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Literature for peptidase C12.001: ubiquitinyl hydrolase-L1

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

(Topics flags: S Structure, A Assay, T Target, K Knockout, V Review, M Mutation, I Inhibitor, U Therapeutic. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Cao,T.T.T., Nguyen,T.A., Nguyen,M.H.C., Ngo Trang,T.T.H. and Dang,T.T.P.<br>Critical roles of Drosophila ubiquitin carboxyl-terminal hydrolase in eye development<br>Life Sci Alliance (2025) 8 PubMed  Europe PubMed DOI  PMC  EPMC  K
  2. Lee,G.Y., Jeong,I.H., Kim,B.S., Kim,H.S. and Lee,P.C.<br>UCHL1 Promotes Gastric Cancer Progression by Regulating CIP2A Degradation<br>Pharmaceuticals (Basel) (2025) 18 PubMed  Europe PubMed DOI  PMC  EPMC  K
  3. Perrier,M., Loreth,D., Brand,J., Aubry,L., Harrison,T., Jacq,X., Tate,E.W., Kipka,G.M., Gersch,M., Meyer-Schwesinger,C., Fauvarque,M.O. and Bouron,A.<br>Deubiquitinating Enzyme UCH-L1 Regulates Neuronal Ca(2+) Signaling<br>ACS Chem Neurosci (2025) PubMed  Europe PubMed DOI
  4. Wang,Z., Chen,L., Zhang,H., Yan,Z., Liu,K., Qi,J., Lu,B., Yin,Y., Zhao,C., Niu,Y. and Li,W.<br>Mechanism of NUMBL Enhancing Axitinib Resistance in Clear Cell Renal Cell Carcinoma by UCHL1-Mediated Deubiquitination of MMP9<br>J Biol Chem (2025) , 110873-110873. PubMed  Europe PubMed DOI
  5. Wu,Y., Deng,Y., Ai,Q., Li,Y., Qin,F., Hammad,M., Meng,Z., Xu,X., Wei,J., Yu,H., Liang,G. and Zhao,X.<br>Deubiquitinating enzymes in parkinson's disease: molecular mechanisms and therapeutic potential<br>Mol Med (2025) 31, 329-329. PubMed  Europe PubMed DOI
  6. Yang,J.J., Liu,H.J., Wang,Y.X., Wang,L.P., Gu,J.J., Gao,J.Y., Ren,K.Q. and Min,L.F.<br>Oxidative Stress and Epithelial-Mesenchymal Transition: The Impact of Ubiquitin C-terminal Hydrolase L1 in Cigarette Smoke-Induced COPD<br>Lung (2025) 203, 36-36. PubMed  Europe PubMed DOI  K
    7. 2024
  7. Antony,R., Aby,K., Montgomery,M. and Li,Y.<br>Skeletal Muscle UCHL1 Negatively Regulates Muscle Development and Recovery after Muscle Injury<br>Int J Mol Sci (2024) 25 PubMed  Europe PubMed DOI  PMC  EPMC  K
  8. Buneeva,O. and Medvedev,A.<br>Ubiquitin Carboxyl-Terminal Hydrolase L1 and Its Role in Parkinson's Disease<br>Int J Mol Sci (2024) 25 PubMed  Europe PubMed DOI  PMC  EPMC
  9. Cheng,J., Liu,H., Shen,Y., Ding,J., He,H., Mao,S., Chen,L., Zhang,C. and Zhou,J.<br>Deubiquitinase UCHL1 stabilizes KDM4B to augment VEGF signaling and confer bevacizumab resistance in clear cell renal cell carcinoma<br>Transl Oncol (2024) 45, 101987-101987. PubMed  Europe PubMed DOI  PMC  EPMC
  10. Ho,H.H. and Wing,S.S.<br>alpha-Synuclein ubiquitination - functions in proteostasis and development of Lewy bodies<br>Front Mol Neurosci (2024) 17, 1498459-1498459. PubMed  Europe PubMed DOI  PMC  EPMC  V
  11. Kenny,S., Lai,C.H., Chiang,T.S., Brown,K., Hewitt,C.S., Krabill,A.D., Chang,H.T., Wang,Y.S., Flaherty,D.P., Hsu,S.D. and Das,C.<br>Altered Protein Dynamics and a More Reactive Catalytic Cysteine in a Neurodegeneration-associated UCHL1 Mutant<br>J Mol Biol (2024) 436, 168438-168438. PubMed  Europe PubMed DOI
  12. Lee,D., Yoon,E., Ham,S.J., Lee,K., Jang,H., Woo,D., Lee,D.H., Kim,S., Choi,S. and Chung,J.<br>Diabetic sensory neuropathy and insulin resistance are induced by loss of UCHL1 in Drosophila<br>Nat Commun (2024) 15, 468-468. PubMed  Europe PubMed DOI  PMC  EPMC
  13. Liang,W., Feng,R., Li,X., Duan,X., Feng,S., Chen,J., Li,Y., Chen,J., Liu,Z., Wang,X., Ruan,G., Tang,S., Ding,C., Huang,B., Zou,Z. and Chen,T.<br>A RANKL-UCHL1-sCD13 negative feedback loop limits osteoclastogenesis in subchondral bone to prevent osteoarthritis progression<br>Nat Commun (2024) 15, 8792-8792. PubMed  Europe PubMed DOI  PMC  EPMC
  14. Luo,J., Zhang,J., Zhang,Y., Li,M., Yu,L., Song,D. and Sun,Z.<br>Genetic loss of Uchl1 leads to female infertility by affecting oocyte quality and follicular development<br>Mol Cell Endocrinol (2024) 597, 112440-112440. PubMed  Europe PubMed DOI
  15. Materozzi,M., Resnati,M., Facchi,C., Trudu,M., Orfanelli,U., Perini,T., Gennari,L., Milan,E. and Cenci,S.<br>A novel proteomic signature of osteoclast differentiation unveils the deubiquitinase UCHL1 as a necessary osteoclastogenic driver<br>Sci Rep (2024) 14, 7290-7290. PubMed  Europe PubMed DOI  PMC  EPMC
  16. Olie,C.S., O'Brien,D.P., Jones,H.B.L., Liang,Z., Damianou,A., Sur-Erdem,I., Pinto-Fernandez,A., Raz,V. and Kessler,B.M.<br>Deubiquitinases in muscle physiology and disorders<br>Biochem Soc Trans (2024) 52, 1085-1098. PubMed  Europe PubMed DOI  V
  17. Pan,H., Song,J., An,Q., Chen,J., Zheng,W., Zhang,L., Gu,J., Deng,C. and Yang,B.<br>Inhibition of Ubiquitin C-Terminal Hydrolase L1 Facilitates Cutaneous Wound Healing via Activating TGF-beta/Smad Signalling Pathway in Fibroblasts<br>Exp Dermatol (2024) 33, e15186-e15186. PubMed  Europe PubMed DOI
  18. Schmidt,M., Grethe,C., Recknagel,S., Kipka,G.M., Klink,N. and Gersch,M.<br>N-Cyanopiperazines as Specific Covalent Inhibitors of the Deubiquitinating Enzyme UCHL1<br>Angew Chem Int Ed Engl (2024) 63, e202318849-e202318849. PubMed  Europe PubMed DOI
  19. Xu,Z., Zhang,N. and Shi,L.<br>Potential roles of UCH family deubiquitinases in tumorigenesis and chemical inhibitors developed against them<br>Am J Cancer Res (2024) 14, 2666-2694. PubMed  Europe PubMed DOI  PMC  EPMC  V
    20. 2023
  20. Bednash,J.S., Johns,F., Farkas,D., Elhance,A., Adair,J., Cress,K., Yount,J.S., Kenney,A.D., Londino,J.D. and Mallampalli,R.K.<br>Inhibiting the Deubiquitinase UCHL1 Reduces SARS-CoV-2 Viral Uptake by ACE2<br>Am J Respir Cell Mol Biol (2023) 68, 566-576. PubMed  Europe PubMed DOI  PMC  EPMC  K
  21. Bouron,A., Aubry,L., Loreth,D., Fauvarque,M.O. and Meyer-Schwesinger,C.<br>Role of the deubiquitinating enzyme UCH-L1 in mitochondrial function<br>Front Cell Neurosci (2023) 17, 1149954-1149954. PubMed  Europe PubMed DOI  PMC  EPMC
  22. Burkart,S., Weusthof,C., Khorani,K., Steen,S., Stogbauer,F., Unger,K., Hess,J., Zitzelsberger,H., Belka,C., Kurth,I. and Hess,J.<br>A Novel Subgroup of UCHL1-Related Cancers Is Associated with Genomic Instability and Sensitivity to DNA-Damaging Treatment<br>Cancers (Basel) (2023) 15 PubMed  Europe PubMed DOI  PMC  EPMC
  23. Feng,Z., Tao,S., Huang,Z., Zheng,B., Kong,X., Xiang,Y., Zhang,Q., Song,H., Xu,Z., Wei,X., Zhao,F. and Chen,J.<br>The deubiquitinase UCHL1 negatively controls osteoclastogenesis by regulating TAZ/NFATC1 signalling<br>Int J Biol Sci (2023) 19, 2319-2332. PubMed  Europe PubMed DOI  PMC  EPMC
  24. Mi,Z. and Graham,S.H.<br>Role of UCHL1 in the pathogenesis of neurodegenerative diseases and brain injury<br>Ageing Res Rev (2023) 86, 101856-101856. PubMed  Europe PubMed DOI  PMC  EPMC  V
  25. Reichelt,J., Sachs,W., Frombling,S., Fehlert,J., Studencka-Turski,M., Betz,A., Loreth,D., Blume,L., Witt,S., Pohl,S., Brand,J., Czesla,M., Knop,J., Florea,B.I., Zielinski,S., Sachs,M., Hoxha,E., Hermans-Borgmeyer,I., Zahner,G., Wiech,T., Kruger,E. and Meyer-Schwesinger,C.<br>Publisher Correction: Non-functional ubiquitin C-terminal hydrolase L1 drives podocyte injury through impairing proteasomes in autoimmune glomerulonephritis<br>Nat Commun (2023) 14, 2453-2453. PubMed  Europe PubMed DOI  PMC  EPMC
  26. Reichelt,J., Sachs,W., Frombling,S., Fehlert,J., Studencka-Turski,M., Betz,A., Loreth,D., Blume,L., Witt,S., Pohl,S., Brand,J., Czesla,M., Knop,J., Florea,B.I., Zielinski,S., Sachs,M., Hoxha,E., Hermans-Borgmeyer,I., Zahner,G., Wiech,T., Kruger,E. and Meyer-Schwesinger,C.<br>Non-functional ubiquitin C-terminal hydrolase L1 drives podocyte injury through impairing proteasomes in autoimmune glomerulonephritis<br>Nat Commun (2023) 14, 2114-2114. PubMed  Europe PubMed DOI  PMC  EPMC
  27. Shi,S., Chu,G., Zhang,L., Yuan,H., Madaniyati,M., Zhou,X., Wang,L., Cai,C., Pang,W., Gao,L. and Yang,G.<br>Deubiquitinase UCHL1 regulates estradiol synthesis by stabilizing voltage-dependent anion channel 2<br>J Biol Chem (2023) 299, 105316-105316. PubMed  Europe PubMed DOI  PMC  EPMC
  28. Subramaniyan,B., Larabee,J.L., Bodas,M., Moore,A.R., Burgett,A.W.G., Papin,J.F. and Walters,M.S.<br>Inhibition of the Cellular Deubiquitinase UCHL1 Suppresses SARS-CoV-2 Replication<br>Am J Respir Cell Mol Biol (2023) 69, 367-370. PubMed  Europe PubMed DOI  PMC  EPMC
  29. Zhang,Z. and Das,C.<br>Characterization of Deubiquitinase Catalytic State Using a Structure-Based Approach<br>Methods Mol Biol (2023) 2591, 1-15. PubMed  Europe PubMed DOI
    30. 2022
  30. Grethe,C., Schmidt,M., Kipka,G.M., O'Dea,R., Gallant,K., Janning,P. and Gersch,M.<br>Structural basis for specific inhibition of the deubiquitinase UCHL1<br>Nat Commun (2022) 13, 5950-5950. PubMed  Europe PubMed DOI  PMC  EPMC
  31. Huynh,T.K.T., Mai,T.T.T., Huynh,M.A., Yoshida,H., Yamaguchi,M. and Dang,T.T.P.<br>Crucial Roles of Ubiquitin Carboxy-Terminal Hydrolase L1 in Motor Neuronal Health by Drosophila Model<br>Antioxid Redox Signal (2022) 37, 257-273. PubMed  Europe PubMed DOI  K
  32. Lee,J., Kane,B.J., Khanwalker,M. and Sode,K.<br>Development of an electrochemical impedance spectroscopy based biosensor for detection of ubiquitin C-Terminal hydrolase L1<br>Biosens Bioelectron (2022) 208, 114232-114232. PubMed  Europe PubMed DOI
    33. 2021
  33. Alpaugh,W.F., Voigt,A.L., Dardari,R., Su,L., Al Khatib,I., Shin,W., Goldsmith,T.M., Coyle,K.M., Tang,L.A., Shutt,T.E., Klein,C., Biernaskie,J. and Dobrinski,I.<br>Loss of Ubiquitin Carboxy-Terminal Hydrolase L1 Impairs Long-Term Differentiation Competence and Metabolic Regulation in Murine Spermatogonial Stem Cells<br>Cells (2021) 10 PubMed  Europe PubMed DOI  PMC  EPMC
  34. Butterfield,D.A.<br>Ubiquitin carboxyl-terminal hydrolase L-1 in brain: Focus on its oxidative/nitrosative modification and role in brains of subjects with Alzheimer disease and mild cognitive impairment<br>Free Radic Biol Med (2021) 177, 278-286. PubMed  Europe PubMed DOI
  35. Chiu,Y.H., Ko,K.T., Yang,T.J., Wu,K.P., Ho,M.R., Draczkowski,P. and Hsu,S.D.<br>Direct Visualization of a 26 kDa Protein by Cryo-Electron Microscopy Aided by a Small Scaffold Protein<br>Biochemistry (2021) 60, 1075-1079. PubMed  Europe PubMed DOI
  36. Fischer,A., Sellner,M., Mitusinska,K., Bzowka,M., Lill,M.A., Gora,A. and Smiesko,M.<br>Computational Selectivity Assessment of Protease Inhibitors against SARS-CoV-2<br>Int J Mol Sci (2021) 22 PubMed  Europe PubMed DOI  PMC  EPMC
  37. Li,Z., Baccianti,F., Delecluse,S., Tsai,M.H., Shumilov,A., Cheng,X., Ma,S., Hoffmann,I., Poirey,R. and Delecluse,H.J.<br>The Epstein-Barr virus noncoding RNA EBER2 transactivates the UCHL1 deubiquitinase to accelerate cell growth<br>Proc Natl Acad Sci U S A (2021) 118 PubMed  Europe PubMed DOI
  38. Lu,G., Li,J., Ding,L., Wang,C., Tang,L., Liu,X., Xu,J., Zhou,Q., Sun,J., Wang,W. and Ding,X.<br>The Deubiquitinating Enzyme UCHL1 Induces Resistance to Doxorubicin in HER2+ Breast Cancer by Promoting Free Fatty Acid Synthesis<br>Front Oncol (2021) 11, 629640-629640. PubMed  Europe PubMed DOI  PMC  EPMC
  39. Mitra,S., Epshtein,Y., Sammani,S., Quijada,H., Chen,W., Bandela,M., Desai,A.A., Garcia,J.G.N. and Jacobson,J.R.<br>UCHL1, a Deubiquitinating Enzyme, Regulates Lung Endothelial Cell Permeability In Vitro and In Vivo<br>Am J Physiol Lung Cell Mol Physiol (2021) PubMed  Europe PubMed DOI  K  I
  40. Puri,S. and Hsu,S.D.<br>Cross-over Loop Cysteine C152 Acts as an Antioxidant to Maintain the Folding Stability and Deubiquitinase Activity of UCH-L1 Under Oxidative Stress<br>J Mol Biol (2021) 433, 166879-166879. PubMed  Europe PubMed DOI
  41. Tangri,A., Lighty,K., Loganathan,J., Mesmar,F., Podicheti,R., Zhang,C., Iwanicki,M., Drapkin,R., Nakshatri,H. and Mitra,S.<br>Deubiquitinase UCHL1 Maintains Protein Homeostasis through the PSMA7-APEH-Proteasome Axis in High-grade Serous Ovarian Carcinoma<br>Mol Cancer Res (2021) PubMed  Europe PubMed DOI
  42. Wang,K.K.W., Kobeissy,F.H., Shakkour,Z. and Tyndall,J.A.<br>Thorough overview of ubiquitin C-terminal hydrolase-L1 and glial fibrillary acidic protein as tandem biomarkers recently cleared by US Food and Drug Administration for the evaluation of intracranial injuries among patients with traumatic brain injury<br>Acute Med Surg (2021) 8, e622-e622. PubMed  Europe PubMed DOI  PMC  EPMC  V
  43. Wu,D.D., Xu,Y.M., Chen,D.J., Liang,Z.L., Chen,X.L., Hylkema,M.N., Rots,M.G., Li,S.Q. and Lau,A.T.Y.<br>Ubiquitin carboxyl-terminal hydrolase isozyme L1/UCHL1 suppresses epithelial-mesenchymal transition and is under-expressed in cadmium-transformed human bronchial epithelial cells<br>Cell Biol Toxicol (2021) 37, 497-513. PubMed  Europe PubMed DOI
  44. Zeng,S., Huang,Y., Zhong,T., Huang,T., Dong,X., Zhu,H. and Ouyang,F.<br>The expression and clinical value of ubiquitin carboxyl-terminal hydrolase L1 in the blood of neonates with hypoxic ischemic encephalopathy<br>Transl Pediatr (2021) 10, 2063-2068. PubMed  Europe PubMed DOI  PMC  EPMC
    45. 2020
  45. Elhady,M., Youness,E.R., AbuShady,M.M., Nassar,M.S., Elaziz,A.A., Masoud,M.M., Foudaa,F.K. and Elhamed,W.A.A.<br>Circulating glial fibrillary acidic protein and ubiquitin carboxy-terminal hydrolase-L1 as markers of neuronal damage in children with epileptic seizures<br>Childs Nerv Syst (2020) PubMed  Europe PubMed DOI
  46. Gao,H., Antony,R., Srinivasan,R., Wu,P., Wang,X. and Li,Y.<br>UCHL1 regulates oxidative activity in skeletal muscle<br>PLoS ONE (2020) 15, e0241716-e0241716. PubMed  Europe PubMed DOI  PMC  EPMC
  47. Gui,W., Shen,S. and Zhuang,Z.<br>Photocaged Cell-Permeable Ubiquitin Probe for Temporal Profiling of Deubiquitinating Enzymes<br>J Am Chem Soc (2020) 142, 19493-19501. PubMed  Europe PubMed DOI
  48. Hewitt,C.S., Krabill,A.D., Das,C. and Flaherty,D.P.<br>Development of Ubiquitin Variants with Selectivity for Ubiquitin C-Terminal Hydrolase Deubiquitinases<br>Biochemistry (2020) 59, 3447-3462. PubMed  Europe PubMed DOI
  49. Huang,S., Wei,Y.K., Kaliamurthi,S., Cao,Y., Nangraj,A.S., Sui,X., Chu,D., Wang,H., Wei,D.Q., Peslherbe,G.H., Selvaraj,G. and Shi,J.<br>Circulating miR-1246 Targeting UBE2C, TNNI3, TRAIP, UCHL1 Genes and Key Pathways as a Potential Biomarker for Lung Adenocarcinoma: Integrated Biological Network Analysis<br>J Pers Med (2020) 10 PubMed  Europe PubMed DOI
  50. Kooij,R., Liu,S., Sapmaz,A., Xin,B.T., Janssen,G.M.C., van Veelen,P.A., Ovaa,H., Dijke,P.T. and Geurink,P.P.<br>Small-Molecule Activity-Based Probe for Monitoring Ubiquitin C-Terminal Hydrolase L1 (UCHL1) Activity in Live Cells and Zebrafish Embryos<br>J Am Chem Soc (2020) 142, 16825-16841. PubMed  Europe PubMed DOI  PMC  EPMC
  51. Lei,Q., Yi,T., Li,H., Yan,Z., Lv,Z., Li,G. and Wang,Y.<br>Ubiquitin C-terminal hydrolase L1 (UCHL1) regulates post-myocardial infarction cardiac fibrosis through glucose-regulated protein of 78 kDa (GRP78)<br>Sci Rep (2020) 10, 10604-10604. PubMed  Europe PubMed DOI  PMC  EPMC  K
  52. Li,X., Hattori,A., Takahashi,S., Goto,Y., Harada,H. and Kakeya,H.<br>Ubiquitin carboxyl-terminal hydrolase L1 promotes hypoxia-inducible factor 1-dependent tumor cell malignancy in spheroid models<br>Cancer Sci (2020) 111, 239-252. PubMed  Europe PubMed DOI  I
  53. Liu,S., Gonzalez-Prieto,R., Zhang,M., Geurink,P.P., Kooij,R., Iyengar,P.V., van Dinther,M., Bos,E., Zhang,X., Le Devedec,S.E., van de Water,B., Koning,R.I., Zhu,H.J., Mesker,W.E., Vertegaal,A.C.O., Ovaa,H., Zhang,L., Martens,J.W.M. and ten Dijke,P.<br>Deubiquitinase activity profiling identifies UCHL1 as a candidate oncoprotein that promotes TGFbeta-induced breast cancer metastasis<br>Clin Cancer Res (2020) 26, 1460-1473. PubMed  Europe PubMed DOI
  54. Mao,R., Tan,X., Xiao,Y., Wang,X., Wei,Z., Wang,J., Wang,X., Zhou,H., Zhang,L. and Shi,Y.<br>Ubiquitin C-terminal hydrolase L1 promotes expression of programmed cell death-ligand 1 in non-small-cell lung cancer cells<br>Cancer Sci (2020) PubMed  Europe PubMed DOI
  55. Matuszczak,E., Tylicka,M., Komarowska,M.D., Debek,W. and Hermanowicz,A.<br>Ubiquitin carboxy-terminal hydrolase L1 - physiology and pathology<br>Cell Biochem Funct (2020) PubMed  Europe PubMed DOI
  56. Mehta,T., Fayyaz,M., Giler,G.E., Kaur,H., Raikwar,S.P., Kempuraj,D., Selvakumar,G.P., Ahmed,M.E., Thangavel,R., Zaheer,S., Iyer,S., Govindarajan,R. and Zaheer,A.<br>Current Trends in Biomarkers for Traumatic Brain Injury<br>Open Access J Neurol Neurosurg (2020) 12, 86-94. PubMed  Europe PubMed  PMC  EPMC  V
  57. Mi,Z., Liu,H., Rose,M.E., Ma,X., Reay,D.P., Ma,J., Henchir,J., Dixon,C.E. and Graham,S.H.<br>Abolishing UCHL1's hydrolase activity exacerbates TBI-induced axonal injury and neuronal death in mice<br>Exp Neurol (2020) , 113524-113524. PubMed  Europe PubMed DOI
  58. Nawaz,M.S., Asghar,R., Pervaiz,N., Ali,S., Hussain,I., Xing,P., Bao,Y. and Abbasi,A.A.<br>Molecular evolutionary and structural analysis of human UCHL1 gene demonstrates the relevant role of intragenic epistasis in Parkinson's disease and other neurological disorders<br>BMC Evol Biol (2020) 20, 130-130. PubMed  Europe PubMed DOI  PMC  EPMC
  59. Yasak,I.H., Yilmaz,M., GOnen,M., Atescelik,M., Gurger,M., Ilhan,N. and Goktekin,M.C.<br>Evaluation of ubiquitin C-terminal hydrolase-L1 enzyme levels in patients with epilepsy<br>Arq Neuropsiquiatr (2020) 78, 424-429. PubMed  Europe PubMed DOI
    60. 2019
  60. Finnerty,B.M., Moore,M., Verma,A., Aronova,A., Huang,S., Edwards,D.P., Chen,Z., Seandel,M., Scognamiglio,T., Du,N., Elemento,O., Zarnegar,R., Min,I.M. and Fahey,T.J.<br>UCHL1 loss alters the cell-cycle in metastatic pancreatic neuroendocrine tumors<br>Endocr Relat Cancer (2019) 26, 411-423. PubMed  Europe PubMed DOI  M
  61. Reinicke,A.T., Laban,K., Sachs,M., Kraus,V., Walden,M., Damme,M., Sachs,W., Reichelt,J., Schweizer,M., Janiesch,P.C., Duncan,K.E., Saftig,P., Rinschen,M.M., Morellini,F. and Meyer-Schwesinger,C.<br>Ubiquitin C-terminal hydrolase L1 (UCH-L1) loss causes neurodegeneration by altering protein turnover in the first postnatal weeks<br>Proc Natl Acad Sci U S A (2019) 116, 7963-7972. PubMed  Europe PubMed DOI
    62. 2018
  62. Boisvert,N.C., Holterman,C.E., Thibodeau,J.F., Nasrallah,R., Kamto,E., Comin,C.H., Costa,L.D.F., Carter,A., Hebert,R.L., Gutsol,A., Cron,G.O., Lacoste,B., Gray,D.A. and Kennedy,C.R.<br>Hyperfiltration in ubiquitin C-terminal hydrolase L1-deleted mice<br>Clin Sci (Lond) (2018) 132, 1453-1470. PubMed  Europe PubMed DOI  K
  63. Das Bhowmik,A., Patil,S.J., Deshpande,D.V., Bhat,V. and Dalal,A.<br>Novel splice-site variant of UCHL1 in an Indian family with autosomal recessive spastic paraplegia-79<br>J Hum Genet (2018) 63, 927-933. PubMed  Europe PubMed DOI  M
  64. Lee,Y.C. and Hsu,S.D.<br>A natively monomeric deubiquitinase UCH-L1 forms highly dynamic but defined metastable oligomeric folding intermediates<br>J Phys Chem Lett (2018) 9, 2433-2437. PubMed  Europe PubMed DOI
  65. Song,I.K., Kim,H.J., Magesh,V. and Lee,K.J.<br>Ubiquitin C-terminal hydrolase-L1 plays a key role in angiogenesis by regulating hydrogen peroxide generated by NADPH oxidase 4<br>Biochem Biophys Res Commun (2018) 495, 1567-1572. PubMed  Europe PubMed DOI
  66. Yan,C., Huo,H., Yang,C., Zhang,T., Chu,Y. and Liu,Y.<br>Ubiquitin C-terminal hydrolase L1 regulates autophagy by inhibiting autophagosome formation through its deubiquitinating enzyme activity<br>Biochem Biophys Res Commun (2018) 497, 726-733. PubMed  Europe PubMed DOI  M  I
    67. 2017
  67. Guo,Y.Y., Lu,Y., Zheng,Y., Chen,X.R., Dong,J.L., Yuan,R.R., Huang,S.H., Yu,H., Wang,Y., Chen,Z.Y. and Su,B.<br>Ubiquitin C-terminal hydrolase L1 (UCH-L1) promotes hippocampus-dependent memory via its deubiquitinating effect on TrkB<br>J Neurosci (2017) 37, 5978-5995. PubMed  Europe PubMed DOI
  68. Reynolds,J.P., Jimenez-Mateos,E.M., Cao,L., Bian,F., Alves,M., Miller-Delaney,S.F., Zhou,A. and Henshall,D.C.<br>Proteomic analysis after status epilepticus identifies UCHL1 as protective against hippocampal injury<br>Neurochem Res (2017) 42, 2033-2054. PubMed  Europe PubMed DOI
  69. Rydning,S.L., Backe,P.H., Sousa,M.M.L., Iqbal,Z., Oye,A.M., Sheng,Y., Yang,M., Lin,X., Slupphaug,G., Nordenmark,T.H., Vigeland,M.D., Bjoras,M., Tallaksen,C.M. and Selmer,K.K.<br>Novel UCHL1 mutations reveal new insights into ubiquitin processing<br>Hum Mol Genet (2017) 26, 1031-1040. PubMed  Europe PubMed DOI  M
    70. 2016
  70. Bishop,P., Rocca,D. and Henley,J.M.<br>Ubiquitin C-terminal hydrolase L1 (UCH-L1): structure, distribution and roles in brain function and dysfunction<br>Biochem J (2016) 473, 2453-2462. PubMed  Europe PubMed DOI  V
  71. Christianson,M.S., Gerolstein,A.L., Lee,H.J., Monseur,B.C., Robinson,D.N. and Evans,J.P.<br>Effects of ubiquitin C-terminal hydrolase L1 (UCH-L1) inhibition on sperm incorporation and cortical tension in mouse eggs<br>Mol Reprod Dev (2016) 83, 188-189. PubMed  Europe PubMed DOI  I
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