Merops Switch to
Inhibitors

Peptidase

Family Clan SEARCHES BLAST
MEROPS SUBMISSIONS

Other
information

Literature for peptidase C19.001: ubiquitin-specific peptidase 5

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

(Topics flags: P Specificity, I Inhibitor, K Knockout, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Chang,Q., Mao,H., Feng,J., Rao,L., Tang,W., Zhang,Z. and Hu,Z.
    Sodium butyrate increases USP5-mediated ubiquitination degradation of GPX4 and enhances anti-cancer efficacy of anti-PD-1 antibody
    Biochem Pharmacol237, 116927-116927. PubMed  Europe PubMed DOI
  2. Eibach,Y., Kreher,S., Poetsch,M.S., Kho,A.L., Gaertner,U., Clemen,C.S., Schroder,R., Guo,K., Milting,H., Meder,B., Potente,M., Richter,M., Schneider,A., Meiners,S., Gaute,M. and Braun,T.
    The deubiquitinase USP5 prevents accumulation of protein aggregates in cardiomyocytes
    Sci Adv11, eado3852-eado3852. PubMed  Europe PubMed DOI
  3. Hong,K.S., Ryu,K.J., Kim,H., Kim,M., Park,S.H., Kim,T., Yang,J.W., Hwangbo,C., Kim,K.D., Park,Y.J. and Yoo,J.
    MSK1 promotes colorectal cancer metastasis by increasing Snail protein stability through USP5-mediated Snail deubiquitination
    Exp Mol Med PubMed  Europe PubMed DOI
  4. Jiang,S., Jiang,L., Xu,Y., Ma,Y., Deng,Y., Jiao,C., Yin,M., Qin,C., Li,J., Zhang,L. and Chen,S.
    USP5 deubiquitinates and stabilizes IMPDH2, to promote hepatocellular carcinoma progression
    Oncogene PubMed  Europe PubMed DOI
  5. Liang,L., Jia,W., Wang,J., Feng,Y., Zhu,D., Zhao,W., Xu,C., Ling,X., Lv,Q., Ai,X., Kong,L. and Ding,W.
    LRP11 facilitates lipid metabolism and malignancy in hepatocellular carcinoma by stabilizing RACK1 through USP5 regulation
    Mol Med31, 35-35. PubMed  Europe PubMed DOI  K
  6. Long,S., Ding,T., Zheng,Y., Shao,J., Liu,Y. and Wang,Q.
    USP5 motivates immunosuppressive microenvironment in multiple myeloma by activating STAT2-PFKFB4-mediated glycolysis
    Cancer Immunol Immunother74, 180-180. PubMed  Europe PubMed DOI
  7. Oak,S., Karajgikar,O., Gadewal,N., Sulkshane,P., Verma,T., Gupta,S. and Teni,T.
    The deubiquitinase inhibitor WP1130 drives nuclear aggregation and reactivation of mutant p53 for selective cancer cell targeting
    FEBS J PubMed  Europe PubMed DOI  I
  8. Qiao,Z., Li,D., Zhang,F., Zhu,J., Liu,S., Bai,X., Yao,H., Chen,Z., Yan,Y., Xu,X. and Ma,F.
    USP5 inhibits anti-RNA viral innate immunity by deconjugating K48-linked unanchored and K63-linked anchored ubiquitin on IRF3
    PLoS Pathog21, e1012843-e1012843. PubMed  Europe PubMed DOI
  9. Shao,N., Xi,L., Lv,Y., Idris,M., Zhang,L., Cao,Y., Xiang,J., Xu,X., Ong,B.X., Zhang,Q., Peng,X., Yue,X., Xu,F. and Liu,C.
    USP5 stabilizes YTHDF1 to control cancer immune surveillance through mTORC1-mediated phosphorylation
    Nat Commun16, 1313-1313. PubMed  Europe PubMed DOI
  10. Tang,J.Y., Peng,Y.X., Zhu,W., Qiu,J.Y., Huang,W., Yi,H., Lu,S.S., Feng,J., Yu,Z.Z., Wu,D., Wen,Q., Yuan,L., Peng,J. and Xiao,Z.Q.
    USP5 Binds and Stabilizes EphA2 to Increase Nasopharyngeal Carcinoma Radioresistance
    Int J Biol Sci21, 893-909. PubMed  Europe PubMed DOI
  11. Xiong,N., Wang,Y. and Jiang,J.
    USP5 Promotes Head and Neck Squamous Cell Carcinoma Progression via mTOR Signaling Pathway
    Cancer Med14, e70752-e70752. PubMed  Europe PubMed DOI  K
  12. Yang,Z., Yu,Z., Teng,J., Yanzhang,R., Yu,Y., Zhang,H., Jin,G. and Wang,F.
    PDK1-mediated phosphorylation of USP5 modulates NF-kappaB signalling to enhance osteosarcoma growth
    Int J Biol Macromol306, 141378-141378. PubMed  Europe PubMed DOI
  13. Yao,L., Lai,Y., Li,H., Chen,S., Yu,X., Zhou,N. and Lang,D.
    USP5 Deletion Inhibits KD Serum Induced-Human Coronary Artery Endothelial Cell Dysfunction by Regulating the NFATC1/TLR4-Mediated NF-kappaB Signaling Pathway in Kawasaki Disease
    Inflammation PubMed  Europe PubMed DOI
  14. Zhang,Y., Zhu,W., Tao,R., Li,W., Jiang,C. and Yan,X.
    Endogenous peptide CBDP1 inhibits clear cell renal cell carcinoma progression by targeting USP5/YTHDF2/TRPM5 axis
    J Transl Med23, 116-116. PubMed  Europe PubMed DOI
  15. [YEAR:1-10-2024]
    RETRACTION: MiR-125a Suppresses Malignancy of Multiple Myeloma by Reducing the Deubiquitinase USP5
    J Cell Biochem125, e30628-e30628. PubMed  Europe PubMed DOI
    16. 2024
  16. Cai,H., Ke,Z.B., Chen,J.Y., Li,X.D., Zhu,J.M., Xue,Y.T., Ruan,Z.T., Wang,Z., Lin,F., Zheng,Q.S., Wei,Y., Xue,X.Y. and Xu,N.
    Ubiquitin-specific protease 5 promotes bladder cancer progression through stabilizing Twist1
    Oncogene43, 703-713. PubMed  Europe PubMed DOI
  17. Capuano,A., D'Urso,G., Aliberti,M., Ruggiero,D., Terracciano,S., Festa,C., Tosco,A., Chini,M.G., Lauro,G., Bifulco,G. and Casapullo,A.
    Chemoproteomics Reveals USP5 (Ubiquitin Carboxyl-Terminal Hydrolase 5) as Promising Target of the Marine Polyketide Gracilioether A
    Mar Drugs22, PubMed  Europe PubMed DOI
  18. Gao,S.T., Xin,X., Wang,Z.Y., Hu,Y.Y. and Feng,Q.
    USP5: Comprehensive insights into structure, function, biological and disease-related implications, and emerging therapeutic opportunities
    Mol Cell Probes73, 101944-101944. PubMed  Europe PubMed DOI  V
  19. Gu,J., Chen,C., He,P., Du,Y. and Zhu,B.
    Unraveling the Immune Regulatory Functions of USP5: Implications for Disease Therapy
    Biomolecules14, PubMed  Europe PubMed DOI  V
  20. Guo,H., Liu,R., Lv,H., Huo,Q., Yao,Y. and Lu,X.
    USP5 facilitates diabetic retinopathy development by stabilizing ROBO4 via deubiquitination
    Cell Signal120, 111225-111225. PubMed  Europe PubMed DOI  K
  21. Jiang,X., You,H., Niu,Y., Ding,Y., Chen,Z., Wang,H., Xu,Y., Zhou,P., Wei,L., Deng,D., Xue,L., Peng,Y., Yang,Y., Fan,L. and Shao,N.
    E2F1-regulated USP5 contributes to the tumorigenic capacity of glioma stem cells through the maintenance of OCT4 stability
    Cancer Lett216875-216875. PubMed  Europe PubMed DOI
  22. Li,Y., Qiu,G., Zhou,M., Chen,Q. and Liao,X.
    USP5 Stabilizes IKBKG Through Deubiquitination to Suppress Ferroptosis and Promote Growth in Non-small Cell Lung Cancer
    Cell Biochem Biophys PubMed  Europe PubMed DOI
  23. Lu,R., Jin,Y. and Zheng,M.
    USP5-dependent HDAC1 promotes cisplatin resistance and the malignant progression of non-small cell lung cancer by regulating RILP acetylation levels
    Thorac Cancer PubMed  Europe PubMed DOI
  24. Ning,F., Du,L., Li,J., Wu,T., Zhou,J., Chen,Z., Hu,X., Zhang,Y., Luan,X., Xin,H., Yuan,C. and Zhang,X.
    The deubiquitinase USP5 promotes cholangiocarcinoma progression by stabilizing YBX1
    Life Sci348, 122674-122674. PubMed  Europe PubMed DOI
  25. Olie,C.S., O'Brien,D.P., Jones,H.B.L., Liang,Z., Damianou,A., Sur-Erdem,I., Pinto-Fernandez,A., Raz,V. and Kessler,B.M.
    Deubiquitinases in muscle physiology and disorders
    Biochem Soc Trans52, 1085-1098. PubMed  Europe PubMed DOI  V
  26. Peng,Z.M., Han,X.J., Wang,T., Li,J.J., Yang,C.X., Tou,F.F. and Zhang,Z.
    PFKP deubiquitination and stabilization by USP5 activate aerobic glycolysis to promote triple-negative breast cancer progression
    Breast Cancer Res26, 10-10. PubMed  Europe PubMed DOI
  27. Song,J., Liu,L., Wang,F. and Bao,D.
    Targeting Ubiquitin-specific Protease 5 Overcomes Chemoresistance via Negatively Regulating p53 in Gastric Cancer
    Curr Mol Med PubMed  Europe PubMed DOI  K
  28. Sun,H., Cui,Z., Li,C., Gao,Z., Xu,J., Bian,Y., Gu,T., Zhang,J., Li,T., Zhou,Q., Yang,D., He,Z., Li,B., Li,F., Xu,Z. and Xu,H.
    USP5 Promotes Ripretinib Resistance in Gastrointestinal Stromal Tumors by MDH2 Deubiquition
    Adv Sci (Weinh)e2401171-e2401171. PubMed  Europe PubMed DOI
  29. Sun,W., Lu,H., Ma,L., Ding,C., Wang,H. and Chu,Y.
    Deubiquitinase USP5 regulates RIPK1 driven pyroptosis in response to myocardial ischemic reperfusion injury
    Cell Commun Signal22, 466-466. PubMed  Europe PubMed DOI
  30. Tian,Y., Chen,W.M. and Zhang,Y.
    [Clinical Significance of USP5 Expression Level in Acute Myeloid Leukemia and Its Regulatory Effects on AKT/mTOR/4EBP1 Signaling Pathway]
    Zhongguo Shi Yan Xue Ye Xue Za Zhi32, 670-678. PubMed  Europe PubMed DOI  K
  31. Wan,Q.K., Li,T.T., Liu,B.B. and He,B.
    USP5 promotes tumor progression by stabilizing SLUG in bladder cancer
    Oncol Lett28, 572-572. PubMed  Europe PubMed DOI  K
  32. Wang,J., Fang,S., Jiang,Y. and Hua,Q.
    Unraveling the Mechanism of Action of Ubiquitin-Specific Protease 5 and Its Inhibitors in Tumors
    Clin Med Insights Oncol18, 11795549241281932-11795549241281932. PubMed  Europe PubMed DOI
  33. Wang,T., Tong,J., Zhang,X., Wang,Z., Xu,L., Pan,P. and Hou,T.
    Structure-based virtual screening of novel USP5 inhibitors targeting the zinc finger ubiquitin-binding domain
    Comput Biol Med174, 108397-108397. PubMed  Europe PubMed DOI
  34. Wu,Q., Liu,R., Yang,Y., Peng,J., Huang,J., Li,Z., Huang,K. and Zhu,X.
    USP5 promotes tumorigenesis by activating Hedgehog/Gli1 signaling pathway in osteosarcoma
    Am J Cancer Res14, 1204-1216. PubMed  Europe PubMed DOI
  35. Zhang,H.H., Zhang,A.Q., Peng,P., Huang,L., Liu,C.Y., Nie,X.R., Hou,D.F., Zhang,X. and Li,S.Z.
    USP5 facilitates bladder cancer progression by stabilizing the c-Jun protein
    Cancer Cell Int24, 32-32. PubMed  Europe PubMed DOI
    36. 2023
  36. Cao,L., Liu,H., Huang,C., Guo,C., Zhao,L., Gao,C., Xu,Y., Wang,G., Liang,N. and Li,S.
    USP5 knockdown alleviates lung cancer progression via activating PARP1-mediated mTOR signaling pathway
    Biol Direct18, 16-16. PubMed  Europe PubMed DOI
  37. Shi,S., Pan,X., Chen,M., Zhang,L., Zhang,S., Wang,X., Shi,S., Chen,Z., Lin,W. and Jiang,Y.
    USP5 promotes lipopolysaccharide-induced apoptosis and inflammatory response by stabilizing the TXNIP protein
    Hepatol Commun7, PubMed  Europe PubMed DOI  K
  38. Tung,C.H., Wu,J.E., Huang,M.F., Wang,W.L., Wu,Y.Y., Tsai,Y.T., Hsu,X.R., Lin,S.H., Chen,Y.L. and Hong,T.M.
    Ubiquitin-specific peptidase 5 facilitates cancer stem cell-like properties in lung cancer by deubiquitinating beta-catenin
    Cancer Cell Int23, 207-207. PubMed  Europe PubMed DOI
  39. Wang,Q., Chen,F., Yang,N., Xu,L., Yu,X., Wu,M. and Zhou,Y.
    DEPDC1B-mediated USP5 deubiquitination of beta-catenin promotes breast cancer metastasis by activating the wnt/beta-catenin pathway
    Am J Physiol Cell Physiol325, C833-C833. PubMed  Europe PubMed DOI
  40. Xia,P., Zhang,H., Lu,H., Xu,K., Jiang,X., Jiang,Y., Gongye,X., Chen,Z., Liu,J., Chen,X., Ma,W., Zhang,Z. and Yuan,Y.
    METTL5 stabilizes c-Myc by facilitating USP5 translation to reprogram glucose metabolism and promote hepatocellular carcinoma progression
    Cancer Commun (Lond)43, 338-364. PubMed  Europe PubMed DOI
  41. Yan,B., Guo,J., Deng,S., Chen,D. and Huang,M.
    A pan-cancer analysis of the role of USP5 in human cancers
    Sci Rep13, 8972-8972. PubMed  Europe PubMed DOI
    42. 2022
  42. Bailly,C.
    Anti-inflammatory and anticancer p-terphenyl derivatives from fungi of the genus Thelephora
    Bioorg Med Chem70, 116935-116935. PubMed  Europe PubMed DOI  V  I
  43. Hill,J. and Nyathi,Y.
    USP5 enhances SGTA mediated protein quality control
    PLoS ONE17, e0257786-e0257786. PubMed  Europe PubMed DOI  K
  44. Huang,W., Liu,X., Zhang,Y., Deng,M., Li,G., Chen,G., Yu,L., Jin,L., Liu,T., Wang,Y. and Chen,Y.
    USP5 promotes breast cancer cell proliferation and metastasis by stabilizing HIF2alpha
    J Cell Physiol237, 2211-2219. PubMed  Europe PubMed DOI
  45. Pahi,Z.G., Kovacs,L., Szucs,D., Borsos,B.N., Deak,P. and Pankotai,T.
    Usp5, Usp34, and Otu1 deubiquitylases mediate DNA repair in Drosophila melanogaster
    Sci Rep12, 5870-5870. PubMed  Europe PubMed DOI  K
    46. 2021
  46. Cai,B., Zhao,J., Zhang,Y., Liu,Y., Ma,C., Yi,F., Zheng,Y., Zhang,L., Chen,T., Liu,H., Liu,B. and Gao,C.
    USP5 attenuates NLRP3 inflammasome activation by promoting autophagic degradation of NLRP3
    Autophagy1-15. PubMed  Europe PubMed DOI
  47. Cheung,B.B., Kleynhans,A., Mittra,R., Kim,P.Y., Holien,J.K., Nagy,Z., Ciampa,O.C., Seneviratne,J.A., Mayoh,C., Raipuria,M., Gadde,S., Massudi,H., Wong,I.P.L., Tan,O., Gong,A., Suryano,A., Diakiw,S.M., Liu,B., Arndt,G.M., Liu,T., Kumar,N., Sangfelt,O., Zhu,S., Norris,M.D., Haber,M., Carter,D.R., Parker,M.W. and Marshall,G.M.
    A novel combination therapy targeting ubiquitin-specific protease 5 in MYCN-driven neuroblastoma
    Oncogene PubMed  Europe PubMed DOI
  48. Li,G., Yang,T., Chen,Y., Bao,J., Wu,D., Hu,X., Feng,C., Xu,L., Li,M., Li,G., Jin,M., Xu,Y., Zhang,R., Qian,G. and Pan,J.
    USP5 Sustains the Proliferation of Glioblastoma Through Stabilization of CyclinD1
    Front Pharmacol12, 720307-720307. PubMed  Europe PubMed DOI  K
  49. Li,L., Wang,S., Wang,M., Qi,G. and Zhao,H.
    Ubiquitin-Specific Peptidase 5 is Involved in the Proliferation of Trophoblast Cells by Regulating Wnt/beta-Catenin Signaling
    Mol Biotechnol PubMed  Europe PubMed DOI
  50. Li,Y. and Zhou,J.
    USP5 Promotes Uterine Corpus Endometrial Carcinoma Cell Growth and Migration via mTOR/4EBP1 Activation
    Cancer Manag Res13, 3913-3924. PubMed  Europe PubMed DOI
  51. Mann,M.K., Zepeda-Velazquez,C.A., Gonzalez-Alvarez,H., Dong,A., Kiyota,T., Aman,A.M., Loppnau,P., Li,Y., Wilson,B., Arrowsmith,C.H., Al-Awar,R., Harding,R.J. and Schapira,M.
    Structure-Activity Relationship of USP5 Inhibitors
    J Med Chem64, 15017-15036. PubMed  Europe PubMed DOI
  52. Pan,J., Qiao,Y., Chen,C., Zang,H., Zhang,X., Qi,F., Chang,C., Yang,F., Sun,M., Lin,S., Tang,Q., Li,L., Wang,M., Wu,M., Liu,Y., Lai,C., Chen,J. and Chen,G.
    USP5 facilitates non-small cell lung cancer progression through stabilization of PD-L1
    Cell Death Dis12, 1051-1051. PubMed  Europe PubMed DOI  K
  53. Sutherland,C.J., Henrici,R.C. and Artavanis-Tsakonas,K.
    Artemisinin susceptibility in the malaria parasite Plasmodium falciparum: propellers, adaptor proteins and the need for cellular healing
    FEMS Microbiol Rev45, fuaa056-fuaa056. PubMed  Europe PubMed DOI  I
  54. Zhang,Z., Cui,Z., Xie,Z., Li,C., Xu,C., Guo,X., Yu,J., Chen,T., Facchinetti,F., Bohnenberger,H., Leong,T.L., Xie,Y., Mao,X. and Zhao,J.
    Deubiquitinase USP5 promotes non-small cell lung cancer cell proliferation by stabilizing cyclin D1
    Transl Lung Cancer Res10, 3995-4011. PubMed  Europe PubMed DOI  K
    55. 2020
  55. Lian,J., Liu,C., Guan,X., Wang,B., Yao,Y., Su,D., Ma,Y., Fang,L. and Zhang,Y.
    Ubiquitin specific peptidase 5 enhances STAT3 signaling and promotes migration and invasion in Pancreatic Cancer
    J Cancer11, 6802-6811. PubMed  Europe PubMed DOI
  56. Qian,G., Zhu,L., Huang,C., Liu,Y., Ren,Y., Ding,Y., Qian,W., Xu,Q., Zheng,H. and Lv,H.
    Ubiquitin specific protease 5 negatively regulates the IFNs-mediated antiviral activity via targeting SMURF1
    Int Immunopharmacol87, 106763-106763. PubMed  Europe PubMed DOI
  57. Sun,H.L., Zhu,A.C., Gao,Y., Terajima,H., Fei,Q., Liu,S., Zhang,L., Zhang,Z., Harada,B.T., He,Y.Y., Bissonnette,M.B., Hung,M.C. and He,C.
    Stabilization of ERK-Phosphorylated METTL3 by USP5 Increases m(6)A Methylation
    Mol Cell80, 633-647. PubMed  Europe PubMed DOI
  58. Vashistha,V., Bhardwaj,S., Yadav,B.K. and Yadav,A.K.
    Depleting deubiquitinating enzymes promotes apoptosis in glioma cell line via RNA binding proteins SF2/ASF1
    Biochem Biophys Rep24, 100846-100846. PubMed  Europe PubMed DOI  K  I
  59. Xia,L., Shi,Y., Su,J., Friedemann,T., Tao,Z., Lu,Y., Ling,Y., Lv,Y., Zhao,R., Geng,Z., Cui,X., Lu,H. and Schroder,S.
    Shufeng Jiedu, a promising herbal therapy for moderate COVID-19:Antiviral and anti-inflammatory properties, pathways of bioactive compounds, and a clinical real-world pragmatic study
    Phytomedicine153390-153390. PubMed  Europe PubMed DOI  I
  60. Xiao,M., Liu,J., Xiang,L., Zhao,K., He,D., Zeng,Q., Zhang,Q., Xie,D., Deng,M., Zhu,Y., Zhang,Y., Liu,Y., Bo,H., Liu,X., Chen,X., Gong,L., Bao,Y., Hu,Y., Cheng,Y., Deng,L., Zhu,R., Xing,X., Zhou,M., Xiong,W., Zhou,Y., Zhou,J., Li,X. and Cao,K.
    MAFG-AS1 promotes tumor progression via regulation of the HuR/PTBP1 axis in bladder urothelial carcinoma
    Clin Transl Med10, e241-e241. PubMed  Europe PubMed DOI
  61. Xue,S., Wu,W., Wang,Z., Lu,G., Sun,J., Jin,X., Xie,L., Wang,X., Tan,C., Wang,Z., Wang,W. and Ding,X.
    Corrigendum: USP5 Promotes Metastasis in Non-Small Cell Lung Cancer by Inducing Epithelial-Mesenchymal Transition via Wnt/beta-Catenin Pathway
    Front Pharmacol11, 948-948. PubMed  Europe PubMed DOI
    62. 2019
  62. Du,Y., Lin,J., Zhang,R., Yang,W., Quan,H., Zang,L., Han,Y., Li,B., Sun,H. and Wu,J.
    Ubiquitin specific peptidase 5 promotes ovarian cancer cell proliferation through deubiquitinating HDAC2
    Aging (Albany NY)11, 9778-9793. PubMed  Europe PubMed DOI
  63. Mann,M.K., Franzoni,I., de Freitas,R.F., Tempel,W., Houliston,S., Smith,L., Vedadi,M., Arrowsmith,C.H., Harding,R.J. and Schapira,M.
    Discovery of small molecule antagonists of the USP5 zinc finger ubiquitin-binding domain
    J Med Chem62, 10144-10155. PubMed  Europe PubMed DOI  I
  64. Ning,F., Xin,H., Liu,J., Lv,C., Xin,X., Wang,M., Wang,Y., Zhang,W. and Zhang,X.
    Structure and function of USP5: insight into physiological and pathophysiological roles
    Pharmacol Res104557-104557. PubMed  Europe PubMed DOI
  65. Xu,X., Huang,A., Cui,X., Han,K., Hou,X., Wang,Q., Cui,L. and Yang,Y.
    Ubiquitin specific peptidase 5 regulates colorectal cancer cell growth by stabilizing Tu translation elongation factor
    Theranostics9, 4208-4220. PubMed  Europe PubMed DOI
    66. 2018
  66. Kim,S.Y., Kwon,S.K., Lee,S.Y. and Baek,K.H.
    Ubiquitin-specific peptidase 5 and ovarian tumor deubiquitinase 6A are differentially expressed in p53+/+ and p53-/- HCT116 cells
    Int J Oncol52, 1705-1714. PubMed  Europe PubMed DOI
  67. Liu,Q., Wu,Y., Qin,Y., Hu,J., Xie,W., Qin,F.X. and Cui,J.
    Broad and diverse mechanisms used by deubiquitinase family members in regulating the type I interferon signaling pathway during antiviral responses
    Sci Adv4, eaar2824-eaar2824. PubMed  Europe PubMed DOI
    68. 2017
  68. Kaistha,B.P., Krattenmacher,A., Fredebohm,J., Schmidt,H., Behrens,D., Widder,M., Hackert,T., Strobel,O., Hoheisel,J.D., Gress,T.M. and Buchholz,M.
    The deubiquitinating enzyme USP5 promotes pancreatic cancer via modulating cell cycle regulators
    Oncotarget8, 66215-66225. PubMed  Europe PubMed DOI
  69. Wang,S., Juan,J., Zhang,Z., Du,Y., Xu,Y., Tong,J., Cao,B., Moran,M.F., Zeng,Y. and Mao,X.
    Inhibition of the deubiquitinase USP5 leads to c-Maf protein degradation and myeloma cell apoptosis
    Cell Death Dis8, e3058-e3058. PubMed  Europe PubMed DOI  I
    70. 2016
  70. Chen,Y., Li,Y., Xue,J., Gong,A., Yu,G., Zhou,A., Lin,K., Zhang,S., Zhang,N., Gottardi,C.J. and Huang,S.
    Wnt-induced deubiquitination FoxM1 ensures nucleus beta-catenin transactivation
    EMBO J35, 668-684. PubMed  Europe PubMed DOI
  71. Stemkowski,P., Garcia-Caballero,A., Gadotti,V.M., M'Dahoma,S., Huang,S., Black,S.A., Chen,L., Souza,I.A., Zhang,Z. and Zamponi,G.W.
    TRPV1 nociceptor activity initiates USP5/T-type channel-mediated plasticity
    Cell Rep17, 2901-2912. PubMed  Europe PubMed DOI
    72. 2015
  72. Gadotti,V.M., Caballero,A.G., Berger,N.D., Gladding,C.M., Chen,L., Pfeifer,T.A. and Zamponi,G.W.
    Small organic molecule disruptors of Cav3.2 - USP5 interactions reverse inflammatory and neuropathic pain
    Mol Pain11, 11-12. PubMed  Europe PubMed DOI
  73. Scott,D., Layfield,R. and Oldham,N.J.
    Structural insights into interactions between ubiquitin specific protease 5 and its polyubiquitin substrates by mass spectrometry and ion mobility spectrometry
    Protein Sci24, 1257-1263. PubMed  Europe PubMed DOI
  74. Scott,D., Layfield,R. and Oldham,N.J.
    Ion mobility-mass spectrometry reveals conformational flexibility in the deubiquitinating enzyme USP5
    Proteomics15, 2835-2841. PubMed  Europe PubMed DOI
    75. 2014
  75. Garcia-Caballero,A., Gadotti,V.M., Stemkowski,P., Weiss,N., Souza,I.A., Hodgkinson,V., Bladen,C., Chen,L., Hamid,J., Pizzoccaro,A., Deage,M., Francois,A., Bourinet,E. and Zamponi,G.W.
    The deubiquitinating enzyme USP5 modulates neuropathic and inflammatory pain by enhancing Cav3.2 channel activity
    Neuron83, 1144-1158. PubMed  Europe PubMed DOI
  76. Nakajima,S., Lan,L., Wei,L., Hsieh,C.L., Rapic-Otrin,V., Yasui,A. and Levine,A.S.
    Ubiquitin-specific protease 5 is required for the efficient repair of DNA double-strand breaks
    PLoS ONE9, e84899-e84899. PubMed  Europe PubMed DOI
  77. Potu,H., Peterson,L.F., Pal,A., Verhaegen,M., Cao,J., Talpaz,M. and Donato,N.J.
    Usp5 links suppression of p53 and FAS levels in melanoma to the BRAF pathway
    Oncotarget5, 5559-5569. PubMed  Europe PubMed  I
    78. 2013
  78. Yoshioka,Y., Ye,Y.Q., Okada,K., Taniguchi,K., Yoshida,A., Sugaya,K., Onose,J., Koshino,H., Takahashi,S., Yajima,A., Yajima,S. and Abe,N.
    Ubiquitin-specific peptidase 5, a target molecule of vialinin A, is a key molecule of TNF-alpha production in RBL-2H3 cells
    PLoS ONE8, e80931-e80931. PubMed  Europe PubMed DOI  I
    79. 2012
  79. Eletr,Z.M.
    Ubiquitin isopeptidase T
    [ISSN:978-0-12-407743-0]3, 2062-2066. DOI
  80. Iphofer,A., Kummer,A., Nimtz,M., Ritter,A., Arnold,T., Frank,R., van den Heuvel,J., Kessler,B.M., Jansch,L. and Franke,R.
    Profiling ubiquitin linkage specificities of deubiquitinating enzymes with branched ubiquitin isopeptide probes
    Chembiochem13, 1416-1420. PubMed  Europe PubMed DOI  P
  81. Issaenko,O.A. and Amerik,A.Y.
    Chalcone-based small-molecule inhibitors attenuate malignant phenotype via targeting deubiquitinating enzymes
    Cell Cycle11, 1804-1817. PubMed  Europe PubMed DOI  I
    82. 2009
  82. Dayal,S., Sparks,A., Jacob,J., Allende-Vega,N., Lane,D.P. and Saville,M.K.
    Suppression of the deubiquitinating enzyme USP5 causes the accumulation of unanchored polyubiquitin and the activation of p53
    J Biol Chem284, 5030-5041. PubMed  Europe PubMed DOI
  83. Tse,W.K., Eisenhaber,B., Ho,S.H., Ng,Q., Eisenhaber,F. and Jiang,Y.J.
    Genome-wide loss-of-function analysis of deubiquitylating enzymes for zebrafish development
    BMC Genomics10, 637-637. PubMed  Europe PubMed DOI
    84. 2008
  84. Drag,M., Mikolajczyk,J., Bekes,M., Reyes-Turcu,F.E., Ellman,J.A., Wilkinson,K.D. and Salvesen,G.S.
    Positional-scanning fluorigenic substrate libraries reveal unexpected specificity determinants of DUBs (deubiquitinating enzymes)
    Biochem J415, 367-375. PubMed  Europe PubMed DOI  P
  85. Reyes-Turcu,F.E., Shanks,J.R., Komander,D. and Wilkinson,K.D.
    Recognition of polyubiquitin isoforms by the multiple ubiquitin binding modules of isopeptidase T
    J Biol Chem283, 19581-19592. PubMed  Europe PubMed DOI
    86. 2007
  86. Catic,A., Fiebiger,E., Korbel,G.A., Blom,D., Galardy,P.J. and Ploegh,H.L.
    Screen for ISG15-crossreactive deubiquitinases
    PLoS ONE2, e679-e679. PubMed  Europe PubMed DOI
    87. 2006
  87. Reyes-Turcu,F.E., Horton,J.R., Mullally,J.E., Heroux,A., Cheng,X. and Wilkinson,K.D.
    The ubiquitin binding domain ZnF UBP recognizes the C-terminal diglycine motif of unanchored ubiquitin
    Cell124, 1197-1208. PubMed  Europe PubMed DOI
    88. 2004
  88. Hemelaar,J., Borodovsky,A., Kessler,B.M., Reverter,D., Cook,J., Kolli,N., Gan-Erdene,T., Wilkinson,K.D., Gill,G., Lima,C.D., Ploegh,H.L. and Ovaa,H.
    Specific and covalent targeting of conjugating and deconjugating enzymes of ubiquitin-like proteins
    Mol Cell Biol24, 84-95. PubMed  Europe PubMed DOI  I
  89. [YEAR:1-6-2004]Mason,D.E., Ek,J., Peters,E.C. and Harris,J.L.
    Substrate profiling of deubiquitin hydrolases with a positional scanning library and mass spectrometry
    Biochemistry43, 6535-6544. PubMed  Europe PubMed DOI
  90. Wilkinson,K.D.
    Ubiquitin isopeptidase T
    [ISSN:0-12-079610-4]2, 1239-1243.  V
    91. 2002
  91. [YEAR:19-11-2002]Gabriel,J.M., Lacombe,T., Carobbio,S., Paquet,N., Bisig,R., Cox,J.A. and Jaton,J.C.
    Zinc is required for the catalytic activity of the human deubiquitinating isopeptidase T
    Biochemistry41, 13755-13766. PubMed  Europe PubMed DOI
  92. [YEAR:20-11-2002]Lacombe,T. and Gabriel,J.M.
    Further characterization of the putative human isopeptidase T catalytic site
    FEBS Lett531, 469-474. PubMed  Europe PubMed DOI
    93. 2000
  93. [YEAR:15-8-2000]Yin,L., Krantz,B., Russell,N.S., Deshpande,S. and Wilkinson,K.D.
    Nonhydrolyzable diubiquitin analogues are inhibitors of ubiquitin conjugation and deconjugation
    Biochemistry39, 10001-10010. PubMed  Europe PubMed DOI
    94. 1996
  94. Melandri,F., Grenier,L., Plamondon,L., Huskey,W.P. and Stein,R.L.
    Kinetic studies on the inhibition of isopeptidase T by ubiquitin aldehyde
    Biochemistry35, 12893-12900. PubMed  Europe PubMed DOI  I
    95. 1995
  95. Falquet,L., Paquet,N., Frutiger,S., Hughes,G.J., Hoang-Van,K. and Jaton,J.C.
    A human de-ubiquitinating enzyme with both isopeptidase and peptidase activities in vitro
    FEBS Lett359, 73-77. PubMed  Europe PubMed DOI
  96. Falquet,L., Paquet,N., Frutiger,S., Hughes,G.J., Hoang-Van,K. and Jaton,J.C.
    cDNA cloning of a human 100 kDa de-ubiquitinating enzyme: the 100 kDa human de-ubiquitinase belongs to the ubiquitin C-terminal hydrolase family 2 (UCH2)
    FEBS Lett376, 233-237. PubMed  Europe PubMed DOI
  97. [YEAR:3-10-1995]Stein,R.L., Chen,Z. and Melandri,F.
    Kinetic studies of isopeptidase T: modulation of peptidase activity by ubiquitin
    Biochemistry34, 12616-12623. PubMed  Europe PubMed DOI
  98. Wilkinson,K.D., Tashayev,V.L., O'Connor,L.B., Larsen,C.N., Kasperek,E. and Pickart,C.M.
    Metabolism of the polyubiquitin degradation signal: structure, mechanism, and role of isopeptidase T
    Biochemistry34, 14535-14546. PubMed  Europe PubMed
    99. 1993
  99. [YEAR:25-11-1993]Papa,F.R. and Hochstrasser,M.
    The yeast DOA4 gene encodes a deubiquitinating enzyme related to a product of the human tre-2 oncogene
    Nature366, 313-319. PubMed  Europe PubMed DOI
    100. 1992
  100. Hadari,T., Warms,J.V., Rose,I.A. and Hershko,A.
    A ubiquitin C-terminal isopeptidase that acts on polyubiquitin chains. Role in protein degradation
    J Biol Chem267, 719-727. PubMed  Europe PubMed

feedback
Page created 8-September-2023

EMBL-EBI logo

© 2025 EBI
Terms of use