Literature for peptidase C12.004: ubiquitinyl hydrolase-BAP1

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Literature Substrates

(Topics flags: S Structure, T Target, M Mutation, I Inhibitor, K Knockout, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Elsayed,A.M., Kittaneh,M., Cebulla,C.M. and Abdel-Rahman,M.H.
    An overview of BAP1 biological functions and current therapeutics
    Biochim Biophys Acta Rev Cancer1880, 189267-189267. PubMed  Europe PubMed DOI  V
  2. Iwase,R., Maisonet,I.J., Lee,K., Buhrlage,S.J. and Cole,P.A.
    Deubiquitinase processing of a non-natural linkage of ubiquitinated-PTEN
    Bioorg Chem157, 108223-108223. PubMed  Europe PubMed DOI
  3. Shaker,N., Phelps,R., Niedt,G., Sangueza,O., Krishnan,R., Patel,A., Torres-Cabala,C., Aung,P.P., Prieto,V., Dumur,C.I. and Pradhan,D.
    BRCA1-Associated Protein-1 Inactivated Melanoma Arising in a Pre-existing Nevus With ALK Fusion and Low Tumor Mutational Burden
    Am J Dermatopathol PubMed  Europe PubMed DOI
  4. Yu,L., Zheng,X., Wu,Y. and Ge,K.
    USP14-Dependent IGF1R Aggravates High Glucose-Induced Diabetic Retinopathy by Upregulating BAP1
    Appl Biochem Biotechnol PubMed  Europe PubMed DOI
  5. 2024
  6. Cai,W., Wu,S., Lin,Z., Ming,X., Yang,X., Yang,M. and Chen,X.
    Hypoxia-induced BAP1 enhances erastin-induced ferroptosis in nasopharyngeal carcinoma by stabilizing H2A
    Cancer Cell Int24, 307-307. PubMed  Europe PubMed DOI  K
  7. Chang,H., Li,M., Zhang,L., Li,M., Ong,S.H., Zhang,Z., Zheng,J., Xu,X., Zhang,Y., Wang,J., Liu,X., Li,K., Luo,Y., Wang,H., Miao,Z., Chen,X., Zha,J. and Yu,Y.
    Loss of histone deubiquitinase Bap1 triggers anti-tumor immunity
    Cell Oncol (Dordr) PubMed  Europe PubMed DOI
  8. Gonzalez-Fernandez,M., Perry,C., Gerhards,N.M., Francica,P. and Rottenberg,S.
    Docetaxel response in BRCA1,p53-deficient mammary tumor cells is affected by Huntingtin and BAP1
    Proc Natl Acad Sci U S A121, e2402849121-e2402849121. PubMed  Europe PubMed DOI
  9. Greco,F., D'Andrea,V., Buoso,A., Cea,L., Bernetti,C., Beomonte Zobel,B. and Mallio,C.A.
    Advancements in Radiogenomics for Clear Cell Renal Cell Carcinoma: Understanding the Impact of BAP1 Mutation
    J Clin Med13, PubMed  Europe PubMed DOI  V
  10. Kim,S., Lee,E.W., Oh,D.B. and Seo,J.
    BAP1 controls mesenchymal stem cell migration by inhibiting the ERK signaling pathway
    BMB Rep57, 250-255. PubMed  Europe PubMed  K
  11. Liu,X., Cui,L., Tao,Y., Xia,S., Hou,J., Cao,X. and Xu,S.
    The deubiquitinase BAP1 and E3 ligase UBE3C sequentially target IRF3 to activate and resolve the antiviral innate immune response
    Cell Rep43, 114608-114608. PubMed  Europe PubMed DOI
  12. Repo,P.E., Backlund,M.P., Kivela,T.T. and Turunen,J.A.
    Functional assay for assessment of pathogenicity of BAP1 variants
    Hum Mol Genet33, 426-434. PubMed  Europe PubMed DOI
  13. Shenouda,M., Shaikh,A., Deutsch,I., Mitchell,O., Kindler,H.L. and Armato,S.G., III
    Radiomics for differentiation of somatic BAP1 mutation on CT scans of patients with pleural mesothelioma
    J Med Imaging (Bellingham)11, 064501-064501. PubMed  Europe PubMed DOI
  14. Wang,J., Wang,M., Wu,S., Zhu,Y., Fan,K., Chen,Y., Xiao,Z., Chen,J., Tu,K., Huang,D., Zhang,Y. and Xu,Q.
    Tumor suppressor BAP1 suppresses disulfidptosis through the regulation of SLC7A11 and NADPH levels
    Oncogenesis13, 31-31. PubMed  Europe PubMed DOI
  15. Xie,Z., Lin,H., Huang,Y., Wang,X., Lin,H., Xu,M., Wu,J., Wu,Y., Shen,H., Zhang,Q., Chen,J., Deng,Y., Xu,Z., Chen,Z., Lin,Y., Han,Y., Lin,L., Yan,L., Li,Q., Lin,X. and Chi,P.
    BAP1-mediated MAFF deubiquitylation regulates tumor growth and is associated with adverse outcomes in colorectal cancer
    Eur J Cancer210, 114278-114278. PubMed  Europe PubMed DOI  K
  16. Xu,Z., Zhang,N. and Shi,L.
    Potential roles of UCH family deubiquitinases in tumorigenesis and chemical inhibitors developed against them
    Am J Cancer Res14, 2666-2694. PubMed  Europe PubMed DOI  V
  17. Yuan,W., Zhang,Q., Zhao,Y., Xia,W., Yin,S., Liang,X., Chen,T., Li,G., Liu,Y., Liu,Z. and Huang,J.
    BAP1 regulates HSF1 activity and cancer immunity in pancreatic cancer
    J Exp Clin Cancer Res43, 275-275. PubMed  Europe PubMed DOI
  18. Zhang,Y., Xie,G., Lee,J.E., Zandian,M., Sudarshan,D., Estavoyer,B., Benz,C., Viita,T., Asgaritarghi,G., Lachance,C., Messmer,C., Simonetti,L., Sinha,V.K., Lambert,J.P., Chen,Y.W., Wang,S.P., Ivarsson,Y., Affar,E.B., Cote,J., Ge,K. and Kutateladze,T.G.
    ASXLs binding to the PHD2/3 fingers of MLL4 provides a mechanism for the recruitment of BAP1 to active enhancers
    Nat Commun15, 4883-4883. PubMed  Europe PubMed DOI
  19. 2023
  20. Ge,W., Yu,C., Li,J., Yu,Z., Li,X., Zhang,Y., Liu,C.P., Li,Y., Tian,C., Zhang,X., Li,G., Zhu,B. and Xu,R.M.
    Basis of the H2AK119 specificity of the Polycomb repressive deubiquitinase
    Nature616, 176-182. PubMed  Europe PubMed DOI
  21. Gillies,B., Krema,H., Chao,A., Lando,L., Farncombe,K.M., Butler,M., Altomare,F. and Kim,R.H.
    Oncologist-led germline genetic testing for uveal melanoma
    Ophthalmic Genet44, 253-261. PubMed  Europe PubMed DOI  V
  22. Kwon,J., Lee,D. and Lee,S.A.
    BAP1 as a guardian of genome stability: implications in human cancer
    Exp Mol Med55, 745-754. PubMed  Europe PubMed DOI  V
  23. Lu,W.T., Li,M.R., Yang,Y.B., Sun,Y.Y. and Dong,C.M.
    Research Progress of BAP1 in Structure, Function, and Cancer
    Protein Pept Lett30, 552-561. PubMed  Europe PubMed DOI
  24. Luo,S., Gong,J., Zhao,S., Li,M. and Li,R.
    Deubiquitinase BAP1 regulates stability of BRCA1 protein and inactivates the NF-kappaB signaling to protect mice from sepsis-induced acute kidney injury
    Chem Biol Interact382, 110621-110621. PubMed  Europe PubMed DOI
  25. Martinez-Fernandez,C., Jha,S., Aliagas,E., Holmberg,C.I., Nadal,E. and Ceron,J.
    BAP1 Malignant Pleural Mesothelioma Mutations in Caenorhabditis elegans Reveal Synthetic Lethality between ubh-4/BAP1 and the Proteasome Subunit rpn-9/PSMD13
    Cells12, PubMed  Europe PubMed DOI
  26. Rohatgi,N., Zou,W., Li,Y., Cho,K., Collins,P.L., Tycksen,E., Pandey,G., DeSelm,C.J., Patti,G.J., Dey,A. and Teitelbaum,S.L.
    BAP1 promotes osteoclast function by metabolic reprogramming
    Nat Commun14, 5923-5923. PubMed  Europe PubMed DOI
  27. Shi,W., Liu,X., Zhang,G., Ye,L., Zhou,R., Li,Y. and Yu,L.
    [RITA selectively inhibits proliferation of BAP1-deficient cutaneous melanoma cells in vitro]
    Nan Fang Yi Ke Da Xue Xue Bao43, 710-717. PubMed  Europe PubMed DOI
  28. Thomas,J.F., Valencia-Sanchez,M.I., Tamburri,S., Gloor,S.L., Rustichelli,S., Godinez-Lopez,V., De Ioannes,P., Lee,R., Abini-Agbomson,S., Gretarsson,K., Burg,J.M., Hickman,A.R., Sun,L., Gopinath,S., Taylor,H.F., Sun,Z.W., Ezell,R.J., Vaidya,A., Meiners,M.J., Cheek,M.A., Rice,W.J., Svetlov,V., Nudler,E., Lu,C., Keogh,M.C., Pasini,D. and Armache,K.J.
    Structural basis of histone H2A lysine 119 deubiquitination by Polycomb repressive deubiquitinase BAP1/ASXL1
    Sci Adv9, eadg9832-eadg9832. PubMed  Europe PubMed DOI
  29. Zhang,C. and Wu,S.
    BAP1 mutations inhibit the NF-kappaB signaling pathway to induce an immunosuppressive microenvironment in uveal melanoma
    Mol Med29, 126-126. PubMed  Europe PubMed DOI
  30. Zhang,X., Cong,X., Jin,X., Liu,Y., Zhang,T., Fan,X., Shi,X., Zhang,X., Wang,X., Yang,Y.G. and Dai,X.
    Deficiency of BAP1 inhibits neuroblastoma tumorigenesis through destabilization of MYCN
    Cell Death Dis14, 504-504. PubMed  Europe PubMed DOI  K
  31. 2022
  32. Baqai,U., Purwin,T.J., Bechtel,N., Chua,V., Han,A., Hartsough,E.J., Kuznetsoff,J.N., Harbour,J.W. and Aplin,A.E.
    Multi-omics profiling shows BAP1 loss is associated with upregulated cell adhesion molecules in uveal melanoma
    Mol Cancer Res20, 1260-1271. PubMed  Europe PubMed DOI  K
  33. Blatnik,A., Ribnikar,D., Setrajcic Dragos,V., Novakovic,S., Stegel,V., Grcar Kuzmanov,B., Boc,N., Peric,B., Skerl,P., Klancar,G. and Krajc,M.
    BAP1-defficient breast cancer in a patient with BAP1 cancer syndrome
    Breast Cancer29, 921-927. PubMed  Europe PubMed DOI
  34. Caporali,S., Butera,A. and Amelio,I.
    BAP1 in cancer: epigenetic stability and genome integrity
    Discov Oncol13, 117-117. PubMed  Europe PubMed DOI
  35. Djulbegovic,M.B., Taylor,D.J., Uversky,V.N., Galor,A., Shields,C.L. and Karp,C.L.
    Intrinsic Disorder in BAP1 and Its Association with Uveal Melanoma
    Genes (Basel)13, PubMed  Europe PubMed DOI
  36. Estavoyer,B., Messmer,C., Echbicheb,M., Rudd,C.E., Milot,E. and Affar,E.B.
    Mechanisms orchestrating the enzymatic activity and cellular functions of deubiquitinases
    J Biol Chem298, 102198-102198. PubMed  Europe PubMed DOI
  37. Han,A., Chua,V., Baqai,U., Purwin,T.J., Bechtel,N., Hunter,E., Tiago,M., Seifert,E., Speicher,D.W., Schug,Z.T., Harbour,J.W. and Aplin,A.E.
    Pyruvate dehydrogenase inactivation causes glycolytic phenotype in BAP1 mutant uveal melanoma
    Oncogene41, 1129-1139. PubMed  Europe PubMed DOI
  38. Husain,S., Mohamed,R., Abd Halim,K.B. and Mohd Mutalip,S.S.
    Homology modeling of human BAP1 and analysis of its binding properties through molecular docking and molecular dynamics simulation
    J Biomol Struct Dyn1-16. PubMed  Europe PubMed DOI
  39. Jeong,J., Jung,I., Kim,J.H., Jeon,S., Hyeon,D.Y., Min,H., Kang,B., Nah,J., Hwang,D., Um,S.J., Ko,M. and Seong,R.H.
    BAP1 shapes the bone marrow niche for lymphopoiesis by fine-tuning epigenetic profiles in endosteal mesenchymal stromal cells
    Cell Death Differ29, 2151-2162. PubMed  Europe PubMed DOI
  40. Kang,J.S., Nam,L.B., Yoo,O.K., Lee,K., Suh,Y.A., Kim,D., Kim,W.K., Lim,C.Y., Lee,H. and Keum,Y.S.
    BAP1 Downregulates NRF2 Target Genes and Exerts Anti-Tumorigenic Effects by Deubiquitinating KEAP1 in Lung Adenocarcinoma
    Antioxidants (Basel)11, PubMed  Europe PubMed DOI
  41. Kong,Y., Ren,W., Fang,H., Shah,N.A., Shi,Y., You,D., Zhou,C., Jiang,D., Yang,C., Liang,H., Liu,W., Wang,L., Gan,W., Wan,X., Li,F., Li,Z., Chen,C. and Xie,N.
    Histone Deacetylase Inhibitors (HDACi) Promote KLF5 Ubiquitination and Degradation in Basal-like Breast Cancer
    Int J Biol Sci18, 2104-2115. PubMed  Europe PubMed DOI
  42. Langbein,L.E., Sementino,E., Zhong,Z., Jiang,W., Li,L., Testa,J.R. and Yang,H.
    Data supporting the roles of BAP1, STING, and IFN-beta in ISGF3 activation in ccRCC
    Data Brief45, 108743-108743. PubMed  Europe PubMed DOI  K
  43. Langbein,L.E., El Hajjar,R., He,S., Sementino,E., Zhong,Z., Jiang,W., Leiby,B.E., Li,L., Uzzo,R.G., Testa,J.R. and Yang,H.
    BAP1 maintains HIF-dependent interferon beta induction to suppress tumor growth in clear cell renal cell carcinoma
    Cancer Lett547, 215885-215885. PubMed  Europe PubMed DOI
  44. Lee,S.A., Lee,D., Kang,M., Kim,S., Kwon,S.J., Lee,H.S., Seo,H.R., Kaushal,P., Lee,N.S., Kim,H., Lee,C. and Kwon,J.
    BAP1 promotes the repair of UV-induced DNA damage via PARP1-mediated recruitment to damage sites and control of activity and stability
    Cell Death Differ29, 2381-2398. PubMed  Europe PubMed DOI
  45. Liu,R.J., Xu,Z.P., Li,S.Y., Yu,J.J., Feng,N.H., Xu,B. and Chen,M.
    BAP1-Related ceRNA (NEAT1/miR-10a-5p/SERPINE1) Promotes Proliferation and Migration of Kidney Cancer Cells
    Front Oncol12, 852515-852515. PubMed  Europe PubMed DOI  K
  46. Pandithan,D., Klebe,S., McKavanagh,G., Rawlings,L., Yu,S., Nicholl,J. and Poplawski,N.
    BAP1 Tumour Predisposition Syndrome Due to Whole BAP1 Gene Deletion
    Case Rep Genet2022, 5503505-5503505. PubMed  Europe PubMed DOI
  47. Puri,S., Chen,S.N., Chiu,Y.H., Draczkowski,P., Ko,K.T., Yang,T.J., Wang,Y.S., Uchiyama,S. and Hsu,S.D.
    Impacts of Cancer-associated Mutations on the Structure-Activity Relationship of BAP1
    J Mol Biol434, 167553-167553. PubMed  Europe PubMed DOI
  48. Seo,S.U., Woo,S.M., Lee,S.G., Kim,M.Y., Lee,H.S., Choi,Y.H., Kim,S.H., Chang,Y.C., Min,K.J. and Kwon,T.K.
    BAP1 phosphorylation-mediated Sp1 stabilization plays a critical role in cathepsin K inhibition-induced C-terminal p53-dependent Bax upregulation
    Redox Biol53, 102336-102336. PubMed  Europe PubMed DOI  K
  49. Takagi-Kimura,M., Tada,A., Kijima,T., Kubo,S., Ohmuraya,M. and Yoshikawa,Y.
    BAP1 depletion in human B-lymphoblast cells affects the production of innate immune cytokines and chemokines
    Genes Cells27, 731-740. PubMed  Europe PubMed DOI
  50. Tsuboyama,N., Szczepanski,A.P., Zhao,Z. and Wang,L.
    MBD5 and MBD6 stabilize the BAP1 complex and promote BAP1-dependent cancer
    Genome Biol23, 206-206. PubMed  Europe PubMed DOI
  51. Tsuboyama,N., Wang,R., Szczepanski,A.P., Chen,H., Zhao,Z., Shi,L. and Wang,L.
    Therapeutic targeting of BAP1/ASXL3 sub-complex in ASCL1-dependent small cell lung cancer
    Oncogene41, 2152-2162. PubMed  Europe PubMed DOI  I
  52. Wang,T., Zhu,T., Zhang,Y., Bai,J., Xue,Y., Xu,G., Lu,L. and Peng,Q.
    Pan-cancer analysis of the prognostic and immunological role of BRCA1-associated protein 1 gene (BAP1): Friend or foe?
    Gene840, 146765-146765. PubMed  Europe PubMed DOI
  53. Yang,T.J., Li,T.N., Huang,R.S., Pan,M.Y., Lin,S.Y., Lin,S., Wu,K.P., Wang,L.H. and Hsu,S.D.
    Tumor suppressor BAP1 nuclear import is governed by transportin-1
    J Cell Biol221, PubMed  Europe PubMed DOI
  54. Zhao,J., Wan,X.N., Zhu,J.P., Liu,Q.C. and Gan,L.
    LncRNA NEAT1 promoted MPP+induced ferroptosis via regulating miR1505p/BAP1 pathway in SKNSH cells
    Acta Neurobiol Exp (Wars)82, 226-236. PubMed  Europe PubMed DOI  K
  55. Zhao,Z., Rendleman,E.J., Szczepanski,A.P., Morgan,M.A., Wang,L. and Shilatifard,A.
    CARM1-mediated methylation of ASXL2 impairs tumor-suppressive function of MLL3/COMPASS
    Sci Adv8, eadd3339-eadd3339. PubMed  Europe PubMed DOI
  56. 2021
  57. Baas,R., der Wal,J.v., Bleijerveld,O.B., van Attikum,H. and Sixma,T.K.
    Proteomic analysis identifies novel binding partners of BAP1
    PLoS ONE16, e0257688-e0257688. PubMed  Europe PubMed DOI
  58. Cao,L., Li,R. and Wu,X.
    The Functions and Mechanisms of PR-DUB in Malignancy
    Front Mol Biosci8, 657150-657150. PubMed  Europe PubMed DOI  V
  59. Chen,X., Huang,A., Wang,Y., Chen,F., Hu,B., Zhang,X., Sun,Y., Wang,J., Cheng,J., Wang,P., Ji,Y., Qiu,S., Fan,J., Zhou,J. and Yang,X.
    BRCA1-associated protein 1 serves as a tumor suppressor in hepatocellular carcinoma by deubiquitinating and stabilizing PTEN
    Am J Cancer Res11, 2044-2061. PubMed  Europe PubMed
  60. Conway,E., Rossi,F., Fernandez-Perez,D., Ponzo,E., Ferrari,K.J., Zanotti,M., Manganaro,D., Rodighiero,S., Tamburri,S. and Pasini,D.
    BAP1 enhances Polycomb repression by counteracting widespread H2AK119ub1 deposition and chromatin condensation
    Mol Cell PubMed  Europe PubMed DOI
  61. Han,A., Purwin,T.J. and Aplin,A.E.
    Roles of the BAP1 tumor suppressor in cell metabolism
    Cancer Res PubMed  Europe PubMed DOI  V
  62. Ishii,Y., Kolluri,K.K., Pennycuick,A., Zhang,X., Nigro,E., Alrifai,D., Borg,E., Falzon,M., Shah,K., Kumar,N. and Janes,S.M.
    BAP1 and YY1 regulate expression of death receptors in malignant pleural mesothelioma
    J Biol Chem297, 101223-101223. PubMed  Europe PubMed DOI  K
  63. Jia,X., Chen,H., Ren,Y., Dejizhuoga, Gesangyuzhen, Gao,N., Feng,H., Huang,W., Liao,Y. and Yu,H.
    BAP1 antagonizes WWP1-mediated transcription factor KLF5 ubiquitination and inhibits autophagy to promote melanoma progression
    Exp Cell Res112506-112506. PubMed  Europe PubMed DOI
  64. Lin,Y.H., Liang,Y., Wang,H., Tung,L.T., Forster,M., Subramani,P.G., Di Noia,J.M., Clare,S., Langlais,D. and Nijnik,A.
    Regulation of B Lymphocyte Development by Histone H2A Deubiquitinase BAP1
    Front Immunol12, 626418-626418. PubMed  Europe PubMed DOI
  65. Novelli,F., Bononi,A., Wang,Q., Bai,F., Patergnani,S., Kricek,F., Haglund,E., Suarez,J.S., Tanji,M., Xu,R., Takanishi,Y., Minaai,M., Pastorino,S., Morris,P., Sakamoto,G., Pass,H.I., Barbour,H., Gaudino,G., Giorgi,C., Pinton,P., Onuchic,J.N., Yang,H. and Carbone,M.
    BAP1 forms a trimer with HMGB1 and HDAC1 that modulates gene x environment interaction with asbestos
    Proc Natl Acad Sci U S A118, PubMed  Europe PubMed DOI
  66. Peng,H., Cassel,J., McCracken,D.S., Prokop,J.W., Sementino,E., Cheung,M., Collop,P.R., Polo,A., Joshi,S., Mandell,J.P., Ayyanathan,K., Hinds,D., Malkowicz,S.B., Harbour,J.W., Bowcock,A.M., Salvino,J., Kennedy,E.J., Testa,J.R. and Rauscher,F.J., III
    Kinetic Characterization of ASXL1/2-Mediated Allosteric Regulation of the BAP1 Deubiquitinase
    Mol Cancer Res PubMed  Europe PubMed DOI
  67. Seo,H.R., Jeong,D., Lee,S., Lee,H.S., Lee,S.A., Kang,S.W. and Kwon,J.
    CHIP and BAP1 Act in Concert to Regulate INO80 Ubiquitination and Stability for DNA Replication
    Mol Cells44, 101-115. PubMed  Europe PubMed DOI
  68. Szczepanski,A.P. and Wang,L.
    Emerging multifaceted roles of BAP1 complexes in biological processes
    Cell Death Discov7, 20-20. PubMed  Europe PubMed DOI  V
  69. Wang,F., Luo,M., Qu,H. and Cheng,Y.
    BAP1 promotes viability and migration of ECA109 cells through KLF5/CyclinD1/FGF-BP1
    FEBS Open Bio PubMed  Europe PubMed DOI  K
  70. Wang,L., Birch,N.W., Zhao,Z., Nestler,C.M., Kazmer,A., Shilati,A., Blake,A., Ozark,P.A., Rendleman,E.J., Zha,D., Ryan,C.A., Morgan,M.A.J. and Shilatifard,A.
    Epigenetic targeted therapy of stabilized BAP1 in ASXL1 gain-of-function mutated leukemia
    Nat Cancer2, 515-526. PubMed  Europe PubMed DOI
  71. Xia,Y.K., Zeng,Y.R., Zhang,M.L., Liu,P., Liu,F., Zhang,H., He,C.X., Sun,Y.P., Zhang,J.Y., Zhang,C., Song,L., Ding,C., Tang,Y.J., Yang,Z., Yang,C., Wang,P., Guan,K.L., Xiong,Y. and Ye,D.
    Tumor-derived neomorphic mutations in ASXL1 impairs the BAP1-ASXL1-FOXK1/K2 transcription network
    Protein Cell12, 557-577. PubMed  Europe PubMed DOI
  72. Zhao,C.X., Zeng,C.M., Wang,K., He,Q.J., Yang,B., Zhou,F.F. and Zhu,H.
    Ubiquitin-proteasome system-targeted therapy for uveal melanoma: what is the evidence?
    Acta Pharmacol Sin42, 179-188. PubMed  Europe PubMed DOI
  73. 2020
  74. Carbone,M., Harbour,J.W., Brugarolas,J., Bononi,A., Pagano,I., Dey,A., Krausz,T., Pass,H.I., Yang,H. and Gaudino,G.
    Biological Mechanisms and Clinical Significance of BAP1 Mutations in Human Cancer
    Cancer Discov10, 1103-1120. PubMed  Europe PubMed DOI
  75. Carrera,W.M., Denny,M.R. and Seider,M.I.
    Crystalline Lens Resorption Caused by Ciliary Body Melanoma
    Case Rep Oncol13, 497-500. PubMed  Europe PubMed DOI
  76. Chevrier,M., Monaco,S.E., Jerome,J.A., Galateau-Salle,F., Churg,A. and Dacic,S.
    Testing for BAP1 loss and CDKN2A/p16 homozygous deletion improves the accurate diagnosis of mesothelial proliferations in effusion cytology
    Cancer Cytopathol PubMed  Europe PubMed DOI
  77. Dacic,S., Roy,S., Lyons,M.A., von der Thusen,J.H., Galateau-Salle,F. and Churg,A.
    Whole exome sequencing reveals BAP1 somatic abnormalities in mesothelioma in situ
    Lung Cancer149, 1-4. PubMed  Europe PubMed DOI
  78. Deng,R., Guo,Y., Li,L., He,J., Qiang,Z., Zhang,H., Chen,R., Wang,Y., Zhao,X. and Yu,J.
    BAP1 suppresses prostate cancer progression by deubiquitinating and stabilizing PTEN
    Mol Oncol PubMed  Europe PubMed DOI  K
  79. Jadhav,S., Kumari,N., Ng,L., Tan,P.F., Yeo-Teh,N.S.L., Goh,Y., Fam,W.N., Tng,J.Q., Tian,J.S., Koh,B.T.H., Chun,C.M., Wang,W., Chng,W.J., Fullwood,M.J., Guccione,E., Karnani,N., Tenen,D.G. and Jha,S.
    circASXL1-1 regulates BAP1 deubiquitinase activity in leukemia
    Haematologica105, e343-e348. PubMed  Europe PubMed DOI
  80. Kinoshita,Y., Hamasaki,M., Matsumoto,S., Yoshimura,M., Sato,A., Tsujimura,T., Kamei,T., Kawahara,K. and Nabeshima,K.
    Genomic-based ancillary assays offer improved diagnostic yield of effusion cytology with potential challenges in malignant pleural mesothelioma
    Pathol Int PubMed  Europe PubMed DOI
  81. Kobrinski,D.A., Yang,H. and Kittaneh,M.
    BAP1: role in carcinogenesis and clinical implications
    Transl Lung Cancer Res9, S60-S60. PubMed  Europe PubMed DOI
  82. Kolovos,P., Nishimura,K., Sankar,A., Sidoli,S., Cloos,P.A., Helin,K. and Christensen,J.
    PR-DUB maintains the expression of critical genes through FOXK1/2- and ASXL1/2/3-dependent recruitment to chromatin and H2AK119ub1 deubiquitination
    Genome Res PubMed  Europe PubMed DOI
  83. Louw,A., Creaney,J., Thomas,A., Van Vliet,C., Harvey,N.T., Wood,B.A. and Mesbah Ardakani,N.
    Histologically Diverse BAP1-Deficient Melanocytic Tumors in a Patient With BAP1 Tumor Predisposition Syndrome
    Am J Dermatopathol PubMed  Europe PubMed DOI
  84. Luo,X., Xu,Y., Li,Y., Zhang,G., Huang,S., Liu,X., Ren,Z., Liu,S. and Yu,L.
    BAP1 deletion abrogates growth and metastasis of murine cutaneous melanoma
    Melanoma ResPublish Ahead of Print, PubMed  Europe PubMed DOI
  85. Ozdemir,H.G., Kokten,S.C. and Barisik,N.O.
    Can BAP1 expression loss in mesothelial cells be an indicator of malignancy?
    J Pathol Transl Med54, 497-503. PubMed  Europe PubMed DOI
  86. Perkail,S., Andricovich,J., Kai,Y. and Tzatsos,A.
    BAP1 is a haploinsufficient tumor suppressor linking chronic pancreatitis to pancreatic cancer in mice
    Nat Commun11, 3018-3018. PubMed  Europe PubMed DOI
  87. Szczepanski,A.P., Zhao,Z., Sosnowski,T., Goo,Y.A., Bartom,E.T. and Wang,L.
    ASXL3 bridges BRD4 to BAP1 complex and governs enhancer activity in small cell lung cancer
    Genome Med12, 63-63. PubMed  Europe PubMed DOI
  88. Tan,G., Xuan,Z., Li,Z., Huang,S., Chen,G., Wu,Y., Chen,X., Liang,Z. and Wu,A.
    The critical role of BAP1 mutation in the prognosis and treatment selection of kidney renal clear cell carcinoma
    Transl Androl Urol9, 1725-1734. PubMed  Europe PubMed DOI  V
  89. Xiong,Z., Xia,P., Zhu,X., Geng,J., Wang,S., Ye,B., Qin,X., Qu,Y., He,L., Fan,D., Du,Y., Tian,Y. and Fan,Z.
    Glutamylation of deubiquitinase BAP1 controls self-renewal of hematopoietic stem cells and hematopoiesis
    J Exp Med217, e20190974-e20190974. PubMed  Europe PubMed DOI
  90. Yu,M.D., Masoomian,B., Shields,J.A. and Shields,C.L.
    BAP1 Germline mutation associated with bilateral primary uveal melanoma
    Ocul Oncol Pathol6, 10-14. PubMed  Europe PubMed DOI  M
  91. 2019
  92. Artegiani,B., van Voorthuijsen,L., Lindeboom,R.G.H., Seinstra,D., Heo,I., Tapia,P., Lopez-Iglesias,C., Postrach,D., Dayton,T., Oka,R., Hu,H., van Boxtel,R., van Es,J.H., Offerhaus,J., Peters,P.J., van Rheenen,J., Vermeulen,M. and Clevers,H.
    Probing the tumor suppressor function of BAP1 in CRISPR-engineered human liver organoids
    Cell Stem Cell24, 927-943. PubMed  Europe PubMed DOI  K
  93. Boru,G., Grosel,T.W., Pilarski,R., Stautberg,M., Massengill,J.B., Jeter,J., Singh,A., Marino,M.J., McElroy,J.P., Davidorf,F.H., Cebulla,C.M. and Abdel-Rahman,M.H.
    Germline large deletion of BAP1 and decreased expression in non-tumor choroid in uveal melanoma patients with high risk for inherited cancer
    Genes Chromosomes Cancer58, 650-656. PubMed  Europe PubMed DOI  M
  94. Campagne,A., Lee,M.K., Zielinski,D., Michaud,A., Le Corre,S., Dingli,F., Chen,H., Shahidian,L.Z., Vassilev,I., Servant,N., Loew,D., Pasmant,E., Postel-Vinay,S., Wassef,M. and Margueron,R.
    BAP1 complex promotes transcription by opposing PRC1-mediated H2A ubiquitylation
    Nat Commun10, 348-348. PubMed  Europe PubMed DOI
  95. De,I., Chittock,E.C., Grotsch,H., Miller,T.C.R., McCarthy,A.A. and Muller,C.W.
    Structural basis for the activation of the deubiquitinase Calypso by the Polycomb protein ASX
    Structure27, 528-536. PubMed  Europe PubMed DOI  S
  96. Sharma,A., Biswas,A., Liu,H., Sen,S., Paruchuri,A., Katsonis,P., Lichtarge,O., Chand Dakal,T., Maulik,U., Gromiha,M.M., Bandyopadhyay,S., Ludwig,M., Holz,F.G., Loeffler,K.U. and Herwig-Carl,M.C.
    Mutational landscape of the BAP1 locus reveals an intrinsic control to regulate the miRNA network and the binding of protein complexes in uveal melanoma
    Cancers (Basel)11, PubMed  Europe PubMed DOI  M
  97. 2018
  98. Arenzana,T.L., Lianoglou,S., Seki,A., Eidenschenk,C., Cheung,T., Seshasayee,D., Hagenbeek,T., Sambandam,A., Noubade,R., Peng,I., Lesch,J., Devoss,J., Wu,X., Lee,W.P., Caplazi,P., Webster,J., Liu,J., Pham,V.C., Arnott,D., Lill,J.R., Modrusan,Z., Dey,A. and Rutz,S.
    Tumor suppressor BAP1 is essential for thymic development and proliferative responses of T lymphocytes
    Sci Immunol3, PubMed  Europe PubMed DOI  M
  99. Daou,S., Barbour,H., Ahmed,O., Masclef,L., Baril,C., Sen Nkwe,N., Tchelougou,D., Uriarte,M., Bonneil,E., Ceccarelli,D., Mashtalir,N., Tanji,M., Masson,J.Y., Thibault,P., Sicheri,F., Yang,H., Carbone,M., Therrien,M. and Affar,E.B.
    Monoubiquitination of ASXLs controls the deubiquitinase activity of the tumor suppressor BAP1
    Nat Commun9, 4385-4385. PubMed  Europe PubMed DOI
  100. Foglizzo,M., Middleton,A.J., Burgess,A.E., Crowther,J.M., Dobson,R.C.J., Murphy,J.M., Day,C.L. and Mace,P.D.
    A bidentate polycomb repressive-deubiquitinase complex is required for efficient activity on nucleosomes
    Nat Commun9, 3932-3932. PubMed  Europe PubMed DOI  S
  101. Guo,Y., Yang,H., Chen,S., Zhang,P., Li,R., Nimer,S.D., Harbour,J.W., Xu,M. and Yang,F.C.
    Reduced BAP1 activity prevents ASXL1 truncation-driven myeloid malignancy in vivo
    Leukemia32, 1834-1837. PubMed  Europe PubMed DOI
  102. Peng,H., Prokop,J., Karar,J., Park,K., Cao,L., Harbour,J.W., Bowcock,A.M., Malkowicz,S.B., Cheung,M., Testa,J.R. and Rauscher FJ 3rd
    Familial and somatic BAP1 mutations inactivate ASXL1/2-mediated allosteric regulation of BAP1 deubiquitinase by targeting multiple independent domains
    Cancer Res78, 1200-1213. PubMed  Europe PubMed DOI  M
  103. 2017
  104. Dai,F., Lee,H., Zhang,Y., Zhuang,L., Yao,H., Xi,Y., Xiao,Z.D., You,M.J., Li,W., Su,X. and Gan,B.
    BAP1 inhibits the ER stress gene regulatory network and modulates metabolic stress response
    Proc Natl Acad Sci U S A114, 3192-3197. PubMed  Europe PubMed DOI  K
  105. Hanpude,P., Bhattacharya,S., Singh,A.K. and Maiti,T.K.
    Ubiquitin recognition of BAP1: understanding its enzymatic function
    Biosci Rep37, BSR20171099-BSR20171099. PubMed  Europe PubMed DOI
  106. Shankar,G.M., Abedalthagafi,M., Vaubel,R.A., Merrill,P.H., Nayyar,N., Gill,C.M., Brewster,R., Bi,W.L., Agarwalla,P.K., Thorner,A.R., Reardon,D.A., Al-Mefty,O., Wen,P.Y., Alexander,B.M., van Hummelen,P., Batchelor,T.T., Ligon,K.L., Ligon,A.H., Meyerson,M., Dunn,I.F., Beroukhim,R., Louis,D.N., Perry,A., Carter,S.L., Giannini,C., Curry,W.T., Jr., Cahill,D.P., Barker,F.G.2., Brastianos,P.K. and Santagata,S.
    Germline and somatic BAP1 mutations in high-grade rhabdoid meningiomas
    Neuro Oncol19, 535-545. PubMed  Europe PubMed DOI  M
  107. Wang,X.Y., Wang,Z., Huang,J.B., Ren,X.D., Ye,D., Zhu,W.W. and Qin,L.X.
    Tissue-specific significance of BAP1 gene mutation in prognostic prediction and molecular taxonomy among different types of cancer
    Tumour Biol39, 1010428317699111-1010428317699111. PubMed  Europe PubMed DOI  M
  108. 2016
  109. Abdel-Rahman,M.H., Rai,K., Pilarski,R., Davidorf,F.H. and Cebulla,C.M.
    Germline BAP1 mutations misreported as somatic based on tumor-only testing
    Fam Cancer15, 327-330. PubMed  Europe PubMed DOI  M
  110. Andrici,J., Goeppert,B., Sioson,L., Clarkson,A., Renner,M., Stenzinger,A., Tayao,M., Watson,N., Farzin,M., Toon,C.W., Smith,R.C., Mittal,A., Samra,J.S., Hugh,T.J., Chou,A., Lawlor,R.T., Weichert,W., Schirmacher,P., Sperandio,N., Ruzzenente,A., Scarpa,A. and Gill,A.J.
    Loss of BAP1 expression occurs frequently in intrahepatic cholangiocarcinoma
    Medicine (Baltimore)95, e2491-e2491. PubMed  Europe PubMed DOI  M
  111. Decatur,C.L., Ong,E., Garg,N., Anbunathan,H., Bowcock,A.M., Field,M.G. and Harbour,J.W.
    Driver mutations in uveal melanoma: associations with gene expression profile and patient outcomes
    JAMA Ophthalmol134, 728-733. PubMed  Europe PubMed DOI  M
  112. Kadariya,Y., Cheung,M., Xu,J., Pei,J., Sementino,E., Menges,C.W., Cai,K.Q., Rauscher,F.J., Klein-Szanto,A.J. and Testa,J.R.
    BAP1 is a bona fide tumor suppressor: genetic evidence from mouse models carrying heterozygous germline Bap1 mutations
    Cancer Res76, 2836-2844. PubMed  Europe PubMed DOI  M
  113. Kyrieleis,O.J., McIntosh,P.B., Webb,S.R., Calder,L.J., Lloyd,J., Patel,N.A., Martin,S.R., Robinson,C.V., Rosenthal,P.B. and Smerdon,S.J.
    Three-dimensional architecture of the human BRCA1-A histone deubiquitinase core complex
    Cell Rep17, 3099-3106. PubMed  Europe PubMed DOI
  114. Lai,J., Zhou,Z., Tang,X.J., Gao,Z.B., Zhou,J. and Chen,S.Q.
    A tumor-specific neo-antigen caused by a frameshift mutation in BAP1 is a potential personalized biomarker in malignant peritoneal mesothelioma
    Int J Mol Sci17, PubMed  Europe PubMed DOI  M
  115. McDonnell,K.J., Gallanis,G.T., Heller,K.A., Melas,M., Idos,G.E., Culver,J.O., Martin,S.E., Peng,D.H. and Gruber,S.B.
    A novel BAP1 mutation is associated with melanocytic neoplasms and thyroid cancer
    Cancer Genet209, 75-81. PubMed  Europe PubMed DOI  M
  116. O'Shea,S.J., Mitra,A., Graham,J.L., Charlton,R., Adlard,J., Merchant,W. and Newton-Bishop,J.A.
    Histopathology of melanocytic lesions in a family with an inherited BAP1 mutation
    J Cutan Pathol43, 287-289. PubMed  Europe PubMed DOI  M
  117. Sahtoe,D.D., van Dijk,W.J., Ekkebus,R., Ovaa,H. and Sixma,T.K.
    BAP1/ASXL1 recruitment and activation for H2A deubiquitination
    Nat Commun7, 10292-10292. PubMed  Europe PubMed DOI
  118. Togo,Y., Yoshikawa,Y., Suzuki,T., Nakano,Y., Kanematsu,A., Zozumi,M., Nojima,M., Hirota,S., Yamamoto,S. and Hashimoto-Tamaoki,T.
    Genomic profiling of the genes on chromosome 3p in sporadic clear cell renal cell carcinoma
    Int J Oncol48, 1571-1580. PubMed  Europe PubMed DOI  M
  119. Wang,A., Papneja,A., Hyrcza,M., Al-Habeeb,A. and Ghazarian,D.
    Gene of the month: BAP1
    J Clin Pathol69, 750-753. PubMed  Europe PubMed DOI  M
  120. 2015
  121. Bhattacharya,S., Hanpude,P. and Maiti,T.K.
    Cancer associated missense mutations in BAP1 catalytic domain induce amyloidogenic aggregation: A new insight in enzymatic inactivation
    Sci Rep5, 18462-18462. PubMed  Europe PubMed DOI  M
  122. Carbone,M., Flores,E.G., Emi,M., Johnson,T.A., Tsunoda,T., Behner,D., Hoffman,H., Hesdorffer,M., Nasu,M., Napolitano,A., Powers,A., Minaai,M., Baumann,F., Bryant-Greenwood,P., Lauk,O., Kirschner,M.B., Weder,W., Opitz,I., Pass,H.I., Gaudino,G., Pastorino,S. and Yang,H.
    Combined genetic and genealogic studies uncover a large BAP1 cancer syndrome kindred tracing back nine generations to a common ancestor from the 1700s
    PLoS Genet11, e1005633-e1005633. PubMed  Europe PubMed DOI  M
  123. Daou,S., Hammond-Martel,I., Mashtalir,N., Barbour,H., Gagnon,J., Iannantuono,N.V., Nkwe,N.S., Motorina,A., Pak,H., Yu,H., Wurtele,H., Milot,E., Mallette,F.A., Carbone,M. and Affar,e.B.
    The BAP1/ASXL2 histone H2A deubiquitinase complex regulates cell proliferation and is disrupted in cancer
    J Biol Chem290, 28643-28663. PubMed  Europe PubMed DOI
  124. de la Fouchardiere,A., Cabaret,O., Savin,L., Combemale,P., Schvartz,H., Penet,C., Bonadona,V., Soufir,N. and Bressac-de Paillerets,B.
    Germline BAP1 mutations predispose also to multiple basal cell carcinomas
    Clin Genet88, 273-277. PubMed  Europe PubMed DOI  M
  125. LaFave,L.M., Beguelin,W., Koche,R., Teater,M., Spitzer,B., Chramiec,A., Papalexi,E., Keller,M.D., Hricik,T., Konstantinoff,K., Micol,J.B., Durham,B., Knutson,S.K., Campbell,J.E., Blum,G., Shi,X., Doud,E.H., Krivtsov,A.V., Chung,Y.R., Khodos,I., de Stanchina,E., Ouerfelli,O., Adusumilli,P.S., Thomas,P.M., Kelleher,N.L., Luo,M., Keilhack,H., Abdel-Wahab,O., Melnick,A., Armstrong,S.A. and Levine,R.L.
    Loss of BAP1 function leads to EZH2-dependent transformation
    Nat Med21, 1344-1349. PubMed  Europe PubMed DOI
  126. Pfoh,R., Lacdao,I.K. and Saridakis,V.
    Deubiquitinases and the new therapeutic opportunities offered to cancer
    Endocr Relat Cancer22, T35-T54. PubMed  Europe PubMed DOI  V  T
  127. Piva,F., Giulietti,M., Occhipinti,G., Santoni,M., Massari,F., Sotte,V., Iacovelli,R., Burattini,L., Santini,D., Montironi,R., Cascinu,S. and Principato,G.
    Computational analysis of the mutations in BAP1, PBRM1 and SETD2 genes reveals the impaired molecular processes in renal cell carcinoma
    Oncotarget6, 32161-32168. PubMed  Europe PubMed DOI  M
  128. 2012
  129. Yang,F., Jia,S.N., Yu,Y.Q., Ye,X., Liu,J., Qian,Y.Q. and Yang,W.J.
    Deubiquitinating enzyme BAP1 is involved in the formation and maintenance of the diapause embryos of Artemia
    Cell Stress Chaperones17, 577-587. PubMed  Europe PubMed DOI
  130. Zhou,Z.R., Zhang,Y.H., Liu,S., Song,A.X. and Hu,H.Y.
    Length of the active-site crossover loop defines the substrate specificity of ubiquitin C-terminal hydrolases for ubiquitin chains
    Biochem J441, 143-149. PubMed  Europe PubMed DOI
  131. 2010
  132. Scheuermann,J.C., de Ayala Alonso,A.G., Oktaba,K., Ly-Hartig,N., McGinty,R.K., Fraterman,S., Wilm,M., Muir,T.W. and Muller,J.
    Histone H2A deubiquitinase activity of the Polycomb repressive complex PR-DUB
    Nature465, 243-247. PubMed  Europe PubMed DOI
  133. Yu,H., Mashtalir,N., Daou,S., Hammond-Martel,I., Ross,J., Sui,G., Hart,G.W., Rauscher,F.J., III, Drobetsky,E., Milot,E., Shi,Y. and Affar el,B.
    The ubiquitin carboxyl hydrolase BAP1 forms a ternary complex with YY1 and HCF-1 and is a critical regulator of gene expression
    Mol Cell Biol30, 5071-5085. PubMed  Europe PubMed DOI
  134. 2009
  135. Misaghi,S., Ottosen,S., Izrael-Tomasevic,A., Arnott,D., Lamkanfi,M., Lee,J., Liu,J., O'Rourke,K., Dixit,V.M. and Wilson,A.C.
    Association of C-terminal ubiquitin hydrolase BRCA1-associated protein 1 with cell cycle regulator host cell factor 1
    Mol Cell Biol29, 2181-2192. PubMed  Europe PubMed DOI
  136. Nishikawa,H., Wu,W., Koike,A., Kojima,R., Gomi,H., Fukuda,M. and Ohta,T.
    BRCA1-associated protein 1 interferes with BRCA1/BARD1 RING heterodimer activity
    Cancer Res69, 111-119. PubMed  Europe PubMed DOI
  137. Tse,W.K., Eisenhaber,B., Ho,S.H., Ng,Q., Eisenhaber,F. and Jiang,Y.J.
    Genome-wide loss-of-function analysis of deubiquitylating enzymes for zebrafish development
    BMC Genomics10, 637-637. PubMed  Europe PubMed DOI
  138. 2002
  139. [YEAR:16-12-2002]Mallery,D.L., Vandenberg,C.J. and Hiom,K.
    Activation of the E3 ligase function of the BRCA1/BARD1 complex by polyubiquitin chains
    EMBO J21, 6755-6762. PubMed  Europe PubMed DOI
  140. 1998
  141. [YEAR:5-3-1998]Jensen,D.E., Proctor,M., Marquis,S.T., Gardner,H.P., Ha,S.I., Chodosh,L.A., Ishov,A.M., Tommerup,N., Vissing,H., Sekido,Y., Minna,J., Borodovsky,A., Schultz,D.C., Wilkinson,K.D., Maul,G.G., Barlev,N., Berger,S.L., Prendergast,G.C. and Rauscher,F.J., III
    BAP1: a novel ubiquitin hydrolase which binds to the BRCA1 RING finger and enhances BRCA1-mediated cell growth suppression
    Oncogene16, 1097-1112. PubMed  Europe PubMed