Literature for peptidase C12.005: ubiquitinyl hydrolase-L5

(Topics flags: S Structure, P Specificity, I Inhibitor, K Knockout, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

2025
1. Jha,S., Pispa,J. and Holmberg,C.I.
   Impairment of proteasome-associated deubiquitinating enzyme Uchl5/UBH-4 affects autophagy
   Biol Open14, PubMed  Europe PubMed DOI  K
2. Jin,S.K. and Baek,K.H.
   Unraveling the role of deubiquitinating enzymes on cisplatin resistance in several cancers
   Biochim Biophys Acta Rev Cancer1880, 189297-189297. PubMed  Europe PubMed DOI  V
2024
3. Kim,H., Kim,H., Lee,S.H., Kwon,J.H., Byun,S., Yoo,J.Y., Park,S.Y. and Yoon,H.G.
   Deubiquitinase inhibitor bAP-15 suppresses renal epithelial to mesenchymal transition via inhibition of p300 stability
   Biochem Biophys Res Commun741, 151095-151095. PubMed  Europe PubMed DOI  I
4. Liu,Z., Hu,Q., Cao,K., Sun,J., Cui,L., Ji,M., Shan,W., Yang,W., Zhang,G., Tian,Z., Shi,H., Zhang,B. and Wang,R.
   Deficiency of SIAH1 promotes the formation of filopodia by increasing the accumulation of FASN in liver cancer
   Cell Death Dis15, 537-537. PubMed  Europe PubMed DOI
5. Nogami,A., Amemiya,H.J., Fujiwara,H., Umezawa,Y., Tohda,S. and Nagao,T.
   Targeting USP14/UCHL5: A Breakthrough Approach to Overcoming Treatment-Resistant FLT3-ITD-Positive AML
   Int J Mol Sci25, PubMed  Europe PubMed DOI  K  I
6. Xu,Z., Zhang,N. and Shi,L.
   Potential roles of UCH family deubiquitinases in tumorigenesis and chemical inhibitors developed against them
   Am J Cancer Res14, 2666-2694. PubMed  Europe PubMed DOI  V
2023
7. Ding,W., Wang,J.X., Wu,J.Z., Liu,A.C., Jiang,L.L., Zhang,H.C., Meng,Y., Liu,B.Y., Peng,G.J., Lou,E.Z., Mao,Q., Zhou,H., Tang,D.L., Chen,X., Liu,J.B. and Shi,X.P.
   Targeting proteasomal deubiquitinases USP14 and UCHL5 with b-AP15 reduces 5-fluorouracil resistance in colorectal cancer cells
   Acta Pharmacol Sin44, 2537-2548. PubMed  Europe PubMed DOI
8. Martinez-Fernandez,C., Jha,S., Aliagas,E., Holmberg,C.I., Nadal,E. and Ceron,J.
   BAP1 Malignant Pleural Mesothelioma Mutations in Caenorhabditis elegans Reveal Synthetic Lethality between ubh-4/BAP1 and the Proteasome Subunit rpn-9/PSMD13
   Cells12, PubMed  Europe PubMed DOI
9. Yang,X., Wang,C., Zhu,G., Guo,Z. and Fan,L.
   METTL14/YTHDF1 axis-modified UCHL5 aggravates atherosclerosis by activating the NLRP3 inflammasome
   Exp Cell Res427, 113587-113587. PubMed  Europe PubMed DOI
10. Zhu,M., Cao,Z., Mo,F., Shi,S., Hu,J., Xu,Q., Quan,K., Liang,J., Li,W., Hong,X., Zhang,B., Liu,X. and Dai,M.
    ADRM1/RPN13 attenuates cartilage extracellular matrix degradation via enhancing UCH37-mediated ALK5 deubiquitination
    Int J Biol Macromol247, 125670-125670. PubMed  Europe PubMed DOI
2022
11. Amari,K., Sasagawa,S., Imayoshi,N., Toda,Y., Hosogi,S., Imamura,T. and Ashihara,E.
    The CDK4/6-UCHL5-BRD4 axis confers resistance to BET inhibitors in MLL-rearranged leukemia cells by suppressing BRD4 protein degradation
    Biochem Biophys Res Commun588, 147-153. PubMed  Europe PubMed DOI  K
12. Cao,Y., Yan,X., Bai,X., Tang,F., Si,P., Bai,C., Tuoheti,K., Guo,L., Yisha,Z., Liu,T. and Liu,T.
    UCHL5 Promotes Proliferation and Migration of Bladder Cancer Cells by Activating c-Myc via AKT/mTOR Signaling
    Cancers (Basel)14, PubMed  Europe PubMed DOI  K
13. Du,J., Babik,S., Li,Y., Deol,K.K., Eyles,S.J., Fejzo,J., Tonelli,M. and Strieter,E.
    A cryptic K48 ubiquitin chain binding site on UCH37 is required for its role in proteasomal degradation
    elife11, PubMed  Europe PubMed DOI
14. Jiang,L., He,Q., Chen,X., Liu,A., Ding,W., Zhang,H., Chen,X., Zhou,H., Meng,Y., Liu,B., Peng,G., Wang,C., Liu,J. and Shi,X.
    Inhibition of proteasomal deubiquitinases USP14 and UCHL5 overcomes tyrosine kinase inhibitor resistance in chronic myeloid leukaemia
    Clin Transl Med12, e1038-e1038. PubMed  Europe PubMed DOI  I
15. Jiang,Z.Y., Hong,J., Zhang,J.H., Wang,X.F., Ma,Y.S., Xiong,Z.X., Sun,H.R., Cheng,C., Xie,B.Z., Liu,J.B., Ouyang,Y.G. and Fu,D.
    Treatment with b-AP15 to Inhibit UCHL5 and USP14 Deubiquitinating Activity and Enhance p27 and Cyclin E1 for Tumors with p53 Deficiency
    Technol Cancer Res Treat21, 15330338221119745-15330338221119745. PubMed  Europe PubMed DOI  I
16. van der Wal,L., Bezstarosti,K. and Demmers,J.A.A.
    A ubiquitinome analysis to study the functional roles of the proteasome associated deubiquitinating enzymes USP14 and UCH37
    J Proteomics262, 104592-104592. PubMed  Europe PubMed DOI  I
17. Yang,Y., Cao,L., Guo,Z., Gu,H., Zhang,K. and Qiu,Z.
    Deubiquitinase UCHL5 stabilizes ELK3 to potentiate cancer stemness and tumor progression in pancreatic adenocarcinoma (PAAD)
    Exp Cell Res421, 113402-113402. PubMed  Europe PubMed DOI  I
2021
18. Barban do Patrocinio,A., Cabral,F.J., de Paiva,T.H., Magalhaes,L.G., Paula,L.A.L., Brigato,O.M., Guerra-Sa,R. and Rodrigues,V.
    Deubiquitinating enzymes as possible drug targets for schistosomiasis
    Acta Trop217, 105856-105856. PubMed  Europe PubMed DOI  I
19. Moon,S., Muniyappan,S., Lee,S.B. and Lee,B.H.
    Small-Molecule Inhibitors Targeting Proteasome-Associated Deubiquitinases
    Int J Mol Sci22, 6213-6213. PubMed  Europe PubMed DOI  I
20. Ramachandran,A., Kumar,B., Waris,G. and Everly,D.
    Deubiquitination and Activation of the NLRP3 Inflammasome by UCHL5 in HCV-Infected Cells
    Microbiol Spectr9, e0075521-e0075521. PubMed  Europe PubMed DOI
21. Song,A., Hazlett,Z., Abeykoon,D., Dortch,J., Dillon,A., Curtiss,J., Martinez,S.B., Hill,C.P., Yu,C., Huang,L., Fushman,D., Cohen,R.E. and Yao,T.
    Branched ubiquitin chain binding and deubiquitination by UCH37 facilitate proteasome clearance of stress-induced inclusions
    elife10, PubMed  Europe PubMed DOI
2020
22. Deol,K.K., Crowe,S.O., Du,J., Bisbee,H.A., Guenette,R.G. and Strieter,E.R.
    Proteasome-Bound UCH37/UCHL5 Debranches Ubiquitin Chains to Promote Degradation
    Mol Cell PubMed  Europe PubMed DOI
23. Gurusingha Arachchige,H.S., Herath Mudiyanselage,P.D.H., VanHecke,G.C., Patel,K., Cheaito,H.A., Dou,Q.P. and Ahn,Y.H.
    Synthesis and evaluation of tiaprofenic acid-derived UCHL5 deubiquitinase inhibitors
    Bioorg Med Chem30, 115931-115931. PubMed  Europe PubMed DOI  I
24. Liu,D., Song,Z., Wang,X. and Ouyang,L.
    Ubiquitin C-Terminal Hydrolase L5 (UCHL5) Accelerates the Growth of Endometrial Cancer via Activating the Wnt/beta-Catenin Signaling Pathway
    Front Oncol10, 865-865. PubMed  Europe PubMed DOI  K
25. Ma,Y.S., Wang,X.F., Yu,F., Wu,T.M., Liu,J.B., Zhang,Y.J., Xia,Q., Jiang,Z.Y., Lin,Q.L. and Fu,D.
    Inhibition of USP14 and UCH37 deubiquitinating activity by b-AP15 as a potential therapy for tumors with p53 deficiency
    Signal Transduct Target Ther5, 30-30. PubMed  Europe PubMed DOI  I
26. Osei-Amponsa,V., Sridharan,V., Tandon,M., Evans,C.N., Klarmann,K., Cheng,K.T., Lack,J., Chari,R. and Walters,K.J.
    Impact of losing hRpn13 Pru or UCHL5 on proteasome clearance of ubiquitinated proteins and RA190 cytotoxicity
    Mol Cell Biol PubMed  Europe PubMed DOI
27. Shin,J.Y., Muniyappan,S., Tran,N.N., Park,H., Lee,S.B. and Lee,B.H.
    Deubiquitination Reactions on the Proteasome for Proteasome Versatility
    Int J Mol Sci21, 5312-5312. PubMed  Europe PubMed DOI
28. Sriramoju,M.K., Chen,Y. and Hsu,S.D.
    Protein knots provide mechano-resilience to an AAA+ protease-mediated proteolysis with profound ATP energy expenses
    Biochim Biophys Acta Proteins Proteom1868, 140330-140330. PubMed  Europe PubMed DOI
2019
29. Castro,I., Ekinci,E., Huang,X., Cheaito,H.A., Ahn,Y.H., Olivero-Verbel,J. and Dou,Q.P.
    Proteasome-associated cysteine deubiquitinases are molecular targets of environmental optical brightener compounds
    J Cell Biochem120, 14065-14075. PubMed  Europe PubMed DOI
30. Chadchankar,J., Korboukh,V., Conway,L.C., Wobst,H.J., Walker,C.A., Doig,P., Jacobsen,S.J., Brandon,N.J., Moss,S.J. and Wang,Q.
    Inactive USP14 and inactive UCHL5 cause accumulation of distinct ubiquitinated proteins in mammalian cells
    PLoS ONE14, e0225145-e0225145. PubMed  Europe PubMed DOI
2018
31. Ahmed,Z.S.O., Li,X., Li,F., Cheaito,H.A., Patel,K., Mosallam,E.M., Elbargeesy,G.A.E.H. and Dou,Q.P.
    Computational and biochemical studies of isothiocyanates as inhibitors of proteasomal cysteine deubiquitinases in human cancer cells
    J Cell Biochem119, 9006-9016. PubMed  Europe PubMed DOI  I
32. Han,K., Dai,Y., Zhang,Z., Zou,Z. and Wang,Y.
    Molecular characterization and expression profiles of Sp-uchl3 and Sp-uchl5 during gonad development of Scylla paramamosain
    Molecules23, PubMed  Europe PubMed DOI
2017
33. Chen,X., Yang,Q., Xiao,L., Tang,D., Dou,Q.P. and Liu,J.
    Metal-based proteasomal deubiquitinase inhibitors as potential anticancer agents
    Cancer Metastasis Rev36, 655-668. PubMed  Europe PubMed DOI  I
34. De Poot,S.A.H., Tian,G. and Finley,D.
    Meddling with fate: the proteasomal deubiquitinating enzymes
    J Mol Biol429, 3525-3545. PubMed  Europe PubMed DOI
35. Han,W., Lee,H. and Han,J.K.
    Ubiquitin C-terminal hydrolase37 regulates Tcf7 DNA binding for the activation of Wnt signalling
    Sci Rep7, 42590-42590. PubMed  Europe PubMed DOI
36. Hanpude,P., Bhattacharya,S., Singh,A.K. and Maiti,T.K.
    Ubiquitin recognition of BAP1: understanding its enzymatic function
    Biosci Rep37, BSR20171099-BSR20171099. PubMed  Europe PubMed DOI
37. Lee,J.H. and Lee,M.J.
    Isolation and characterization of RNA aptamers against a proteasome-associated deubiquitylating enzyme UCH37
    Chembiochem18, 171-175. PubMed  Europe PubMed DOI  I
38. Lee,Y.C., Chang,C.Y., Chen,S.Y., Pan,Y.R., Ho,M.R. and Hsu,S.D.
    Entropic stabilization of a deubiquitinase provides conformational plasticity and slow unfolding kinetics beneficial for functioning on the proteasome
    Sci Rep7, 45174-45174. PubMed  Europe PubMed DOI
2016
39. Nan,L., Jacko,A.M., Tan,J., Wang,D., Zhao,J., Kass,D.J., Ma,H. and Zhao,Y.
    Ubiquitin carboxyl-terminal hydrolase-L5 promotes TGFbeta-1 signaling by de-ubiquitinating and stabilizing Smad2/Smad3 in pulmonary fibrosis
    Sci Rep6, 33116-33116. PubMed  Europe PubMed DOI
40. Randles,L., Anchoori,R.K., Roden,R.B. and Walters,K.J.
    The proteasome ubiquitin receptor hRpn13 and its interacting deubiquitinating enzyme Uch37 are required for proper cell cycle progression
    J Biol Chem291, 8773-8783. PubMed  Europe PubMed DOI
41. Zhao,C., Chen,X., Zang,D., Lan,X., Liao,S., Yang,C., Zhang,P., Wu,J., Li,X., Liu,N., Liao,Y., Huang,H., Shi,X., Jiang,L., Liu,X., He,Z., Dou,Q.P., Wang,X. and Liu,J.
    A novel nickel complex works as a proteasomal deubiquitinase inhibitor for cancer therapy
    Oncogene35, 5916-5927. PubMed  Europe PubMed DOI  I
2015
42. D'Arcy,P., Wang,X. and Linder,S.
    Deubiquitinase inhibition as a cancer therapeutic strategy
    Pharmacol Ther147C, 32-54. PubMed  Europe PubMed DOI  I
43. Lawson,A.P., Long,M.J., Coffey,R.T., Qian,Y., Weerapana,E., El Oualid,F. and Hedstrom,L.
    Naturally occurring isothiocyanates exert anticancer effects by inhibiting deubiquitinating enzymes
    Cancer Res75, 5130-5142. PubMed  Europe PubMed DOI  I
44. Sahtoe,D.D., van Dijk,W.J., El Oualid,F., Ekkebus,R., Ovaa,H. and Sixma,T.K.
    Mechanism of UCH-L5 activation and inhibition by DEUBAD domains in RPN13 and INO80G
    Mol Cell57, 887-900. PubMed  Europe PubMed DOI  S
45. Selvaraju,K., Mazurkiewicz,M., Wang,X., Gullbo,J., Linder,S. and D'Arcy,P.
    Inhibition of proteasome deubiquitinase activity: a strategy to overcome resistance to conventional proteasome inhibitors?
    Drug Resist Updat21-22, 20-29. PubMed  Europe PubMed DOI
46. VanderLinden,R.T., Hemmis,C.W., Schmitt,B., Ndoja,A., Whitby,F.G., Robinson,H., Cohen,R.E., Yao,T. and Hill,C.P.
    Structural basis for the activation and inhibition of the UCH37 deubiquitylase
    Mol Cell57, 901-911. PubMed  Europe PubMed DOI  S
2014
47. Jiao,L., Ouyang,S., Shaw,N., Song,G., Feng,Y., Niu,F., Qiu,W., Zhu,H., Hung,L.W., Zuo,X., Eleonora Shtykova,V., Zhu,P., Dong,Y.H., Xu,R. and Liu,Z.J.
    Mechanism of the Rpn13-induced activation of Uch37
    Protein Cell5, 616-630. PubMed  Europe PubMed DOI
48. Liu,N., Li,X., Huang,H., Zhao,C., Liao,S., Yang,C., Liu,S., Song,W., Lu,X., Lan,X., Chen,X., Yi,S., Xu,L., Jiang,L., Zhao,C., Dong,X., Zhou,P., Li,S., Wang,S., Shi,X., Dou,P.Q., Wang,X. and Liu,J.
    Clinically used antirheumatic agent auranofin is a proteasomal deubiquitinase inhibitor and inhibits tumor growth
    Oncotarget5, 5453-5471. PubMed  Europe PubMed  I
49. Tian,Z., D'Arcy,P., Wang,X., Ray,A., Tai,Y.T., Hu,Y., Carrasco,R.D., Richardson,P., Linder,S., Chauhan,D. and Anderson,K.C.
    A novel small molecule inhibitor of deubiquitylating enzyme USP14 and UCHL5 induces apoptosis in multiple myeloma and overcomes bortezomib resistance
    Blood123, 706-716. PubMed  Europe PubMed DOI  I
2013
50. Chen,Y.J., Ma,Y.S., Fang,Y., Wang,Y., Fu,D. and Shen,X.Z.
    Power and promise of ubiquitin carboxyl-terminal hydrolase 37 as a target of cancer therapy
    Asian Pac J Cancer Prev14, 2173-2179. PubMed  Europe PubMed
51. Ko,Y.M., Chang,C.Y., Chiou,S.J., Hsu,F.J., Huang,J.S., Yang,Y.L., Guh,J.Y. and Chuang,L.Y.
    Ubiquitin C-terminal hydrolase-L5 is required for high glucose-induced transforming growth factor-beta receptor I expression and hypertrophy in mesangial cells
    Arch Biochem Biophys535, 177-186. PubMed  Europe PubMed DOI
52. Morrow,M.E., Kim,M.I., Ronau,J.A., Sheedlo,M.J., White,R.R., Chaney,J., Paul,L.N., Lill,M.A., Artavanis-Tsakonas,K. and Das,C.
    Stabilization of an unusual salt bridge in ubiquitin by the extra C-terminal domain of the proteasome-associated deubiquitinase UCH37 as a mechanism of its exo specificity
    Biochemistry52, 3564-3578. PubMed  Europe PubMed DOI
53. Peth,A., Kukushkin,N., Bosse,M. and Goldberg,A.L.
    Ubiquitinated proteins activate the proteasomal ATPases by binding to Usp14 or Uch37 homologs
    J Biol Chem288, 7781-7790. PubMed  Europe PubMed DOI
2012
54. Iphofer,A., Kummer,A., Nimtz,M., Ritter,A., Arnold,T., Frank,R., van den Heuvel,J., Kessler,B.M., Jansch,L. and Franke,R.
    Profiling ubiquitin linkage specificities of deubiquitinating enzymes with branched ubiquitin isopeptide probes
    Chembiochem13, 1416-1420. PubMed  Europe PubMed DOI  P
55. Yao,T.
    Ubiquitin carboxyl-terminal hydrolase 37
    [ISSN:978-0-12-407743-0]3, 2043-2049. DOI
56. Zhou,Z.R., Zhang,Y.H., Liu,S., Song,A.X. and Hu,H.Y.
    Length of the active-site crossover loop defines the substrate specificity of ubiquitin C-terminal hydrolases for ubiquitin chains
    Biochem J441, 143-149. PubMed  Europe PubMed DOI
2011
57. D'Arcy,P., Brnjic,S., Olofsson,M.H., Fryknas,M., Lindsten,K., De Cesare,M., Perego,P., Sadeghi,B., Hassan,M., Larsson,R. and Linder,S.
    Inhibition of proteasome deubiquitinating activity as a new cancer therapy
    Nat Med17, 1636-1640. PubMed  Europe PubMed DOI  I
58. Lee,M.J., Lee,B.H., Hanna,J., King,R.W. and Finley,D.
    Trimming of ubiquitin chains by proteasome-associated deubiquitinating enzymes
    Mol Cell Proteomics10, R110-R110. PubMed  Europe PubMed DOI  P
59. Maiti,T.K., Permaul,M., Boudreaux,D.A., Mahanic,C., Mauney,S. and Das,C.
    Crystal structure of the catalytic domain of UCHL5, a proteasome-associated human deubiquitinating enzyme, reveals an unproductive form of the enzyme
    FEBS J278, 4917-4926. PubMed  Europe PubMed DOI  S
60. White,R.R., Miyata,S., Papa,E., Spooner,E., Gounaris,K., Selkirk,M.E. and Artavanis-Tsakonas,K.
    Characterisation of the Trichinella spiralis deubiquitinating enzyme, TsUCH37, an evolutionarily conserved proteasome interaction partner
    PLoS Negl Trop Dis5, e1340-e1340. PubMed  Europe PubMed DOI
2010
61. Yeh,H.Y. and Klesius,P.H.
    Characterization and tissue expression of channel catfish (Ictalurus punctatus Rafinesque, 1818) ubiquitin carboxyl-terminal hydrolase L5 (UCHL5) cDNA
    Mol Biol Rep37, 1229-1234. PubMed  Europe PubMed DOI
2009
62. Nishio,K., Kim,S.W., Kawai,K., Mizushima,T., Yamane,T., Hamazaki,J., Murata,S., Tanaka,K. and Morimoto,Y.
    Crystal structure of the de-ubiquitinating enzyme UCH37 (human UCH-L5) catalytic domain
    Biochem Biophys Res Commun390, 855-860. PubMed  Europe PubMed DOI  S
2008
63. Koulich,E., Li,X. and DeMartino,G.N.
    Relative structural and functional roles of multiple deubiquitylating proteins associated with mammalian 26S proteasome
    Mol Biol Cell19, 1072-1082. PubMed  Europe PubMed DOI
64. Yao,T., Song,L., Jin,J., Cai,Y., Takahashi,H., Swanson,S.K., Washburn,M.P., Florens,L., Conaway,R.C., Cohen,R.E. and Conaway,J.W.
    Distinct modes of regulation of the Uch37 deubiquitinating enzyme in the proteasome and in the Ino80 chromatin-remodeling complex
    Mol Cell31, 909-917. PubMed  Europe PubMed DOI
2006
65. [YEAR:21-9-2006]Hamazaki,J., Iemura,S., Natsume,T., Yashiroda,H., Tanaka,K. and Murata,S.
    A novel proteasome interacting protein recruits the deubiquitinating enzyme UCH37 to 26S proteasomes
    EMBO J25, 4524-4536. PubMed  Europe PubMed DOI
66. Qiu,X.B., Ouyang,S.Y., Li,C.J., Miao,S., Wang,L. and Goldberg,A.L.
    hRpn13/ADRM1/GP110 is a novel proteasome subunit that binds the deubiquitinating enzyme, UCH37
    EMBO J25, 5742-5753. PubMed  Europe PubMed DOI
67. Wicks,S.J., Grocott,T., Haros,K., Maillard,M., ten Dijke,P. and Chantry,A.
    Reversible ubiquitination regulates the Smad/TGF-beta signalling pathway
    Biochem Soc Trans34, 761-763. PubMed  Europe PubMed DOI
68. [YEAR:13-8-2006]Yao,T., Song,L., Xu,W., DeMartino,G.N., Florens,L., Swanson,S.K., Washburn,M.P., Conaway,R.C., Conaway,J.W. and Cohen,R.E.
    Proteasome recruitment and activation of the Uch37 deubiquitinating enzyme by Adrm1
    Nat Cell Biol8, 994-1002. PubMed  Europe PubMed DOI
2005
69. [YEAR:18-7-2005]Wicks,S.J., Haros,K., Maillard,M., Song,L., Cohen,R.E., Dijke,P.T. and Chantry,A.
    The deubiquitinating enzyme UCH37 interacts with Smads and regulates TGF-beta signalling
    Oncogene24, 8080-8084. PubMed  Europe PubMed DOI
2000
70. [YEAR:10-7-2000]Holzl,H., Kapelari,B., Kellermann,J., Seemuller,E., Sumegi,M., Udvardy,A., Medalia,O., Sperling,J., Muller,S.A., Engel,A. and Baumeister,W.
    The regulatory complex of Drosophila melanogaster 26S proteasomes. Subunit composition and localization of a deubiquitylating enzyme
    J Cell Biol150, 119-130. PubMed  Europe PubMed DOI