Literature for peptidase C12.005: ubiquitinyl hydrolase-L5

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

(Topics flags: S Structure, P Specificity, I Inhibitor, K Knockout, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

2025

Fu,C., Saddawi-Konefka,R., Chinai,J.M., Kim,S.Y., Kammula,A.V., Perera,J.J., Jiang,A., Tiwari,P., Kistler,E.N., Tang,S., Luna,S.M., Colvin,K.J., Dubrot,J., Anderson,S., Fetterman,R.A., Chuong,C.L., Lane-Reticker,S.K., Cheruiyot,C.K., Muscato,A.J., Alipour,Z., Adkins,D.R., Griffin,G.K., Bernstein,B.E., Egloff,A.M., Yates,K.B., Chernock,R.D., Gutkind,J.S., Uppaluri,R. and Manguso,R.T. In vivo CRISPR screening in head and neck cancer reveals Uchl5 as an immunotherapy target Nat Commun (2025) 16, 8572-8572. PubMed Europe PubMed DOI PMC EPMC
Jha,S., Pispa,J. and Holmberg,C.I. Impairment of proteasome-associated deubiquitinating enzyme Uchl5/UBH-4 affects autophagy Biol Open (2025) 14 PubMed Europe PubMed DOI K
Jin,S.K. and Baek,K.H. Unraveling the role of deubiquitinating enzymes on cisplatin resistance in several cancers Biochim Biophys Acta Rev Cancer (2025) 1880, 189297-189297. PubMed Europe PubMed DOI V
Zhang,S., Han,B., Jiang,B., Chen,M., Mu,D., Wang,Q., Sun,S., Xu,T., Song,F., Ren,X., Pan,Z., Huang,P. and Ge,M. USP14 and UCHL5 synergistically deubiquitinate PKCalpha and translocate NF-kappaB to promote the progression of anaplastic thyroid cancer Cell Death Dis (2025) 16, 617-617. PubMed Europe PubMed DOI PMC EPMC K

2024

Kim,H., Kim,H., Lee,S.H., Kwon,J.H., Byun,S., Yoo,J.Y., Park,S.Y. and Yoon,H.G. Deubiquitinase inhibitor bAP-15 suppresses renal epithelial to mesenchymal transition via inhibition of p300 stability Biochem Biophys Res Commun (2024) 741, 151095-151095. PubMed Europe PubMed DOI I
Liu,Z., Hu,Q., Cao,K., Sun,J., Cui,L., Ji,M., Shan,W., Yang,W., Zhang,G., Tian,Z., Shi,H., Zhang,B. and Wang,R. Deficiency of SIAH1 promotes the formation of filopodia by increasing the accumulation of FASN in liver cancer Cell Death Dis (2024) 15, 537-537. PubMed Europe PubMed DOI PMC EPMC
Nogami,A., Amemiya,H.J., Fujiwara,H., Umezawa,Y., Tohda,S. and Nagao,T. Targeting USP14/UCHL5: A Breakthrough Approach to Overcoming Treatment-Resistant FLT3-ITD-Positive AML Int J Mol Sci (2024) 25 PubMed Europe PubMed DOI PMC EPMC K I
Xu,Z., Zhang,N. and Shi,L. Potential roles of UCH family deubiquitinases in tumorigenesis and chemical inhibitors developed against them Am J Cancer Res (2024) 14, 2666-2694. PubMed Europe PubMed DOI PMC EPMC V

2023

Ding,W., Wang,J.X., Wu,J.Z., Liu,A.C., Jiang,L.L., Zhang,H.C., Meng,Y., Liu,B.Y., Peng,G.J., Lou,E.Z., Mao,Q., Zhou,H., Tang,D.L., Chen,X., Liu,J.B. and Shi,X.P. Targeting proteasomal deubiquitinases USP14 and UCHL5 with b-AP15 reduces 5-fluorouracil resistance in colorectal cancer cells Acta Pharmacol Sin (2023) 44, 2537-2548. PubMed Europe PubMed DOI
Martinez-Fernandez,C., Jha,S., Aliagas,E., Holmberg,C.I., Nadal,E. and Ceron,J. BAP1 Malignant Pleural Mesothelioma Mutations in Caenorhabditis elegans Reveal Synthetic Lethality between ubh-4/BAP1 and the Proteasome Subunit rpn-9/PSMD13 Cells (2023) 12 PubMed Europe PubMed DOI PMC EPMC
Yang,X., Wang,C., Zhu,G., Guo,Z. and Fan,L. METTL14/YTHDF1 axis-modified UCHL5 aggravates atherosclerosis by activating the NLRP3 inflammasome Exp Cell Res (2023) 427, 113587-113587. PubMed Europe PubMed DOI
Zhu,M., Cao,Z., Mo,F., Shi,S., Hu,J., Xu,Q., Quan,K., Liang,J., Li,W., Hong,X., Zhang,B., Liu,X. and Dai,M. ADRM1/RPN13 attenuates cartilage extracellular matrix degradation via enhancing UCH37-mediated ALK5 deubiquitination Int J Biol Macromol (2023) 247, 125670-125670. PubMed Europe PubMed DOI

2022

Amari,K., Sasagawa,S., Imayoshi,N., Toda,Y., Hosogi,S., Imamura,T. and Ashihara,E. The CDK4/6-UCHL5-BRD4 axis confers resistance to BET inhibitors in MLL-rearranged leukemia cells by suppressing BRD4 protein degradation Biochem Biophys Res Commun (2022) 588, 147-153. PubMed Europe PubMed DOI K
Cao,Y., Yan,X., Bai,X., Tang,F., Si,P., Bai,C., Tuoheti,K., Guo,L., Yisha,Z., Liu,T. and Liu,T. UCHL5 Promotes Proliferation and Migration of Bladder Cancer Cells by Activating c-Myc via AKT/mTOR Signaling Cancers (Basel) (2022) 14 PubMed Europe PubMed DOI PMC EPMC K
Du,J., Babik,S., Li,Y., Deol,K.K., Eyles,S.J., Fejzo,J., Tonelli,M. and Strieter,E. A cryptic K48 ubiquitin chain binding site on UCH37 is required for its role in proteasomal degradation elife (2022) 11 PubMed Europe PubMed DOI PMC EPMC
Jiang,L., He,Q., Chen,X., Liu,A., Ding,W., Zhang,H., Chen,X., Zhou,H., Meng,Y., Liu,B., Peng,G., Wang,C., Liu,J. and Shi,X. Inhibition of proteasomal deubiquitinases USP14 and UCHL5 overcomes tyrosine kinase inhibitor resistance in chronic myeloid leukaemia Clin Transl Med (2022) 12, e1038-e1038. PubMed Europe PubMed DOI PMC EPMC I
Jiang,Z.Y., Hong,J., Zhang,J.H., Wang,X.F., Ma,Y.S., Xiong,Z.X., Sun,H.R., Cheng,C., Xie,B.Z., Liu,J.B., Ouyang,Y.G. and Fu,D. Treatment with b-AP15 to Inhibit UCHL5 and USP14 Deubiquitinating Activity and Enhance p27 and Cyclin E1 for Tumors with p53 Deficiency Technol Cancer Res Treat (2022) 21, 15330338221119745-15330338221119745. PubMed Europe PubMed DOI PMC EPMC I
van der Wal,L., Bezstarosti,K. and Demmers,J.A.A. A ubiquitinome analysis to study the functional roles of the proteasome associated deubiquitinating enzymes USP14 and UCH37 J Proteomics (2022) 262, 104592-104592. PubMed Europe PubMed DOI I
Wang,S., Wang,T., Yang,Q., Cheng,S., Liu,F., Yang,G., Wang,F., Wang,R., Yang,D., Zhou,M., Duan,C., Zhang,Y., Liu,H., Dai,Z., Tian,K. and Liu,S. Proteasomal deubiquitylase activity enhances cell surface recycling of the epidermal growth factor receptor in non-small cell lung cancer Cell Oncol (Dordr) (2022) 45, 951-965. PubMed Europe PubMed DOI I
Yang,Y., Cao,L., Guo,Z., Gu,H., Zhang,K. and Qiu,Z. Deubiquitinase UCHL5 stabilizes ELK3 to potentiate cancer stemness and tumor progression in pancreatic adenocarcinoma (PAAD) Exp Cell Res (2022) 421, 113402-113402. PubMed Europe PubMed DOI I

2021

Barban do Patrocinio,A., Cabral,F.J., de Paiva,T.H., Magalhaes,L.G., Paula,L.A.L., Brigato,O.M., Guerra-Sa,R. and Rodrigues,V. Deubiquitinating enzymes as possible drug targets for schistosomiasis Acta Trop (2021) 217, 105856-105856. PubMed Europe PubMed DOI I
Moon,S., Muniyappan,S., Lee,S.B. and Lee,B.H. Small-Molecule Inhibitors Targeting Proteasome-Associated Deubiquitinases Int J Mol Sci (2021) 22, 6213-6213. PubMed Europe PubMed DOI PMC EPMC I
Ramachandran,A., Kumar,B., Waris,G. and Everly,D. Deubiquitination and Activation of the NLRP3 Inflammasome by UCHL5 in HCV-Infected Cells Microbiol Spectr (2021) 9, e0075521-e0075521. PubMed Europe PubMed DOI
Song,A., Hazlett,Z., Abeykoon,D., Dortch,J., Dillon,A., Curtiss,J., Martinez,S.B., Hill,C.P., Yu,C., Huang,L., Fushman,D., Cohen,R.E. and Yao,T. Branched ubiquitin chain binding and deubiquitination by UCH37 facilitate proteasome clearance of stress-induced inclusions elife (2021) 10 PubMed Europe PubMed DOI PMC EPMC

2020

Deol,K.K., Crowe,S.O., Du,J., Bisbee,H.A., Guenette,R.G. and Strieter,E.R. Proteasome-Bound UCH37/UCHL5 Debranches Ubiquitin Chains to Promote Degradation Mol Cell (2020) PubMed Europe PubMed DOI
Gurusingha Arachchige,H.S., Herath Mudiyanselage,P.D.H., VanHecke,G.C., Patel,K., Cheaito,H.A., Dou,Q.P. and Ahn,Y.H. Synthesis and evaluation of tiaprofenic acid-derived UCHL5 deubiquitinase inhibitors Bioorg Med Chem (2020) 30, 115931-115931. PubMed Europe PubMed DOI I
Liu,D., Song,Z., Wang,X. and Ouyang,L. Ubiquitin C-Terminal Hydrolase L5 (UCHL5) Accelerates the Growth of Endometrial Cancer via Activating the Wnt/beta-Catenin Signaling Pathway Front Oncol (2020) 10, 865-865. PubMed Europe PubMed DOI PMC EPMC K
Ma,Y.S., Wang,X.F., Yu,F., Wu,T.M., Liu,J.B., Zhang,Y.J., Xia,Q., Jiang,Z.Y., Lin,Q.L. and Fu,D. Inhibition of USP14 and UCH37 deubiquitinating activity by b-AP15 as a potential therapy for tumors with p53 deficiency Signal Transduct Target Ther (2020) 5, 30-30. PubMed Europe PubMed DOI PMC EPMC I
Osei-Amponsa,V., Sridharan,V., Tandon,M., Evans,C.N., Klarmann,K., Cheng,K.T., Lack,J., Chari,R. and Walters,K.J. Impact of losing hRpn13 Pru or UCHL5 on proteasome clearance of ubiquitinated proteins and RA190 cytotoxicity Mol Cell Biol (2020) PubMed Europe PubMed DOI
Shin,J.Y., Muniyappan,S., Tran,N.N., Park,H., Lee,S.B. and Lee,B.H. Deubiquitination Reactions on the Proteasome for Proteasome Versatility Int J Mol Sci (2020) 21, 5312-5312. PubMed Europe PubMed DOI
Sriramoju,M.K., Chen,Y. and Hsu,S.D. Protein knots provide mechano-resilience to an AAA+ protease-mediated proteolysis with profound ATP energy expenses Biochim Biophys Acta Proteins Proteom (2020) 1868, 140330-140330. PubMed Europe PubMed DOI

2019

Castro,I., Ekinci,E., Huang,X., Cheaito,H.A., Ahn,Y.H., Olivero-Verbel,J. and Dou,Q.P. Proteasome-associated cysteine deubiquitinases are molecular targets of environmental optical brightener compounds J Cell Biochem (2019) 120, 14065-14075. PubMed Europe PubMed DOI
Chadchankar,J., Korboukh,V., Conway,L.C., Wobst,H.J., Walker,C.A., Doig,P., Jacobsen,S.J., Brandon,N.J., Moss,S.J. and Wang,Q. Inactive USP14 and inactive UCHL5 cause accumulation of distinct ubiquitinated proteins in mammalian cells PLoS ONE (2019) 14, e0225145-e0225145. PubMed Europe PubMed DOI PMC EPMC

2018

Ahmed,Z.S.O., Li,X., Li,F., Cheaito,H.A., Patel,K., Mosallam,E.M., Elbargeesy,G.A.E.H. and Dou,Q.P. Computational and biochemical studies of isothiocyanates as inhibitors of proteasomal cysteine deubiquitinases in human cancer cells J Cell Biochem (2018) 119, 9006-9016. PubMed Europe PubMed DOI I
Han,K., Dai,Y., Zhang,Z., Zou,Z. and Wang,Y. Molecular characterization and expression profiles of Sp-uchl3 and Sp-uchl5 during gonad development of Scylla paramamosain Molecules (2018) 23 PubMed Europe PubMed DOI

2017

Chen,X., Yang,Q., Xiao,L., Tang,D., Dou,Q.P. and Liu,J. Metal-based proteasomal deubiquitinase inhibitors as potential anticancer agents Cancer Metastasis Rev (2017) 36, 655-668. PubMed Europe PubMed DOI I
De Poot,S.A.H., Tian,G. and Finley,D. Meddling with fate: the proteasomal deubiquitinating enzymes J Mol Biol (2017) 429, 3525-3545. PubMed Europe PubMed DOI
Han,W., Lee,H. and Han,J.K. Ubiquitin C-terminal hydrolase37 regulates Tcf7 DNA binding for the activation of Wnt signalling Sci Rep (2017) 7, 42590-42590. PubMed Europe PubMed DOI PMC EPMC
Hanpude,P., Bhattacharya,S., Singh,A.K. and Maiti,T.K. Ubiquitin recognition of BAP1: understanding its enzymatic function Biosci Rep (2017) 37, BSR20171099-BSR20171099. PubMed Europe PubMed DOI
Lee,J.H. and Lee,M.J. Isolation and characterization of RNA aptamers against a proteasome-associated deubiquitylating enzyme UCH37 Chembiochem (2017) 18, 171-175. PubMed Europe PubMed DOI I
Lee,Y.C., Chang,C.Y., Chen,S.Y., Pan,Y.R., Ho,M.R. and Hsu,S.D. Entropic stabilization of a deubiquitinase provides conformational plasticity and slow unfolding kinetics beneficial for functioning on the proteasome Sci Rep (2017) 7, 45174-45174. PubMed Europe PubMed DOI PMC EPMC

2016

Nan,L., Jacko,A.M., Tan,J., Wang,D., Zhao,J., Kass,D.J., Ma,H. and Zhao,Y. Ubiquitin carboxyl-terminal hydrolase-L5 promotes TGFbeta-1 signaling by de-ubiquitinating and stabilizing Smad2/Smad3 in pulmonary fibrosis Sci Rep (2016) 6, 33116-33116. PubMed Europe PubMed DOI PMC EPMC
Randles,L., Anchoori,R.K., Roden,R.B. and Walters,K.J. The proteasome ubiquitin receptor hRpn13 and its interacting deubiquitinating enzyme Uch37 are required for proper cell cycle progression J Biol Chem (2016) 291, 8773-8783. PubMed Europe PubMed DOI
Zhao,C., Chen,X., Zang,D., Lan,X., Liao,S., Yang,C., Zhang,P., Wu,J., Li,X., Liu,N., Liao,Y., Huang,H., Shi,X., Jiang,L., Liu,X., He,Z., Dou,Q.P., Wang,X. and Liu,J. A novel nickel complex works as a proteasomal deubiquitinase inhibitor for cancer therapy Oncogene (2016) 35, 5916-5927. PubMed Europe PubMed DOI I

2015

D'Arcy,P., Wang,X. and Linder,S. Deubiquitinase inhibition as a cancer therapeutic strategy Pharmacol Ther (2015) 147C, 32-54. PubMed Europe PubMed DOI I
Lawson,A.P., Long,M.J., Coffey,R.T., Qian,Y., Weerapana,E., El Oualid,F. and Hedstrom,L. Naturally occurring isothiocyanates exert anticancer effects by inhibiting deubiquitinating enzymes Cancer Res (2015) 75, 5130-5142. PubMed Europe PubMed DOI I
Sahtoe,D.D., van Dijk,W.J., El Oualid,F., Ekkebus,R., Ovaa,H. and Sixma,T.K. Mechanism of UCH-L5 activation and inhibition by DEUBAD domains in RPN13 and INO80G Mol Cell (2015) 57, 887-900. PubMed Europe PubMed DOI PMC EPMC S
Selvaraju,K., Mazurkiewicz,M., Wang,X., Gullbo,J., Linder,S. and D'Arcy,P. Inhibition of proteasome deubiquitinase activity: a strategy to overcome resistance to conventional proteasome inhibitors? Drug Resist Updat (2015) 21-22, 20-29. PubMed Europe PubMed DOI
VanderLinden,R.T., Hemmis,C.W., Schmitt,B., Ndoja,A., Whitby,F.G., Robinson,H., Cohen,R.E., Yao,T. and Hill,C.P. Structural basis for the activation and inhibition of the UCH37 deubiquitylase Mol Cell (2015) 57, 901-911. PubMed Europe PubMed DOI PMC EPMC S

2014

Jiao,L., Ouyang,S., Shaw,N., Song,G., Feng,Y., Niu,F., Qiu,W., Zhu,H., Hung,L.W., Zuo,X., Eleonora Shtykova,V., Zhu,P., Dong,Y.H., Xu,R. and Liu,Z.J. Mechanism of the Rpn13-induced activation of Uch37 Protein Cell (2014) 5, 616-630. PubMed Europe PubMed DOI
Liu,N., Li,X., Huang,H., Zhao,C., Liao,S., Yang,C., Liu,S., Song,W., Lu,X., Lan,X., Chen,X., Yi,S., Xu,L., Jiang,L., Zhao,C., Dong,X., Zhou,P., Li,S., Wang,S., Shi,X., Dou,P.Q., Wang,X. and Liu,J. Clinically used antirheumatic agent auranofin is a proteasomal deubiquitinase inhibitor and inhibits tumor growth Oncotarget (2014) 5, 5453-5471. PubMed Europe PubMed I
Tian,Z., D'Arcy,P., Wang,X., Ray,A., Tai,Y.T., Hu,Y., Carrasco,R.D., Richardson,P., Linder,S., Chauhan,D. and Anderson,K.C. A novel small molecule inhibitor of deubiquitylating enzyme USP14 and UCHL5 induces apoptosis in multiple myeloma and overcomes bortezomib resistance Blood (2014) 123, 706-716. PubMed Europe PubMed DOI I

2013

Chen,Y.J., Ma,Y.S., Fang,Y., Wang,Y., Fu,D. and Shen,X.Z. Power and promise of ubiquitin carboxyl-terminal hydrolase 37 as a target of cancer therapy Asian Pac J Cancer Prev (2013) 14, 2173-2179. PubMed Europe PubMed
Ko,Y.M., Chang,C.Y., Chiou,S.J., Hsu,F.J., Huang,J.S., Yang,Y.L., Guh,J.Y. and Chuang,L.Y. Ubiquitin C-terminal hydrolase-L5 is required for high glucose-induced transforming growth factor-beta receptor I expression and hypertrophy in mesangial cells Arch Biochem Biophys (2013) 535, 177-186. PubMed Europe PubMed DOI
Morrow,M.E., Kim,M.I., Ronau,J.A., Sheedlo,M.J., White,R.R., Chaney,J., Paul,L.N., Lill,M.A., Artavanis-Tsakonas,K. and Das,C. Stabilization of an unusual salt bridge in ubiquitin by the extra C-terminal domain of the proteasome-associated deubiquitinase UCH37 as a mechanism of its exo specificity Biochemistry (2013) 52, 3564-3578. PubMed Europe PubMed DOI
Peth,A., Kukushkin,N., Bosse,M. and Goldberg,A.L. Ubiquitinated proteins activate the proteasomal ATPases by binding to Usp14 or Uch37 homologs J Biol Chem (2013) 288, 7781-7790. PubMed Europe PubMed DOI

2012

Iphofer,A., Kummer,A., Nimtz,M., Ritter,A., Arnold,T., Frank,R., van den Heuvel,J., Kessler,B.M., Jansch,L. and Franke,R. Profiling ubiquitin linkage specificities of deubiquitinating enzymes with branched ubiquitin isopeptide probes Chembiochem (2012) 13, 1416-1420. PubMed Europe PubMed DOI P
Yao,T. Ubiquitin carboxyl-terminal hydrolase 37 [ISSN:978-0-12-407743-0] (2012) 3, 2043-2049. DOI
Zhou,Z.R., Zhang,Y.H., Liu,S., Song,A.X. and Hu,H.Y. Length of the active-site crossover loop defines the substrate specificity of ubiquitin C-terminal hydrolases for ubiquitin chains Biochem J (2012) 441, 143-149. PubMed Europe PubMed DOI

2011

D'Arcy,P., Brnjic,S., Olofsson,M.H., Fryknas,M., Lindsten,K., De Cesare,M., Perego,P., Sadeghi,B., Hassan,M., Larsson,R. and Linder,S. Inhibition of proteasome deubiquitinating activity as a new cancer therapy Nat Med (2011) 17, 1636-1640. PubMed Europe PubMed DOI I
Lee,M.J., Lee,B.H., Hanna,J., King,R.W. and Finley,D. Trimming of ubiquitin chains by proteasome-associated deubiquitinating enzymes Mol Cell Proteomics (2011) 10, R110-R110. PubMed Europe PubMed DOI P
Maiti,T.K., Permaul,M., Boudreaux,D.A., Mahanic,C., Mauney,S. and Das,C. Crystal structure of the catalytic domain of UCHL5, a proteasome-associated human deubiquitinating enzyme, reveals an unproductive form of the enzyme FEBS J (2011) 278, 4917-4926. PubMed Europe PubMed DOI S
White,R.R., Miyata,S., Papa,E., Spooner,E., Gounaris,K., Selkirk,M.E. and Artavanis-Tsakonas,K. Characterisation of the Trichinella spiralis deubiquitinating enzyme, TsUCH37, an evolutionarily conserved proteasome interaction partner PLoS Negl Trop Dis (2011) 5, e1340-e1340. PubMed Europe PubMed DOI PMC EPMC

2010

Yeh,H.Y. and Klesius,P.H. Characterization and tissue expression of channel catfish (Ictalurus punctatus Rafinesque, 1818) ubiquitin carboxyl-terminal hydrolase L5 (UCHL5) cDNA Mol Biol Rep (2010) 37, 1229-1234. PubMed Europe PubMed DOI

2009

Nishio,K., Kim,S.W., Kawai,K., Mizushima,T., Yamane,T., Hamazaki,J., Murata,S., Tanaka,K. and Morimoto,Y. Crystal structure of the de-ubiquitinating enzyme UCH37 (human UCH-L5) catalytic domain Biochem Biophys Res Commun (2009) 390, 855-860. PubMed Europe PubMed DOI S

2008

Koulich,E., Li,X. and DeMartino,G.N. Relative structural and functional roles of multiple deubiquitylating proteins associated with mammalian 26S proteasome Mol Biol Cell (2008) 19, 1072-1082. PubMed Europe PubMed DOI PMC EPMC
Yao,T., Song,L., Jin,J., Cai,Y., Takahashi,H., Swanson,S.K., Washburn,M.P., Florens,L., Conaway,R.C., Cohen,R.E. and Conaway,J.W. Distinct modes of regulation of the Uch37 deubiquitinating enzyme in the proteasome and in the Ino80 chromatin-remodeling complex Mol Cell (2008) 31, 909-917. PubMed Europe PubMed DOI PMC EPMC

2006

[YEAR:21-9-2006]Hamazaki,J., Iemura,S., Natsume,T., Yashiroda,H., Tanaka,K. and Murata,S. A novel proteasome interacting protein recruits the deubiquitinating enzyme UCH37 to 26S proteasomes EMBO J (21-9-2006) 25, 4524-4536. PubMed Europe PubMed DOI
Qiu,X.B., Ouyang,S.Y., Li,C.J., Miao,S., Wang,L. and Goldberg,A.L. hRpn13/ADRM1/GP110 is a novel proteasome subunit that binds the deubiquitinating enzyme, UCH37 EMBO J (2006) 25, 5742-5753. PubMed Europe PubMed DOI PMC EPMC
Wicks,S.J., Grocott,T., Haros,K., Maillard,M., ten Dijke,P. and Chantry,A. Reversible ubiquitination regulates the Smad/TGF-beta signalling pathway Biochem Soc Trans (2006) 34, 761-763. PubMed Europe PubMed DOI
[YEAR:13-8-2006]Yao,T., Song,L., Xu,W., DeMartino,G.N., Florens,L., Swanson,S.K., Washburn,M.P., Conaway,R.C., Conaway,J.W. and Cohen,R.E. Proteasome recruitment and activation of the Uch37 deubiquitinating enzyme by Adrm1 Nat Cell Biol (13-8-2006) 8, 994-1002. PubMed Europe PubMed DOI

2005

[YEAR:18-7-2005]Wicks,S.J., Haros,K., Maillard,M., Song,L., Cohen,R.E., Dijke,P.T. and Chantry,A. The deubiquitinating enzyme UCH37 interacts with Smads and regulates TGF-beta signalling Oncogene (18-7-2005) 24, 8080-8084. PubMed Europe PubMed DOI

2000

[YEAR:10-7-2000]Holzl,H., Kapelari,B., Kellermann,J., Seemuller,E., Sumegi,M., Udvardy,A., Medalia,O., Sperling,J., Muller,S.A., Engel,A. and Baumeister,W. The regulatory complex of Drosophila melanogaster 26S proteasomes. Subunit composition and localization of a deubiquitylating enzyme J Cell Biol (10-7-2000) 150, 119-130. PubMed Europe PubMed DOI PMC EPMC