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Literature for peptidase C19.014: ubiquitin-specific peptidase 11

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

(Topics flags: S Structure, K Knockout, I Inhibitor, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2026
  1. Kayastha,F., Herrington,N.B., Roychowdhury,A., Nanaji,N.M., Lee,W.S., Kellogg,G.E., Kapadia,B. and Gartenhaus,R.B.
    Discovery, development, and characterization of potent and selective USP11 inhibitors
    Pharmacol Res (2026) 223, 108075-108075. PubMed  Europe PubMed DOI
    2. 2025
  2. Chen,C., Chen,Z., Luo,R., Tu,W., Long,M., Liang,M., Cheng,M., Wang,Z., Huang,K. and Wang,C.
    Endothelial USP11 drives VEGFR2 signaling and angiogenesis via PRDX2/c-MYC axis
    Angiogenesis (2025) 28, 23-23. PubMed  Europe PubMed DOI
  3. Deng,Z., Zhou,F., Li,M., Jin,W., Yu,J., Wang,G., Qian,K., Ju,L., Zhang,Y., Xiao,Y. and Wang,X.
    DLGAP5 enhances bladder cancer chemoresistance by regulating glycolysis through MYC stabilization
    Theranostics (2025) 15, 2375-2392. PubMed  Europe PubMed DOI  PMC  EPMC
  4. Gao,B., Jing,Y., Li,X. and Cong,S.
    Ubiquitin specific peptidase 11 knockdown slows Huntington's disease progression via regulating mitochondrial dysfunction and neuronal damage depending on PTEN-mediated AKT pathway
    Mol Med (2025) 31, 7-7. PubMed  Europe PubMed DOI  PMC  EPMC
  5. He,J., Qin,Z., Cai,Y., Liu,H., Wang,T., Hu,Q., Xu,Y., Yang,P., Wu,X., Qu,Y. and Guo,W.
    USP11-PGAM5 Axis Promotes Neurotoxic Astrocyte Reactivity by Aggravating the mtDNA-cGAS-STING Pathway After Intracerebral Hemorrhage
    Adv Sci (Weinh) (2025) , e14283-e14283. PubMed  Europe PubMed DOI
  6. Iwase,R., Maisonet,I.J., Lee,K., Buhrlage,S.J. and Cole,P.A.
    Deubiquitinase processing of a non-natural linkage of ubiquitinated-PTEN
    Bioorg Chem (2025) 157, 108223-108223. PubMed  Europe PubMed DOI
  7. Karapurkar,J.K., Rajkumar,S., Jung,J.H., Kim,J.Y., Birappa,G., Gowda,D.A.A., Colaco,J.C., Suresh,B., Choi,J.Y., Woo,S.H., Jo,W.J., Lee,J.H., Kim,K.S., Hong,S.H. and Ramakrishna,S.
    Targeting USP11 counteracts SFTPC(I73T) -associated interstitial lung disease in hiPSCs-derived alveolar organoids and in vivo models
    Theranostics (2025) 15, 4526-4549. PubMed  Europe PubMed DOI  PMC  EPMC
  8. Lee,H., Hurh,S., Kang,S., Yoon,J., Hwang,J.I., Logan,D.T. and Kim,H.R.
    Identification of chemical scaffolds for targeting ubiquitin-specific protease 11 (USP11) through high-throughput virtual screening
    J Enzyme Inhib Med Chem (2025) 40, 2518191-2518191. PubMed  Europe PubMed DOI  PMC  EPMC
  9. Lee,S.R., Chen,H.H., Chen,R.H. and Wu,K.P.
    Non-catalytic UBL2 domain directs deubiquitinase USP11 toward K48-linked polyubiquitin chains
    J Biol Chem (2025) 301, 110924-110924. PubMed  Europe PubMed DOI
  10. Liu,J.X., Zhang,Y.K., Zhan,W., Xie,J.H., Xu,Q.H., Zhang,J. and Tai,X.
    USP11 promotes autophagy to attenuate LPS-induced oxidative stress in lung epithelial cells by stabilizing FOXO1 levels
    Biochem Biophys Res Commun (2025) 751, 151368-151368. PubMed  Europe PubMed DOI
  11. Rajkumar,S., Jung,J.H., Kim,J.Y., Karapurkar,J.K., Birappa,G., Gowda,D.A.A., Ajaykumar,C.B., Perumalsamy,H., Suresh,B., Kim,K.S., Hong,S.H. and Ramakrishna,S.
    Loss of Ubiquitin-Specific Protease 11 Mitigates Pulmonary Fibrosis in Human Pluripotent Stem Cell-Derived Alveolar Organoids
    Int J Stem Cells (2025) PubMed  Europe PubMed DOI
  12. Sheng,J., Wu,D., Shang,J., Fu,X., Gao,H., Rong,J., Wang,J., Hu,J. and Qi,X.
    Usp11 maintained the survival of marginal zone B cells under ionizing radiation by deubiquitinating DLL1 and JAG2
    Cell Death Dis (2025) 16, 67-67. PubMed  Europe PubMed DOI  PMC  EPMC
  13. Shin,J.H., Kim,J.Y., Kim,S.H., Kang,Y., Lee,H.J., Kim,M.J., Choi,J., Jeong,S.K., Park,S.O., Cho,Y.B., Kim,K.K., Shim,J.H., Chun,E. and Lee,K.Y.
    USP11 promotes colorectal cancer progression by stabilizing EGFR and TRAF6: a potential therapeutic target in EGFR- and TLR-driven tumorigenesis
    Cell Death Dis (2025) 16, 894-894. PubMed  Europe PubMed DOI  PMC  EPMC
  14. Turi da Fonte Dias,A.R. and Hoffmann,I.
    The E3 ubiquitin ligase SPRYD3-MYCBP2(PAM) regulates mitotic cell fate and ubiquitination of USP11 to control spindle assembly
    J Biol Chem (2025) , 110785-110785. PubMed  Europe PubMed DOI
  15. Wang,L., Tang,W., Jiang,L., Zhang,D., Wang,Z., Guo,R., Wang,J. and Xiao,D.
    Inhibition of USP11 attenuates sepsis-associated acute kidney injury by downregulating TGFBR2/Smad3 signaling
    Front Mol Biosci (2025) 12, 1571593-1571593. PubMed  Europe PubMed DOI  PMC  EPMC
  16. Wang,X., Xie,X., Ni,J.Y., Li,J.Y., Sun,X.A., Xie,H.Y., Yang,N.H., Guo,H.J., Lu,L., Ning,M., Zhou,L., Liu,J., Xu,C., Zhang,W., Wen,Y., Shen,Q., Xu,H. and Lu,L.M.
    USP11 promotes renal tubular cell pyroptosis and fibrosis in UUO mice via inhibiting KLF4 ubiquitin degradation
    Acta Pharmacol Sin (2025) 46, 159-170. PubMed  Europe PubMed DOI
  17. Yonezawa,T., Rutter,J., Ramabadran,R., Sundaramurthy,V., Datar,G., Slabicki,M. and Goodell,M.A.
    DNMT3A Stability Is Maintained by Ubiquitin-Specific Peptidase 11 (USP11) and Sumoylation Countering Degradation
    bioRxiv (2025) PubMed  Europe PubMed DOI  PMC  EPMC
  18. Zhang,J., Allen,J., Ward,S.J., Dekker,L.V. and Dreveny,I.
    A versatile fluorescence polarization based deubiquitination assay using an isopeptide bond substrate mimetic (IsoMim)
    J Biol Chem (2025) , 110342-110342. PubMed  Europe PubMed DOI  I
  19. Zhang,T., Liu,Y., Liu,F., Guo,K., Tang,R., Ye,J., Xue,L., Su,Z. and Wu,Z.B.
    X-linked ubiquitin-specific peptidase 11 (USP11) increases susceptibility to Cushing's disease in women
    Acta Neuropathol Commun (2025) 13, 22-22. PubMed  Europe PubMed DOI  PMC  EPMC  K
    20. 2024
  20. Chen,J., Ning,D., Du,P., Liu,Q., Mo,J., Liang,H., Zhang,W., Zhang,M., Jiang,L., Zhang,B. and Chen,X.
    USP11 potentiates HGF/AKT signaling and drives metastasis in hepatocellular carcinoma
    Oncogene (2024) 43, 123-135. PubMed  Europe PubMed DOI
  21. Cui,L., Yang,L., Lai,B., Luo,L., Deng,H., Chen,Z. and Wang,Z.
    Integrative and comprehensive pan-cancer analysis of ubiquitin specific peptidase 11 (USP11) as a prognostic and immunological biomarker
    Heliyon (2024) 10, e34523-e34523. PubMed  Europe PubMed DOI  PMC  EPMC
  22. Ebina,M., Miura,Y. and Sakane,F.
    Ubiquitin-specific peptidase 11 selectively interacts with and deubiquitination-dependently stabilizes diacylglycerol kinase delta to maintain cellular glucose uptake
    Biochim Biophys Acta Mol Cell Res (2024) 1872, 119883-119883. PubMed  Europe PubMed DOI  K
  23. Ge,C., Huang,M., Han,Y., Shou,C., Li,D. and Zhang,Y.
    Demethyleneberberine Alleviates Pulmonary Fibrosis through Disruption of USP11 Deubiquitinating GREM1
    Pharmaceuticals (Basel) (2024) 17 PubMed  Europe PubMed DOI  PMC  EPMC
  24. Guo,Y., Cai,C., Zhang,B., Tan,B., Tang,Q., Lei,Z., Qi,X., Chen,J., Zheng,X., Zi,D., Li,S. and Tan,J.
    Targeting USP11 regulation by a novel lithium-organic coordination compound improves neuropathologies and cognitive functions in Alzheimer transgenic mice
    EMBO Mol Med (2024) 16, 2856-2881. PubMed  Europe PubMed DOI
  25. Kim,W.J., Basit,A. and Lee,J.H.
    USP11 modulates mitotic progression and senescence by regulating the p53-p21 axis through MDM2 deubiquitination
    Biochem Biophys Res Commun (2024) 726, 150275-150275. PubMed  Europe PubMed DOI
  26. Li,T., Huang,J., Zeng,A., Yu,N. and Long,X.
    Ubiquitin-specific peptidase 11 promotes development of keloid derived fibroblasts by de-ubiquitinating TGF-beta receptorII
    Burns (2024) 50, 641-652. PubMed  Europe PubMed DOI  K
  27. Liu,Y., Li,D., Zhang,X., Xia,S., Qu,Y., Ling,X., Li,Y., Kong,X., Zhang,L., Cui,C.P. and Li,D.
    A protein sequence-based deep transfer learning framework for identifying human proteome-wide deubiquitinase-substrate interactions
    Nat Commun (2024) 15, 4519-4519. PubMed  Europe PubMed DOI  PMC  EPMC
  28. Qian,T., Bai,F., Zhang,S., Xu,Y., Wang,Y., Yuan,S., Liu,X., Du,Y., Peng,B., Zhu,W.G., Xu,X. and Pei,X.H.
    USP11 deubiquitinates E-cadherin and maintains luminal fate of mammary tumor cells to suppress breast cancer
    J Biol Chem (2024) , 107768-107768. PubMed  Europe PubMed DOI
  29. Qiao,L., Hu,W., Li,L., Chen,X., Liu,L. and Wang,J.
    USP11 promotes glycolysis by regulating HIF-1alpha stability in hepatocellular carcinoma
    J Cell Mol Med (2024) 28, e18017-e18017. PubMed  Europe PubMed DOI  PMC  EPMC
  30. Ryu,E., Yoo,J., Kang,M.S., Ha,N.Y., Jang,Y., Kim,J., Kim,Y., Kim,B.G., Kim,S., Myung,K. and Kang,S.
    ATAD5 functions as a regulatory platform for Ub-PCNA deubiquitination
    Proc Natl Acad Sci U S A (2024) 121, e2315759121-e2315759121. PubMed  Europe PubMed DOI
  31. Tang,Y., Wang,T., Gu,L., Xu,Y., Yang,Z., Zhu,W., Zhang,Q., Luo,J., Cao,J. and Jiao,Y.
    USP11 Exacerbates Radiation-Induced Pneumonitis by Activating Endothelial Cell Inflammatory Response via OTUD5-STING Signaling
    Int J Radiat Oncol Biol Phys (2024) 119, 1261-1274. PubMed  Europe PubMed DOI  I
  32. Xu,Y., Zeng,J., Liu,K., Li,D., Huang,S., Fu,S., Ye,M., Tao,S. and Wu,J.
    USP11 promotes lipogenesis and tumorigenesis by regulating SREBF1 stability in hepatocellular carcinoma
    Cell Commun Signal (2024) 22, 550-550. PubMed  Europe PubMed DOI  PMC  EPMC  K
  33. Zhang,N., Wang,Q., Lu,Y., Wang,F. and He,Z.
    The deubiquitinating enzyme USP11 regulates breast cancer progression by stabilizing PGAM5
    Breast Cancer Res (2024) 26, 135-135. PubMed  Europe PubMed DOI  PMC  EPMC  K
    34. 2023
  34. Boehm,D., Lam,V., Schnolzer,M. and Ott,M.
    The lysine methyltransferase SMYD5 amplifies HIV-1 transcription and is post-transcriptionally upregulated by Tat and USP11
    Cell Rep (2023) 42, 112234-112234. PubMed  Europe PubMed DOI  PMC  EPMC  K
  35. Deng,T., Xie,L., Xiaofang,C., Zhang,Z., Xiao,Y., Peng,Y., Yin,L., Fu,Y. and Li,X.
    ATM-Mediated translocation of RanBPM regulates DNA damage response by stabilizing p21 in non-small cell lung cancer cells
    Cell Oncol (Dordr) (2023) PubMed  Europe PubMed DOI
  36. Duan,J., Huang,D., Liu,C., Lv,Y., Zhang,L., Chang,F., Zeng,X., Li,L., Wang,W. and Shao,G.
    USP11-mediated LSH deubiquitination inhibits ferroptosis in colorectal cancer through epigenetic activation of CYP24A1
    Cell Death Dis (2023) 14, 402-402. PubMed  Europe PubMed DOI  PMC  EPMC
  37. Fang,Y., Zhao,T., Ni,H., Li,Y., Zhu,Y., Gao,R., Zhang,L., Jia,Z. and Chen,G.
    USP11 exacerbates neuronal apoptosis after traumatic brain injury via PKM2-mediated PI3K/AKT signaling pathway
    Brain Res (2023) 1807, 148321-148321. PubMed  Europe PubMed DOI
  38. Ghoreshi,Z.A., Molaei,H.R. and Arefinia,N.
    The Role of DNA Viruses in Human Cancer
    Cancer Inform (2023) 22, 11769351231154186-11769351231154186. PubMed  Europe PubMed DOI  PMC  EPMC  V
  39. Maurer,S.K., Mayer,M.P., Ward,S.J., Boudjema,S., Halawa,M., Zhang,J., Caulton,S.G., Emsley,J. and Dreveny,I.
    Ubiquitin-specific protease 11 structure in complex with an engineered substrate mimetic reveals a molecular feature for deubiquitination selectivity
    J Biol Chem (2023) 299, 105300-105300. PubMed  Europe PubMed DOI  PMC  EPMC
  40. Shi,Y., Tao,M., Chen,H., Ma,X., Wang,Y., Hu,Y., Zhou,X., Li,J., Cui,B., Qiu,A., Zhuang,S. and Liu,N.
    Ubiquitin-specific protease 11 promotes partial epithelial-to-mesenchymal transition by deubiquitinating the epidermal growth factor receptor during kidney fibrosis
    Kidney Int (2023) 103, 544-564. PubMed  Europe PubMed DOI
  41. Zhang,Y., Hailati,J., Ma,X., Midilibieke,H. and Liu,Z.
    Ubiquitin-specific protease 11 Aggravates Ischemia-reperfusion-induced Cardiomyocyte Pyroptosis and Injury by Promoting TRAF3 Deubiquitination
    Balkan Med J (2023) 40, 205-214. PubMed  Europe PubMed DOI  PMC  EPMC  K
  42. Zhu,J., Sun,R., Sun,K., Yan,C., Jiang,J., Kong,F. and Shi,J.
    The deubiquitinase USP11 ameliorates intervertebral disc degeneration by regulating oxidative stress-induced ferroptosis via deubiquitinating and stabilizing Sirt3
    Redox Biol (2023) 62, 102707-102707. PubMed  Europe PubMed DOI  PMC  EPMC
    43. 2022
  43. Gao,Y., Chen,B., Wang,R., Xu,A., Wu,L., Lu,H. and Zhao,G.
    Knockdown of RRM1 in tumor cells promotes radio-/chemotherapy induced ferroptosis by regulating p53 ubiquitination and p21-GPX4 signaling axis
    Cell Death Discov (2022) 8, 343-343. PubMed  Europe PubMed DOI  PMC  EPMC
  44. Guo,T., Tang,H., Yuan,Z., Zhang,E. and Wang,X.
    The Dual Role of USP11 in Cancer
    J Oncol (2022) 2022, 9963905-9963905. PubMed  Europe PubMed DOI  PMC  EPMC  V
  45. Kaushal,K., Tyagi,A., Karapurkar,J.K., Kim,E.J., Tanguturi,P., Kim,K.S., Jung,H.S. and Ramakrishna,S.
    Genome-Wide CRISPR/Cas9-Based Screening for Deubiquitinase Subfamily Identifies Ubiquitin-Specific Protease 11 as a Novel Regulator of Osteogenic Differentiation
    Int J Mol Sci (2022) 23 PubMed  Europe PubMed DOI  PMC  EPMC
  46. Li,L., Deng,T., Zhang,L., Wang,Y., Zhou,Y., Liu,Y., Li,H., Dai,J., Yang,Y., Ling,N., Liu,H., Liu,J., Cao,L., Xu,M. and Ye,M.
    ERK-mediated Cytoplasmic Retention of USP11 Contributes to Breast Cancer Cell Proliferation by Stabilizing Cytoplasmic p21
    Int J Biol Sci (2022) 18, 2568-2582. PubMed  Europe PubMed DOI  PMC  EPMC
  47. Ni,J.Y., Wang,X., Xie,H.Y., Yang,N.H., Li,J.Y., Sun,X.A., Guo,H.J., Zhou,L., Zhang,W., Liu,J. and Lu,L.M.
    Deubiquitinating enzyme USP11 promotes renal tubular cell senescence and fibrosis via inhibiting the ubiquitin degradation of TGF-beta receptor II
    Acta Pharmacol Sin (2022) PubMed  Europe PubMed DOI  K
  48. Paul,B.D.
    DUB'ling down uncovers an X-linked vulnerability in Alzheimer's disease
    Cell (2022) 185, 3854-3856. PubMed  Europe PubMed DOI
  49. Zhang,W., Li,X., Xu,J., Wang,Y., Xing,Z., Hu,S., Fan,Q., Lu,S., Cheng,J., Gu,J. and Cai,R.
    The RSL3 Induction of KLK Lung Adenocarcinoma Cell Ferroptosis by Inhibition of USP11 Activity and the NRF2-GSH Axis
    Cancers (Basel) (2022) 14 PubMed  Europe PubMed DOI  PMC  EPMC
    50. 2021
  50. Basic,M., Hertel,A., Bajdzienko,J., Bonn,F., Tellechea,M., Stolz,A., Kern,A., Behl,C. and Bremm,A.
    The deubiquitinase USP11 is a versatile and conserved regulator of autophagy
    J Biol Chem (2021) 297, 101263-101263. PubMed  Europe PubMed DOI  PMC  EPMC
  51. Jurga,M., Abugable,A.A., Goldman,A.S.H. and El-Khamisy,S.F.
    USP11 controls R-loops by regulating senataxin proteostasis
    Nat Commun (2021) 12, 5156-5156. PubMed  Europe PubMed DOI  PMC  EPMC
  52. Liu,H., Liu,M., He,B. and Li,Q.
    Inhibition of USP11 sensitizes gastric cancer to chemotherapy via suppressing RhoA and Ras-mediated signaling pathways
    Clin Res Hepatol Gastroenterol (2021) , 101779-101779. PubMed  Europe PubMed DOI  K
  53. Meng,C., Zhan,J., Chen,D., Shao,G., Zhang,H., Gu,W. and Luo,J.
    The deubiquitinase USP11 regulates cell proliferation and ferroptotic cell death via stabilization of NRF2 USP11 deubiquitinates and stabilizes NRF2
    Oncogene (2021) PubMed  Europe PubMed DOI
  54. Perry,M., Biegert,M., Kollala,S.S., Mallard,H., Su,G., Kodavati,M., Kreiling,N., Holbrook,A. and Ghosal,G.
    USP11 mediates repair of DNA-protein crosslinks by deubiquitinating SPRTN metalloprotease
    J Biol Chem (2021) , 100396-100396. PubMed  Europe PubMed DOI
  55. Qiao,L., Zhang,Q., Sun,Z., Liu,Q., Wu,Z., Hu,W., Bao,S., Yang,Q. and Liu,L.
    The E2F1/USP11 positive feedback loop promotes hepatocellular carcinoma metastasis and inhibits autophagy by activating ERK/mTOR pathway
    Cancer Lett (2021) 514, 63-78. PubMed  Europe PubMed DOI
  56. Rong,Y., Fan,J., Ji,C., Wang,Z., Ge,X., Wang,J., Ye,W., Yin,G., Cai,W. and Liu,W.
    USP11 regulates autophagy-dependent ferroptosis after spinal cord ischemia-reperfusion injury by deubiquitinating Beclin 1
    Cell Death Differ (2021) PubMed  Europe PubMed DOI
  57. Sun,H., Wang,R., Liu,Y., Mei,H., Liu,X. and Peng,Z.
    USP11 induce resistance to 5-Fluorouracil in Colorectal Cancer through activating autophagy by stabilizing VCP
    J Cancer (2021) 12, 2317-2325. PubMed  Europe PubMed DOI  PMC  EPMC
  58. Tang,Y., Yuan,Q., Zhao,C., Xu,Y., Zhang,Q., Wang,L., Sun,Z., Cao,J., Luo,J. and Jiao,Y.
    Targeting USP11 may alleviate radiation-induced pulmonary fibrosis by regulating endothelium tight junction
    Int J Radiat Biol (2021) , 1-11. PubMed  Europe PubMed DOI
  59. Yang,H., Park,D., Ryu,J. and Park,T.
    USP11 degrades KLF4 via its deubiquitinase activity in liver diseases
    J Cell Mol Med (2021) 25, 6976-6987. PubMed  Europe PubMed DOI
  60. Zhang,W., Wang,Z., Cai,G. and Huang,P.
    Circ_DOCK1 regulates USP11 through miR-132-3p to control colorectal cancer progression
    World J Surg Oncol (2021) 19, 67-67. PubMed  Europe PubMed DOI  PMC  EPMC
  61. Zhang,X., Liu,T., Xu,S., Gao,P., Dong,W., Liu,W., Gao,M., Song,L., Cui,L. and Dong,X.
    A pro-inflammatory mediator USP11 enhances the stability of p53 and inhibits KLF2 in intracerebral hemorrhage
    Mol Ther Methods Clin Dev (2021) 21, 681-692. PubMed  Europe PubMed DOI  PMC  EPMC  K
    62. 2020
  62. Bai,M., Che,Y., Lu,K. and Fu,L.
    Analysis of deubiquitinase OTUD5 as a biomarker and therapeutic target for cervical cancer by bioinformatic analysis
    PeerJ (2020) 8, e9146-e9146. PubMed  Europe PubMed DOI  PMC  EPMC
  63. Feng,P., Li,L., Dai,J., Zhou,L., Liu,J., Zhao,J., Li,X., Ling,N., Qiu,S., Zhang,L., Xie,T., Chen,Y., Donovan,M.J., Peng,T., Song,J. and Ye,M.
    The regulation of NONO by USP11 via deubiquitination is linked to the proliferation of melanoma cells
    J Cell Mol Med (2020) PubMed  Europe PubMed DOI  K
  64. Huang,D., Liu,C., Sun,X., Sun,X., Qu,Y., Tang,Y., Li,G. and Tong,T.
    CRL4(DCAF8) and USP11 oppositely regulate the stability of myeloid leukemia factors (MLFs)
    Biochem Biophys Res Commun (2020) 529, 127-132. PubMed  Europe PubMed DOI
    65. 2019
  65. Istomine,R., Alvarez,F., Almadani,Y., Philip,A. and Piccirillo,C.A.
    The deubiquitinating enzyme ubiquitin-specific peptidase 11 potentiates TGF-beta signaling in CD4(+) T Cells to facilitate Foxp3(+) regulatory T and TH17 cell differentiation
    J Immunol (2019) 203, 2388-2400. PubMed  Europe PubMed DOI
  66. Maupin-Furlow,J.A.
    Putting phage to work in deubiquitinase ligand discovery
    J Biol Chem (2019) 294, 437-438. PubMed  Europe PubMed DOI  PMC  EPMC
  67. Spiliotopoulos,A., Blokpoel Ferreras,L., Densham,R.M., Caulton,S.G., Maddison,B.C., Morris,J.R., Dixon,J.E., Gough,K.C. and Dreveny,I.
    Discovery of peptide ligands targeting a specific ubiquitin-like domain-binding site in the deubiquitinase USP11
    J Biol Chem (2019) 294, 424-436. PubMed  Europe PubMed DOI
  68. Sun,H., Ou,B., Zhao,S., Liu,X., Song,L., Liu,X., Wang,R. and Peng,Z.
    USP11 promotes growth and metastasis of colorectal cancer via PPP1CA-mediated activation of ERK/MAPK signaling pathway
    EBioMedicine (2019) 48, 236-247. PubMed  Europe PubMed DOI
  69. Ting,X., Xia,L., Yang,J., He,L., Si,W., Shang,Y. and Sun,L.
    USP11 acts as a histone deubiquitinase functioning in chromatin reorganization during DNA repair
    Nucleic Acids Res (2019) 47, 9721-9740. PubMed  Europe PubMed DOI
  70. Wang,W., Wang,J., Yan,H., Zhang,K. and Liu,Y.
    Upregulation of USP11 promotes epithelial to mesenchymal transition by deubiquitinating Snail in ovarian cancer
    Oncol Rep (2019) 41, 1739-1748. PubMed  Europe PubMed DOI
    71. 2018
  71. Stockum,A., Snijders,A.P. and Maertens,G.N.
    USP11 deubiquitinates RAE1 and plays a key role in bipolar spindle formation
    PLoS ONE (2018) 13, e0190513-e0190513. PubMed  Europe PubMed DOI
    72. 2017
  72. Zhou,Z., Luo,A., Shrivastava,I., He,M., Huang,Y., Bahar,I., Liu,Z. and Wan,Y.
    Regulation of XIAP turnover reveals a role for USP11 in promotion of tumorigenesis
    EBioMedicine (2017) 15, 48-61. PubMed  Europe PubMed DOI
    73. 2016
  73. Jacko,A.M., Nan,L., Li,S., Tan,J., Zhao,J., Kass,D.J. and Zhao,Y.
    De-ubiquitinating enzyme, USP11, promotes transforming growth factor beta-1 signaling through stabilization of transforming growth factor beta receptor II
    Cell Death Dis (2016) 7, e2474-e2474. PubMed  Europe PubMed DOI
  74. Lee,E.W. and Song,J.
    USP11: a key regulator of cIAP2 stability and sensitivity to SMAC mimetics
    Mol Cell Oncol (2016) 3, e1029829-e1029829. PubMed  Europe PubMed DOI  PMC  EPMC
  75. Lim,K.H., Suresh,B., Park,J.H., Kim,Y.S., Ramakrishna,S. and Baek,K.H.
    Ubiquitin-specific protease 11 functions as a tumor suppressor by modulating Mgl-1 protein to regulate cancer cell growth
    Oncotarget (2016) 7, 14441-14457. PubMed  Europe PubMed DOI
  76. Xu,Z., Li,X., Chen,J., Zhao,J., Wang,J., Ji,Y., Shen,Y., Han,L., Shi,J. and Zhang,D.
    USP11, deubiquitinating enzyme, associated with neuronal apoptosis following intracerebral hemorrhage
    J Mol Neurosci (2016) 58, 16-27. PubMed  Europe PubMed DOI
  77. Yu,M., Liu,K., Mao,Z., Luo,J., Gu,W. and Zhao,W.
    USP11 is a Negative Regulator to gammaH2AX Ubiquitylation by RNF8/RNF168
    J Biol Chem (2016) 291, 959-967. PubMed  Europe PubMed DOI
  78. Zhang,E., Shen,B., Mu,X., Qin,Y., Zhang,F., Liu,Y., Xiao,J., Zhang,P., Wang,C., Tan,M. and Fan,Y.
    Ubiquitin-specific protease 11 (USP11) functions as a tumor suppressor through deubiquitinating and stabilizing VGLL4 protein
    Am J Cancer Res (2016) 6, 2901-2909. PubMed  Europe PubMed  PMC  EPMC
    79. 2015
  79. Hendriks,I.A., Schimmel,J., Eifler,K., Olsen,J.V. and Vertegaal,A.C.
    Ubiquitin-specific protease 11 (USP11) deubiquitinates hybrid small ubiquitin-like modifier (SUMO)-ubiquitin chains to counteract RING finger protein 4 (RNF4)
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