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Literature for peptidase C03.007: human rhinovirus 2-type picornain 3C

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

(Topics flags: S Structure, T Target, P Specificity, I Inhibitor, E Expression, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2026
  1. Ashok,Y., Bubb,K.L., Oy,C., Gorjifard,S., Cuperus,J.T., Queitsch,C. and Fields,S.<br>Dosa: A method to covalently barcode proteins for high-throughput biochemistry<br>Proc Natl Acad Sci U S A (2026) 123, e2529762123-e2529762123. PubMed  Europe PubMed DOI  PMC  EPMC
  2. Lee,J., Lee,H.L., Kim,H., Gil,Y., Lee,S.H., Jung,Y.S., Shin,J.S. and Jo,I.<br>Structural insights into the antiviral efficacy of AG7404 against human rhinovirus 3C proteases<br>IUCrJ (2026) PubMed  Europe PubMed DOI  I
    3. 2025
  3. Zhang,S., Zong,K., Ruan,J., Liu,X., Zhao,X., Zhang,Y., Hu,C. and Li,X.<br>Discovery of non-covalent rhinovirus 3Cpro inhibitors by molecular docking, in vitro assays, molecular dynamics simulations and DFT analyses<br>Front Pharmacol (2025) 16, 1560571-1560571. PubMed  Europe PubMed DOI  PMC  EPMC  I
    4. 2024
  4. Mei,M., Fan,X., Zhou,Y., Zhang,F., Zhang,G. and Yi,L.<br>A combinatorial strategy for HRV 3C protease engineering to achieve the N-terminal free cleavage<br>Int J Biol Macromol (2024) 265, 131066-131066. PubMed  Europe PubMed DOI
  5. Tarumoto,S., Inoue,S., Yanagimoto,R. and Saitoh,T.<br>Monitoring of enzymatic cleavage reaction of GST-fusion protein on biolayer interferometry sensor<br>Biophys Physicobiol (2024) 21, e210019-e210019. PubMed  Europe PubMed DOI  PMC  EPMC
    6. 2023
  6. Lin,T., Ge,Y., Gao,Q., Zhang,D., Chen,X., Hu,Y. and Fan,J.<br>Backbone Cyclization of Flavin Mononucleotide-Based Fluorescent Protein Increases Fluorescence and Stability<br>J Microbiol Biotechnol (2023) 33, 1681-1691. PubMed  Europe PubMed DOI  PMC  EPMC
    7. 2021
  7. Abdelkader,E.H. and Otting,G.<br>NT*-HRV3CP: An optimized construct of human rhinovirus 14 3C protease for high-yield expression and fast affinity-tag cleavage<br>J Biotechnol (2021) 325, 145-151. PubMed  Europe PubMed DOI
  8. Liu,C., Boland,S., Scholle,M.D., Bardiot,D., Marchand,A., Chaltin,P., Blatt,L.M., Beigelman,L., Symons,J.A., Raboisson,P., Gurard-Levin,Z.A., VanDyck,K. and Deval,J.<br>Dual inhibition of SARS-CoV-2 and human rhinovirus with protease inhibitors in clinical development<br>Antiviral Res (2021) 187, 105020-105020. PubMed  Europe PubMed DOI  PMC  EPMC  I
    9. 2020
  9. Fan,X., Li,X., Zhou,Y., Mei,M., Liu,P., Zhao,J., Peng,W., Jiang,Z.B., Yang,S., Iverson,B.L., Zhang,G. and Yi,L.<br>Quantitative analysis of the substrate specificity of human rhinovirus 3C protease and exploration of its substrate recognition mechanisms<br>ACS Chem Biol (2020) 15, 63-73. PubMed  Europe PubMed DOI  P
  10. Smart,D., Filippi,I., Blume,C., Smalley,B., Davies,D. and McCormick,C.J.<br>Rhinovirus 2A is the key protease responsible for instigating the early block to gene expression in infected cells<br>J Cell Sci (2020) 133, jcs232504-jcs232504. PubMed  Europe PubMed DOI
    11. 2019
  11. Kassem,A.F., Batran,R.Z., Abbas,E.M.H., Elseginy,S.A., Shaheen,M.N.F. and Elmahdy,E.M.<br>New 4-phenylcoumarin derivatives as potent 3C protease inhibitors: design, synthesis, anti-HAV effect and molecular modeling<br>Eur J Med Chem (2019) 168, 447-460. PubMed  Europe PubMed DOI  I
  12. Xu,H., Wang,Q., Zhang,Z., Yi,L., Ma,L. and Zhai,C.<br>A simplified method to remove fusion tags from a xylanase of Bacillus sp. HBP8 with HRV 3C protease<br>Enzyme Microb Technol (2019) 123, 15-20. PubMed  Europe PubMed DOI
    13. 2018
  13. Croft,S.N., Walker,E.J. and Ghildyal,R.<br>Human rhinovirus 3C protease cleaves RIPK1, concurrent with caspase 8 activation<br>Sci Rep (2018) 8, 1569-1569. PubMed  Europe PubMed DOI  PMC  EPMC
  14. Lotzerich,M., Roulin,P.S., Boucke,K., Witte,R., Georgiev,O. and Greber,U.F.<br>Rhinovirus 3C protease suppresses apoptosis and triggers caspase-independent cell death<br>Cell Death Dis (2018) 9, 272-272. PubMed  Europe PubMed DOI
    15. 2016
  15. Kawatkar,S.P., Gagnon,M., Hoesch,V., Tiong-Yip,C., Johnson,K., Ek,M., Nilsson,E., Lister,T., Olsson,L., Patel,J. and Yu,Q.<br>Design and structure-activity relationships of novel inhibitors of human rhinovirus 3C protease<br>Bioorg Med Chem Lett (2016) 26, 3248-3252. PubMed  Europe PubMed DOI  S  I
    16. 2015
  16. Jensen,L.M., Walker,E.J. and Ghildyal,R.<br>A protocol to express and isolate HRV16 3C protease for use in protease assays<br>Methods Mol Biol (2015) 1221, 143-148. PubMed  Europe PubMed DOI  E
  17. Jensen,L.M., Walker,E.J., Jans,D.A. and Ghildyal,R.<br>Proteases of human rhinovirus: role in infection<br>Methods Mol Biol (2015) 1221, 129-141. PubMed  Europe PubMed DOI  V
    18. 2014
  18. Feng,Y., Xu,Q., Yang,T., Sun,E., Li,J., Shi,D. and Wu,D.<br>A novel self-cleavage system for production of soluble recombinant protein in Escherichia coli<br>Protein Expr Purif (2014) 99, 64-69. PubMed  Europe PubMed DOI
    19. 2013
  19. Raran-Kurussi,S., Tozser,J., Cherry,S., Tropea,J.E. and Waugh,D.S.<br>Differential temperature dependence of tobacco etch virus and rhinovirus 3C proteases<br>Anal Biochem (2013) 436, 142-144. PubMed  Europe PubMed DOI
  20. Walker,E.J., Younessi,P., Fulcher,A.J., McCuaig,R., Thomas,B.J., Bardin,P.G., Jans,D.A. and Ghildyal,R.<br>Rhinovirus 3C protease facilitates specific nucleoporin cleavage and mislocalisation of nuclear proteins in infected host cells<br>PLoS ONE (2013) 8, e71316-e71316. PubMed  Europe PubMed DOI  PMC  EPMC
    21. 2012
  21. Wishart,D.S.<br>Picornain 3C (human rhinovirus)<br>[ISSN:978-0-12-407743-0] (2012) 3, 2402-2406. DOI
    22. 2011
  22. Baxter,A., Chambers,M., Edfeldt,F., Edman,K., Freeman,A., Johansson,C., King,S., Morley,A., Petersen,J., Rawlins,P., Spadola,L., Thong,B., Poel,H.V. and Williams,N.<br>Non-covalent inhibitors of rhinovirus 3C protease<br>Bioorg Med Chem Lett (2011) 21, 777-780. PubMed  Europe PubMed DOI  I
    23. 2009
  23. Barral,P.M., Sarkar,D., Fisher,P.B. and Racaniello,V.R.<br>RIG-I is cleaved during picornavirus infection<br>Virology (2009) 391, 171-176. PubMed  Europe PubMed DOI  PMC  EPMC
  24. Ghildyal,R., Jordan,B., Li,D., Dagher,H., Bardin,P.G., Gern,J.E. and Jans,D.A.<br>Rhinovirus 3C protease can localize in the nucleus and alter active and passive nucleocytoplasmic transport<br>J Virol (2009) 83, 7349-7352. PubMed  Europe PubMed DOI  PMC  EPMC
  25. Im,I., Lee,E.S., Choi,S.J., Lee,J.Y. and Kim,Y.C.<br>Structure-activity relationships of heteroaromatic esters as human rhinovirus 3C protease inhibitors<br>Bioorg Med Chem Lett (2009) 19, 3632-3636. PubMed  Europe PubMed DOI  I
    26. 2008
  26. de Breyne,S., Bonderoff,J.M., Chumakov,K.M., Lloyd,R.E. and Hellen,C.U.<br>Cleavage of eukaryotic initiation factor eIF5B by enterovirus 3C proteases<br>Virology (2008) 378, 118-122. PubMed  Europe PubMed DOI  PMC  EPMC
    27. 2007
  27. Lao,X.Z. and Wu,W.T.<br>Structure-based design of human rhinovirus 3C protease inhibitors<br>Yao Wu Sheng Wu Ji Shu (2007) 14, 218-220.  I
  28. Wanga,Q.M. and Chen,S.H.<br>Human rhinovirus 3C protease as a potential target for the development of antiviral agents<br>Curr Protein Pept Sci (2007) 8, 19-27. PubMed  Europe PubMed DOI  V  T
    29. 2005
  29. Binford,S.L., Maldonado,F., Brothers,M.A., Weady,P.T., Zalman,L.S., Meador,J.W., III, Matthews,D.A. and Patick,A.K.<br>Conservation of amino acids in human rhinovirus 3C protease correlates with broad-spectrum antiviral activity of rupintrivir, a novel human rhinovirus 3C protease inhibitor<br>Antimicrob Agents Chemother (2005) 49, 619-626. PubMed  Europe PubMed DOI  PMC  EPMC  I
  30. Patick,A.K., Brothers,M.A., Maldonado,F., Binford,S., Maldonado,O., Fuhrman,S., Petersen,A., Smith,G.J., III, Zalman,L.S., Burns-Naas,L.A. and Tran,J.Q.<br>In vitro antiviral activity and single-dose pharmacokinetics in humans of a novel, orally bioavailable inhibitor of human rhinovirus 3C protease<br>Antimicrob Agents Chemother (2005) 49, 2267-2275. PubMed  Europe PubMed DOI  PMC  EPMC  I
    31. 2004
  31. Amineva,S.P., Aminev,A.G., Palmenberg,A.C. and Gern,J.E.<br>Rhinovirus 3C protease precursors 3CD and 3CD' localize to the nuclei of infected cells<br>J Gen Virol (2004) 85, 2969-2979. PubMed  Europe PubMed DOI
  32. [YEAR:6-11-2004]Funkhouser,A.W., Kang,J.A., Tan,A., Li,J., Zhou,L., Abe,M.K., Solway,J. and Hershenson,M.B.<br>Rhinovirus 16 3C protease induces interleukin-8 and granulocyte-macrophage colony-stimulating factor expression in human bronchial epithelial cells<br>Pediatr Res (6-11-2004) 55, 13-18. PubMed  Europe PubMed DOI
  33. Lall,M.S., Jain,R.P. and Vederas,J.C.<br>Inhibitors of 3C cysteine proteinases from Picornaviridae<br>Curr Top Med Chem (2004) 4, 1239-1253. PubMed  Europe PubMed DOI  I
  34. Skern,T.<br>Picornain 3C<br>[ISSN:0-12-079610-4] (2004) 2, 1353-1357.  V
  35. Wang,Q.M.<br>Picornain 3C (human rhinovirus)<br>[ISSN:0-12-079610-4] (2004) 2, 1358-1361.  V
    36. 2003
  36. [YEAR:20-10-2003]Chen,S.H., Lamar,J., Victor,F., Snyder,N., Johnson,R., Heinz,B.A., Wakulchik,M. and Wang,Q.M.<br>Synthesis and evaluation of tripeptidyl alpha-ketoamides as human rhinovirus 3C protease inhibitors<br>Bioorg Med Chem Lett (20-10-2003) 13, 3531-3536. PubMed  Europe PubMed DOI  I
  37. [YEAR:9-10-2003]Dragovich,P.S., Prins,T.J., Zhou,R., Johnson,T.O., Hua,Y., Luu,H.T., Sakata,S.K., Brown,E.L., Maldonado,F.C., Tuntland,T., Lee,C.A., Fuhrman,S.A., Zalman,L.S., Patick,A.K., Matthews,D.A., Wu,E.Y., Guo,M., Borer,B.C., Nayyar,N.K., Moran,T., Chen,L., Rejto,P.A., Rose,P.W., Guzman,M.C., Dovalsantos,E.Z., Lee,S., McGee,K., Mohajeri,M., Liese,A., Tao,J., Kosa,M.B., Liu,B., Batugo,M.R., Gleeson,J.P., Wu,Z.P., Liu,J., Meador,J.W., III and Ferre,R.A.<br>Structure-based design, synthesis, and biological evaluation of irreversible human rhinovirus 3C protease inhibitors. 8. Pharmacological optimization of orally bioavailable 2-pyridone-containing peptidomimetics<br>J Med Chem (9-10-2003) 46, 4572-4585. PubMed  Europe PubMed DOI  I
    38. 2002
  38. [YEAR:11-4-2002]Dragovich,P.S., Prins,T.J., Zhou,R., Brown,E.L., Maldonado,F.C., Fuhrman,S.A., Zalman,L.S., Tuntland,T., Lee,C.A., Patick,A.K., Matthews,D.A., Hendrickson,T.F., Kosa,M.B., Liu,B., Batugo,M.R., Gleeson,J.P., Sakata,S.K., Chen,L., Guzman,M.C., Meador,J.W., III, Ferre,R.A. and Worland,S.T.<br>Structure-based design, synthesis, and biological evaluation of irreversible human rhinovirus 3C protease inhibitors. 6. Structure-activity studies of orally bioavailable, 2-pyridone-containing peptidomimetics<br>J Med Chem (11-4-2002) 45, 1607-1623. PubMed  Europe PubMed DOI  S  I
  39. [YEAR:11-3-2002]Dragovich,P.S., Prins,T.J., Zhou,R., Johnson,T.O., Brown,E.L., Maldonado,F.C., Fuhrman,S.A., Zalman,L.S., Patick,A.K., Matthews,D.A., Hou,X., Meador,J.W., Ferre,R.A. and Worland,S.T.<br>Structure-based design, synthesis, and biological evaluation of irreversible human rhinovirus 3C protease inhibitors. Part 7: Structure-activity studies of bicyclic 2-pyridone-containing peptidomimetics<br>Bioorg Med Chem Lett (11-3-2002) 12, 733-738. PubMed  Europe PubMed DOI  I
    40. 2001
  40. [YEAR:24-9-2001]Tian,Q.P., Nayyar,N.K., Babu,S., Chen,L.J., Tao,J.H., Lee,S., Tibbetts,A., Moran,T., Liou,J., Guo,M. and Kennedy,T.P.<br>An efficient synthesis of a key intermediate for the preparation of the rhinovirus protease inhibitor AG7088 via asymmetric dianionic cyanomethylation of N-Boc-L-(+)-glutamic acid dimethyl ester<br>Tetrahedron Lett (24-9-2001) 42, 6807-6809.  I
  41. [YEAR:22-10-2001]Webber,S.E., Marakovits,J.T., Dragovich,P.S., Prins,T.J., Zhou,R., Fuhrman,S.A., Patick,A.K., Matthews,D.A., Lee,C.A., Srinivasan,B., Moran,T., Ford,C.E., Brothers,M.A., Harr,J.E., Meador,J.W., III, Ferre,R.A. and Worland,S.T.<br>Design and synthesis of irreversible depsipeptidyl human rhinovirus 3C protease inhibitors<br>Bioorg Med Chem Lett (22-10-2001) 11, 2683-2686. PubMed  Europe PubMed DOI  I
  42. Zhang,K.E., Hee,B., Lee,C.A., Liang,B. and Potts,B.C.<br>Liquid chromatography-mass spectrometry and liquid chromatography-NMR characterization of in vitro metabolites of a potent and irreversible peptidomimetic inhibitor of rhinovirus 3C protease<br>Drug Metab Dispos (2001) 29, 729-734. PubMed  Europe PubMed  I
    43. 2000
  43. [YEAR:3-1-2000]Dragovich,P.S., Zhou,R., Webber,S.E., Prins,T.J., Kwok,A.K., Okano,K., Fuhrman,S.A., Zalman,L.S., Maldonado,F.C., Brown,E.L., Meador,J.W., III, Patick,A.K., Ford,C.E., Brothers,M.A., Binford,S.L., Matthews,D.A., Ferre,R.A. and Worland,S.T.<br>Structure-based design of ketone-containing, tripeptidyl human rhinovirus 3C protease inhibitors<br>Bioorg Med Chem Lett (3-1-2000) 10, 45-48. PubMed  Europe PubMed DOI  I
  44. Zalman,L.S., Brothers,M.A., Dragovich,P.S., Zhou,R., Prins,T.J., Worland,S.T. and Patick,A.K.<br>Inhibition of human rhinovirus-induced cytokine production by AG7088, a human rhinovirus 3C protease inhibitor<br>Antimicrobial Agents Chemother (2000) 44, 1236-1241. PubMed  Europe PubMed DOI  PMC  EPMC  I
    45. 1999
  45. [YEAR:8-4-1999]Dragovich,P.S., Prins,T.J., Zhou,R., Fuhrman,S.A., Patick,A.K., Matthews,D.A., Ford,C.E., Meador,J.W., III, Ferre,R.A. and Worland,S.T.<br>Structure-based design, synthesis, and biological evaluation of irreversible human rhinovirus 3C protease inhibitors. 3. Structure-activity studies of ketomethylene-containing peptidomimetics<br>J Med Chem (8-4-1999) 42, 1203-1212. PubMed  Europe PubMed DOI  I
  46. Dragovich,P.S., Zhou,R., Skalitzky,D.J., Fuhrman,S.A., Patick,A.K., Ford,C.E., Meador,J.W., III and Worland,S.T.<br>Solid-phase synthesis of irreversible human rhinovirus 3C protease inhibitors. Part 1: Optimization of tripeptides incorporating N-terminal amides<br>Bioorg Med Chem (1999) 7, 589-598. PubMed  Europe PubMed DOI  I
  47. [YEAR:24-12-1999]Hill,R.D. and Vederas,J.C.<br>Azodicarboxamides: a new class of cysteine proteinase inhibitor for hepatitis A virus and human rhinovirus 3C enzymes<br>J Org Chem (24-12-1999) 64, 9538-9546.  I
  48. [YEAR:15-2-1999]Kati,W.M., Sham,H.L., McCall,J.O., Montgomery,D.A., Wang,G.T., Rosenbrook,W., Miesbauer,L., Buko,A. and Norbeck,D.W.<br>Inhibition of 3C protease from human rhinovirus strain 1B by peptidyl bromomethylketonehydrazides<br>Arch Biochem Biophys (15-2-1999) 362, 363-375. PubMed  Europe PubMed DOI  I
  49. [YEAR:28-9-1999]Matthews,D.A., Dragovich,P.S., Webber,S.E., Fuhrman,S.A., Patick,A.K., Zalman,L.S., Hendrickson,T.F., Love,R.A., Prins,T.J., Marakovits,J.T., Zhou,R., Tikhe,J., Ford,C.E., Meador,J.W., Ferre,R.A., Brown,E.L., Binford,S.L., Brothers,M.A., DeLisle,D.M. and Worland,S.T.<br>Structure-assisted design of mechanism-based irreversible inhibitors of human rhinovirus 3C protease with potent antiviral activity against multiple rhinovirus serotypes<br>Proc Natl Acad Sci U S A (28-9-1999) 96, 11000-11007. PubMed  Europe PubMed DOI  PMC  EPMC  I
  50. Patick,A.K., Binford,S.L., Brothers,M.A., Jackson,R.L., Ford,C.E., Diem,M.D., Maldonado,F., Dragovich,P.S., Zhou,R., Prins,T.J., Fuhrman,S.A., Meador,J.W., Zalman,L.S., Matthews,D.A. and Worland,S.T.<br>In vitro antiviral activity of AG7088, a potent inhibitor of human rhinovirus 3C protease<br>Antimicrobial Agents Chemother (1999) 43, 2444-2450. PubMed  Europe PubMed  PMC  EPMC  I
  51. Wang,Q.M.<br>Protease inhibitors as potential antiviral agents for the treatment of picornaviral infections<br>Prog Drug Res (1999) 52, 197-219. PubMed  Europe PubMed  T
    52. 1998
  52. [YEAR:16-7-1998]Dragovich,P.S., Webber,S.E., Babine,R.E., Fuhrman,S.A., Patick,A.K., Matthews,D.A., Reich,S.H., Marakovits,J.T., Prins,T.J., Zhou,R., Tikhe,J., Littlefield,E.S., Bleckman,T.M., Wallace,M.B., Little,T.L., Ford,C.E., Meador,J.W., III, Ferre,R.A., Brown,E.L., Binford,S.L., DeLisle,D.M. and Worland,S.T.<br>Structure-based design, synthesis, and biological evaluation of irreversible human rhinovirus 3C protease inhibitors. 2. Peptide structure-activity studies<br>J Med Chem (16-7-1998) 41, 2819-2834. PubMed  Europe PubMed DOI  I
  53. [YEAR:2-7-1998]Kong,J.S., Venkatraman,S., Furness,K., Nimkar,S., Shepherd,T.A., Wang,Q.M., Aube,J. and Hanzlik,R.P.<br>Synthesis and evaluation of peptidyl Michael acceptors that inactivate human rhinovirus 3C protease and inhibit virus replication<br>J Med Chem (2-7-1998) 41, 2579-2587. PubMed  Europe PubMed DOI  I
    54. 1997
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    55. 1996
  55. Heinz,B.A., Tang,J., Labus,J.M., Chadwell,F.W., Kaldor,S.W. and Hammond,M.<br>Simple in vitro translation assay to analyze inhibitors of rhinovirus proteases<br>Antimicrobial Agents Chemother (1996) 40, 267-270. PubMed  Europe PubMed  PMC  EPMC
    56. 1995
  56. Sham,H.L., Rosenbrook,W., Kati,W., Betebenner,D.A., Wideburg,N.E., Saldivar,A., Plattner,J.J. and Norbeck,D.W.<br>Potent inhibitor of the human rhinovirus (HRV) 3C protease containing a backbone modified glutamine<br>Chem Soc J [Perkin 1] (1995) 1, 1081-1082.  I
    57. 1994
  57. Matthews,D.A., Smith,W.W., Ferre,R.A., Condon,B., Budahazi,G., Sisson,W., Villafranca,J.E., Janson,C.A., McElroy,H.E., Gribskov,C.L. and Worland,S.<br>Structure of human rhinovirus 3C protease reveals a trypsin-like polypeptide fold, RNA-binding site, and means for cleaving precursor polyprotein<br>Cell (1994) 77, 761-771. PubMed  Europe PubMed DOI  S
    58. 1992
  58. Leong,L.E.C., Walker,P.A. and Porter,A.G.<br>Efficient expression and purification of a protease from the common cold virus, human rhinovirus type-14<br>J Cryst Growth (1992) 122, 246-252.  E
    59. 1991
  59. Hopkins,J.L., Betageri,R., Cohen,K.A., Emmanuel,M.J., Joseph,C.R., Bax,P.M., Pallai,P.V. and Skoog,M.T.<br>Rhinovirus 3C protease catalyzes efficient cleavage of a fluorescein-labeled peptide affording a rapid and robust assay<br>J Biochem Biophys Methods (1991) 23, 107-113. PubMed  Europe PubMed DOI  P
  60. Singh,S.B., Cordingley,M.G., Ball,R.G., Smith,J.L., Dombrowski,A.W. and Goetz,M.A.<br>Structure and stereochemistry of thysanone: a novel human rhinovirus 3C-protease inhibitor from Thysanophora penicilloides<br>Tetrahedron Lett (1991) 32, 5279-5282. DOI  I
    61. 1990
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    62. 1989
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