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Literature for C101.001

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

(Topics flags: S Structure, A Assay, M Mutation, K Knockout, P Specificity, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2026
  1. Chu,Y., Xu,Y., Huang,M., Fang,X., Huang,X., Yao,Z., Wu,J., Zhou,N., He,K., Liu,Y. and Wang,T.
    Linear ubiquitination of the NMDA receptor GluN2A subunit facilitates the GluN2B-to-GluN2A switch and synaptic maturation
    Proc Natl Acad Sci U S A (2026) 123, e2515389123-e2515389123. PubMed  Europe PubMed DOI  PMC  EPMC
    2. 2025
  2. Li,L., Li,M., Zhou,Y., Kakhniashvili,D., Wang,X. and Liao,F.F.
    OTULIN Interactome Reveals Immune Response and Autophagy Associated with Tauopathy in a Mouse Model
    bioRxiv (2025) PubMed  Europe PubMed DOI  PMC  EPMC
  3. Wang,Y., Liu,L., Zheng,Q., Wu,Y., Su,Z., Yuan,R., Xia,Q., Wang,B., Yu,Y. and Li,Y.M.
    Synergizing Structure-Guided Photocaged Linear Diubiquitin-Dha with Biotinylated Linear-Fab for Time-Resolved Profiling of Interactors in Living Cells
    J Am Chem Soc (2025) PubMed  Europe PubMed DOI
    4. 2024
  4. Caballero-Oteyza,A., Crisponi,L., Peng,X.P., Wang,H., Mrovecova,P., Olla,S., Siguri,C., Marnissi,F., Jouhadi,Z., Aksentijevich,I., Grimbacher,B. and Proietti,M.
    OTULIN-related conditions: Report of a new case and review of the literature using GenIA
    Clin Immunol (2024) 265, 110292-110292. PubMed  Europe PubMed DOI
  5. Caballero-Oteyza,A., Crisponi,L., Peng,X.P., Wang,H., Mrovecova,P., Olla,S., Siguri,C., Marnissi,F., Jouhadi,Z., Aksentijevich,I., Grimbacher,B. and Proietti,M.
    OTULIN-related conditions: Report of a new case and review of the literature using GenIA
    Res Sq (2024) PubMed  Europe PubMed DOI  PMC  EPMC
  6. Davidson,S., Shibata,Y., Collard,S., Zheng,H., Kong,K., Sun,J.M., Laohamonthonkul,P., Cerra,A., Kratina,T., Li,M.W.Y., Russell,C., van Beek,A., Kirk,E.P., Walsh,R., Alqanatish,J., Almojali,A., Alsuwairi,W., Alrasheed,A., Lalaoui,N., Gray,P.E., Komander,D. and Masters,S.L.
    Dominant negative OTULIN-related autoinflammatory syndrome
    J Exp Med (2024) 221 PubMed  Europe PubMed DOI  PMC  EPMC
  7. Wang,Q., Wang,L., Botchway,B.O.A., Zhang,Y., Huang,M. and Liu,X.
    OTULIN Can Improve Spinal Cord Injury by the NF-kappaB and Wnt/beta-Catenin Signaling Pathways
    Mol Neurobiol (2024) 61, 8820-8830. PubMed  Europe PubMed DOI  V
    8. 2023
  8. Almeida,S.M., Ivantsiv,S., Niibori,R., Dunham,W.H., Green,B.A., Zhao,L., Gingras,A.C. and Cordes,S.P.
    An interaction between OTULIN and SCRIB uncovers roles for linear ubiquitination in planar cell polarity
    Dis Model Mech (2023) 16 PubMed  Europe PubMed DOI  PMC  EPMC
    9. 2022
  9. Erol,A.
    Genotoxicity-Stimulated and CYLD-Driven Malignant Transformation
    Cancer Manag Res (2022) 14, 2339-2356. PubMed  Europe PubMed DOI  PMC  EPMC
  10. Li,M., Li,L., Asemota,S., Kakhniashvili,D., Narayanan,R., Wang,X. and Liao,F.F.
    Reciprocal interplay between OTULIN-LUBAC determines genotoxic and inflammatory NF-kappaB signal responses
    Proc Natl Acad Sci U S A (2022) 119, e2123097119-e2123097119. PubMed  Europe PubMed DOI  PMC  EPMC
  11. Spaan,A.N., Neehus,A.L., Laplantine,E., Staels,F., Ogishi,M., Seeleuthner,Y., Rapaport,F., Lacey,K.A., Van Nieuwenhove,E., Chrabieh,M., Hum,D., Migaud,M., Izmiryan,A., Lorenzo,L., Kochetkov,T., Heesterbeek,D.A.C., Bardoel,B.W., DuMont,A.L., Dobbs,K., Chardonnet,S., Heissel,S., Baslan,T., Zhang,P., Yang,R., Bogunovic,D., Wunderink,H.F., Haas,P.A., Molina,H., Van Buggenhout,G., Lyonnet,S., Notarangelo,L.D., Seppanen,M.R.J., Weil,R., Seminario,G., Gomez-Tello,H., Wouters,C., Mesdaghi,M., Shahrooei,M., Bossuyt,X., Sag,E., Topaloglu,R., Ozen,S., Leavis,H.L., van Eijk,M.M.J., Bezrodnik,L., Blancas Galicia,L., Hovnanian,A., Nassif,A., Bader-Meunier,B., Neven,B., Meyts,I., Schrijvers,R., Puel,A., Bustamante,J., Aksentijevich,I., Kastner,D.L., Torres,V.J., Humblet-Baron,S., Liston,A., Abel,L., Boisson,B. and Casanova,J.L.
    Human OTULIN haploinsufficiency impairs cell-intrinsic immunity to staphylococcal alpha-toxin
    Science (2022) 376, eabm6380-eabm6380. PubMed  Europe PubMed DOI  PMC  EPMC
    12. 2021
  12. Fu,Y., Wang,H., Dai,H., Zhu,Q., Cui,C.P., Sun,X., Li,Y., Deng,Z., Zhou,X., Ge,Y., Peng,Z., Yuan,C., Wu,B., Yang,X., Li,R., Liu,C.H., He,F., Wei,W. and Zhang,L.
    OTULIN allies with LUBAC to govern angiogenesis by editing ALK1 linear polyubiquitin
    Mol Cell (2021) PubMed  Europe PubMed DOI
  13. Hoste,E., Lecomte,K., Annusver,K., Vandamme,N., Roels,J., Maschalidi,S., Verboom,L., Vikkula,H.K., Sze,M., Van Hove,L., Verstaen,K., Martens,A., Hochepied,T., Saeys,Y., Ravichandran,K., Kasper,M. and Van Loo,G.
    OTULIN maintains skin homeostasis by controlling keratinocyte death and stem cell identity
    Nat Commun (2021) 12, 5913-5913. PubMed  Europe PubMed DOI  PMC  EPMC
  14. Raja,R. and Sen,G.C.
    The antiviral action of the RIG-I induced pathway of apoptosis (RIPA) is enhanced by its ability to degrade Otulin, which deubiquitinates IRF3
    Cell Death Differ (2021) PubMed  Europe PubMed DOI
  15. Schunke,H., Gobel,U., Dikic,I. and Pasparakis,M.
    OTULIN inhibits RIPK1-mediated keratinocyte necroptosis to prevent skin inflammation in mice
    Nat Commun (2021) 12, 5912-5912. PubMed  Europe PubMed DOI  PMC  EPMC
  16. Shi,R., Shi,X., Qin,D., Tang,S., Vermeulen,M. and Zhang,X.
    SNX27-driven membrane localisation of OTULIN antagonises linear ubiquitination and NF-kappaB signalling activation
    Cell Biosci (2021) 11, 146-146. PubMed  Europe PubMed DOI  PMC  EPMC
  17. Snyder,N.A. and Silva,G.M.
    Deubiquitinating enzymes (DUBs): Regulation, homeostasis, and oxidative stress response
    J Biol Chem (2021) 297, 101077-101077. PubMed  Europe PubMed DOI  V
  18. ten Dijke,P. and Baker,D.
    Fine-tuning ALK1 linear polyubiquitination to control angiogenesis
    Trends Cell Biol (2021) 31, 705-707. PubMed  Europe PubMed DOI
  19. Verboom,L., Hoste,E. and Van Loo,G.
    OTULIN in NF-kappaB signaling, cell death, and disease
    Trends Immunol (2021) 42, 590-603. PubMed  Europe PubMed DOI  V
  20. Weinelt,N. and van Wijk,S.J.L.
    Ubiquitin-dependent and -independent functions of OTULIN in cell fate control and beyond
    Cell Death Differ (2021) 28, 493-504. PubMed  Europe PubMed DOI
  21. Xu,H., Wang,Y. and Luo,Y.
    OTULIN is a new target of EA treatment in the alleviation of brain injury and glial cell activation via suppression of the NF-kappaB signalling pathway in acute ischaemic stroke rats
    Mol Med (2021) 27, 37-37. PubMed  Europe PubMed DOI  PMC  EPMC
    22. 2020
  22. Chu,Y., Kang,Y., Yan,C., Yang,C., Zhang,T., Huo,H. and Liu,Y.
    LUBAC and OTULIN regulate autophagy initiation and maturation by mediating the linear ubiquitination and the stabilization of ATG13
    Autophagy (2020) , 1-16. PubMed  Europe PubMed DOI
  23. Damgaard,R.B., Jolin,H.E., Allison,M.E.D., Davies,S.E., Titheradge,H.L., McKenzie,A.N.J. and Komander,D.
    OTULIN protects the liver against cell death, inflammation, fibrosis, and cancer
    Cell Death Differ (2020) 27, 1457-1474. PubMed  Europe PubMed DOI
  24. Douglas,T. and Saleh,M.
    The plot thickens: OTULIN regulation in cell death
    Mol Cell Oncol (2020) 7, 1740541-1740541. PubMed  Europe PubMed DOI  PMC  EPMC
  25. Oikawa,D., Hatanaka,N., Suzuki,T. and Tokunaga,F.
    Cellular and Mathematical Analyses of LUBAC Involvement in T Cell Receptor-Mediated NF-kappaB Activation Pathway
    Front Immunol (2020) 11, 601926-601926. PubMed  Europe PubMed DOI  PMC  EPMC
  26. Verboom,L., Martens,A., Priem,D., Hoste,E., Sze,M., Vikkula,H., Van Hove,L., Voet,S., Roels,J., Maelfait,J., Bongiovanni,L., de Bruin,A., Scott,C.L., Saeys,Y., Pasparakis,M., Bertrand,M.J.M. and Van Loo,G.
    OTULIN Prevents liver inflammation and hepatocellular carcinoma by inhibiting FADD- and RIPK1 kinase-mediated hepatocyte apoptosis
    Cell Rep (2020) 30, 2237-2247. PubMed  Europe PubMed DOI
  27. Wang,W., Li,M., Ponnusamy,S., Chi,Y., Xue,J., Fahmy,B., Fan,M., Miranda-Carboni,G.A., Narayanan,R., Wu,J. and Wu,Z.H.
    ABL1-dependent OTULIN phosphorylation promotes genotoxic Wnt/beta-catenin activation to enhance drug resistance in breast cancers
    Nat Commun (2020) 11, 3965-3965. PubMed  Europe PubMed DOI  PMC  EPMC
  28. Wang,W. and Wu,Z.H.
    OTULIN couples WNT signaling to resistance in triple-negative breast cancer
    Mol Cell Oncol (2020) 7, 1825904-1825904. PubMed  Europe PubMed DOI  PMC  EPMC
    29. 2019
  29. Douglas,T. and Saleh,M.
    Post-translational modification of OTULIN regulates ubiquitin dynamics and cell death
    Cell Rep (2019) 29, 3652-3663. PubMed  Europe PubMed DOI  P
  30. Nabavi,M., Shahrooei,M., Rokni-Zadeh,H., Vrancken,J., Changi-Ashtiani,M., Darabi,K., Manian,M., Seif,F., Meyts,I., Voet,A., Moens,L. and Bossuyt,X.
    Auto-inflammation in a patient with a novel homozygous OTULIN mutation
    J Clin Immunol (2019) 39, 138-141. PubMed  Europe PubMed DOI  M
  31. Stangl,A., Elliott,P.R., Pinto-Fernandez,A., Bonham,S., Harrison,L., Schaub,A., Kutzner,K., Keusekotten,K., Pfluger,P.T., El Oualid,F., Kessler,B.M., Komander,D. and Krappmann,D.
    Regulation of the endosomal SNX27-retromer by OTULIN
    Nat Commun (2019) 10, 4320-4320. PubMed  Europe PubMed DOI  PMC  EPMC
    32. 2018
  32. Heger,K., Wickliffe,K.E., Ndoja,A., Zhang,J., Murthy,A., Dugger,D.L., Maltzman,A., de Sousa E Melo,F., Hung,J., Zeng,Y., Verschueren,E., Kirkpatrick,D.S., Vucic,D., Lee,W.P., Roose-Girma,M., Newman,R.J., Warming,S., Hsiao,Y.C., Komuves,L.G., Webster,J.D., Newton,K. and Dixit,V.M.
    OTULIN limits cell death and inflammation by deubiquitinating LUBAC
    Nature (2018) 559, 120-124. PubMed  Europe PubMed DOI
  33. Su,Y., Shi,P., Zhang,L., Lu,D., Zhao,C., Li,R., Zhang,L. and Huang,J.
    The superimposed deubiquitination effect of OTULIN and PRRSV Nsp11 promoted the multiplication of PRRSV
    J Virol (2018) 92, e00175-18-e00175-18. PubMed  Europe PubMed DOI
    34. 2017
  34. Lork,M., Verhelst,K. and Beyaert,R.
    CYLD, A20 and OTULIN deubiquitinases in NF-kappaB signaling and cell death: so similar, yet so different
    Cell Death Differ (2017) 24, 1172-1183. PubMed  Europe PubMed DOI
  35. van Wijk,S.J.L., Fricke,F., Herhaus,L., Gupta,J., Hotte,K., Pampaloni,F., Grumati,P., Kaulich,M., Sou,Y.S., Komatsu,M., Greten,F.R., Fulda,S., Heilemann,M. and Dikic,I.
    Linear ubiquitination of cytosolic Salmonella typhimurium activates NF-kappaB and restricts bacterial proliferation
    Nat Microbiol (2017) 2, 17066-17066. PubMed  Europe PubMed DOI
  36. Weber,A., Elliott,P.R., Pinto-Fernandez,A., Bonham,S., Kessler,B.M., Komander,D., El Oualid,F. and Krappmann,D.
    A linear diubiquitin-based probe for efficient and selective detection of the deubiquitinating enzyme OTULIN
    Cell Chem Biol (2017) 24, 1299-1313. PubMed  Europe PubMed DOI  PMC  EPMC
    37. 2016
  37. Damgaard,R.B., Walker,J.A., Marco-Casanova,P., Morgan,N.V., Titheradge,H.L., Elliott,P.R., McHale,D., Maher,E.R., McKenzie,A.N. and Komander,D.
    The deubiquitinase OTULIN is an essential negative regulator of inflammation and autoimmunity
    Cell (2016) 166, 1215-1230. PubMed  Europe PubMed DOI  K
  38. Elliott,P.R. and Komander,D.
    Regulation of Met1-linked polyubiquitin signalling by the deubiquitinase OTULIN
    FEBS J (2016) 283, 39-53. PubMed  Europe PubMed DOI
  39. Elliott,P.R., Leske,D., Hrdinka,M., Bagola,K., Fiil,B.K., McLaughlin,S.H., Wagstaff,J., Volkmar,N., Christianson,J.C., Kessler,B.M., Freund,S.M., Komander,D. and Gyrd-Hansen,M.
    SPATA2 links CYLD to LUBAC, activates CYLD, and controls LUBAC signaling
    Mol Cell (2016) 63, 990-1005. PubMed  Europe PubMed DOI
  40. Fiil,B.K. and Gyrd-Hansen,M.
    OTULIN deficiency causes auto-inflammatory syndrome
    Cell Res (2016) 26, 1176-1177. PubMed  Europe PubMed DOI
  41. Ronau,J.A., Beckmann,J.F. and Hochstrasser,M.
    Substrate specificity of the ubiquitin and Ubl proteases
    Cell Res (2016) 26, 441-456. PubMed  Europe PubMed DOI
  42. Zhou,Q., Yu,X., Demirkaya,E., Deuitch,N., Stone,D., Tsai,W.L., Kuehn,H.S., Wang,H., Yang,D., Park,Y.H., Ombrello,A.K., Blake,M., Romeo,T., Remmers,E.F., Chae,J.J., Mullikin,J.C., Guzel,F., Milner,J.D., Boehm,M., Rosenzweig,S.D., Gadina,M., Welch,S.B., Ozen,S., Topaloglu,R., Abinun,M., Kastner,D.L. and Aksentijevich,I.
    Biallelic hypomorphic mutations in a linear deubiquitinase define otulipenia, an early-onset autoinflammatory disease
    Proc Natl Acad Sci U S A (2016) 113, 10127-10132. PubMed  Europe PubMed DOI  M
    43. 2014
  43. Chen,Y., Wang,L., Cheng,X., Ge,X. and Wang,P.
    An ultrasensitive system for measuring the USPs and OTULIN activity using Nanoluc as a reporter
    Biochem Biophys Res Commun (2014) 455, 178-183. PubMed  Europe PubMed DOI  A
  44. Elliott,P.R., Nielsen,S.V., Marco-Casanova,P., Fiil,B.K., Keusekotten,K., Mailand,N., Freund,S.M., Gyrd-Hansen,M. and Komander,D.
    Molecular basis and regulation of OTULIN-LUBAC interaction
    Mol Cell (2014) 54, 335-348. PubMed  Europe PubMed DOI  S
  45. Schaeffer,V., Akutsu,M., Olma,M.H., Gomes,L.C., Kawasaki,M. and Dikic,I.
    Binding of OTULIN to the PUB domain of HOIP controls NF-kappaB signaling
    Mol Cell (2014) 54, 349-361. PubMed  Europe PubMed DOI
  46. Takiuchi,T., Nakagawa,T., Tamiya,H., Fujita,H., Sasaki,Y., Saeki,Y., Takeda,H., Sawasaki,T., Buchberger,A., Kimura,T. and Iwai,K.
    Suppression of LUBAC-mediated linear ubiquitination by a specific interaction between LUBAC and the deubiquitinases CYLD and OTULIN
    Genes Cells (2014) 19, 254-272. PubMed  Europe PubMed DOI
    47. 2013
  47. Keusekotten,K., Elliott,P.R., Glockner,L., Fiil,B.K., Damgaard,R.B., Kulathu,Y., Wauer,T., Hospenthal,M.K., Gyrd-Hansen,M., Krappmann,D., Hofmann,K. and Komander,D.
    OTULIN antagonizes LUBAC signaling by specifically hydrolyzing Met1-linked polyubiquitin
    Cell (2013) 153, 1312-1326. PubMed  Europe PubMed DOI  S
  48. Rivkin,E., Almeida,S.M., Ceccarelli,D.F., Juang,Y.C., Maclean,T.A., Srikumar,T., Huang,H., Dunham,W.H., Fukumura,R., Xie,G., Gondo,Y., Raught,B., Gingras,A.C., Sicheri,F. and Cordes,S.P.
    The linear ubiquitin-specific deubiquitinase gumby regulates angiogenesis
    Nature (2013) 498, 318-324. PubMed  Europe PubMed DOI  M  S
  49. Wiener,R. and Wolberger,C.
    A new DUB makes linear ubiquitin a party to its own destruction
    Cell (2013) 153, 1189-1191. PubMed  Europe PubMed DOI

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