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Literature for peptidase homologue C14.971: FLIP protein

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature

(Topics flags: R Splicing, K Knockout, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Bader,M., Scherer,L., Bhandari,R., Motyer,A.J., Cooney,J.P., Mackiewicz,L., Dayton,M., Sheerin,D., Romero,V.L., Schaefer,J., Pang,J., Chen,S., Schoffer,K., Wang,L., Jin,X., Batey,D., Yip,R.K.H., Zaman,I., Rajasekhar,P., Gartner,M.J., Wilcox,S., Whitehead,L., Georgy,S.R., Maluenda,A., Davidson,K.C., Allison,C.C., Bowden,R., Brinkmann,K., Asselin-Labat,M.L., Phipson,B., Tanzer,M.C., Herold,M.J., Samson,A.L., Vince,J.E., Strasser,A., Pellegrini,M. and Doerflinger,M.
    Non-apoptotic caspase-8 is critical for orchestrating exaggerated inflammation during severe SARS-CoV-2 infection
    Nat Commun (2025) 16, 9822-9822. PubMed  Europe PubMed DOI  PMC  EPMC
    2. 2020
  2. Lees,A., McIntyre,A.J., Crawford,N.T., Falcone,F., McCann,C., Holohan,C., Quinn,G.P., Roberts,J.Z., Sessler,T., Gallagher,P.F., Gregg,G.M.A., McAllister,K., McLaughlin,K.M., Allen,W.L., Egan,L.J., Ryan,A.E., Labonte-Wilson,M.J., Dunne,P.D., Wappett,M., Coyle,V.M., Johnston,P.G., Kerr,E.M., Longley,D.B. and McDade,S.S.
    The pseudo-caspase FLIP(L) regulates cell fate following p53 activation
    Proc Natl Acad Sci U S A (2020) 117, 17808-17819. PubMed  Europe PubMed DOI  PMC  EPMC
  3. Smyth,P., Sessler,T., Scott,C.J. and Longley,D.B.
    FLIP(L): the pseudo-caspase
    FEBS J (2020) 287, 4246-4260. PubMed  Europe PubMed DOI
    4. 2017
  4. Nakano,H., Piao,X., Shindo,R. and Komazawa-Sakon,S.
    Cellular FLICE-inhibitory protein regulates tissue homeostasis
    Curr Top Microbiol Immunol (2017) 403, 119-141. PubMed  Europe PubMed DOI
    5. 2015
  5. Marini,E.S., Giampietri,C., Petrungaro,S., Conti,S., Filippini,A., Scorrano,L. and Ziparo,E.
    The endogenous caspase-8 inhibitor c-FLIPL regulates ER morphology and crosstalk with mitochondria
    Cell Death Differ (2015) 22, 1131-1143. PubMed  Europe PubMed DOI
    6. 2013
  6. Subramaniam,K., Hirpara,J.L., Tucker-Kellogg,L., Tucker-Kellogg,G. and Pervaiz,S.
    FLIP: A flop for execution signals
    Cancer Lett (2013) 332, 151-155. PubMed  Europe PubMed DOI
  7. Wittkopf,N., Gunther,C., Martini,E., He,G., Amann,K., He,Y.W., Schuchmann,M., Neurath,M.F. and Becker,C.
    Cellular FLICE-like inhibitory protein secures intestinal epithelial cell survival and immune homeostasis by regulating caspase-8
    Gastroenterology (2013) 145, 1369-1379. PubMed  Europe PubMed DOI  K
    8. 2011
  8. Oberst,A., Dillon,C.P., Weinlich,R., McCormick,L.L., Fitzgerald,P., Pop,C., Hakem,R., Salvesen,G.S. and Green,D.R.
    Catalytic activity of the caspase-8-FLIP(L) complex inhibits RIPK3-dependent necrosis
    Nature (2011) 471, 363-367. PubMed  Europe PubMed DOI
    9. 2006
  9. Jiang,Z. and Clemens,P.R.
    Cellular caspase-8-like inhibitory protein (cFLIP) prevents inhibition of muscle cell differentiation induced by cancer cells
    FASEB J (2006) 20, 2570-2572. PubMed  Europe PubMed DOI
    10. 2005
  10. [YEAR:1-5-2005]Dohrman,A., Kataoka,T., Cuenin,S., Russell,J.Q., Tschopp,J. and Budd,R.C.
    Cellular FLIP (long form) regulates CD8+ T cell activation through caspase-8-dependent NF-kappaB activation
    J Immunol (1-5-2005) 174, 5270-5278. PubMed  Europe PubMed
  11. Kataoka,T.
    The caspase-8 modulator c-FLIP
    Crit Rev Immunol (2005) 25, 31-58. PubMed  Europe PubMed DOI  V
  12. [YEAR:10-3-2005]Sharp,D.A., Lawrence,D.A. and Ashkenazi,A.
    Selective knockdown of the long variant of cellular FLICE inhibitory protein augments death receptor-mediated caspase-8 activation and apoptosis
    J Biol Chem (10-3-2005) 280, 19401-19409. PubMed  Europe PubMed DOI  K
    13. 2004
  13. [YEAR:21-6-2004]Boatright,K.M., Deis,C., Denault,J.B., Sutherlin,D.P. and Salvesen,G.S.
    Activation of caspases-8 and -10 by FLIP(L)
    Biochem J (21-6-2004) 382, 651-657. PubMed  Europe PubMed DOI  PMC  EPMC
  14. Thorburn,A.
    Death receptor-induced cell killing
    Cell Signal (2004) 16, 139-144. PubMed  Europe PubMed DOI
    15. 2003
  15. Jonsson,G., Paulie,S. and Grandien,A.
    High level of cFLIP correlates with resistance to death receptor-induced apoptosis in bladder carcinoma cells
    Anticancer Res (2003) 23, 1213-1218. PubMed  Europe PubMed
  16. [YEAR:3-10-2003]Li,Z., Zhang,J., Chen,D. and Shu,H.B.
    Casper/c-FLIP is physically and functionally associated with NF-kappaB1 p105
    Biochem Biophys Res Commun (3-10-2003) 309, 980-985. PubMed  Europe PubMed DOI
  17. Okano,H., Shiraki,K., Inoue,H., Kawakita,T., Yamanaka,T., Deguchi,M., Sugimoto,K., Sakai,T., Ohmori,S., Fujikawa,K., Murata,K. and Nakano,T.
    Cellular FLICE/caspase-8-inhibitory protein as a principal regulator of cell death and survival in human hepatocellular carcinoma
    Lab Invest (2003) 83, 1033-1043. PubMed  Europe PubMed DOI  R
    18. 2002
  18. Lens,S.M., Kataoka,T., Fortner,K.A., Tinel,A., Ferrero,I., MacDonald,R.H., Hahne,M., Beermann,F., Attinger,A., Orbea,H.A., Budd,R.C. and Tschopp,J.
    The caspase 8 inhibitor c-FLIP(L) modulates T-cell receptor-induced proliferation but not activation-induced cell death of lymphocytes
    Mol Cell Biol (2002) 22, 5419-5433. PubMed  Europe PubMed DOI  PMC  EPMC
  19. [YEAR:22-11-2002]Micheau,O., Thome,M., Schneider,P., Holler,N., Tschopp,J., Nicholson,D.W., Briand,C. and Grutter,M.G.
    The long form of FLIP is an activator of caspase-8 at the Fas death-inducing signaling complex
    J Biol Chem (22-11-2002) 277, 45162-45171. PubMed  Europe PubMed DOI
  20. Niikura,Y., Nonaka,T. and Imajoh-Ohmi,S.
    Monitoring of caspase-8/FLICE processing and activation upon Fas stimulation with novel antibodies directed against a cleavage site for caspase-8 and its substrate, FLICE-Like Inhibitory Protein (FLIP)
    J Biochem (2002) 132, 53-62. PubMed  Europe PubMed
    21. 1998
  21. Rasper,D.M., Vaillancourt,J.P., Hadano,S., Houtzager,V.M., Seiden,I., Keen,S.L., Tawa,P., Xanthoudakis,S., Nasir,J., Martindale,D., Koop,B.F., Peterson,E.P., Thornberry,N.A., Huang,J., MacPherson,D.P., Black,S.C., Hornung,F., Lenardo,M.J., Hayden,M.R., Roy,S. and Nicholson,D.W.
    Cell death attenuation by 'Usurpin', a mammalian DED-caspase homologue that precludes caspase-8 recruitment and activation by the CD-95 (Fas, APO-1) receptor complex
    Cell Death Differ (1998) 5, 271-288. PubMed  Europe PubMed DOI
    22. 1997
  22. Goltsev,Y.V., Kovalenko,A.V., Arnold,E., Varfolomeev,E.E., Brodianskii,V.M. and Wallach,D.
    CASH, a novel caspase homologue with death effector domains
    J Biol Chem (1997) 272, 19641-19644. PubMed  Europe PubMed DOI

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