Literature for peptidase C10.001: streptopain

(Topics flags: A Assay, S Structure, P Specificity, I Inhibitor, E Expression, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

2025
1. Vassen,V., Tanaka,E., Moll,K., Spoerry,C., Synowsky,S., Shirran,S.L., Schwarz-Linek,U., Loh,E., Svensson,M. and Norrby-Teglund,A.
   Group A streptococcal SpeB modifies IgA through targeting regions other than the hinge
   Microbiol Spectre0245024-e0245024. PubMed  Europe PubMed DOI
2024
2. Zhu,B., Lane,M.D., Baller,J.A., Jagtap,P.D., Griffin,T.J. and Seelig,B.
   Comprehensive protease specificity profiling
   bioRxiv PubMed  Europe PubMed DOI
2023
3. Chiang-Ni,C., Chiang,C.Y., Chen,Y.W., Shi,Y.A., Chao,Y.T., Wang,S., Tsai,P.J. and Chiu,C.H.
   RopB-regulated SpeB cysteine protease degrades extracellular vesicles-associated streptolysin O and bacterial proteins from group A Streptococcus
   Virulence14, 2249784-2249784. PubMed  Europe PubMed DOI
2022
4. Deng,W., Bai,Y., Deng,F., Pan,Y., Mei,S., Zheng,Z., Min,R., Wu,Z., Li,W., Miao,R., Zhang,Z., Kupper,T.S., Lieberman,J. and Liu,X.
   Streptococcal pyrogenic exotoxin B cleaves GSDMA and triggers pyroptosis
   Nature602, 496-502. PubMed  Europe PubMed DOI
5. LaRock,D.L., Johnson,A.F., Wilde,S., Sands,J.S., Monteiro,M.P. and LaRock,C.N.
   Group A Streptococcus induces GSDMA-dependent pyroptosis in keratinocytes
   Nature605, 527-531. PubMed  Europe PubMed DOI
2020
6. Woehl,J.L., Kitamura,S., Dillon,N., Han,Z., Edgar,L.J., Nizet,V. and Wolan,D.W.
   An Irreversible Inhibitor to Probe the Role of Streptococcus pyogenes Cysteine Protease SpeB in Evasion of Host Complement Defenses
   ACS Chem Biol15, 2060-2069. PubMed  Europe PubMed DOI  I
2018
7. Brouwer,S., Cork,A.J., Ong,C.Y., Barnett,T.C., West,N.P., McIver,K.S. and Walker,M.J.
   The endopeptidase PepO regulates the SpeB cysteine protease and is essential for the virulence of invasive M1T1 Streptococcus pyogenes
   J Bacteriol200, e00654-17-e00654-17. PubMed  Europe PubMed DOI
8. Sumitomo,T., Mori,Y., Nakamura,Y., Honda-Ogawa,M., Nakagawa,S., Yamaguchi,M., Matsue,H., Terao,Y., Nakata,M. and Kawabata,S.
   Streptococcal cysteine protease-mediated cleavage of desmogleins is involved in the pathogenesis of cutaneous infection
   Front Cell Infect Microbiol8, 10-10. PubMed  Europe PubMed DOI
2017
9. Do,H., Makthal,N., VanderWal,A.R., Rettel,M., Savitski,M.M., Peschek,N., Papenfort,K., Olsen,R.J., Musser,J.M. and Kumaraswami,M.
   Leaderless secreted peptide signaling molecule alters global gene expression and increases virulence of a human bacterial pathogen
   Proc Natl Acad Sci U S A114, E8498-E8498. PubMed  Europe PubMed DOI
10. Sjogren,J., Andersson,L., Mejare,M. and Olsson,F.
    Generating and purifying Fab fragments from human and mouse IgG using the bacterial enzymes IdeS, SpeB and Kgp
    Methods Mol Biol1535, 319-329. PubMed  Europe PubMed DOI
2016
11. Arzanlou,M.
    Inhibition of streptococcal pyrogenic exotoxin B using allicin from garlic
    Microb Pathog93, 166-171. PubMed  Europe PubMed DOI  I
12. Lane,M.D. and Seelig,B.
    Highly efficient recombinant production and purification of streptococcal cysteine protease streptopain with increased enzymatic activity
    Protein Expr Purif121, 66-72. PubMed  Europe PubMed DOI  E
13. Zhang,Z., Perrault,R., Zhao,Y. and Ding,J.
    SpeB proteolysis with imaged capillary isoelectric focusing for the characterization of domain-specific charge heterogeneities of reference and biosimilar Rituximab
    J Chromatogr B Analyt Technol Biomed Life Sci1020, 148-157. PubMed  Europe PubMed DOI
2015
14. Olsen,R.J., Raghuram,A., Cantu,C., Hartman,M.H., Jimenez,F.E., Lee,S., Ngo,A., Rice,K.A., Saddington,D., Spillman,H., Valson,C., Flores,A.R., Beres,S.B., Long,S.W., Nasser,W. and Musser,J.M.
    The majority of 9,729 group A streptococcus strains causing disease secrete SpeB cysteine protease: pathogenesis implications
    Infect Immun83, 4750-4758. PubMed  Europe PubMed DOI
15. Wang,A.Y., Gonzalez-Paez,G.E. and Wolan,D.W.
    Identification and co-complex structure of a new S. pyogenes SpeB small molecule inhibitor
    Biochemistry54, 4365-4373. PubMed  Europe PubMed DOI  S  I
2014
16. Chella Krishnan,K., Mukundan,S., Landero Figueroa,J.A., Caruso,J.A. and Kotb,M.
    Metal-mediated modulation of Streptococcal cysteine protease activity and its biological implications
    Infect Immun82, 2992-3001. PubMed  Europe PubMed DOI
2013
17. Ender,M., Andreoni,F., Zinkernagel,A.S. and Schuepbach,R.A.
    Streptococcal SpeB cleaved PAR-1 suppresses ERK phosphorylation and blunts thrombin-induced platelet aggregation
    PLoS ONE8, e81298-e81298. PubMed  Europe PubMed DOI
18. Honda-Ogawa,M., Ogawa,T., Terao,Y., Sumitomo,T., Nakata,M., Ikebe,K., Maeda,Y. and Kawabata,S.
    Cysteine proteinase from Streptococcus pyogenes enables evasion of innate immunity via degradation of complement factors
    J Biol Chem288, 15854-15864. PubMed  Europe PubMed DOI
19. Nakagawa,I.
    Streptococcus pyogenes escapes from autophagy
    Cell Host Microbe14, 604-606. PubMed  Europe PubMed DOI
20. Persson,H., Vindebro,R. and von Pawel-Rammingen,U.
    The streptococcal cysteine protease SpeB is not a natural immunoglobulin-cleaving enzyme
    Infect Immun81, 2236-2241. PubMed  Europe PubMed DOI
21. Sumitomo,T., Nakata,M., Higashino,M., Terao,Y. and Kawabata,S.
    Group A streptococcal cysteine protease cleaves epithelial junctions and contributes to bacterial translocation
    J Biol Chem288, 13317-13324. PubMed  Europe PubMed DOI
2012
22. Chiang-Ni,C., Zheng,P.X., Tsai,P.J., Chuang,W.J., Lin,Y.S., Liu,C.C. and Wu,J.J.
    Environmental pH changes, but not the LuxS signalling pathway, regulate SpeB expression in M1 group A streptococci
    J Med Microbiol61, 16-22. PubMed  Europe PubMed DOI
23. Chuang,W.J., Lin,Y.S., Wu,J.J., Liu,C.C. and Lin,M.T.
    Streptopain
    [ISSN:978-0-12-407743-0]3, 2142-2150. DOI
24. Gonzalez-Paez,G.E. and Wolan,D.W.
    Ultrahigh and high resolution structures and mutational analysis of monomeric Streptococcus pyogenes SpeB reveal a functional role for the glycine-rich C-terminal loop
    J Biol Chem287, 24412-24426. PubMed  Europe PubMed DOI  A  S  I
25. Minami,M., Ichikawa,M., Ohta,M. and Hasegawa,T.
    The cell envelope-associated protein, LytR, regulates the cysteine protease SpeB in Streptococcus pyogenes
    APMIS120, 417-426. PubMed  Europe PubMed DOI
26. Olsen,R.J., Laucirica,D.R., Watkins,M.E., Feske,M.L., Garcia-Bustillos,J.R., Vu,C., Cantu,C., Shelburne,S.A., III, Fittipaldi,N., Kumaraswami,M., Shea,P.R., Flores,A.R., Beres,S.B., Lovgren,M., Tyrrell,G.J., Efstratiou,A., Low,D.E., Van Beneden,C.A. and Musser,J.M.
    Polymorphisms in regulator of protease B (RopB) alter disease phenotype and strain virulence of serotype M3 group A Streptococcus
    J Infect Dis205, 1719-1729. PubMed  Europe PubMed DOI
2011
27. Carroll,R.K. and Musser,J.M.
    From transcription to activation: how group A streptococcus, the flesh-eating pathogen, regulates SpeB cysteine protease production
    Mol Microbiol81, 588-601. PubMed  Europe PubMed DOI
28. Connolly,K.L., Roberts,A.L., Holder,R.C. and Reid,S.D.
    Dispersal of Group A streptococcal biofilms by the cysteine protease SpeB leads to increased disease severity in a murine model
    PLoS ONE6, e18984-e18984. PubMed  Europe PubMed DOI
29. Meinert Niclasen,L., Olsen,J.G., Dagil,R., Qing,Z., Sorensen,O.E. and Kragelund,B.B.
    Streptococcal pyogenic exotoxin B (SpeB) boosts the contact system via binding of alpha-1 antitrypsin
    Biochem J434, 123-132. PubMed  Europe PubMed DOI
30. Nelson,D.C., Garbe,J. and Collin,M.
    Cysteine proteinase SpeB from Streptococcus pyogenes - a potent modifier of immunologically important host and bacterial proteins
    Biol Chem392, 1077-1088. PubMed  Europe PubMed DOI  V
2010
31. Luo,Y.H., Chuang,W.J., Wu,J.J., Lin,M.T., Liu,C.C., Lin,P.Y., Roan,J.N., Wong,T.W., Chen,Y.L. and Lin,Y.S.
    Molecular mimicry between streptococcal pyrogenic exotoxin B and endothelial cells
    Lab Invest90, 1492-1506. PubMed  Europe PubMed DOI
32. Olsen,R.J., Sitkiewicz,I., Ayeras,A.A., Gonulal,V.E., Cantu,C., Beres,S.B., Green,N.M., Lei,B., Humbird,T., Greaver,J., Chang,E., Ragasa,W.P., Montgomery,C.A., Cartwright,J., Jr., McGeer,A., Low,D.E., Whitney,A.R., Cagle,P.T., Blasdel,T.L., DeLeo,F.R. and Musser,J.M.
    Decreased necrotizing fasciitis capacity caused by a single nucleotide mutation that alters a multiple gene virulence axis
    Proc Natl Acad Sci U S A107, 888-893. PubMed  Europe PubMed DOI
33. Roberts,A.L., Holder,R.C. and Reid,S.D.
    Allelic replacement of the streptococcal cysteine protease SpeB in a deltasrv mutant background restores biofilm formation
    BMC Res Notes3, 281-281. PubMed  Europe PubMed DOI
2009
34. Doern,C.D., Roberts,A.L., Hong,W., Nelson,J., Lukomski,S., Swords,W.E. and Reid,S.D.
    Biofilm formation by group A Streptococcus: a role for the streptococcal regulator of virulence (Srv) and streptococcal cysteine protease (SpeB)
    Microbiology (Reading)155, 46-52. PubMed  Europe PubMed DOI
35. Ma,Y., Bryant,A.E., Salmi,D.B., McIndoo,E. and Stevens,D.L.
    vfr, a novel locus affecting cysteine protease production in Streptococcus pyogenes
    J Bacteriol191, 3189-3194. PubMed  Europe PubMed DOI
36. Olsen,J.G., Dagil,R., Niclasen,L.M., Sorensen,O.E. and Kragelund,B.B.
    Structure of the mature streptococcal cysteine protease exotoxin mSpeB in its active dimeric form
    J Mol Biol393, 693-703. PubMed  Europe PubMed DOI  S
37. Wang,C.C., Houng,H.C., Chen,C.L., Wang,P.J., Kuo,C.F., Lin,Y.S., Wu,J.J., Lin,M.T., Liu,C.C., Huang,W. and Chuang,W.J.
    Solution structure and backbone dynamics of streptopain: insight into diverse substrate specificity
    J Biol Chem284, 10957-10967. PubMed  Europe PubMed DOI  S
2008
38. Allhorn,M., Olsen,A. and Collin,M.
    EndoS from Streptococcus pyogenes is hydrolyzed by the cysteine proteinase SpeB and requires glutamic acid 235 and tryptophans for IgG glycan-hydrolyzing activity
    BMC Microbiol8, 3-3. PubMed  Europe PubMed DOI
39. Chiang-Ni,C. and Wu,J.J.
    Effects of streptococcal pyrogenic exotoxin B on pathogenesis of Streptococcus pyogenes
    J Formos Med Assoc107, 677-685. PubMed  Europe PubMed DOI  V
40. Hollands,A., Aziz,R.K., Kansal,R., Kotb,M., Nizet,V. and Walker,M.J.
    A naturally occurring mutation in ropB suppresses SpeB expression and reduces M1T1 group A streptococcal systemic virulence
    PLoS ONE3, e4102-e4102. PubMed  Europe PubMed DOI
41. Hsu,J.F., Chuang,W.J., Shiesh,S.C., Lin,Y.S., Liu,C.C., Wang,C.C., Fu,T.F., Tsai,J.H., Tsai,W.L., Huang,Y.J., Hsieh,Y.H., Wu,J.J., Lin,M.T. and Huang,W.
    Streptococcal pyrogenic exotoxin B cleaves human S-adenosylhomocysteine hydrolase and induces hypermethioninemia
    J Infect Dis198, 367-374. PubMed  Europe PubMed DOI
42. Johansson,L., Thulin,P., Sendi,P., Hertzen,E., Linder,A., Akesson,P., Low,D.E., Agerberth,B. and Norrby-Teglund,A.
    Cathelicidin LL-37 in severe Streptococcus pyogenes soft tissue infections in humans
    Infect Immun76, 3399-3404. PubMed  Europe PubMed DOI
43. Kuo,C.F., Lin,Y.S., Chuang,W.J., Wu,J.J. and Tsao,N.
    Degradation of complement 3 by streptococcal pyrogenic exotoxin B inhibits complement activation and neutrophil opsonophagocytosis
    Infect Immun76, 1163-1169. PubMed  Europe PubMed DOI
44. Terao,Y., Mori,Y., Yamaguchi,M., Shimizu,Y., Ooe,K., Hamada,S. and Kawabata,S.
    Group A streptococcal cysteine protease degrades C3 (C3b) and contributes to evasion of innate immunity
    J Biol Chem283, 6253-6260. PubMed  Europe PubMed DOI
45. Ulrich,R.G.
    Vaccine based on a ubiquitous cysteinyl protease and streptococcal pyrogenic exotoxin A protects against Streptococcus pyogenes sepsis and toxic shock
    J Immune Based Ther Vaccines6, 8-8. PubMed  Europe PubMed DOI
2007
46. Cole,J.N., Aquilina,J.A., Hains,P.G., Henningham,A., Sriprakash,K.S., Caparon,M.G., Nizet,V., Kotb,M., Cordwell,S.J., Djordjevic,S.P. and Walker,M.J.
    Role of group A Streptococcus HtrA in the maturation of SpeB protease
    Proteomics7, 4488-4498. PubMed  Europe PubMed DOI
2006
47. [YEAR:21-6-2006]Cole,J.N., McArthur,J.D., McKay,F.C., Sanderson-Smith,M.L., Cork,A.J., Ranson,M., Rohde,M., Itzek,A., Sun,H., Ginsburg,D., Kotb,M., Nizet,V., Chhatwal,G.S. and Walker,M.J.
    Trigger for group A streptococcal M1T1 invasive disease
    FASEB J20, 1745-1747. PubMed  Europe PubMed DOI
48. Loughman,J.A. and Caparon,M.
    Regulation of SpeB in Streptococcus pyogenes by pH and NaCl: a model for in vivo gene expression
    J Bacteriol188, 399-408. PubMed  Europe PubMed DOI
49. [YEAR:15-9-2006]Nooh,M.M., Aziz,R.K., Kotb,M., Eroshkin,A., Chuang,W.J., Proft,T. and Kansal,R.
    Streptococcal mitogenic exotoxin, SmeZ, is the most susceptible M1T1 streptococcal superantigen to degradation by the streptococcal cysteine protease, SpeB
    J Biol Chem281, 35281-35288. PubMed  Europe PubMed DOI
50. [YEAR:20-1-2006]Tsao,N., Tsai,W.H., Lin,Y.S., Chuang,W.J., Wang,C.H. and Kuo,C.F.
    Streptococcal pyrogenic exotoxin B cleaves properdin and inhibits complement-mediated opsonophagocytosis
    Biochem Biophys Res Commun339, 779-784. PubMed  Europe PubMed DOI
2005
51. [YEAR:15-4-2005]Anderson,E.T., Winter,L.A., Fernsten,P., Olmsted,S.B. and Matsuka,Y.V.
    The pro-sequence domain of streptopain directs the folding of the mature enzyme
    Arch Biochem Biophys436, 297-306. PubMed  Europe PubMed DOI
52. Kagawa,T.F., O'Toole,P.W. and Cooney,J.C.
    SpeB-Spi: a novel protease-inhibitor pair from Streptococcus pyogenes
    Mol Microbiol57, 650-666. PubMed  Europe PubMed DOI
53. Rosch,J.W. and Caparon,M.G.
    The ExPortal: an organelle dedicated to the biogenesis of secreted proteins in Streptococcus pyogenes
    Mol Microbiol58, 959-968. PubMed  Europe PubMed DOI
54. Wei,L., Pandiripally,V., Gregory,E., Clymer,M. and Cue,D.
    Impact of the SpeB protease on binding of the complement regulatory proteins factor H and factor H-like protein 1 by Streptococcus pyogenes
    Infect Immun73, 2040-2050. PubMed  Europe PubMed DOI
55. Zimmerlein,B., Park,H.S., Li,S., Podbielski,A. and Cleary,P.P.
    The M protein is dispensable for maturation of streptococcal cysteine protease SpeB
    Infect Immun73, 859-864. PubMed  Europe PubMed DOI
2004
56. Aziz,R.K., Pabst,M.J., Jeng,A., Kansal,R., Low,D.E., Nizet,V. and Kotb,M.
    Invasive M1T1 group A Streptococcus undergoes a phase-shift in vivo to prevent proteolytic degradation of multiple virulence factors by SpeB
    Mol Microbiol51, 123-134. PubMed  Europe PubMed DOI
57. Kuo,C.F., Luo,Y.H., Lin,H.Y., Huang,K.J., Wu,J.J., Lei,H.Y., Lin,M.T., Chuang,W.J., Liu,C.C., Jin,Y.T. and Lin,Y.S.
    Histopathologic changes in kidney and liver correlate with streptococcal pyrogenic exotoxin B production in the mouse model of group A streptococcal infection
    Microb Pathog36, 273-285. PubMed  Europe PubMed DOI
58. Lyon,W.R. and Caparon,M.G.
    Role for serine protease HtrA (DegP) of Streptococcus pyogenes in the biogenesis of virulence factors SpeB and the hemolysin streptolysin S
    Infect Immun72, 1618-1625. PubMed  Europe PubMed DOI
59. Nyberg,P., Rasmussen,M., von Pawel-Rammingen,U. and Bjorck,L.
    SpeB modulates fibronectin-dependent internalization of Streptococcus pyogenes by efficient proteolysis of cell-wall-anchored protein F1
    Microbiology (Reading, Engl )150, 1559-1569. PubMed  Europe PubMed
60. Ohkuni,H., Todome,Y., Watanabe,Y., Ishikaw,T., Takahashi,H., Kannari,Y., Kato,H., Uchiyama,T., Saito,H., Fischetti,V.A. and Zabriskie,J.B.
    Studies of recombinant streptococcal pyrogenic exotoxin B/cysteine protease (rSPE B/SCP) in the skin of guinea pigs & the release of histamine from cultured mast cells & basophilic leukocytes
    Indian J Med Res119 Suppl, 33-36. PubMed  Europe PubMed
61. Tamura,F., Nakagawa,R., Akuta,T., Okamoto,S., Hamada,S., Maeda,H., Kawabata,S. and Akaike,T.
    Proapoptotic effect of proteolytic activation of matrix metalloproteinases by Streptococcus pyogenes thiol proteinase (Streptococcus pyrogenic exotoxin B)
    Infect Immun72, 4836-4847. PubMed  Europe PubMed DOI
62. Watts,A.B. and Brocklehurst,K.
    Streptopain
    [ISSN:0-12-079610-4]2, 1245-1249.  V
2003
63. [YEAR:9-5-2003]Chen,C.Y., Luo,S.C., Kuo,C.F., Lin,Y.S., Wu,J.J., Lin,M.T., Liu,C.C., Jeng,W.Y. and Chuang,W.J.
    Maturation processing and characterization of streptopain
    J Biol Chem278, 17336-17343. PubMed  Europe PubMed DOI
64. Eriksson,A. and Norgren,M.
    Cleavage of antigen-bound immunoglobulin G by SpeB contributes to streptococcal persistence in opsonizing blood
    Infect Immun71, 211-217. PubMed  Europe PubMed DOI
65. [YEAR:1-2-2003]Kansal,R.G., Nizet,V., Jeng,A., Chuang,W.J. and Kotb,M.
    Selective modulation of superantigen-induced responses by streptococcal cysteine protease
    J Infect Dis187, 398-407. PubMed  Europe PubMed DOI
66. Lyon,W.R. and Caparon,M.G.
    Trigger factor-mediated prolyl isomerization influences maturation of the Streptococcus pyogenes cysteine protease
    J Bacteriol185, 3661-3667. PubMed  Europe PubMed DOI
67. Neely,M.N., Lyon,W.R., Runft,D.L. and Caparon,M.
    Role of RopB in growth phase expression of the SpeB cysteine protease of Streptococcus pyogenes
    J Bacteriol185, 5166-5174. PubMed  Europe PubMed DOI
68. von Pawel-Rammingen,U. and Bjorck,L.
    IdeS and SpeB: immunoglobulin-degrading cysteine proteinases of Streptococcus pyogenes
    Curr Opin Microbiol6, 50-55. PubMed  Europe PubMed DOI
2002
69. Batsford,S., Brundiers,M., Schweier,O., Horbach,E. and Monting,J.S.
    Antibody to streptococcal cysteine proteinase as a seromarker of group A streptococcal (Streptococcus pyogenes) infections
    Scand J Infect Dis34, 407-412. PubMed  Europe PubMed DOI
70. Collin,M., Svensson,M.D., Sjoholm,A.G., Jensenius,J.C., Sjobring,U. and Olsen,A.
    EndoS and SpeB from Streptococcus pyogenes inhibit immunoglobulin-mediated opsonophagocytosis
    Infect Immun70, 6646-6651. PubMed  Europe PubMed DOI
2001
71. Ashbaugh,C.D. and Wessels,M.R.
    Absence of a cysteine protease effect on bacterial virulence in two murine models of human invasive group A streptococcal infection
    Infect Immun69, 6683-6688. PubMed  Europe PubMed DOI
72. [YEAR:15-6-2001]Collin,M. and Olsen,A.
    EndoS, a novel secreted protein from Streptococcus pyogenes with endoglycosidase activity on human IgG
    EMBO J20, 3046-3055. PubMed  Europe PubMed DOI
73. Collin,M. and Olsen,A.
    Effect of SpeB and EndoS from Streptococcus pyogenes on human immunoglobulins
    Infect Immun69, 7187-7189. PubMed  Europe PubMed DOI
74. Hytonen,J., Haataja,S., Gerlach,D., Podbielski,A. and Finne,J.
    The SpeB virulence factor of Streptococcus pyogenes, a multifunctional secreted and cell surface molecule with strepadhesin, laminin-binding and cysteine protease activity
    Mol Microbiol39, 512-519. PubMed  Europe PubMed DOI
75. Karlsson,A., Saravia-Otten,P., Tegmark,K., Morfeldt,E. and Arvidson,S.
    Decreased amounts of cell wall-associated protein A and fibronectin-binding proteins in Staphylococcus aureus sarA mutants due to up-regulation of extracellular proteases
    Infect Immun69, 4742-4748. PubMed  Europe PubMed DOI
76. [YEAR:30-11-2001]Nomizu,M., Pietrzynski,G., Kato,T., Lachance,P., Menard,R. and Ziomek,E.
    Substrate specificity of the streptococcal cysteine protease
    J Biol Chem276, 44551-44556. PubMed  Europe PubMed DOI  P
77. Viera,N.T., Romero,M.J., Montero,M.K., Rincon,J. and Mosquera,J.A.
    Streptococcal erythrogenic toxin B induces apoptosis and proliferation in human leukocytes
    Kidney Int59, 950-958. PubMed  Europe PubMed DOI
2000
78. Chaussee,M.S., Cole,R.L. and van Putten,J.P.
    Streptococcal erythrogenic toxin B abrogates fibronectin-dependent internalization of Streptococcus pyogenes by cultured mammalian cells
    Infect Immun68, 3226-3232. PubMed  Europe PubMed DOI
79. Collin,M. and Olsen,A.
    Generation of a mature streptococcal cysteine proteinase is dependent on cell wall-anchored M1 protein
    Mol Microbiol36, 1306-1318. PubMed  Europe PubMed DOI
80. Gubba,S., Cipriano,V. and Musser,J.M.
    Replacement of histidine 340 with alanine inactivates the group A Streptococcus extracellular cysteine protease virulence factor
    Infect Immun68, 3716-3719. PubMed  Europe PubMed DOI
81. [YEAR:29-2-2000]Kagawa,T.F., Cooney,J.C., Baker,H.M., McSweeney,S., Liu,M.Y., Gubba,S., Musser,J.M. and Baker,E.N.
    Crystal structure of the zymogen form of the group A Streptococcus virulence factor SpeB: an integrin-binding cysteine protease
    Proc Natl Acad Sci U S A97, 2235-2240. PubMed  Europe PubMed DOI  S
82. Kansal,R.G., McGeer,A., Low,D.E., Norrby-Teglund,A. and Kotb,M.
    Inverse relation between disease severity and expression of the streptococcal cysteine protease, SpeB, among clonal M1T1 isolates recovered from invasive group A streptococcal infection cases
    Infect Immun68, 6362-6369. PubMed  Europe PubMed DOI
83. Mylvaganam,H., Bjorvatn,B. and Osland,A.
    Distribution and sequence variations of selected virulence genes among group A streptococcal isolates from western Norway
    APMIS108, 771-778. PubMed  Europe PubMed
84. Svensson,M.D., Scaramuzzino,D.A., Sjobring,U., Olsen,A., Frank,C. and Bessen,D.E.
    Role for a secreted cysteine proteinase in the establishment of host tissue tropism by group A streptococci
    Mol Microbiol38, 242-253. PubMed  Europe PubMed DOI
85. Woischnik,M., Buttaro,B.A. and Podbielski,A.
    Inactivation of the cysteine protease SpeB affects hyaluronic acid capsule expression in group A streptococci
    Microb Pathog28, 221-226. PubMed  Europe PubMed DOI
1999
86. Doran,J.D., Nomizu,M., Takebe,S., Menard,R., Griffith,D. and Ziomek,E.
    Autocatalytic processing of the streptococcal cysteine protease zymogen: processing mechanism and characterization of the autoproteolytic cleavage sites
    Eur J Biochem263, 145-151. PubMed  Europe PubMed DOI
87. Eriksson,A. and Norgren,M.
    The superantigenic activity of streptococcal pyrogenic exotoxin B is independent of the protease activity
    FEMS Immunol Med Microbiol25, 355-363. PubMed  Europe PubMed DOI
88. Lukomski,S., Montgomery,C.A., Rurangirwa,J., Geske,R.S., Barrish,J.P., Adams,G.J. and Musser,J.M.
    Extracellular cysteine protease produced by Streptococcus pyogenes participates in the pathogenesis of invasive skin infection and dissemination in mice
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