J., Wang,H. and Liu,N.<br>Ubiquitin-specific protease 3 promotes glioblastoma cell invasion and epithelial-mesenchymal transition via stabilizing Snail<br>Mol Cancer Res (2019) 17, 1975-1984. PubMed  Europe PubMed DOI
  28. Wu,X., Liu,M., Zhu,H., Wang,J., Dai,W., Li,J., Zhu,D., Tang,W., Xiao,Y., Lin,J., Zhang,W., Sun,Y., Zhang,Y., Chen,Y., Li,G., Li,A., Xiang,L., Liu,S. and Wang,J.<br>Ubiquitin-specific protease 3 promotes cell migration and invasion by interacting with and deubiquitinating SUZ12 in gastric cancer<br>J Exp Clin Cancer Res (2019) 38, 277-277. PubMed  Europe PubMed DOI
  29. Wu,Y., Qin,J., Li,F., Yang,C., Li,Z., Zhou,Z., Zhang,H., Li,Y., Wang,X., Liu,R., Tao,Q., Chen,W. and Chen,C.<br>USP3 promotes breast cancer cell proliferation by deubiquitinating KLF5<br>J Biol Chem (2019) 294, 17837-17847. PubMed  Europe PubMed DOI
  30. Zhou,Q., Xiao,Z., Zhou,R., Zhou,Y., Fu,P., Li,X., Wu,Y., Wu,H. and Qian,Q.<br>Ubiquitin-specific protease 3 targets TRAF6 for deubiquitination and suppresses IL-1beta induced chondrocyte apoptosis<br>Biochem Biophys Res Commun (2019) 514, 482-489. PubMed  Europe PubMed DOI
    31. 2018
  31. Cheng,Y.C. and Shieh,S.Y.<br>Deubiquitinating enzyme USP3 controls CHK1 chromatin association and activation<br>Proc Natl Acad Sci U S A (2018) 115, 5546-5551. PubMed  Europe PubMed DOI  K
    32. 2017
  32. Fu,S., Shao,S., Wang,L., Liu,H., Hou,H., Wang,Y., Wang,H., Huang,X. and Lv,R.<br>USP3 stabilizes p53 protein through its deubiquitinase activity<br>Biochem Biophys Res Commun (2017) 492, 178-183. PubMed  Europe PubMed DOI
    33. 2014
  33. Cui,J., Song,Y., Li,Y., Zhu,Q., Tan,P., Qin,Y., Wang,H.Y. and Wang,R.F.<br>USP3 inhibits type I interferon signaling by deubiquitinating RIG-I-like receptors<br>Cell Res (2014) 24, 400-416. PubMed  Europe PubMed DOI
  34. Sharma,N., Zhu,Q., Wani,G., He,J., Wang,Q.E. and Wani,A.A.<br>USP3 counteracts RNF168 via deubiquitinating H2A and gammaH2AX at lysine 13 and 15<br>Cell Cycle (2014) 13, 106-114. PubMed  Europe PubMed DOI
    35. 2007
  35. Nicassio,F., Corrado,N., Vissers,J.H., Areces,L.B., Bergink,S., Marteijn,J.A., Geverts,B., Houtsmuller,A.B., Vermeulen,W., Di Fiore,P.P. and Citterio,E.<br>Human USP3 is a chromatin modifier required for S phase progression and genome stability<br>Curr Biol (2007) 17, 1972-1977. PubMed  Europe PubMed DOI
    36. 2006
  36. [YEAR:10-11-2006]Whalen,R., Liu,X. and Boyer,T.D.<br>Identification of a short form of ubiquitin-specific protease 3 that is a repressor of rat glutathione S-transferase gene expression<br>Biochem J (10-11-2006) 394, 519-526. PubMed  Europe PubMed DOI  PMC  EPMC  R
    37. 1999
  37. [YEAR:17-9-1999]Sloper-Mould,K.E., Eyre,H.J., Wang,X.W., Sutherland,G.R. and Baker,R.T.<br>Characterization and chromosomal localization of USP3, a novel human ubiquitin-specific protease<br>J Biol Chem (17-9-1999) 274, 26878-26884. PubMed  Europe PubMed DOI

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