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Literature for peptidase C19.021: ubiquitin-specific peptidase 16

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Literature Inhibitors

(Topics flags: A Assay, I Inhibitor. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Li,X., He,N., Lv,Y., Wang,H., Zhang,M., Zhai,H., Yang,Z., Yang,Y., Guo,D., Cao,Z. and Chen,Y.
    Broad-spectrum ubiquitin-specific protease inhibition as a mechanism for the cytotoxicity of YM155 in cancers
    Sci Rep (2025) 15, 11054-11054. PubMed  Europe PubMed DOI  PMC  EPMC  I
  2. Shi,L., Chen,C., Jian,X., Wang,Q., Shen,Y., Alajmi,A., Zhang,H., Shock,L.S., Chow,L.T. and Wang,H.
    Polycomb Repressive Complex 1 and USP16 localize to the mitochondrion and influence its function
    Proc Natl Acad Sci U S A (2025) 122, e2508812122-e2508812122. PubMed  Europe PubMed DOI  PMC  EPMC
  3. Su,Q., Qin,J.Q., Huang,Y., Dai,R.X., Wu,Q.Y., Mo,L.R., Wu,Q., Huang,W.Z., Yang,H.F., Liu,Y.C. and Pan,D.G.
    USP16 S-nitrosylation aggravates coronary microembolization-induced myocardial injury via repressing KDM1A-mediated glutathione homeostasis
    Nat Commun (2025) PubMed  Europe PubMed DOI
    4. 2024
  4. Ai,H., He,Z., Deng,Z., Chu,G.C., Shi,Q., Tong,Z., Li,J.B., Pan,M. and Liu,L.
    Structural and mechanistic basis for nucleosomal H2AK119 deubiquitination by single-subunit deubiquitinase USP16
    Nat Struct Mol Biol (2024) 31, 1745-1755. PubMed  Europe PubMed DOI
  5. Zhao,J., Hua,J., Zhan,Y., Chen,C., Liu,Y., Yang,L., Wang,H., Wang,H. and Li,J.
    O-GlcNAcylation stimulates the deubiquitination activity of USP16 and regulates cell cycle progression
    J Biol Chem (2024) 300, 107150-107150. PubMed  Europe PubMed DOI  PMC  EPMC
    6. 2023
  6. Gan,J., Pinto-Fernandez,A., Flierman,D., Akkermans,J.J.L.L., O'Brien,D.P., Greenwood,H., Scott,H.C., Fritz,G., Knobeloch,K.P., Neefjes,J., van Dam,H., Ovaa,H., Ploegh,H.L., Kessler,B.M., Geurink,P.P. and Sapmaz,A.
    USP16 is an ISG15 cross-reactive deubiquitinase that targets pro-ISG15 and ISGylated proteins involved in metabolism
    Proc Natl Acad Sci U S A (2023) 120, e2315163120-e2315163120. PubMed  Europe PubMed DOI  PMC  EPMC
  7. O'Dea,R., Kazi,N., Hoffmann-Benito,A., Zhao,Z., Recknagel,S., Wendrich,K., Janning,P. and Gersch,M.
    Molecular basis for ubiquitin/Fubi cross-reactivity in USP16 and USP36
    Nat Chem Biol (2023) 19, 1394-1405. PubMed  Europe PubMed DOI
  8. Tong,G., Chen,Y., Chen,X., Fan,J., Zhu,K., Hu,Z., Li,S., Zhu,J., Feng,J., Wu,Z., Hu,Z., Zhou,B., Jin,L., Chen,H., Shen,J., Cong,W. and Li,X.
    FGF18 alleviates hepatic ischemia-reperfusion injury via the USP16-mediated KEAP1/Nrf2 signaling pathway in male mice
    Nat Commun (2023) 14, 6107-6107. PubMed  Europe PubMed DOI  PMC  EPMC
  9. Wang,Q. and Qiu,H.
    Deubiquitinase USP16 induces gouty arthritis via Drp1-dependent mitochondrial fission and NLRP3 inflammasome activation
    Arthritis Res Ther (2023) 25, 126-126. PubMed  Europe PubMed DOI  PMC  EPMC
  10. Zheng,J., Chen,C., Guo,C., Caba,C., Tong,Y. and Wang,H.
    The Pleiotropic Ubiquitin-Specific Peptidase 16 and Its Many Substrates
    Cells (2023) 12 PubMed  Europe PubMed DOI  PMC  EPMC
    11. 2022
  11. Rong,Y., Zhu,Y.Z., Yu,J.L., Wu,Y.W., Ji,S.Y., Zhou,Y., Jiang,Y., Jin,J., Fan,H.Y., Shen,L. and Sha,Q.Q.
    USP16-mediated histone H2A lysine-119 deubiquitination during oocyte maturation is a prerequisite for zygotic genome activation
    Nucleic Acids Res (2022) 50, 5599-5616. PubMed  Europe PubMed DOI  PMC  EPMC
    12. 2021
  12. Ge,J., Yu,W., Li,J., Ma,H., Wang,P., Zhou,Y., Wang,Y., Zhang,J. and Shi,G.
    USP16 regulates castration-resistant prostate cancer cell proliferation by deubiquitinating and stablizing c-Myc
    J Exp Clin Cancer Res (2021) 40, 59-59. PubMed  Europe PubMed DOI  PMC  EPMC
    13. 2020
  13. Montellese,C., van den Heuvel,J., Ashiono,C., Dorner,K., Melnik,A., Jonas,S., Zemp,I., Picotti,P., Gillet,L.C. and Kutay,U.
    USP16 counteracts mono-ubiquitination of RPS27a and promotes maturation of the 40S ribosomal subunit
    elife (2020) 9 PubMed  Europe PubMed DOI  PMC  EPMC
  14. Wen,Y., He,H., Liu,H., An,Q., Wang,D., Ding,X., Shi,Q., Feng,Y., Wang,E., Lei,C., Zhang,Z. and Huang,Y.
    Copy number variation of the USP16 gene and its association with milk traits in Chinese Holstein cattle
    Anim Biotechnol (2020) , 1-6. PubMed  Europe PubMed DOI
  15. Yang,Y., Li,J. and Geng,Y.
    Exosomes derived from chronic lymphocytic leukaemia cells transfer miR-146a to induce the transition of mesenchymal stromal cells into cancer-associated fibroblasts
    J Biochem (2020) 168, 491-498. PubMed  Europe PubMed DOI
    16. 2019
  16. Gjonaj,L., Sapmaz,A., Flierman,D., Janssen,G.M.C., van Veelen,P.A. and Ovaa,H.
    Development of a DUB-selective fluorogenic substrate
    Chem Sci (2019) 10, 10290-10296. PubMed  Europe PubMed DOI  PMC  EPMC  A
  17. Zhang,Y., Liu,R.B., Cao,Q., Fan,K.Q., Huang,L.J., Yu,J.S., Gao,Z.J., Huang,T., Zhong,J.Y., Mao,X.T., Wang,F., Xiao,P., Zhao,Y., Feng,X.H., Li,Y.Y. and Jin,J.
    USP16-mediated deubiquitination of calcineurin A controls peripheral T cell maintenance
    J Clin Invest (2019) 129, 2856-2871. PubMed  Europe PubMed DOI
    18. 2016
  18. Gu,Y., Jones,A.E., Yang,W., Liu,S., Dai,Q., Liu,Y., Swindle,C.S., Zhou,D., Zhang,Z., Ryan,T.M., Townes,T.M., Klug,C.A., Chen,D. and Wang,H.
    The histone H2A deubiquitinase Usp16 regulates hematopoiesis and hematopoietic stem cell function
    Proc Natl Acad Sci U S A (2016) 113, E51-E60. PubMed  Europe PubMed DOI
    19. 2015
  19. Zhuo,X., Guo,X., Zhang,X., Jing,G., Wang,Y., Chen,Q., Jiang,Q., Liu,J. and Zhang,C.
    Usp16 regulates kinetochore localization of Plk1 to promote proper chromosome alignment in mitosis
    J Cell Biol (2015) 210, 727-735. PubMed  Europe PubMed DOI  PMC  EPMC
    20. 2014
  20. Yang,W., Lee,Y.H., Jones,A.E., Woolnough,J.L., Zhou,D., Dai,Q., Wu,Q., Giles,K.E., Townes,T.M. and Wang,H.
    The histone H2A deubiquitinase Usp16 regulates embryonic stem cell gene expression and lineage commitment
    Nat Commun (2014) 5, 3818-3818. PubMed  Europe PubMed DOI
  21. Zhang,Z., Yang,H. and Wang,H.
    The histone H2A deubiquitinase USP16 interacts with HERC2 and fine-tunes cellular response to DNA damage
    J Biol Chem (2014) 289, 32883-32894. PubMed  Europe PubMed DOI
    22. 2013
  22. Xu,J.C., Dawson,V.L. and Dawson,T.M.
    Usp16: key controller of stem cells in Down syndrome
    EMBO J (2013) 32, 2788-2789. PubMed  Europe PubMed DOI
    23. 2012
  23. Jones,A., Xu,C., Min,J. and Wang,H.
    Ubiquitin specific peptidase 16
    [ISSN:978-0-12-407743-0] (2012) 3, 2090-2094. DOI
    24. 2011
  24. Faesen,A.C., Luna-Vargas,M.P., Geurink,P.P., Clerici,M., Merkx,R., van Dijk,W.J., Hameed,D.S., El Oualid,F., Ovaa,H. and Sixma,T.K.
    The differential modulation of USP activity by internal regulatory domains, interactors and eight ubiquitin chain types
    Chem Biol (2011) 18, 1550-1561. PubMed  Europe PubMed DOI
    25. 2007
  25. Pai,M.T., Tzeng,S.R., Kovacs,J.J., Keaton,M.A., Li,S.S., Yao,T.P. and Zhou,P.
    Solution structure of the Ubp-M BUZ domain, a highly specific protein module that recognizes the C-terminal tail of free ubiquitin
    J Mol Biol (2007) 370, 290-302. PubMed  Europe PubMed DOI
    26. 1999
  26. [YEAR:16-3-1999]Cai,S.Y., Babbitt,R.W. and Marchesi,V.T.
    A mutant deubiquitinating enzyme (Ubp-M) associates with mitotic chromosomes and blocks cell division
    Proc Natl Acad Sci U S A (16-3-1999) 96, 2828-2833. PubMed  Europe PubMed DOI  PMC  EPMC

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