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Literature for peptidase C12.001: ubiquitinyl hydrolase-L1

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

(Topics flags: S Structure, A Assay, T Target, K Knockout, V Review, M Mutation, I Inhibitor, U Therapeutic. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Yang,J.J., Liu,H.J., Wang,Y.X., Wang,L.P., Gu,J.J., Gao,J.Y., Ren,K.Q. and Min,L.F.
    Oxidative Stress and Epithelial-Mesenchymal Transition: The Impact of Ubiquitin C-terminal Hydrolase L1 in Cigarette Smoke-Induced COPD
    Lung203, 36-36. PubMed  Europe PubMed DOI  K
    2. 2024
  2. Antony,R., Aby,K., Montgomery,M. and Li,Y.
    Skeletal Muscle UCHL1 Negatively Regulates Muscle Development and Recovery after Muscle Injury
    Int J Mol Sci25, PubMed  Europe PubMed DOI  K
  3. Buneeva,O. and Medvedev,A.
    Ubiquitin Carboxyl-Terminal Hydrolase L1 and Its Role in Parkinson's Disease
    Int J Mol Sci25, PubMed  Europe PubMed DOI
  4. Cheng,J., Liu,H., Shen,Y., Ding,J., He,H., Mao,S., Chen,L., Zhang,C. and Zhou,J.
    Deubiquitinase UCHL1 stabilizes KDM4B to augment VEGF signaling and confer bevacizumab resistance in clear cell renal cell carcinoma
    Transl Oncol45, 101987-101987. PubMed  Europe PubMed DOI
  5. Ho,H.H. and Wing,S.S.
    alpha-Synuclein ubiquitination - functions in proteostasis and development of Lewy bodies
    Front Mol Neurosci17, 1498459-1498459. PubMed  Europe PubMed DOI  V
  6. Kenny,S., Lai,C.H., Chiang,T.S., Brown,K., Hewitt,C.S., Krabill,A.D., Chang,H.T., Wang,Y.S., Flaherty,D.P., Hsu,S.D. and Das,C.
    Altered Protein Dynamics and a More Reactive Catalytic Cysteine in a Neurodegeneration-associated UCHL1 Mutant
    J Mol Biol436, 168438-168438. PubMed  Europe PubMed DOI
  7. Luo,J., Zhang,J., Zhang,Y., Li,M., Yu,L., Song,D. and Sun,Z.
    Genetic loss of Uchl1 leads to female infertility by affecting oocyte quality and follicular development
    Mol Cell Endocrinol597, 112440-112440. PubMed  Europe PubMed DOI
  8. Materozzi,M., Resnati,M., Facchi,C., Trudu,M., Orfanelli,U., Perini,T., Gennari,L., Milan,E. and Cenci,S.
    A novel proteomic signature of osteoclast differentiation unveils the deubiquitinase UCHL1 as a necessary osteoclastogenic driver
    Sci Rep14, 7290-7290. PubMed  Europe PubMed DOI
  9. Olie,C.S., O'Brien,D.P., Jones,H.B.L., Liang,Z., Damianou,A., Sur-Erdem,I., Pinto-Fernandez,A., Raz,V. and Kessler,B.M.
    Deubiquitinases in muscle physiology and disorders
    Biochem Soc Trans52, 1085-1098. PubMed  Europe PubMed DOI  V
  10. Pan,H., Song,J., An,Q., Chen,J., Zheng,W., Zhang,L., Gu,J., Deng,C. and Yang,B.
    Inhibition of Ubiquitin C-Terminal Hydrolase L1 Facilitates Cutaneous Wound Healing via Activating TGF-beta/Smad Signalling Pathway in Fibroblasts
    Exp Dermatol33, e15186-e15186. PubMed  Europe PubMed DOI
  11. Schmidt,M., Grethe,C., Recknagel,S., Kipka,G.M., Klink,N. and Gersch,M.
    N-Cyanopiperazines as Specific Covalent Inhibitors of the Deubiquitinating Enzyme UCHL1
    Angew Chem Int Ed Engl63, e202318849-e202318849. PubMed  Europe PubMed DOI
  12. Xu,Z., Zhang,N. and Shi,L.
    Potential roles of UCH family deubiquitinases in tumorigenesis and chemical inhibitors developed against them
    Am J Cancer Res14, 2666-2694. PubMed  Europe PubMed DOI  V
    13. 2023
  13. Bednash,J.S., Johns,F., Farkas,D., Elhance,A., Adair,J., Cress,K., Yount,J.S., Kenney,A.D., Londino,J.D. and Mallampalli,R.K.
    Inhibiting the Deubiquitinase UCHL1 Reduces SARS-CoV-2 Viral Uptake by ACE2
    Am J Respir Cell Mol Biol68, 566-576. PubMed  Europe PubMed DOI  K
  14. Bouron,A., Aubry,L., Loreth,D., Fauvarque,M.O. and Meyer-Schwesinger,C.
    Role of the deubiquitinating enzyme UCH-L1 in mitochondrial function
    Front Cell Neurosci17, 1149954-1149954. PubMed  Europe PubMed DOI
  15. Burkart,S., Weusthof,C., Khorani,K., Steen,S., Stogbauer,F., Unger,K., Hess,J., Zitzelsberger,H., Belka,C., Kurth,I. and Hess,J.
    A Novel Subgroup of UCHL1-Related Cancers Is Associated with Genomic Instability and Sensitivity to DNA-Damaging Treatment
    Cancers (Basel)15, PubMed  Europe PubMed DOI
  16. Feng,Z., Tao,S., Huang,Z., Zheng,B., Kong,X., Xiang,Y., Zhang,Q., Song,H., Xu,Z., Wei,X., Zhao,F. and Chen,J.
    The deubiquitinase UCHL1 negatively controls osteoclastogenesis by regulating TAZ/NFATC1 signalling
    Int J Biol Sci19, 2319-2332. PubMed  Europe PubMed DOI
  17. Mi,Z. and Graham,S.H.
    Role of UCHL1 in the pathogenesis of neurodegenerative diseases and brain injury
    Ageing Res Rev86, 101856-101856. PubMed  Europe PubMed DOI  V
  18. Shi,S., Chu,G., Zhang,L., Yuan,H., Madaniyati,M., Zhou,X., Wang,L., Cai,C., Pang,W., Gao,L. and Yang,G.
    Deubiquitinase UCHL1 regulates estradiol synthesis by stabilizing voltage-dependent anion channel 2
    J Biol Chem299, 105316-105316. PubMed  Europe PubMed DOI
  19. Subramaniyan,B., Larabee,J.L., Bodas,M., Moore,A.R., Burgett,A.W.G., Papin,J.F. and Walters,M.S.
    Inhibition of the Cellular Deubiquitinase UCHL1 Suppresses SARS-CoV-2 Replication
    Am J Respir Cell Mol Biol69, 367-370. PubMed  Europe PubMed DOI
  20. Zhang,Z. and Das,C.
    Characterization of Deubiquitinase Catalytic State Using a Structure-Based Approach
    Methods Mol Biol2591, 1-15. PubMed  Europe PubMed DOI
    21. 2022
  21. Huynh,T.K.T., Mai,T.T.T., Huynh,M.A., Yoshida,H., Yamaguchi,M. and Dang,T.T.P.
    Crucial Roles of Ubiquitin Carboxy-Terminal Hydrolase L1 in Motor Neuronal Health by Drosophila Model
    Antioxid Redox Signal37, 257-273. PubMed  Europe PubMed DOI  K
  22. Lee,J., Kane,B.J., Khanwalker,M. and Sode,K.
    Development of an electrochemical impedance spectroscopy based biosensor for detection of ubiquitin C-Terminal hydrolase L1
    Biosens Bioelectron208, 114232-114232. PubMed  Europe PubMed DOI
    23. 2021
  23. Alpaugh,W.F., Voigt,A.L., Dardari,R., Su,L., Al Khatib,I., Shin,W., Goldsmith,T.M., Coyle,K.M., Tang,L.A., Shutt,T.E., Klein,C., Biernaskie,J. and Dobrinski,I.
    Loss of Ubiquitin Carboxy-Terminal Hydrolase L1 Impairs Long-Term Differentiation Competence and Metabolic Regulation in Murine Spermatogonial Stem Cells
    Cells10, PubMed  Europe PubMed DOI
  24. Butterfield,D.A.
    Ubiquitin carboxyl-terminal hydrolase L-1 in brain: Focus on its oxidative/nitrosative modification and role in brains of subjects with Alzheimer disease and mild cognitive impairment
    Free Radic Biol Med177, 278-286. PubMed  Europe PubMed DOI
  25. Chiu,Y.H., Ko,K.T., Yang,T.J., Wu,K.P., Ho,M.R., Draczkowski,P. and Hsu,S.D.
    Direct Visualization of a 26 kDa Protein by Cryo-Electron Microscopy Aided by a Small Scaffold Protein
    Biochemistry60, 1075-1079. PubMed  Europe PubMed DOI
  26. Fischer,A., Sellner,M., Mitusinska,K., Bzowka,M., Lill,M.A., Gora,A. and Smiesko,M.
    Computational Selectivity Assessment of Protease Inhibitors against SARS-CoV-2
    Int J Mol Sci22, PubMed  Europe PubMed DOI
  27. Li,Z., Baccianti,F., Delecluse,S., Tsai,M.H., Shumilov,A., Cheng,X., Ma,S., Hoffmann,I., Poirey,R. and Delecluse,H.J.
    The Epstein-Barr virus noncoding RNA EBER2 transactivates the UCHL1 deubiquitinase to accelerate cell growth
    Proc Natl Acad Sci U S A118, PubMed  Europe PubMed DOI
  28. Lu,G., Li,J., Ding,L., Wang,C., Tang,L., Liu,X., Xu,J., Zhou,Q., Sun,J., Wang,W. and Ding,X.
    The Deubiquitinating Enzyme UCHL1 Induces Resistance to Doxorubicin in HER2+ Breast Cancer by Promoting Free Fatty Acid Synthesis
    Front Oncol11, 629640-629640. PubMed  Europe PubMed DOI
  29. Mitra,S., Epshtein,Y., Sammani,S., Quijada,H., Chen,W., Bandela,M., Desai,A.A., Garcia,J.G.N. and Jacobson,J.R.
    UCHL1, a Deubiquitinating Enzyme, Regulates Lung Endothelial Cell Permeability In Vitro and In Vivo
    Am J Physiol Lung Cell Mol Physiol PubMed  Europe PubMed DOI  K  I
  30. Puri,S. and Hsu,S.D.
    Cross-over Loop Cysteine C152 Acts as an Antioxidant to Maintain the Folding Stability and Deubiquitinase Activity of UCH-L1 Under Oxidative Stress
    J Mol Biol433, 166879-166879. PubMed  Europe PubMed DOI
  31. Tangri,A., Lighty,K., Loganathan,J., Mesmar,F., Podicheti,R., Zhang,C., Iwanicki,M., Drapkin,R., Nakshatri,H. and Mitra,S.
    Deubiquitinase UCHL1 Maintains Protein Homeostasis through the PSMA7-APEH-Proteasome Axis in High-grade Serous Ovarian Carcinoma
    Mol Cancer Res PubMed  Europe PubMed DOI
  32. Wang,K.K.W., Kobeissy,F.H., Shakkour,Z. and Tyndall,J.A.
    Thorough overview of ubiquitin C-terminal hydrolase-L1 and glial fibrillary acidic protein as tandem biomarkers recently cleared by US Food and Drug Administration for the evaluation of intracranial injuries among patients with traumatic brain injury
    Acute Med Surg8, e622-e622. PubMed  Europe PubMed DOI  V
  33. Wu,D.D., Xu,Y.M., Chen,D.J., Liang,Z.L., Chen,X.L., Hylkema,M.N., Rots,M.G., Li,S.Q. and Lau,A.T.Y.
    Ubiquitin carboxyl-terminal hydrolase isozyme L1/UCHL1 suppresses epithelial-mesenchymal transition and is under-expressed in cadmium-transformed human bronchial epithelial cells
    Cell Biol Toxicol37, 497-513. PubMed  Europe PubMed DOI
  34. Zeng,S., Huang,Y., Zhong,T., Huang,T., Dong,X., Zhu,H. and Ouyang,F.
    The expression and clinical value of ubiquitin carboxyl-terminal hydrolase L1 in the blood of neonates with hypoxic ischemic encephalopathy
    Transl Pediatr10, 2063-2068. PubMed  Europe PubMed DOI
    35. 2020
  35. Elhady,M., Youness,E.R., AbuShady,M.M., Nassar,M.S., Elaziz,A.A., Masoud,M.M., Foudaa,F.K. and Elhamed,W.A.A.
    Circulating glial fibrillary acidic protein and ubiquitin carboxy-terminal hydrolase-L1 as markers of neuronal damage in children with epileptic seizures
    Childs Nerv Syst PubMed  Europe PubMed DOI
  36. Gao,H., Antony,R., Srinivasan,R., Wu,P., Wang,X. and Li,Y.
    UCHL1 regulates oxidative activity in skeletal muscle
    PLoS ONE15, e0241716-e0241716. PubMed  Europe PubMed DOI
  37. Gui,W., Shen,S. and Zhuang,Z.
    Photocaged Cell-Permeable Ubiquitin Probe for Temporal Profiling of Deubiquitinating Enzymes
    J Am Chem Soc142, 19493-19501. PubMed  Europe PubMed DOI
  38. Hewitt,C.S., Krabill,A.D., Das,C. and Flaherty,D.P.
    Development of Ubiquitin Variants with Selectivity for Ubiquitin C-Terminal Hydrolase Deubiquitinases
    Biochemistry59, 3447-3462. PubMed  Europe PubMed DOI
  39. Huang,S., Wei,Y.K., Kaliamurthi,S., Cao,Y., Nangraj,A.S., Sui,X., Chu,D., Wang,H., Wei,D.Q., Peslherbe,G.H., Selvaraj,G. and Shi,J.
    Circulating miR-1246 Targeting UBE2C, TNNI3, TRAIP, UCHL1 Genes and Key Pathways as a Potential Biomarker for Lung Adenocarcinoma: Integrated Biological Network Analysis
    J Pers Med10, PubMed  Europe PubMed DOI
  40. Kooij,R., Liu,S., Sapmaz,A., Xin,B.T., Janssen,G.M.C., van Veelen,P.A., Ovaa,H., Dijke,P.T. and Geurink,P.P.
    Small-Molecule Activity-Based Probe for Monitoring Ubiquitin C-Terminal Hydrolase L1 (UCHL1) Activity in Live Cells and Zebrafish Embryos
    J Am Chem Soc142, 16825-16841. PubMed  Europe PubMed DOI
  41. Lei,Q., Yi,T., Li,H., Yan,Z., Lv,Z., Li,G. and Wang,Y.
    Ubiquitin C-terminal hydrolase L1 (UCHL1) regulates post-myocardial infarction cardiac fibrosis through glucose-regulated protein of 78 kDa (GRP78)
    Sci Rep10, 10604-10604. PubMed  Europe PubMed DOI  K
  42. Li,X., Hattori,A., Takahashi,S., Goto,Y., Harada,H. and Kakeya,H.
    Ubiquitin carboxyl-terminal hydrolase L1 promotes hypoxia-inducible factor 1-dependent tumor cell malignancy in spheroid models
    Cancer Sci111, 239-252. PubMed  Europe PubMed DOI  I
  43. Liu,S., Gonzalez-Prieto,R., Zhang,M., Geurink,P.P., Kooij,R., Iyengar,P.V., van Dinther,M., Bos,E., Zhang,X., Le Devedec,S.E., van de Water,B., Koning,R.I., Zhu,H.J., Mesker,W.E., Vertegaal,A.C.O., Ovaa,H., Zhang,L., Martens,J.W.M. and ten Dijke,P.
    Deubiquitinase activity profiling identifies UCHL1 as a candidate oncoprotein that promotes TGFbeta-induced breast cancer metastasis
    Clin Cancer Res26, 1460-1473. PubMed  Europe PubMed DOI
  44. Mao,R., Tan,X., Xiao,Y., Wang,X., Wei,Z., Wang,J., Wang,X., Zhou,H., Zhang,L. and Shi,Y.
    Ubiquitin C-terminal hydrolase L1 promotes expression of programmed cell death-ligand 1 in non-small-cell lung cancer cells
    Cancer Sci PubMed  Europe PubMed DOI
  45. Matuszczak,E., Tylicka,M., Komarowska,M.D., Debek,W. and Hermanowicz,A.
    Ubiquitin carboxy-terminal hydrolase L1 - physiology and pathology
    Cell Biochem Funct PubMed  Europe PubMed DOI
  46. Mehta,T., Fayyaz,M., Giler,G.E., Kaur,H., Raikwar,S.P., Kempuraj,D., Selvakumar,G.P., Ahmed,M.E., Thangavel,R., Zaheer,S., Iyer,S., Govindarajan,R. and Zaheer,A.
    Current Trends in Biomarkers for Traumatic Brain Injury
    Open Access J Neurol Neurosurg12, 86-94. PubMed  Europe PubMed  V
  47. Mi,Z., Liu,H., Rose,M.E., Ma,X., Reay,D.P., Ma,J., Henchir,J., Dixon,C.E. and Graham,S.H.
    Abolishing UCHL1's hydrolase activity exacerbates TBI-induced axonal injury and neuronal death in mice
    Exp Neurol113524-113524. PubMed  Europe PubMed DOI
  48. Nawaz,M.S., Asghar,R., Pervaiz,N., Ali,S., Hussain,I., Xing,P., Bao,Y. and Abbasi,A.A.
    Molecular evolutionary and structural analysis of human UCHL1 gene demonstrates the relevant role of intragenic epistasis in Parkinson's disease and other neurological disorders
    BMC Evol Biol20, 130-130. PubMed  Europe PubMed DOI
  49. Yasak,I.H., Yilmaz,M., GOnen,M., Atescelik,M., Gurger,M., Ilhan,N. and Goktekin,M.C.
    Evaluation of ubiquitin C-terminal hydrolase-L1 enzyme levels in patients with epilepsy
    Arq Neuropsiquiatr78, 424-429. PubMed  Europe PubMed DOI
    50. 2019
  50. Finnerty,B.M., Moore,M., Verma,A., Aronova,A., Huang,S., Edwards,D.P., Chen,Z., Seandel,M., Scognamiglio,T., Du,N., Elemento,O., Zarnegar,R., Min,I.M. and Fahey,T.J.
    UCHL1 loss alters the cell-cycle in metastatic pancreatic neuroendocrine tumors
    Endocr Relat Cancer26, 411-423. PubMed  Europe PubMed DOI  M
  51. Reinicke,A.T., Laban,K., Sachs,M., Kraus,V., Walden,M., Damme,M., Sachs,W., Reichelt,J., Schweizer,M., Janiesch,P.C., Duncan,K.E., Saftig,P., Rinschen,M.M., Morellini,F. and Meyer-Schwesinger,C.
    Ubiquitin C-terminal hydrolase L1 (UCH-L1) loss causes neurodegeneration by altering protein turnover in the first postnatal weeks
    Proc Natl Acad Sci U S A116, 7963-7972. PubMed  Europe PubMed DOI
    52. 2018
  52. Boisvert,N.C., Holterman,C.E., Thibodeau,J.F., Nasrallah,R., Kamto,E., Comin,C.H., Costa,L.D.F., Carter,A., Hebert,R.L., Gutsol,A., Cron,G.O., Lacoste,B., Gray,D.A. and Kennedy,C.R.
    Hyperfiltration in ubiquitin C-terminal hydrolase L1-deleted mice
    Clin Sci (Lond)132, 1453-1470. PubMed  Europe PubMed DOI  K
  53. Das Bhowmik,A., Patil,S.J., Deshpande,D.V., Bhat,V. and Dalal,A.
    Novel splice-site variant of UCHL1 in an Indian family with autosomal recessive spastic paraplegia-79
    J Hum Genet63, 927-933. PubMed  Europe PubMed DOI  M
  54. Lee,Y.C. and Hsu,S.D.
    A natively monomeric deubiquitinase UCH-L1 forms highly dynamic but defined metastable oligomeric folding intermediates
    J Phys Chem Lett9, 2433-2437. PubMed  Europe PubMed DOI
  55. Song,I.K., Kim,H.J., Magesh,V. and Lee,K.J.
    Ubiquitin C-terminal hydrolase-L1 plays a key role in angiogenesis by regulating hydrogen peroxide generated by NADPH oxidase 4
    Biochem Biophys Res Commun495, 1567-1572. PubMed  Europe PubMed DOI
  56. Yan,C., Huo,H., Yang,C., Zhang,T., Chu,Y. and Liu,Y.
    Ubiquitin C-terminal hydrolase L1 regulates autophagy by inhibiting autophagosome formation through its deubiquitinating enzyme activity
    Biochem Biophys Res Commun497, 726-733. PubMed  Europe PubMed DOI  M  I
    57. 2017
  57. Guo,Y.Y., Lu,Y., Zheng,Y., Chen,X.R., Dong,J.L., Yuan,R.R., Huang,S.H., Yu,H., Wang,Y., Chen,Z.Y. and Su,B.
    Ubiquitin C-terminal hydrolase L1 (UCH-L1) promotes hippocampus-dependent memory via its deubiquitinating effect on TrkB
    J Neurosci37, 5978-5995. PubMed  Europe PubMed DOI
  58. Reynolds,J.P., Jimenez-Mateos,E.M., Cao,L., Bian,F., Alves,M., Miller-Delaney,S.F., Zhou,A. and Henshall,D.C.
    Proteomic analysis after status epilepticus identifies UCHL1 as protective against hippocampal injury
    Neurochem Res42, 2033-2054. PubMed  Europe PubMed DOI
  59. Rydning,S.L., Backe,P.H., Sousa,M.M.L., Iqbal,Z., Oye,A.M., Sheng,Y., Yang,M., Lin,X., Slupphaug,G., Nordenmark,T.H., Vigeland,M.D., Bjoras,M., Tallaksen,C.M. and Selmer,K.K.
    Novel UCHL1 mutations reveal new insights into ubiquitin processing
    Hum Mol Genet26, 1031-1040. PubMed  Europe PubMed DOI  M
    60. 2016
  60. Bishop,P., Rocca,D. and Henley,J.M.
    Ubiquitin C-terminal hydrolase L1 (UCH-L1): structure, distribution and roles in brain function and dysfunction
    Biochem J473, 2453-2462. PubMed  Europe PubMed DOI  V
  61. Christianson,M.S., Gerolstein,A.L., Lee,H.J., Monseur,B.C., Robinson,D.N. and Evans,J.P.
    Effects of ubiquitin C-terminal hydrolase L1 (UCH-L1) inhibition on sperm incorporation and cortical tension in mouse eggs
    Mol Reprod Dev83, 188-189. PubMed  Europe PubMed DOI  I
  62. Genc,B., Jara,J.H., Schultz,M.C., Manuel,M., Stanford,M.J., Gautam,M., Klessner,J.L., Sekerkova,G., Heller,D.B., Cox,G.A., Heckman,C.J., DiDonato,C.J. and Ozdinler,P.H.
    Absence of UCHL 1 function leads to selective motor neuropathy
    Ann Clin Transl Neurol3, 331-345. PubMed  Europe PubMed DOI  K  M
  63. Graham,S.H.
    Modification of ubiquitin C-terminal hydrolase L1 by reactive lipid species: role in neural regeneration and diseases of aging
    Neural Regen Res11, 908-909. PubMed  Europe PubMed DOI
  64. Lou,S.C., Wetzel,S., Zhang,H., Crone,E.W., Lee,Y.T., Jackson,S.E. and Hsu,S.T.
    The knotted protein UCH-L1 exhibits partially unfolded forms under native conditions that share common structural features with its kinetic folding intermediates
    J Mol Biol428, 2507-2520. PubMed  Europe PubMed DOI
  65. Ronau,J.A., Beckmann,J.F. and Hochstrasser,M.
    Substrate specificity of the ubiquitin and Ubl proteases
    Cell Res26, 441-456. PubMed  Europe PubMed DOI
  66. Xie,M., Han,Y., Yu,Q., Wang,X., Wang,S. and Liao,X.
    UCH-L1 inhibition decreases the microtubule-binding function of tau protein
    J Alzheimers Dis49, 353-363. PubMed  Europe PubMed DOI  I
  67. Ziegler,F., Lim,N.C., Mandal,S.S., Pelz,B., Ng,W.P., Schlierf,M., Jackson,S.E. and Rief,M.
    Knotting and unknotting of a protein in single molecule experiments
    Proc Natl Acad Sci U S A113, 7533-7538. PubMed  Europe PubMed DOI
    68. 2015
  68. Goto,Y., Zeng,L., Yeom,C.J., Zhu,Y., Morinibu,A., Shinomiya,K., Kobayashi,M., Hirota,K., Itasaka,S., Yoshimura,M., Tanimoto,K., Torii,M., Sowa,T., Menju,T., Sonobe,M., Kakeya,H., Toi,M., Date,H., Hammond,E.M., Hiraoka,M. and Harada,H.
    UCHL1 provides diagnostic and antimetastatic strategies due to its deubiquitinating effect on HIF-1alpha
    Nat Commun6, 6153-6153. PubMed  Europe PubMed DOI
  69. Liu,H., Li,W., Rose,M.E., Hickey,R.W., Chen,J., Uechi,G.T., Balasubramani,M., Day,B.W., Patel,K.V. and Graham,S.H.
    The point mutation UCH-L1 C152A protects primary neurons against cyclopentenone prostaglandin-induced cytotoxicity: implications for post-ischemic neuronal injury
    Cell Death Dis6, e1966-e1966. PubMed  Europe PubMed DOI  M
  70. Liu,Y., Chen,Y.Y., Liu,H., Yao,C.J., Zhu,X.X., Chen,D.J., Yang,J., Lu,Y.J. and Cao,J.Y.
    Association between ubiquitin carboxy-terminal hydrolase-L1 S18Y variant and risk of Parkinson's disease: the impact of ethnicity and onset age
    Neurol Sci36, 179-188. PubMed  Europe PubMed DOI  M
  71. Pfoh,R., Lacdao,I.K. and Saridakis,V.
    Deubiquitinases and the new therapeutic opportunities offered to cancer
    Endocr Relat Cancer22, T35-T54. PubMed  Europe PubMed DOI  V  T
  72. Pukass,K. and Richter-Landsberg,C.
    Inhibition of UCH-L1 in oligodendroglial cells results in microtubule stabilization and prevents alpha-synuclein aggregate formation by activating the autophagic pathway: implications for multiple system atrophy
    Front Cell Neurosci9, 163-163. PubMed  Europe PubMed DOI  I
  73. Sankiewicz,A., Laudanski,P., Romanowicz,L., Hermanowicz,A., Roszkowska-Jakimiec,W., Debek,W. and Gorodkiewicz,E.
    Development of surface plasmon resonance imaging biosensors for detection of ubiquitin carboxyl-terminal hydrolase L1
    Anal Biochem469C, 4-11. PubMed  Europe PubMed DOI  A  I
  74. Toyama,T., Abiko,Y., Katayama,Y., Kaji,T. and Kumagai,Y.
    S-Mercuration of ubiquitin carboxyl-terminal hydrolase L1 through Cys152 by methylmercury causes inhibition of its catalytic activity and reduction of monoubiquitin levels in SH-SY5Y cells
    J Toxicol Sci40, 887-893. PubMed  Europe PubMed DOI  I
    75. 2014
  75. Bishop,P., Rubin,P., Thomson,A.R., Rocca,D. and Henley,J.M.
    The ubiquitin C-terminal hydrolase L1 (UCH-L1) C terminus plays a key role in protein stability, but its farnesylation is not required for membrane association in primary neurons
    J Biol Chem289, 36140-36149. PubMed  Europe PubMed DOI
  76. Contu,V.R., Kotake,Y., Toyama,T., Okuda,K., Miyara,M., Sakamoto,S., Samizo,S., Sanoh,S., Kumagai,Y. and Ohta,S.
    Endogenous neurotoxic dopamine derivative covalently binds to Parkinson's disease-associated ubiquitin C-terminal hydrolase L1 and alters its structure and function
    J Neurochem130, 826-838. PubMed  Europe PubMed DOI
  77. Coulombe,J., Gamage,P., Gray,M.T., Zhang,M., Tang,M.Y., Woulfe,J., Saffrey,M.J. and Gray,D.A.
    Loss of UCHL1 promotes age-related degenerative changes in the enteric nervous system
    Front Aging Neurosci6, 129-129. PubMed  Europe PubMed DOI  K  M
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