Literature for C101.001

(Topics flags: S Structure, A Assay, M Mutation, K Knockout, P Specificity, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

2025
1. Li,L., Li,M., Zhou,Y., Kakhniashvili,D., Wang,X. and Liao,F.F.
   OTULIN Interactome Reveals Immune Response and Autophagy Associated with Tauopathy in a Mouse Model
   bioRxiv PubMed  Europe PubMed DOI
2024
2. Caballero-Oteyza,A., Crisponi,L., Peng,X.P., Wang,H., Mrovecova,P., Olla,S., Siguri,C., Marnissi,F., Jouhadi,Z., Aksentijevich,I., Grimbacher,B. and Proietti,M.
   OTULIN-related conditions: Report of a new case and review of the literature using GenIA
   Res Sq PubMed  Europe PubMed DOI
3. Caballero-Oteyza,A., Crisponi,L., Peng,X.P., Wang,H., Mrovecova,P., Olla,S., Siguri,C., Marnissi,F., Jouhadi,Z., Aksentijevich,I., Grimbacher,B. and Proietti,M.
   OTULIN-related conditions: Report of a new case and review of the literature using GenIA
   Clin Immunol265, 110292-110292. PubMed  Europe PubMed DOI
4. Davidson,S., Shibata,Y., Collard,S., Zheng,H., Kong,K., Sun,J.M., Laohamonthonkul,P., Cerra,A., Kratina,T., Li,M.W.Y., Russell,C., van Beek,A., Kirk,E.P., Walsh,R., Alqanatish,J., Almojali,A., Alsuwairi,W., Alrasheed,A., Lalaoui,N., Gray,P.E., Komander,D. and Masters,S.L.
   Dominant negative OTULIN-related autoinflammatory syndrome
   J Exp Med221, PubMed  Europe PubMed DOI
5. Wang,Q., Wang,L., Botchway,B.O.A., Zhang,Y., Huang,M. and Liu,X.
   OTULIN Can Improve Spinal Cord Injury by the NF-kappaB and Wnt/beta-Catenin Signaling Pathways
   Mol Neurobiol61, 8820-8830. PubMed  Europe PubMed DOI  V
2023
6. Almeida,S.M., Ivantsiv,S., Niibori,R., Dunham,W.H., Green,B.A., Zhao,L., Gingras,A.C. and Cordes,S.P.
   An interaction between OTULIN and SCRIB uncovers roles for linear ubiquitination in planar cell polarity
   Dis Model Mech16, PubMed  Europe PubMed DOI
2022
7. Erol,A.
   Genotoxicity-Stimulated and CYLD-Driven Malignant Transformation
   Cancer Manag Res14, 2339-2356. PubMed  Europe PubMed DOI
8. Li,M., Li,L., Asemota,S., Kakhniashvili,D., Narayanan,R., Wang,X. and Liao,F.F.
   Reciprocal interplay between OTULIN-LUBAC determines genotoxic and inflammatory NF-kappaB signal responses
   Proc Natl Acad Sci U S A119, e2123097119-e2123097119. PubMed  Europe PubMed DOI
9. Spaan,A.N., Neehus,A.L., Laplantine,E., Staels,F., Ogishi,M., Seeleuthner,Y., Rapaport,F., Lacey,K.A., Van Nieuwenhove,E., Chrabieh,M., Hum,D., Migaud,M., Izmiryan,A., Lorenzo,L., Kochetkov,T., Heesterbeek,D.A.C., Bardoel,B.W., DuMont,A.L., Dobbs,K., Chardonnet,S., Heissel,S., Baslan,T., Zhang,P., Yang,R., Bogunovic,D., Wunderink,H.F., Haas,P.A., Molina,H., Van Buggenhout,G., Lyonnet,S., Notarangelo,L.D., Seppanen,M.R.J., Weil,R., Seminario,G., Gomez-Tello,H., Wouters,C., Mesdaghi,M., Shahrooei,M., Bossuyt,X., Sag,E., Topaloglu,R., Ozen,S., Leavis,H.L., van Eijk,M.M.J., Bezrodnik,L., Blancas Galicia,L., Hovnanian,A., Nassif,A., Bader-Meunier,B., Neven,B., Meyts,I., Schrijvers,R., Puel,A., Bustamante,J., Aksentijevich,I., Kastner,D.L., Torres,V.J., Humblet-Baron,S., Liston,A., Abel,L., Boisson,B. and Casanova,J.L.
   Human OTULIN haploinsufficiency impairs cell-intrinsic immunity to staphylococcal alpha-toxin
   Science376, eabm6380-eabm6380. PubMed  Europe PubMed DOI
2021
10. Fu,Y., Wang,H., Dai,H., Zhu,Q., Cui,C.P., Sun,X., Li,Y., Deng,Z., Zhou,X., Ge,Y., Peng,Z., Yuan,C., Wu,B., Yang,X., Li,R., Liu,C.H., He,F., Wei,W. and Zhang,L.
    OTULIN allies with LUBAC to govern angiogenesis by editing ALK1 linear polyubiquitin
    Mol Cell PubMed  Europe PubMed DOI
11. Hoste,E., Lecomte,K., Annusver,K., Vandamme,N., Roels,J., Maschalidi,S., Verboom,L., Vikkula,H.K., Sze,M., Van Hove,L., Verstaen,K., Martens,A., Hochepied,T., Saeys,Y., Ravichandran,K., Kasper,M. and Van Loo,G.
    OTULIN maintains skin homeostasis by controlling keratinocyte death and stem cell identity
    Nat Commun12, 5913-5913. PubMed  Europe PubMed DOI
12. Raja,R. and Sen,G.C.
    The antiviral action of the RIG-I induced pathway of apoptosis (RIPA) is enhanced by its ability to degrade Otulin, which deubiquitinates IRF3
    Cell Death Differ PubMed  Europe PubMed DOI
13. Schunke,H., Gobel,U., Dikic,I. and Pasparakis,M.
    OTULIN inhibits RIPK1-mediated keratinocyte necroptosis to prevent skin inflammation in mice
    Nat Commun12, 5912-5912. PubMed  Europe PubMed DOI
14. Shi,R., Shi,X., Qin,D., Tang,S., Vermeulen,M. and Zhang,X.
    SNX27-driven membrane localisation of OTULIN antagonises linear ubiquitination and NF-kappaB signalling activation
    Cell Biosci11, 146-146. PubMed  Europe PubMed DOI
15. Snyder,N.A. and Silva,G.M.
    Deubiquitinating enzymes (DUBs): Regulation, homeostasis, and oxidative stress response
    J Biol Chem297, 101077-101077. PubMed  Europe PubMed DOI  V
16. ten Dijke,P. and Baker,D.
    Fine-tuning ALK1 linear polyubiquitination to control angiogenesis
    Trends Cell Biol31, 705-707. PubMed  Europe PubMed DOI
17. Verboom,L., Hoste,E. and Van Loo,G.
    OTULIN in NF-kappaB signaling, cell death, and disease
    Trends Immunol42, 590-603. PubMed  Europe PubMed DOI  V
18. Weinelt,N. and van Wijk,S.J.L.
    Ubiquitin-dependent and -independent functions of OTULIN in cell fate control and beyond
    Cell Death Differ28, 493-504. PubMed  Europe PubMed DOI
19. Xu,H., Wang,Y. and Luo,Y.
    OTULIN is a new target of EA treatment in the alleviation of brain injury and glial cell activation via suppression of the NF-kappaB signalling pathway in acute ischaemic stroke rats
    Mol Med27, 37-37. PubMed  Europe PubMed DOI
2020
20. Chu,Y., Kang,Y., Yan,C., Yang,C., Zhang,T., Huo,H. and Liu,Y.
    LUBAC and OTULIN regulate autophagy initiation and maturation by mediating the linear ubiquitination and the stabilization of ATG13
    Autophagy1-16. PubMed  Europe PubMed DOI
21. Damgaard,R.B., Jolin,H.E., Allison,M.E.D., Davies,S.E., Titheradge,H.L., McKenzie,A.N.J. and Komander,D.
    OTULIN protects the liver against cell death, inflammation, fibrosis, and cancer
    Cell Death Differ27, 1457-1474. PubMed  Europe PubMed DOI
22. Douglas,T. and Saleh,M.
    The plot thickens: OTULIN regulation in cell death
    Mol Cell Oncol7, 1740541-1740541. PubMed  Europe PubMed DOI
23. Oikawa,D., Hatanaka,N., Suzuki,T. and Tokunaga,F.
    Cellular and Mathematical Analyses of LUBAC Involvement in T Cell Receptor-Mediated NF-kappaB Activation Pathway
    Front Immunol11, 601926-601926. PubMed  Europe PubMed DOI
24. Verboom,L., Martens,A., Priem,D., Hoste,E., Sze,M., Vikkula,H., Van Hove,L., Voet,S., Roels,J., Maelfait,J., Bongiovanni,L., de Bruin,A., Scott,C.L., Saeys,Y., Pasparakis,M., Bertrand,M.J.M. and Van Loo,G.
    OTULIN Prevents liver inflammation and hepatocellular carcinoma by inhibiting FADD- and RIPK1 kinase-mediated hepatocyte apoptosis
    Cell Rep30, 2237-2247. PubMed  Europe PubMed DOI
25. Wang,W., Li,M., Ponnusamy,S., Chi,Y., Xue,J., Fahmy,B., Fan,M., Miranda-Carboni,G.A., Narayanan,R., Wu,J. and Wu,Z.H.
    ABL1-dependent OTULIN phosphorylation promotes genotoxic Wnt/beta-catenin activation to enhance drug resistance in breast cancers
    Nat Commun11, 3965-3965. PubMed  Europe PubMed DOI
26. Wang,W. and Wu,Z.H.
    OTULIN couples WNT signaling to resistance in triple-negative breast cancer
    Mol Cell Oncol7, 1825904-1825904. PubMed  Europe PubMed DOI
2019
27. Douglas,T. and Saleh,M.
    Post-translational modification of OTULIN regulates ubiquitin dynamics and cell death
    Cell Rep29, 3652-3663. PubMed  Europe PubMed DOI  P
28. Nabavi,M., Shahrooei,M., Rokni-Zadeh,H., Vrancken,J., Changi-Ashtiani,M., Darabi,K., Manian,M., Seif,F., Meyts,I., Voet,A., Moens,L. and Bossuyt,X.
    Auto-inflammation in a patient with a novel homozygous OTULIN mutation
    J Clin Immunol39, 138-141. PubMed  Europe PubMed DOI  M
29. Stangl,A., Elliott,P.R., Pinto-Fernandez,A., Bonham,S., Harrison,L., Schaub,A., Kutzner,K., Keusekotten,K., Pfluger,P.T., El Oualid,F., Kessler,B.M., Komander,D. and Krappmann,D.
    Regulation of the endosomal SNX27-retromer by OTULIN
    Nat Commun10, 4320-4320. PubMed  Europe PubMed DOI
2018
30. Heger,K., Wickliffe,K.E., Ndoja,A., Zhang,J., Murthy,A., Dugger,D.L., Maltzman,A., de Sousa E Melo,F., Hung,J., Zeng,Y., Verschueren,E., Kirkpatrick,D.S., Vucic,D., Lee,W.P., Roose-Girma,M., Newman,R.J., Warming,S., Hsiao,Y.C., Komuves,L.G., Webster,J.D., Newton,K. and Dixit,V.M.
    OTULIN limits cell death and inflammation by deubiquitinating LUBAC
    Nature559, 120-124. PubMed  Europe PubMed DOI
31. Su,Y., Shi,P., Zhang,L., Lu,D., Zhao,C., Li,R., Zhang,L. and Huang,J.
    The superimposed deubiquitination effect of OTULIN and PRRSV Nsp11 promoted the multiplication of PRRSV
    J Virol92, e00175-18-e00175-18. PubMed  Europe PubMed DOI
2017
32. Lork,M., Verhelst,K. and Beyaert,R.
    CYLD, A20 and OTULIN deubiquitinases in NF-kappaB signaling and cell death: so similar, yet so different
    Cell Death Differ24, 1172-1183. PubMed  Europe PubMed DOI
33. van Wijk,S.J.L., Fricke,F., Herhaus,L., Gupta,J., Hotte,K., Pampaloni,F., Grumati,P., Kaulich,M., Sou,Y.S., Komatsu,M., Greten,F.R., Fulda,S., Heilemann,M. and Dikic,I.
    Linear ubiquitination of cytosolic Salmonella typhimurium activates NF-kappaB and restricts bacterial proliferation
    Nat Microbiol2, 17066-17066. PubMed  Europe PubMed DOI
34. Weber,A., Elliott,P.R., Pinto-Fernandez,A., Bonham,S., Kessler,B.M., Komander,D., El Oualid,F. and Krappmann,D.
    A linear diubiquitin-based probe for efficient and selective detection of the deubiquitinating enzyme OTULIN
    Cell Chem Biol24, 1299-1313. PubMed  Europe PubMed DOI
2016
35. Damgaard,R.B., Walker,J.A., Marco-Casanova,P., Morgan,N.V., Titheradge,H.L., Elliott,P.R., McHale,D., Maher,E.R., McKenzie,A.N. and Komander,D.
    The deubiquitinase OTULIN is an essential negative regulator of inflammation and autoimmunity
    Cell166, 1215-1230. PubMed  Europe PubMed DOI  K
36. Elliott,P.R., Leske,D., Hrdinka,M., Bagola,K., Fiil,B.K., McLaughlin,S.H., Wagstaff,J., Volkmar,N., Christianson,J.C., Kessler,B.M., Freund,S.M., Komander,D. and Gyrd-Hansen,M.
    SPATA2 links CYLD to LUBAC, activates CYLD, and controls LUBAC signaling
    Mol Cell63, 990-1005. PubMed  Europe PubMed DOI
37. Elliott,P.R. and Komander,D.
    Regulation of Met1-linked polyubiquitin signalling by the deubiquitinase OTULIN
    FEBS J283, 39-53. PubMed  Europe PubMed DOI
38. Fiil,B.K. and Gyrd-Hansen,M.
    OTULIN deficiency causes auto-inflammatory syndrome
    Cell Res26, 1176-1177. PubMed  Europe PubMed DOI
39. Ronau,J.A., Beckmann,J.F. and Hochstrasser,M.
    Substrate specificity of the ubiquitin and Ubl proteases
    Cell Res26, 441-456. PubMed  Europe PubMed DOI
40. Zhou,Q., Yu,X., Demirkaya,E., Deuitch,N., Stone,D., Tsai,W.L., Kuehn,H.S., Wang,H., Yang,D., Park,Y.H., Ombrello,A.K., Blake,M., Romeo,T., Remmers,E.F., Chae,J.J., Mullikin,J.C., Guzel,F., Milner,J.D., Boehm,M., Rosenzweig,S.D., Gadina,M., Welch,S.B., Ozen,S., Topaloglu,R., Abinun,M., Kastner,D.L. and Aksentijevich,I.
    Biallelic hypomorphic mutations in a linear deubiquitinase define otulipenia, an early-onset autoinflammatory disease
    Proc Natl Acad Sci U S A113, 10127-10132. PubMed  Europe PubMed DOI  M
2014
41. Chen,Y., Wang,L., Cheng,X., Ge,X. and Wang,P.
    An ultrasensitive system for measuring the USPs and OTULIN activity using Nanoluc as a reporter
    Biochem Biophys Res Commun455, 178-183. PubMed  Europe PubMed DOI  A
42. Elliott,P.R., Nielsen,S.V., Marco-Casanova,P., Fiil,B.K., Keusekotten,K., Mailand,N., Freund,S.M., Gyrd-Hansen,M. and Komander,D.
    Molecular basis and regulation of OTULIN-LUBAC interaction
    Mol Cell54, 335-348. PubMed  Europe PubMed DOI  S
43. Schaeffer,V., Akutsu,M., Olma,M.H., Gomes,L.C., Kawasaki,M. and Dikic,I.
    Binding of OTULIN to the PUB domain of HOIP controls NF-kappaB signaling
    Mol Cell54, 349-361. PubMed  Europe PubMed DOI
44. Takiuchi,T., Nakagawa,T., Tamiya,H., Fujita,H., Sasaki,Y., Saeki,Y., Takeda,H., Sawasaki,T., Buchberger,A., Kimura,T. and Iwai,K.
    Suppression of LUBAC-mediated linear ubiquitination by a specific interaction between LUBAC and the deubiquitinases CYLD and OTULIN
    Genes Cells19, 254-272. PubMed  Europe PubMed DOI
2013
45. Keusekotten,K., Elliott,P.R., Glockner,L., Fiil,B.K., Damgaard,R.B., Kulathu,Y., Wauer,T., Hospenthal,M.K., Gyrd-Hansen,M., Krappmann,D., Hofmann,K. and Komander,D.
    OTULIN antagonizes LUBAC signaling by specifically hydrolyzing Met1-linked polyubiquitin
    Cell153, 1312-1326. PubMed  Europe PubMed DOI  S
46. Rivkin,E., Almeida,S.M., Ceccarelli,D.F., Juang,Y.C., Maclean,T.A., Srikumar,T., Huang,H., Dunham,W.H., Fukumura,R., Xie,G., Gondo,Y., Raught,B., Gingras,A.C., Sicheri,F. and Cordes,S.P.
    The linear ubiquitin-specific deubiquitinase gumby regulates angiogenesis
    Nature498, 318-324. PubMed  Europe PubMed DOI  M  S
47. Wiener,R. and Wolberger,C.
    A new DUB makes linear ubiquitin a party to its own destruction
    Cell153, 1189-1191. PubMed  Europe PubMed DOI