Literature for peptidase C19.020: ubiquitin-specific peptidase 12

(Topics flags: S Structure, I Inhibitor, K Knockout, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

2025
1. Yang,H., Sun,T., Sun,Z., Wang,H., Liu,D., Wu,D., Qin,T. and Zhou,M.
   Unravelling the role of ubiquitin-specific proteases in breast carcinoma: insights into tumour progression and immune microenvironment modulation
   World J Surg Oncol23, 60-60. PubMed  Europe PubMed DOI  V
2024
2. Jiang,L., Qi,X., Lai,M., Zhou,J., Yuan,M., You,J., Liu,Q., Pan,J., Zhao,L., Ying,M., Ji,J., Li,K., Zhang,Y., Pan,W., He,Q., Yang,B. and Cao,J.
   WDR20 prevents hepatocellular carcinoma senescence by orchestrating the simultaneous USP12/46-mediated deubiquitination of c-Myc
   Proc Natl Acad Sci U S A121, e2407904121-e2407904121. PubMed  Europe PubMed DOI  K
3. Wang,Z., Sun,S., Huang,L., Chen,X., Xu,H., Ma,H., Xiao,M. and Wang,L.
   METTL3/YTHDF1-mediated m(6)A modification stabilizes USP12 to deubiquitinate FOXO3 and promote apoptosis in sepsis-induced myocardial dysfunction
   Mol Immunol177, 17-31. PubMed  Europe PubMed DOI
4. Yu,K., Wang,G.M., Guo,S.S., Bassermann,F. and Fassler,R.
   The USP12/46 deubiquitinases protect integrins from ESCRT-mediated lysosomal degradation
   EMBO Rep PubMed  Europe PubMed DOI
5. Zhang,P., Liu,D., Zang,Y., Wang,J., Liu,Z., Zhu,J., Li,X. and Ding,Y.
   USP12 facilitates gastric cancer progression via stabilizing YAP
   Cell Death Discov10, 174-174. PubMed  Europe PubMed DOI
2023
6. Chen,C., Xue,N., Liu,K., He,Q., Wang,C., Guo,Y., Tian,J., Liu,X., Pan,Y. and Chen,G.
   USP12 promotes nonsmall cell lung cancer progression through deubiquitinating and stabilizing RRM2
   Mol Carcinog62, 1518-1530. PubMed  Europe PubMed DOI
7. Fu,Y., Zhan,X., You,X., Nie,D., Mai,H., Chen,Y., He,S., Sheng,J., Zeng,Z., Li,H., Li,J. and Hu,S.
   USP12 promotes antiviral responses by deubiquitinating and stabilizing IFI16
   PLoS Pathog19, e1011480-e1011480. PubMed  Europe PubMed DOI  K
8. Fu,Y., Zhan,X., You,X., Nie,D., Mai,H., Chen,Y., He,S., Sheng,J., Zeng,Z., Li,H., Li,J. and Hu,S.
   Correction: USP12 promotes antiviral responses by deubiquitinating and stabilizing IFI16
   PLoS Pathog19, e1011827-e1011827. PubMed  Europe PubMed DOI
2022
9. Choi,H.S., Lim,E.S. and Baek,K.H.
   Deubiquitinating Enzyme USP12 Regulates the Pro-Apoptosis Protein Bax
   Int J Mol Sci23, PubMed  Europe PubMed DOI
10. Zhan,X., He,Q., Sheng,J., Jiang,X., Lin,L., Huang,Y., He,S., Chen,Y., Li,L., Zeng,Z., Hu,S., Wang,P. and Zhang,Y.
    USP12 positively regulates M-MDSC function to inhibit anti-tumor immunity through deubiquitinating and stabilizing p65
    Immunology PubMed  Europe PubMed DOI
2021
11. Fu,Y., Wang,P., Zhao,J., Tan,Y., Sheng,J., He,S., Du,X., Huang,Y., Yang,Y., Li,J., Cai,Y., Liu,Y. and Hu,S.
    USP12 promotes CD4(+) T cell responses through deubiquitinating and stabilizing BCL10
    Cell Death Differ PubMed  Europe PubMed DOI
12. Lu,P., Xu,Y., Sheng,Z.Y., Peng,X.G., Zhang,J.J., Wu,Q.H., Wu,Y.Q., Cheng,X.S. and Zhu,K.
    De-ubiquitination of p300 by USP12 Critically Enhances METTL3 Expression and Ang II-induced cardiac hypertrophy
    Exp Cell Res406, 112761-112761. PubMed  Europe PubMed DOI  K
13. Olazabal-Herrero,A., Bilbao-Arribas,M., Carlevaris,O., Sendino,M., Varela-Martinez,E., Jugo,B.M., Berra,E. and Rodriguez,J.A.
    The dystrophia myotonica WD repeat-containing protein DMWD and WDR20 differentially regulate USP12 deubiquitinase
    FEBS J PubMed  Europe PubMed DOI
14. Sheng,B., Wei,Z., Wu,X., Li,Y. and Liu,Z.
    USP12 promotes breast cancer angiogenesis by maintaining midkine stability
    Cell Death Dis12, 1074-1074. PubMed  Europe PubMed DOI  K
15. Yang,Z., Xu,G., Wang,B., Liu,Y., Zhang,L., Jing,T., Tang,M., Xu,X., Jiao,K., Xiang,L., Fu,Y., Tang,D., Zhang,X., Jin,W., Zhuang,G., Zhao,X. and Liu,Y.
    USP12 downregulation orchestrates a protumourigenic microenvironment and enhances lung tumour resistance to PD-1 blockade
    Nat Commun12, 4852-4852. PubMed  Europe PubMed DOI
2020
16. Liu,C., Li,X., Feng,G., Cao,M., Liu,F., Zhang,G. and Lu,Y.
    Downregulation of USP12 inhibits tumor growth via the p38/MAPK pathway in hepatocellular carcinoma
    Mol Med Rep22, 4899-4908. PubMed  Europe PubMed DOI
17. Rasaei,R., Sarodaya,N., Kim,K.S., Ramakrishna,S. and Hong,S.H.
    Importance of Deubiquitination in Macrophage-Mediated Viral Response and Inflammation
    Int J Mol Sci21, PubMed  Europe PubMed DOI  V
2018
18. Aron,R., Pellegrini,P., Green,E.W., Maddison,D.C., Opoku-Nsiah,K., Wong,J.S., Daub,A.C., Giorgini,F. and Finkbeiner,S.
    Deubiquitinase Usp12 functions noncatalytically to induce autophagy and confer neuroprotection in models of Huntington's disease
    Nat Commun9, 3191-3191. PubMed  Europe PubMed DOI
2017
19. Nayak,T.K., Alamuru-Yellapragada,N.P. and Parsa,K.V.
    Deubiquitinase USP12 promotes LPS induced macrophage responses through inhibition of IkappaBalpha
    Biochem Biophys Res Commun483, 69-74. PubMed  Europe PubMed DOI
2016
20. Dharadhar,S., Clerici,M., van Dijk,W.J., Fish,A. and Sixma,T.K.
    A conserved two-step binding for the UAF1 regulator to the USP12 deubiquitinating enzyme
    J Struct Biol196, 437-447. PubMed  Europe PubMed DOI  S
21. Jahan,A.S., Lestra,M., Swee,L.K., Fan,Y., Lamers,M.M., Tafesse,F.G., Theile,C.S., Spooner,E., Bruzzone,R., Ploegh,H.L. and Sanyal,S.
    Usp12 stabilizes the T-cell receptor complex at the cell surface during signaling
    Proc Natl Acad Sci U S A113, E705-E714. PubMed  Europe PubMed DOI  I
22. Li,H., Lim,K.S., Kim,H., Hinds,T.R., Jo,U., Mao,H., Weller,C.E., Sun,J., Chatterjee,C., D'Andrea,A.D. and Zheng,N.
    Allosteric activation of ubiquitin-specific proteases by beta-propeller proteins UAF1 and WDR20
    Mol Cell63, 249-260. PubMed  Europe PubMed DOI
23. Rodriguez,J.A.
    Description of USP12 nuclear export sequence
    Proc Natl Acad Sci U S A113, E3315-E3316. PubMed  Europe PubMed DOI
24. Tang,L.J., Li,Y., Liu,Y.L., Wang,J.M., Liu,D.W. and Tian,Q.B.
    USP12 regulates cell cycle progression by involving c-Myc, cyclin D2 and BMI-1
    Gene578, 92-99. PubMed  Europe PubMed DOI  K
2015
25. McClurg,U.L., Harle,V.J., Nabbi,A., Batalha-Pereira,A., Walker,S., Coffey,K., Gaughan,L., McCracken,S.R. and Robson,C.N.
    Ubiquitin-specific protease 12 interacting partners Uaf-1 and WDR20 are potential therapeutic targets in prostate cancer
    Oncotarget6, 37724-37736. PubMed  Europe PubMed DOI
2014
26. McClurg,U.L., Summerscales,E.E., Harle,V.J., Gaughan,L. and Robson,C.N.
    Deubiquitinating enzyme Usp12 regulates the interaction between the androgen receptor and the Akt pathway
    Oncotarget5, 7081-7092. PubMed  Europe PubMed
2013
27. Burska,U.L., Harle,V.J., Coffey,K., Darby,S., Ramsey,H., O'Neill,D., Logan,I.R., Gaughan,L. and Robson,C.N.
    Deubiquitinating enzyme Usp12 is a novel co-activator of the androgen receptor
    J Biol Chem288, 32641-32650. PubMed  Europe PubMed DOI
2011
28. Faesen,A.C., Luna-Vargas,M.P., Geurink,P.P., Clerici,M., Merkx,R., van Dijk,W.J., Hameed,D.S., El Oualid,F., Ovaa,H. and Sixma,T.K.
    The differential modulation of USP activity by internal regulatory domains, interactors and eight ubiquitin chain types
    Chem Biol18, 1550-1561. PubMed  Europe PubMed DOI
29. Joo,H.Y., Jones,A., Yang,C., Zhai,L., Smith,A.D., Zhang,Z., Chandrasekharan,M.B., Sun,Z.W., Renfrow,M.B., Wang,Y., Chang,C. and Wang,H.
    Regulation of histone H2A and H2B deubiquitination and Xenopus development by USP12 and USP46
    J Biol Chem286, 7190-7201. PubMed  Europe PubMed DOI
2010
30. Kee,Y., Yang,K., Cohn,M.A., Haas,W., Gygi,S.P. and D'Andrea,A.D.
    WDR20 regulates activity of the USP12 x UAF1 deubiquitinating enzyme complex
    J Biol Chem285, 11252-11257. PubMed  Europe PubMed DOI
1998
31. [YEAR:1-5-1998]Hansen-Hagge,T.E., Janssen,J.W., Hameister,H., Papa,F.R., Zechner,U., Seriu,T., Jauch,A., Becke,D., Hochstrasser,M. and Bartram,C.R.
    An evolutionarily conserved gene on human chromosome 5q33-q34, UBH1, encodes a novel deubiquitinating enzyme
    Genomics49, 411-418. PubMed  Europe PubMed DOI