Literature for peptidase C19.020: ubiquitin-specific peptidase 12

Summary Alignment Tree Sequences Sequence features Distribution Literature

(Topics flags: S Structure, I Inhibitor, K Knockout, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

2025

Yang,H., Sun,T., Sun,Z., Wang,H., Liu,D., Wu,D., Qin,T. and Zhou,M. Unravelling the role of ubiquitin-specific proteases in breast carcinoma: insights into tumour progression and immune microenvironment modulation World J Surg Oncol (2025) 23, 60-60. PubMed Europe PubMed DOI PMC EPMC V

2024

Jiang,L., Qi,X., Lai,M., Zhou,J., Yuan,M., You,J., Liu,Q., Pan,J., Zhao,L., Ying,M., Ji,J., Li,K., Zhang,Y., Pan,W., He,Q., Yang,B. and Cao,J. WDR20 prevents hepatocellular carcinoma senescence by orchestrating the simultaneous USP12/46-mediated deubiquitination of c-Myc Proc Natl Acad Sci U S A (2024) 121, e2407904121-e2407904121. PubMed Europe PubMed DOI K
Wang,Z., Sun,S., Huang,L., Chen,X., Xu,H., Ma,H., Xiao,M. and Wang,L. METTL3/YTHDF1-mediated m(6)A modification stabilizes USP12 to deubiquitinate FOXO3 and promote apoptosis in sepsis-induced myocardial dysfunction Mol Immunol (2024) 177, 17-31. PubMed Europe PubMed DOI
Yu,K., Wang,G.M., Guo,S.S., Bassermann,F. and Fassler,R. The USP12/46 deubiquitinases protect integrins from ESCRT-mediated lysosomal degradation EMBO Rep (2024) PubMed Europe PubMed DOI
Zhang,P., Liu,D., Zang,Y., Wang,J., Liu,Z., Zhu,J., Li,X. and Ding,Y. USP12 facilitates gastric cancer progression via stabilizing YAP Cell Death Discov (2024) 10, 174-174. PubMed Europe PubMed DOI PMC EPMC

2023

Chen,C., Xue,N., Liu,K., He,Q., Wang,C., Guo,Y., Tian,J., Liu,X., Pan,Y. and Chen,G. USP12 promotes nonsmall cell lung cancer progression through deubiquitinating and stabilizing RRM2 Mol Carcinog (2023) 62, 1518-1530. PubMed Europe PubMed DOI
Fu,Y., Zhan,X., You,X., Nie,D., Mai,H., Chen,Y., He,S., Sheng,J., Zeng,Z., Li,H., Li,J. and Hu,S. Correction: USP12 promotes antiviral responses by deubiquitinating and stabilizing IFI16 PLoS Pathog (2023) 19, e1011827-e1011827. PubMed Europe PubMed DOI PMC EPMC
Fu,Y., Zhan,X., You,X., Nie,D., Mai,H., Chen,Y., He,S., Sheng,J., Zeng,Z., Li,H., Li,J. and Hu,S. USP12 promotes antiviral responses by deubiquitinating and stabilizing IFI16 PLoS Pathog (2023) 19, e1011480-e1011480. PubMed Europe PubMed DOI PMC EPMC K

2022

Choi,H.S., Lim,E.S. and Baek,K.H. Deubiquitinating Enzyme USP12 Regulates the Pro-Apoptosis Protein Bax Int J Mol Sci (2022) 23 PubMed Europe PubMed DOI PMC EPMC
Zhan,X., He,Q., Sheng,J., Jiang,X., Lin,L., Huang,Y., He,S., Chen,Y., Li,L., Zeng,Z., Hu,S., Wang,P. and Zhang,Y. USP12 positively regulates M-MDSC function to inhibit anti-tumor immunity through deubiquitinating and stabilizing p65 Immunology (2022) PubMed Europe PubMed DOI

2021

Fu,Y., Wang,P., Zhao,J., Tan,Y., Sheng,J., He,S., Du,X., Huang,Y., Yang,Y., Li,J., Cai,Y., Liu,Y. and Hu,S. USP12 promotes CD4(+) T cell responses through deubiquitinating and stabilizing BCL10 Cell Death Differ (2021) PubMed Europe PubMed DOI
Lu,P., Xu,Y., Sheng,Z.Y., Peng,X.G., Zhang,J.J., Wu,Q.H., Wu,Y.Q., Cheng,X.S. and Zhu,K. De-ubiquitination of p300 by USP12 Critically Enhances METTL3 Expression and Ang II-induced cardiac hypertrophy Exp Cell Res (2021) 406, 112761-112761. PubMed Europe PubMed DOI K
Olazabal-Herrero,A., Bilbao-Arribas,M., Carlevaris,O., Sendino,M., Varela-Martinez,E., Jugo,B.M., Berra,E. and Rodriguez,J.A. The dystrophia myotonica WD repeat-containing protein DMWD and WDR20 differentially regulate USP12 deubiquitinase FEBS J (2021) PubMed Europe PubMed DOI
Sheng,B., Wei,Z., Wu,X., Li,Y. and Liu,Z. USP12 promotes breast cancer angiogenesis by maintaining midkine stability Cell Death Dis (2021) 12, 1074-1074. PubMed Europe PubMed DOI PMC EPMC K
Yang,Z., Xu,G., Wang,B., Liu,Y., Zhang,L., Jing,T., Tang,M., Xu,X., Jiao,K., Xiang,L., Fu,Y., Tang,D., Zhang,X., Jin,W., Zhuang,G., Zhao,X. and Liu,Y. USP12 downregulation orchestrates a protumourigenic microenvironment and enhances lung tumour resistance to PD-1 blockade Nat Commun (2021) 12, 4852-4852. PubMed Europe PubMed DOI PMC EPMC

2020

Liu,C., Li,X., Feng,G., Cao,M., Liu,F., Zhang,G. and Lu,Y. Downregulation of USP12 inhibits tumor growth via the p38/MAPK pathway in hepatocellular carcinoma Mol Med Rep (2020) 22, 4899-4908. PubMed Europe PubMed DOI
Rasaei,R., Sarodaya,N., Kim,K.S., Ramakrishna,S. and Hong,S.H. Importance of Deubiquitination in Macrophage-Mediated Viral Response and Inflammation Int J Mol Sci (2020) 21 PubMed Europe PubMed DOI PMC EPMC V

2018

Aron,R., Pellegrini,P., Green,E.W., Maddison,D.C., Opoku-Nsiah,K., Wong,J.S., Daub,A.C., Giorgini,F. and Finkbeiner,S. Deubiquitinase Usp12 functions noncatalytically to induce autophagy and confer neuroprotection in models of Huntington's disease Nat Commun (2018) 9, 3191-3191. PubMed Europe PubMed DOI PMC EPMC

2017

Nayak,T.K., Alamuru-Yellapragada,N.P. and Parsa,K.V. Deubiquitinase USP12 promotes LPS induced macrophage responses through inhibition of IkappaBalpha Biochem Biophys Res Commun (2017) 483, 69-74. PubMed Europe PubMed DOI

2016

Dharadhar,S., Clerici,M., van Dijk,W.J., Fish,A. and Sixma,T.K. A conserved two-step binding for the UAF1 regulator to the USP12 deubiquitinating enzyme J Struct Biol (2016) 196, 437-447. PubMed Europe PubMed DOI S
Jahan,A.S., Lestra,M., Swee,L.K., Fan,Y., Lamers,M.M., Tafesse,F.G., Theile,C.S., Spooner,E., Bruzzone,R., Ploegh,H.L. and Sanyal,S. Usp12 stabilizes the T-cell receptor complex at the cell surface during signaling Proc Natl Acad Sci U S A (2016) 113, E705-E714. PubMed Europe PubMed DOI I
Li,H., Lim,K.S., Kim,H., Hinds,T.R., Jo,U., Mao,H., Weller,C.E., Sun,J., Chatterjee,C., D'Andrea,A.D. and Zheng,N. Allosteric activation of ubiquitin-specific proteases by beta-propeller proteins UAF1 and WDR20 Mol Cell (2016) 63, 249-260. PubMed Europe PubMed DOI
Rodriguez,J.A. Description of USP12 nuclear export sequence Proc Natl Acad Sci U S A (2016) 113, E3315-E3316. PubMed Europe PubMed DOI PMC EPMC
Tang,L.J., Li,Y., Liu,Y.L., Wang,J.M., Liu,D.W. and Tian,Q.B. USP12 regulates cell cycle progression by involving c-Myc, cyclin D2 and BMI-1 Gene (2016) 578, 92-99. PubMed Europe PubMed DOI K

2015

McClurg,U.L., Harle,V.J., Nabbi,A., Batalha-Pereira,A., Walker,S., Coffey,K., Gaughan,L., McCracken,S.R. and Robson,C.N. Ubiquitin-specific protease 12 interacting partners Uaf-1 and WDR20 are potential therapeutic targets in prostate cancer Oncotarget (2015) 6, 37724-37736. PubMed Europe PubMed DOI

2014

McClurg,U.L., Summerscales,E.E., Harle,V.J., Gaughan,L. and Robson,C.N. Deubiquitinating enzyme Usp12 regulates the interaction between the androgen receptor and the Akt pathway Oncotarget (2014) 5, 7081-7092. PubMed Europe PubMed

2013

Burska,U.L., Harle,V.J., Coffey,K., Darby,S., Ramsey,H., O'Neill,D., Logan,I.R., Gaughan,L. and Robson,C.N. Deubiquitinating enzyme Usp12 is a novel co-activator of the androgen receptor J Biol Chem (2013) 288, 32641-32650. PubMed Europe PubMed DOI

2011

Faesen,A.C., Luna-Vargas,M.P., Geurink,P.P., Clerici,M., Merkx,R., van Dijk,W.J., Hameed,D.S., El Oualid,F., Ovaa,H. and Sixma,T.K. The differential modulation of USP activity by internal regulatory domains, interactors and eight ubiquitin chain types Chem Biol (2011) 18, 1550-1561. PubMed Europe PubMed DOI
Joo,H.Y., Jones,A., Yang,C., Zhai,L., Smith,A.D., Zhang,Z., Chandrasekharan,M.B., Sun,Z.W., Renfrow,M.B., Wang,Y., Chang,C. and Wang,H. Regulation of histone H2A and H2B deubiquitination and Xenopus development by USP12 and USP46 J Biol Chem (2011) 286, 7190-7201. PubMed Europe PubMed DOI

2010

Kee,Y., Yang,K., Cohn,M.A., Haas,W., Gygi,S.P. and D'Andrea,A.D. WDR20 regulates activity of the USP12 x UAF1 deubiquitinating enzyme complex J Biol Chem (2010) 285, 11252-11257. PubMed Europe PubMed DOI

1998

[YEAR:1-5-1998]Hansen-Hagge,T.E., Janssen,J.W., Hameister,H., Papa,F.R., Zechner,U., Seriu,T., Jauch,A., Becke,D., Hochstrasser,M. and Bartram,C.R. An evolutionarily conserved gene on human chromosome 5q33-q34, UBH1, encodes a novel deubiquitinating enzyme Genomics (1-5-1998) 49, 411-418. PubMed Europe PubMed DOI