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Literature for peptidase C12.001: ubiquitinyl hydrolase-L1

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Inhibitors

(Topics flags: S Structure, A Assay, T Target, K Knockout, V Review, M Mutation, I Inhibitor, U Therapeutic. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Cao,T.T.T., Nguyen,T.A., Nguyen,M.H.C., Ngo Trang,T.T.H. and Dang,T.T.P.
    Critical roles of Drosophila ubiquitin carboxyl-terminal hydrolase in eye development
    Life Sci Alliance (2025) 8 PubMed  Europe PubMed DOI  PMC  EPMC  K
  2. Lee,G.Y., Jeong,I.H., Kim,B.S., Kim,H.S. and Lee,P.C.
    UCHL1 Promotes Gastric Cancer Progression by Regulating CIP2A Degradation
    Pharmaceuticals (Basel) (2025) 18 PubMed  Europe PubMed DOI  PMC  EPMC  K
  3. Perrier,M., Loreth,D., Brand,J., Aubry,L., Harrison,T., Jacq,X., Tate,E.W., Kipka,G.M., Gersch,M., Meyer-Schwesinger,C., Fauvarque,M.O. and Bouron,A.
    Deubiquitinating Enzyme UCH-L1 Regulates Neuronal Ca(2+) Signaling
    ACS Chem Neurosci (2025) PubMed  Europe PubMed DOI
  4. Wang,Z., Chen,L., Zhang,H., Yan,Z., Liu,K., Qi,J., Lu,B., Yin,Y., Zhao,C., Niu,Y. and Li,W.
    Mechanism of NUMBL Enhancing Axitinib Resistance in Clear Cell Renal Cell Carcinoma by UCHL1-Mediated Deubiquitination of MMP9
    J Biol Chem (2025) , 110873-110873. PubMed  Europe PubMed DOI
  5. Wu,Y., Deng,Y., Ai,Q., Li,Y., Qin,F., Hammad,M., Meng,Z., Xu,X., Wei,J., Yu,H., Liang,G. and Zhao,X.
    Deubiquitinating enzymes in parkinson's disease: molecular mechanisms and therapeutic potential
    Mol Med (2025) 31, 329-329. PubMed  Europe PubMed DOI
  6. Yang,J.J., Liu,H.J., Wang,Y.X., Wang,L.P., Gu,J.J., Gao,J.Y., Ren,K.Q. and Min,L.F.
    Oxidative Stress and Epithelial-Mesenchymal Transition: The Impact of Ubiquitin C-terminal Hydrolase L1 in Cigarette Smoke-Induced COPD
    Lung (2025) 203, 36-36. PubMed  Europe PubMed DOI  K
    7. 2024
  7. Antony,R., Aby,K., Montgomery,M. and Li,Y.
    Skeletal Muscle UCHL1 Negatively Regulates Muscle Development and Recovery after Muscle Injury
    Int J Mol Sci (2024) 25 PubMed  Europe PubMed DOI  PMC  EPMC  K
  8. Buneeva,O. and Medvedev,A.
    Ubiquitin Carboxyl-Terminal Hydrolase L1 and Its Role in Parkinson's Disease
    Int J Mol Sci (2024) 25 PubMed  Europe PubMed DOI  PMC  EPMC
  9. Cheng,J., Liu,H., Shen,Y., Ding,J., He,H., Mao,S., Chen,L., Zhang,C. and Zhou,J.
    Deubiquitinase UCHL1 stabilizes KDM4B to augment VEGF signaling and confer bevacizumab resistance in clear cell renal cell carcinoma
    Transl Oncol (2024) 45, 101987-101987. PubMed  Europe PubMed DOI  PMC  EPMC
  10. Ho,H.H. and Wing,S.S.
    alpha-Synuclein ubiquitination - functions in proteostasis and development of Lewy bodies
    Front Mol Neurosci (2024) 17, 1498459-1498459. PubMed  Europe PubMed DOI  PMC  EPMC  V
  11. Kenny,S., Lai,C.H., Chiang,T.S., Brown,K., Hewitt,C.S., Krabill,A.D., Chang,H.T., Wang,Y.S., Flaherty,D.P., Hsu,S.D. and Das,C.
    Altered Protein Dynamics and a More Reactive Catalytic Cysteine in a Neurodegeneration-associated UCHL1 Mutant
    J Mol Biol (2024) 436, 168438-168438. PubMed  Europe PubMed DOI
  12. Lee,D., Yoon,E., Ham,S.J., Lee,K., Jang,H., Woo,D., Lee,D.H., Kim,S., Choi,S. and Chung,J.
    Diabetic sensory neuropathy and insulin resistance are induced by loss of UCHL1 in Drosophila
    Nat Commun (2024) 15, 468-468. PubMed  Europe PubMed DOI  PMC  EPMC
  13. Liang,W., Feng,R., Li,X., Duan,X., Feng,S., Chen,J., Li,Y., Chen,J., Liu,Z., Wang,X., Ruan,G., Tang,S., Ding,C., Huang,B., Zou,Z. and Chen,T.
    A RANKL-UCHL1-sCD13 negative feedback loop limits osteoclastogenesis in subchondral bone to prevent osteoarthritis progression
    Nat Commun (2024) 15, 8792-8792. PubMed  Europe PubMed DOI  PMC  EPMC
  14. Luo,J., Zhang,J., Zhang,Y., Li,M., Yu,L., Song,D. and Sun,Z.
    Genetic loss of Uchl1 leads to female infertility by affecting oocyte quality and follicular development
    Mol Cell Endocrinol (2024) 597, 112440-112440. PubMed  Europe PubMed DOI
  15. Materozzi,M., Resnati,M., Facchi,C., Trudu,M., Orfanelli,U., Perini,T., Gennari,L., Milan,E. and Cenci,S.
    A novel proteomic signature of osteoclast differentiation unveils the deubiquitinase UCHL1 as a necessary osteoclastogenic driver
    Sci Rep (2024) 14, 7290-7290. PubMed  Europe PubMed DOI  PMC  EPMC
  16. Olie,C.S., O'Brien,D.P., Jones,H.B.L., Liang,Z., Damianou,A., Sur-Erdem,I., Pinto-Fernandez,A., Raz,V. and Kessler,B.M.
    Deubiquitinases in muscle physiology and disorders
    Biochem Soc Trans (2024) 52, 1085-1098. PubMed  Europe PubMed DOI  V
  17. Pan,H., Song,J., An,Q., Chen,J., Zheng,W., Zhang,L., Gu,J., Deng,C. and Yang,B.
    Inhibition of Ubiquitin C-Terminal Hydrolase L1 Facilitates Cutaneous Wound Healing via Activating TGF-beta/Smad Signalling Pathway in Fibroblasts
    Exp Dermatol (2024) 33, e15186-e15186. PubMed  Europe PubMed DOI
  18. Schmidt,M., Grethe,C., Recknagel,S., Kipka,G.M., Klink,N. and Gersch,M.
    N-Cyanopiperazines as Specific Covalent Inhibitors of the Deubiquitinating Enzyme UCHL1
    Angew Chem Int Ed Engl (2024) 63, e202318849-e202318849. PubMed  Europe PubMed DOI
  19. Xu,Z., Zhang,N. and Shi,L.
    Potential roles of UCH family deubiquitinases in tumorigenesis and chemical inhibitors developed against them
    Am J Cancer Res (2024) 14, 2666-2694. PubMed  Europe PubMed DOI  PMC  EPMC  V
    20. 2023
  20. Bednash,J.S., Johns,F., Farkas,D., Elhance,A., Adair,J., Cress,K., Yount,J.S., Kenney,A.D., Londino,J.D. and Mallampalli,R.K.
    Inhibiting the Deubiquitinase UCHL1 Reduces SARS-CoV-2 Viral Uptake by ACE2
    Am J Respir Cell Mol Biol (2023) 68, 566-576. PubMed  Europe PubMed DOI  PMC  EPMC  K
  21. Bouron,A., Aubry,L., Loreth,D., Fauvarque,M.O. and Meyer-Schwesinger,C.
    Role of the deubiquitinating enzyme UCH-L1 in mitochondrial function
    Front Cell Neurosci (2023) 17, 1149954-1149954. PubMed  Europe PubMed DOI  PMC  EPMC
  22. Burkart,S., Weusthof,C., Khorani,K., Steen,S., Stogbauer,F., Unger,K., Hess,J., Zitzelsberger,H., Belka,C., Kurth,I. and Hess,J.
    A Novel Subgroup of UCHL1-Related Cancers Is Associated with Genomic Instability and Sensitivity to DNA-Damaging Treatment
    Cancers (Basel) (2023) 15 PubMed  Europe PubMed DOI  PMC  EPMC
  23. Feng,Z., Tao,S., Huang,Z., Zheng,B., Kong,X., Xiang,Y., Zhang,Q., Song,H., Xu,Z., Wei,X., Zhao,F. and Chen,J.
    The deubiquitinase UCHL1 negatively controls osteoclastogenesis by regulating TAZ/NFATC1 signalling
    Int J Biol Sci (2023) 19, 2319-2332. PubMed  Europe PubMed DOI  PMC  EPMC
  24. Mi,Z. and Graham,S.H.
    Role of UCHL1 in the pathogenesis of neurodegenerative diseases and brain injury
    Ageing Res Rev (2023) 86, 101856-101856. PubMed  Europe PubMed DOI  PMC  EPMC  V
  25. Reichelt,J., Sachs,W., Frombling,S., Fehlert,J., Studencka-Turski,M., Betz,A., Loreth,D., Blume,L., Witt,S., Pohl,S., Brand,J., Czesla,M., Knop,J., Florea,B.I., Zielinski,S., Sachs,M., Hoxha,E., Hermans-Borgmeyer,I., Zahner,G., Wiech,T., Kruger,E. and Meyer-Schwesinger,C.
    Publisher Correction: Non-functional ubiquitin C-terminal hydrolase L1 drives podocyte injury through impairing proteasomes in autoimmune glomerulonephritis
    Nat Commun (2023) 14, 2453-2453. PubMed  Europe PubMed DOI  PMC  EPMC
  26. Reichelt,J., Sachs,W., Frombling,S., Fehlert,J., Studencka-Turski,M., Betz,A., Loreth,D., Blume,L., Witt,S., Pohl,S., Brand,J., Czesla,M., Knop,J., Florea,B.I., Zielinski,S., Sachs,M., Hoxha,E., Hermans-Borgmeyer,I., Zahner,G., Wiech,T., Kruger,E. and Meyer-Schwesinger,C.
    Non-functional ubiquitin C-terminal hydrolase L1 drives podocyte injury through impairing proteasomes in autoimmune glomerulonephritis
    Nat Commun (2023) 14, 2114-2114. PubMed  Europe PubMed DOI  PMC  EPMC
  27. Shi,S., Chu,G., Zhang,L., Yuan,H., Madaniyati,M., Zhou,X., Wang,L., Cai,C., Pang,W., Gao,L. and Yang,G.
    Deubiquitinase UCHL1 regulates estradiol synthesis by stabilizing voltage-dependent anion channel 2
    J Biol Chem (2023) 299, 105316-105316. PubMed  Europe PubMed DOI  PMC  EPMC
  28. Subramaniyan,B., Larabee,J.L., Bodas,M., Moore,A.R., Burgett,A.W.G., Papin,J.F. and Walters,M.S.
    Inhibition of the Cellular Deubiquitinase UCHL1 Suppresses SARS-CoV-2 Replication
    Am J Respir Cell Mol Biol (2023) 69, 367-370. PubMed  Europe PubMed DOI  PMC  EPMC
  29. Zhang,Z. and Das,C.
    Characterization of Deubiquitinase Catalytic State Using a Structure-Based Approach
    Methods Mol Biol (2023) 2591, 1-15. PubMed  Europe PubMed DOI
    30. 2022
  30. Grethe,C., Schmidt,M., Kipka,G.M., O'Dea,R., Gallant,K., Janning,P. and Gersch,M.
    Structural basis for specific inhibition of the deubiquitinase UCHL1
    Nat Commun (2022) 13, 5950-5950. PubMed  Europe PubMed DOI  PMC  EPMC
  31. Huynh,T.K.T., Mai,T.T.T., Huynh,M.A., Yoshida,H., Yamaguchi,M. and Dang,T.T.P.
    Crucial Roles of Ubiquitin Carboxy-Terminal Hydrolase L1 in Motor Neuronal Health by Drosophila Model
    Antioxid Redox Signal (2022) 37, 257-273. PubMed  Europe PubMed DOI  K
  32. Lee,J., Kane,B.J., Khanwalker,M. and Sode,K.
    Development of an electrochemical impedance spectroscopy based biosensor for detection of ubiquitin C-Terminal hydrolase L1
    Biosens Bioelectron (2022) 208, 114232-114232. PubMed  Europe PubMed DOI
    33. 2021
  33. Alpaugh,W.F., Voigt,A.L., Dardari,R., Su,L., Al Khatib,I., Shin,W., Goldsmith,T.M., Coyle,K.M., Tang,L.A., Shutt,T.E., Klein,C., Biernaskie,J. and Dobrinski,I.
    Loss of Ubiquitin Carboxy-Terminal Hydrolase L1 Impairs Long-Term Differentiation Competence and Metabolic Regulation in Murine Spermatogonial Stem Cells
    Cells (2021) 10 PubMed  Europe PubMed DOI  PMC  EPMC
  34. Butterfield,D.A.
    Ubiquitin carboxyl-terminal hydrolase L-1 in brain: Focus on its oxidative/nitrosative modification and role in brains of subjects with Alzheimer disease and mild cognitive impairment
    Free Radic Biol Med (2021) 177, 278-286. PubMed  Europe PubMed DOI
  35. Chiu,Y.H., Ko,K.T., Yang,T.J., Wu,K.P., Ho,M.R., Draczkowski,P. and Hsu,S.D.
    Direct Visualization of a 26 kDa Protein by Cryo-Electron Microscopy Aided by a Small Scaffold Protein
    Biochemistry (2021) 60, 1075-1079. PubMed  Europe PubMed DOI
  36. Fischer,A., Sellner,M., Mitusinska,K., Bzowka,M., Lill,M.A., Gora,A. and Smiesko,M.
    Computational Selectivity Assessment of Protease Inhibitors against SARS-CoV-2
    Int J Mol Sci (2021) 22 PubMed  Europe PubMed DOI  PMC  EPMC
  37. Li,Z., Baccianti,F., Delecluse,S., Tsai,M.H., Shumilov,A., Cheng,X., Ma,S., Hoffmann,I., Poirey,R. and Delecluse,H.J.
    The Epstein-Barr virus noncoding RNA EBER2 transactivates the UCHL1 deubiquitinase to accelerate cell growth
    Proc Natl Acad Sci U S A (2021) 118 PubMed  Europe PubMed DOI
  38. Lu,G., Li,J., Ding,L., Wang,C., Tang,L., Liu,X., Xu,J., Zhou,Q., Sun,J., Wang,W. and Ding,X.
    The Deubiquitinating Enzyme UCHL1 Induces Resistance to Doxorubicin in HER2+ Breast Cancer by Promoting Free Fatty Acid Synthesis
    Front Oncol (2021) 11, 629640-629640. PubMed  Europe PubMed DOI  PMC  EPMC
  39. Mitra,S., Epshtein,Y., Sammani,S., Quijada,H., Chen,W., Bandela,M., Desai,A.A., Garcia,J.G.N. and Jacobson,J.R.
    UCHL1, a Deubiquitinating Enzyme, Regulates Lung Endothelial Cell Permeability In Vitro and In Vivo
    Am J Physiol Lung Cell Mol Physiol (2021) PubMed  Europe PubMed DOI  K  I
  40. Puri,S. and Hsu,S.D.
    Cross-over Loop Cysteine C152 Acts as an Antioxidant to Maintain the Folding Stability and Deubiquitinase Activity of UCH-L1 Under Oxidative Stress
    J Mol Biol (2021) 433, 166879-166879. PubMed  Europe PubMed DOI
  41. Tangri,A., Lighty,K., Loganathan,J., Mesmar,F., Podicheti,R., Zhang,C., Iwanicki,M., Drapkin,R., Nakshatri,H. and Mitra,S.
    Deubiquitinase UCHL1 Maintains Protein Homeostasis through the PSMA7-APEH-Proteasome Axis in High-grade Serous Ovarian Carcinoma
    Mol Cancer Res (2021) PubMed  Europe PubMed DOI
  42. Wang,K.K.W., Kobeissy,F.H., Shakkour,Z. and Tyndall,J.A.
    Thorough overview of ubiquitin C-terminal hydrolase-L1 and glial fibrillary acidic protein as tandem biomarkers recently cleared by US Food and Drug Administration for the evaluation of intracranial injuries among patients with traumatic brain injury
    Acute Med Surg (2021) 8, e622-e622. PubMed  Europe PubMed DOI  PMC  EPMC  V
  43. Wu,D.D., Xu,Y.M., Chen,D.J., Liang,Z.L., Chen,X.L., Hylkema,M.N., Rots,M.G., Li,S.Q. and Lau,A.T.Y.
    Ubiquitin carboxyl-terminal hydrolase isozyme L1/UCHL1 suppresses epithelial-mesenchymal transition and is under-expressed in cadmium-transformed human bronchial epithelial cells
    Cell Biol Toxicol (2021) 37, 497-513. PubMed  Europe PubMed DOI
  44. Zeng,S., Huang,Y., Zhong,T., Huang,T., Dong,X., Zhu,H. and Ouyang,F.
    The expression and clinical value of ubiquitin carboxyl-terminal hydrolase L1 in the blood of neonates with hypoxic ischemic encephalopathy
    Transl Pediatr (2021) 10, 2063-2068. PubMed  Europe PubMed DOI  PMC  EPMC
    45. 2020
  45. Elhady,M., Youness,E.R., AbuShady,M.M., Nassar,M.S., Elaziz,A.A., Masoud,M.M., Foudaa,F.K. and Elhamed,W.A.A.
    Circulating glial fibrillary acidic protein and ubiquitin carboxy-terminal hydrolase-L1 as markers of neuronal damage in children with epileptic seizures
    Childs Nerv Syst (2020) PubMed  Europe PubMed DOI
  46. Gao,H., Antony,R., Srinivasan,R., Wu,P., Wang,X. and Li,Y.
    UCHL1 regulates oxidative activity in skeletal muscle
    PLoS ONE (2020) 15, e0241716-e0241716. PubMed  Europe PubMed DOI  PMC  EPMC
  47. Gui,W., Shen,S. and Zhuang,Z.
    Photocaged Cell-Permeable Ubiquitin Probe for Temporal Profiling of Deubiquitinating Enzymes
    J Am Chem Soc (2020) 142, 19493-19501. PubMed  Europe PubMed DOI
  48. Hewitt,C.S., Krabill,A.D., Das,C. and Flaherty,D.P.
    Development of Ubiquitin Variants with Selectivity for Ubiquitin C-Terminal Hydrolase Deubiquitinases
    Biochemistry (2020) 59, 3447-3462. PubMed  Europe PubMed DOI
  49. Huang,S., Wei,Y.K., Kaliamurthi,S., Cao,Y., Nangraj,A.S., Sui,X., Chu,D., Wang,H., Wei,D.Q., Peslherbe,G.H., Selvaraj,G. and Shi,J.
    Circulating miR-1246 Targeting UBE2C, TNNI3, TRAIP, UCHL1 Genes and Key Pathways as a Potential Biomarker for Lung Adenocarcinoma: Integrated Biological Network Analysis
    J Pers Med (2020) 10 PubMed  Europe PubMed DOI
  50. Kooij,R., Liu,S., Sapmaz,A., Xin,B.T., Janssen,G.M.C., van Veelen,P.A., Ovaa,H., Dijke,P.T. and Geurink,P.P.
    Small-Molecule Activity-Based Probe for Monitoring Ubiquitin C-Terminal Hydrolase L1 (UCHL1) Activity in Live Cells and Zebrafish Embryos
    J Am Chem Soc (2020) 142, 16825-16841. PubMed  Europe PubMed DOI  PMC  EPMC
  51. Lei,Q., Yi,T., Li,H., Yan,Z., Lv,Z., Li,G. and Wang,Y.
    Ubiquitin C-terminal hydrolase L1 (UCHL1) regulates post-myocardial infarction cardiac fibrosis through glucose-regulated protein of 78 kDa (GRP78)
    Sci Rep (2020) 10, 10604-10604. PubMed  Europe PubMed DOI  PMC  EPMC  K
  52. Li,X., Hattori,A., Takahashi,S., Goto,Y., Harada,H. and Kakeya,H.
    Ubiquitin carboxyl-terminal hydrolase L1 promotes hypoxia-inducible factor 1-dependent tumor cell malignancy in spheroid models
    Cancer Sci (2020) 111, 239-252. PubMed  Europe PubMed DOI  I
  53. Liu,S., Gonzalez-Prieto,R., Zhang,M., Geurink,P.P., Kooij,R., Iyengar,P.V., van Dinther,M., Bos,E., Zhang,X., Le Devedec,S.E., van de Water,B., Koning,R.I., Zhu,H.J., Mesker,W.E., Vertegaal,A.C.O., Ovaa,H., Zhang,L., Martens,J.W.M. and ten Dijke,P.
    Deubiquitinase activity profiling identifies UCHL1 as a candidate oncoprotein that promotes TGFbeta-induced breast cancer metastasis
    Clin Cancer Res (2020) 26, 1460-1473. PubMed  Europe PubMed DOI
  54. Mao,R., Tan,X., Xiao,Y., Wang,X., Wei,Z., Wang,J., Wang,X., Zhou,H., Zhang,L. and Shi,Y.
    Ubiquitin C-terminal hydrolase L1 promotes expression of programmed cell death-ligand 1 in non-small-cell lung cancer cells
    Cancer Sci (2020) PubMed  Europe PubMed DOI
  55. Matuszczak,E., Tylicka,M., Komarowska,M.D., Debek,W. and Hermanowicz,A.
    Ubiquitin carboxy-terminal hydrolase L1 - physiology and pathology
    Cell Biochem Funct (2020) PubMed  Europe PubMed DOI
  56. Mehta,T., Fayyaz,M., Giler,G.E., Kaur,H., Raikwar,S.P., Kempuraj,D., Selvakumar,G.P., Ahmed,M.E., Thangavel,R., Zaheer,S., Iyer,S., Govindarajan,R. and Zaheer,A.
    Current Trends in Biomarkers for Traumatic Brain Injury
    Open Access J Neurol Neurosurg (2020) 12, 86-94. PubMed  Europe PubMed  PMC  EPMC  V
  57. Mi,Z., Liu,H., Rose,M.E., Ma,X., Reay,D.P., Ma,J., Henchir,J., Dixon,C.E. and Graham,S.H.
    Abolishing UCHL1's hydrolase activity exacerbates TBI-induced axonal injury and neuronal death in mice
    Exp Neurol (2020) , 113524-113524. PubMed  Europe PubMed DOI
  58. Nawaz,M.S., Asghar,R., Pervaiz,N., Ali,S., Hussain,I., Xing,P., Bao,Y. and Abbasi,A.A.
    Molecular evolutionary and structural analysis of human UCHL1 gene demonstrates the relevant role of intragenic epistasis in Parkinson's disease and other neurological disorders
    BMC Evol Biol (2020) 20, 130-130. PubMed  Europe PubMed DOI  PMC  EPMC
  59. Yasak,I.H., Yilmaz,M., GOnen,M., Atescelik,M., Gurger,M., Ilhan,N. and Goktekin,M.C.
    Evaluation of ubiquitin C-terminal hydrolase-L1 enzyme levels in patients with epilepsy
    Arq Neuropsiquiatr (2020) 78, 424-429. PubMed  Europe PubMed DOI
    60. 2019
  60. Finnerty,B.M., Moore,M., Verma,A., Aronova,A., Huang,S., Edwards,D.P., Chen,Z., Seandel,M., Scognamiglio,T., Du,N., Elemento,O., Zarnegar,R., Min,I.M. and Fahey,T.J.
    UCHL1 loss alters the cell-cycle in metastatic pancreatic neuroendocrine tumors
    Endocr Relat Cancer (2019) 26, 411-423. PubMed  Europe PubMed DOI  M
  61. Reinicke,A.T., Laban,K., Sachs,M., Kraus,V., Walden,M., Damme,M., Sachs,W., Reichelt,J., Schweizer,M., Janiesch,P.C., Duncan,K.E., Saftig,P., Rinschen,M.M., Morellini,F. and Meyer-Schwesinger,C.
    Ubiquitin C-terminal hydrolase L1 (UCH-L1) loss causes neurodegeneration by altering protein turnover in the first postnatal weeks
    Proc Natl Acad Sci U S A (2019) 116, 7963-7972. PubMed  Europe PubMed DOI
    62. 2018
  62. Boisvert,N.C., Holterman,C.E., Thibodeau,J.F., Nasrallah,R., Kamto,E., Comin,C.H., Costa,L.D.F., Carter,A., Hebert,R.L., Gutsol,A., Cron,G.O., Lacoste,B., Gray,D.A. and Kennedy,C.R.
    Hyperfiltration in ubiquitin C-terminal hydrolase L1-deleted mice
    Clin Sci (Lond) (2018) 132, 1453-1470. PubMed  Europe PubMed DOI  K
  63. Das Bhowmik,A., Patil,S.J., Deshpande,D.V., Bhat,V. and Dalal,A.
    Novel splice-site variant of UCHL1 in an Indian family with autosomal recessive spastic paraplegia-79
    J Hum Genet (2018) 63, 927-933. PubMed  Europe PubMed DOI  M
  64. Lee,Y.C. and Hsu,S.D.
    A natively monomeric deubiquitinase UCH-L1 forms highly dynamic but defined metastable oligomeric folding intermediates
    J Phys Chem Lett (2018) 9, 2433-2437. PubMed  Europe PubMed DOI
  65. Song,I.K., Kim,H.J., Magesh,V. and Lee,K.J.
    Ubiquitin C-terminal hydrolase-L1 plays a key role in angiogenesis by regulating hydrogen peroxide generated by NADPH oxidase 4
    Biochem Biophys Res Commun (2018) 495, 1567-1572. PubMed  Europe PubMed DOI
  66. Yan,C., Huo,H., Yang,C., Zhang,T., Chu,Y. and Liu,Y.
    Ubiquitin C-terminal hydrolase L1 regulates autophagy by inhibiting autophagosome formation through its deubiquitinating enzyme activity
    Biochem Biophys Res Commun (2018) 497, 726-733. PubMed  Europe PubMed DOI  M  I
    67. 2017
  67. Guo,Y.Y., Lu,Y., Zheng,Y., Chen,X.R., Dong,J.L., Yuan,R.R., Huang,S.H., Yu,H., Wang,Y., Chen,Z.Y. and Su,B.
    Ubiquitin C-terminal hydrolase L1 (UCH-L1) promotes hippocampus-dependent memory via its deubiquitinating effect on TrkB
    J Neurosci (2017) 37, 5978-5995. PubMed  Europe PubMed DOI
  68. Reynolds,J.P., Jimenez-Mateos,E.M., Cao,L., Bian,F., Alves,M., Miller-Delaney,S.F., Zhou,A. and Henshall,D.C.
    Proteomic analysis after status epilepticus identifies UCHL1 as protective against hippocampal injury
    Neurochem Res (2017) 42, 2033-2054. PubMed  Europe PubMed DOI
  69. Rydning,S.L., Backe,P.H., Sousa,M.M.L., Iqbal,Z., Oye,A.M., Sheng,Y., Yang,M., Lin,X., Slupphaug,G., Nordenmark,T.H., Vigeland,M.D., Bjoras,M., Tallaksen,C.M. and Selmer,K.K.
    Novel UCHL1 mutations reveal new insights into ubiquitin processing
    Hum Mol Genet (2017) 26, 1031-1040. PubMed  Europe PubMed DOI  M
    70. 2016
  70. Bishop,P., Rocca,D. and Henley,J.M.
    Ubiquitin C-terminal hydrolase L1 (UCH-L1): structure, distribution and roles in brain function and dysfunction
    Biochem J (2016) 473, 2453-2462. PubMed  Europe PubMed DOI  V
  71. Christianson,M.S., Gerolstein,A.L., Lee,H.J., Monseur,B.C., Robinson,D.N. and Evans,J.P.
    Effects of ubiquitin C-terminal hydrolase L1 (UCH-L1) inhibition on sperm incorporation and cortical tension in mouse eggs
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