Literature for subfamily C3C unassigned peptidases

Summary Sequences Sequence features Distribution Structure Literature

(Topics flags: K Knockout, I Inhibitor. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Song,J., Yang,J., Ma,R., Li,Z., Su,J., Xie,S. and Cheng,P.
    Synergetic contributions of Seneca Valley virus 3 C and 3D proteins to induction of ferroptosis for viral replication
    Cell Mol Life Sci (2025) 82, 406-406. PubMed  Europe PubMed DOI  PMC  EPMC
  2. Wu,L., Yuan,Y., Zhao,Z., Yan,Y., Wang,H. and Li,X.
    Z-VAD(OMe)-FMK suppresses Seneca Valley Virus replication by targeting the active sites of the 3C protease
    Int J Biol Macromol (2025) 306, 141587-141587. PubMed  Europe PubMed DOI  I
  3. Wu,L., Yan,Y., Yuan,Y., Zhao,Z., Qu,W., Huang,X., Wang,H., Li,P. and Li,X.
    Viral protease binds to nucleosomal DNA and cleaves nuclear cGAS that attenuates type I interferon
    MBio (2025) , e0339524-e0339524. PubMed  Europe PubMed DOI
  4. Yang,J., Li,Z., Ma,R., Xie,S., Wang,D., Quan,R., Wen,X. and Song,J.
    The Seneca Valley virus 3C protease cleaves DCP1A to attenuate its antiviral effects
    Vet Res (2025) 56, 46-46. PubMed  Europe PubMed DOI  PMC  EPMC
  5. Zhang,X.Y., Li,Y.Y., Zhou,Y.M., Chen,W., Xie,L.L., Hu,Y.Q., Qin,Y., Huang,H.X., Zhou,L., Lan,T. and Sun,W.C.
    Porcine Teschovirus 2 3C(pro) Evades Host Antiviral Innate Immunity by Inhibiting the IFN-beta Signaling Pathway
    Microorganisms (2025) 13 PubMed  Europe PubMed DOI  PMC  EPMC
  6. Zhou,H., Wang,M., Xin,Z., Li,Y. and Liu,F.
    Virulence determinant of Senecavirus A: 3C protein functions as a protease to cleave viral polyprotein and host factors
    Virulence (2025) 16, 2580080-2580080. PubMed  Europe PubMed DOI  PMC  EPMC
  7. 2024
  8. Shi,Y., Wu,Z., Zeng,P., Song,J., Guo,J., Yang,X., Zhou,J., Liu,J. and Hou,L.
    Seneca valley virus 3C protease blocks EphA2-Mediated mTOR activation to facilitate viral replication
    Microb Pathog (2024) 191, 106673-106673. PubMed  Europe PubMed DOI
  9. Zhang,X., Li,P., Chen,W., Zhang,S., Li,K., Ru,Y., Zhao,Z., Cao,W., Yang,F., Tian,H., Guo,J., He,J., Zhu,Z. and Zheng,H.
    Impaired interferon response in senecavirus A infection and identification of 3C(pro) as an antagonist
    J Virol (2024) , e0058524-e0058524. PubMed  Europe PubMed DOI
  10. 2023
  11. Song,J., Guo,Y., Wang,D., Quan,R., Wang,J. and Liu,J.
    Seneca Valley virus 3C(pro) antagonizes type I interferon response by targeting STAT1-STAT2-IRF9 and KPNA1 signals
    J Virol (2023) 97, e0072723-e0072723. PubMed  Europe PubMed DOI  PMC  EPMC
  12. Song,J., Guo,Y., Wang,D., Quan,R., Wang,J. and Liu,J.
    Seneca Valley virus 3C protease cleaves OPTN (optineurin) to Impair selective autophagy and type I interferon signaling
    Autophagy (2023) , 1-15. PubMed  Europe PubMed DOI  K
  13. Zhao,H.F., Meng,L., Geng,Z., Gao,Z.Q., Dong,Y.H., Wang,H.W. and Zhang,H.
    Allosteric regulation of Senecavirus A 3Cpro proteolytic activity by an endogenous phospholipid
    PLoS Pathog (2023) 19, e1011411-e1011411. PubMed  Europe PubMed DOI  PMC  EPMC
  14. 2022
  15. Meng,K., Zhang,L., Xue,X., Xue,Q., Sun,M. and Meng,G.
    Structure of Senecavirus A 3C Protease Revealed the Cleavage Pattern of 3C Protease in Picornaviruses
    J Virol (2022) 96, e0073622-e0073622. PubMed  Europe PubMed DOI  PMC  EPMC
  16. Song,J., Quan,R., Wang,D. and Liu,J.
    Seneca Valley Virus 3C(pro) Mediates Cleavage and Redistribution of Nucleolin To Facilitate Viral Replication
    Microbiol Spectr (2022) 10, e0030422-e0030422. PubMed  Europe PubMed DOI  PMC  EPMC  K
  17. Song,J., Quan,R., Wang,D. and Liu,J.
    Seneca Valley Virus 3C (pro) Cleaves Heterogeneous Nuclear Ribonucleoprotein K to Facilitate Viral Replication
    Front Microbiol (2022) 13, 945443-945443. PubMed  Europe PubMed DOI  PMC  EPMC  K
  18. Wen,W., Zheng,Z., Wang,H., Zhao,Q., Yin,M., Chen,H., Li,X. and Qian,P.
    Seneca Valley Virus Induces DHX30 Cleavage to Antagonize Its Antiviral Effects
    J Virol (2022) 96, e0112122-e0112122. PubMed  Europe PubMed DOI
  19. 2008
  20. Hales,L.M., Knowles,N.J., Reddy,P.S., Xu,L., Hay,C. and Hallenbeck,P.L.
    Complete genome sequence analysis of Seneca Valley virus-001, a novel oncolytic picornavirus
    J Gen Virol (2008) 89, 1265-1275. PubMed  Europe PubMed
  21. 2002
  22. Hinton,T.M., Ross-Smith,N., Warner,S., Belsham,G.J. and Crabb,B.S.
    Conservation of L and 3C proteinase activities across distantly related aphthoviruses
    J Gen Virol (2002) 83, 3111-3121. PubMed  Europe PubMed