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Literature for peptidase C03.005: hepatitis A virus-type picornain 3C

Summary Alignment Sequences Sequence features Distribution Structure Literature Substrates

(Topics flags: S Structure, A Assay, T Target, P Specificity, K Knockout, E Expression, V Review, I Inhibitor, U Therapeutic. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Huang,H.E., Colasanti,O., Li,T.F. and Lohmann,V.<br>Limited impact of hepatitis A virus 3C protease-mediated cleavage on the functions of NEMO in human hepatocytes<br>J Virol (2025) , e0226424-e0226424. PubMed  Europe PubMed DOI  K
    2. 2024
  2. Karaseva,M.A., Gramma,V.A., Safina,D.R., Lunina,N.A., Komissarov,A.A., Kostrov,S.V. and Demidyuk,I.V.<br>Expression and Purification of His-Tagged Variants of Human Hepatitis A Virus 3C Protease<br>Protein Pept Lett (2024) 31, 305-311-311. PubMed  Europe PubMed DOI
  3. Sureshan,M., Brintha,S. and Jothi,A.<br>Identification of Mulberrofuran as a potent inhibitor of hepatitis A virus 3C(pro) and RdRP enzymes through structure-based virtual screening, dynamics simulation, and DFT studies<br>Mol Divers (2024) 28, 1609-1628. PubMed  Europe PubMed DOI  I
    4. 2023
  4. Sun,L., Feng,H., Misumi,I., Shirasaki,T., Hensley,L., Gonzalez-Lopez,O., Shiota,I., Chou,W.C., Ting,J.P., Cullen,J.M., Cowley,D.O., Whitmire,J.K. and Lemon,S.M.<br>Viral protease cleavage of MAVS in genetically modified mice with hepatitis A virus infection<br>J Hepatol (2023) 78, 271-280. PubMed  Europe PubMed DOI
    5. 2021
  5. Komissarov,A.A., Karaseva,M.A., Roschina,M.P., Shubin,A.V., Lunina,N.A., Kostrov,S.V. and Demidyuk,I.V.<br>Individual Expression of Hepatitis A Virus 3C Protease Induces Ferroptosis in Human Cells In Vitro<br>Int J Mol Sci (2021) 22 PubMed  Europe PubMed DOI  PMC  EPMC
  6. Selina,P.I., Karaseva,M.A., Komissarov,A.A., Safina,D.R., Lunina,N.A., Roschina,M.P., Sverdlov,E.D., Demidyuk,I.V. and Kostrov,S.V.<br>Embryotoxic activity of 3C protease of human hepatitis A virus in developing Danio rerio embryos<br>Sci Rep (2021) 11, 18196-18196. PubMed  Europe PubMed DOI  PMC  EPMC
    7. 2019
  7. Al-Salahi,R., Anouar,E.H., Marzouk,M. and Abuelizz,H.A.<br>Anti-HAV evaluation and molecular docking of newly synthesized 3-benzyl(phenethyl)benzo[g]quinazolines<br>Bioorg Med Chem Lett (2019) 29, 1614-1619. PubMed  Europe PubMed DOI  I
  8. Banerjee,K., Bhat,R., Rao,V.U.B., Nain,A., Rallapalli,K.L., Gangopadhyay,S., Singh,R.P., Banerjee,M. and Jayaram,B.<br>Toward development of generic inhibitors against the 3C proteases of picornaviruses<br>FEBS J (2019) 286, 765-787. PubMed  Europe PubMed DOI  I
  9. Kassem,A.F., Batran,R.Z., Abbas,E.M.H., Elseginy,S.A., Shaheen,M.N.F. and Elmahdy,E.M.<br>New 4-phenylcoumarin derivatives as potent 3C protease inhibitors: design, synthesis, anti-HAV effect and molecular modeling<br>Eur J Med Chem (2019) 168, 447-460. PubMed  Europe PubMed DOI  I
    10. 2017
  10. Sun,D., Wang,M., Wen,X., Cheng,A., Jia,R., Sun,K., Yang,Q., Wu,Y., Zhu,D., Chen,S., Liu,M., Zhao,X. and Chen,X.<br>Cleavage of poly(A)-binding protein by duck hepatitis A virus 3C protease<br>Sci Rep (2017) 7, 16261-16261. PubMed  Europe PubMed DOI  PMC  EPMC
  11. Zhou,J., Wang,D., Xi,Y., Zhu,X., Yang,Y., Lv,M., Luo,C., Chen,J., Ye,X., Fang,L. and Xiao,S.<br>Assessing activity of hepatitis A virus 3C protease using a cyclized luciferase-based biosensor<br>Biochem Biophys Res Commun (2017) 488, 621-627. PubMed  Europe PubMed DOI  A
    12. 2015
  12. Shubin,A.V., Demidyuk,I.V., Lunina,N.A., Komissarov,A.A., Roschina,M.P., Leonova,O.G. and Kostrov,S.V.<br>Protease 3C of hepatitis A virus induces vacuolization of lysosomal/endosomal organelles and caspase-independent cell death<br>BMC Cell Biol (2015) 16, 4- PubMed  Europe PubMed DOI  PMC  EPMC
    13. 2014
  13. Wang,D., Fang,L., Wei,D., Zhang,H., Luo,R., Chen,H., Li,K. and Xiao,S.<br>Hepatitis A virus 3C protease cleaves NEMO to impair induction of beta interferon<br>J Virol (2014) 88, 10252-10258. PubMed  Europe PubMed DOI
    14. 2012
  14. Blaum,B.S., Wunsche,W., Benie,A.J., Kusov,Y., Peters,H., Gauss-Muller,V., Peters,T. and Sczakiel,G.<br>Functional binding of hexanucleotides to 3C protease of hepatitis A virus<br>Nucleic Acids Res (2012) 40, 3042-3055. PubMed  Europe PubMed DOI  I
  15. Yin,J. and Bergmann,E.M.<br>Hepatitis A virus picornain 3C<br>[ISSN:978-0-12-407743-0] (2012) 3, 2417-2423. DOI
    16. 2011
  16. Qu,L., Feng,Z., Yamane,D., Liang,Y., Lanford,R.E., Li,K. and Lemon,S.M.<br>Disruption of TLR3 signaling due to cleavage of TRIF by the hepatitis A virus protease-polymerase processing intermediate, 3CD<br>PLoS Pathog (2011) 7, e1002169-e1002169. PubMed  Europe PubMed DOI  PMC  EPMC
  17. Sellamuthu,S., Shin,B.H., Han,H.E., Park,S.M., Oh,H.J., Rho,S.H., Lee,Y.J. and Park,W.J.<br>An engineered viral protease exhibiting substrate specificity for a polyglutamine stretch prevents polyglutamine-induced neuronal cell death<br>PLoS ONE (2011) 6, e22554-e22554. PubMed  Europe PubMed DOI  PMC  EPMC  U
    18. 2010
  18. Kanda,T., Gauss-Muller,V., Cordes,S., Tamura,R., Okitsu,K., Shuang,W., Nakamoto,S., Fujiwara,K., Imazeki,F. and Yokosuka,O.<br>Hepatitis A virus (HAV) proteinase 3C inhibits HAV IRES-dependent translation and cleaves the polypyrimidine tract-binding protein<br>J Viral Hepat (2010) 17, 618-623. PubMed  Europe PubMed DOI
    19. 2008
  19. Huitema,C., Zhang,J., Yin,J., James,M.N., Vederas,J.C. and Eltis,L.D.<br>Heteroaromatic ester inhibitors of hepatitis A virus 3C proteinase: evaluation of mode of action<br>Bioorg Med Chem (2008) 16, 5761-5777. PubMed  Europe PubMed DOI  T  I
  20. Sellamuthu,S., Shin,B.H., Lee,E.S., Rho,S.H., Hwang,W., Lee,Y.J., Han,H.E., Kim,J.I. and Park,W.J.<br>Engineering of protease variants exhibiting altered substrate specificity<br>Biochem Biophys Res Commun (2008) 371, 122-126. PubMed  Europe PubMed DOI  P
  21. Sperry,J. and Brimble,M.A.<br>An efficient enantioselective synthesis of the 3C protease inhibitor (-)-thysanone<br>Synlett (2008) 2008, 1910-1912. DOI  I
    22. 2007
  22. Yang,Y., Liang,Y., Qu,L., Chen,Z., Yi,M., Li,K. and Lemon,S.M.<br>Disruption of innate immunity due to mitochondrial targeting of a picornaviral protease precursor<br>Proc Natl Acad Sci U S A (2007) 104, 7253-7258. PubMed  Europe PubMed DOI  PMC  EPMC
  23. Zhang,B., Seitz,S., Kusov,Y., Zell,R. and Gauss-Muller,V.<br>RNA interaction and cleavage of poly(C)-binding protein 2 by hepatitis A virus protease<br>Biochem Biophys Res Commun (2007) 364, 725-730. PubMed  Europe PubMed DOI
  24. Zhang,B., Morace,G., Gauss-Muller,V. and Kusov,Y.<br>Poly(A) binding protein, C-terminally truncated by the hepatitis A virus proteinase 3C, inhibits viral translation<br>Nucleic Acids Res (2007) 35, 5975-5984. PubMed  Europe PubMed DOI  PMC  EPMC
    25. 2006
  25. James,M.N.<br>The peptidases from fungi and viruses<br>Biol Chem (2006) 387, 1023-1029. PubMed  Europe PubMed DOI  S
  26. [YEAR:7-7-2006]Yin,J., Cherney,M.M., Bergmann,E.M., Zhang,J., Huitema,C., Pettersson,H., Eltis,L.D., Vederas,J.C. and James,M.N.<br>An episulfide cation (thiiranium ring) trapped in the active site of HAV 3C proteinase inactivated by peptide-based ketone inhibitors<br>J Mol Biol (7-7-2006) 361, 673-686. PubMed  Europe PubMed DOI  S  I
    27. 2005
  27. [YEAR:13-9-2005]Peters,H., Kusov,Y.Y., Meyer,S., Benie,A.J., Bauml,E., Wolff,M., Rademacher,C., Peters,T. and Gauss-Muller,V.<br>Hepatitis A virus proteinase 3C binding to viral RNA: correlation with substrate binding and enzyme dimerization<br>Biochem J (13-9-2005) 385, 363-370. PubMed  Europe PubMed DOI  PMC  EPMC
  28. [YEAR:14-10-2005]Yin,J., Bergmann,E.M., Cherney,M.M., Lall,M.S., Jain,R.P., Vederas,J.C. and James,M.N.<br>Dual modes of modification of hepatitis A virus 3C protease by a serine-derived beta-lactone: selective crystallization and formation of a functional catalytic triad in the active site<br>J Mol Biol (14-10-2005) 354, 854-871. PubMed  Europe PubMed DOI  S  I
    29. 2004
  29. Bergmann,E.M.<br>Hepatitis A virus picornain 3C<br>[ISSN:0-12-079610-4] (2004) 2, 1373-1376.  V
  30. [YEAR:16-7-2004]Jain,R.P. and Vederas,J.C.<br>Structural variations in keto-glutamines for improved inhibition against hepatitis A virus 3C proteinase<br>Bioorg Med Chem Lett (16-7-2004) 14, 3655-3658. PubMed  Europe PubMed DOI
  31. Lall,M.S., Jain,R.P. and Vederas,J.C.<br>Inhibitors of 3C cysteine proteinases from Picornaviridae<br>Curr Top Med Chem (2004) 4, 1239-1253. PubMed  Europe PubMed DOI  I
  32. Skern,T.<br>Picornain 3C<br>[ISSN:0-12-079610-4] (2004) 2, 1353-1357.  V
    33. 2002
  33. Cohen,L., Benichou,D. and Martin,A.<br>Analysis of deletion mutants indicates that the 2A polypeptide of hepatitis A virus participates in virion morphogenesis<br>J Virol (2002) 76, 7495-7505. PubMed  Europe PubMed DOI  PMC  EPMC
  34. [YEAR:8-3-2002]Lall,M.S., Ramtohul,Y.K., James,M.N. and Vederas,J.C.<br>Serine and threonine beta-lactones: a new class of hepatitis a virus 3C cysteine proteinase inhibitors<br>J Org Chem (8-3-2002) 67, 1536-1547. PubMed  Europe PubMed DOI  I
  35. Ramtohul,Y.K., Martin,N.I., Silkin,L., James,M.N.G. and Vederas,J.C.<br>Synthesis of pseudoxazolones and their inhibition of the 3C cysteine proteinases from hepatitis A virus and human rhinovirus-14<br>J Chem Soc [Perkin 1] (2002) 2002, 1351-1359.
  36. [YEAR:17-5-2002]Ramtohul,Y.K., James,M.N. and Vederas,J.C.<br>Synthesis and evaluation of keto-glutamine analogues as inhibitors of hepatitis A virus 3C proteinase<br>J Org Chem (17-5-2002) 67, 3169-3178. PubMed  Europe PubMed DOI  I
    37. 2001
  37. [YEAR:6-4-2001]Kabrane-Lazizi,Y., Emerson,S.U., Herzog,C. and Purcell,R.H.<br>Detection of antibodies to HAV 3C proteinase in experimentally infected chimpanzees and in naturally infected children<br>Vaccine (6-4-2001) 19, 2878-2883. PubMed  Europe PubMed DOI
    38. 1999
  38. [YEAR:5-12-1999]Bergmann,E.M., Cherney,M.M., Mckendrick,J., Frormann,S., Luo,C., Malcolm,B.A., Vederas,J.C. and James,M.N.<br>Crystal structure of an inhibitor complex of the 3C proteinase from hepatitis A virus (HAV) and implications for the polyprotein processing in HAV<br>Virology (5-12-1999) 265, 153-163. PubMed  Europe PubMed DOI  S  I
  39. Huang,Y., Malcolm,B.A. and Vederas,J.C.<br>Synthesis and testing of azaglutamine derivatives as inhibitors of hepatitis A virus (HAV) 3C proteinase<br>Bioorg Med Chem (1999) 7, 607-619. PubMed  Europe PubMed DOI  I
  40. Kusov,Y. and Gauss-Muller,V.<br>Improving proteolytic cleavage at the 3A/3B site of the hepatitis A virus polyprotein impairs processing and particle formation, and the impairment can be complemented in trans by 3AB and 3ABC<br>J Virol (1999) 73, 9867-9878. PubMed  Europe PubMed  PMC  EPMC
  41. Seipelt,J., Guarne,A., Bergmann,E., James,M., Sommergruber,W., Fita,I. and Skern,T.<br>The structures of picornaviral proteinases<br>Virus Res (1999) 62, 159-168. PubMed  Europe PubMed DOI
    42. 1997
  42. Bergmann,E.M., Mosimann,S.C., Chernaia,M.M., Malcolm,B.A. and James,M.N.<br>The refined crystal structure of the 3C gene product from hepatitis A virus: specific proteinase activity and RNA recognition<br>J Virol (1997) 71, 2436-2448. PubMed  Europe PubMed  PMC  EPMC  S
  43. Gosert,R., Dollenmaier,G. and Weitz,M.<br>Identification of active-site residues in protease 3C of hepatitis A virus by site-directed mutagenesis<br>J Virol (1997) 71, 3062-3068. PubMed  Europe PubMed  PMC  EPMC
  44. Morris,T.S., Frormann,S., Shechosky,S., Lowe,C., Lall,M.S., Gauss-Muller,V., Purcell,R.H., Emerson,S.U., Vederas,J.C. and Malcolm,B.A.<br>In vitro and ex vivo inhibition of hepatitis A virus 3C proteinase by a peptidyl monofluoromethyl ketone<br>Bioorg Med Chem (1997) 5, 797-807. PubMed  Europe PubMed DOI  I
  45. Ryan,M.D. and Flint,M.<br>Virus-encoded proteinases of the picornavirus super-group<br>J Gen Virol (1997) 78, 699-723. PubMed  Europe PubMed
    46. 1996
  46. Gosert,R., Cassinotti,P., Siegl,G. and Weitz,M.<br>Identification of hepatitis A virus non-structural protein 2B and its release by the major virus protease 3C<br>J Gen Virol (1996) 77, 247-255. PubMed  Europe PubMed
    47. 1995
  47. Malcolm,B.A., Lowe,C., Shechosky,S., McKay,R.T., Yang,C.C., Shah,V.J., Simon,R.J., Vederas,J.C. and Santi,D.V.<br>Peptide aldehyde inhibitors of hepatitis A virus 3C proteinase<br>Biochemistry (1995) 34, 8172-8179. PubMed  Europe PubMed DOI  I
  48. [YEAR:20-10-1995]Martin,A., Escriou,N., Chao,S.F., Girard,M., Lemon,S.M. and Wychowski,C.<br>Identification and site-directed mutagenesis of the primary (2A/2B) cleavage site of the hepatitis A virus polyprotein: functional impact on the infectivity of HAV RNA transcripts<br>Virology (20-10-1995) 213, 213-222. PubMed  Europe PubMed DOI
  49. Schultheiss,T., Sommergruber,W., Kusov,Y. and Gauss-Muller,V.<br>Cleavage specificity of purified recombinant hepatitis A virus 3C proteinase on natural substrates<br>J Virol (1995) 69, 1727-1733. PubMed  Europe PubMed  PMC  EPMC  P
    50. 1994
  50. Allaire,M. and James,M.<br>Deduction of the 3C proteinases' fold<br>Nat Struct Biol (1994) 1, 505-506. PubMed  Europe PubMed  S
  51. [YEAR:5-5-1994]Allaire,M., Chernaia,M.M., Malcolm,B.A. and James,M.N.<br>Picornaviral 3C cysteine proteinases have a fold similar to chymotrypsin-like serine proteinases<br>Nature (5-5-1994) 369, 72-76. PubMed  Europe PubMed DOI  S
  52. Schultheiss,T., Kusov,Y.Y. and Gauss-Muller,V.<br>Proteinase 3C of hepatitis A virus (HAV) cleaves the HAV polyprotein P2-P3 at all sites including VP1/2a and 2a/2b<br>Virology (1994) 198, 275-281. PubMed  Europe PubMed
  53. Tesar,M., Pak,I., Jia,X.Y., Richards,O.C., Summers,D.F. and Ehrenfeld,E.<br>Expression of hepatitis A virus precursor protein P3 in vivo and in vitro: polyprotein processing of the 3CD cleavage site<br>Virology (1994) 198, 524-533. PubMed  Europe PubMed DOI
    54. 1993
  54. Chernaia,M.M., Malcolm,B.A., Allaire,M. and James,M.N.<br>Hepatitis A virus 3C proteinase: some properties, crystallization and preliminary crystallographic characterization<br>J Mol Biol (1993) 234, 890-893. PubMed  Europe PubMed DOI
  55. Jia,X.Y., Summers,D.F. and Ehrenfeld,E.<br>Primary cleavage of the HAV capsid protein precursor in the middle of the proposed 2A coding region<br>Virology (1993) 193, 515-519. PubMed  Europe PubMed DOI
    56. 1992
  56. Harmon,S.A., Updike,W., Jia,X.Y., Summers,D.F. and Ehrenfeld,E.<br>Polyprotein processing in cis and in trans by hepatitis A virus 3C protease cloned and expressed in Escherichia coli<br>J Virol (1992) 66, 5242-5247. PubMed  Europe PubMed  PMC  EPMC
  57. Jewell,D.A., Swietnicki,W., Dunn,B.M. and Malcolm,B.A.<br>Hepatitis A virus 3C proteinase substrate specificity<br>Biochemistry (1992) 31, 7862-7869. PubMed  Europe PubMed  P
  58. Kusov,Y.Y., Sommergruber,W., Schreiber,M. and Gauss-Muller,V.<br>Intermolecular cleavage of hepatitis A virus (HAV) precursor protein P1-P2 by recombinant HAV proteinase 3C<br>J Virol (1992) 66, 6794-6796. PubMed  Europe PubMed  PMC  EPMC
  59. Malcolm,B.A., Chin,S.M., Jewell,D.A., Stratton-Thomas,J.R., Thudium,K.B., Ralston,R. and Rosenberg,S.<br>Expression and characterization of recombinant hepatitis A virus 3C proteinase<br>Biochemistry (1992) 31, 3358-3363. PubMed  Europe PubMed DOI  E
    60. 1991
  60. Gauss-Muller,V., Jurgensen,D. and Deutzmann,R.<br>Autoproteolytic cleavage of recombinant 3C proteinase of hepatitis A virus<br>Virology (1991) 182, 861-864. PubMed  Europe PubMed DOI
  61. Jia,X.Y., Ehrenfeld,E. and Summers,D.F.<br>Proteolytic activity of hepatitis A virus 3C protein<br>J Virol (1991) 65, 2595-2600. PubMed  Europe PubMed  PMC  EPMC
    62. 1988
  62. Krausslich,H.G. and Wimmer,E.<br>Viral proteinases<br>Annu Rev Biochem (1988) 57, 701-754. PubMed  Europe PubMed DOI
    63. 1984
  63. Blinov,V.M., Gorbalenia,A.E. and Donchenko,A.P.<br>[Structural similarity of poliovirus cysteine proteinase P3-7c and cellular serine proteinase of trypsin]<br>Dokl Akad Nauk SSSR (1984) 279, 502-505. PubMed  Europe PubMed

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