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Literature for peptidase C19.019: ubiquitin-specific peptidase 1

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Literature Substrates

(Topics flags: M Mutation, T Target, I Inhibitor, K Knockout, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Hu,X., Wu,Y., Yao,M., Chen,Z. and Li,Q.
    The other side of the coin: protein deubiquitination by Ubiquitin-Specific Protease 1 in cancer progression and therapy
    Future Med Chem1-17. PubMed  Europe PubMed DOI  V
  2. Hui,Y.B. and Shang,G.N.
    NRF1 Transcriptionally Regulates USP1-Mediated Deubiquitination of AURKA to Facilitate Osteosarcoma Progression
    Mol Biotechnol PubMed  Europe PubMed DOI  K
  3. Jiang,S., Tang,Y., Ma,F., Niu,Y. and Sun,L.
    Ubiquitin-specific protease 1 facilitates tumor immune escape from natural killer cells and predicts the prognosis in small cell lung cancer
    Oncol Res33, 213-224. PubMed  Europe PubMed DOI
  4. Li,L., Fan,Z., Liu,M., Dong,H., Li,J., Li,Y., Song,Z., Liu,Y., Zhang,Z., Gu,X. and Zhang,T.
    USP1 promotes pancreatic cancer progression and autophagy by deubiquitinating ATG14
    J Biol Chem108190-108190. PubMed  Europe PubMed DOI  K
  5. Liang,Y.B., Chen,X.M., Luo,W.L. and Ke,Y.
    Mechanistic link between long noncoding RNA and stability of oncogene reveals stemness and chemoresistance of hepatocellular carcinoma
    World J Gastroenterol31, 103400-103400. PubMed  Europe PubMed DOI
  6. Liu,P., Chen,Z., Guo,Y., He,Q. and Pan,C.
    Recent advances in small molecule inhibitors of deubiquitinating enzymes
    Eur J Med Chem287, 117324-117324. PubMed  Europe PubMed DOI  V
  7. Mazloumi Aboukheili,A.M. and Walden,H.
    USP1 in regulation of DNA repair pathways
    DNA Repair (Amst)146, 103807-103807. PubMed  Europe PubMed DOI  V
  8. Shi,M., Shen,N., Liu,X., Yu,J., Shen,X., Chen,Y., Xia,Y. and Chen,L.
    Exosome-transmitted HSPA9 facilitates bortezomib resistance by targeting TRIP13/USP1 signaling in multiple myeloma
    Cell Commun Signal23, 152-152. PubMed  Europe PubMed DOI  I
  9. Simoneau,A., Pratt,C.B., Wu,H.J., Rajeswaran,S.S., Comer,C.G., Sudsakorn,S., Zhang,W., Liu,S., Meier,S.R., Choi,A.H., Khendu,T., Stowe,H., Shen,B., Whittington,D.A., Chen,Y., Yu,Y., Mallender,W.D., Feng,T., Andersen,J.N., Maxwell,J.P. and Throner,S.
    Characterization of TNG348: a selective, allosteric USP1 inhibitor that synergizes with PARP inhibitors in tumors with homologous recombination deficiency
    Mol Cancer Ther PubMed  Europe PubMed DOI  I
  10. Torrado,C., Ashton,N.W., D'Andrea,A.D. and Yap,T.A.
    USP1 inhibition: A journey from target discovery to clinical translation
    Pharmacol Ther271, 108865-108865. PubMed  Europe PubMed DOI  V
  11. Wu,Z., Li,C., Zhang,S., Sun,L., Hu,J., Qiu,B., Liu,S., Hong,Y., Chen,T., Wang,K., Yin,X. and Yan,J.
    High interstitial fluid pressure enhances USP1-dependent KIF11 protein stability to promote hepatocellular carcinoma progression
    J Transl Med23, 66-66. PubMed  Europe PubMed DOI
  12. Zhang,J., Liu,B., Ren,R., Song,S., Bao,X., Huan,X., Li,H., Xu,J., Yu,T., Wang,R., Miao,Z.H., Xiong,B., He,J. and Liu,T.
    Discovery and Optimization of a Series of Novel Morpholine-Containing USP1 Inhibitors
    J Med Chem68, 3673-3699. PubMed  Europe PubMed DOI  I
    13. 2024
  13. Bian,S., Ni,W., Zhou,L., Tong,Y., Dai,C., Zhao,X., Qiang,Y., Gao,J., Xiao,Y., Liu,W., Chen,C., Lin,S., Gong,J., Zhao,S., Chen,Y., Lin,Z., Liu,D., Zhao,H. and Zheng,W.
    Ubiquitin-specific protease 1 facilitates hepatocellular carcinoma progression by modulating mitochondrial fission and metabolic reprogramming via cyclin-dependent kinase 5 stabilization
    Cell Death Differ31, 1202-1218. PubMed  Europe PubMed DOI
  14. Cadzow,L., Brenneman,J., Tobin,E., Sullivan,P., Nayak,S., Ali,J.A., Shenker,S., Griffith,J., McGuire,M., Grasberger,P., Mishina,Y., Murray,M., Dodson,A.E., Gannon,H., Krall,E., Hixon,J., Chipumuro,E., Sinkevicius,K., Gokhale,P.C., Ganapathy,S., Matulonis,U.A., Liu,J.F., Olaharski,A., Sangurdekar,D., Liu,H., Wilt,J., Schlabach,M., Stegmeier,F. and Wylie,A.A.
    The USP1 Inhibitor KSQ-4279 Overcomes PARP Inhibitor Resistance in Homologous Recombination-Deficient Tumors
    Cancer Res84, 3419-3434. PubMed  Europe PubMed DOI  I
  15. Gao,W., Wang,L., Cui,W., Wang,H., Huang,G., Li,Z., Li,G. and Zhang,W.
    Deubiquitinase USP1 regulates sarbecovirus ORF6 protein function
    J Virol98, e0143723-e0143723. PubMed  Europe PubMed DOI
  16. Hu,Y., Li,X., Zhang,J., Liu,D., Lu,R. and Li,J.D.
    A genome-wide CRISPR screen identifies USP1 as a novel regulator of the mammalian circadian clock
    FEBS J291, 445-457. PubMed  Europe PubMed DOI
  17. Jayabal,P., Ma,X. and Shiio,Y.
    Roles of USP1 in Ewing sarcoma
    Genes Cancer15, 15-27. PubMed  Europe PubMed DOI
  18. Keijzer,N., Priyanka,A., Stijf-Bultsma,Y., Fish,A., Gersch,M. and Sixma,T.K.
    Variety in the USP deubiquitinase catalytic mechanism
    Life Sci Alliance7, PubMed  Europe PubMed DOI
  19. Li,N., Zhang,E., Li,Z., Lv,S., Zhao,X., Ke,Q., Zou,Q., Li,W., Wang,Y., Guo,H., Song,T. and Sun,L.
    The P53-P21-RB1 pathway promotes BRD4 degradation in liver cancer through USP1
    J Biol Chem300, 105707-105707. PubMed  Europe PubMed DOI
  20. Li,R., Wang,J., Xie,Z., Tian,X., Hou,J., Wang,D., Qian,H., Shen,H. and Xu,W.
    CircUSP1 as a novel marker promotes gastric cancer progression via stabilizing HuR to upregulate USP1 and Vimentin
    Oncogene43, 1033-1049. PubMed  Europe PubMed DOI
  21. Nespolo,A., Stefenatti,L., Pellarin,I., Gambelli,A., Rampioni Vinciguerra,G.L., Karimbayli,J., Barozzi,S., Orsenigo,F., Spizzo,R., Nicoloso,M.S., Segatto,I., D'Andrea,S., Bartoletti,M., Lucia,E., Giorda,G., Canzonieri,V., Puglisi,F., Belletti,B., Schiappacassi,M., Baldassarre,G. and Sonego,M.
    USP1 deubiquitinates PARP1 to regulate its trapping and PARylation activity
    Sci Adv10, eadp6567-eadp6567. PubMed  Europe PubMed DOI
  22. Nusawardhana,A., Pale,L.M., Nicolae,C.M. and Moldovan,G.L.
    USP1-dependent nucleolytic expansion of PRIMPOL-generated nascent DNA strand discontinuities during replication stress
    Nucleic Acids Res52, 2340-2354. PubMed  Europe PubMed DOI
  23. Rennie,M.L., Gundogdu,M., Arkinson,C., Liness,S., Frame,S. and Walden,H.
    Structural and Biochemical Insights into the Mechanism of Action of the Clinical USP1 Inhibitor, KSQ-4279
    J Med Chem67, 15557-15568. PubMed  Europe PubMed DOI  I
  24. Xiao,L., Xu,H., Li,M., Lin,L. and Zhu,Y.
    CXCR4 up-regulation mediated by USP1 deubiquitination promotes the tumorigenesis and immune escape in esophageal squamous-cell carcinoma
    J Biochem Mol Toxicol38, e70004-e70004. PubMed  Europe PubMed DOI
  25. Xue,Y., Xue,C. and Song,W.
    Emerging roles of deubiquitinating enzymes in actin cytoskeleton and tumor metastasis
    Cell Oncol (Dordr) PubMed  Europe PubMed DOI  V
  26. Yu,Z., Tong,L., Ma,C., Song,H., Wang,J., Chai,L., Wang,C., Wang,M., Wang,C., Yan,R., Fu,Y., Jia,M., Zhao,W. and Zhao,C.
    The UAF1-USP1 Deubiquitinase Complex Stabilizes cGAS and Facilitates Antiviral Responses
    J Immunol212, 295-301. PubMed  Europe PubMed DOI  I
  27. Zhai,Y., Du,Y., Yuan,H., Fan,S., Chen,X., Wang,J., He,W., Han,S., Zhang,Y., Hu,M., Zhang,G., Kong,Z. and Wan,B.
    Ubiquitin-specific proteinase 1 stabilizes PRRSV nonstructural protein Nsp1beta to promote viral replication by regulating K48 ubiquitination
    J Virol98, e0168623-e0168623. PubMed  Europe PubMed DOI  I
  28. Zhang,X., Peng,P., Bao,L.W., Zhang,A.Q., Yu,B., Li,T., Lei,J., Zhang,H.H. and Li,S.Z.
    Ubiquitin-Specific Protease 1 Promotes Bladder Cancer Progression by Stabilizing c-MYC
    Cells13, PubMed  Europe PubMed DOI
    29. 2023
  29. Antonenko,S., Zavelevich,M. and Telegeev,G.
    The role of USP1 deubiquitinase in the pathogenesis and therapy of cancer
    Acta Biochim Pol70, 219-231. PubMed  Europe PubMed DOI  V
  30. Francis,M., Bhaskar,S., Komanduri,S., Sheshadri,P., Prasanna,J. and Kumar,A.
    Deubiquitinase USP1 influences the dedifferentiation of mouse pancreatic beta-cells
    iScience26, 106771-106771. PubMed  Europe PubMed DOI
  31. Huang,P., Wang,Y., Zhang,P. and Li,Q.
    Ubiquitin-specific peptidase 1: assessing its role in cancer therapy
    Clin Exp Med23, 2953-2966. PubMed  Europe PubMed DOI  V
  32. Kim,M.S., Baek,J.H., Lee,J., Sivaraman,A., Lee,K. and Chun,K.H.
    Deubiquitinase USP1 enhances CCAAT/enhancer-binding protein beta (C/EBPbeta) stability and accelerates adipogenesis and lipid accumulation
    Cell Death Dis14, 776-776. PubMed  Europe PubMed DOI
  33. Li,L., Wang,L., Liu,D. and Zhao,Y.
    BRD7 suppresses tumor chemosensitivity to CHK1 inhibitors by inhibiting USP1-mediated deubiquitination of CHK1
    Cell Death Discov9, 313-313. PubMed  Europe PubMed DOI  K
  34. Li,X.Y., Wu,J.C., Liu,P., Li,Z.J., Wang,Y., Chen,B.Y., Hu,C.L., Fei,M.Y., Yu,P.C., Jiang,Y.L., Xu,C.H., Chang,B.H., Chen,X.C., Zong,L.J., Zhang,J.Y., Fang,Y., Sun,X.J., Xue,K., Wang,L., Chen,S.B., Jiang,S.Y., Gui,A.L., Yang,L., Gu,J.J., Yu,B.H., Zhang,Q.L. and Wang,L.
    Inhibition of USP1 reverses the chemotherapy resistance through destabilization of MAX in the relapsed/refractory B-cell lymphoma
    Leukemia37, 164-177. PubMed  Europe PubMed DOI
  35. Liu,D., Li,Q., Zang,Y., Li,X., Li,Z., Zhang,P., Feng,C., Yang,P., Cui,J., Sun,Y., Wei,T., Su,P., Zhao,X., Yang,H. and Ding,Y.
    USP1 modulates hepatocellular carcinoma progression via the Hippo/TAZ axis
    Cell Death Dis14, 264-264. PubMed  Europe PubMed DOI  K
  36. Simoneau,A., Engel,J.L., Bandi,M., Lazarides,K., Liu,S., Meier,S.R., Choi,A.H., Zhang,H., Shen,B., Martires,L., Gotur,D., Pham,T.V., Li,F., Gu,L., Gong,S., Zhang,M., Wilker,E., Pan,X., Whittington,D.A., Throner,S., Maxwell,J.P., Chen,Y., Yu,Y., Huang,A., Andersen,J.N. and Feng,T.
    Ubiquitinated PCNA Drives USP1 Synthetic Lethality in Cancer
    Mol Cancer Ther22, 215-226. PubMed  Europe PubMed DOI
  37. Zarrella,K., Longmire,P., Zeltzer,S., Collins-McMillen,D., Hancock,M., Buehler,J., Reitsma,J.M., Terhune,S.S., Nelson,J.A. and Goodrum,F.
    Human cytomegalovirus UL138 interaction with USP1 activates STAT1 in infection
    PLoS Pathog19, e1011185-e1011185. PubMed  Europe PubMed DOI
  38. Zhang,D.Y., Zhu,Y., Wu,Q., Ma,S., Ma,Y., Shen,Z.C., Wang,Z., Sun,W., Zhou,Y.C., Wang,D., Zhou,S., Liu,Z., Kwong,L.N. and Lu,Z.
    USP1 promotes cholangiocarcinoma progression by deubiquitinating PARP1 to prevent its proteasomal degradation
    Cell Death Dis14, 669-669. PubMed  Europe PubMed DOI
  39. Zhu,X., Wang,P., Zhan,X., Zhang,Y., Sheng,J., He,S., Chen,Y., Nie,D., You,X., Mai,H., Yu,Q., Li,L., Jie,L. and Hu,S.
    USP1-regulated reciprocal differentiation of Th17 cells and Treg cells by deubiquitinating and stabilizing TAZ
    Cell Mol Immunol20, 252-263. PubMed  Europe PubMed DOI  I
    40. 2022
  40. Chen,Z., Ma,Y., Guo,Z., Song,D., Chen,Z. and Sun,M.
    Ubiquitin-specific protease 1 acts as an oncogene and promotes lenvatinib efficacy in hepatocellular carcinoma by stabilizing c-kit
    Ann Hepatol27, 100669-100669. PubMed  Europe PubMed DOI
  41. Coleman,K.E., Yin,Y., Lui,S.K.L., Keegan,S., Fenyo,D., Smith,D.J., Rothenberg,E. and Huang,T.T.
    USP1-trapping lesions as a source of DNA replication stress and genomic instability
    Nat Commun13, 1740-1740. PubMed  Europe PubMed DOI
  42. Hunter,J.E., Campbell,A.E., Hannaway,N.L., Kerridge,S., Luli,S., Butterworth,J.A., Sellier,H., Mukherjee,R., Dhillon,N., Sudhindar,P.D., Shukla,R., Brownridge,P.J., Bell,H.L., Coxhead,J., Taylor,L., Leary,P., Hasoon,M.S.R., Collins,I., Garrett,M.D., Eyers,C.E. and Perkins,N.D.
    Regulation of CHK1 inhibitor resistance by a c-Rel and USP1 dependent pathway
    Biochem J479, 2063-2086. PubMed  Europe PubMed DOI
  43. Lu,Z., Zhang,Z., Yang,M. and Xiao,M.
    Ubiquitin-specific protease 1 inhibition sensitizes hepatocellular carcinoma cells to doxorubicin by ubiquitinated proliferating cell nuclear antigen-mediated attenuation of stemness
    Anticancer Drugs33, 622-631. PubMed  Europe PubMed DOI
  44. Meng,D. and Li,D.
    Ubiquitin-specific protease 1 overexpression indicates poor prognosis and promotes proliferation, migration, and invasion of gastric cancer cells
    Tissue Cell74, 101723-101723. PubMed  Europe PubMed DOI
  45. Rennie,M.L., Arkinson,C., Chaugule,V.K. and Walden,H.
    Cryo-EM reveals a mechanism of USP1 inhibition through a cryptic binding site
    Sci Adv8, eabq6353-eabq6353. PubMed  Europe PubMed DOI  I
  46. Song,B., Jiang,Y., Jiang,Y., Lin,Y. and Liu,J.
    ML323 suppresses the progression of ovarian cancer via regulating USP1-mediated cell cycle
    Front Genet13, 917481-917481. PubMed  Europe PubMed DOI  I
  47. Sun,D., Peng,Y., Ge,S. and Fu,Q.
    USP1 Inhibits NF-kappaB/NLRP3 Induced Pyroptosis through TRAF6 in Osteoblastic MC3T3-E1 Cells
    J Musculoskelet Neuronal Interact22, 536-545. PubMed  Europe PubMed
  48. Sun,Y., Sha,B., Huang,W., Li,M., Zhao,S., Zhang,Y., Yan,J., Li,Z., Tang,J., Duan,P., Shi,J., Li,P., Hu,T. and Chen,P.
    ML323, a USP1 inhibitor triggers cell cycle arrest, apoptosis and autophagy in esophageal squamous cell carcinoma cells
    Apoptosis27, 545-560. PubMed  Europe PubMed DOI  I
  49. Tu,S.L., Chen,S., Gao,S., Dong,Q.J., Wan,Z.A. and Chai,R.
    LncRNA USP1 knockdown weakens the progression of colorectal cancer via modulating UBAP2L-Smad7-TGF-beta pathway
    Comb Chem High Throughput Screen PubMed  Europe PubMed DOI  K
  50. Yuan,P., Feng,Z., Huang,H., Wang,G., Chen,Z., Xu,G., Xie,Z., Jie,Z., Zhao,X., Ma,Q., Wang,S., Shen,Y., Huang,Y., Han,Y., Ye,H., Wang,J., Shi,P. and Sun,X.
    USP1 inhibition suppresses the progression of osteosarcoma via destabilizing TAZ
    Int J Biol Sci18, 3122-3136. PubMed  Europe PubMed DOI  I
    51. 2021
  51. Du,Z., Wu,T., Liu,L., Luo,B. and Wei,C.
    Ubiquitin specific peptidase 1 promotes hepatic fibrosis through positive regulation of CXCL1 by deubiquitinating SNAIL
    Dig Liver Dis PubMed  Europe PubMed DOI
  52. Gong,H., Liu,L., Cui,L., Ma,H. and Shen,L.
    ALKBH5-mediated m6A-demethylation of USP1 regulated T-cell acute lymphoblastic leukemia cell glucocorticoid resistance by Aurora B
    Mol Carcinog PubMed  Europe PubMed DOI
  53. Jang,S.W. and Kim,J.M.
    Mutation of aspartic acid 199 in USP1 disrupts its deubiquitinating activity and impairs DNA repair
    FEBS Lett PubMed  Europe PubMed DOI
  54. Kuang,X., Xiong,J., Lu,T., Wang,W., Zhang,Z. and Wang,J.
    Inhibition of USP1 induces apoptosis via ID1/AKT pathway in B-cell acute lymphoblastic leukemia cells
    Int J Med Sci18, 245-255. PubMed  Europe PubMed DOI  K  I
  55. Lemonidis,K., Arkinson,C., Rennie,M.L. and Walden,H.
    Mechanism, specificity, and function of FANCD2-FANCI ubiquitination and deubiquitination
    FEBS J PubMed  Europe PubMed DOI  V
  56. Liao,Y., Shao,Z., Liu,Y., Xia,X., Deng,Y., Yu,C., Sun,W., Kong,W., He,X., Liu,F., Guo,Z., Chen,G., Tang,D., Gan,H., Liu,J. and Huang,H.
    USP1-dependent RPS16 protein stability drives growth and metastasis of human hepatocellular carcinoma cells
    J Exp Clin Cancer Res40, 201-201. PubMed  Europe PubMed DOI
  57. Omilusik,K.D., Nadjsombati,M.S., Yoshida,T.M., Shaw,L.A., Goulding,J. and Goldrath,A.W.
    Ubiquitin Specific Protease 1 Expression and Function in T Cell Immunity
    J Immunol207, 1377-1387. PubMed  Europe PubMed DOI
  58. Rennie,M.L., Arkinson,C., Chaugule,V.K., Toth,R. and Walden,H.
    Structural basis of FANCD2 deubiquitination by USP1-UAF1
    Nat Struct Mol Biol28, 356-364. PubMed  Europe PubMed DOI
    59. 2020
  59. Antonenko,S.V. and Telegeev,G.D.
    Inhibition of USP1, a new partner of Bcr-Abl, results in decrease of Bcr-Abl level in K562 cells
    Exp Oncol42, 109-114. PubMed  Europe PubMed DOI
  60. Cui,S.Z., Lei,Z.Y., Guan,T.P., Fan,L.L., Li,Y.Q., Geng,X.Y., Fu,D.X., Jiang,H.W. and Xu,S.H.
    Targeting USP1-dependent KDM4A protein stability as a potential prostate cancer therapy
    Cancer Sci111, 1567-1581. PubMed  Europe PubMed DOI
  61. Goldbraikh,D., Neufeld,D., Eid-Mutlak,Y., Lasry,I., Gilda,J.E., Parnis,A. and Cohen,S.
    USP1 deubiquitinates Akt to inhibit PI3K-Akt-FoxO signaling in muscle during prolonged starvation
    EMBO Repe48791-e48791. PubMed  Europe PubMed DOI
  62. Li,Y., Xu,Y., Gao,C., Sun,Y., Zhou,K., Wang,P., Cheng,J., Guo,W., Ya,C., Fan,J. and Yang,X.
    USP1 Maintains the Survival of Liver Circulating Tumor Cells by Deubiquitinating and Stabilizing TBLR1
    Front Oncol10, 554809-554809. PubMed  Europe PubMed DOI
  63. Niu,Z., Li,X., Feng,S., Huang,Q., Zhuang,T., Yan,C., Qian,H., Ding,Y., Zhu,J. and Xu,W.
    The deubiquitinating enzyme USP1 modulates ERalpha and modulates breast cancer progression
    J Cancer11, 6992-7000. PubMed  Europe PubMed DOI  K
  64. Zhao,Y., Xue,C., Xie,Z., Ouyang,X. and Li,L.
    Comprehensive analysis of ubiquitin-specific protease 1 reveals its importance in hepatocellular carcinoma
    Cell Prolif53, e12908-e12908. PubMed  Europe PubMed DOI  K
    65. 2019
  65. Ma,A., Tang,M., Zhang,L., Wang,B., Yang,Z., Liu,Y., Xu,G., Wu,L., Jing,T., Xu,X., Yang,S. and Liu,Y.
    USP1 inhibition destabilizes KPNA2 and suppresses breast cancer metastasis
    Oncogene38, 2405-2419. PubMed  Europe PubMed DOI  I
  66. Raimondi,M., Cesselli,D., Di Loreto,C., La Marra,F., Schneider,C. and Demarchi,F.
    USP1 (ubiquitin specific peptidase 1) targets ULK1 and regulates its cellular compartmentalization and autophagy
    Autophagy15, 613-630. PubMed  Europe PubMed DOI
  67. Xu,X., Li,S., Cui,X., Han,K., Wang,J., Hou,X., Cui,L., He,S., Xiao,J. and Yang,Y.
    Inhibition of ubiquitin specific protease 1 sensitizes colorectal cancer cells to DNA-damaging chemotherapeutics
    Front Oncol9, 1406-1406. PubMed  Europe PubMed DOI  I
    68. 2018
  68. Arkinson,C., Chaugule,V.K., Toth,R. and Walden,H.
    Specificity for deubiquitination of monoubiquitinated FANCD2 is driven by the N-terminus of USP1
    Life Sci Alliance1, e201800162-e201800162. PubMed  Europe PubMed DOI
    69. 2017
  69. Das,D.S., Das,A., Ray,A., Song,Y., Samur,M.K., Munshi,N.C., Chauhan,D. and Anderson,K.C.
    Blockade of deubiquitylating enzyme USP1 inhibits DNA repair and triggers apoptosis in multiple myeloma cells
    Clin Cancer Res23, 4280-4289. PubMed  Europe PubMed DOI  I
  70. Yu,Z., Song,H., Jia,M., Zhang,J., Wang,W., Li,Q., Zhang,L. and Zhao,W.
    USP1-UAF1 deubiquitinase complex stabilizes TBK1 and enhances antiviral responses
    J Exp Med214, 3553-3563. PubMed  Europe PubMed DOI
  71. Zheng,H., Wang,M., Zhao,C., Wu,S., Yu,P., Lu,Y., Wang,T. and Ai,Y.
    Characterization of the deubiquitination activity and substrate specificity of the chicken ubiquitin-specific protease 1/USP associated factor 1 complex
    PLoS ONE12, e0186535-e0186535. PubMed  Europe PubMed DOI
    72. 2016
  72. Jung,J.K., Jang,S.W. and Kim,J.M.
    A novel role for the deubiquitinase USP1 in the control of centrosome duplication
    Cell Cycle15, 584-592. PubMed  Europe PubMed DOI
  73. Kim,M. and Kim,J.M.
    The role of USP1 autocleavage in DNA interstrand crosslink repair
    FEBS Lett590, 340-348. PubMed  Europe PubMed DOI
  74. Lee,J.K., Chang,N., Yoon,Y., Yang,H., Cho,H., Kim,E., Shin,Y., Kang,W., Oh,Y.T., Mun,G.I., Joo,K.M., Nam,D.H. and Lee,J.
    USP1 targeting impedes GBM growth by inhibiting stem cell maintenance and radioresistance
    Neuro Oncol18, 37-47. PubMed  Europe PubMed DOI  K  I
  75. Liu,J., Zhu,H., Zhong,N., Jiang,Z., Xu,L., Deng,Y., Jiang,Z., Wang,H. and Wang,J.
    Gene silencing of USP1 by lentivirus effectively inhibits proliferation and invasion of human osteosarcoma cells
    Int J Oncol49, 2549-2557. PubMed  Europe PubMed DOI  K  T
  76. Ogrunc,M., Martinez-Zamudio,R.I., Sadoun,P.B., Dore,G., Schwerer,H., Pasero,P., Lemaitre,J.M., Dejean,A. and Bischof,O.
    USP1 regulates cellular senescence by controlling genomic integrity
    Cell Rep15, 1401-1411. PubMed  Europe PubMed DOI  T
  77. Olazabal-Herrero,A., Garcia-Santisteban,I. and Rodriguez,J.A.
    Mutations in the 'Fingers' subdomain of the deubiquitinase USP1 modulate its function and activity
    FEBS J283, 929-946. PubMed  Europe PubMed DOI  M  I
  78. Rahme,G.J., Zhang,Z., Young,A.L., Cheng,C., Bivona,E.J., Fiering,S.N., Hitoshi,Y. and Israel,M.A.
    PDGF Engages an E2F-USP1 signaling pathway to support ID2-mediated survival of proneural glioma cells
    Cancer Res76, 2964-2976. PubMed  Europe PubMed DOI
  79. Sourisseau,T., Helissey,C., Lefebvre,C., Ponsonnailles,F., Malka-Mahieu,H., Olaussen,K.A., Andre,F., Vagner,S. and Soria,J.C.
    Translational regulation of the mRNA encoding the ubiquitin peptidase USP1 involved in the DNA damage response as a determinant of Cisplatin resistance
    Cell Cycle15, 295-302. PubMed  Europe PubMed DOI
    80. 2015
  80. Olazabal-Herrero,A., Garcia-Santisteban,I. and Rodriguez,J.
    Structure-function analysis of USP1: insights into the role of Ser313 phosphorylation site and the effect of cancer-associated mutations on autocleavage
    Mol Cancer14, 33-33. PubMed  Europe PubMed DOI
    81. 2014
  81. Liang,Q., Dexheimer,T.S., Zhang,P., Rosenthal,A.S., Villamil,M.A., You,C., Zhang,Q., Chen,J., Ott,C.A., Sun,H., Luci,D.K., Yuan,B., Simeonov,A., Jadhav,A., Xiao,H., Wang,Y., Maloney,D.J. and Zhuang,Z.
    A selective USP1-UAF1 inhibitor links deubiquitination to DNA damage responses
    Nat Chem Biol10, 298-304. PubMed  Europe PubMed DOI  I
    82. 2013
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