Literature for peptidase C19.024: ubiquitin-specific peptidase 19

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Literature Substrates

(Topics flags: P Specificity, I Inhibitor, K Knockout, L Localization, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

2025

Fang,X., Fan,Y., Liu,N. and Huang,S. USP19 restores mitochondrial function in neurons by deubiquitinating FUS to alleviate trigeminal neuralgia Exp Brain Res (2025) 244, 13-13. PubMed Europe PubMed DOI K
Picard,F., Nonaka,T., Belotti,E., Osseni,A., Errazuriz-Cerda,E., Jost-Mousseau,C., Bernard,E., Conjard-Duplany,A., Bohl,D., Hasegawa,M., Raoul,C., Galli,T., Schaeffer,L. and Leblanc,P. Enhanced secretion of the amyotrophic lateral sclerosis ALS-associated misfolded TDP-43 mediated by the ER-ubiquitin specific peptidase USP19 Cell Mol Life Sci (2025) 82, 76-76. PubMed Europe PubMed DOI PMC EPMC
Shao,S., Li,W., Hong,Y., Zeng,R., Zhu,L., Yi,L., Li,Y., Wang,Y., Huang,H., Jiang,X. and Jin,X. ZDHHC2-Dependent Palmitoylation Dictates Ferroptosis and Castration Sensitivity in Prostate Cancer via Controlling ACSL4 Degradation and Lipid Peroxidation Adv Sci (Weinh) (2025) , e14077-e14077. PubMed Europe PubMed DOI
Shi,F., Li,G.J., Liu,Y., Zhou,H.M., Zhang,Y., Wei,S.Y., Zan,B.J., Gao,M., Chen,F.S., Li,B.X., Wang,B.Q., Dong,M.Y., Du,R.L. and Zhang,X.D. USP19 deficiency enhances T-cell-mediated antitumor immunity by promoting PD-L1 degradation in colorectal cancer Pharmacol Res (2025) , 107668-107668. PubMed Europe PubMed DOI
Zhang,D., Zhang,X., Chang,S., Zhao,Y. and Zhang,L. E2F1 activates USP19 to affect the stability of c-Myc to facilitate the progression of hepatocellular carcinoma Mutat Res (2025) 830, 111902-111902. PubMed Europe PubMed DOI K

2024

Bonelli,S., Lo Pinto,M., Ye,Y., Mueller,S.A., Lichtenthaler,S.F. and Scilabra,S.D. Proteomic characterization of ubiquitin carboxyl-terminal hydrolase 19 deficient cells reveals a role for USP19 in secretion of lysosomal proteins Mol Cell Proteomics (2024) , 100854-100854. PubMed Europe PubMed DOI
Ho,H.H. and Wing,S.S. alpha-Synuclein ubiquitination - functions in proteostasis and development of Lewy bodies Front Mol Neurosci (2024) 17, 1498459-1498459. PubMed Europe PubMed DOI PMC EPMC V
Li,Y., Liu,X., Li,Y., Wang,J., Zhang,M., Xue,W. and Zhang,M. USP19 exerts a tumor-promoting role in diffuse large B cell lymphoma through stabilizing PARK7 FEBS J (2024) 291, 4757-4774. PubMed Europe PubMed DOI K
Liu,J., Wang,K., Zhu,Q., Zhang,Y., Chen,Y., Lou,Z. and Yuan,J. USP19 regulates DNA methylation damage repair and confers temozolomide resistance through MGMT stabilization CNS Neurosci Ther (2024) 30, e14711-e14711. PubMed Europe PubMed DOI PMC EPMC
Olie,C.S., O'Brien,D.P., Jones,H.B.L., Liang,Z., Damianou,A., Sur-Erdem,I., Pinto-Fernandez,A., Raz,V. and Kessler,B.M. Deubiquitinases in muscle physiology and disorders Biochem Soc Trans (2024) 52, 1085-1098. PubMed Europe PubMed DOI V
Tyagi,A., Karapurkar,J.K., Colaco,J.C., Sarodaya,N., Antao,A.M., Kaushal,K., Haq,S., Chandrasekaran,A.P., Das,S., Singh,V., Hong,S.H., Suresh,B., Kim,K.S. and Ramakrishna,S. USP19 Negatively Regulates p53 and Promotes Cervical Cancer Progression Mol Biotechnol (2024) 66, 2032-2045. PubMed Europe PubMed DOI
Wang,G., Dai,S., Chen,J., Zhang,K., Huang,C., Zhang,J., Xie,K., Lin,F., Wang,H., Gao,Y., Yin,L., Jiang,K., Miao,Y. and Lu,Z. USP19 potentiates autophagic cell death via inhibiting mTOR pathway through deubiquitinating NEK9 in pancreatic cancer Cell Death Differ (2024) PubMed Europe PubMed DOI K
Weerawardhana,A., Herath,T.U.B., Gayan Chathuranga,W.A., Kim,T.H., Ekanayaka,P., Chathuranga,K., Kang,H.C., Jung,J.U. and Lee,J.S. SIAH1 modulates antiviral immune responses by targeting deubiquitinase USP19 J Med Virol (2024) 96, e29523-e29523. PubMed Europe PubMed DOI
Xu,J., Chen,S., Liu,D., Zhang,Q., Luo,T., Zhu,J., Zhou,L., Lin,Y., Pan,H., Chen,Y., Zhao,Q., Wang,T., Andrea,S., Nashan,B., Stefan,T.G., Cai,C., Cui,J., He,X. and Guo,Z. Suppression of Hepatocyte Ferroptosis via USP19-Mediated Deubiquitination of SLC7A11 in Ischemia-Free Liver Transplantation Adv Sci (Weinh) (2024) , e2406200-e2406200. PubMed Europe PubMed DOI
Yan,X.H., Zhu,Y.N. and Zhu,Y.T. USP19 Stabilizes TAK1 to Regulate High Glucose/Free Fatty Acid-induced Dysfunction in HK-2 Cells Curr Med Sci (2024) 44, 707-717. PubMed Europe PubMed DOI K
Yu,W., Zhuang,S., Zhan,M., Chen,Y., Zhang,J., Chen,L., Tu,C., Zheng,L. and Chen,S. Deubiquitinating Enzyme USP19 Regulates Ferroptosis and Mitochondrial Damage in SH-SY5Y Cells by Targeting the NOX4 Protein J Alzheimers Dis (2024) 100, 799-808. PubMed Europe PubMed DOI K

2023

Schorova,L., Bedard,N., Khayachi,A., Ho,H.H., Bolivar-Pedroso,J., Huynh,J., Piccirelli,M., Wang,Y., Plourde,M., Luo,W., Del Cid-Pellitero,E., Shlaifer,I., Castellanos-Montiel,M.J., Yu,Z., Valenzuela,D.V.C., Lacalle-Aurioles,M., Kriz,A., Ye,Y., Durcan,T.M. and Wing,S.S. USP19 deubiquitinase inactivation regulates alpha-synuclein ubiquitination and inhibits accumulation of Lewy body-like aggregates in mice NPJ Parkinsons Dis (2023) 9, 157-157. PubMed Europe PubMed DOI PMC EPMC
Tian,Z., Xu,C., He,W., Lin,Z., Zhang,W., Tao,K., Ding,R., Zhang,X. and Dou,K. The deubiquitinating enzyme USP19 facilitates hepatocellular carcinoma progression through stabilizing YAP Cancer Lett (2023) 577, 216439-216439. PubMed Europe PubMed DOI K
You,Y., Wang,H., Wang,Q., Yu,Z., Zhao,Z., Zhuang,L., Zeng,S., Zheng,J. and Wen,W. Silencing USP19 alleviates cigarette smoke extract-induced mitochondrial dysfunction in BEAS-2B cells by targeting FUNDC1 Open Med (Wars) (2023) 18, 20230798-20230798. PubMed Europe PubMed DOI PMC EPMC K
Zhang,X., Chen,X., Qian,F., Zhu,Y., He,G., Yang,J., Wu,X., Zhang,H., Yu,X. and Liu,X. Deubiquitinase USP19 modulates apoptotic calcium release and endoplasmic reticulum stress by deubiquitinating BAG6 in triple negative breast cancer Clin Transl Med (2023) 13, e1398-e1398. PubMed Europe PubMed DOI PMC EPMC

2022

Dhingra,R., Rabinovich-Nikitin,I., Rothman,S., Guberman,M., Gang,H., Margulets,V., Jassal,D.S., Alagarsamy,K.N., Dhingra,S., Valenzuela Ripoll,C., Billia,F., Diwan,A., Javaheri,A. and Kirshenbaum,L.A. Proteasomal Degradation of TRAF2 Mediates Mitochondrial Dysfunction in Doxorubicin-Cardiomyopathy Circulation (2022) 146, 934-954. PubMed Europe PubMed DOI
Hu,S., Xiang,Y., Qiu,L., Wang,M. and Zhang,Y. Activation of the membrane-bound Nrf1 transcription factor by USP19, a ubiquitin-specific protease C-terminally anchored in the endoplasmic reticulum Biochim Biophys Acta Mol Cell Res (2022) 1869, 119299-119299. PubMed Europe PubMed DOI
Rossi,F.A. and Rossi,M. Emerging Role of Ubiquitin-Specific Protease 19 in Oncogenesis and Cancer Development Front Cell Dev Biol (2022) 10, 889166-889166. PubMed Europe PubMed DOI PMC EPMC V
Sarodaya,N., Tyagi,A., Kim,H.J., Colaco,J.C., Kang,J.S., Kim,W.J., Kim,K.S. and Ramakrishna,S. Deubiquitinase USP19 enhances phenylalanine hydroxylase protein stability and its enzymatic activity Cell Biol Toxicol (2022) PubMed Europe PubMed DOI

2021

Chai,P., Cheng,Y., Hou,C., Yin,L., Zhang,D., Hu,Y., Chen,Q., Zheng,P., Teng,J. and Chen,J. USP19 promotes hypoxia-induced mitochondrial division via FUNDC1 at ER-mitochondria contact sites J Cell Biol (2021) 220 PubMed Europe PubMed DOI PMC EPMC
Li,T., Tan,Y., Ouyang,S., He,J. and Liu,L. Resveratrol protects against myocardial ischemia-reperfusion injury via attenuating ferroptosis Gene (2021) 808, 145968-145968. PubMed Europe PubMed DOI I
Rossi,F.A., Enrique Steinberg,J.H., Calvo Roitberg,E.H., Joshi,M.U., Pandey,A., Abba,M.C., Dufrusine,B., Buglioni,S., De Laurenzi,V., Sala,G., Lattanzio,R., Espinosa,J.M. and Rossi,M. USP19 modulates cancer cell migration and invasion and acts as a novel prognostic marker in patients with early breast cancer Oncogenesis (2021) 10, 28-28. PubMed Europe PubMed DOI PMC EPMC
Zhao,X., Di,Q., Yu,J., Quan,J., Xiao,Y., Zhu,H., Li,H., Ling,J. and Chen,W. USP19 (ubiquitin specific peptidase 19) promotes TBK1 (TANK-binding kinase 1) degradation via chaperone-mediated autophagy Autophagy (2021) , 1-18. PubMed Europe PubMed DOI
Zhu,Y., Gu,L., Lin,X., Zhou,X., Lu,B., Liu,C., Lei,C., Zhou,F., Zhao,Q., Prochownik,E.V. and Li,Y. USP19 exacerbates lipogenesis and colorectal carcinogenesis by stabilizing ME1 Cell Rep (2021) 37, 110174-110174. PubMed Europe PubMed DOI

2020

Boscaro,C., Carotti,M., Albiero,M., Trenti,A., Fadini,G.P., Trevisi,L., Sandona,D., Cignarella,A. and Bolego,C. Non-genomic mechanisms in the estrogen regulation of glycolytic protein levels in endothelial cells FASEB J (2020) PubMed Europe PubMed DOI K I
Dong,Z., Guo,S., Wang,Y., Zhang,J., Luo,H., Zheng,G., Yang,D., Zhang,T., Yan,L., Song,L., Liu,K., Sun,Z., Meng,X., Zheng,Z., Zhang,J. and Zhao,Y. USP19 Enhances MMP2/MMP9-Mediated Tumorigenesis in Gastric Cancer Onco Targets Ther (2020) 13, 8495-8510. PubMed Europe PubMed DOI PMC EPMC L
Liu,T., Wang,L., Liang,P., Wang,X., Liu,Y., Cai,J., She,Y., Wang,D., Wang,Z., Guo,Z., Bates,S., Xia,X., Huang,J. and Cui,J. USP19 suppresses inflammation and promotes M2-like macrophage polarization by manipulating NLRP3 function via autophagy Cell Mol Immunol (2020) PubMed Europe PubMed DOI

2019

Coyne,E.S., Bedard,N., Gong,Y.J., Faraj,M., Tchernof,A. and Wing,S.S. The deubiquitinating enzyme USP19 modulates adipogenesis and potentiates high-fat-diet-induced obesity and glucose intolerance in mice Diabetologia (2019) 62, 136-146. PubMed Europe PubMed DOI
Gierisch,M.E., Pedot,G., Walser,F., Lopez-Garcia,L.A., Jaaks,P., Niggli,F.K. and Schafer,B.W. USP19 deubiquitinates EWS-FLI1 to regulate Ewing sarcoma growth Sci Rep (2019) 9, 951-951. PubMed Europe PubMed DOI PMC EPMC
Lei,C.Q., Wu,X., Zhong,X., Jiang,L., Zhong,B. and Shu,H.B. USP19 Inhibits TNF-alpha- and IL-1beta-triggered NF-kappaB activation by deubiquitinating TAK1 J Immunol (2019) 203, 259-268. PubMed Europe PubMed DOI

2018

Coyne,E.S., Bedard,N., Wykes,L., Stretch,C., Jammoul,S., Li,S., Zhang,K., Sladek,R.S., Bathe,O.F., Jagoe,R.T., Posner,B.I. and Wing,S.S. Knockout of USP19 deubiquitinating enzyme prevents muscle wasting by modulating insulin and glucocorticoid signaling Endocrinology (2018) 159, 2966-2977. PubMed Europe PubMed DOI K

2017

Wu,M., Tu,H.Q., Chang,Y., Tan,B., Wang,G., Zhou,J., Wang,L., Mu,R. and Zhang,W.N. USP19 deubiquitinates HDAC1/2 to regulate DNA damage repair and control chromosomal stability Oncotarget (2017) 8, 2197-2208. PubMed Europe PubMed DOI

2016

Harada,K., Kato,M. and Nakamura,N. USP19-Mediated Deubiquitination Facilitates the Stabilization of HRD1 Ubiquitin Ligase Int J Mol Sci (2016) 17 PubMed Europe PubMed DOI
He,W.T., Zheng,X.M., Zhang,Y.H., Gao,Y.G., Song,A.X., van der Goot,F.G. and Hu,H.Y. Cytoplasmic ubiquitin-specific protease 19 (USP19) modulates aggregation of polyglutamine-expanded ataxin-3 and huntingtin through the HSP90 chaperone PLoS ONE (2016) 11, e0147515-e0147515. PubMed Europe PubMed DOI PMC EPMC
Jin,S., Tian,S., Chen,Y., Zhang,C., Xie,W., Xia,X., Cui,J. and Wang,R.F. USP19 modulates autophagy and antiviral immune responses by deubiquitinating beclin-1 EMBO J (2016) 35, 866-880. PubMed Europe PubMed DOI
Lim,K.H., Choi,J.H., Park,J.H., Cho,H.J., Park,J.J., Lee,E.J., Li,L., Choi,Y.K. and Baek,K.H. Ubiquitin specific protease 19 involved in transcriptional repression of retinoic acid receptor by stabilizing CORO2A Oncotarget (2016) 7, 34759-34772. PubMed Europe PubMed DOI
Wing,S.S. Deubiquitinating enzymes in skeletal muscle atrophy-an essential role for USP19 Int J Biochem Cell Biol (2016) 79, 462-468. PubMed Europe PubMed DOI

2015

Wiles,B., Miao,M., Coyne,E., Larose,L., Cybulsky,A.V. and Wing,S.S. USP19 deubiquitinating enzyme inhibits muscle cell differentiation by suppressing unfolded-protein response signaling Mol Biol Cell (2015) 26, 913-923. PubMed Europe PubMed DOI

2014

Lee,J.G., Kim,W., Gygi,S. and Ye,Y. Characterization of the deubiquitinating activity of USP19 and its role in endoplasmic reticulum-associated degradation J Biol Chem (2014) 289, 3510-3517. PubMed Europe PubMed DOI
Nakamura,N., Harada,K., Kato,M. and Hirose,S. Ubiquitin-specific protease 19 regulates the stability of the E3 ubiquitin ligase MARCH6 Exp Cell Res (2014) 328, 207-216. PubMed Europe PubMed DOI

2013

Velasco,K., Zhao,B., Callegari,S., Altun,M., Liu,H., Hassink,G., Masucci,M.G. and Lindsten,K. An N-terminal SIAH-interacting motif regulates the stability of the ubiquitin specific protease (USP)-19 Biochem Biophys Res Commun (2013) 433, 390-395. PubMed Europe PubMed DOI

2012

Altun,M., Zhao,B., Velasco,K., Liu,H., Hassink,G., Paschke,J., Pereira,T. and Lindsten,K. Ubiquitin-specific protease 19 (USP19) regulates hypoxia-inducible factor 1alpha (HIF-1alpha) during hypoxia J Biol Chem (2012) 287, 1962-1969. PubMed Europe PubMed DOI
Iphofer,A., Kummer,A., Nimtz,M., Ritter,A., Arnold,T., Frank,R., van den Heuvel,J., Kessler,B.M., Jansch,L. and Franke,R. Profiling ubiquitin linkage specificities of deubiquitinating enzymes with branched ubiquitin isopeptide probes Chembiochem (2012) 13, 1416-1420. PubMed Europe PubMed DOI P

2011

Lu,Y., Bedard,N., Chevalier,S. and Wing,S.S. Identification of distinctive patterns of USP19-mediated growth regulation in normal and malignant cells PLoS ONE (2011) 6, e15936-e15936. PubMed Europe PubMed DOI PMC EPMC K
Mei,Y., Hahn,A.A., Hu,S. and Yang,X. The USP19 deubiquitinase regulates the stability of c-IAP1 and c-IAP2 J Biol Chem (2011) 286, 35380-35387. PubMed Europe PubMed DOI
Ogawa,M., Yamaji,R., Higashimura,Y., Harada,N., Ashida,H., Nakano,Y. and Inui,H. 17beta-estradiol represses myogenic differentiation by increasing ubiquitin-specific peptidase 19 through estrogen receptor alpha J Biol Chem (2011) 286, 41455-41465. PubMed Europe PubMed DOI

2009

Hassink,G.C., Zhao,B., Sompallae,R., Altun,M., Gastaldello,S., Zinin,N.V., Masucci,M.G. and Lindsten,K. The ER-resident ubiquitin-specific protease 19 participates in the UPR and rescues ERAD substrates EMBO Rep (2009) 10, 755-761. PubMed Europe PubMed DOI PMC EPMC

2005

[YEAR:23-11-2005]Combaret,L., Adegoke,O.A., Bedard,N., Baracos,V., Attaix,D. and Wing,S.S. USP19 is a ubiquitin-specific protease regulated in rat skeletal muscle during catabolic states Am J Physiol Endocrinol Metab (23-11-2005) 288, E693-E700. PubMed Europe PubMed DOI