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Literature for peptidase C06.001: potato virus Y-type helper component peptidase

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

(Topics flags: S Structure, M Mutation, P Specificity, E Expression, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Pan,Z.J., Wei,W.L., Tran,P.A., Fang,R.Y., Pham,T.H., Bowman,J.L., Chung,C.T., Shen,B.N., Yang,J.T., Chang,H.H., Jane,W.N., Cheng,C.H., Wang,C.C., Wu,H.Y., Hong,S.F., Shang,Q.W., Hu,S.F., Lin,P.C., Wu,F.H., Lin,C.S., Hung,Y.L., Shen,T.L. and Lin,S.S.
    HC-Pro inhibits HEN1 methyltransferase activity, leading to autophagic degradation of AGO1
    Nat Commun16, 2503-2503. PubMed  Europe PubMed DOI
    2. 2024
  2. Alex,B.G., Zhang,Z.Y., Lasky,D., Garcia-Ruiz,H., Dewberry,R., Allen,C., Halterman,D. and Rakotondrafara,A.M.
    A single phosphorylatable amino acid residue is essential for the recognition of multiple potyviral HCPro effectors by potato Ny(tbr)
    Mol Plant Pathol25, e70027-e70027. PubMed  Europe PubMed DOI
  3. Parrella,G. and Moury,B.
    A new point mutation in the HC-Pro of potato virus Y is involved in tobacco vein necrosis
    PLoS ONE19, e0302692-e0302692. PubMed  Europe PubMed DOI
    4. 2023
  4. Cheng,H.W., Lin,T.T., Huang,C.H., Raja,J.A.J. and Yeh,S.D.
    Modification of papaya ringspot virus HC-Pro to generate effective attenuated mutants for overcoming the problem of strain-specific cross protection
    Plant Dis107, 1757-1768. PubMed  Europe PubMed DOI
  5. Goh,R.P., Xie,X.Y., Lin,Y.C., Cheng,H.W., Raja,J.A.J. and Yeh,S.D.
    Rapid selection of potyviral cross-protection effective mutants from the local lesion host after nitrous acid mutagenesis
    Mol Plant Pathol24, 973-988. PubMed  Europe PubMed DOI
    6. 2022
  6. Saha,S., Lohmus,A., Dutta,P., Pollari,M. and Makinen,K.
    Interplay of HCPro and CP in the Regulation of Potato Virus A RNA Expression and Encapsidation
    Viruses14, PubMed  Europe PubMed DOI
    7. 2020
  7. Bao,W., Yan,T., Deng,X. and Wuriyanghan,H.
    Synthesis of Full-Length cDNA Infectious Clones of Soybean Mosaic Virus and Functional Identification of a Key Amino Acid in the Silencing Suppressor Hc-Pro
    Viruses12, PubMed  Europe PubMed DOI
  8. Tuo,D., Zhou,P., Zhao,G., Yan,P., Tan,D., Li,X. and Shen,W.
    A double mutation in the conserved motifs of the helper component protease of papaya leaf distortion mosaic virus for the generation of a cross-protective attenuated strain
    Phytopathology110, 187-193. PubMed  Europe PubMed DOI
  9. Yang,T., Qiu,L., Huang,W., Xu,Q., Zou,J., Peng,Q., Lin,H. and Xi,D.
    Chilli veinal mottle virus HCPro interacts with catalase to facilitate virus infection in Nicotiana tabacum
    J Exp Bot71, 5656-5668. PubMed  Europe PubMed DOI
    10. 2018
  10. Valli,A.A., Gallo,A., Rodamilans,B., Lopez-Moya,J.J. and Garcia,J.A.
    The HCPro from the potyviridae family: an enviable multitasking helper component that every virus would like to have
    Mol Plant Pathol19, 744-763. PubMed  Europe PubMed DOI
    11. 2015
  11. Tu,Y., Zhang,Z., Li,D., Li,H., Dong,J. and Wang,T.
    Potato virus Y HC-Pro reduces the ATPase activity of NtMinD, which results in enlarged chloroplasts in HC-Pro transgenic tobacco
    PLoS ONE10, e0136210-e0136210. PubMed  Europe PubMed DOI
    12. 2014
  12. Sahana,N., Kaur,H., Jain,R.K., Palukaitis,P., Canto,T. and Praveen,S.
    The asparagine residue in the FRNK box of potyviral helper-component protease is critical for its small RNA binding and subcellular localization
    J Gen Virol95, 1167-1177. PubMed  Europe PubMed DOI
  13. Valli,A., Gallo,A., Calvo,M., Perez,J.J. and Garcia,J.A.
    A novel role of the potyviral helper component proteinase contributes to enhance the yield of viral particles
    J Virol88, 9808-9818. PubMed  Europe PubMed DOI
    14. 2013
  14. Haikonen,T., Rajamaki,M.L., Tian,Y.P. and Valkonen,J.P.
    Mutation of a short variable region in HCpro protein of potato virus A affects interactions with a microtubule-associated protein and induces necrotic responses in tobacco
    Mol Plant Microbe Interact26, 721-733. PubMed  Europe PubMed DOI
  15. Haikonen,T., Rajamaki,M.L. and Valkonen,J.P.
    Improved silencing suppression and enhanced heterologous protein expression are achieved using an engineered viral helper component proteinase
    J Virol Methods193, 687-692. PubMed  Europe PubMed DOI
    16. 2012
  16. Atsumi,G., Nakahara,K.S., Wada,T.S., Choi,S.H., Masuta,C. and Uyeda,I.
    Heterologous expression of viral suppressors of RNA silencing complements virulence of the HC-Pro mutant of clover yellow vein virus in pea
    Arch Virol157, 1019-1028. PubMed  Europe PubMed DOI
  17. Faurez,F., Baldwin,T., Tribodet,M. and Jacquot,E.
    Identification of new potato virus Y (PVY) molecular determinants for the induction of vein necrosis in tobacco
    Mol Plant Pathol13, 948-959. PubMed  Europe PubMed DOI  M
  18. Krczal,G. and Wassenegger,M.
    Potyvirus helper component proteinase
    [ISSN:978-0-12-407743-0]3, 2187-2192. DOI
  19. Lim,H.-S., Jang,C.-Y., Nam,J., Li,M., Hong,J.-S., Bae,H., Ju,H.-J., Kim,H.G., Ford,R.E. and Domier,L.L.
    Characterization of the in vitro activities of the P1 and helper component proteases of Soybean mosaic virus strain G2 and Tobacco vein mottling virus
    Plant Pathol J28, 197-201. DOI
    20. 2011
  20. Boonrod,K., Fullgrabe,M.W., Krczal,G. and Wassenegger,M.
    Analysis of the autoproteolytic activity of the recombinant helper component proteinase from zucchini yellow mosaic virus
    Biol Chem392, 937-945. PubMed  Europe PubMed DOI
  21. Fuellgrabe,M.W., Boonrod,K., Jamous,R., Moser,M., Shiboleth,Y., Krczal,G. and Wassenegger,M.
    Expression, purification and functional characterization of recombinant Zucchini yellow mosaic virus HC-Pro
    Protein Expr Purif75, 40-45. PubMed  Europe PubMed DOI  E
  22. Guo,B., Lin,J. and Ye,K.
    Structure of the autocatalytic cysteine protease domain of potyvirus helper-component proteinase
    J Biol Chem286, 21937-21943. PubMed  Europe PubMed DOI  S
  23. Zheng,H., Yan,F., Lu,Y., Sun,L., Lin,L., Cai,L., Hou,M. and Chen,J.
    Mapping the self-interacting domains of TuMV HC-Pro and the subcellular localization of the protein
    Virus Genes42, 110-116. PubMed  Europe PubMed DOI
    24. 2010
  24. Fullgrabe,M., Boonrod,K., Jamous,R., Moser,M., Shiboleth,Y., KrczalK. and Wassenegger,M.
    Expression, purification and functional characterization of recombinant Zucchini yellow mosaic virus HC-Pro
    Protein Expr Purif75, 40-45.  E
  25. Mangrauthia,S.K., Singh,P. and Praveen,S.
    Genomics of helper component proteinase reveals effective strategy for papaya ringspot virus resistance
    Mol Biotechnol44, 22-29. PubMed  Europe PubMed DOI
  26. Seo,J.K., Kang,S.H., Seo,B.Y., Jung,J.K. and Kim,K.H.
    Mutational analysis of interaction between coat protein and helper component-proteinase of Soybean mosaic virus involved in aphid transmission
    Mol Plant Pathol11, 265-276. PubMed  Europe PubMed DOI
  27. Wu,H.W., Lin,S.S., Chen,K.C., Yeh,S.D. and Chua,N.H.
    Discriminating mutations of HC-Pro of Zucchini yellow mosaic virus with differential effects on small RNA pathways involved in viral pathogenicity and symptom development
    Mol Plant Microbe Interact23, 17-28. PubMed  Europe PubMed DOI  M
  28. You,Y. and Shirako,Y.
    Bymovirus reverse genetics: requirements for RNA2-encoded proteins in systemic infection
    Mol Plant Pathol11, 383-394. PubMed  Europe PubMed DOI
    29. 2009
  29. Yap,Y.K., Duangjit,J. and Panyim,S.
    N-terminal of Papaya ringspot virus type-W (PRSV-W) helper component proteinase (HC-Pro) is essential for PRSV systemic infection in zucchini
    Virus Genes38, 461-467. PubMed  Europe PubMed DOI
    30. 2008
  30. Yambao,M.L., Yagihashi,H., Sekiguchi,H., Sekiguchi,T., Sasaki,T., Sato,M., Atsumi,G., Tacahashi,Y., Nakahara,K.S. and Uyeda,I.
    Point mutations in helper component protease of clover yellow vein virus are associated with the attenuation of RNA-silencing suppression activity and symptom expression in broad bean
    Arch Virol153, 105-115. PubMed  Europe PubMed DOI
    31. 2007
  31. Dombrovsky,A., Gollop,N., Chen,S., Chejanovsky,N. and Raccah,B.
    In vitro association between the helper component-proteinase of zucchini yellow mosaic virus and cuticle proteins of Myzus persicae
    J Gen Virol88, 1602-1610. PubMed  Europe PubMed DOI
  32. Lim,H.S., Ko,T.S., Hobbs,H.A., Lambert,K.N., Yu,J.M., McCoppin,N.K., Korban,S.S., Hartman,G.L. and Domier,L.L.
    Soybean mosaic virus helper component-protease alters leaf morphology and reduces seed production in transgenic soybean plants
    Phytopathology97, 366-372. PubMed  Europe PubMed DOI
  33. Lin,S.S., Wu,H.W., Jan,F.J., Hou,R.F. and Yeh,S.D.
    Modifications of the helper component-protease of Zucchini yellow mosaic virus for generation of attenuated mutants for cross protection against severe infection
    Phytopathology97, 287-296. PubMed  Europe PubMed DOI
  34. Shiboleth,Y.M., Haronsky,E., Leibman,D., Arazi,T., Wassenegger,M., Whitham,S.A., Gaba,V. and Gal-On,A.
    The conserved FRNK box in HC-Pro, a plant viral suppressor of gene silencing, is required for small RNA binding and mediates symptom development
    J Virol81, 13135-13148. PubMed  Europe PubMed DOI
  35. Varrelmann,M., Maiss,E., Pilot,R. and Palkovics,L.
    Use of pentapeptide-insertion scanning mutagenesis for functional mapping of the plum pox virus helper component proteinase suppressor of gene silencing
    J Gen Virol88, 1005-1015. PubMed  Europe PubMed DOI
    36. 2005
  36. Ballut,L., Drucker,M., Pugniere,M., Cambon,F., Blanc,S., Roquet,F., Candresse,T., Schmid,H.P., Nicolas,P., Gall,O.L. and Badaoui,S.
    HcPro, a multifunctional protein encoded by a plant RNA virus, targets the 20S proteasome and affects its enzymic activities
    J Gen Virol86, 2595-2603. PubMed  Europe PubMed DOI
  37. Gonzalez-Jara,P., Atencio,F.A., Martinez-Garcia,B., Barajas,D., Tenllado,F. and Diaz-Ruiz,J.R.
    A single amino acid mutation in the Plum pox virus helper component-proteinase gene abolishes both synergistic and rna silencing suppression activities
    Phytopathology95, 894-901. PubMed  Europe PubMed DOI
  38. Ruiz-Ferrer,V., Boskovic,J., Alfonso,C., Rivas,G., Llorca,O., Lopez-Abella,D. and Lopez-Moya,J.J.
    Structural analysis of tobacco etch potyvirus HC-pro oligomers involved in aphid transmission
    J Virol79, 3758-3765. PubMed  Europe PubMed DOI  E
    39. 2004
  39. Verchot-Lubicz,J.
    Potyvirus helper component proteinase
    [ISSN:0-12-079610-4]2, 1262-1264.  V
    40. 2003
  40. Plisson,C., Drucker,M., Blanc,S., German-Retana,S., Le Gall,O., Thomas,D. and Bron,P.
    Structural characterization of HC-Pro, a plant virus multifunctional protein
    J Biol Chem278, 23753-23761. PubMed  Europe PubMed DOI
    41. 2002
  41. Mlotshwa,S., Verver,J., Sithole-Niang,I., Gopinath,K., Carette,J., van Kammen,A. and Wellink,J.
    Subcellular location of the helper component-proteinase of Cowpea aphid-borne mosaic virus
    Virus Genes25, 207-216. PubMed  Europe PubMed DOI
  42. Roudet-Tavert,G., German-Retana,S., Delaunay,T., Delecolle,B., Candresse,T. and Le Gall,O.
    Interaction between potyvirus helper component-proteinase and capsid protein in infected plants
    J Gen Virol83, 1765-1770. PubMed  Europe PubMed
    43. 2001
  43. Mallory,A.C., Ely,L., Smith,T.H., Marathe,R., Anandalakshmi,R., Fagard,M., Vaucheret,H., Pruss,G., Bowman,L. and Vance,V.B.
    HC-Pro suppression of transgene silencing eliminates the small RNAs but not transgene methylation or the mobile signal
    Plant Cell13, 571-583. PubMed  Europe PubMed DOI
  44. [YEAR:10-5-2001]Savenkov,E.I. and Valkonen,J.P.
    Potyviral helper-component proteinase expressed in transgenic plants enhances titers of Potato leaf roll virus but does not alleviate its phloem limitation
    Virology283, 285-293. PubMed  Europe PubMed DOI
    45. 2000
  45. Anandalakshmi,R., Marathe,R., Ge,X., Herr,J.M., Jr., Mau,C., Mallory,A., Pruss,G., Bowman,L. and Vance,V.B.
    A calmodulin-related protein that suppresses posttranscriptional gene silencing in plants
    Science290, 142-144. PubMed  Europe PubMed DOI
  46. Gal-On,A.
    A point mutation in the FRNK motif of the potyvirus helper component-protease gene alters symptom expression in cucurbits and elicits protection against the severe homologous virus
    Phytopathology90, 467-473. PubMed  Europe PubMed DOI
    47. 1999
  47. Andrejeva,J., Puurand,U., Merits,A., Rabenstein,F., Jarvekulg,L. and Valkonen,J.P.
    Potyvirus helper component-proteinase and coat protein (CP) have coordinated functions in virus-host interactions and the same CP motif affects virus transmission and accumulation
    J Gen Virol80, 1133-1139. PubMed  Europe PubMed
  48. Guo,D., Merits,A. and Saarma,M.
    Self-association and mapping of interaction domains of helper component-proteinase of potato A potyvirus
    J Gen Virol80, 1127-1131. PubMed  Europe PubMed
  49. Ohshima,K.
    Accumulation of helper component/proteinase and coat protein of turnip mosaic virus in intact plants
    Acta Virol43, 31-37. PubMed  Europe PubMed
  50. Wang,R.Y. and Pirone,T.P.
    Purification and characterization of turnip mosaic virus helper component protein
    Phytopathology89, 564-567. PubMed  Europe PubMed DOI
    51. 1998
  51. [YEAR:27-10-1998]Anandalakshmi,R., Pruss,G.J., Ge,X., Marathe,R., Mallory,A.C., Smith,T.H. and Vance,V.B.
    A viral suppressor of gene silencing in plants
    Proc Natl Acad Sci U S A95, 13079-13084. PubMed  Europe PubMed
  52. [YEAR:16-11-1998]Brigneti,G., Voinnet,O., Li,W.X., Ji,L.H., Ding,S.W. and Baulcombe,D.C.
    Viral pathogenicity determinants are suppressors of transgene silencing in Nicotiana benthamiana
    EMBO J17, 6739-6746. PubMed  Europe PubMed DOI
  53. Kasschau,K.D. and Carrington,J.C.
    A counterdefensive strategy of plant viruses: suppression of posttranscriptional gene silencing
    Cell95, 461-470. PubMed  Europe PubMed
    54. 1997
  54. Rojas,M.R., Zerbini,F.M., Allison,R.F., Gilbertson,R.L. and Lucas,W.J.
    Capsid protein and helper component-proteinase function as potyvirus cell-to-cell movement proteins
    Virology237, 283-295. PubMed  Europe PubMed DOI
  55. Ryan,M.D. and Flint,M.
    Virus-encoded proteinases of the picornavirus super-group
    J Gen Virol78, 699-723. PubMed  Europe PubMed
    56. 1995
  56. Cronin,S., Verchot,J., Haldeman-Cahill,R., Schaad,M.C. and Carrington,J.C.
    Long-distance movement factor: a transport function of the potyvirus helper component proteinase
    Plant Cell7, 549-559. PubMed  Europe PubMed DOI
    57. 1993
  57. Dolja,V.V., Herndon,K.L., Pirone,T.P. and Carrington,J.C.
    Spontaneous mutagenesis of a plant potyvirus genome after insertion of a foreign gene
    J Virol67, 5968-5975. PubMed  Europe PubMed
  58. Dougherty,W.G. and Semler,B.L.
    Expression of virus-encoded proteinases: functional and structural similarities with cellular enzymes
    Microbiol Rev57, 781-822. PubMed  Europe PubMed
  59. Stram,Y., Chetsrony,A., Karchi,H., Karchi,M., Edelbaum,O., Vardi,E., Livneh,O. and Sela,I.
    Expression of the "helper component" protein of potato virus Y (PVY) in E. coli: possible involvement of a third protease
    Virus Genes7, 151-156. PubMed  Europe PubMed  E
    60. 1992
  60. Atreya,C.D., Atreya,P.L., Thornbury,D.W. and Pirone,T.P.
    Site-directed mutations in the potyvirus HC-Pro gene affect helper component activity, virus accumulation, and symptom expression in infected tobacco plants
    Virology191, 106-111. PubMed  Europe PubMed DOI
  61. Carrington,J.C. and Herndon,K.L.
    Characterization of the potyviral HC-Pro autoproteolytic cleavage site
    Virology187, 308-315. PubMed  Europe PubMed DOI  P
    62. 1991
  62. Choi,G.H., Pawlyk,D.M. and Nuss,D.L.
    The autocatalytic protease p29 encoded by a hypovirulence-associated virus of the chestnut blight fungus resembles the potyvirus-encoded protease HC-Pro
    Virology183, 747-752. PubMed  Europe PubMed DOI
  63. Koonin,E.V., Choi,G.H., Nuss,D.L., Shapira,R. and Carrington,J.C.
    Evidence for common ancestry of a chestnut blight hypovirulence-associated double-stranded RNA and a group of positive-strand RNA plant viruses
    Proc Natl Acad Sci U S A88, 10647-10651. PubMed  Europe PubMed
    64. 1989
  64. Carrington,J.C., Freed,D.D. and Sanders,T.C.
    Autocatalytic processing of the potyvirus helper component proteinase in Escherichia coli and in vitro
    J Virol63, 4459-4463. PubMed  Europe PubMed
  65. Carrington,J.C., Cary,S.M., Parks,T.D. and Dougherty,W.G.
    A second proteinase encoded by a plant potyvirus genome
    EMBO J8, 365-370. PubMed  Europe PubMed
  66. Oh,C.S. and Carrington,J.C.
    Identification of essential residues in potyvirus proteinase HC-Pro by site-directed mutagenesis
    Virology173, 692-699. PubMed  Europe PubMed DOI
    67. 1985
  67. Thornbury,D.W., Hellmann,G.M., Rhoads,R.E. and Pirone,T.P.
    Purification and characterization of potyvirus helper component
    Virology144, 260-267. PubMed  Europe PubMed

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