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Literature for peptidase C19.025: ubiquitin-specific peptidase 20

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Literature Substrates Inhibitors

(Topics flags: K Knockout, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2026
  1. Bai,Y., Liu,Z., Zhai,X., Zhang,D., Liu,S., Xia,Q., Chen,L., Shi,Y., Liao,Y., Liu,Y., Zhang,Z., Xu,S., Gong,J., Zhao,C., Wang,M., Shi,X., Zhu,F. and Qin,R.
    USP20-RAB8A signaling axis restricts pancreatic cancer progression by disrupting GLUT1 vesicular trafficking and inhibiting glucose uptake
    Cancer Lett (2026) 642, 218299-218299. PubMed  Europe PubMed DOI  K
    2. 2025
  2. Dai,S., Zhang,Y., Huang,Z., Chen,Y., Yang,Z., Zheng,R., Ye,K., Zhong,L., Zheng,X., Cai,X. and Huang,W.
    Cardiomyocyte USP20 alleviates septic cardiomyopathy by deubiquitinating and inhibiting NLRP3 activity
    Clin Transl Med (2025) 15, e70494-e70494. PubMed  Europe PubMed DOI  PMC  EPMC
  3. Ding,Y., Zhang,T., Ma,H.B., Han,J., Zhu,W., Zhao,X., Lu,X.Y., Zhou,B. and Shi,X.J.
    Chronic Exposure to Environmental Concentrations of Tetrabromobisphenol A Disrupts Insulin and Lipid Homeostasis in Diet-Induced Obese Mice
    Environ Sci Technol (2025) PubMed  Europe PubMed DOI
  4. Guo,L., Zhang,B., Cui,X., Wang,X., Xiao,J., Miao,S., Song,K. and Sun,J.
    USP20 competitively binds to STUB1 to enhance CTSL expression and promote epithelial-mesenchymal transition in head and neck squamous cell carcinoma
    Clin Transl Med (2025) 15, e70520-e70520. PubMed  Europe PubMed DOI  PMC  EPMC
  5. Wang,Y., Wang,X., Fang,J., Chen,X., Xu,T., Zhuang,T., Peng,S., Bao,W., Wu,W., Lu,Y., Wang,H., Tomlinson,B., Chan,P., Zhuang,S., Zhang,Q., Zhang,L., Liu,Z., Pi,J., Zhang,Y. and Liu,J.
    Cardiomyocyte Foxp1-Specific Deletion Promotes Post-injury Heart Regeneration via Targeting Usp20-HIF1a-Hand1 Signaling Pathway
    Adv Sci (Weinh) (2025) , e2412124-e2412124. PubMed  Europe PubMed DOI
  6. Xu,L., Zhang,Z., Yu,J., Ji,T., Cheng,J., Fei,X., Chu,X., Tao,Y., Xu,Y., Yang,P., Liu,W., Li,G., Zhang,Y., Li,Y., Zhang,F., Yang,Y., Zhou,B., Wu,Y., Wei,Z., Chen,Y., Wang,J., Wu,D., Li,X., Yang,Y., Qian,G., Yin,H., Wu,S., Zhang,S., Liu,D., Fan,J.J., Shi,L., Wang,X., Hu,S., Lu,J. and Pan,J.
    USP20 as a super-enhancer-regulated gene drives T-ALL progression via HIF1A deubiquitination
    Acta Pharm Sin B (2025) 15, 4751-4771. PubMed  Europe PubMed DOI  PMC  EPMC  K
  7. Zhong,L., Dai,S., Yu,F., Shi,G.P., Gong,Q., Zhang,Y., Duan,J., Lou,Z., Tang,Z., Gong,F., Chen,D., Hou,L., Hu,X., Chen,J., Wang,J. and Yin,D.
    Cardiomyocyte-Enriched USP20 Ameliorates Pathological Cardiac Hypertrophy by Targeting STAT3 Deubiquitination
    Adv Sci (Weinh) (2025) , e2416478-e2416478. PubMed  Europe PubMed DOI
    8. 2024
  8. Jean-Charles,P.Y., Roy,B., Yu,S.M., Pironti,G., Nagi,K., Mao,L., Kaur,S., Abraham,D.M., Maudsley,S., Rockman,H.A. and Shenoy,S.K.
    Usp20 deletion promotes eccentric cardiac remodeling in response to pressure overload and increases mortality
    Am J Physiol Heart Circ Physiol (2024) 327, H1257-H1271. PubMed  Europe PubMed DOI
  9. Liu,Y., Li,D., Zhang,X., Xia,S., Qu,Y., Ling,X., Li,Y., Kong,X., Zhang,L., Cui,C.P. and Li,D.
    A protein sequence-based deep transfer learning framework for identifying human proteome-wide deubiquitinase-substrate interactions
    Nat Commun (2024) 15, 4519-4519. PubMed  Europe PubMed DOI  PMC  EPMC
  10. Xue,Y., Xue,C. and Song,W.
    Emerging roles of deubiquitinating enzymes in actin cytoskeleton and tumor metastasis
    Cell Oncol (Dordr) (2024) PubMed  Europe PubMed DOI  V
  11. Zhang,F., Liu,C., Chen,Z. and Zhao,C.
    A novel PDIA3/FTO/USP20 positive feedback regulatory loop induces osteogenic differentiation of preosteoblast in osteoporosis
    Cell Biol Int (2024) 48, 541-550. PubMed  Europe PubMed DOI
  12. Zhang,M., Wang,Z., Zhao,Q., Yang,Q., Bai,J., Yang,C., Zhang,Z.R. and Liu,Y.
    USP20 deubiquitinates and stabilizes the reticulophagy receptor RETREG1/FAM134B to drive reticulophagy
    Autophagy (2024) , 1-18. PubMed  Europe PubMed DOI
    13. 2023
  13. Ghoreshi,Z.A., Molaei,H.R. and Arefinia,N.
    The Role of DNA Viruses in Human Cancer
    Cancer Inform (2023) 22, 11769351231154186-11769351231154186. PubMed  Europe PubMed DOI  PMC  EPMC  V
  14. Jin,R., Luo,Z., Jun,L., Tao,Q., Wang,P., Cai,X., Jiang,L., Zeng,C. and Chen,Y.
    USP20 is a predictor of poor prognosis in colorectal cancer and associated with lymph node metastasis, immune infiltration and chemotherapy resistance
    Front Oncol (2023) 13, 1023292-1023292. PubMed  Europe PubMed DOI  PMC  EPMC
  15. Zhang,L., Wu,J.H., Jean-Charles,P.Y., Murali,P., Zhang,W., Jazic,A., Kaur,S., Nepliouev,I., Stiber,J.A., Snow,K., Freedman,N.J. and Shenoy,S.K.
    Phosphorylation of USP20 on Ser334 by IRAK1 promotes IL-1beta-evoked signaling in vascular smooth muscle cells and vascular inflammation
    J Biol Chem (2023) 299, 104911-104911. PubMed  Europe PubMed DOI  PMC  EPMC
    16. 2022
  16. Feng,J., Liu,P., Li,X., Zhang,D., Lin,H., Hou,Z., Guo,C., Niu,Y., Dai,B., Wang,O., Qi,M., Wang,H. and Zhou,H.
    The deubiquitinating enzyme USP20 regulates the stability of the MCL1 protein
    Biochem Biophys Res Commun (2022) 593, 122-128. PubMed  Europe PubMed DOI
  17. Guan,Y., Jiang,S.R., Liu,J.G., Shi,J.R. and Liu,Z.B.
    USP20 regulates the stability of EMT transcription factor SOX4 and influences colorectal cancer metastasis
    Pathol Res Pract (2022) 233, 153879-153879. PubMed  Europe PubMed DOI
  18. Li,Q., Ye,C., Tian,T., Jiang,Q., Zhao,P., Wang,X., Liu,F., Shan,J. and Ruan,J.
    The emerging role of ubiquitin-specific protease 20 in tumorigenesis and cancer therapeutics
    Cell Death Dis (2022) 13, 434-434. PubMed  Europe PubMed DOI  PMC  EPMC  V
  19. Pan,R., Xie,Y., Fang,W., Liu,Y. and Zhang,Y.
    USP20 mitigates ischemic stroke in mice by suppressing neuroinflammation and neuron death via regulating PTEN signal
    Int Immunopharmacol (2022) 103, 107840-107840. PubMed  Europe PubMed DOI
  20. Qin,B., Zhou,L., Wang,F. and Wang,Y.
    Ubiquitin-specific protease 20 in human disease: Emerging role and therapeutic implications
    Biochem Pharmacol (2022) 206, 115352-115352. PubMed  Europe PubMed DOI
    21. 2021
  21. Hu,S., Chen,X., Zhu,M., Hu,H., Zhou,C., Shi,L. and Zhang,N.
    Expression, purification and characterization of the second DUSP domain of deubiquitinase USP20/VDU2
    Protein Expr Purif (2021) 181, 105836-105836. PubMed  Europe PubMed DOI
  22. Lu,R., Wu,G., Chen,M., Ji,D., Liu,Y., Zhou,G.G. and Fu,W.
    USP18 and USP20 restrict oHSV-1 replication in resistant human oral squamous carcinoma cell line SCC9 and affect the viability of SCC9 cells
    Mol Ther Oncolytics (2021) 23, 477-487. PubMed  Europe PubMed DOI  PMC  EPMC  K
    23. 2020
  23. Ha,J., Kim,M., Seo,D., Park,J.S., Lee,J., Lee,J. and Park,S.H.
    The deubiquitinating enzyme USP20 regulates the TNFalpha-induced NF-kappaB signaling pathway through stabilization of p62
    Int J Mol Sci (2020) 21 PubMed  Europe PubMed DOI
  24. Lu,X.Y., Shi,X.J., Hu,A., Wang,J.Q., Ding,Y., Jiang,W., Sun,M., Zhao,X., Luo,J., Qi,W. and Song,B.L.
    Feeding induces cholesterol biosynthesis via the mTORC1-USP20-HMGCR axis
    Nature (2020) PubMed  Europe PubMed DOI
    25. 2019
  25. Yang,Y., Ding,Y., Zhou,C., Wen,Y. and Zhang,N.
    Structural and functional studies of USP20 ZnF-UBP domain by NMR
    Protein Sci (2019) 28, 1606-1619. PubMed  Europe PubMed DOI
  26. Zhang,M.X., Cai,Z., Zhang,M., Wang,X.M., Wang,Y., Zhao,F., Zhou,J., Luo,M.H., Zhu,Q., Xu,Z., Zeng,W.B., Zhong,B. and Lin,D.
    USP20 Promotes cellular antiviral responses via deconjugating K48-linked ubiquitination of MITA
    J Immunol (2019) 202, 2397-2406. PubMed  Europe PubMed DOI
    27. 2018
  27. Kim,J.H., Seo,D., Kim,S.J., Choi,D.W., Park,J.S., Ha,J., Choi,J., Lee,J.H., Jung,S.M., Seo,K.W., Lee,E.W., Lee,Y.S., Cheong,H., Choi,C.Y. and Park,S.H.
    The deubiquitinating enzyme USP20 stabilizes ULK1 and promotes autophagy initiation
    EMBO Rep (2018) 19, e44378-e44378. PubMed  Europe PubMed DOI
  28. Wu,C., Luo,K., Zhao,F., Yin,P., Song,Y., Deng,M., Huang,J., Chen,Y., Li,L., Lee,S., Kim,J., Zhou,Q., Tu,X., Nowsheen,S., Luo,Q., Gao,X., Lou,Z., Liu,Z. and Yuan,J.
    USP20 positively regulates tumorigenesis and chemoresistance through beta-catenin stabilization
    Cell Death Differ (2018) 25, 1855-1869. PubMed  Europe PubMed DOI
    29. 2017
  29. Mathien,S., Deleris,P., Soulez,M., Voisin,L. and Meloche,S.
    Deubiquitinating enzyme USP20 regulates extracellular signal-regulated kinase 3 stability and biological activity
    Mol Cell Biol (2017) 37, e00432-16.-e00432-16. PubMed  Europe PubMed DOI
  30. Yang,Y., Wen,Y. and Zhang,N.
    (1)H (13)C and (15)N backbone and side-chain resonance assignments of the ZnF-UBP domain of USP20/VDU2
    Biomol NMR Assign (2017) 11, 91-93. PubMed  Europe PubMed DOI
    31. 2016
  31. Jean-Charles,P.Y., Zhang,L., Wu,J.H., Han,S.O., Brian,L., Freedman,N.J. and Shenoy,S.K.
    Ubiquitin-specific protease 20 regulates the reciprocal functions of beta-arrestin2 in toll-like receptor 4-promoted nuclear factor kappaB (NFkappaB) activation
    J Biol Chem (2016) 291, 7450-7464. PubMed  Europe PubMed DOI
    32. 2015
  32. Kim,S.R., Kim,J.O., Lim,K.H., Yun,J.H., Han,I. and Baek,K.H.
    Regulation of pyruvate kinase isozyme M2 is mediated by the ubiquitin-specific protease 20
    Int J Oncol (2015) 46, 2116-2124. PubMed  Europe PubMed DOI
  33. Kommaddi,R.P., Jean-Charles,P.Y. and Shenoy,S.K.
    Phosphorylation of the deubiquitinase USP20 by protein kinase A regulates post-endocytic trafficking of beta2 adrenergic receptors to autophagosomes during physiological stress
    J Biol Chem (2015) 290, 8888-8903. PubMed  Europe PubMed DOI
    34. 2014
  34. Shanmugam,I., Abbas,M., Ayoub,F., Mirabal,S., Bsaili,M., Caulder,E.K., Weinstock,D.M., Tomkinson,A.E., Hromas,R. and Shaheen,M.
    Ubiquitin-specific peptidase 20 regulates Rad17 stability, checkpoint kinase 1 phosphorylation and DNA repair by homologous recombination
    J Biol Chem (2014) 289, 22739-22748. PubMed  Europe PubMed DOI
  35. Yuan,J., Luo,K., Deng,M., Li,Y., Yin,P., Gao,B., Fang,Y., Wu,P., Liu,T. and Lou,Z.
    HERC2-USP20 axis regulates DNA damage checkpoint through Claspin
    Nucleic Acids Res (2014) 42, 13110-13121. PubMed  Europe PubMed DOI
  36. Zhu,M., Zhao,H., Liao,J. and Xu,X.
    HERC2/USP20 coordinates CHK1 activation by modulating CLASPIN stability
    Nucleic Acids Res (2014) 42, 13074-13081. PubMed  Europe PubMed DOI
    37. 2013
  37. Park,J.J., Yun,J.H. and Baek,K.H.
    Polyclonal and monoclonal antibodies specific for ubiquitin-specific protease 20
    Monoclon Antib Immunodiagn Immunother (2013) 32, 193-199. PubMed  Europe PubMed DOI
    38. 2011
  38. Yasunaga,J., Lin,F.C., Lu,X. and Jeang,K.T.
    Ubiquitin-specific peptidase 20 targets TRAF6 and human T cell leukemia virus type 1 Tax to negatively regulate NF-kappaB signaling
    J Virol (2011) 85, 6212-6219. PubMed  Europe PubMed DOI
    39. 2009
  39. Berthouze,M., Venkataramanan,V., Li,Y. and Shenoy,S.K.
    The deubiquitinases USP33 and USP20 coordinate beta2 adrenergic receptor recycling and resensitization
    EMBO J (2009) 28, 1684-1696. PubMed  Europe PubMed DOI  PMC  EPMC
    40. 2005
  40. Li,Z., Wang,D., Messing,E.M. and Wu,G.
    VHL protein-interacting deubiquitinating enzyme 2 deubiquitinates and stabilizes HIF-1alpha
    EMBO Rep (2005) 6, 373-378. PubMed  Europe PubMed DOI  PMC  EPMC
    41. 2003
  41. Curcio-Morelli,C., Zavacki,A.M., Christofollete,M., Gereben,B., de Freitas,B.C., Harney,J.W., Li,Z., Wu,G. and Bianco,A.C.
    Deubiquitination of type 2 iodothyronine deiodinase by von Hippel-Lindau protein-interacting deubiquitinating enzymes regulates thyroid hormone activation
    J Clin Invest (2003) 112, 189-196. PubMed  Europe PubMed DOI  PMC  EPMC
    42. 2002
  42. [YEAR:14-6-2002]Li,Z., Wang,D., Na,X., Schoen,S.R., Messing,E.M. and Wu,G.
    Identification of a deubiquitinating enzyme subfamily as substrates of the von Hippel-Lindau tumor suppressor
    Biochem Biophys Res Commun (14-6-2002) 294, 700-709. PubMed  Europe PubMed DOI

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