Literature for subfamily C14A
(Topics flags: S Structure, A Assay, P Specificity, I Inhibitor, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)
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Tang,P., Chen,Y., Yue,T., Liang,Z., Yang,J., Wang,Q., He,Y., Qin,C., Wen,Z., Shi,Q., Zhou,L. and Wang,J.
Identification, evolutionary and characteristic analysis of apoptosis - related caspase gene family in Tachysurus fulvidraco and their expression profiles under bacterial, parasitic, and viral infections
Fish Shellfish Immunol (2026) 168, 111006-111006. PubMed Europe PubMed DOI -
White,M.A., Crowley,L., Massenzio,F., Li,X., Niblock,M., Milani,S., Coleman,M.P., Barmada,S.J. and Sreedharan,J.
Inhibiting Glycogen Synthase Kinase 3 Suppresses TDP-43-Mediated Neurotoxicity in a Caspase-Dependent Manner
Mol Neurobiol (2026) 63, 370-370. PubMed Europe PubMed DOI PMC EPMC -
Worfolk,S.M., Phippen,N.J., Verburg,S.G., Kobal,K.A., Langelaan,N.C., Gongora,D.G., Geddes-McAlister,J., Wootton,S.K., Miller,M.S. and Workenhe,S.T.
Activation of RIPK3 drives PANoptosis in human cells and inflammatory apoptosis in canine cells dependent on RIPK1, FADD and caspases
Apoptosis (2026) 31, 40-40. PubMed Europe PubMed DOI -
Ahmed,A. and Tait,S.W.G.
Molecular Cell Biology of Apoptosis in Health and Disease
Adv Exp Med Biol (2025) 1481, 1-28. PubMed Europe PubMed DOI -
Beltran-Visiedo,M., Soler-Agesta,R., Sarosiek,K.A., Green,D.R. and Galluzzi,L.
Regulation of inflammatory processes by caspases
Nat Rev Mol Cell Biol (2025) PubMed Europe PubMed DOI -
Cao,Z., Qin,L., Liu,K., Yao,C., Li,E., Hao,X., Wang,M., Jiang,B., Zou,Y., Hu,H., Liu,Q., Shao,C., Gong,Y. and Sun,G.
Sublethal executioner caspase activation in hepatocytes promotes liver regeneration through the JAK/STAT3 pathway
PLoS Biol (2025) 23, e3003357-e3003357. PubMed Europe PubMed DOI PMC EPMC -
Figueras-Novoa,C., Akutsu,M., Murata,D., Weston,A., Jiang,M., Montaner,B., Dubois,C., Shenoy,A. and Beale,R.
Caspase cleavage of influenza A virus M2 disrupts M2-LC3 interaction and regulates virion production
EMBO Rep (2025) PubMed Europe PubMed DOI -
Grant,S. and Boucher,D.
10 things you wish you knew about inflammatory caspases: a holistic review of their biochemistry, activation, and signalling
J Biol Chem (2025) , 110557-110557. PubMed Europe PubMed DOI -
Abdelghany,L., Sillapachaiyaporn,C. and Zhivotovsky,B.
The concealed side of caspases: beyond a killer of cells
Cell Mol Life Sci (2024) 81, 474-474. PubMed Europe PubMed DOI PMC EPMC -
Ai,Y., Meng,Y., Yan,B., Zhou,Q. and Wang,X.
The biochemical pathways of apoptotic, necroptotic, pyroptotic, and ferroptotic cell death
Mol Cell (2024) 84, 170-179. PubMed Europe PubMed DOI V -
Allani,M., Akhilesh and Tiwari,V.
Caspase-driven cancer therapies: Navigating the bridge between lab discoveries and clinical applications
Cell Biochem Funct (2024) 42, e3944-e3944. PubMed Europe PubMed DOI V -
Baena-Lopez,L.A., Wang,L. and Wendler,F.
Cellular stress management by caspases
Curr Opin Cell Biol (2024) 86, 102314-102314. PubMed Europe PubMed DOI -
Exconde,P.M., Bourne,C.M., Kulkarni,M., Discher,B.M. and Taabazuing,C.Y.
Inflammatory caspase substrate specificities
MBio (2024) , e0297523-e0297523. PubMed Europe PubMed DOI -
Hao,K., Yuan,L., Yu,C., Xu,H. and Sun,L.
Paralichthys olivaceus GSDME-mediated pyroptosis is regulated by multiple caspases in different manners
Fish Shellfish Immunol (2024) 155, 110002-110002. PubMed Europe PubMed DOI -
Kasana,S., Kumar,S., Patel,P., Kurmi,B.D., Jain,S., Sahu,S. and Vaidya,A.
Caspase inhibitors: a review on recently patented compounds (2016-2023)
Expert Opin Ther Pat (2024) , 1-26. PubMed Europe PubMed DOI -
Liu,J., Fischer,A., Cserjan-Puschmann,M., Lingg,N. and Oostenbrink,C.
Caspase-Based Fusion Protein Technology: Substrate Cleavability Described by Computational Modeling and Simulation
J Chem Inf Model (2024) 64, 5691-5700. PubMed Europe PubMed DOI -
Xiao,C. and Li,X.
Pyroptosis and sepsis-associated acute kidney injury
Zhong Nan Da Xue Xue Bao Yi Xue Ban (2024) 49, 1333-1340. PubMed Europe PubMed DOI PMC EPMC -
Alshiraihi,I. and Kato,T.A.
Apoptosis Detection Assays
Methods Mol Biol (2023) 2519, 53-63. PubMed Europe PubMed DOI -
Bastami,Z., Sheikhpour,R., Razzaghi,P., Ramazani,A. and Gharaghani,S.
Proteochemometrics modeling for prediction of the interactions between caspase isoforms and their inhibitors
Mol Divers (2023) 27, 249-261. PubMed Europe PubMed DOI -
Hua,T., Robitaille,M., Roberts-Thomson,S.J. and Monteith,G.R.
The intersection between cysteine proteases, Ca(2+) signalling and cancer cell apoptosis
Biochim Biophys Acta Mol Cell Res (2023) 1870, 119532-119532. PubMed Europe PubMed DOI V -
Joglekar,I. and Clark,A.C.
Sequential Unfolding Mechanisms of Monomeric Caspases
Biochemistry (2023) 62, 1878-1889. PubMed Europe PubMed DOI PMC EPMC -
Sahoo,G., Samal,D., Khandayataray,P. and Murthy,M.K.
A Review on Caspases: Key Regulators of Biological Activities and Apoptosis
Mol Neurobiol (2023) 60, 5805-5837. PubMed Europe PubMed DOI V -
Bibo-Verdugo,B. and Salvesen,G.S.
Caspase mechanisms in the regulation of inflammation
Mol Aspects Med (2022) 88, 101085-101085. PubMed Europe PubMed DOI V -
Zhang,A., Zhang,Z., Liu,Y., Lenahan,C., Xu,H., Jiang,J., Yuan,L., Wang,L., Xu,Y., Chen,S., Fang,Y. and Zhang,J.
The role of caspase family in acute brain injury: the potential therapeutic targets in the future
Curr Neuropharmacol (2022) 20, 1194-1211. PubMed Europe PubMed DOI -
Sharma,A., Gogoi,P., Chandravanshi,M. and Kanaujia,S.P.
Water-mediated structural rearrangement establishes active conformation of caspases for apoptosis and inflammation
J Biomol Struct Dyn (2021) , 1-14. PubMed Europe PubMed DOI -
Shrestha,S. and Clark,A.C.
Evolution of the folding landscape of effector caspases
J Biol Chem (2021) 297, 101249-101249. PubMed Europe PubMed DOI -
Weeks,A.M.
Kinases leave their mark on caspase substrates
Biochem J (2021) 478, 3179-3184. PubMed Europe PubMed DOI -
Unsain,N. and Barker,P.A.
New views on the misconstrued: executioner caspases and their diverse non-apoptotic roles
Neuron (2015) 88, 461-474. PubMed Europe PubMed DOI -
Kumar,S.
Caspase function in programmed cell death
Cell Death Differ (2007) 14, 32-43. PubMed Europe PubMed DOI V -
Lamkanfi,M., Festjens,N., Declercq,W., Vanden Berghe,T. and Vandenabeele,P.
Caspases in cell survival, proliferation and differentiation
Cell Death Differ (2007) 14, 44-55. PubMed Europe PubMed DOI V -
Sexton,K.B., Kato,D., Berger,A.B., Fonovic,M., Verhelst,S.H. and Bogyo,M.
Specificity of aza-peptide electrophile activity-based probes of caspases
Cell Death Differ (2007) 14, 727-732. PubMed Europe PubMed DOI I -
Wee,L.J., Tan,T.W. and Ranganathan,S.
CASVM: web server for SVM-based prediction of caspase substrates cleavage sites
Bioinformatics (2007) 23, 3241-3243. PubMed Europe PubMed DOI P -
[YEAR:28-12-2006]Henzing,A.J., Dodson,H., Reid,J.M., Kaufmann,S.H., Baxter,R.L. and Earnshaw,W.C.
Synthesis of novel caspase inhibitors for characterization of the active caspase proteome in vitro and in vivo
J Med Chem (28-12-2006) 49, 7636-7645. PubMed Europe PubMed DOI PMC EPMC I -
[YEAR:15-9-2006]Vallender,E.J. and Lahn,B.T.
A primate-specific acceleration in the evolution of the caspase-dependent apoptosis pathway
Hum Mol Genet (15-9-2006) 15, 3034-3040. PubMed Europe PubMed DOI -
Faubel,S. and Edelstein,C.L.
Caspases as drug targets in ischemic organ injury
Curr Drug Targets Immune Endocr Metabol Disord (2005) 5, 269-287. PubMed Europe PubMed DOI -
[YEAR:1-6-2005]Garay-Malpartida,H.M., Occhiucci,J.M., Alves,J. and Belizario,J.E.
CaSPredictor: a new computer-based tool for caspase substrate prediction
Bioinformatics (1-6-2005) 21 Suppl 1, i169-i176. PubMed Europe PubMed DOI -
Ho,P.K. and Hawkins,C.J.
Mammalian initiator apoptotic caspases
FEBS J (2005) 272, 5436-5453. PubMed Europe PubMed DOI V -
Lavrik,I.N., Golks,A. and Krammer,P.H.
Caspases: pharmacological manipulation of cell death
J Clin Invest (2005) 115, 2665-2672. PubMed Europe PubMed DOI PMC EPMC V -
[YEAR:1-3-2005]Wang,Y., Guan,L., Jia,S., Tseng,B., Drewe,J. and Cai,S.X.
Dipeptidyl aspartyl fluoromethylketones as potent caspase inhibitors: peptidomimetic replacement of the P2 alpha-amino acid by a alpha-hydroxy acid
Bioorg Med Chem Lett (1-3-2005) 15, 1379-1383. PubMed Europe PubMed DOI I -
[YEAR:7-4-2005]Weill,M., Philips,A., Chourrout,D. and Fort,P.
The caspase family in urochordates: distinct evolutionary fates in ascidians and larvaceans
Biol Cell (7-4-2005) 97, 857-866. PubMed Europe PubMed DOI -
McLaughlin,B.
The kinder side of killer proteases: caspase activation contributes to neuroprotection and CNS remodeling
Apoptosis (2004) 9, 111-121. PubMed Europe PubMed DOI -
Onteniente,B.
Natural and synthetic inhibitors of caspases: targets for novel drugs
Curr Drug Targets CNS Neurol Disord (2004) 3, 333-340. PubMed Europe PubMed DOI I -
Philchenkov,A.
Caspases: potential targets for regulating cell death
J Cell Mol Med (2004) 8, 432-444. PubMed Europe PubMed -
Riedl,S.J. and Shi,Y.
Molecular mechanisms of caspase regulation during apoptosis
Nat Rev Mol Cell Biol (2004) 5, 897-907. PubMed Europe PubMed DOI V -
Boatright,K.M. and Salvesen,G.S.
Caspase activation
Biochem Soc Symp (2003) , 233-242. PubMed Europe PubMed -
Boatright,K.M., Renatus,M., Scott,F.L., Sperandio,S., Shin,H., Pedersen,I.M., Ricci,J.E., Edris,W.A., Sutherlin,D.P., Green,D.R. and Salvesen,G.S.
A unified model for apical caspase activation
Mol Cell (2003) 11, 529-541. PubMed Europe PubMed DOI -
Boatright,K.M. and Salvesen,G.S.
Mechanisms of caspase activation
Curr Opin Cell Biol (2003) 15, 725-731. PubMed Europe PubMed DOI -
[YEAR:9-5-2003]Chang,D.W., Ditsworth,D., Liu,H., Srinivasula,S.M., Alnemri,E.S. and Yang,X.
Oligomerization is a general mechanism for the activation of apoptosis initiator and inflammatory procaspases
J Biol Chem (9-5-2003) 278, 16466-16469. PubMed Europe PubMed DOI -
[YEAR:15-4-2003]Chereau,D., Kodandapani,L., Tomaselli,K.J., Spada,A.P. and Wu,J.C.
Structural and functional analysis of caspase active sites
Biochemistry (15-4-2003) 42, 4151-4160. PubMed Europe PubMed DOI -
Fischer,U., Janicke,R.U. and Schulze-Osthoff,K.
Many cuts to ruin: a comprehensive update of caspase substrates
Cell Death Differ (2003) 10, 76-100. PubMed Europe PubMed DOI P -
[YEAR:1-8-2003]Sulpizi,M., Laio,A., VandeVondele,J., Cattaneo,A., Rothlisberger,U. and Carloni,P.
Reaction mechanism of caspases: insights from QM/MM Car-Parrinello simulations
Proteins (1-8-2003) 52, 212-224. PubMed Europe PubMed DOI -
[YEAR:17-2-2003]Wiens,M., Krasko,A., Perovic,S. and Muller,W.E.
Caspase-mediated apoptosis in sponges: cloning and function of the phylogenetic oldest apoptotic proteases from Metazoa
Biochim Biophys Acta (17-2-2003) 1593, 179-189. PubMed Europe PubMed DOI I -
Bayascas,J.R., Yuste,V.J., Benito,E., Garcia-Fernandez,J. and Comella,J.X.
Isolation of AmphiCASP-3/7, an ancestral caspase from amphioxus (Branchiostoma floridae). Evolutionary considerations for vertebrate caspases
Cell Death Differ (2002) 9, 1078-1089. PubMed Europe PubMed DOI -
Denault,J.B. and Salvesen,G.S.
Caspases: keys in the ignition of cell death
Chem Rev (2002) 102, 4489-4500. PubMed Europe PubMed DOI -
[YEAR:10-12-2002]Donepudi,M. and Grutter,M.G.
Structure and zymogen activation of caspases
Biophys Chem (10-12-2002) 101-102, 145-153. PubMed Europe PubMed DOI -
[YEAR:1-7-2002]Kohler,C., Orrenius,S. and Zhivotovsky,B.
Evaluation of caspase activity in apoptotic cells
J Immunol Methods (1-7-2002) 265, 97-110. PubMed Europe PubMed DOI -
[YEAR:1-7-2002]Richardson,H. and Kumar,S.
Death to flies: Drosophila as a model system to study programmed cell death
J Immunol Methods (1-7-2002) 265, 21-38. PubMed Europe PubMed DOI -
Deckwerth,T.L., Adams,L.M., Wiessner,C., Allegrini,P.R., Rudin,M., Sauter,A., Hengerer,B., Sayers,R.O., Rovelli,G., Aja,T., May,R., Nalley,K., Linton,S., Karanewsky,D.S., Wu,J.C., Roggo,S., Schmitz,A., Contreras,P.C. and Tomaselli,K.J.
Long-term protection of brain tissue from cerebral ischemia by peripherally administered peptidomimetic caspase inhibitors
Drug Dev Res (2001) 52, 579-586. I -
Ranger,A.M., Malynn,B.A. and Korsmeyer,S.J.
Mouse models of cell death
Nat Genet (2001) 28, 113-118. PubMed Europe PubMed DOI -
Wang,Y. and Gu,X.
Functional divergence in the caspase gene family and altered functional constraints: statistical analysis and prediction
Genetics (2001) 158, 1311-1320. PubMed Europe PubMed PMC EPMC -
[YEAR:5-6-2000]Komoriya,A., Packard,B.Z., Brown,M.J., Wu,M.L. and Henkart,P.A.
Assessment of caspase activities in intact apoptotic thymocytes using cell-permeable fluorogenic caspase substrates
J Exp Med (5-6-2000) 191, 1819-1828. PubMed Europe PubMed DOI PMC EPMC -
[YEAR:22-12-2000]Lin,X.Y., Choi,M.S. and Porter,A.G.
Expression analysis of the human caspase-1 subfamily reveals specific regulation of the CASP5 gene by lipopolysaccharide and interferon-gamma
J Biol Chem (22-12-2000) 275, 39920-39926. PubMed Europe PubMed DOI -
Roy,S. and Nicholson,D.W.
Criteria for identifying authentic caspase substrates during apoptosis
Methods Enzymol (2000) 322, 110-125. PubMed Europe PubMed V -
Stennicke,H.R. and Salvesen,G.S.
Caspase assays
Methods Enzymol (2000) 322, 91-100. PubMed Europe PubMed A V -
[YEAR:7-3-2000]Stennicke,H.R. and Salvesen,G.S.
Caspases - controlling intracellular signals by protease zymogen activation
Biochim Biophys Acta (7-3-2000) 1477, 299-306. PubMed Europe PubMed DOI -
[YEAR:7-9-2000]Talanian,R.V., Brady,K.D. and Cryns,V.L.
Caspases as targets for anti-inflammatory and anti-apoptotic drug discovery
J Med Chem (7-9-2000) 43, 3351-3371. PubMed Europe PubMed DOI -
Thornberry,N.A., Chapman,K.T. and Nicholson,D.W.
Determination of caspase specificities using a peptide combinatorial library
Methods Enzymol (2000) 322, 100-110. PubMed Europe PubMed V -
[YEAR:9-9-1999]Cikala,M., Wilm,B., Hobmayer,E., Bottger,A. and David,C.N.
Identification of caspases and apoptosis in the simple metazoan Hydra
Curr Biol (9-9-1999) 9, 959-962. PubMed Europe PubMed DOI -
Denner,L.
Caspases in apoptotic death
Expert Opin Investig Drugs (1999) 8, 37-50. PubMed Europe PubMed DOI V -
Deveraux,Q.L., Stennicke,H.R., Salvesen,G.S. and Reed,J.C.
Endogenous inhibitors of caspases
J Clin Immunol (1999) 19, 388-398. PubMed Europe PubMed -
Earnshaw,W.C., Martins,L.M. and Kaufmann,S.H.
Mammalian caspases: structure, activation, substrates, and functions during apoptosis
Annu Rev Biochem (1999) 68, 383-424. PubMed Europe PubMed DOI -
Nicholson,D.W.
Caspase structure, proteolytic substrates, and function during apoptotic cell death
Cell Death Differ (1999) 6, 1028-1042. PubMed Europe PubMed DOI -
Stennicke,H.R. and Salvesen,G.S.
Catalytic properties of the caspases
Cell Death Differ (1999) 6, 1054-1059. PubMed Europe PubMed DOI -
[YEAR:3-4-1998]Barinaga,M.
Death by dozens of cuts
Science (3-4-1998) 280, 32-34. PubMed Europe PubMed DOI -
[YEAR:1-6-1998]Cryns,V. and Yuan,J.
Proteases to die for
Genes Dev (1-6-1998) 12, 1551-1570. PubMed Europe PubMed V I -
[YEAR:15-4-1998]Deveraux,Q.L., Roy,N., Stennicke,H.R., Van Arsdale,T., Zhou,Q., Srinivasula,S.M., Alnemri,E.S., Salvesen,G.S. and Reed,J.C.
IAPs block apoptotic events induced by caspase-8 and cytochrome c by direct inhibition of distinct caspases
EMBO J (15-4-1998) 17, 2215-2223. PubMed Europe PubMed DOI PMC EPMC -
[YEAR:4-12-1998]Garcia-Calvo,M., Peterson,E.P., Leiting,B., Ruel,R., Nicholson,D.W. and Thornberry,N.A.
Inhibition of human caspases by peptide-based and macromolecular inhibitors
J Biol Chem (4-12-1998) 273, 32608-32613. PubMed Europe PubMed DOI I -
[YEAR:28-8-1998]Thornberry,N.A. and Lazebnik,Y.
Caspases: enemies within
Science (28-8-1998) 281, 1312-1316. PubMed Europe PubMed -
Alnemri,E.S.
Mammalian cell death proteases: a family of highly conserved aspartate specific cysteine proteases
J Cell Biochem (1997) 64, 33-42. PubMed Europe PubMed DOI V -
Cohen,G.M.
Caspases: the executioners of apoptosis
Biochem J (1997) 326, 1-16. PubMed Europe PubMed PMC EPMC -
Margolin,N., Raybuck,S.A., Wilson,K.P., Chen,W., Fox,T., Gu,Y. and Livingston,D.J.
Substrate and inhibitor specificity of interleukin-1beta-converting enzyme and related caspases
J Biol Chem (1997) 272, 7223-7228. PubMed Europe PubMed DOI S I -
Miller,D.K., Myerson,J. and Becker,J.W.
The interleukin-1beta converting enzyme family of cysteine proteases
J Cell Biochem (1997) 64, 2-10. PubMed Europe PubMed DOI -
Nicholson,D.W. and Thornberry,N.A.
Caspases: killer proteases
Trends Biochem Sci (1997) 22, 299-306. PubMed Europe PubMed DOI -
Thornberry,N.A.
The caspase family of cysteine proteases
Br Med Bull (1997) 53, 478-490. PubMed Europe PubMed -
Van de Craen,M., van den Brande,I., Declercq,W., Irmler,M., Beyaert,R., Tschopp,J., Fiers,W. and Vandenabeele,P.
Cleavage of caspase family members by granzyme B: a comparative study in vitro
Eur J Immunol (1997) 27, 1296-1299. PubMed Europe PubMed DOI -
Villa,P., Kaufmann,S.H. and Earnshaw,W.C.
Caspases and caspase inhibitors
Trends Biochem Sci (1997) 22, 388-393. PubMed Europe PubMed DOI -
Alnemri,E.S., Livingston,D.J., Nicholson,D.W., Salvesen,G., Thornberry,N.A., Wong,W.W. and Yuan,J.
Human ICE/CED-3 protease nomenclature
Cell (1996) 87, 171-171. PubMed Europe PubMed -
Takahashi,A. and Earnshaw,W.C.
ICE-related proteases in apoptosis
Curr Opin Genet Dev (1996) 6, 50-55. PubMed Europe PubMed DOI -
Bump,N.J., Hackett,M., Hugunin,M., Seshagiri,S., Brady,K., Chen,P., Ferenz,C., Franklin,S., Ghayur,T., Li,P., Licari,P., Mankovich,J., Shi,L.F., Greenberg,A.H., Miller,L.K. and Wong,W.W.
Inhibition of ICE family proteases by baculovirus antiapoptotic protein p35
Science (1995) 269, 1885-1888. PubMed Europe PubMed -
Kumar,S.
ICE-like proteases in apoptosis
Trends Biochem Sci (1995) 20, 198-202. PubMed Europe PubMed DOI V -
[YEAR:20-11-1995]Kumar,S. and Harvey,N.L.
Role of multiple cellular proteases in the execution of programmed cell death
FEBS Lett (20-11-1995) 375, 169-173. PubMed Europe PubMed DOI -
Milligan,C.E., Prevette,D., Yaginuma,H., Homma,S., Cardwell,C., Fritz,L.C., Tomaselli,K.J., Oppenheim,R.W. and Schwartz,L.M.
Peptide inhibitors of the ICE protease family arrest programmed cell death of motoneurons in vivo and in vitro
Neuron (1995) 15, 385-393. PubMed Europe PubMed -
[YEAR:10-3-1995]Thompson,C.B.
Apoptosis in the pathogenesis and treatment of disease
Science (10-3-1995) 267, 1456-1462. PubMed Europe PubMed
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