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Literature for peptidase C19.001: ubiquitin-specific peptidase 5

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

(Topics flags: P Specificity, I Inhibitor, K Knockout, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Chang,Q., Mao,H., Feng,J., Rao,L., Tang,W., Zhang,Z. and Hu,Z.
    Sodium butyrate increases USP5-mediated ubiquitination degradation of GPX4 and enhances anti-cancer efficacy of anti-PD-1 antibody
    Biochem Pharmacol (2025) 237, 116927-116927. PubMed  Europe PubMed DOI
  2. Chen,Y., Wang,Y., Wu,T., Guo,X., Bai,X., Wang,L., Yan,P., Zheng,Z., Xiao,L. and Li,L.
    Inhibition of USP5 Attenuates Atherosclerosis by Suppressing PDCD4-Mediated Endothelial Dysfunction: Evidence from In Vitro HUVEC and In Vivo Models
    Cardiovasc Toxicol (2025) 25, 1272-1287. PubMed  Europe PubMed DOI  K
  3. Eibach,Y., Kreher,S., Poetsch,M.S., Kho,A.L., Gaertner,U., Clemen,C.S., Schroder,R., Guo,K., Milting,H., Meder,B., Potente,M., Richter,M., Schneider,A., Meiners,S., Gaute,M. and Braun,T.
    The deubiquitinase USP5 prevents accumulation of protein aggregates in cardiomyocytes
    Sci Adv (2025) 11, eado3852-eado3852. PubMed  Europe PubMed DOI  PMC  EPMC
  4. Hong,K.S., Ryu,K.J., Kim,H., Kim,M., Park,S.H., Kim,T., Yang,J.W., Hwangbo,C., Kim,K.D., Park,Y.J. and Yoo,J.
    MSK1 promotes colorectal cancer metastasis by increasing Snail protein stability through USP5-mediated Snail deubiquitination
    Exp Mol Med (2025) PubMed  Europe PubMed DOI
  5. Hwang,C.H., Lee,M., Kim,J.W., Nam,Y.W., Hwang,G., Ryu,H.S., Seo,J., Lee,E.W., Ko,H.W. and Song,J.
    Opposing regulation of the K63-linked polyubiquitination of RIPK3 by SMURF1 and USP5 in necroptosis
    Nat Commun (2025) 16, 7360-7360. PubMed  Europe PubMed DOI  PMC  EPMC
  6. Jiang,S., Jiang,L., Xu,Y., Ma,Y., Deng,Y., Jiao,C., Yin,M., Qin,C., Li,J., Zhang,L. and Chen,S.
    USP5 deubiquitinates and stabilizes IMPDH2, to promote hepatocellular carcinoma progression
    Oncogene (2025) PubMed  Europe PubMed DOI
  7. Liang,L., Jia,W., Wang,J., Feng,Y., Zhu,D., Zhao,W., Xu,C., Ling,X., Lv,Q., Ai,X., Kong,L. and Ding,W.
    LRP11 facilitates lipid metabolism and malignancy in hepatocellular carcinoma by stabilizing RACK1 through USP5 regulation
    Mol Med (2025) 31, 35-35. PubMed  Europe PubMed DOI  PMC  EPMC  K
  8. Long,S., Ding,T., Zheng,Y., Shao,J., Liu,Y. and Wang,Q.
    USP5 motivates immunosuppressive microenvironment in multiple myeloma by activating STAT2-PFKFB4-mediated glycolysis
    Cancer Immunol Immunother (2025) 74, 180-180. PubMed  Europe PubMed DOI  PMC  EPMC
  9. Ma,K., Li,Q., Zhang,Y., Wang,J., Jia,W., Liu,J., Liu,B., Li,Q., Wang,Q. and Zeng,K.
    CYP1B1 promotes angiogenesis and sunitinib resistance in clear cell renal cell carcinoma via USP5-mediated HIF2alpha deubiquitination
    Neoplasia (2025) 66, 101186-101186. PubMed  Europe PubMed DOI
  10. Ma,L., Zhang,K., Zhang,Z., Wang,C., Ma,M., Liu,Y., Zhao,Y., Gong,Z., Liu,N., Wei,M., Liu,X., Zhou,J., Liu,S., Yang,C. and Yang,G.
    USP5 inhibition enables potential therapy for t(8;21) AML through ubiquitin-mediated AML1-ETO degradation in patient-derived xenografts
    Sci Transl Med (2025) 17, eadt9100-eadt9100. PubMed  Europe PubMed DOI  K
  11. Oak,S., Karajgikar,O., Gadewal,N., Sulkshane,P., Verma,T., Gupta,S. and Teni,T.
    The deubiquitinase inhibitor WP1130 drives nuclear aggregation and reactivation of mutant p53 for selective cancer cell targeting
    FEBS J (2025) PubMed  Europe PubMed DOI  I
  12. Qiao,Z., Li,D., Zhang,F., Zhu,J., Liu,S., Bai,X., Yao,H., Chen,Z., Yan,Y., Xu,X. and Ma,F.
    USP5 inhibits anti-RNA viral innate immunity by deconjugating K48-linked unanchored and K63-linked anchored ubiquitin on IRF3
    PLoS Pathog (2025) 21, e1012843-e1012843. PubMed  Europe PubMed DOI  PMC  EPMC
  13. Shao,N., Xi,L., Lv,Y., Idris,M., Zhang,L., Cao,Y., Xiang,J., Xu,X., Ong,B.X., Zhang,Q., Peng,X., Yue,X., Xu,F. and Liu,C.
    USP5 stabilizes YTHDF1 to control cancer immune surveillance through mTORC1-mediated phosphorylation
    Nat Commun (2025) 16, 1313-1313. PubMed  Europe PubMed DOI  PMC  EPMC
  14. Tang,J.Y., Peng,Y.X., Zhu,W., Qiu,J.Y., Huang,W., Yi,H., Lu,S.S., Feng,J., Yu,Z.Z., Wu,D., Wen,Q., Yuan,L., Peng,J. and Xiao,Z.Q.
    USP5 Binds and Stabilizes EphA2 to Increase Nasopharyngeal Carcinoma Radioresistance
    Int J Biol Sci (2025) 21, 893-909. PubMed  Europe PubMed DOI  PMC  EPMC
  15. Xiao,X., Shi,J., He,C., Bu,X., Sun,Y., Gao,M., Xiang,B., Xiong,W., Dai,P., Mao,Q., Xing,X., Yao,Y., Yu,H., Xu,G., Li,S., Ren,Y., Chen,B., Jiang,C., Meng,G., Lee,Y.R., Wei,W., Freeman,G.J., Xie,C. and Zhang,J.
    Author Correction: ERK and USP5 govern PD-1 homeostasis via deubiquitination to modulate tumor immunotherapy
    Nat Commun (2025) 16, 5357-5357. PubMed  Europe PubMed DOI  PMC  EPMC
  16. Xiong,N., Wang,Y. and Jiang,J.
    USP5 Promotes Head and Neck Squamous Cell Carcinoma Progression via mTOR Signaling Pathway
    Cancer Med (2025) 14, e70752-e70752. PubMed  Europe PubMed DOI  PMC  EPMC  K
  17. Yang,Z., Yu,Z., Teng,J., Yanzhang,R., Yu,Y., Zhang,H., Jin,G. and Wang,F.
    PDK1-mediated phosphorylation of USP5 modulates NF-kappaB signalling to enhance osteosarcoma growth
    Int J Biol Macromol (2025) 306, 141378-141378. PubMed  Europe PubMed DOI
  18. Yao,L., Lai,Y., Li,H., Chen,S., Yu,X., Zhou,N. and Lang,D.
    USP5 Deletion Inhibits KD Serum Induced-Human Coronary Artery Endothelial Cell Dysfunction by Regulating the NFATC1/TLR4-Mediated NF-kappaB Signaling Pathway in Kawasaki Disease
    Inflammation (2025) PubMed  Europe PubMed DOI
  19. Zhang,Y., Zhu,W., Tao,R., Li,W., Jiang,C. and Yan,X.
    Endogenous peptide CBDP1 inhibits clear cell renal cell carcinoma progression by targeting USP5/YTHDF2/TRPM5 axis
    J Transl Med (2025) 23, 116-116. PubMed  Europe PubMed DOI  PMC  EPMC
  20. [YEAR:1-10-2024]
    RETRACTION: MiR-125a Suppresses Malignancy of Multiple Myeloma by Reducing the Deubiquitinase USP5
    J Cell Biochem (1-10-2024) 125, e30628-e30628. PubMed  Europe PubMed DOI
    21. 2024
  21. Cai,H., Ke,Z.B., Chen,J.Y., Li,X.D., Zhu,J.M., Xue,Y.T., Ruan,Z.T., Wang,Z., Lin,F., Zheng,Q.S., Wei,Y., Xue,X.Y. and Xu,N.
    Ubiquitin-specific protease 5 promotes bladder cancer progression through stabilizing Twist1
    Oncogene (2024) 43, 703-713. PubMed  Europe PubMed DOI
  22. Capuano,A., D'Urso,G., Aliberti,M., Ruggiero,D., Terracciano,S., Festa,C., Tosco,A., Chini,M.G., Lauro,G., Bifulco,G. and Casapullo,A.
    Chemoproteomics Reveals USP5 (Ubiquitin Carboxyl-Terminal Hydrolase 5) as Promising Target of the Marine Polyketide Gracilioether A
    Mar Drugs (2024) 22 PubMed  Europe PubMed DOI  PMC  EPMC
  23. Gao,S.T., Xin,X., Wang,Z.Y., Hu,Y.Y. and Feng,Q.
    USP5: Comprehensive insights into structure, function, biological and disease-related implications, and emerging therapeutic opportunities
    Mol Cell Probes (2024) 73, 101944-101944. PubMed  Europe PubMed DOI  V
  24. Gu,J., Chen,C., He,P., Du,Y. and Zhu,B.
    Unraveling the Immune Regulatory Functions of USP5: Implications for Disease Therapy
    Biomolecules (2024) 14 PubMed  Europe PubMed DOI  PMC  EPMC  V
  25. Guo,H., Liu,R., Lv,H., Huo,Q., Yao,Y. and Lu,X.
    USP5 facilitates diabetic retinopathy development by stabilizing ROBO4 via deubiquitination
    Cell Signal (2024) 120, 111225-111225. PubMed  Europe PubMed DOI  K
  26. Jiang,X., You,H., Niu,Y., Ding,Y., Chen,Z., Wang,H., Xu,Y., Zhou,P., Wei,L., Deng,D., Xue,L., Peng,Y., Yang,Y., Fan,L. and Shao,N.
    E2F1-regulated USP5 contributes to the tumorigenic capacity of glioma stem cells through the maintenance of OCT4 stability
    Cancer Lett (2024) , 216875-216875. PubMed  Europe PubMed DOI
  27. Li,Y., Qiu,G., Zhou,M., Chen,Q. and Liao,X.
    USP5 Stabilizes IKBKG Through Deubiquitination to Suppress Ferroptosis and Promote Growth in Non-small Cell Lung Cancer
    Cell Biochem Biophys (2024) PubMed  Europe PubMed DOI
  28. Lu,R., Jin,Y. and Zheng,M.
    USP5-dependent HDAC1 promotes cisplatin resistance and the malignant progression of non-small cell lung cancer by regulating RILP acetylation levels
    Thorac Cancer (2024) PubMed  Europe PubMed DOI
  29. Ning,F., Du,L., Li,J., Wu,T., Zhou,J., Chen,Z., Hu,X., Zhang,Y., Luan,X., Xin,H., Yuan,C. and Zhang,X.
    The deubiquitinase USP5 promotes cholangiocarcinoma progression by stabilizing YBX1
    Life Sci (2024) 348, 122674-122674. PubMed  Europe PubMed DOI
  30. Olie,C.S., O'Brien,D.P., Jones,H.B.L., Liang,Z., Damianou,A., Sur-Erdem,I., Pinto-Fernandez,A., Raz,V. and Kessler,B.M.
    Deubiquitinases in muscle physiology and disorders
    Biochem Soc Trans (2024) 52, 1085-1098. PubMed  Europe PubMed DOI  V
  31. Peng,Z.M., Han,X.J., Wang,T., Li,J.J., Yang,C.X., Tou,F.F. and Zhang,Z.
    PFKP deubiquitination and stabilization by USP5 activate aerobic glycolysis to promote triple-negative breast cancer progression
    Breast Cancer Res (2024) 26, 10-10. PubMed  Europe PubMed DOI  PMC  EPMC
  32. Song,J., Liu,L., Wang,F. and Bao,D.
    Targeting Ubiquitin-specific Protease 5 Overcomes Chemoresistance via Negatively Regulating p53 in Gastric Cancer
    Curr Mol Med (2024) PubMed  Europe PubMed DOI  K
  33. Sun,H., Cui,Z., Li,C., Gao,Z., Xu,J., Bian,Y., Gu,T., Zhang,J., Li,T., Zhou,Q., Yang,D., He,Z., Li,B., Li,F., Xu,Z. and Xu,H.
    USP5 Promotes Ripretinib Resistance in Gastrointestinal Stromal Tumors by MDH2 Deubiquition
    Adv Sci (Weinh) (2024) , e2401171-e2401171. PubMed  Europe PubMed DOI
  34. Sun,W., Lu,H., Ma,L., Ding,C., Wang,H. and Chu,Y.
    Deubiquitinase USP5 regulates RIPK1 driven pyroptosis in response to myocardial ischemic reperfusion injury
    Cell Commun Signal (2024) 22, 466-466. PubMed  Europe PubMed DOI  PMC  EPMC
  35. Tian,Y., Chen,W.M. and Zhang,Y.
    [Clinical Significance of USP5 Expression Level in Acute Myeloid Leukemia and Its Regulatory Effects on AKT/mTOR/4EBP1 Signaling Pathway]
    Zhongguo Shi Yan Xue Ye Xue Za Zhi (2024) 32, 670-678. PubMed  Europe PubMed DOI  K
  36. Wan,Q.K., Li,T.T., Liu,B.B. and He,B.
    USP5 promotes tumor progression by stabilizing SLUG in bladder cancer
    Oncol Lett (2024) 28, 572-572. PubMed  Europe PubMed DOI  PMC  EPMC  K
  37. Wang,J., Fang,S., Jiang,Y. and Hua,Q.
    Unraveling the Mechanism of Action of Ubiquitin-Specific Protease 5 and Its Inhibitors in Tumors
    Clin Med Insights Oncol (2024) 18, 11795549241281932-11795549241281932. PubMed  Europe PubMed DOI  PMC  EPMC
  38. Wang,T., Tong,J., Zhang,X., Wang,Z., Xu,L., Pan,P. and Hou,T.
    Structure-based virtual screening of novel USP5 inhibitors targeting the zinc finger ubiquitin-binding domain
    Comput Biol Med (2024) 174, 108397-108397. PubMed  Europe PubMed DOI
  39. Wu,Q., Liu,R., Yang,Y., Peng,J., Huang,J., Li,Z., Huang,K. and Zhu,X.
    USP5 promotes tumorigenesis by activating Hedgehog/Gli1 signaling pathway in osteosarcoma
    Am J Cancer Res (2024) 14, 1204-1216. PubMed  Europe PubMed DOI  PMC  EPMC
  40. Zhang,H.H., Zhang,A.Q., Peng,P., Huang,L., Liu,C.Y., Nie,X.R., Hou,D.F., Zhang,X. and Li,S.Z.
    USP5 facilitates bladder cancer progression by stabilizing the c-Jun protein
    Cancer Cell Int (2024) 24, 32-32. PubMed  Europe PubMed DOI  PMC  EPMC
    41. 2023
  41. Ali,M.Y., Gadotti,V.M., Huang,S., Garcia-Caballero,A., Antunes,F.T.T., Jung,H.A., Choi,J.S. and Zamponi,G.W.
    Icariside II, a Prenyl-Flavonol, Alleviates Inflammatory and Neuropathic Pain by Inhibiting T-Type Calcium Channels and USP5-Cav3.2 Interactions
    ACS Chem Neurosci (2023) 14, 1859-1869. PubMed  Europe PubMed DOI
  42. Cao,L., Liu,H., Huang,C., Guo,C., Zhao,L., Gao,C., Xu,Y., Wang,G., Liang,N. and Li,S.
    USP5 knockdown alleviates lung cancer progression via activating PARP1-mediated mTOR signaling pathway
    Biol Direct (2023) 18, 16-16. PubMed  Europe PubMed DOI  PMC  EPMC
  43. Shi,S., Pan,X., Chen,M., Zhang,L., Zhang,S., Wang,X., Shi,S., Chen,Z., Lin,W. and Jiang,Y.
    USP5 promotes lipopolysaccharide-induced apoptosis and inflammatory response by stabilizing the TXNIP protein
    Hepatol Commun (2023) 7 PubMed  Europe PubMed DOI  PMC  EPMC  K
  44. Tung,C.H., Wu,J.E., Huang,M.F., Wang,W.L., Wu,Y.Y., Tsai,Y.T., Hsu,X.R., Lin,S.H., Chen,Y.L. and Hong,T.M.
    Ubiquitin-specific peptidase 5 facilitates cancer stem cell-like properties in lung cancer by deubiquitinating beta-catenin
    Cancer Cell Int (2023) 23, 207-207. PubMed  Europe PubMed DOI  PMC  EPMC
  45. Wang,Q., Chen,F., Yang,N., Xu,L., Yu,X., Wu,M. and Zhou,Y.
    DEPDC1B-mediated USP5 deubiquitination of beta-catenin promotes breast cancer metastasis by activating the wnt/beta-catenin pathway
    Am J Physiol Cell Physiol (2023) 325, C833-C833. PubMed  Europe PubMed DOI  PMC  EPMC
  46. Xia,P., Zhang,H., Lu,H., Xu,K., Jiang,X., Jiang,Y., Gongye,X., Chen,Z., Liu,J., Chen,X., Ma,W., Zhang,Z. and Yuan,Y.
    METTL5 stabilizes c-Myc by facilitating USP5 translation to reprogram glucose metabolism and promote hepatocellular carcinoma progression
    Cancer Commun (Lond) (2023) 43, 338-364. PubMed  Europe PubMed DOI  PMC  EPMC
  47. Xiao,X., Shi,J., He,C., Bu,X., Sun,Y., Gao,M., Xiang,B., Xiong,W., Dai,P., Mao,Q., Xing,X., Yao,Y., Yu,H., Xu,G., Li,S., Ren,Y., Chen,B., Jiang,C., Meng,G., Lee,Y.R., Wei,W., Freeman,G.J., Xie,C. and Zhang,J.
    ERK and USP5 govern PD-1 homeostasis via deubiquitination to modulate tumor immunotherapy
    Nat Commun (2023) 14, 2859-2859. PubMed  Europe PubMed DOI  PMC  EPMC
  48. Yan,B., Guo,J., Deng,S., Chen,D. and Huang,M.
    A pan-cancer analysis of the role of USP5 in human cancers
    Sci Rep (2023) 13, 8972-8972. PubMed  Europe PubMed DOI  PMC  EPMC
    49. 2022
  49. Bailly,C.
    Anti-inflammatory and anticancer p-terphenyl derivatives from fungi of the genus Thelephora
    Bioorg Med Chem (2022) 70, 116935-116935. PubMed  Europe PubMed DOI  V  I
  50. Hill,J. and Nyathi,Y.
    USP5 enhances SGTA mediated protein quality control
    PLoS ONE (2022) 17, e0257786-e0257786. PubMed  Europe PubMed DOI  PMC  EPMC  K
  51. Huang,W., Liu,X., Zhang,Y., Deng,M., Li,G., Chen,G., Yu,L., Jin,L., Liu,T., Wang,Y. and Chen,Y.
    USP5 promotes breast cancer cell proliferation and metastasis by stabilizing HIF2alpha
    J Cell Physiol (2022) 237, 2211-2219. PubMed  Europe PubMed DOI
  52. Pahi,Z.G., Kovacs,L., Szucs,D., Borsos,B.N., Deak,P. and Pankotai,T.
    Usp5, Usp34, and Otu1 deubiquitylases mediate DNA repair in Drosophila melanogaster
    Sci Rep (2022) 12, 5870-5870. PubMed  Europe PubMed DOI  PMC  EPMC  K
    53. 2021
  53. Cai,B., Zhao,J., Zhang,Y., Liu,Y., Ma,C., Yi,F., Zheng,Y., Zhang,L., Chen,T., Liu,H., Liu,B. and Gao,C.
    USP5 attenuates NLRP3 inflammasome activation by promoting autophagic degradation of NLRP3
    Autophagy (2021) , 1-15. PubMed  Europe PubMed DOI
  54. Cheung,B.B., Kleynhans,A., Mittra,R., Kim,P.Y., Holien,J.K., Nagy,Z., Ciampa,O.C., Seneviratne,J.A., Mayoh,C., Raipuria,M., Gadde,S., Massudi,H., Wong,I.P.L., Tan,O., Gong,A., Suryano,A., Diakiw,S.M., Liu,B., Arndt,G.M., Liu,T., Kumar,N., Sangfelt,O., Zhu,S., Norris,M.D., Haber,M., Carter,D.R., Parker,M.W. and Marshall,G.M.
    A novel combination therapy targeting ubiquitin-specific protease 5 in MYCN-driven neuroblastoma
    Oncogene (2021) PubMed  Europe PubMed DOI
  55. Li,G., Yang,T., Chen,Y., Bao,J., Wu,D., Hu,X., Feng,C., Xu,L., Li,M., Li,G., Jin,M., Xu,Y., Zhang,R., Qian,G. and Pan,J.
    USP5 Sustains the Proliferation of Glioblastoma Through Stabilization of CyclinD1
    Front Pharmacol (2021) 12, 720307-720307. PubMed  Europe PubMed DOI  PMC  EPMC  K
  56. Li,L., Wang,S., Wang,M., Qi,G. and Zhao,H.
    Ubiquitin-Specific Peptidase 5 is Involved in the Proliferation of Trophoblast Cells by Regulating Wnt/beta-Catenin Signaling
    Mol Biotechnol (2021) PubMed  Europe PubMed DOI
  57. Li,Y. and Zhou,J.
    USP5 Promotes Uterine Corpus Endometrial Carcinoma Cell Growth and Migration via mTOR/4EBP1 Activation
    Cancer Manag Res (2021) 13, 3913-3924. PubMed  Europe PubMed DOI  PMC  EPMC
  58. Mann,M.K., Zepeda-Velazquez,C.A., Gonzalez-Alvarez,H., Dong,A., Kiyota,T., Aman,A.M., Loppnau,P., Li,Y., Wilson,B., Arrowsmith,C.H., Al-Awar,R., Harding,R.J. and Schapira,M.
    Structure-Activity Relationship of USP5 Inhibitors
    J Med Chem (2021) 64, 15017-15036. PubMed  Europe PubMed DOI
  59. Pan,J., Qiao,Y., Chen,C., Zang,H., Zhang,X., Qi,F., Chang,C., Yang,F., Sun,M., Lin,S., Tang,Q., Li,L., Wang,M., Wu,M., Liu,Y., Lai,C., Chen,J. and Chen,G.
    USP5 facilitates non-small cell lung cancer progression through stabilization of PD-L1
    Cell Death Dis (2021) 12, 1051-1051. PubMed  Europe PubMed DOI  PMC  EPMC  K
  60. Sutherland,C.J., Henrici,R.C. and Artavanis-Tsakonas,K.
    Artemisinin susceptibility in the malaria parasite Plasmodium falciparum: propellers, adaptor proteins and the need for cellular healing
    FEMS Microbiol Rev (2021) 45, fuaa056-fuaa056. PubMed  Europe PubMed DOI  I
  61. Zhang,Z., Cui,Z., Xie,Z., Li,C., Xu,C., Guo,X., Yu,J., Chen,T., Facchinetti,F., Bohnenberger,H., Leong,T.L., Xie,Y., Mao,X. and Zhao,J.
    Deubiquitinase USP5 promotes non-small cell lung cancer cell proliferation by stabilizing cyclin D1
    Transl Lung Cancer Res (2021) 10, 3995-4011. PubMed  Europe PubMed DOI  PMC  EPMC  K
    62. 2020
  62. Lian,J., Liu,C., Guan,X., Wang,B., Yao,Y., Su,D., Ma,Y., Fang,L. and Zhang,Y.
    Ubiquitin specific peptidase 5 enhances STAT3 signaling and promotes migration and invasion in Pancreatic Cancer
    J Cancer (2020) 11, 6802-6811. PubMed  Europe PubMed DOI  PMC  EPMC
  63. Qian,G., Zhu,L., Huang,C., Liu,Y., Ren,Y., Ding,Y., Qian,W., Xu,Q., Zheng,H. and Lv,H.
    Ubiquitin specific protease 5 negatively regulates the IFNs-mediated antiviral activity via targeting SMURF1
    Int Immunopharmacol (2020) 87, 106763-106763. PubMed  Europe PubMed DOI
  64. Sun,H.L., Zhu,A.C., Gao,Y., Terajima,H., Fei,Q., Liu,S., Zhang,L., Zhang,Z., Harada,B.T., He,Y.Y., Bissonnette,M.B., Hung,M.C. and He,C.
    Stabilization of ERK-Phosphorylated METTL3 by USP5 Increases m(6)A Methylation
    Mol Cell (2020) 80, 633-647. PubMed  Europe PubMed DOI  PMC  EPMC
  65. Vashistha,V., Bhardwaj,S., Yadav,B.K. and Yadav,A.K.
    Depleting deubiquitinating enzymes promotes apoptosis in glioma cell line via RNA binding proteins SF2/ASF1
    Biochem Biophys Rep (2020) 24, 100846-100846. PubMed  Europe PubMed DOI  PMC  EPMC  K  I
  66. Xia,L., Shi,Y., Su,J., Friedemann,T., Tao,Z., Lu,Y., Ling,Y., Lv,Y., Zhao,R., Geng,Z., Cui,X., Lu,H. and Schroder,S.
    Shufeng Jiedu, a promising herbal therapy for moderate COVID-19:Antiviral and anti-inflammatory properties, pathways of bioactive compounds, and a clinical real-world pragmatic study
    Phytomedicine (2020) , 153390-153390. PubMed  Europe PubMed DOI  PMC  EPMC  I
  67. Xiao,M., Liu,J., Xiang,L., Zhao,K., He,D., Zeng,Q., Zhang,Q., Xie,D., Deng,M., Zhu,Y., Zhang,Y., Liu,Y., Bo,H., Liu,X., Chen,X., Gong,L., Bao,Y., Hu,Y., Cheng,Y., Deng,L., Zhu,R., Xing,X., Zhou,M., Xiong,W., Zhou,Y., Zhou,J., Li,X. and Cao,K.
    MAFG-AS1 promotes tumor progression via regulation of the HuR/PTBP1 axis in bladder urothelial carcinoma
    Clin Transl Med (2020) 10, e241-e241. PubMed  Europe PubMed DOI  PMC  EPMC
  68. Xue,S., Wu,W., Wang,Z., Lu,G., Sun,J., Jin,X., Xie,L., Wang,X., Tan,C., Wang,Z., Wang,W. and Ding,X.
    Corrigendum: USP5 Promotes Metastasis in Non-Small Cell Lung Cancer by Inducing Epithelial-Mesenchymal Transition via Wnt/beta-Catenin Pathway
    Front Pharmacol (2020) 11, 948-948. PubMed  Europe PubMed DOI  PMC  EPMC
    69. 2019
  69. Du,Y., Lin,J., Zhang,R., Yang,W., Quan,H., Zang,L., Han,Y., Li,B., Sun,H. and Wu,J.
    Ubiquitin specific peptidase 5 promotes ovarian cancer cell proliferation through deubiquitinating HDAC2
    Aging (Albany NY) (2019) 11, 9778-9793. PubMed  Europe PubMed DOI
  70. Mann,M.K., Franzoni,I., de Freitas,R.F., Tempel,W., Houliston,S., Smith,L., Vedadi,M., Arrowsmith,C.H., Harding,R.J. and Schapira,M.
    Discovery of small molecule antagonists of the USP5 zinc finger ubiquitin-binding domain
    J Med Chem (2019) 62, 10144-10155. PubMed  Europe PubMed DOI  I
  71. Ning,F., Xin,H., Liu,J., Lv,C., Xin,X., Wang,M., Wang,Y., Zhang,W. and Zhang,X.
    Structure and function of USP5: insight into physiological and pathophysiological roles
    Pharmacol Res (2019) , 104557-104557. PubMed  Europe PubMed DOI
  72. Xu,X., Huang,A., Cui,X., Han,K., Hou,X., Wang,Q., Cui,L. and Yang,Y.
    Ubiquitin specific peptidase 5 regulates colorectal cancer cell growth by stabilizing Tu translation elongation factor
    Theranostics (2019) 9, 4208-4220. PubMed  Europe PubMed DOI  PMC  EPMC
    73. 2018
  73. Kim,S.Y., Kwon,S.K., Lee,S.Y. and Baek,K.H.
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