Literature for peptidase C19.019: ubiquitin-specific peptidase 1

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Literature Substrates

(Topics flags: M Mutation, T Target, I Inhibitor, K Knockout, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

2025

Gui,A., Yan,Y., Jiang,S., Chen,F., Zhou,X., Sun,Q., Qiu,S., Wu,J., Li,X., Zhang,J., Liu,J., Zhu,S., Wang,L., Liu,W., Zuo,J., Zhang,Q. and Yang,L. USP1-TRAF2 axis-regulated mortalin stability mediates chemoresistance by disrupting calcium transport in peripheral T-cell lymphoma Proc Natl Acad Sci U S A (2025) 122, e2504195122-e2504195122. PubMed Europe PubMed DOI PMC EPMC
Han,D., Wang,L., Jiang,S., Su,P., Chen,B., Zhao,W., Chen,T., Zhang,N., Wang,X., Liang,Y., Li,Y., Li,C., Chen,X., Luo,D. and Yang,Q. The USP1-WDR48 deubiquitinase complex functions as a molecular switch regulating tumor-associated macrophage activation and anti-tumor response Cell Death Differ (2025) PubMed Europe PubMed DOI
Hu,X., Wu,Y., Yao,M., Chen,Z. and Li,Q. The other side of the coin: protein deubiquitination by Ubiquitin-Specific Protease 1 in cancer progression and therapy Future Med Chem (2025) , 1-17. PubMed Europe PubMed DOI V
Hui,Y.B. and Shang,G.N. NRF1 Transcriptionally Regulates USP1-Mediated Deubiquitination of AURKA to Facilitate Osteosarcoma Progression Mol Biotechnol (2025) PubMed Europe PubMed DOI K
Jiang,S., Tang,Y., Ma,F., Niu,Y. and Sun,L. Ubiquitin-specific protease 1 facilitates tumor immune escape from natural killer cells and predicts the prognosis in small cell lung cancer Oncol Res (2025) 33, 213-224. PubMed Europe PubMed DOI PMC EPMC
Keijzer,N., Sakoltchik,J., Majumder,K., van Lil,N., El Oualid,F., Fish,A. and Sixma,T.K. USP1/UAF1 targets polyubiquitinated PCNA with an exo-cleavage mechanism that can temporarily enrich for monoubiquitinated PCNA Nat Commun (2025) 16, 6991-6991. PubMed Europe PubMed DOI PMC EPMC
Li,L., Fan,Z., Liu,M., Dong,H., Li,J., Li,Y., Song,Z., Liu,Y., Zhang,Z., Gu,X. and Zhang,T. USP1 promotes pancreatic cancer progression and autophagy by deubiquitinating ATG14 J Biol Chem (2025) , 108190-108190. PubMed Europe PubMed DOI K
Liang,Y.B., Chen,X.M., Luo,W.L. and Ke,Y. Mechanistic link between long noncoding RNA and stability of oncogene reveals stemness and chemoresistance of hepatocellular carcinoma World J Gastroenterol (2025) 31, 103400-103400. PubMed Europe PubMed DOI PMC EPMC
Ling,H., Xiao,S., Lei,Y., Zhou,Y., Tan,J., Chen,X., Ma,D., Liang,C., Liu,Q., Liu,W. and Zeng,T. The advancement of ubiquitination regulation in apoptosis, ferroptosis, autophagy, drug resistance and treatment of cancer Arch Biochem Biophys (2025) 771, 110497-110497. PubMed Europe PubMed DOI V
Liu,P., Chen,Z., Guo,Y., He,Q. and Pan,C. Recent advances in small molecule inhibitors of deubiquitinating enzymes Eur J Med Chem (2025) 287, 117324-117324. PubMed Europe PubMed DOI V
Mazloumi Aboukheili,A.M. and Walden,H. USP1 in regulation of DNA repair pathways DNA Repair (Amst) (2025) 146, 103807-103807. PubMed Europe PubMed DOI V
Shi,M., Shen,N., Liu,X., Yu,J., Shen,X., Chen,Y., Xia,Y. and Chen,L. Exosome-transmitted HSPA9 facilitates bortezomib resistance by targeting TRIP13/USP1 signaling in multiple myeloma Cell Commun Signal (2025) 23, 152-152. PubMed Europe PubMed DOI PMC EPMC I
Simoneau,A., Pratt,C.B., Wu,H.J., Rajeswaran,S.S., Comer,C.G., Sudsakorn,S., Zhang,W., Liu,S., Meier,S.R., Choi,A.H., Khendu,T., Stowe,H., Shen,B., Whittington,D.A., Chen,Y., Yu,Y., Mallender,W.D., Feng,T., Andersen,J.N., Maxwell,J.P. and Throner,S. Characterization of TNG348: a selective, allosteric USP1 inhibitor that synergizes with PARP inhibitors in tumors with homologous recombination deficiency Mol Cancer Ther (2025) PubMed Europe PubMed DOI I
Torrado,C., Ashton,N.W., D'Andrea,A.D. and Yap,T.A. USP1 inhibition: A journey from target discovery to clinical translation Pharmacol Ther (2025) 271, 108865-108865. PubMed Europe PubMed DOI V
Wu,Z., Li,C., Zhang,S., Sun,L., Hu,J., Qiu,B., Liu,S., Hong,Y., Chen,T., Wang,K., Yin,X. and Yan,J. High interstitial fluid pressure enhances USP1-dependent KIF11 protein stability to promote hepatocellular carcinoma progression J Transl Med (2025) 23, 66-66. PubMed Europe PubMed DOI PMC EPMC
Zhang,J., Liu,B., Ren,R., Song,S., Bao,X., Huan,X., Li,H., Xu,J., Yu,T., Wang,R., Miao,Z.H., Xiong,B., He,J. and Liu,T. Discovery and Optimization of a Series of Novel Morpholine-Containing USP1 Inhibitors J Med Chem (2025) 68, 3673-3699. PubMed Europe PubMed DOI I

2024

Bian,S., Ni,W., Zhou,L., Tong,Y., Dai,C., Zhao,X., Qiang,Y., Gao,J., Xiao,Y., Liu,W., Chen,C., Lin,S., Gong,J., Zhao,S., Chen,Y., Lin,Z., Liu,D., Zhao,H. and Zheng,W. Ubiquitin-specific protease 1 facilitates hepatocellular carcinoma progression by modulating mitochondrial fission and metabolic reprogramming via cyclin-dependent kinase 5 stabilization Cell Death Differ (2024) 31, 1202-1218. PubMed Europe PubMed DOI
Cadzow,L., Brenneman,J., Tobin,E., Sullivan,P., Nayak,S., Ali,J.A., Shenker,S., Griffith,J., McGuire,M., Grasberger,P., Mishina,Y., Murray,M., Dodson,A.E., Gannon,H., Krall,E., Hixon,J., Chipumuro,E., Sinkevicius,K., Gokhale,P.C., Ganapathy,S., Matulonis,U.A., Liu,J.F., Olaharski,A., Sangurdekar,D., Liu,H., Wilt,J., Schlabach,M., Stegmeier,F. and Wylie,A.A. The USP1 Inhibitor KSQ-4279 Overcomes PARP Inhibitor Resistance in Homologous Recombination-Deficient Tumors Cancer Res (2024) 84, 3419-3434. PubMed Europe PubMed DOI PMC EPMC I
Gao,W., Wang,L., Cui,W., Wang,H., Huang,G., Li,Z., Li,G. and Zhang,W. Deubiquitinase USP1 regulates sarbecovirus ORF6 protein function J Virol (2024) 98, e0143723-e0143723. PubMed Europe PubMed DOI PMC EPMC
Hu,Y., Li,X., Zhang,J., Liu,D., Lu,R. and Li,J.D. A genome-wide CRISPR screen identifies USP1 as a novel regulator of the mammalian circadian clock FEBS J (2024) 291, 445-457. PubMed Europe PubMed DOI
Jayabal,P., Ma,X. and Shiio,Y. Roles of USP1 in Ewing sarcoma Genes Cancer (2024) 15, 15-27. PubMed Europe PubMed DOI PMC EPMC
Keijzer,N., Priyanka,A., Stijf-Bultsma,Y., Fish,A., Gersch,M. and Sixma,T.K. Variety in the USP deubiquitinase catalytic mechanism Life Sci Alliance (2024) 7 PubMed Europe PubMed DOI PMC EPMC
Li,N., Zhang,E., Li,Z., Lv,S., Zhao,X., Ke,Q., Zou,Q., Li,W., Wang,Y., Guo,H., Song,T. and Sun,L. The P53-P21-RB1 pathway promotes BRD4 degradation in liver cancer through USP1 J Biol Chem (2024) 300, 105707-105707. PubMed Europe PubMed DOI PMC EPMC
Li,R., Wang,J., Xie,Z., Tian,X., Hou,J., Wang,D., Qian,H., Shen,H. and Xu,W. CircUSP1 as a novel marker promotes gastric cancer progression via stabilizing HuR to upregulate USP1 and Vimentin Oncogene (2024) 43, 1033-1049. PubMed Europe PubMed DOI PMC EPMC
Nespolo,A., Stefenatti,L., Pellarin,I., Gambelli,A., Rampioni Vinciguerra,G.L., Karimbayli,J., Barozzi,S., Orsenigo,F., Spizzo,R., Nicoloso,M.S., Segatto,I., D'Andrea,S., Bartoletti,M., Lucia,E., Giorda,G., Canzonieri,V., Puglisi,F., Belletti,B., Schiappacassi,M., Baldassarre,G. and Sonego,M. USP1 deubiquitinates PARP1 to regulate its trapping and PARylation activity Sci Adv (2024) 10, eadp6567-eadp6567. PubMed Europe PubMed DOI PMC EPMC
Nusawardhana,A., Pale,L.M., Nicolae,C.M. and Moldovan,G.L. USP1-dependent nucleolytic expansion of PRIMPOL-generated nascent DNA strand discontinuities during replication stress Nucleic Acids Res (2024) 52, 2340-2354. PubMed Europe PubMed DOI PMC EPMC
Rennie,M.L., Gundogdu,M., Arkinson,C., Liness,S., Frame,S. and Walden,H. Structural and Biochemical Insights into the Mechanism of Action of the Clinical USP1 Inhibitor, KSQ-4279 J Med Chem (2024) 67, 15557-15568. PubMed Europe PubMed DOI I
Xiao,L., Xu,H., Li,M., Lin,L. and Zhu,Y. CXCR4 up-regulation mediated by USP1 deubiquitination promotes the tumorigenesis and immune escape in esophageal squamous-cell carcinoma J Biochem Mol Toxicol (2024) 38, e70004-e70004. PubMed Europe PubMed DOI
Xue,Y., Xue,C. and Song,W. Emerging roles of deubiquitinating enzymes in actin cytoskeleton and tumor metastasis Cell Oncol (Dordr) (2024) PubMed Europe PubMed DOI V
Yu,Z., Tong,L., Ma,C., Song,H., Wang,J., Chai,L., Wang,C., Wang,M., Wang,C., Yan,R., Fu,Y., Jia,M., Zhao,W. and Zhao,C. The UAF1-USP1 Deubiquitinase Complex Stabilizes cGAS and Facilitates Antiviral Responses J Immunol (2024) 212, 295-301. PubMed Europe PubMed DOI I
Zhai,Y., Du,Y., Yuan,H., Fan,S., Chen,X., Wang,J., He,W., Han,S., Zhang,Y., Hu,M., Zhang,G., Kong,Z. and Wan,B. Ubiquitin-specific proteinase 1 stabilizes PRRSV nonstructural protein Nsp1beta to promote viral replication by regulating K48 ubiquitination J Virol (2024) 98, e0168623-e0168623. PubMed Europe PubMed DOI PMC EPMC I
Zhang,X., Peng,P., Bao,L.W., Zhang,A.Q., Yu,B., Li,T., Lei,J., Zhang,H.H. and Li,S.Z. Ubiquitin-Specific Protease 1 Promotes Bladder Cancer Progression by Stabilizing c-MYC Cells (2024) 13 PubMed Europe PubMed DOI PMC EPMC

2023

Antonenko,S., Zavelevich,M. and Telegeev,G. The role of USP1 deubiquitinase in the pathogenesis and therapy of cancer Acta Biochim Pol (2023) 70, 219-231. PubMed Europe PubMed DOI V
Francis,M., Bhaskar,S., Komanduri,S., Sheshadri,P., Prasanna,J. and Kumar,A. Deubiquitinase USP1 influences the dedifferentiation of mouse pancreatic beta-cells iScience (2023) 26, 106771-106771. PubMed Europe PubMed DOI PMC EPMC
Huang,P., Wang,Y., Zhang,P. and Li,Q. Ubiquitin-specific peptidase 1: assessing its role in cancer therapy Clin Exp Med (2023) 23, 2953-2966. PubMed Europe PubMed DOI V
Kim,M.S., Baek,J.H., Lee,J., Sivaraman,A., Lee,K. and Chun,K.H. Deubiquitinase USP1 enhances CCAAT/enhancer-binding protein beta (C/EBPbeta) stability and accelerates adipogenesis and lipid accumulation Cell Death Dis (2023) 14, 776-776. PubMed Europe PubMed DOI PMC EPMC
Li,L., Wang,L., Liu,D. and Zhao,Y. BRD7 suppresses tumor chemosensitivity to CHK1 inhibitors by inhibiting USP1-mediated deubiquitination of CHK1 Cell Death Discov (2023) 9, 313-313. PubMed Europe PubMed DOI PMC EPMC K
Li,X.Y., Wu,J.C., Liu,P., Li,Z.J., Wang,Y., Chen,B.Y., Hu,C.L., Fei,M.Y., Yu,P.C., Jiang,Y.L., Xu,C.H., Chang,B.H., Chen,X.C., Zong,L.J., Zhang,J.Y., Fang,Y., Sun,X.J., Xue,K., Wang,L., Chen,S.B., Jiang,S.Y., Gui,A.L., Yang,L., Gu,J.J., Yu,B.H., Zhang,Q.L. and Wang,L. Inhibition of USP1 reverses the chemotherapy resistance through destabilization of MAX in the relapsed/refractory B-cell lymphoma Leukemia (2023) 37, 164-177. PubMed Europe PubMed DOI PMC EPMC
Liu,D., Li,Q., Zang,Y., Li,X., Li,Z., Zhang,P., Feng,C., Yang,P., Cui,J., Sun,Y., Wei,T., Su,P., Zhao,X., Yang,H. and Ding,Y. USP1 modulates hepatocellular carcinoma progression via the Hippo/TAZ axis Cell Death Dis (2023) 14, 264-264. PubMed Europe PubMed DOI PMC EPMC K
Simoneau,A., Engel,J.L., Bandi,M., Lazarides,K., Liu,S., Meier,S.R., Choi,A.H., Zhang,H., Shen,B., Martires,L., Gotur,D., Pham,T.V., Li,F., Gu,L., Gong,S., Zhang,M., Wilker,E., Pan,X., Whittington,D.A., Throner,S., Maxwell,J.P., Chen,Y., Yu,Y., Huang,A., Andersen,J.N. and Feng,T. Ubiquitinated PCNA Drives USP1 Synthetic Lethality in Cancer Mol Cancer Ther (2023) 22, 215-226. PubMed Europe PubMed DOI PMC EPMC
Zarrella,K., Longmire,P., Zeltzer,S., Collins-McMillen,D., Hancock,M., Buehler,J., Reitsma,J.M., Terhune,S.S., Nelson,J.A. and Goodrum,F. Human cytomegalovirus UL138 interaction with USP1 activates STAT1 in infection PLoS Pathog (2023) 19, e1011185-e1011185. PubMed Europe PubMed DOI PMC EPMC
Zhang,D.Y., Zhu,Y., Wu,Q., Ma,S., Ma,Y., Shen,Z.C., Wang,Z., Sun,W., Zhou,Y.C., Wang,D., Zhou,S., Liu,Z., Kwong,L.N. and Lu,Z. USP1 promotes cholangiocarcinoma progression by deubiquitinating PARP1 to prevent its proteasomal degradation Cell Death Dis (2023) 14, 669-669. PubMed Europe PubMed DOI PMC EPMC
Zhu,X., Wang,P., Zhan,X., Zhang,Y., Sheng,J., He,S., Chen,Y., Nie,D., You,X., Mai,H., Yu,Q., Li,L., Jie,L. and Hu,S. USP1-regulated reciprocal differentiation of Th17 cells and Treg cells by deubiquitinating and stabilizing TAZ Cell Mol Immunol (2023) 20, 252-263. PubMed Europe PubMed DOI PMC EPMC I

2022

Chen,Z., Ma,Y., Guo,Z., Song,D., Chen,Z. and Sun,M. Ubiquitin-specific protease 1 acts as an oncogene and promotes lenvatinib efficacy in hepatocellular carcinoma by stabilizing c-kit Ann Hepatol (2022) 27, 100669-100669. PubMed Europe PubMed DOI
Coleman,K.E., Yin,Y., Lui,S.K.L., Keegan,S., Fenyo,D., Smith,D.J., Rothenberg,E. and Huang,T.T. USP1-trapping lesions as a source of DNA replication stress and genomic instability Nat Commun (2022) 13, 1740-1740. PubMed Europe PubMed DOI PMC EPMC
Hunter,J.E., Campbell,A.E., Hannaway,N.L., Kerridge,S., Luli,S., Butterworth,J.A., Sellier,H., Mukherjee,R., Dhillon,N., Sudhindar,P.D., Shukla,R., Brownridge,P.J., Bell,H.L., Coxhead,J., Taylor,L., Leary,P., Hasoon,M.S.R., Collins,I., Garrett,M.D., Eyers,C.E. and Perkins,N.D. Regulation of CHK1 inhibitor resistance by a c-Rel and USP1 dependent pathway Biochem J (2022) 479, 2063-2086. PubMed Europe PubMed DOI PMC EPMC
Lu,Z., Zhang,Z., Yang,M. and Xiao,M. Ubiquitin-specific protease 1 inhibition sensitizes hepatocellular carcinoma cells to doxorubicin by ubiquitinated proliferating cell nuclear antigen-mediated attenuation of stemness Anticancer Drugs (2022) 33, 622-631. PubMed Europe PubMed DOI
Meng,D. and Li,D. Ubiquitin-specific protease 1 overexpression indicates poor prognosis and promotes proliferation, migration, and invasion of gastric cancer cells Tissue Cell (2022) 74, 101723-101723. PubMed Europe PubMed DOI
Rennie,M.L., Arkinson,C., Chaugule,V.K. and Walden,H. Cryo-EM reveals a mechanism of USP1 inhibition through a cryptic binding site Sci Adv (2022) 8, eabq6353-eabq6353. PubMed Europe PubMed DOI PMC EPMC I
Song,B., Jiang,Y., Jiang,Y., Lin,Y. and Liu,J. ML323 suppresses the progression of ovarian cancer via regulating USP1-mediated cell cycle Front Genet (2022) 13, 917481-917481. PubMed Europe PubMed DOI PMC EPMC I
Sun,D., Peng,Y., Ge,S. and Fu,Q. USP1 Inhibits NF-kappaB/NLRP3 Induced Pyroptosis through TRAF6 in Osteoblastic MC3T3-E1 Cells J Musculoskelet Neuronal Interact (2022) 22, 536-545. PubMed Europe PubMed PMC EPMC
Sun,Y., Sha,B., Huang,W., Li,M., Zhao,S., Zhang,Y., Yan,J., Li,Z., Tang,J., Duan,P., Shi,J., Li,P., Hu,T. and Chen,P. ML323, a USP1 inhibitor triggers cell cycle arrest, apoptosis and autophagy in esophageal squamous cell carcinoma cells Apoptosis (2022) 27, 545-560. PubMed Europe PubMed DOI I
Tu,S.L., Chen,S., Gao,S., Dong,Q.J., Wan,Z.A. and Chai,R. LncRNA USP1 knockdown weakens the progression of colorectal cancer via modulating UBAP2L-Smad7-TGF-beta pathway Comb Chem High Throughput Screen (2022) PubMed Europe PubMed DOI K
Yuan,P., Feng,Z., Huang,H., Wang,G., Chen,Z., Xu,G., Xie,Z., Jie,Z., Zhao,X., Ma,Q., Wang,S., Shen,Y., Huang,Y., Han,Y., Ye,H., Wang,J., Shi,P. and Sun,X. USP1 inhibition suppresses the progression of osteosarcoma via destabilizing TAZ Int J Biol Sci (2022) 18, 3122-3136. PubMed Europe PubMed DOI PMC EPMC I

2021

Du,Z., Wu,T., Liu,L., Luo,B. and Wei,C. Ubiquitin specific peptidase 1 promotes hepatic fibrosis through positive regulation of CXCL1 by deubiquitinating SNAIL Dig Liver Dis (2021) PubMed Europe PubMed DOI
Gong,H., Liu,L., Cui,L., Ma,H. and Shen,L. ALKBH5-mediated m6A-demethylation of USP1 regulated T-cell acute lymphoblastic leukemia cell glucocorticoid resistance by Aurora B Mol Carcinog (2021) PubMed Europe PubMed DOI
Jang,S.W. and Kim,J.M. Mutation of aspartic acid 199 in USP1 disrupts its deubiquitinating activity and impairs DNA repair FEBS Lett (2021) PubMed Europe PubMed DOI
Kuang,X., Xiong,J., Lu,T., Wang,W., Zhang,Z. and Wang,J. Inhibition of USP1 induces apoptosis via ID1/AKT pathway in B-cell acute lymphoblastic leukemia cells Int J Med Sci (2021) 18, 245-255. PubMed Europe PubMed DOI PMC EPMC K I
Lemonidis,K., Arkinson,C., Rennie,M.L. and Walden,H. Mechanism, specificity, and function of FANCD2-FANCI ubiquitination and deubiquitination FEBS J (2021) PubMed Europe PubMed DOI V
Liao,Y., Shao,Z., Liu,Y., Xia,X., Deng,Y., Yu,C., Sun,W., Kong,W., He,X., Liu,F., Guo,Z., Chen,G., Tang,D., Gan,H., Liu,J. and Huang,H. USP1-dependent RPS16 protein stability drives growth and metastasis of human hepatocellular carcinoma cells J Exp Clin Cancer Res (2021) 40, 201-201. PubMed Europe PubMed DOI PMC EPMC
Omilusik,K.D., Nadjsombati,M.S., Yoshida,T.M., Shaw,L.A., Goulding,J. and Goldrath,A.W. Ubiquitin Specific Protease 1 Expression and Function in T Cell Immunity J Immunol (2021) 207, 1377-1387. PubMed Europe PubMed DOI PMC EPMC
Rennie,M.L., Arkinson,C., Chaugule,V.K., Toth,R. and Walden,H. Structural basis of FANCD2 deubiquitination by USP1-UAF1 Nat Struct Mol Biol (2021) 28, 356-364. PubMed Europe PubMed DOI

2020

Antonenko,S.V. and Telegeev,G.D. Inhibition of USP1, a new partner of Bcr-Abl, results in decrease of Bcr-Abl level in K562 cells Exp Oncol (2020) 42, 109-114. PubMed Europe PubMed DOI
Cui,S.Z., Lei,Z.Y., Guan,T.P., Fan,L.L., Li,Y.Q., Geng,X.Y., Fu,D.X., Jiang,H.W. and Xu,S.H. Targeting USP1-dependent KDM4A protein stability as a potential prostate cancer therapy Cancer Sci (2020) 111, 1567-1581. PubMed Europe PubMed DOI
Goldbraikh,D., Neufeld,D., Eid-Mutlak,Y., Lasry,I., Gilda,J.E., Parnis,A. and Cohen,S. USP1 deubiquitinates Akt to inhibit PI3K-Akt-FoxO signaling in muscle during prolonged starvation EMBO Rep (2020) , e48791-e48791. PubMed Europe PubMed DOI
Li,Y., Xu,Y., Gao,C., Sun,Y., Zhou,K., Wang,P., Cheng,J., Guo,W., Ya,C., Fan,J. and Yang,X. USP1 Maintains the Survival of Liver Circulating Tumor Cells by Deubiquitinating and Stabilizing TBLR1 Front Oncol (2020) 10, 554809-554809. PubMed Europe PubMed DOI PMC EPMC
Niu,Z., Li,X., Feng,S., Huang,Q., Zhuang,T., Yan,C., Qian,H., Ding,Y., Zhu,J. and Xu,W. The deubiquitinating enzyme USP1 modulates ERalpha and modulates breast cancer progression J Cancer (2020) 11, 6992-7000. PubMed Europe PubMed DOI PMC EPMC K
Zhao,Y., Xue,C., Xie,Z., Ouyang,X. and Li,L. Comprehensive analysis of ubiquitin-specific protease 1 reveals its importance in hepatocellular carcinoma Cell Prolif (2020) 53, e12908-e12908. PubMed Europe PubMed DOI PMC EPMC K

2019

Ma,A., Tang,M., Zhang,L., Wang,B., Yang,Z., Liu,Y., Xu,G., Wu,L., Jing,T., Xu,X., Yang,S. and Liu,Y. USP1 inhibition destabilizes KPNA2 and suppresses breast cancer metastasis Oncogene (2019) 38, 2405-2419. PubMed Europe PubMed DOI I
Raimondi,M., Cesselli,D., Di Loreto,C., La Marra,F., Schneider,C. and Demarchi,F. USP1 (ubiquitin specific peptidase 1) targets ULK1 and regulates its cellular compartmentalization and autophagy Autophagy (2019) 15, 613-630. PubMed Europe PubMed DOI
Xu,X., Li,S., Cui,X., Han,K., Wang,J., Hou,X., Cui,L., He,S., Xiao,J. and Yang,Y. Inhibition of ubiquitin specific protease 1 sensitizes colorectal cancer cells to DNA-damaging chemotherapeutics Front Oncol (2019) 9, 1406-1406. PubMed Europe PubMed DOI PMC EPMC I

2018

Arkinson,C., Chaugule,V.K., Toth,R. and Walden,H. Specificity for deubiquitination of monoubiquitinated FANCD2 is driven by the N-terminus of USP1 Life Sci Alliance (2018) 1, e201800162-e201800162. PubMed Europe PubMed DOI PMC EPMC

2017

Das,D.S., Das,A., Ray,A., Song,Y., Samur,M.K., Munshi,N.C., Chauhan,D. and Anderson,K.C. Blockade of deubiquitylating enzyme USP1 inhibits DNA repair and triggers apoptosis in multiple myeloma cells Clin Cancer Res (2017) 23, 4280-4289. PubMed Europe PubMed DOI I
Yu,Z., Song,H., Jia,M., Zhang,J., Wang,W., Li,Q., Zhang,L. and Zhao,W. USP1-UAF1 deubiquitinase complex stabilizes TBK1 and enhances antiviral responses J Exp Med (2017) 214, 3553-3563. PubMed Europe PubMed DOI
Zheng,H., Wang,M., Zhao,C., Wu,S., Yu,P., Lu,Y., Wang,T. and Ai,Y. Characterization of the deubiquitination activity and substrate specificity of the chicken ubiquitin-specific protease 1/USP associated factor 1 complex PLoS ONE (2017) 12, e0186535-e0186535. PubMed Europe PubMed DOI PMC EPMC

2016

Jung,J.K., Jang,S.W. and Kim,J.M. A novel role for the deubiquitinase USP1 in the control of centrosome duplication Cell Cycle (2016) 15, 584-592. PubMed Europe PubMed DOI
Kim,M. and Kim,J.M. The role of USP1 autocleavage in DNA interstrand crosslink repair FEBS Lett (2016) 590, 340-348. PubMed Europe PubMed DOI
Lee,J.K., Chang,N., Yoon,Y., Yang,H., Cho,H., Kim,E., Shin,Y., Kang,W., Oh,Y.T., Mun,G.I., Joo,K.M., Nam,D.H. and Lee,J. USP1 targeting impedes GBM growth by inhibiting stem cell maintenance and radioresistance Neuro Oncol (2016) 18, 37-47. PubMed Europe PubMed DOI K I
Liu,J., Zhu,H., Zhong,N., Jiang,Z., Xu,L., Deng,Y., Jiang,Z., Wang,H. and Wang,J. Gene silencing of USP1 by lentivirus effectively inhibits proliferation and invasion of human osteosarcoma cells Int J Oncol (2016) 49, 2549-2557. PubMed Europe PubMed DOI K T
Ogrunc,M., Martinez-Zamudio,R.I., Sadoun,P.B., Dore,G., Schwerer,H., Pasero,P., Lemaitre,J.M., Dejean,A. and Bischof,O. USP1 regulates cellular senescence by controlling genomic integrity Cell Rep (2016) 15, 1401-1411. PubMed Europe PubMed DOI T
Olazabal-Herrero,A., Garcia-Santisteban,I. and Rodriguez,J.A. Mutations in the 'Fingers' subdomain of the deubiquitinase USP1 modulate its function and activity FEBS J (2016) 283, 929-946. PubMed Europe PubMed DOI M I
Rahme,G.J., Zhang,Z., Young,A.L., Cheng,C., Bivona,E.J., Fiering,S.N., Hitoshi,Y. and Israel,M.A. PDGF Engages an E2F-USP1 signaling pathway to support ID2-mediated survival of proneural glioma cells Cancer Res (2016) 76, 2964-2976. PubMed Europe PubMed DOI
Sourisseau,T., Helissey,C., Lefebvre,C., Ponsonnailles,F., Malka-Mahieu,H., Olaussen,K.A., Andre,F., Vagner,S. and Soria,J.C. Translational regulation of the mRNA encoding the ubiquitin peptidase USP1 involved in the DNA damage response as a determinant of Cisplatin resistance Cell Cycle (2016) 15, 295-302. PubMed Europe PubMed DOI

2015

Olazabal-Herrero,A., Garcia-Santisteban,I. and Rodriguez,J. Structure-function analysis of USP1: insights into the role of Ser313 phosphorylation site and the effect of cancer-associated mutations on autocleavage Mol Cancer (2015) 14, 33-33. PubMed Europe PubMed DOI PMC EPMC

2014

Liang,Q., Dexheimer,T.S., Zhang,P., Rosenthal,A.S., Villamil,M.A., You,C., Zhang,Q., Chen,J., Ott,C.A., Sun,H., Luci,D.K., Yuan,B., Simeonov,A., Jadhav,A., Xiao,H., Wang,Y., Maloney,D.J. and Zhuang,Z. A selective USP1-UAF1 inhibitor links deubiquitination to DNA damage responses Nat Chem Biol (2014) 10, 298-304. PubMed Europe PubMed DOI I

2013

Cataldo,F., Peche,L.Y., Klaric,E., Brancolini,C., Myers,M.P., Demarchi,F. and Schneider,C. CAPNS1 regulates USP1 stability and maintenance of genome integrity Mol Cell Biol (2013) 33, 2485-2496. PubMed Europe PubMed DOI
Garcia-Santisteban,I., Peters,G.J., Giovannetti,E. and Rodriguez,J.A. USP1 deubiquitinase: cellular functions, regulatory mechanisms and emerging potential as target in cancer therapy Mol Cancer (2013) 12, 91-91. PubMed Europe PubMed DOI T
Mistry,H., Hsieh,G., Buhrlage,S.J., Huang,M., Park,E., Cuny,G.D., Galinsky,I., Stone,R.M., Gray,N.S., D'Andrea,A.D. and Parmar,K. Small-molecule inhibitors of USP1 target ID1 degradation in leukemic cells Mol Cancer Ther (2013) 12, 2651-2662. PubMed Europe PubMed DOI I
Park,E., Kim,J.M., Primack,B., Weinstock,D.M., Moreau,L.A., Parmar,K. and D'Andrea,A.D. Inactivation of Uaf1 causes defective homologous recombination and early embryonic lethality in mice Mol Cell Biol (2013) 33, 4360-4370. PubMed Europe PubMed DOI K
Villamil,M.A., Liang,Q. and Zhuang,Z. The WD40-repeat protein-containing deubiquitinase complex: catalysis, regulation, and potential for therapeutic intervention Cell Biochem Biophys (2013) 67, 111-126. PubMed Europe PubMed DOI

2012

Bekes,M. and Huang,T.T. Ubiquitin-specific peptidase 1 [ISSN:978-0-12-407743-0] (2012) 3, 2079-2085. DOI
Cotto-Rios,X.M., Bekes,M., Chapman,J., Ueberheide,B. and Huang,T.T. Deubiquitinases as a signaling target of oxidative stress Cell Rep (2012) 2, 1475-1484. PubMed Europe PubMed DOI
Piatkov,K.I., Colnaghi,L., Bekes,M., Varshavsky,A. and Huang,T.T. The auto-generated fragment of the Usp1 deubiquitylase is a physiological substrate of the N-end rule pathway Mol Cell (2012) 48, 926-933. PubMed Europe PubMed DOI
Villamil,M.A., Chen,J., Liang,Q. and Zhuang,Z. A noncanonical cysteine protease USP1 is activated through active site modulation by USP1-associated factor 1 Biochemistry (2012) 51, 2829-2839. PubMed Europe PubMed DOI
Villamil,M.A., Liang,Q., Chen,J., Choi,Y.S., Hou,S., Lee,K.H. and Zhuang,Z. Serine phosphorylation is critical for the activation of ubiquitin-specific protease 1 and its interaction with WD40-repeat protein UAF1 Biochemistry (2012) 51, 9112-9123. PubMed Europe PubMed DOI

2011

ID Proteins are stabilized by USP1 Cancer Discov (2011) 1, 375-375. DOI
Chen,J., Dexheimer,T.S., Ai,Y., Liang,Q., Villamil,M.A., Inglese,J., Maloney,D.J., Jadhav,A., Simeonov,A. and Zhuang,Z. Selective and cell-active inhibitors of the USP1/ UAF1 deubiquitinase complex reverse cisplatin resistance in non-small cell lung cancer cells Chem Biol (2011) 18, 1390-1400. PubMed Europe PubMed DOI T I
Cotto-Rios,X.M., Jones,M.J., Busino,L., Pagano,M. and Huang,T.T. APC/CCdh1-dependent proteolysis of USP1 regulates the response to UV-mediated DNA damage J Cell Biol (2011) 194, 177-186. PubMed Europe PubMed DOI
Faesen,A.C., Luna-Vargas,M.P., Geurink,P.P., Clerici,M., Merkx,R., van Dijk,W.J., Hameed,D.S., El Oualid,F., Ovaa,H. and Sixma,T.K. The differential modulation of USP activity by internal regulatory domains, interactors and eight ubiquitin chain types Chem Biol (2011) 18, 1550-1561. PubMed Europe PubMed DOI
Guervilly,J.H., Renaud,E., Takata,M. and Rosselli,F. USP1 deubiquitinase maintains phosphorylated CHK1 by limiting its DDB1-dependent degradation Hum Mol Genet (2011) 20, 2171-2181. PubMed Europe PubMed DOI
Murai,J., Yang,K., Dejsuphong,D., Hirota,K., Takeda,S. and D'Andrea,A.D. The USP1/UAF1 complex promotes double-strand break repair through homologous recombination Mol Cell Biol (2011) 31, 2462-2469. PubMed Europe PubMed DOI
Williams,S.A., Maecker,H.L., French,D.M., Liu,J., Gregg,A., Silverstein,L.B., Cao,T.C., Carano,R.A. and Dixit,V.M. USP1 deubiquitinates ID proteins to preserve a mesenchymal stem cell program in osteosarcoma Cell (2011) 146, 918-930. PubMed Europe PubMed DOI
Wrighton,K.H. Mechanisms of disease: USP1 keeps ID proteins stable Nat Rev Mol Cell Biol (2011) 12, 691-691. PubMed Europe PubMed DOI
Wrighton,K.H. Tumorigenesis: USP1 keeps ID proteins stable Nat Rev Cancer (2011) 11, 757-757. PubMed Europe PubMed DOI
Yang,K., Moldovan,G.L., Vinciguerra,P., Murai,J., Takeda,S. and D'Andrea,A.D. Regulation of the Fanconi anemia pathway by a SUMO-like delivery network Genes Dev (2011) 25, 1847-1858. PubMed Europe PubMed DOI

2009

Kim,J.M., Parmar,K., Huang,M., Weinstock,D.M., Ruit,C.A., Kutok,J.L. and D'Andrea,A.D. Inactivation of murine Usp1 results in genomic instability and a fanconi anemia phenotype Dev Cell (2009) 16, 314-320. PubMed Europe PubMed DOI K

2007

Oestergaard,V.H., Langevin,F., Kuiken,H.J., Pace,P., Niedzwiedz,W., Simpson,L.J., Ohzeki,M., Takata,M., Sale,J.E. and Patel,K.J. Deubiquitination of FANCD2 is required for DNA crosslink repair Mol Cell (2007) 28, 798-809. PubMed Europe PubMed DOI PMC EPMC K

2006

Huang,T.T., Nijman,S.M., Mirchandani,K.D., Galardy,P.J., Cohn,M.A., Haas,W., Gygi,S.P., Ploegh,H.L., Bernards,R. and D'Andrea,A.D. Regulation of monoubiquitinated PCNA by DUB autocleavage Nat Cell Biol (2006) 8, 339-347. PubMed Europe PubMed DOI

2005

Nijman,S.M., Huang,T.T., Dirac,A.M., Brummelkamp,T.R., Kerkhoven,R.M., D'Andrea,A.D. and Bernards,R. The deubiquitinating enzyme USP1 regulates the Fanconi anemia pathway Mol Cell (2005) 17, 331-339. PubMed Europe PubMed DOI

1998

[YEAR:15-11-1998]Fujiwara,T., Saito,A., Suzuki,M., Shinomiya,H., Suzuki,T., Takahashi,E., Tanigami,A., Ichiyama,A., Chung,C.H., Nakamura,Y. and Tanaka,K. Identification and chromosomal assignment of USP1, a novel gene encoding a human ubiquitin-specific protease Genomics (15-11-1998) 54, 155-158. PubMed Europe PubMed DOI