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Literature for peptidase C19.014: ubiquitin-specific peptidase 11

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

(Topics flags: S Structure, K Knockout, I Inhibitor, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2026
  1. Kayastha,F., Herrington,N.B., Roychowdhury,A., Nanaji,N.M., Lee,W.S., Kellogg,G.E., Kapadia,B. and Gartenhaus,R.B.<br>Discovery, development, and characterization of potent and selective USP11 inhibitors<br>Pharmacol Res (2026) 223, 108075-108075. PubMed  Europe PubMed DOI
    2. 2025
  2. Chen,C., Chen,Z., Luo,R., Tu,W., Long,M., Liang,M., Cheng,M., Wang,Z., Huang,K. and Wang,C.<br>Endothelial USP11 drives VEGFR2 signaling and angiogenesis via PRDX2/c-MYC axis<br>Angiogenesis (2025) 28, 23-23. PubMed  Europe PubMed DOI
  3. Deng,Z., Zhou,F., Li,M., Jin,W., Yu,J., Wang,G., Qian,K., Ju,L., Zhang,Y., Xiao,Y. and Wang,X.<br>DLGAP5 enhances bladder cancer chemoresistance by regulating glycolysis through MYC stabilization<br>Theranostics (2025) 15, 2375-2392. PubMed  Europe PubMed DOI  PMC  EPMC
  4. Gao,B., Jing,Y., Li,X. and Cong,S.<br>Ubiquitin specific peptidase 11 knockdown slows Huntington's disease progression via regulating mitochondrial dysfunction and neuronal damage depending on PTEN-mediated AKT pathway<br>Mol Med (2025) 31, 7-7. PubMed  Europe PubMed DOI  PMC  EPMC
  5. He,J., Qin,Z., Cai,Y., Liu,H., Wang,T., Hu,Q., Xu,Y., Yang,P., Wu,X., Qu,Y. and Guo,W.<br>USP11-PGAM5 Axis Promotes Neurotoxic Astrocyte Reactivity by Aggravating the mtDNA-cGAS-STING Pathway After Intracerebral Hemorrhage<br>Adv Sci (Weinh) (2025) , e14283-e14283. PubMed  Europe PubMed DOI
  6. Iwase,R., Maisonet,I.J., Lee,K., Buhrlage,S.J. and Cole,P.A.<br>Deubiquitinase processing of a non-natural linkage of ubiquitinated-PTEN<br>Bioorg Chem (2025) 157, 108223-108223. PubMed  Europe PubMed DOI
  7. Karapurkar,J.K., Rajkumar,S., Jung,J.H., Kim,J.Y., Birappa,G., Gowda,D.A.A., Colaco,J.C., Suresh,B., Choi,J.Y., Woo,S.H., Jo,W.J., Lee,J.H., Kim,K.S., Hong,S.H. and Ramakrishna,S.<br>Targeting USP11 counteracts SFTPC(I73T) -associated interstitial lung disease in hiPSCs-derived alveolar organoids and in vivo models<br>Theranostics (2025) 15, 4526-4549. PubMed  Europe PubMed DOI  PMC  EPMC
  8. Lee,H., Hurh,S., Kang,S., Yoon,J., Hwang,J.I., Logan,D.T. and Kim,H.R.<br>Identification of chemical scaffolds for targeting ubiquitin-specific protease 11 (USP11) through high-throughput virtual screening<br>J Enzyme Inhib Med Chem (2025) 40, 2518191-2518191. PubMed  Europe PubMed DOI  PMC  EPMC
  9. Lee,S.R., Chen,H.H., Chen,R.H. and Wu,K.P.<br>Non-catalytic UBL2 domain directs deubiquitinase USP11 toward K48-linked polyubiquitin chains<br>J Biol Chem (2025) 301, 110924-110924. PubMed  Europe PubMed DOI
  10. Liu,J.X., Zhang,Y.K., Zhan,W., Xie,J.H., Xu,Q.H., Zhang,J. and Tai,X.<br>USP11 promotes autophagy to attenuate LPS-induced oxidative stress in lung epithelial cells by stabilizing FOXO1 levels<br>Biochem Biophys Res Commun (2025) 751, 151368-151368. PubMed  Europe PubMed DOI
  11. Rajkumar,S., Jung,J.H., Kim,J.Y., Karapurkar,J.K., Birappa,G., Gowda,D.A.A., Ajaykumar,C.B., Perumalsamy,H., Suresh,B., Kim,K.S., Hong,S.H. and Ramakrishna,S.<br>Loss of Ubiquitin-Specific Protease 11 Mitigates Pulmonary Fibrosis in Human Pluripotent Stem Cell-Derived Alveolar Organoids<br>Int J Stem Cells (2025) PubMed  Europe PubMed DOI
  12. Sheng,J., Wu,D., Shang,J., Fu,X., Gao,H., Rong,J., Wang,J., Hu,J. and Qi,X.<br>Usp11 maintained the survival of marginal zone B cells under ionizing radiation by deubiquitinating DLL1 and JAG2<br>Cell Death Dis (2025) 16, 67-67. PubMed  Europe PubMed DOI  PMC  EPMC
  13. Shin,J.H., Kim,J.Y., Kim,S.H., Kang,Y., Lee,H.J., Kim,M.J., Choi,J., Jeong,S.K., Park,S.O., Cho,Y.B., Kim,K.K., Shim,J.H., Chun,E. and Lee,K.Y.<br>USP11 promotes colorectal cancer progression by stabilizing EGFR and TRAF6: a potential therapeutic target in EGFR- and TLR-driven tumorigenesis<br>Cell Death Dis (2025) 16, 894-894. PubMed  Europe PubMed DOI  PMC  EPMC
  14. Turi da Fonte Dias,A.R. and Hoffmann,I.<br>The E3 ubiquitin ligase SPRYD3-MYCBP2(PAM) regulates mitotic cell fate and ubiquitination of USP11 to control spindle assembly<br>J Biol Chem (2025) , 110785-110785. PubMed  Europe PubMed DOI
  15. Wang,L., Tang,W., Jiang,L., Zhang,D., Wang,Z., Guo,R., Wang,J. and Xiao,D.<br>Inhibition of USP11 attenuates sepsis-associated acute kidney injury by downregulating TGFBR2/Smad3 signaling<br>Front Mol Biosci (2025) 12, 1571593-1571593. PubMed  Europe PubMed DOI  PMC  EPMC
  16. Wang,X., Xie,X., Ni,J.Y., Li,J.Y., Sun,X.A., Xie,H.Y., Yang,N.H., Guo,H.J., Lu,L., Ning,M., Zhou,L., Liu,J., Xu,C., Zhang,W., Wen,Y., Shen,Q., Xu,H. and Lu,L.M.<br>USP11 promotes renal tubular cell pyroptosis and fibrosis in UUO mice via inhibiting KLF4 ubiquitin degradation<br>Acta Pharmacol Sin (2025) 46, 159-170. PubMed  Europe PubMed DOI
  17. Yonezawa,T., Rutter,J., Ramabadran,R., Sundaramurthy,V., Datar,G., Slabicki,M. and Goodell,M.A.<br>DNMT3A Stability Is Maintained by Ubiquitin-Specific Peptidase 11 (USP11) and Sumoylation Countering Degradation<br>bioRxiv (2025) PubMed  Europe PubMed DOI  PMC  EPMC
  18. Zhang,J., Allen,J., Ward,S.J., Dekker,L.V. and Dreveny,I.<br>A versatile fluorescence polarization based deubiquitination assay using an isopeptide bond substrate mimetic (IsoMim)<br>J Biol Chem (2025) , 110342-110342. PubMed  Europe PubMed DOI  I
  19. Zhang,T., Liu,Y., Liu,F., Guo,K., Tang,R., Ye,J., Xue,L., Su,Z. and Wu,Z.B.<br>X-linked ubiquitin-specific peptidase 11 (USP11) increases susceptibility to Cushing's disease in women<br>Acta Neuropathol Commun (2025) 13, 22-22. PubMed  Europe PubMed DOI  PMC  EPMC  K
    20. 2024
  20. Chen,J., Ning,D., Du,P., Liu,Q., Mo,J., Liang,H., Zhang,W., Zhang,M., Jiang,L., Zhang,B. and Chen,X.<br>USP11 potentiates HGF/AKT signaling and drives metastasis in hepatocellular carcinoma<br>Oncogene (2024) 43, 123-135. PubMed  Europe PubMed DOI
  21. Cui,L., Yang,L., Lai,B., Luo,L., Deng,H., Chen,Z. and Wang,Z.<br>Integrative and comprehensive pan-cancer analysis of ubiquitin specific peptidase 11 (USP11) as a prognostic and immunological biomarker<br>Heliyon (2024) 10, e34523-e34523. PubMed  Europe PubMed DOI  PMC  EPMC
  22. Ebina,M., Miura,Y. and Sakane,F.<br>Ubiquitin-specific peptidase 11 selectively interacts with and deubiquitination-dependently stabilizes diacylglycerol kinase delta to maintain cellular glucose uptake<br>Biochim Biophys Acta Mol Cell Res (2024) 1872, 119883-119883. PubMed  Europe PubMed DOI  K
  23. Ge,C., Huang,M., Han,Y., Shou,C., Li,D. and Zhang,Y.<br>Demethyleneberberine Alleviates Pulmonary Fibrosis through Disruption of USP11 Deubiquitinating GREM1<br>Pharmaceuticals (Basel) (2024) 17 PubMed  Europe PubMed DOI  PMC  EPMC
  24. Guo,Y., Cai,C., Zhang,B., Tan,B., Tang,Q., Lei,Z., Qi,X., Chen,J., Zheng,X., Zi,D., Li,S. and Tan,J.<br>Targeting USP11 regulation by a novel lithium-organic coordination compound improves neuropathologies and cognitive functions in Alzheimer transgenic mice<br>EMBO Mol Med (2024) 16, 2856-2881. PubMed  Europe PubMed DOI
  25. Kim,W.J., Basit,A. and Lee,J.H.<br>USP11 modulates mitotic progression and senescence by regulating the p53-p21 axis through MDM2 deubiquitination<br>Biochem Biophys Res Commun (2024) 726, 150275-150275. PubMed  Europe PubMed DOI
  26. Li,T., Huang,J., Zeng,A., Yu,N. and Long,X.<br>Ubiquitin-specific peptidase 11 promotes development of keloid derived fibroblasts by de-ubiquitinating TGF-beta receptorII<br>Burns (2024) 50, 641-652. PubMed  Europe PubMed DOI  K
  27. Liu,Y., Li,D., Zhang,X., Xia,S., Qu,Y., Ling,X., Li,Y., Kong,X., Zhang,L., Cui,C.P. and Li,D.<br>A protein sequence-based deep transfer learning framework for identifying human proteome-wide deubiquitinase-substrate interactions<br>Nat Commun (2024) 15, 4519-4519. PubMed  Europe PubMed DOI  PMC  EPMC
  28. Qian,T., Bai,F., Zhang,S., Xu,Y., Wang,Y., Yuan,S., Liu,X., Du,Y., Peng,B., Zhu,W.G., Xu,X. and Pei,X.H.<br>USP11 deubiquitinates E-cadherin and maintains luminal fate of mammary tumor cells to suppress breast cancer<br>J Biol Chem (2024) , 107768-107768. PubMed  Europe PubMed DOI
  29. Qiao,L., Hu,W., Li,L., Chen,X., Liu,L. and Wang,J.<br>USP11 promotes glycolysis by regulating HIF-1alpha stability in hepatocellular carcinoma<br>J Cell Mol Med (2024) 28, e18017-e18017. PubMed  Europe PubMed DOI  PMC  EPMC
  30. Ryu,E., Yoo,J., Kang,M.S., Ha,N.Y., Jang,Y., Kim,J., Kim,Y., Kim,B.G., Kim,S., Myung,K. and Kang,S.<br>ATAD5 functions as a regulatory platform for Ub-PCNA deubiquitination<br>Proc Natl Acad Sci U S A (2024) 121, e2315759121-e2315759121. PubMed  Europe PubMed DOI
  31. Tang,Y., Wang,T., Gu,L., Xu,Y., Yang,Z., Zhu,W., Zhang,Q., Luo,J., Cao,J. and Jiao,Y.<br>USP11 Exacerbates Radiation-Induced Pneumonitis by Activating Endothelial Cell Inflammatory Response via OTUD5-STING Signaling<br>Int J Radiat Oncol Biol Phys (2024) 119, 1261-1274. PubMed  Europe PubMed DOI  I
  32. Xu,Y., Zeng,J., Liu,K., Li,D., Huang,S., Fu,S., Ye,M., Tao,S. and Wu,J.<br>USP11 promotes lipogenesis and tumorigenesis by regulating SREBF1 stability in hepatocellular carcinoma<br>Cell Commun Signal (2024) 22, 550-550. PubMed  Europe PubMed DOI  PMC  EPMC  K
  33. Zhang,N., Wang,Q., Lu,Y., Wang,F. and He,Z.<br>The deubiquitinating enzyme USP11 regulates breast cancer progression by stabilizing PGAM5<br>Breast Cancer Res (2024) 26, 135-135. PubMed  Europe PubMed DOI  PMC  EPMC  K
    34. 2023
  34. Boehm,D., Lam,V., Schnolzer,M. and Ott,M.<br>The lysine methyltransferase SMYD5 amplifies HIV-1 transcription and is post-transcriptionally upregulated by Tat and USP11<br>Cell Rep (2023) 42, 112234-112234. PubMed  Europe PubMed DOI  PMC  EPMC  K
  35. Deng,T., Xie,L., Xiaofang,C., Zhang,Z., Xiao,Y., Peng,Y., Yin,L., Fu,Y. and Li,X.<br>ATM-Mediated translocation of RanBPM regulates DNA damage response by stabilizing p21 in non-small cell lung cancer cells<br>Cell Oncol (Dordr) (2023) PubMed  Europe PubMed DOI
  36. Duan,J., Huang,D., Liu,C., Lv,Y., Zhang,L., Chang,F., Zeng,X., Li,L., Wang,W. and Shao,G.<br>USP11-mediated LSH deubiquitination inhibits ferroptosis in colorectal cancer through epigenetic activation of CYP24A1<br>Cell Death Dis (2023) 14, 402-402. PubMed  Europe PubMed DOI  PMC  EPMC
  37. Fang,Y., Zhao,T., Ni,H., Li,Y., Zhu,Y., Gao,R., Zhang,L., Jia,Z. and Chen,G.<br>USP11 exacerbates neuronal apoptosis after traumatic brain injury via PKM2-mediated PI3K/AKT signaling pathway<br>Brain Res (2023) 1807, 148321-148321. PubMed  Europe PubMed DOI
  38. Ghoreshi,Z.A., Molaei,H.R. and Arefinia,N.<br>The Role of DNA Viruses in Human Cancer<br>Cancer Inform (2023) 22, 11769351231154186-11769351231154186. PubMed  Europe PubMed DOI  PMC  EPMC  V
  39. Maurer,S.K., Mayer,M.P., Ward,S.J., Boudjema,S., Halawa,M., Zhang,J., Caulton,S.G., Emsley,J. and Dreveny,I.<br>Ubiquitin-specific protease 11 structure in complex with an engineered substrate mimetic reveals a molecular feature for deubiquitination selectivity<br>J Biol Chem (2023) 299, 105300-105300. PubMed  Europe PubMed DOI  PMC  EPMC
  40. Shi,Y., Tao,M., Chen,H., Ma,X., Wang,Y., Hu,Y., Zhou,X., Li,J., Cui,B., Qiu,A., Zhuang,S. and Liu,N.<br>Ubiquitin-specific protease 11 promotes partial epithelial-to-mesenchymal transition by deubiquitinating the epidermal growth factor receptor during kidney fibrosis<br>Kidney Int (2023) 103, 544-564. PubMed  Europe PubMed DOI
  41. Zhang,Y., Hailati,J., Ma,X., Midilibieke,H. and Liu,Z.<br>Ubiquitin-specific protease 11 Aggravates Ischemia-reperfusion-induced Cardiomyocyte Pyroptosis and Injury by Promoting TRAF3 Deubiquitination<br>Balkan Med J (2023) 40, 205-214. PubMed  Europe PubMed DOI  PMC  EPMC  K
  42. Zhu,J., Sun,R., Sun,K., Yan,C., Jiang,J., Kong,F. and Shi,J.<br>The deubiquitinase USP11 ameliorates intervertebral disc degeneration by regulating oxidative stress-induced ferroptosis via deubiquitinating and stabilizing Sirt3<br>Redox Biol (2023) 62, 102707-102707. PubMed  Europe PubMed DOI  PMC  EPMC
    43. 2022
  43. Gao,Y., Chen,B., Wang,R., Xu,A., Wu,L., Lu,H. and Zhao,G.<br>Knockdown of RRM1 in tumor cells promotes radio-/chemotherapy induced ferroptosis by regulating p53 ubiquitination and p21-GPX4 signaling axis<br>Cell Death Discov (2022) 8, 343-343. PubMed  Europe PubMed DOI  PMC  EPMC
  44. Guo,T., Tang,H., Yuan,Z., Zhang,E. and Wang,X.<br>The Dual Role of USP11 in Cancer<br>J Oncol (2022) 2022, 9963905-9963905. PubMed  Europe PubMed DOI  PMC  EPMC  V
  45. Kaushal,K., Tyagi,A., Karapurkar,J.K., Kim,E.J., Tanguturi,P., Kim,K.S., Jung,H.S. and Ramakrishna,S.<br>Genome-Wide CRISPR/Cas9-Based Screening for Deubiquitinase Subfamily Identifies Ubiquitin-Specific Protease 11 as a Novel Regulator of Osteogenic Differentiation<br>Int J Mol Sci (2022) 23 PubMed  Europe PubMed DOI  PMC  EPMC
  46. Li,L., Deng,T., Zhang,L., Wang,Y., Zhou,Y., Liu,Y., Li,H., Dai,J., Yang,Y., Ling,N., Liu,H., Liu,J., Cao,L., Xu,M. and Ye,M.<br>ERK-mediated Cytoplasmic Retention of USP11 Contributes to Breast Cancer Cell Proliferation by Stabilizing Cytoplasmic p21<br>Int J Biol Sci (2022) 18, 2568-2582. PubMed  Europe PubMed DOI  PMC  EPMC
  47. Ni,J.Y., Wang,X., Xie,H.Y., Yang,N.H., Li,J.Y., Sun,X.A., Guo,H.J., Zhou,L., Zhang,W., Liu,J. and Lu,L.M.<br>Deubiquitinating enzyme USP11 promotes renal tubular cell senescence and fibrosis via inhibiting the ubiquitin degradation of TGF-beta receptor II<br>Acta Pharmacol Sin (2022) PubMed  Europe PubMed DOI  K
  48. Paul,B.D.<br>DUB'ling down uncovers an X-linked vulnerability in Alzheimer's disease<br>Cell (2022) 185, 3854-3856. PubMed  Europe PubMed DOI
  49. Zhang,W., Li,X., Xu,J., Wang,Y., Xing,Z., Hu,S., Fan,Q., Lu,S., Cheng,J., Gu,J. and Cai,R.<br>The RSL3 Induction of KLK Lung Adenocarcinoma Cell Ferroptosis by Inhibition of USP11 Activity and the NRF2-GSH Axis<br>Cancers (Basel) (2022) 14 PubMed  Europe PubMed DOI  PMC  EPMC
    50. 2021
  50. Basic,M., Hertel,A., Bajdzienko,J., Bonn,F., Tellechea,M., Stolz,A., Kern,A., Behl,C. and Bremm,A.<br>The deubiquitinase USP11 is a versatile and conserved regulator of autophagy<br>J Biol Chem (2021) 297, 101263-101263. PubMed  Europe PubMed DOI  PMC  EPMC
  51. Jurga,M., Abugable,A.A., Goldman,A.S.H. and El-Khamisy,S.F.<br>USP11 controls R-loops by regulating senataxin proteostasis<br>Nat Commun (2021) 12, 5156-5156. PubMed  Europe PubMed DOI  PMC  EPMC
  52. Liu,H., Liu,M., He,B. and Li,Q.<br>Inhibition of USP11 sensitizes gastric cancer to chemotherapy via suppressing RhoA and Ras-mediated signaling pathways<br>Clin Res Hepatol Gastroenterol (2021) , 101779-101779. PubMed  Europe PubMed DOI  K
  53. Meng,C., Zhan,J., Chen,D., Shao,G., Zhang,H., Gu,W. and Luo,J.<br>The deubiquitinase USP11 regulates cell proliferation and ferroptotic cell death via stabilization of NRF2 USP11 deubiquitinates and stabilizes NRF2<br>Oncogene (2021) PubMed  Europe PubMed DOI
  54. Perry,M., Biegert,M., Kollala,S.S., Mallard,H., Su,G., Kodavati,M., Kreiling,N., Holbrook,A. and Ghosal,G.<br>USP11 mediates repair of DNA-protein crosslinks by deubiquitinating SPRTN metalloprotease<br>J Biol Chem (2021) , 100396-100396. PubMed  Europe PubMed DOI
  55. Qiao,L., Zhang,Q., Sun,Z., Liu,Q., Wu,Z., Hu,W., Bao,S., Yang,Q. and Liu,L.<br>The E2F1/USP11 positive feedback loop promotes hepatocellular carcinoma metastasis and inhibits autophagy by activating ERK/mTOR pathway<br>Cancer Lett (2021) 514, 63-78. PubMed  Europe PubMed DOI
  56. Rong,Y., Fan,J., Ji,C., Wang,Z., Ge,X., Wang,J., Ye,W., Yin,G., Cai,W. and Liu,W.<br>USP11 regulates autophagy-dependent ferroptosis after spinal cord ischemia-reperfusion injury by deubiquitinating Beclin 1<br>Cell Death Differ (2021) PubMed  Europe PubMed DOI
  57. Sun,H., Wang,R., Liu,Y., Mei,H., Liu,X. and Peng,Z.<br>USP11 induce resistance to 5-Fluorouracil in Colorectal Cancer through activating autophagy by stabilizing VCP<br>J Cancer (2021) 12, 2317-2325. PubMed  Europe PubMed DOI  PMC  EPMC
  58. Tang,Y., Yuan,Q., Zhao,C., Xu,Y., Zhang,Q., Wang,L., Sun,Z., Cao,J., Luo,J. and Jiao,Y.<br>Targeting USP11 may alleviate radiation-induced pulmonary fibrosis by regulating endothelium tight junction<br>Int J Radiat Biol (2021) , 1-11. PubMed  Europe PubMed DOI
  59. Yang,H., Park,D., Ryu,J. and Park,T.<br>USP11 degrades KLF4 via its deubiquitinase activity in liver diseases<br>J Cell Mol Med (2021) 25, 6976-6987. PubMed  Europe PubMed DOI
  60. Zhang,W., Wang,Z., Cai,G. and Huang,P.<br>Circ_DOCK1 regulates USP11 through miR-132-3p to control colorectal cancer progression<br>World J Surg Oncol (2021) 19, 67-67. PubMed  Europe PubMed DOI  PMC  EPMC
  61. Zhang,X., Liu,T., Xu,S., Gao,P., Dong,W., Liu,W., Gao,M., Song,L., Cui,L. and Dong,X.<br>A pro-inflammatory mediator USP11 enhances the stability of p53 and inhibits KLF2 in intracerebral hemorrhage<br>Mol Ther Methods Clin Dev (2021) 21, 681-692. PubMed  Europe PubMed DOI  PMC  EPMC  K
    62. 2020
  62. Bai,M., Che,Y., Lu,K. and Fu,L.<br>Analysis of deubiquitinase OTUD5 as a biomarker and therapeutic target for cervical cancer by bioinformatic analysis<br>PeerJ (2020) 8, e9146-e9146. PubMed  Europe PubMed DOI  PMC  EPMC
  63. Feng,P., Li,L., Dai,J., Zhou,L., Liu,J., Zhao,J., Li,X., Ling,N., Qiu,S., Zhang,L., Xie,T., Chen,Y., Donovan,M.J., Peng,T., Song,J. and Ye,M.<br>The regulation of NONO by USP11 via deubiquitination is linked to the proliferation of melanoma cells<br>J Cell Mol Med (2020) PubMed  Europe PubMed DOI  K
  64. Huang,D., Liu,C., Sun,X., Sun,X., Qu,Y., Tang,Y., Li,G. and Tong,T.<br>CRL4(DCAF8) and USP11 oppositely regulate the stability of myeloid leukemia factors (MLFs)<br>Biochem Biophys Res Commun (2020) 529, 127-132. PubMed  Europe PubMed DOI
    65. 2019
  65. Istomine,R., Alvarez,F., Almadani,Y., Philip,A. and Piccirillo,C.A.<br>The deubiquitinating enzyme ubiquitin-specific peptidase 11 potentiates TGF-beta signaling in CD4(+) T Cells to facilitate Foxp3(+) regulatory T and TH17 cell differentiation<br>J Immunol (2019) 203, 2388-2400. PubMed  Europe PubMed DOI
  66. Maupin-Furlow,J.A.<br>Putting phage to work in deubiquitinase ligand discovery<br>J Biol Chem (2019) 294, 437-438. PubMed  Europe PubMed DOI  PMC  EPMC
  67. Spiliotopoulos,A., Blokpoel Ferreras,L., Densham,R.M., Caulton,S.G., Maddison,B.C., Morris,J.R., Dixon,J.E., Gough,K.C. and Dreveny,I.<br>Discovery of peptide ligands targeting a specific ubiquitin-like domain-binding site in the deubiquitinase USP11<br>J Biol Chem (2019) 294, 424-436. PubMed  Europe PubMed DOI
  68. Sun,H., Ou,B., Zhao,S., Liu,X., Song,L., Liu,X., Wang,R. and Peng,Z.<br>USP11 promotes growth and metastasis of colorectal cancer via PPP1CA-mediated activation of ERK/MAPK signaling pathway<br>EBioMedicine (2019) 48, 236-247. PubMed  Europe PubMed DOI
  69. Ting,X., Xia,L., Yang,J., He,L., Si,W., Shang,Y. and Sun,L.<br>USP11 acts as a histone deubiquitinase functioning in chromatin reorganization during DNA repair<br>Nucleic Acids Res (2019) 47, 9721-9740. PubMed  Europe PubMed DOI
  70. Wang,W., Wang,J., Yan,H., Zhang,K. and Liu,Y.<br>Upregulation of USP11 promotes epithelial to mesenchymal transition by deubiquitinating Snail in ovarian cancer<br>Oncol Rep (2019) 41, 1739-1748. PubMed  Europe PubMed DOI
    71. 2018
  71. Stockum,A., Snijders,A.P. and Maertens,G.N.<br>USP11 deubiquitinates RAE1 and plays a key role in bipolar spindle formation<br>PLoS ONE (2018) 13, e0190513-e0190513. PubMed  Europe PubMed DOI
    72. 2017
  72. Zhou,Z., Luo,A., Shrivastava,I., He,M., Huang,Y., Bahar,I., Liu,Z. and Wan,Y.<br>Regulation of XIAP turnover reveals a role for USP11 in promotion of tumorigenesis<br>EBioMedicine (2017) 15, 48-61. PubMed  Europe PubMed DOI
    73. 2016
  73. Jacko,A.M., Nan,L., Li,S., Tan,J., Zhao,J., Kass,D.J. and Zhao,Y.<br>De-ubiquitinating enzyme, USP11, promotes transforming growth factor beta-1 signaling through stabilization of transforming growth factor beta receptor II<br>Cell Death Dis (2016) 7, e2474-e2474. PubMed  Europe PubMed DOI
  74. Lee,E.W. and Song,J.<br>USP11: a key regulator of cIAP2 stability and sensitivity to SMAC mimetics<br>Mol Cell Oncol (2016) 3, e1029829-e1029829. PubMed  Europe PubMed DOI  PMC  EPMC
  75. Lim,K.H., Suresh,B., Park,J.H., Kim,Y.S., Ramakrishna,S. and Baek,K.H.<br>Ubiquitin-specific protease 11 functions as a tumor suppressor by modulating Mgl-1 protein to regulate cancer cell growth<br>Oncotarget (2016) 7, 14441-14457. PubMed  Europe PubMed DOI
  76. Xu,Z., Li,X., Chen,J., Zhao,J., Wang,J., Ji,Y., Shen,Y., Han,L., Shi,J. and Zhang,D.<br>USP11, deubiquitinating enzyme, associated with neuronal apoptosis following intracerebral hemorrhage<br>J Mol Neurosci (2016) 58, 16-27. PubMed  Europe PubMed DOI
  77. Yu,M., Liu,K., Mao,Z., Luo,J., Gu,W. and Zhao,W.<br>USP11 is a Negative Regulator to gammaH2AX Ubiquitylation by RNF8/RNF168<br>J Biol Chem (2016) 291, 959-967. PubMed  Europe PubMed DOI
  78. Zhang,E., Shen,B., Mu,X., Qin,Y., Zhang,F., Liu,Y., Xiao,J., Zhang,P., Wang,C., Tan,M. and Fan,Y.<br>Ubiquitin-specific protease 11 (USP11) functions as a tumor suppressor through deubiquitinating and stabilizing VGLL4 protein<br>Am J Cancer Res (2016) 6, 2901-2909. PubMed  Europe PubMed  PMC  EPMC
    79. 2015
  79. Hendriks,I.A., Schimmel,J., Eifler,K., Olsen,J.V. and Vertegaal,A.C.<br>Ubiquitin-specific protease 11 (USP11) deubiquitinates hybrid small ubiquitin-like modifier (SUMO)-ubiquitin chains to counteract RING finger protein 4 (RNF4)<br>J Biol Chem (2015) 290, 15526-15537. PubMed  Europe PubMed DOI
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