Literature for peptidase C19.024: ubiquitin-specific peptidase 19

(Topics flags: P Specificity, I Inhibitor, K Knockout, L Localization, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

2025
1. Fang,X., Fan,Y., Liu,N. and Huang,S.
   USP19 restores mitochondrial function in neurons by deubiquitinating FUS to alleviate trigeminal neuralgia
   Exp Brain Res (2025) 244, 13-13. PubMed  Europe PubMed DOI  K
2. Picard,F., Nonaka,T., Belotti,E., Osseni,A., Errazuriz-Cerda,E., Jost-Mousseau,C., Bernard,E., Conjard-Duplany,A., Bohl,D., Hasegawa,M., Raoul,C., Galli,T., Schaeffer,L. and Leblanc,P.
   Enhanced secretion of the amyotrophic lateral sclerosis ALS-associated misfolded TDP-43 mediated by the ER-ubiquitin specific peptidase USP19
   Cell Mol Life Sci (2025) 82, 76-76. PubMed  Europe PubMed DOI  PMC  EPMC
3. Shao,S., Li,W., Hong,Y., Zeng,R., Zhu,L., Yi,L., Li,Y., Wang,Y., Huang,H., Jiang,X. and Jin,X.
   ZDHHC2-Dependent Palmitoylation Dictates Ferroptosis and Castration Sensitivity in Prostate Cancer via Controlling ACSL4 Degradation and Lipid Peroxidation
   Adv Sci (Weinh) (2025) , e14077-e14077. PubMed  Europe PubMed DOI
4. Shi,F., Li,G.J., Liu,Y., Zhou,H.M., Zhang,Y., Wei,S.Y., Zan,B.J., Gao,M., Chen,F.S., Li,B.X., Wang,B.Q., Dong,M.Y., Du,R.L. and Zhang,X.D.
   USP19 deficiency enhances T-cell-mediated antitumor immunity by promoting PD-L1 degradation in colorectal cancer
   Pharmacol Res (2025) , 107668-107668. PubMed  Europe PubMed DOI
5. Zhang,D., Zhang,X., Chang,S., Zhao,Y. and Zhang,L.
   E2F1 activates USP19 to affect the stability of c-Myc to facilitate the progression of hepatocellular carcinoma
   Mutat Res (2025) 830, 111902-111902. PubMed  Europe PubMed DOI  K
2024
6. Bonelli,S., Lo Pinto,M., Ye,Y., Mueller,S.A., Lichtenthaler,S.F. and Scilabra,S.D.
   Proteomic characterization of ubiquitin carboxyl-terminal hydrolase 19 deficient cells reveals a role for USP19 in secretion of lysosomal proteins
   Mol Cell Proteomics (2024) , 100854-100854. PubMed  Europe PubMed DOI
7. Ho,H.H. and Wing,S.S.
   alpha-Synuclein ubiquitination - functions in proteostasis and development of Lewy bodies
   Front Mol Neurosci (2024) 17, 1498459-1498459. PubMed  Europe PubMed DOI  PMC  EPMC  V
8. Li,Y., Liu,X., Li,Y., Wang,J., Zhang,M., Xue,W. and Zhang,M.
   USP19 exerts a tumor-promoting role in diffuse large B cell lymphoma through stabilizing PARK7
   FEBS J (2024) 291, 4757-4774. PubMed  Europe PubMed DOI  K
9. Liu,J., Wang,K., Zhu,Q., Zhang,Y., Chen,Y., Lou,Z. and Yuan,J.
   USP19 regulates DNA methylation damage repair and confers temozolomide resistance through MGMT stabilization
   CNS Neurosci Ther (2024) 30, e14711-e14711. PubMed  Europe PubMed DOI  PMC  EPMC
10. Olie,C.S., O'Brien,D.P., Jones,H.B.L., Liang,Z., Damianou,A., Sur-Erdem,I., Pinto-Fernandez,A., Raz,V. and Kessler,B.M.
    Deubiquitinases in muscle physiology and disorders
    Biochem Soc Trans (2024) 52, 1085-1098. PubMed  Europe PubMed DOI  V
11. Tyagi,A., Karapurkar,J.K., Colaco,J.C., Sarodaya,N., Antao,A.M., Kaushal,K., Haq,S., Chandrasekaran,A.P., Das,S., Singh,V., Hong,S.H., Suresh,B., Kim,K.S. and Ramakrishna,S.
    USP19 Negatively Regulates p53 and Promotes Cervical Cancer Progression
    Mol Biotechnol (2024) 66, 2032-2045. PubMed  Europe PubMed DOI
12. Wang,G., Dai,S., Chen,J., Zhang,K., Huang,C., Zhang,J., Xie,K., Lin,F., Wang,H., Gao,Y., Yin,L., Jiang,K., Miao,Y. and Lu,Z.
    USP19 potentiates autophagic cell death via inhibiting mTOR pathway through deubiquitinating NEK9 in pancreatic cancer
    Cell Death Differ (2024) PubMed  Europe PubMed DOI  K
13. Weerawardhana,A., Herath,T.U.B., Gayan Chathuranga,W.A., Kim,T.H., Ekanayaka,P., Chathuranga,K., Kang,H.C., Jung,J.U. and Lee,J.S.
    SIAH1 modulates antiviral immune responses by targeting deubiquitinase USP19
    J Med Virol (2024) 96, e29523-e29523. PubMed  Europe PubMed DOI
14. Xu,J., Chen,S., Liu,D., Zhang,Q., Luo,T., Zhu,J., Zhou,L., Lin,Y., Pan,H., Chen,Y., Zhao,Q., Wang,T., Andrea,S., Nashan,B., Stefan,T.G., Cai,C., Cui,J., He,X. and Guo,Z.
    Suppression of Hepatocyte Ferroptosis via USP19-Mediated Deubiquitination of SLC7A11 in Ischemia-Free Liver Transplantation
    Adv Sci (Weinh) (2024) , e2406200-e2406200. PubMed  Europe PubMed DOI
15. Yan,X.H., Zhu,Y.N. and Zhu,Y.T.
    USP19 Stabilizes TAK1 to Regulate High Glucose/Free Fatty Acid-induced Dysfunction in HK-2 Cells
    Curr Med Sci (2024) 44, 707-717. PubMed  Europe PubMed DOI  K
16. Yu,W., Zhuang,S., Zhan,M., Chen,Y., Zhang,J., Chen,L., Tu,C., Zheng,L. and Chen,S.
    Deubiquitinating Enzyme USP19 Regulates Ferroptosis and Mitochondrial Damage in SH-SY5Y Cells by Targeting the NOX4 Protein
    J Alzheimers Dis (2024) 100, 799-808. PubMed  Europe PubMed DOI  K
2023
17. Schorova,L., Bedard,N., Khayachi,A., Ho,H.H., Bolivar-Pedroso,J., Huynh,J., Piccirelli,M., Wang,Y., Plourde,M., Luo,W., Del Cid-Pellitero,E., Shlaifer,I., Castellanos-Montiel,M.J., Yu,Z., Valenzuela,D.V.C., Lacalle-Aurioles,M., Kriz,A., Ye,Y., Durcan,T.M. and Wing,S.S.
    USP19 deubiquitinase inactivation regulates alpha-synuclein ubiquitination and inhibits accumulation of Lewy body-like aggregates in mice
    NPJ Parkinsons Dis (2023) 9, 157-157. PubMed  Europe PubMed DOI  PMC  EPMC
18. Tian,Z., Xu,C., He,W., Lin,Z., Zhang,W., Tao,K., Ding,R., Zhang,X. and Dou,K.
    The deubiquitinating enzyme USP19 facilitates hepatocellular carcinoma progression through stabilizing YAP
    Cancer Lett (2023) 577, 216439-216439. PubMed  Europe PubMed DOI  K
19. You,Y., Wang,H., Wang,Q., Yu,Z., Zhao,Z., Zhuang,L., Zeng,S., Zheng,J. and Wen,W.
    Silencing USP19 alleviates cigarette smoke extract-induced mitochondrial dysfunction in BEAS-2B cells by targeting FUNDC1
    Open Med (Wars) (2023) 18, 20230798-20230798. PubMed  Europe PubMed DOI  PMC  EPMC  K
20. Zhang,X., Chen,X., Qian,F., Zhu,Y., He,G., Yang,J., Wu,X., Zhang,H., Yu,X. and Liu,X.
    Deubiquitinase USP19 modulates apoptotic calcium release and endoplasmic reticulum stress by deubiquitinating BAG6 in triple negative breast cancer
    Clin Transl Med (2023) 13, e1398-e1398. PubMed  Europe PubMed DOI  PMC  EPMC
2022
21. Dhingra,R., Rabinovich-Nikitin,I., Rothman,S., Guberman,M., Gang,H., Margulets,V., Jassal,D.S., Alagarsamy,K.N., Dhingra,S., Valenzuela Ripoll,C., Billia,F., Diwan,A., Javaheri,A. and Kirshenbaum,L.A.
    Proteasomal Degradation of TRAF2 Mediates Mitochondrial Dysfunction in Doxorubicin-Cardiomyopathy
    Circulation (2022) 146, 934-954. PubMed  Europe PubMed DOI
22. Hu,S., Xiang,Y., Qiu,L., Wang,M. and Zhang,Y.
    Activation of the membrane-bound Nrf1 transcription factor by USP19, a ubiquitin-specific protease C-terminally anchored in the endoplasmic reticulum
    Biochim Biophys Acta Mol Cell Res (2022) 1869, 119299-119299. PubMed  Europe PubMed DOI
23. Rossi,F.A. and Rossi,M.
    Emerging Role of Ubiquitin-Specific Protease 19 in Oncogenesis and Cancer Development
    Front Cell Dev Biol (2022) 10, 889166-889166. PubMed  Europe PubMed DOI  PMC  EPMC  V
24. Sarodaya,N., Tyagi,A., Kim,H.J., Colaco,J.C., Kang,J.S., Kim,W.J., Kim,K.S. and Ramakrishna,S.
    Deubiquitinase USP19 enhances phenylalanine hydroxylase protein stability and its enzymatic activity
    Cell Biol Toxicol (2022) PubMed  Europe PubMed DOI
2021
25. Chai,P., Cheng,Y., Hou,C., Yin,L., Zhang,D., Hu,Y., Chen,Q., Zheng,P., Teng,J. and Chen,J.
    USP19 promotes hypoxia-induced mitochondrial division via FUNDC1 at ER-mitochondria contact sites
    J Cell Biol (2021) 220 PubMed  Europe PubMed DOI  PMC  EPMC
26. Li,T., Tan,Y., Ouyang,S., He,J. and Liu,L.
    Resveratrol protects against myocardial ischemia-reperfusion injury via attenuating ferroptosis
    Gene (2021) 808, 145968-145968. PubMed  Europe PubMed DOI  I
27. Rossi,F.A., Enrique Steinberg,J.H., Calvo Roitberg,E.H., Joshi,M.U., Pandey,A., Abba,M.C., Dufrusine,B., Buglioni,S., De Laurenzi,V., Sala,G., Lattanzio,R., Espinosa,J.M. and Rossi,M.
    USP19 modulates cancer cell migration and invasion and acts as a novel prognostic marker in patients with early breast cancer
    Oncogenesis (2021) 10, 28-28. PubMed  Europe PubMed DOI  PMC  EPMC
28. Zhao,X., Di,Q., Yu,J., Quan,J., Xiao,Y., Zhu,H., Li,H., Ling,J. and Chen,W.
    USP19 (ubiquitin specific peptidase 19) promotes TBK1 (TANK-binding kinase 1) degradation via chaperone-mediated autophagy
    Autophagy (2021) , 1-18. PubMed  Europe PubMed DOI
29. Zhu,Y., Gu,L., Lin,X., Zhou,X., Lu,B., Liu,C., Lei,C., Zhou,F., Zhao,Q., Prochownik,E.V. and Li,Y.
    USP19 exacerbates lipogenesis and colorectal carcinogenesis by stabilizing ME1
    Cell Rep (2021) 37, 110174-110174. PubMed  Europe PubMed DOI
2020
30. Boscaro,C., Carotti,M., Albiero,M., Trenti,A., Fadini,G.P., Trevisi,L., Sandona,D., Cignarella,A. and Bolego,C.
    Non-genomic mechanisms in the estrogen regulation of glycolytic protein levels in endothelial cells
    FASEB J (2020) PubMed  Europe PubMed DOI  K  I
31. Dong,Z., Guo,S., Wang,Y., Zhang,J., Luo,H., Zheng,G., Yang,D., Zhang,T., Yan,L., Song,L., Liu,K., Sun,Z., Meng,X., Zheng,Z., Zhang,J. and Zhao,Y.
    USP19 Enhances MMP2/MMP9-Mediated Tumorigenesis in Gastric Cancer
    Onco Targets Ther (2020) 13, 8495-8510. PubMed  Europe PubMed DOI  PMC  EPMC  L
32. Liu,T., Wang,L., Liang,P., Wang,X., Liu,Y., Cai,J., She,Y., Wang,D., Wang,Z., Guo,Z., Bates,S., Xia,X., Huang,J. and Cui,J.
    USP19 suppresses inflammation and promotes M2-like macrophage polarization by manipulating NLRP3 function via autophagy
    Cell Mol Immunol (2020) PubMed  Europe PubMed DOI
2019
33. Coyne,E.S., Bedard,N., Gong,Y.J., Faraj,M., Tchernof,A. and Wing,S.S.
    The deubiquitinating enzyme USP19 modulates adipogenesis and potentiates high-fat-diet-induced obesity and glucose intolerance in mice
    Diabetologia (2019) 62, 136-146. PubMed  Europe PubMed DOI
34. Gierisch,M.E., Pedot,G., Walser,F., Lopez-Garcia,L.A., Jaaks,P., Niggli,F.K. and Schafer,B.W.
    USP19 deubiquitinates EWS-FLI1 to regulate Ewing sarcoma growth
    Sci Rep (2019) 9, 951-951. PubMed  Europe PubMed DOI  PMC  EPMC
35. Lei,C.Q., Wu,X., Zhong,X., Jiang,L., Zhong,B. and Shu,H.B.
    USP19 Inhibits TNF-alpha- and IL-1beta-triggered NF-kappaB activation by deubiquitinating TAK1
    J Immunol (2019) 203, 259-268. PubMed  Europe PubMed DOI
2018
36. Coyne,E.S., Bedard,N., Wykes,L., Stretch,C., Jammoul,S., Li,S., Zhang,K., Sladek,R.S., Bathe,O.F., Jagoe,R.T., Posner,B.I. and Wing,S.S.
    Knockout of USP19 deubiquitinating enzyme prevents muscle wasting by modulating insulin and glucocorticoid signaling
    Endocrinology (2018) 159, 2966-2977. PubMed  Europe PubMed DOI  K
2017
37. Wu,M., Tu,H.Q., Chang,Y., Tan,B., Wang,G., Zhou,J., Wang,L., Mu,R. and Zhang,W.N.
    USP19 deubiquitinates HDAC1/2 to regulate DNA damage repair and control chromosomal stability
    Oncotarget (2017) 8, 2197-2208. PubMed  Europe PubMed DOI
2016
38. Harada,K., Kato,M. and Nakamura,N.
    USP19-Mediated Deubiquitination Facilitates the Stabilization of HRD1 Ubiquitin Ligase
    Int J Mol Sci (2016) 17 PubMed  Europe PubMed DOI
39. He,W.T., Zheng,X.M., Zhang,Y.H., Gao,Y.G., Song,A.X., van der Goot,F.G. and Hu,H.Y.
    Cytoplasmic ubiquitin-specific protease 19 (USP19) modulates aggregation of polyglutamine-expanded ataxin-3 and huntingtin through the HSP90 chaperone
    PLoS ONE (2016) 11, e0147515-e0147515. PubMed  Europe PubMed DOI  PMC  EPMC
40. Jin,S., Tian,S., Chen,Y., Zhang,C., Xie,W., Xia,X., Cui,J. and Wang,R.F.
    USP19 modulates autophagy and antiviral immune responses by deubiquitinating beclin-1
    EMBO J (2016) 35, 866-880. PubMed  Europe PubMed DOI
41. Lim,K.H., Choi,J.H., Park,J.H., Cho,H.J., Park,J.J., Lee,E.J., Li,L., Choi,Y.K. and Baek,K.H.
    Ubiquitin specific protease 19 involved in transcriptional repression of retinoic acid receptor by stabilizing CORO2A
    Oncotarget (2016) 7, 34759-34772. PubMed  Europe PubMed DOI
42. Wing,S.S.
    Deubiquitinating enzymes in skeletal muscle atrophy-an essential role for USP19
    Int J Biochem Cell Biol (2016) 79, 462-468. PubMed  Europe PubMed DOI
2015
43. Wiles,B., Miao,M., Coyne,E., Larose,L., Cybulsky,A.V. and Wing,S.S.
    USP19 deubiquitinating enzyme inhibits muscle cell differentiation by suppressing unfolded-protein response signaling
    Mol Biol Cell (2015) 26, 913-923. PubMed  Europe PubMed DOI
2014
44. Lee,J.G., Kim,W., Gygi,S. and Ye,Y.
    Characterization of the deubiquitinating activity of USP19 and its role in endoplasmic reticulum-associated degradation
    J Biol Chem (2014) 289, 3510-3517. PubMed  Europe PubMed DOI
45. Nakamura,N., Harada,K., Kato,M. and Hirose,S.
    Ubiquitin-specific protease 19 regulates the stability of the E3 ubiquitin ligase MARCH6
    Exp Cell Res (2014) 328, 207-216. PubMed  Europe PubMed DOI
2013
46. Velasco,K., Zhao,B., Callegari,S., Altun,M., Liu,H., Hassink,G., Masucci,M.G. and Lindsten,K.
    An N-terminal SIAH-interacting motif regulates the stability of the ubiquitin specific protease (USP)-19
    Biochem Biophys Res Commun (2013) 433, 390-395. PubMed  Europe PubMed DOI
2012
47. Altun,M., Zhao,B., Velasco,K., Liu,H., Hassink,G., Paschke,J., Pereira,T. and Lindsten,K.
    Ubiquitin-specific protease 19 (USP19) regulates hypoxia-inducible factor 1alpha (HIF-1alpha) during hypoxia
    J Biol Chem (2012) 287, 1962-1969. PubMed  Europe PubMed DOI
48. Iphofer,A., Kummer,A., Nimtz,M., Ritter,A., Arnold,T., Frank,R., van den Heuvel,J., Kessler,B.M., Jansch,L. and Franke,R.
    Profiling ubiquitin linkage specificities of deubiquitinating enzymes with branched ubiquitin isopeptide probes
    Chembiochem (2012) 13, 1416-1420. PubMed  Europe PubMed DOI  P
2011
49. Lu,Y., Bedard,N., Chevalier,S. and Wing,S.S.
    Identification of distinctive patterns of USP19-mediated growth regulation in normal and malignant cells
    PLoS ONE (2011) 6, e15936-e15936. PubMed  Europe PubMed DOI  PMC  EPMC  K
50. Mei,Y., Hahn,A.A., Hu,S. and Yang,X.
    The USP19 deubiquitinase regulates the stability of c-IAP1 and c-IAP2
    J Biol Chem (2011) 286, 35380-35387. PubMed  Europe PubMed DOI
51. Ogawa,M., Yamaji,R., Higashimura,Y., Harada,N., Ashida,H., Nakano,Y. and Inui,H.
    17beta-estradiol represses myogenic differentiation by increasing ubiquitin-specific peptidase 19 through estrogen receptor alpha
    J Biol Chem (2011) 286, 41455-41465. PubMed  Europe PubMed DOI
2009
52. Hassink,G.C., Zhao,B., Sompallae,R., Altun,M., Gastaldello,S., Zinin,N.V., Masucci,M.G. and Lindsten,K.
    The ER-resident ubiquitin-specific protease 19 participates in the UPR and rescues ERAD substrates
    EMBO Rep (2009) 10, 755-761. PubMed  Europe PubMed DOI  PMC  EPMC
2005
53. [YEAR:23-11-2005]Combaret,L., Adegoke,O.A., Bedard,N., Baracos,V., Attaix,D. and Wing,S.S.
    USP19 is a ubiquitin-specific protease regulated in rat skeletal muscle during catabolic states
    Am J Physiol Endocrinol Metab (23-11-2005) 288, E693-E700. PubMed  Europe PubMed DOI