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Literature for peptidase C19.024: ubiquitin-specific peptidase 19

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Literature Substrates

(Topics flags: P Specificity, I Inhibitor, K Knockout, L Localization, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Picard,F., Nonaka,T., Belotti,E., Osseni,A., Errazuriz-Cerda,E., Jost-Mousseau,C., Bernard,E., Conjard-Duplany,A., Bohl,D., Hasegawa,M., Raoul,C., Galli,T., Schaeffer,L. and Leblanc,P.
    Enhanced secretion of the amyotrophic lateral sclerosis ALS-associated misfolded TDP-43 mediated by the ER-ubiquitin specific peptidase USP19
    Cell Mol Life Sci82, 76-76. PubMed  Europe PubMed DOI
  2. Shi,F., Li,G.J., Liu,Y., Zhou,H.M., Zhang,Y., Wei,S.Y., Zan,B.J., Gao,M., Chen,F.S., Li,B.X., Wang,B.Q., Dong,M.Y., Du,R.L. and Zhang,X.D.
    USP19 deficiency enhances T-cell-mediated antitumor immunity by promoting PD-L1 degradation in colorectal cancer
    Pharmacol Res107668-107668. PubMed  Europe PubMed DOI
  3. Zhang,D., Zhang,X., Chang,S., Zhao,Y. and Zhang,L.
    E2F1 activates USP19 to affect the stability of c-Myc to facilitate the progression of hepatocellular carcinoma
    Mutat Res830, 111902-111902. PubMed  Europe PubMed DOI  K
    4. 2024
  4. Bonelli,S., Lo Pinto,M., Ye,Y., Mueller,S.A., Lichtenthaler,S.F. and Scilabra,S.D.
    Proteomic characterization of ubiquitin carboxyl-terminal hydrolase 19 deficient cells reveals a role for USP19 in secretion of lysosomal proteins
    Mol Cell Proteomics100854-100854. PubMed  Europe PubMed DOI
  5. Ho,H.H. and Wing,S.S.
    alpha-Synuclein ubiquitination - functions in proteostasis and development of Lewy bodies
    Front Mol Neurosci17, 1498459-1498459. PubMed  Europe PubMed DOI  V
  6. Li,Y., Liu,X., Li,Y., Wang,J., Zhang,M., Xue,W. and Zhang,M.
    USP19 exerts a tumor-promoting role in diffuse large B cell lymphoma through stabilizing PARK7
    FEBS J291, 4757-4774. PubMed  Europe PubMed DOI  K
  7. Liu,J., Wang,K., Zhu,Q., Zhang,Y., Chen,Y., Lou,Z. and Yuan,J.
    USP19 regulates DNA methylation damage repair and confers temozolomide resistance through MGMT stabilization
    CNS Neurosci Ther30, e14711-e14711. PubMed  Europe PubMed DOI
  8. Olie,C.S., O'Brien,D.P., Jones,H.B.L., Liang,Z., Damianou,A., Sur-Erdem,I., Pinto-Fernandez,A., Raz,V. and Kessler,B.M.
    Deubiquitinases in muscle physiology and disorders
    Biochem Soc Trans52, 1085-1098. PubMed  Europe PubMed DOI  V
  9. Tyagi,A., Karapurkar,J.K., Colaco,J.C., Sarodaya,N., Antao,A.M., Kaushal,K., Haq,S., Chandrasekaran,A.P., Das,S., Singh,V., Hong,S.H., Suresh,B., Kim,K.S. and Ramakrishna,S.
    USP19 Negatively Regulates p53 and Promotes Cervical Cancer Progression
    Mol Biotechnol66, 2032-2045. PubMed  Europe PubMed DOI
  10. Wang,G., Dai,S., Chen,J., Zhang,K., Huang,C., Zhang,J., Xie,K., Lin,F., Wang,H., Gao,Y., Yin,L., Jiang,K., Miao,Y. and Lu,Z.
    USP19 potentiates autophagic cell death via inhibiting mTOR pathway through deubiquitinating NEK9 in pancreatic cancer
    Cell Death Differ PubMed  Europe PubMed DOI  K
  11. Weerawardhana,A., Herath,T.U.B., Gayan Chathuranga,W.A., Kim,T.H., Ekanayaka,P., Chathuranga,K., Kang,H.C., Jung,J.U. and Lee,J.S.
    SIAH1 modulates antiviral immune responses by targeting deubiquitinase USP19
    J Med Virol96, e29523-e29523. PubMed  Europe PubMed DOI
  12. Xu,J., Chen,S., Liu,D., Zhang,Q., Luo,T., Zhu,J., Zhou,L., Lin,Y., Pan,H., Chen,Y., Zhao,Q., Wang,T., Andrea,S., Nashan,B., Stefan,T.G., Cai,C., Cui,J., He,X. and Guo,Z.
    Suppression of Hepatocyte Ferroptosis via USP19-Mediated Deubiquitination of SLC7A11 in Ischemia-Free Liver Transplantation
    Adv Sci (Weinh)e2406200-e2406200. PubMed  Europe PubMed DOI
  13. Yan,X.H., Zhu,Y.N. and Zhu,Y.T.
    USP19 Stabilizes TAK1 to Regulate High Glucose/Free Fatty Acid-induced Dysfunction in HK-2 Cells
    Curr Med Sci44, 707-717. PubMed  Europe PubMed DOI  K
  14. Yu,W., Zhuang,S., Zhan,M., Chen,Y., Zhang,J., Chen,L., Tu,C., Zheng,L. and Chen,S.
    Deubiquitinating Enzyme USP19 Regulates Ferroptosis and Mitochondrial Damage in SH-SY5Y Cells by Targeting the NOX4 Protein
    J Alzheimers Dis100, 799-808. PubMed  Europe PubMed DOI  K
    15. 2023
  15. Schorova,L., Bedard,N., Khayachi,A., Ho,H.H., Bolivar-Pedroso,J., Huynh,J., Piccirelli,M., Wang,Y., Plourde,M., Luo,W., Del Cid-Pellitero,E., Shlaifer,I., Castellanos-Montiel,M.J., Yu,Z., Valenzuela,D.V.C., Lacalle-Aurioles,M., Kriz,A., Ye,Y., Durcan,T.M. and Wing,S.S.
    USP19 deubiquitinase inactivation regulates alpha-synuclein ubiquitination and inhibits accumulation of Lewy body-like aggregates in mice
    NPJ Parkinsons Dis9, 157-157. PubMed  Europe PubMed DOI
  16. Tian,Z., Xu,C., He,W., Lin,Z., Zhang,W., Tao,K., Ding,R., Zhang,X. and Dou,K.
    The deubiquitinating enzyme USP19 facilitates hepatocellular carcinoma progression through stabilizing YAP
    Cancer Lett577, 216439-216439. PubMed  Europe PubMed DOI  K
  17. You,Y., Wang,H., Wang,Q., Yu,Z., Zhao,Z., Zhuang,L., Zeng,S., Zheng,J. and Wen,W.
    Silencing USP19 alleviates cigarette smoke extract-induced mitochondrial dysfunction in BEAS-2B cells by targeting FUNDC1
    Open Med (Wars)18, 20230798-20230798. PubMed  Europe PubMed DOI  K
  18. Zhang,X., Chen,X., Qian,F., Zhu,Y., He,G., Yang,J., Wu,X., Zhang,H., Yu,X. and Liu,X.
    Deubiquitinase USP19 modulates apoptotic calcium release and endoplasmic reticulum stress by deubiquitinating BAG6 in triple negative breast cancer
    Clin Transl Med13, e1398-e1398. PubMed  Europe PubMed DOI
    19. 2022
  19. Dhingra,R., Rabinovich-Nikitin,I., Rothman,S., Guberman,M., Gang,H., Margulets,V., Jassal,D.S., Alagarsamy,K.N., Dhingra,S., Valenzuela Ripoll,C., Billia,F., Diwan,A., Javaheri,A. and Kirshenbaum,L.A.
    Proteasomal Degradation of TRAF2 Mediates Mitochondrial Dysfunction in Doxorubicin-Cardiomyopathy
    Circulation146, 934-954. PubMed  Europe PubMed DOI
  20. Hu,S., Xiang,Y., Qiu,L., Wang,M. and Zhang,Y.
    Activation of the membrane-bound Nrf1 transcription factor by USP19, a ubiquitin-specific protease C-terminally anchored in the endoplasmic reticulum
    Biochim Biophys Acta Mol Cell Res1869, 119299-119299. PubMed  Europe PubMed DOI
  21. Rossi,F.A. and Rossi,M.
    Emerging Role of Ubiquitin-Specific Protease 19 in Oncogenesis and Cancer Development
    Front Cell Dev Biol10, 889166-889166. PubMed  Europe PubMed DOI  V
  22. Sarodaya,N., Tyagi,A., Kim,H.J., Colaco,J.C., Kang,J.S., Kim,W.J., Kim,K.S. and Ramakrishna,S.
    Deubiquitinase USP19 enhances phenylalanine hydroxylase protein stability and its enzymatic activity
    Cell Biol Toxicol PubMed  Europe PubMed DOI
    23. 2021
  23. Chai,P., Cheng,Y., Hou,C., Yin,L., Zhang,D., Hu,Y., Chen,Q., Zheng,P., Teng,J. and Chen,J.
    USP19 promotes hypoxia-induced mitochondrial division via FUNDC1 at ER-mitochondria contact sites
    J Cell Biol220, PubMed  Europe PubMed DOI
  24. Li,T., Tan,Y., Ouyang,S., He,J. and Liu,L.
    Resveratrol protects against myocardial ischemia-reperfusion injury via attenuating ferroptosis
    Gene808, 145968-145968. PubMed  Europe PubMed DOI  I
  25. Rossi,F.A., Enrique Steinberg,J.H., Calvo Roitberg,E.H., Joshi,M.U., Pandey,A., Abba,M.C., Dufrusine,B., Buglioni,S., De Laurenzi,V., Sala,G., Lattanzio,R., Espinosa,J.M. and Rossi,M.
    USP19 modulates cancer cell migration and invasion and acts as a novel prognostic marker in patients with early breast cancer
    Oncogenesis10, 28-28. PubMed  Europe PubMed DOI
  26. Zhao,X., Di,Q., Yu,J., Quan,J., Xiao,Y., Zhu,H., Li,H., Ling,J. and Chen,W.
    USP19 (ubiquitin specific peptidase 19) promotes TBK1 (TANK-binding kinase 1) degradation via chaperone-mediated autophagy
    Autophagy1-18. PubMed  Europe PubMed DOI
  27. Zhu,Y., Gu,L., Lin,X., Zhou,X., Lu,B., Liu,C., Lei,C., Zhou,F., Zhao,Q., Prochownik,E.V. and Li,Y.
    USP19 exacerbates lipogenesis and colorectal carcinogenesis by stabilizing ME1
    Cell Rep37, 110174-110174. PubMed  Europe PubMed DOI
    28. 2020
  28. Boscaro,C., Carotti,M., Albiero,M., Trenti,A., Fadini,G.P., Trevisi,L., Sandona,D., Cignarella,A. and Bolego,C.
    Non-genomic mechanisms in the estrogen regulation of glycolytic protein levels in endothelial cells
    FASEB J PubMed  Europe PubMed DOI  K  I
  29. Dong,Z., Guo,S., Wang,Y., Zhang,J., Luo,H., Zheng,G., Yang,D., Zhang,T., Yan,L., Song,L., Liu,K., Sun,Z., Meng,X., Zheng,Z., Zhang,J. and Zhao,Y.
    USP19 Enhances MMP2/MMP9-Mediated Tumorigenesis in Gastric Cancer
    Onco Targets Ther13, 8495-8510. PubMed  Europe PubMed DOI  L
  30. Liu,T., Wang,L., Liang,P., Wang,X., Liu,Y., Cai,J., She,Y., Wang,D., Wang,Z., Guo,Z., Bates,S., Xia,X., Huang,J. and Cui,J.
    USP19 suppresses inflammation and promotes M2-like macrophage polarization by manipulating NLRP3 function via autophagy
    Cell Mol Immunol PubMed  Europe PubMed DOI
    31. 2019
  31. Coyne,E.S., Bedard,N., Gong,Y.J., Faraj,M., Tchernof,A. and Wing,S.S.
    The deubiquitinating enzyme USP19 modulates adipogenesis and potentiates high-fat-diet-induced obesity and glucose intolerance in mice
    Diabetologia62, 136-146. PubMed  Europe PubMed DOI
  32. Gierisch,M.E., Pedot,G., Walser,F., Lopez-Garcia,L.A., Jaaks,P., Niggli,F.K. and Schafer,B.W.
    USP19 deubiquitinates EWS-FLI1 to regulate Ewing sarcoma growth
    Sci Rep9, 951-951. PubMed  Europe PubMed DOI
  33. Lei,C.Q., Wu,X., Zhong,X., Jiang,L., Zhong,B. and Shu,H.B.
    USP19 Inhibits TNF-alpha- and IL-1beta-triggered NF-kappaB activation by deubiquitinating TAK1
    J Immunol203, 259-268. PubMed  Europe PubMed DOI
    34. 2018
  34. Coyne,E.S., Bedard,N., Wykes,L., Stretch,C., Jammoul,S., Li,S., Zhang,K., Sladek,R.S., Bathe,O.F., Jagoe,R.T., Posner,B.I. and Wing,S.S.
    Knockout of USP19 deubiquitinating enzyme prevents muscle wasting by modulating insulin and glucocorticoid signaling
    Endocrinology159, 2966-2977. PubMed  Europe PubMed DOI  K
    35. 2017
  35. Wu,M., Tu,H.Q., Chang,Y., Tan,B., Wang,G., Zhou,J., Wang,L., Mu,R. and Zhang,W.N.
    USP19 deubiquitinates HDAC1/2 to regulate DNA damage repair and control chromosomal stability
    Oncotarget8, 2197-2208. PubMed  Europe PubMed DOI
    36. 2016
  36. Harada,K., Kato,M. and Nakamura,N.
    USP19-Mediated Deubiquitination Facilitates the Stabilization of HRD1 Ubiquitin Ligase
    Int J Mol Sci17, PubMed  Europe PubMed DOI
  37. He,W.T., Zheng,X.M., Zhang,Y.H., Gao,Y.G., Song,A.X., van der Goot,F.G. and Hu,H.Y.
    Cytoplasmic ubiquitin-specific protease 19 (USP19) modulates aggregation of polyglutamine-expanded ataxin-3 and huntingtin through the HSP90 chaperone
    PLoS ONE11, e0147515-e0147515. PubMed  Europe PubMed DOI
  38. Jin,S., Tian,S., Chen,Y., Zhang,C., Xie,W., Xia,X., Cui,J. and Wang,R.F.
    USP19 modulates autophagy and antiviral immune responses by deubiquitinating beclin-1
    EMBO J35, 866-880. PubMed  Europe PubMed DOI
  39. Lim,K.H., Choi,J.H., Park,J.H., Cho,H.J., Park,J.J., Lee,E.J., Li,L., Choi,Y.K. and Baek,K.H.
    Ubiquitin specific protease 19 involved in transcriptional repression of retinoic acid receptor by stabilizing CORO2A
    Oncotarget7, 34759-34772. PubMed  Europe PubMed DOI
  40. Wing,S.S.
    Deubiquitinating enzymes in skeletal muscle atrophy-an essential role for USP19
    Int J Biochem Cell Biol79, 462-468. PubMed  Europe PubMed DOI
    41. 2015
  41. Wiles,B., Miao,M., Coyne,E., Larose,L., Cybulsky,A.V. and Wing,S.S.
    USP19 deubiquitinating enzyme inhibits muscle cell differentiation by suppressing unfolded-protein response signaling
    Mol Biol Cell26, 913-923. PubMed  Europe PubMed DOI
    42. 2014
  42. Lee,J.G., Kim,W., Gygi,S. and Ye,Y.
    Characterization of the deubiquitinating activity of USP19 and its role in endoplasmic reticulum-associated degradation
    J Biol Chem289, 3510-3517. PubMed  Europe PubMed DOI
  43. Nakamura,N., Harada,K., Kato,M. and Hirose,S.
    Ubiquitin-specific protease 19 regulates the stability of the E3 ubiquitin ligase MARCH6
    Exp Cell Res328, 207-216. PubMed  Europe PubMed DOI
    44. 2013
  44. Velasco,K., Zhao,B., Callegari,S., Altun,M., Liu,H., Hassink,G., Masucci,M.G. and Lindsten,K.
    An N-terminal SIAH-interacting motif regulates the stability of the ubiquitin specific protease (USP)-19
    Biochem Biophys Res Commun433, 390-395. PubMed  Europe PubMed DOI
    45. 2012
  45. Altun,M., Zhao,B., Velasco,K., Liu,H., Hassink,G., Paschke,J., Pereira,T. and Lindsten,K.
    Ubiquitin-specific protease 19 (USP19) regulates hypoxia-inducible factor 1alpha (HIF-1alpha) during hypoxia
    J Biol Chem287, 1962-1969. PubMed  Europe PubMed DOI
  46. Iphofer,A., Kummer,A., Nimtz,M., Ritter,A., Arnold,T., Frank,R., van den Heuvel,J., Kessler,B.M., Jansch,L. and Franke,R.
    Profiling ubiquitin linkage specificities of deubiquitinating enzymes with branched ubiquitin isopeptide probes
    Chembiochem13, 1416-1420. PubMed  Europe PubMed DOI  P
    47. 2011
  47. Lu,Y., Bedard,N., Chevalier,S. and Wing,S.S.
    Identification of distinctive patterns of USP19-mediated growth regulation in normal and malignant cells
    PLoS ONE6, e15936-e15936. PubMed  Europe PubMed DOI  K
  48. Mei,Y., Hahn,A.A., Hu,S. and Yang,X.
    The USP19 deubiquitinase regulates the stability of c-IAP1 and c-IAP2
    J Biol Chem286, 35380-35387. PubMed  Europe PubMed DOI
  49. Ogawa,M., Yamaji,R., Higashimura,Y., Harada,N., Ashida,H., Nakano,Y. and Inui,H.
    17beta-estradiol represses myogenic differentiation by increasing ubiquitin-specific peptidase 19 through estrogen receptor alpha
    J Biol Chem286, 41455-41465. PubMed  Europe PubMed DOI
    50. 2009
  50. Hassink,G.C., Zhao,B., Sompallae,R., Altun,M., Gastaldello,S., Zinin,N.V., Masucci,M.G. and Lindsten,K.
    The ER-resident ubiquitin-specific protease 19 participates in the UPR and rescues ERAD substrates
    EMBO Rep10, 755-761. PubMed  Europe PubMed DOI
    51. 2005
  51. [YEAR:23-11-2005]Combaret,L., Adegoke,O.A., Bedard,N., Baracos,V., Attaix,D. and Wing,S.S.
    USP19 is a ubiquitin-specific protease regulated in rat skeletal muscle during catabolic states
    Am J Physiol Endocrinol Metab288, E693-E700. PubMed  Europe PubMed DOI

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