Merops Switch to
Inhibitors

Peptidase

Family Clan SEARCHES BLAST
MEROPS SUBMISSIONS

Other
information

Literature for family C3

Family

Summary Holotypes Alignment Tree Genomes Structure Literature Architecture

C3A

Summary Holotypes Alignment Tree Genomes Literature

C3B

Summary Holotypes Alignment Tree Genomes Literature

C3C

Summary Holotypes Alignment Tree Genomes Literature

C3D

Summary Holotypes Alignment Tree Genomes Literature

C3E

Summary Holotypes Alignment Tree Genomes Literature

C3F

Summary Holotypes Alignment Tree Genomes Literature

C3G

Summary Holotypes Alignment Tree Genomes Literature

C3H

Summary Holotypes Alignment Tree Genomes Literature

(Topics flags: S Structure, T Target, I Inhibitor. To select only the references relevant to a single topic, click the link above. See explanation.)

    2017
  1. Li,B., Yue,Y., Zhang,Y., Yuan,Z., Li,P., Song,N., Lin,W., Liu,Y., Gu,L. and Meng,H.
    A novel enterovirus 71 (EV71) virulence determinant: the 69th residue of 3C protease modulates pathogenicity
    Front Cell Infect Microbiol7, 26-26. PubMed  Europe PubMed DOI  S
    2. 2016
  2. Sun,D., Chen,S., Cheng,A. and Wang,M.
    Roles of the picornaviral 3C proteinase in the viral life cycle and host cells
    Viruses8, 82-82. PubMed  Europe PubMed DOI  I
  3. Zhang,Q.-Y., Zhang,W.-H., Xiao,J.-H. and Li,S.
    Broad spectrum inhibitors of 3C and 3CL proteases: research advances
    J Int Pharm Res43, 425-430. DOI  I
    4. 2011
  4. Ramajayam,R., Tan,K.P. and Liang,P.H.
    Recent development of 3C and 3CL protease inhibitors for anti-coronavirus and anti-picornavirus drug discovery
    Biochem Soc Trans39, 1371-1375. PubMed  Europe PubMed DOI  I
    5. 2008
  5. Koonin,E.V., Wolf,Y.I., Nagasaki,K. and Dolja,V.V.
    The Big Bang of picorna-like virus evolution antedates the radiation of eukaryotic supergroups
    Nat Rev Microbiol6, 925-939. PubMed  Europe PubMed DOI
    6. 2007
  6. [YEAR:14-8-2007]Curry,S., Roque-Rosell,N., Zunszain,P.A. and Leatherbarrow,R.J.
    Foot-and-mouth disease virus 3C protease: recent structural and functional insights into an antiviral target
    Int J Biochem Cell Biol39, 1-6. PubMed  Europe PubMed DOI  T
    7. 2006
  7. [YEAR:7-7-2006]Yin,J., Cherney,M.M., Bergmann,E.M., Zhang,J., Huitema,C., Pettersson,H., Eltis,L.D., Vederas,J.C. and James,M.N.
    An episulfide cation (thiiranium ring) trapped in the active site of HAV 3C proteinase inactivated by peptide-based ketone inhibitors
    J Mol Biol361, 673-686. PubMed  Europe PubMed DOI  S  I
    8. 2001
  8. [YEAR:4-9-2001]Sarkany,Z., Szeltner,Z. and Polgar,L.
    Thiolate-imidazolium ion pair is not an obligatory catalytic entity of cysteine peptidases: the active site of picornain 3C
    Biochemistry40, 10601-10606. PubMed  Europe PubMed DOI
    9. 2000
  9. [YEAR:22-9-2000]Sarkany,Z., Skern,T. and Polgar,L.
    Characterization of the active site thiol group of rhinovirus 2A proteinase
    FEBS Lett481, 289-292. PubMed  Europe PubMed DOI  I
    10. 1996
  10. De Francesco,R., Urbani,A., Nardi,M.C., Tomei,L., Steinkuhler,C. and Tramontano,A.
    A zinc binding site in viral serine proteinases
    Biochemistry35, 13282-13287. PubMed  Europe PubMed DOI
    11. 1994
  11. [YEAR:5-5-1994]Allaire,M., Chernaia,M.M., Malcolm,B.A. and James,M.N.
    Picornaviral 3C cysteine proteinases have a fold similar to chymotrypsin-like serine proteinases
    Nature369, 72-76. PubMed  Europe PubMed DOI  S
  12. Matthews,D.A., Smith,W.W., Ferre,R.A., Condon,B., Budahazi,G., Sisson,W., Villafranca,J.E., Janson,C.A., McElroy,H.E., Gribskov,C.L. and Worland,S.
    Structure of human rhinovirus 3C protease reveals a trypsin-like polypeptide fold, RNA-binding site, and means for cleaving precursor polyprotein
    Cell77, 761-771. PubMed  Europe PubMed DOI  S
    13. 1990
  13. Neill,J.D.
    Nucleotide sequence of a region of the feline calicivirus genome which encodes picornavirus-like RNA-dependent RNA polymerase, cysteine protease and 2C polypeptides
    Virus Res17, 145-160. PubMed  Europe PubMed DOI
  14. Palmenberg,A.C.
    Proteolytic processing of picornaviral polyprotein
    Annu Rev Microbiol44, 603-623. PubMed  Europe PubMed DOI
    15. 1989
  15. [YEAR:30-1-1989]Gorbalenya,A.E., Donchenko,A.P., Blinov,V.M. and Koonin,E.V.
    Cysteine proteases of positive strand RNA viruses and chymotrypsin-like serine proteases. A distinct protein superfamily with a common structural fold
    FEBS Lett243, 103-114. PubMed  Europe PubMed DOI
    16. 1988
  16. Bazan,J.F. and Fletterick,R.J.
    Viral cysteine proteases are homologous to the trypsin-like family of serine proteases: structural and functional implications
    Proc Natl Acad Sci U S A85, 7872-7876. PubMed  Europe PubMed
    17. 1984
  17. [YEAR:25-9-1984]Argos,P., Kamer,G., Nicklin,M.J. and Wimmer,E.
    Similarity in gene organization and homology between proteins of animal picornaviruses and a plant comovirus suggest common ancestry of these virus families
    Nucleic Acids Res12, 7251-7267. PubMed  Europe PubMed

feedback
Page created 8-September-2023

EMBL-EBI logo

© 2025 EBI
Terms of use