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Literature for peptidase C10.001: streptopain

Summary Alignment Sequences Sequence features Distribution Structure Literature Substrates

(Topics flags: A Assay, S Structure, P Specificity, I Inhibitor, E Expression, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Vassen,V., Tanaka,E., Moll,K., Spoerry,C., Synowsky,S., Shirran,S.L., Schwarz-Linek,U., Loh,E., Svensson,M. and Norrby-Teglund,A.
    Group A streptococcal SpeB modifies IgA through targeting regions other than the hinge
    Microbiol Spectr (2025) , e0245024-e0245024. PubMed  Europe PubMed DOI
    2. 2024
  2. Zhu,B., Lane,M.D., Baller,J.A., Jagtap,P.D., Griffin,T.J. and Seelig,B.
    Comprehensive protease specificity profiling
    bioRxiv (2024) PubMed  Europe PubMed DOI  PMC  EPMC
    3. 2023
  3. Chiang-Ni,C., Chiang,C.Y., Chen,Y.W., Shi,Y.A., Chao,Y.T., Wang,S., Tsai,P.J. and Chiu,C.H.
    RopB-regulated SpeB cysteine protease degrades extracellular vesicles-associated streptolysin O and bacterial proteins from group A Streptococcus
    Virulence (2023) 14, 2249784-2249784. PubMed  Europe PubMed DOI  PMC  EPMC
    4. 2022
  4. Deng,W., Bai,Y., Deng,F., Pan,Y., Mei,S., Zheng,Z., Min,R., Wu,Z., Li,W., Miao,R., Zhang,Z., Kupper,T.S., Lieberman,J. and Liu,X.
    Streptococcal pyrogenic exotoxin B cleaves GSDMA and triggers pyroptosis
    Nature (2022) 602, 496-502. PubMed  Europe PubMed DOI
  5. LaRock,D.L., Johnson,A.F., Wilde,S., Sands,J.S., Monteiro,M.P. and LaRock,C.N.
    Group A Streptococcus induces GSDMA-dependent pyroptosis in keratinocytes
    Nature (2022) 605, 527-531. PubMed  Europe PubMed DOI  PMC  EPMC
    6. 2020
  6. Woehl,J.L., Kitamura,S., Dillon,N., Han,Z., Edgar,L.J., Nizet,V. and Wolan,D.W.
    An Irreversible Inhibitor to Probe the Role of Streptococcus pyogenes Cysteine Protease SpeB in Evasion of Host Complement Defenses
    ACS Chem Biol (2020) 15, 2060-2069. PubMed  Europe PubMed DOI  I
    7. 2018
  7. Brouwer,S., Cork,A.J., Ong,C.Y., Barnett,T.C., West,N.P., McIver,K.S. and Walker,M.J.
    The endopeptidase PepO regulates the SpeB cysteine protease and is essential for the virulence of invasive M1T1 Streptococcus pyogenes
    J Bacteriol (2018) 200, e00654-17-e00654-17. PubMed  Europe PubMed DOI
  8. Sumitomo,T., Mori,Y., Nakamura,Y., Honda-Ogawa,M., Nakagawa,S., Yamaguchi,M., Matsue,H., Terao,Y., Nakata,M. and Kawabata,S.
    Streptococcal cysteine protease-mediated cleavage of desmogleins is involved in the pathogenesis of cutaneous infection
    Front Cell Infect Microbiol (2018) 8, 10-10. PubMed  Europe PubMed DOI  PMC  EPMC
    9. 2017
  9. Do,H., Makthal,N., VanderWal,A.R., Rettel,M., Savitski,M.M., Peschek,N., Papenfort,K., Olsen,R.J., Musser,J.M. and Kumaraswami,M.
    Leaderless secreted peptide signaling molecule alters global gene expression and increases virulence of a human bacterial pathogen
    Proc Natl Acad Sci U S A (2017) 114, E8498-E8498. PubMed  Europe PubMed DOI
  10. Sjogren,J., Andersson,L., Mejare,M. and Olsson,F.
    Generating and purifying Fab fragments from human and mouse IgG using the bacterial enzymes IdeS, SpeB and Kgp
    Methods Mol Biol (2017) 1535, 319-329. PubMed  Europe PubMed DOI
    11. 2016
  11. Arzanlou,M.
    Inhibition of streptococcal pyrogenic exotoxin B using allicin from garlic
    Microb Pathog (2016) 93, 166-171. PubMed  Europe PubMed DOI  I
  12. Lane,M.D. and Seelig,B.
    Highly efficient recombinant production and purification of streptococcal cysteine protease streptopain with increased enzymatic activity
    Protein Expr Purif (2016) 121, 66-72. PubMed  Europe PubMed DOI  E
  13. Zhang,Z., Perrault,R., Zhao,Y. and Ding,J.
    SpeB proteolysis with imaged capillary isoelectric focusing for the characterization of domain-specific charge heterogeneities of reference and biosimilar Rituximab
    J Chromatogr B Analyt Technol Biomed Life Sci (2016) 1020, 148-157. PubMed  Europe PubMed DOI
    14. 2015
  14. Olsen,R.J., Raghuram,A., Cantu,C., Hartman,M.H., Jimenez,F.E., Lee,S., Ngo,A., Rice,K.A., Saddington,D., Spillman,H., Valson,C., Flores,A.R., Beres,S.B., Long,S.W., Nasser,W. and Musser,J.M.
    The majority of 9,729 group A streptococcus strains causing disease secrete SpeB cysteine protease: pathogenesis implications
    Infect Immun (2015) 83, 4750-4758. PubMed  Europe PubMed DOI
  15. Wang,A.Y., Gonzalez-Paez,G.E. and Wolan,D.W.
    Identification and co-complex structure of a new S. pyogenes SpeB small molecule inhibitor
    Biochemistry (2015) 54, 4365-4373. PubMed  Europe PubMed DOI  S  I
    16. 2014
  16. Chella Krishnan,K., Mukundan,S., Landero Figueroa,J.A., Caruso,J.A. and Kotb,M.
    Metal-mediated modulation of Streptococcal cysteine protease activity and its biological implications
    Infect Immun (2014) 82, 2992-3001. PubMed  Europe PubMed DOI
    17. 2013
  17. Ender,M., Andreoni,F., Zinkernagel,A.S. and Schuepbach,R.A.
    Streptococcal SpeB cleaved PAR-1 suppresses ERK phosphorylation and blunts thrombin-induced platelet aggregation
    PLoS ONE (2013) 8, e81298-e81298. PubMed  Europe PubMed DOI  PMC  EPMC
  18. Honda-Ogawa,M., Ogawa,T., Terao,Y., Sumitomo,T., Nakata,M., Ikebe,K., Maeda,Y. and Kawabata,S.
    Cysteine proteinase from Streptococcus pyogenes enables evasion of innate immunity via degradation of complement factors
    J Biol Chem (2013) 288, 15854-15864. PubMed  Europe PubMed DOI
  19. Nakagawa,I.
    Streptococcus pyogenes escapes from autophagy
    Cell Host Microbe (2013) 14, 604-606. PubMed  Europe PubMed DOI
  20. Persson,H., Vindebro,R. and von Pawel-Rammingen,U.
    The streptococcal cysteine protease SpeB is not a natural immunoglobulin-cleaving enzyme
    Infect Immun (2013) 81, 2236-2241. PubMed  Europe PubMed DOI
  21. Sumitomo,T., Nakata,M., Higashino,M., Terao,Y. and Kawabata,S.
    Group A streptococcal cysteine protease cleaves epithelial junctions and contributes to bacterial translocation
    J Biol Chem (2013) 288, 13317-13324. PubMed  Europe PubMed DOI
    22. 2012
  22. Chiang-Ni,C., Zheng,P.X., Tsai,P.J., Chuang,W.J., Lin,Y.S., Liu,C.C. and Wu,J.J.
    Environmental pH changes, but not the LuxS signalling pathway, regulate SpeB expression in M1 group A streptococci
    J Med Microbiol (2012) 61, 16-22. PubMed  Europe PubMed DOI
  23. Chuang,W.J., Lin,Y.S., Wu,J.J., Liu,C.C. and Lin,M.T.
    Streptopain
    [ISSN:978-0-12-407743-0] (2012) 3, 2142-2150. DOI
  24. Gonzalez-Paez,G.E. and Wolan,D.W.
    Ultrahigh and high resolution structures and mutational analysis of monomeric Streptococcus pyogenes SpeB reveal a functional role for the glycine-rich C-terminal loop
    J Biol Chem (2012) 287, 24412-24426. PubMed  Europe PubMed DOI  A  S  I
  25. Minami,M., Ichikawa,M., Ohta,M. and Hasegawa,T.
    The cell envelope-associated protein, LytR, regulates the cysteine protease SpeB in Streptococcus pyogenes
    APMIS (2012) 120, 417-426. PubMed  Europe PubMed DOI
  26. Olsen,R.J., Laucirica,D.R., Watkins,M.E., Feske,M.L., Garcia-Bustillos,J.R., Vu,C., Cantu,C., Shelburne,S.A., III, Fittipaldi,N., Kumaraswami,M., Shea,P.R., Flores,A.R., Beres,S.B., Lovgren,M., Tyrrell,G.J., Efstratiou,A., Low,D.E., Van Beneden,C.A. and Musser,J.M.
    Polymorphisms in regulator of protease B (RopB) alter disease phenotype and strain virulence of serotype M3 group A Streptococcus
    J Infect Dis (2012) 205, 1719-1729. PubMed  Europe PubMed DOI
    27. 2011
  27. Carroll,R.K. and Musser,J.M.
    From transcription to activation: how group A streptococcus, the flesh-eating pathogen, regulates SpeB cysteine protease production
    Mol Microbiol (2011) 81, 588-601. PubMed  Europe PubMed DOI
  28. Connolly,K.L., Roberts,A.L., Holder,R.C. and Reid,S.D.
    Dispersal of Group A streptococcal biofilms by the cysteine protease SpeB leads to increased disease severity in a murine model
    PLoS ONE (2011) 6, e18984-e18984. PubMed  Europe PubMed DOI  PMC  EPMC
  29. Meinert Niclasen,L., Olsen,J.G., Dagil,R., Qing,Z., Sorensen,O.E. and Kragelund,B.B.
    Streptococcal pyogenic exotoxin B (SpeB) boosts the contact system via binding of alpha-1 antitrypsin
    Biochem J (2011) 434, 123-132. PubMed  Europe PubMed DOI
  30. Nelson,D.C., Garbe,J. and Collin,M.
    Cysteine proteinase SpeB from Streptococcus pyogenes - a potent modifier of immunologically important host and bacterial proteins
    Biol Chem (2011) 392, 1077-1088. PubMed  Europe PubMed DOI  V
    31. 2010
  31. Luo,Y.H., Chuang,W.J., Wu,J.J., Lin,M.T., Liu,C.C., Lin,P.Y., Roan,J.N., Wong,T.W., Chen,Y.L. and Lin,Y.S.
    Molecular mimicry between streptococcal pyrogenic exotoxin B and endothelial cells
    Lab Invest (2010) 90, 1492-1506. PubMed  Europe PubMed DOI
  32. Olsen,R.J., Sitkiewicz,I., Ayeras,A.A., Gonulal,V.E., Cantu,C., Beres,S.B., Green,N.M., Lei,B., Humbird,T., Greaver,J., Chang,E., Ragasa,W.P., Montgomery,C.A., Cartwright,J., Jr., McGeer,A., Low,D.E., Whitney,A.R., Cagle,P.T., Blasdel,T.L., DeLeo,F.R. and Musser,J.M.
    Decreased necrotizing fasciitis capacity caused by a single nucleotide mutation that alters a multiple gene virulence axis
    Proc Natl Acad Sci U S A (2010) 107, 888-893. PubMed  Europe PubMed DOI
  33. Roberts,A.L., Holder,R.C. and Reid,S.D.
    Allelic replacement of the streptococcal cysteine protease SpeB in a deltasrv mutant background restores biofilm formation
    BMC Res Notes (2010) 3, 281-281. PubMed  Europe PubMed DOI
    34. 2009
  34. Doern,C.D., Roberts,A.L., Hong,W., Nelson,J., Lukomski,S., Swords,W.E. and Reid,S.D.
    Biofilm formation by group A Streptococcus: a role for the streptococcal regulator of virulence (Srv) and streptococcal cysteine protease (SpeB)
    Microbiology (Reading) (2009) 155, 46-52. PubMed  Europe PubMed DOI  PMC  EPMC
  35. Ma,Y., Bryant,A.E., Salmi,D.B., McIndoo,E. and Stevens,D.L.
    vfr, a novel locus affecting cysteine protease production in Streptococcus pyogenes
    J Bacteriol (2009) 191, 3189-3194. PubMed  Europe PubMed DOI  PMC  EPMC
  36. Olsen,J.G., Dagil,R., Niclasen,L.M., Sorensen,O.E. and Kragelund,B.B.
    Structure of the mature streptococcal cysteine protease exotoxin mSpeB in its active dimeric form
    J Mol Biol (2009) 393, 693-703. PubMed  Europe PubMed DOI  S
  37. Wang,C.C., Houng,H.C., Chen,C.L., Wang,P.J., Kuo,C.F., Lin,Y.S., Wu,J.J., Lin,M.T., Liu,C.C., Huang,W. and Chuang,W.J.
    Solution structure and backbone dynamics of streptopain: insight into diverse substrate specificity
    J Biol Chem (2009) 284, 10957-10967. PubMed  Europe PubMed DOI  PMC  EPMC  S
    38. 2008
  38. Allhorn,M., Olsen,A. and Collin,M.
    EndoS from Streptococcus pyogenes is hydrolyzed by the cysteine proteinase SpeB and requires glutamic acid 235 and tryptophans for IgG glycan-hydrolyzing activity
    BMC Microbiol (2008) 8, 3-3. PubMed  Europe PubMed DOI  PMC  EPMC
  39. Chiang-Ni,C. and Wu,J.J.
    Effects of streptococcal pyrogenic exotoxin B on pathogenesis of Streptococcus pyogenes
    J Formos Med Assoc (2008) 107, 677-685. PubMed  Europe PubMed DOI  V
  40. Hollands,A., Aziz,R.K., Kansal,R., Kotb,M., Nizet,V. and Walker,M.J.
    A naturally occurring mutation in ropB suppresses SpeB expression and reduces M1T1 group A streptococcal systemic virulence
    PLoS ONE (2008) 3, e4102-e4102. PubMed  Europe PubMed DOI  PMC  EPMC
  41. Hsu,J.F., Chuang,W.J., Shiesh,S.C., Lin,Y.S., Liu,C.C., Wang,C.C., Fu,T.F., Tsai,J.H., Tsai,W.L., Huang,Y.J., Hsieh,Y.H., Wu,J.J., Lin,M.T. and Huang,W.
    Streptococcal pyrogenic exotoxin B cleaves human S-adenosylhomocysteine hydrolase and induces hypermethioninemia
    J Infect Dis (2008) 198, 367-374. PubMed  Europe PubMed DOI
  42. Johansson,L., Thulin,P., Sendi,P., Hertzen,E., Linder,A., Akesson,P., Low,D.E., Agerberth,B. and Norrby-Teglund,A.
    Cathelicidin LL-37 in severe Streptococcus pyogenes soft tissue infections in humans
    Infect Immun (2008) 76, 3399-3404. PubMed  Europe PubMed DOI  PMC  EPMC
  43. Kuo,C.F., Lin,Y.S., Chuang,W.J., Wu,J.J. and Tsao,N.
    Degradation of complement 3 by streptococcal pyrogenic exotoxin B inhibits complement activation and neutrophil opsonophagocytosis
    Infect Immun (2008) 76, 1163-1169. PubMed  Europe PubMed DOI  PMC  EPMC
  44. Terao,Y., Mori,Y., Yamaguchi,M., Shimizu,Y., Ooe,K., Hamada,S. and Kawabata,S.
    Group A streptococcal cysteine protease degrades C3 (C3b) and contributes to evasion of innate immunity
    J Biol Chem (2008) 283, 6253-6260. PubMed  Europe PubMed DOI
  45. Ulrich,R.G.
    Vaccine based on a ubiquitous cysteinyl protease and streptococcal pyrogenic exotoxin A protects against Streptococcus pyogenes sepsis and toxic shock
    J Immune Based Ther Vaccines (2008) 6, 8-8. PubMed  Europe PubMed DOI  PMC  EPMC
    46. 2007
  46. Cole,J.N., Aquilina,J.A., Hains,P.G., Henningham,A., Sriprakash,K.S., Caparon,M.G., Nizet,V., Kotb,M., Cordwell,S.J., Djordjevic,S.P. and Walker,M.J.
    Role of group A Streptococcus HtrA in the maturation of SpeB protease
    Proteomics (2007) 7, 4488-4498. PubMed  Europe PubMed DOI
    47. 2006
  47. [YEAR:21-6-2006]Cole,J.N., McArthur,J.D., McKay,F.C., Sanderson-Smith,M.L., Cork,A.J., Ranson,M., Rohde,M., Itzek,A., Sun,H., Ginsburg,D., Kotb,M., Nizet,V., Chhatwal,G.S. and Walker,M.J.
    Trigger for group A streptococcal M1T1 invasive disease
    FASEB J (21-6-2006) 20, 1745-1747. PubMed  Europe PubMed DOI
  48. Loughman,J.A. and Caparon,M.
    Regulation of SpeB in Streptococcus pyogenes by pH and NaCl: a model for in vivo gene expression
    J Bacteriol (2006) 188, 399-408. PubMed  Europe PubMed DOI  PMC  EPMC
  49. [YEAR:15-9-2006]Nooh,M.M., Aziz,R.K., Kotb,M., Eroshkin,A., Chuang,W.J., Proft,T. and Kansal,R.
    Streptococcal mitogenic exotoxin, SmeZ, is the most susceptible M1T1 streptococcal superantigen to degradation by the streptococcal cysteine protease, SpeB
    J Biol Chem (15-9-2006) 281, 35281-35288. PubMed  Europe PubMed DOI
  50. [YEAR:20-1-2006]Tsao,N., Tsai,W.H., Lin,Y.S., Chuang,W.J., Wang,C.H. and Kuo,C.F.
    Streptococcal pyrogenic exotoxin B cleaves properdin and inhibits complement-mediated opsonophagocytosis
    Biochem Biophys Res Commun (20-1-2006) 339, 779-784. PubMed  Europe PubMed DOI
    51. 2005
  51. [YEAR:15-4-2005]Anderson,E.T., Winter,L.A., Fernsten,P., Olmsted,S.B. and Matsuka,Y.V.
    The pro-sequence domain of streptopain directs the folding of the mature enzyme
    Arch Biochem Biophys (15-4-2005) 436, 297-306. PubMed  Europe PubMed DOI
  52. Kagawa,T.F., O'Toole,P.W. and Cooney,J.C.
    SpeB-Spi: a novel protease-inhibitor pair from Streptococcus pyogenes
    Mol Microbiol (2005) 57, 650-666. PubMed  Europe PubMed DOI
  53. Rosch,J.W. and Caparon,M.G.
    The ExPortal: an organelle dedicated to the biogenesis of secreted proteins in Streptococcus pyogenes
    Mol Microbiol (2005) 58, 959-968. PubMed  Europe PubMed DOI
  54. Wei,L., Pandiripally,V., Gregory,E., Clymer,M. and Cue,D.
    Impact of the SpeB protease on binding of the complement regulatory proteins factor H and factor H-like protein 1 by Streptococcus pyogenes
    Infect Immun (2005) 73, 2040-2050. PubMed  Europe PubMed DOI  PMC  EPMC
  55. Zimmerlein,B., Park,H.S., Li,S., Podbielski,A. and Cleary,P.P.
    The M protein is dispensable for maturation of streptococcal cysteine protease SpeB
    Infect Immun (2005) 73, 859-864. PubMed  Europe PubMed DOI  PMC  EPMC
    56. 2004
  56. Aziz,R.K., Pabst,M.J., Jeng,A., Kansal,R., Low,D.E., Nizet,V. and Kotb,M.
    Invasive M1T1 group A Streptococcus undergoes a phase-shift in vivo to prevent proteolytic degradation of multiple virulence factors by SpeB
    Mol Microbiol (2004) 51, 123-134. PubMed  Europe PubMed DOI
  57. Kuo,C.F., Luo,Y.H., Lin,H.Y., Huang,K.J., Wu,J.J., Lei,H.Y., Lin,M.T., Chuang,W.J., Liu,C.C., Jin,Y.T. and Lin,Y.S.
    Histopathologic changes in kidney and liver correlate with streptococcal pyrogenic exotoxin B production in the mouse model of group A streptococcal infection
    Microb Pathog (2004) 36, 273-285. PubMed  Europe PubMed DOI
  58. Lyon,W.R. and Caparon,M.G.
    Role for serine protease HtrA (DegP) of Streptococcus pyogenes in the biogenesis of virulence factors SpeB and the hemolysin streptolysin S
    Infect Immun (2004) 72, 1618-1625. PubMed  Europe PubMed DOI  PMC  EPMC
  59. Nyberg,P., Rasmussen,M., von Pawel-Rammingen,U. and Bjorck,L.
    SpeB modulates fibronectin-dependent internalization of Streptococcus pyogenes by efficient proteolysis of cell-wall-anchored protein F1
    Microbiology (Reading, Engl.) (2004) 150, 1559-1569. PubMed  Europe PubMed
  60. Ohkuni,H., Todome,Y., Watanabe,Y., Ishikaw,T., Takahashi,H., Kannari,Y., Kato,H., Uchiyama,T., Saito,H., Fischetti,V.A. and Zabriskie,J.B.
    Studies of recombinant streptococcal pyrogenic exotoxin B/cysteine protease (rSPE B/SCP) in the skin of guinea pigs & the release of histamine from cultured mast cells & basophilic leukocytes
    Indian J Med Res (2004) 119 Suppl, 33-36. PubMed  Europe PubMed
  61. Tamura,F., Nakagawa,R., Akuta,T., Okamoto,S., Hamada,S., Maeda,H., Kawabata,S. and Akaike,T.
    Proapoptotic effect of proteolytic activation of matrix metalloproteinases by Streptococcus pyogenes thiol proteinase (Streptococcus pyrogenic exotoxin B)
    Infect Immun (2004) 72, 4836-4847. PubMed  Europe PubMed DOI  PMC  EPMC
  62. Watts,A.B. and Brocklehurst,K.
    Streptopain
    [ISSN:0-12-079610-4] (2004) 2, 1245-1249.  V
    63. 2003
  63. [YEAR:9-5-2003]Chen,C.Y., Luo,S.C., Kuo,C.F., Lin,Y.S., Wu,J.J., Lin,M.T., Liu,C.C., Jeng,W.Y. and Chuang,W.J.
    Maturation processing and characterization of streptopain
    J Biol Chem (9-5-2003) 278, 17336-17343. PubMed  Europe PubMed DOI
  64. Eriksson,A. and Norgren,M.
    Cleavage of antigen-bound immunoglobulin G by SpeB contributes to streptococcal persistence in opsonizing blood
    Infect Immun (2003) 71, 211-217. PubMed  Europe PubMed DOI  PMC  EPMC
  65. [YEAR:1-2-2003]Kansal,R.G., Nizet,V., Jeng,A., Chuang,W.J. and Kotb,M.
    Selective modulation of superantigen-induced responses by streptococcal cysteine protease
    J Infect Dis (1-2-2003) 187, 398-407. PubMed  Europe PubMed DOI
  66. Lyon,W.R. and Caparon,M.G.
    Trigger factor-mediated prolyl isomerization influences maturation of the Streptococcus pyogenes cysteine protease
    J Bacteriol (2003) 185, 3661-3667. PubMed  Europe PubMed DOI  PMC  EPMC
  67. Neely,M.N., Lyon,W.R., Runft,D.L. and Caparon,M.
    Role of RopB in growth phase expression of the SpeB cysteine protease of Streptococcus pyogenes
    J Bacteriol (2003) 185, 5166-5174. PubMed  Europe PubMed DOI  PMC  EPMC
  68. von Pawel-Rammingen,U. and Bjorck,L.
    IdeS and SpeB: immunoglobulin-degrading cysteine proteinases of Streptococcus pyogenes
    Curr Opin Microbiol (2003) 6, 50-55. PubMed  Europe PubMed DOI
    69. 2002
  69. Batsford,S., Brundiers,M., Schweier,O., Horbach,E. and Monting,J.S.
    Antibody to streptococcal cysteine proteinase as a seromarker of group A streptococcal (Streptococcus pyogenes) infections
    Scand J Infect Dis (2002) 34, 407-412. PubMed  Europe PubMed DOI
  70. Collin,M., Svensson,M.D., Sjoholm,A.G., Jensenius,J.C., Sjobring,U. and Olsen,A.
    EndoS and SpeB from Streptococcus pyogenes inhibit immunoglobulin-mediated opsonophagocytosis
    Infect Immun (2002) 70, 6646-6651. PubMed  Europe PubMed DOI  PMC  EPMC
    71. 2001
  71. Ashbaugh,C.D. and Wessels,M.R.
    Absence of a cysteine protease effect on bacterial virulence in two murine models of human invasive group A streptococcal infection
    Infect Immun (2001) 69, 6683-6688. PubMed  Europe PubMed DOI  PMC  EPMC
  72. [YEAR:15-6-2001]Collin,M. and Olsen,A.
    EndoS, a novel secreted protein from Streptococcus pyogenes with endoglycosidase activity on human IgG
    EMBO J (15-6-2001) 20, 3046-3055. PubMed  Europe PubMed DOI  PMC  EPMC
  73. Collin,M. and Olsen,A.
    Effect of SpeB and EndoS from Streptococcus pyogenes on human immunoglobulins
    Infect Immun (2001) 69, 7187-7189. PubMed  Europe PubMed DOI  PMC  EPMC
  74. Hytonen,J., Haataja,S., Gerlach,D., Podbielski,A. and Finne,J.
    The SpeB virulence factor of Streptococcus pyogenes, a multifunctional secreted and cell surface molecule with strepadhesin, laminin-binding and cysteine protease activity
    Mol Microbiol (2001) 39, 512-519. PubMed  Europe PubMed DOI
  75. Karlsson,A., Saravia-Otten,P., Tegmark,K., Morfeldt,E. and Arvidson,S.
    Decreased amounts of cell wall-associated protein A and fibronectin-binding proteins in Staphylococcus aureus sarA mutants due to up-regulation of extracellular proteases
    Infect Immun (2001) 69, 4742-4748. PubMed  Europe PubMed DOI  PMC  EPMC
  76. [YEAR:30-11-2001]Nomizu,M., Pietrzynski,G., Kato,T., Lachance,P., Menard,R. and Ziomek,E.
    Substrate specificity of the streptococcal cysteine protease
    J Biol Chem (30-11-2001) 276, 44551-44556. PubMed  Europe PubMed DOI  P
  77. Viera,N.T., Romero,M.J., Montero,M.K., Rincon,J. and Mosquera,J.A.
    Streptococcal erythrogenic toxin B induces apoptosis and proliferation in human leukocytes
    Kidney Int (2001) 59, 950-958. PubMed  Europe PubMed DOI
    78. 2000
  78. Chaussee,M.S., Cole,R.L. and van Putten,J.P.
    Streptococcal erythrogenic toxin B abrogates fibronectin-dependent internalization of Streptococcus pyogenes by cultured mammalian cells
    Infect Immun (2000) 68, 3226-3232. PubMed  Europe PubMed DOI  PMC  EPMC
  79. Collin,M. and Olsen,A.
    Generation of a mature streptococcal cysteine proteinase is dependent on cell wall-anchored M1 protein
    Mol Microbiol (2000) 36, 1306-1318. PubMed  Europe PubMed DOI
  80. Gubba,S., Cipriano,V. and Musser,J.M.
    Replacement of histidine 340 with alanine inactivates the group A Streptococcus extracellular cysteine protease virulence factor
    Infect Immun (2000) 68, 3716-3719. PubMed  Europe PubMed DOI  PMC  EPMC
  81. [YEAR:29-2-2000]Kagawa,T.F., Cooney,J.C., Baker,H.M., McSweeney,S., Liu,M.Y., Gubba,S., Musser,J.M. and Baker,E.N.
    Crystal structure of the zymogen form of the group A Streptococcus virulence factor SpeB: an integrin-binding cysteine protease
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