Merops Switch to
Inhibitors

Peptidase

Family Clan SEARCHES BLAST
MEROPS SUBMISSIONS

Other
information

Literature for peptidase C01.076: CPA peptidase

Summary Alignment Tree Sequences Sequence features Distribution Literature Substrates

(Topics flags: T Target, K Knockout, I Inhibitor, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2018
  1. Martinez-Garcia,S., Rodriguez-Martinez,S., Cancino-Diaz,M.E. and Cancino-Diaz,J.C.
    Extracellular proteases of Staphylococcus epidermidis: roles as virulence factors and their participation in biofilm
    APMIS126, 177-185. PubMed  Europe PubMed DOI
    2. 2017
  2. Beyzay,F., Zavaran Hosseini,A. and Soudi,S.
    Alpha alumina nanoparticle conjugation to cysteine peptidase A and B: an efficient method for autophagy induction
    Avicenna J Med Biotechnol9, 71-81. PubMed  Europe PubMed
    3. 2015
  3. Shahbazi,M., Zahedifard,F., Taheri,T., Taslimi,Y., Jamshidi,S., Shirian,S., Mahdavi,N., Hassankhani,M., Daneshbod,Y., Zarkesh-Esfahani,S.H., Papadopoulou,B. and Rafati,S.
    Evaluation of live recombinant nonpathogenic Leishmania tarentolae expressing cysteine proteinase and A2 Genes as a candidate vaccine against experimental canine visceral leishmaniasis
    PLoS ONE10, e0132794-e0132794. PubMed  Europe PubMed DOI
    4. 2014
  4. Ferreira,J.H., Silva,L.S., Longo-Maugeri,I.M., Katz,S. and Barbieri,C.L.
    Use of a recombinant cysteine proteinase from Leishmania (Leishmania) infantum chagasi for the immunotherapy of canine visceral leishmaniasis
    PLoS Negl Trop Dis8, e2729-e2729. PubMed  Europe PubMed DOI
    5. 2012
  5. Myburgh,E., Coombs,G.H. and Mottram,J.C.
    Leishmania CPA, CPB and CPC cysteine proteases
    [ISSN:978-0-12-407743-0]3, 1923-1928. DOI
  6. Rana,S., Dikhit,M.R., Rani,M., Moharana,K.C., Sahoo,G.C. and Das,P.
    CPDB: cysteine protease annotation database in Leishmania species
    Integr Biol (Camb)4, 1351-1357. PubMed  Europe PubMed DOI
    7. 2011
  7. Caffrey,C.R., Lima,A.P. and Steverding,D.
    Cysteine peptidases of kinetoplastid parasites
    Adv Exp Med Biol712, 84-99. PubMed  Europe PubMed DOI  V
  8. Doroud,D., Zahedifard,F., Vatanara,A., Najafabadi,A.R., Taslimi,Y., Vahabpour,R., Torkashvand,F., Vaziri,B. and Rafati,S.
    Delivery of a cocktail DNA vaccine encoding cysteine proteinases type I, II and III with solid lipid nanoparticles potentiate protective immunity against Leishmania major infection
    J Control Release153, 154-162. PubMed  Europe PubMed DOI
    9. 2010
  9. Fedeli,C.E., Ferreira,J.H., Mussalem,J.S., Longo-Maugeri,I.M., Gentil,L.G., dos Santos,M.R., Katz,S. and Barbieri,C.L.
    Partial protective responses induced by a recombinant cysteine proteinase from Leishmania (Leishmania) amazonensis in a murine model of cutaneous leishmaniasis
    Exp Parasitol124, 153-158. PubMed  Europe PubMed DOI
    10. 2009
  10. Caffrey,C.R. and Steverding,D.
    Kinetoplastid papain-like cysteine peptidases
    Mol Biochem Parasitol167, 12-19. PubMed  Europe PubMed DOI  I
  11. Pinheiro,P.H., Pinheiro,A.N., Ferreira,J.H., Costa,F.A., Katz,S. and Barbieri,C.L.
    A recombinant cysteine proteinase from Leishmania (Leishmania) chagasi as an antigen for delayed-type hypersensitivity assays and serodiagnosis of canine visceral leishmaniasis
    Vet Parasitol162, 32-39. PubMed  Europe PubMed DOI
  12. Saffari,B. and Mohabatkar,H.
    Computational analysis of cysteine proteases (Clan CA, Family C1) of Leishmania major to find potential epitopic regions
    Genomics Proteomics Bioinformatics7, 87-95. PubMed  Europe PubMed DOI
    13. 2008
  13. Ferreira,J.H., Gentil,L.G., Dias,S.S., Fedeli,C.E., Katz,S. and Barbieri,C.L.
    Immunization with the cysteine proteinase Ldccys1 gene from Leishmania (Leishmania) chagasi and the recombinant Ldccys1 protein elicits protective immune responses in a murine model of visceral leishmaniasis
    Vaccine26, 677-685. PubMed  Europe PubMed DOI
    14. 2007
  14. Kuru,T., Jirata,D., Genetu,A., Barr,S., Mengistu,Y., Aseffa,A. and Gedamu,L.
    Leishmania aethiopica: identification and characterization of cathepsin L-like cysteine protease genes
    Exp Parasitol115, 283-290. PubMed  Europe PubMed DOI
    15. 2006
  15. Denise,H., Poot,J., Jimenez,M., Ambit,A., Herrmann,D.C., Vermeulen,A.N., Coombs,G.H. and Mottram,J.C.
    Studies on the CPA cysteine peptidase in the Leishmania infantum genome strain JPCM5
    BMC Mol Biol7, 42-42. PubMed  Europe PubMed DOI
  16. [YEAR:7-11-2006]Hu,K.J. and Leung,P.C.
    Complete, precise, and innocuous loss of multiple introns in the currently intronless, active cathepsin L-like genes, and inference from this event
    Mol Phylogenet Evol38, 685-696. PubMed  Europe PubMed DOI
  17. [YEAR:27-6-2006]Williams,R.A., Tetley,L., Mottram,J.C. and Coombs,G.H.
    Cysteine peptidases CPA and CPB are vital for autophagy and differentiation in Leishmania mexicana
    Mol Microbiol61, 655-674. PubMed  Europe PubMed DOI  T
    18. 2004
  18. Mottram,J.C., Coombs,G.H. and Alexander,J.
    Cysteine peptidases as virulence factors of Leishmania
    Curr Opin Microbiol7, 375-381. PubMed  Europe PubMed DOI
  19. Mottram,J.C. and Coombs,G.H.
    Leishmania CPA, CPB and CPC cysteine proteases
    [ISSN:0-12-079610-4]2, 1166-1169.  V
  20. [YEAR:7-5-2004]Zadeh-Vakili,A., Taheri,T., Taslimi,Y., Doustdari,F., Salmanian,A.H. and Rafati,S.
    Immunization with the hybrid protein vaccine, consisting of Leishmania major cysteine proteinases Type I (CPB) and Type II (CPA), partially protects against leishmaniasis
    Vaccine22, 1930-1940. PubMed  Europe PubMed DOI
    21. 2003
  21. Chibale,K. and Musonda,C.C.
    The synthesis of parasitic cysteine protease and trypanothione reductase inhibitors
    Curr Med Chem10, 1863-1889. PubMed  Europe PubMed DOI  I
  22. Lasakosvitsch,F., Gentil,L.G., dos Santos,M.R., da Silveira,J.F. and Barbieri,C.L.
    Cloning and characterisation of a cysteine proteinase gene expressed in amastigotes of Leishmania (L.) amazonensis
    Int J Parasitol33, 445-454. PubMed  Europe PubMed DOI
  23. Pascalis,H., Lavergne,A., Bourreau,E., Prevot-Linguet,G., Kariminia,A., Pradinaud,R., Rafati,S. and Launois,P.
    Th1 cell development induced by cysteine proteinases A and B in localized cutaneous leishmaniasis due to Leishmania guyanensis
    Infect Immun71, 2924-2926. PubMed  Europe PubMed DOI
  24. Rafati,S., Nakhaee,A., Taheri,T., Ghashghaii,A., Salmanian,A.H., Jimenez,M., Mohebali,M., Masina,S. and Fasel,N.
    Expression of cysteine proteinase type I and II of Leishmania infantum and their recognition by sera during canine and human visceral leishmaniasis
    Exp Parasitol103, 143-151. PubMed  Europe PubMed DOI
    25. 2002
  25. Sajid,M. and McKerrow,J.H.
    Cysteine proteases of parasitic organisms
    Mol Biochem Parasitol120, 1-21. PubMed  Europe PubMed
    26. 2001
  26. [YEAR:14-5-2001]Rafati,S., Salmanian,A.H., Taheri,T., Vafa,M. and Fasel,N.
    A protective cocktail vaccine against murine cutaneous leishmaniasis with DNA encoding cysteine proteinases of Leishmania major
    Vaccine19, 3369-3375. PubMed  Europe PubMed DOI
  27. Rafati,S., Salmanian,A.H., Hashemi,K., Schaff,C., Belli,S. and Fasel,N.
    Identification of Leishmania major cysteine proteinases as targets of the immune response in humans
    Mol Biochem Parasitol113, 35-43. PubMed  Europe PubMed DOI
    28. 2000
  28. Brooks,D.R., Tetley,L., Coombs,G.H. and Mottram,J.C.
    Processing and trafficking of cysteine proteases in Leishmania mexicana
    J Cell Sci113, 4035-4041. PubMed  Europe PubMed  K
    29. 1998
  29. [YEAR:15-12-1998]Alexander,J., Coombs,G.H. and Mottram,J.C.
    Leishmania mexicana cysteine proteinase-deficient mutants have attenuated virulence for mice and potentiate a TH1 response
    J Immunol161, 6794-6801. PubMed  Europe PubMed  K
  30. Mottram,J.C., Brooks,D.R. and Coombs,G.H.
    Roles of cysteine proteinases of trypanosomes and Leishmania in host-parasite interactions
    Curr Opin Microbiol1, 455-460. PubMed  Europe PubMed
    31. 1997
  31. [YEAR:1-12-1997]Omara-Opyene,A.L. and Gedamu,L.
    Molecular cloning, characterization and overexpression of two distinct cysteine protease cDNAs from Leishmania donovani chagasi
    Mol Biochem Parasitol90, 247-267. PubMed  Europe PubMed DOI
    32. 1994
  32. Duboise,S.M., Vannier-Santos,M.A., Costa-Pinto,D., Rivas,L., Pan,A.A., Traub-Cseko,Y., de Souza,W. and McMahon-Pratt,D.
    The biosynthesis, processing, and immunolocalization of Leishmania pifanoi amastigote cysteine proteinases
    Mol Biochem Parasitol68, 119-132. PubMed  Europe PubMed DOI
  33. Robertson,C.D. and Coombs,G.H.
    Multiple high activity cysteine proteases of Leishmania mexicana are encoded by the Imcpb gene array
    Microbiology (Reading, Engl )140, 417-424. PubMed  Europe PubMed
  34. Souza,A.E., Bates,P.A., Coombs,G.H. and Mottram,J.C.
    Null mutants for the lmcpa cysteine proteinase gene in Leishmania mexicana
    Mol Biochem Parasitol63, 213-220. PubMed  Europe PubMed DOI  K
    35. 1993
  35. Traub-Cseko,Y.M., Duboise,M., Boukai,L.K. and McMahon-Pratt,D.
    Identification of two distinct cysteine proteinase genes of Leishmania pifanoi axenic amastigotes using the polymerase chain reaction
    Mol Biochem Parasitol57, 101-115. PubMed  Europe PubMed DOI
    36. 1992
  36. Mottram,J.C., Robertson,C.D., Coombs,G.H. and Barry,J.D.
    A developmentally regulated cysteine proteinase gene of Leishmania mexicana
    Mol Microbiol6, 1925-1932. PubMed  Europe PubMed DOI
    37. 1990
  37. Robertson,C.D. and Coombs,G.H.
    Characterisation of three groups of cysteine proteinases in the amastigotes of Leishmania mexicana mexicana
    Mol Biochem Parasitol42, 269-276. PubMed  Europe PubMed DOI

feedback
Page created 8-September-2023

EMBL-EBI logo

© 2025 EBI
Terms of use