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Literature for peptidase C01.046: falcipain-2

Summary Alignment Sequences Sequence features Distribution Structure Literature Substrates Pharma

(Topics flags: S Structure, T Target, K Knockout, P Specificity, I Inhibitor, E Expression, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2024
  1. Di Chio,C., Starvaggi,J., Totaro,N., Previti,S., Natale,B., Cosconati,S., Bogacz,M., Schirmeister,T., Legac,J., Rosenthal,P.J., Zappala,M. and Ettari,R.
    Development of Novel Peptidyl Nitriles Targeting Rhodesain and Falcipain-2 for the Treatment of Sleeping Sickness and Malaria
    Int J Mol Sci25, PubMed  Europe PubMed DOI  I
  2. Hernandez Gonzalez,J.E., Salas-Sarduy,E., Alvarez,L.H., Valiente,P.A., Arni,R.K. and Pascutti,P.G.
    Three decades targeting falcipains to develop antiplasmodial agents: what have we learned and what can be done next?
    Curr Med Chem31, 2234-2263. PubMed  Europe PubMed DOI
  3. Madhav,H., Reddy,G.S., Rizvi,Z., Jameel,E., Patel,T.S., Rahman,A., Yadav,V., Fatima,S., Heyat,F., Pal,K., Minju-Op,A., Subbarao,N., Bhattacharjee,S., Dixit,B.C., Sijwali,P.S. and Hoda,N.
    Reinvestigation of diphenylmethylpiperazine analogues of pyrazine as new class of Plasmodial cysteine protease inhibitors for the treatment of malaria
    RSC Med Chem15, 1022-1037. PubMed  Europe PubMed DOI  I
    4. 2023
  4. Patra,J., Rana,D., Arora,S., Pal,M. and Mahindroo,N.
    Falcipains: Biochemistry, target validation and structure-activity relationship studies of inhibitors as antimalarials
    Eur J Med Chem252, 115299-115299. PubMed  Europe PubMed DOI
    5. 2022
  5. Chakraborty,S., Alam,B. and Biswas,S.
    New insights of falcipain 2 structure from Plasmodium falciparum 3D7 strain
    Biochem Biophys Res Commun590, 145-151. PubMed  Europe PubMed DOI
  6. Hernandez Gonzalez,J.E., Alberca,L.N., Masforrol Gonzalez,Y., Reyes Acosta,O., Talevi,A. and Salas-Sarduy,E.
    Tetracycline Derivatives Inhibit Plasmodial Cysteine Protease Falcipain-2 through Binding to a Distal Allosteric Site
    J Chem Inf Model62, 159-175. PubMed  Europe PubMed DOI
  7. Le,H.G., Kang,J.M., Vo,T.C., Yoo,W.G., Lee,K.H. and Na,B.K.
    Biochemical Properties of Two Plasmodium malariae Cysteine Proteases, Malapain-2 and Malapain-4
    Microorganisms10, PubMed  Europe PubMed DOI
    8. 2021
  8. Aratikatla,E.K., Kalamuddin,M., Rana,K.C., Datta,G., Asad,M., Sundararaman,S., Malhotra,P., Mohmmed,A. and Bhattacharya,A.K.
    Combating multi-drug resistant malaria parasite by inhibiting falcipain-2 and heme-polymerization: Artemisinin-peptidyl vinyl phosphonate hybrid molecules as new antimalarials
    Eur J Med Chem220, 113454-113454. PubMed  Europe PubMed DOI
    9. 2020
  9. Aratikatla,E.K., Kalamuddin,M., Malhotra,P., Mohmmed,A. and Bhattacharya,A.K.
    Enantioselective Synthesis of gamma-Phenyl-gamma-amino Vinyl Phosphonates and Sulfones and Their Application to the Synthesis of Novel Highly Potent Antimalarials
    ACS Omega5, 29025-29037. PubMed  Europe PubMed DOI  I
  10. Ettari,R., Previti,S., Di Chio,C. and Zappala,M.
    Falcipain-2 and falcipain-3 inhibitors as promising antimalarial agents
    Curr Med Chem PubMed  Europe PubMed DOI  V
  11. Hernandez Gonzalez,J.E., Hernandez Alvarez,L., Leite,V.B.P. and Pascutti,P.G.
    Water Bridges Play a Key Role in Affinity and Selectivity for Malarial Protease Falcipain-2
    J Chem Inf Model PubMed  Europe PubMed DOI  T
  12. Kumar,A., Kumar,D., Kumar,R., Singh,P., Chandra,R. and Kumari,K.
    DFT and docking studies of designed conjugates of noscapines & repurposing drugs: promising inhibitors of main protease of SARS-CoV-2 and falcipan-2
    J Biomol Struct Dyn1-21. PubMed  Europe PubMed DOI
  13. Mishra,M., Singh,V., Tellis,M.B., Joshi,R.S., Pandey,K.C. and Singh,S.
    Cyclic peptide engineered from phytocystatin inhibitory hairpin loop as an effective modulator of falcipains and potent antimalarial
    J Biomol Struct Dyn1-13. PubMed  Europe PubMed DOI
  14. Rajguru,T., Bora,D. and Modi,M.K.
    Combined CADD and Virtual Screening to Identify Novel Nonpeptidic Falcipain-2 Inhibitors
    Curr Comput Aided Drug Des PubMed  Europe PubMed DOI
  15. Rosenthal,P.J.
    Falcipain cysteine proteases of malaria parasites: an update
    Biochim Biophys Acta Proteins Proteom1868, 140362-140362. PubMed  Europe PubMed DOI
  16. Singh,A., Kalamuddin,M., Maqbool,M., Mohmmed,A., Malhotra,P. and Hoda,N.
    Quinoline carboxamide core moiety-based compounds inhibit P. falciparumfalcipain-2: Design, synthesis and antimalarial efficacy studies
    Bioorg Chem104514-104514. PubMed  Europe PubMed DOI  I
  17. Singh,V., Hada,R.S., Uddin,A., Aneja,B., Abid,M., Pandey,K.C. and Singh,S.
    Inhibition of hemoglobin degrading protease falcipain-2 as a mechanism for anti-malarial activity of triazole-amino acid hybrids
    Curr Top Med Chem20, 377-389. PubMed  Europe PubMed DOI  I
  18. Uddin,A., Singh,V., Irfan,I., Mohammad,T., Singh Hada,R., Imtaiyaz Hassan,M., Abid,M. and Singh,S.
    Identification and structure-activity relationship (SAR) studies of carvacrol derivatives as potential anti-malarial against Plasmodium falciparum falcipain-2 protease
    Bioorg Chem103, 104142-104142. PubMed  Europe PubMed DOI
  19. Zhu,L., Shan,L., Zhu,J., Li,L., Li,S., Wang,L., Wang,J., Zhang,S., Zhou,H., Zhang,W. and Li,H.
    Discovery of a natural fluorescent probe targeting the Plasmodium falciparum cysteine protease falcipain-2
    Sci China Life Sci63, 1016-1025. PubMed  Europe PubMed DOI
    20. 2019
  20. Alam,B. and Biswas,S.
    Inhibition of Plasmodium falciparum cysteine protease falcipain-2 by a human cross-class inhibitor serpinB3: a mechanistic insight
    Biochim Biophys Acta Proteins Proteom1867, 854-865. PubMed  Europe PubMed DOI
  21. Alberca,L.N., Chuguransky,S.R., Alvarez,C.L., Talevi,A. and Salas-Sarduy,E.
    In silico guided drug repurposing: discovery of new competitive and non-competitive inhibitors of falcipain-2
    Front Chem7, 534-534. PubMed  Europe PubMed DOI  I
  22. Allangba,K.N.P.G., Keita,M., Kre N'Guessan,R., Megnassan,E., Frecer,V. and Miertus,S.
    Virtual design of novel Plasmodium falciparum cysteine protease falcipain-2 hybrid lactone-chalcone and isatin-chalcone inhibitors probing the S2 active site pocket
    J Enzyme Inhib Med Chem34, 547-561. PubMed  Europe PubMed DOI  I
  23. Cianni,L., Feldmann,C.W., Gilberg,E., Gutschow,M., Juliano,L., Leitao,A., Bajorath,J. and Montanari,C.A.
    Can cysteine protease cross-class inhibitors achieve selectivity?
    J Med Chem62, 10497-10525. PubMed  Europe PubMed DOI  I
  24. Hernandez Gonzalez,J.E., Hernandez Alvarez,L., Pascutti,P.G. and Leite,V.B.P.
    Prediction of noncompetitive inhibitor binding mode reveals promising site for allosteric modulation of falcipain-2
    J Phys Chem B123, 7327-7342. PubMed  Europe PubMed DOI  I
  25. Machin,J.M., Kantsadi,A.L. and Vakonakis,I.
    The complex of Plasmodium falciparum falcipain-2 protease with an (E)-chalcone-based inhibitor highlights a novel, small, molecule-binding site
    Malar J18, 388-388. PubMed  Europe PubMed DOI  I
  26. Musyoka,T.M., Njuguna,J.N. and Tastan Bishop,O.
    Comparing sequence and structure of falcipains and human homologs at prodomain and catalytic active site for malarial peptide based inhibitor design
    Malar J18, 159-159. PubMed  Europe PubMed DOI
  27. Pasupureddy,R., Verma,S., Pant,A., Sharma,R., Seshadri,S., Pande,V., Saxena,A.K., Dixit,R. and Pandey,K.C.
    Crucial residues in falcipains that mediate hemoglobin hydrolysis
    Exp Parasitol197, 43-50. PubMed  Europe PubMed DOI
  28. Rana,D., Kalamuddin,M., Sundriyal,S., Jaiswal,V., Sharma,G., Das Sarma,K., Sijwali,P.S., Mohmmed,A., Malhotra,P. and Mahindroo,N.
    Identification of antimalarial leads with dual falcipain-2 and falcipain-3 inhibitory activity
    Bioorg Med Chem115155-115155. PubMed  Europe PubMed DOI  I
  29. Stoye,A., Juillard,A., Tang,A.H., Legac,J., Gut,J., White,K.L., Charman,S.A., Rosenthal,P.J., Grau,G.E.R., Hunt,N.H. and Payne,R.J.
    Falcipain inhibitors based on the natural product gallinamide A are potent in vitro and in vivo antimalarials
    J Med Chem62, 5562-5578. PubMed  Europe PubMed DOI  I
    30. 2018
  30. Aggarwal,S., Paliwal,D., Kaushik,D., Gupta,G.K. and Kumar,A.
    Pyrazole Schiff base hybrids as anti-malarial agents: synthesis, in vitro screening and computational study
    Comb Chem High Throughput Screen21, 194-203. PubMed  Europe PubMed DOI  I
  31. Bekono,B.D., Ntie-Kang,F., Owono Owono,L.C. and Megnassan,E.
    Targeting cysteine proteases from Plasmodium falciparum: a general overview, rational drug design and computational approaches for drug discovery
    Curr Drug Targets19, 501-526. PubMed  Europe PubMed DOI  I
  32. Hernandez-Gonzalez,J.E., Salas-Sarduy,E., Hernandez Ramirez,L.F., Pascual,M.J., Alvarez,D.E., Pabon,A., Leite,V.B.P., Pascutti,P.G. and Valiente,P.A.
    Identification of (4-(9H-fluoren-9-yl) piperazin-1-yl) methanone derivatives as falcipain 2 inhibitors active against Plasmodium falciparum cultures
    Biochim Biophys Acta Gen Subj1862, 2911-2923. PubMed  Europe PubMed DOI  I
  33. Himangini, Pathak,D.P., Sharma,V. and Kumar,S.
    Designing novel inhibitors against falcipain-2 of Plasmodium falciparum
    Bioorg Med Chem Lett28, 1566-1569. PubMed  Europe PubMed DOI  I
  34. Nizi,E., Sferrazza,A., Fabbrini,D., Nardi,V., Andreini,M., Graziani,R., Gennari,N., Bresciani,A., Paonessa,G. and Harper,S.
    Peptidomimetic nitrile inhibitors of malarial protease falcipain-2 with high selectivity against human cathepsins
    Bioorg Med Chem Lett28, 1540-1544. PubMed  Europe PubMed DOI  I
  35. Pant,A., Kumar,R., Wani,N.A., Verma,S., Sharma,R., Pande,V., Saxena,A.K., Dixit,R., Rai,R. and Pandey,K.C.
    Allosteric site inhibitor disrupting auto-processing of malarial cysteine proteases
    Sci Rep8, 16193-16193. PubMed  Europe PubMed DOI
  36. Royo,S., Schirmeister,T., Kaiser,M., Jung,S., Rodriguez,S., Bautista,J.M. and Gonzalez,F.V.
    Antiprotozoal and cysteine proteases inhibitory activity of dipeptidyl enoates
    Bioorg Med Chem26, 4624-4634. PubMed  Europe PubMed DOI  I
  37. Salawu,E.O.
    In silico study reveals how E64 approaches, binds to, and inhibits falcipain-2 of Plasmodium falciparum that causes malaria in humans
    Sci Rep8, 16380-16380. PubMed  Europe PubMed DOI  I
  38. Siddiqui,F.A., Cabrera,M., Wang,M., Brashear,A., Kemirembe,K., Wang,Z., Miao,J., Chookajorn,T., Yang,Z., Cao,Y., Dong,G., Rosenthal,P.J. and Cui,L.
    Plasmodium falciparum falcipain-2a polymorphisms in southeast Asia and their association with artemisinin resistance
    J Infect Dis218, 434-442. PubMed  Europe PubMed DOI
    39. 2017
  39. Chen,W., Huang,Z., Wang,W., Mao,F., Guan,L., Tang,Y., Jiang,H., Li,J., Huang,J., Jiang,L. and Zhu,J.
    Discovery of new antimalarial agents: second-generation dual inhibitors against FP-2 and PfDHFR via fragments assembely
    Bioorg Med Chem25, 6467-6478. PubMed  Europe PubMed DOI  I
  40. Hernandez Gonzalez,J.E., Hernandez Alvarez,L., Pascutti,P.G. and Valiente,P.A.
    Predicting binding modes of reversible peptide-based inhibitors of falcipain-2 consistent with structure-activity relationships
    Proteins85, 1666-1683. PubMed  Europe PubMed DOI  I
  41. Previti,S., Ettari,R., Cosconati,S., Amendola,G., Chouchene,K., Wagner,A., Hellmich,U.A., Ulrich,K., Krauth-Siegel,R.L., Wich,P.R., Schmid,I., Schirmeister,T., Gut,J., Rosenthal,P.J., Grasso,S. and Zappala,M.
    Development of novel peptide-based Michael acceptors targeting rhodesain and falcipain-2 for the treatment of neglected tropical diseases (NTDs)
    J Med Chem60, 6911-6923. PubMed  Europe PubMed DOI  I
  42. Rudrapal,M., Chetia,D. and Singh,V.
    Novel series of 1,2,4-trioxane derivatives as antimalarial agents
    J Enzyme Inhib Med Chem32, 1159-1173. PubMed  Europe PubMed DOI  I
    43. 2016
  43. Bertoldo,J.B. and Terenzi,H.
    Oxidation and tyrosine nitration induce structural changes and inhibits Plasmodium falciparum falcipain-2 activity in vitro
    Protein Pept Lett23, 562-572. PubMed  Europe PubMed
  44. Musyoka,T.M., Kanzi,A.M., Lobb,K.A. and Tastan Bishop,O.
    Structure based docking and molecular dynamic studies of plasmodial cysteine proteases against a South African natural compound and its analogs
    Sci Rep6, 23690-23690. PubMed  Europe PubMed DOI  I
  45. Musyoka,T.M., Kanzi,A.M., Lobb,K.A. and Tastan Bishop,O.
    Analysis of non-peptidic compounds as potential malarial inhibitors against plasmodial cysteine proteases via integrated virtual screening workflow
    J Biomol Struct Dyn34, 2084-2101. PubMed  Europe PubMed DOI  I
  46. Ponsuwanna,P., Kochakarn,T., Bunditvorapoom,D., Kumpornsin,K., Otto,T.D., Ridenour,C., Chotivanich,K., Wilairat,P., White,N.J., Miotto,O. and Chookajorn,T.
    Comparative genome-wide analysis and evolutionary history of haemoglobin-processing and haem detoxification enzymes in malarial parasites
    Malar J15, 51-51. PubMed  Europe PubMed DOI
  47. Poongavanam,V. and Kongsted,J.
    Binding affinity models for falcipain inhibition based on the linear interaction energy method
    J Mol Graph Model70, 236-245. PubMed  Europe PubMed DOI  I
  48. Schmidt,I., Pradel,G., Sologub,L., Golzmann,A., Ngwa,C.J., Kucharski,A., Schirmeister,T. and Holzgrabe,U.
    Bistacrine derivatives as new potent antimalarials
    Bioorg Med Chem24, 3636-3642. PubMed  Europe PubMed DOI  I
  49. Thillainayagam,M., Anbarasu,A. and Ramaiah,S.
    Comparative molecular field analysis and molecular docking studies on novel aryl chalcone derivatives against an important drug target cysteine protease in Plasmodium falciparum
    J Theor Biol403, 110-128. PubMed  Europe PubMed DOI  I
    50. 2015
  50. Bertoldo,J.B., Chiaradia-Delatorre,L.D., Mascarello,A., Leal,P.C., Cordeiro,M.N., Nunes,R.J., Sarduy,E.S., Rosenthal,P.J. and Terenzi,H.
    Synthetic compounds from an in house library as inhibitors of falcipain-2 from Plasmodium falciparum
    J Enzyme Inhib Med Chem30, 299-307. PubMed  Europe PubMed DOI  I
  51. Chakka,S.K., Kalamuddin,M., Sundararaman,S., Wei,L., Mundra,S., Mahesh,R., Malhotra,P., Mohmmed,A. and Kotra,L.P.
    Identification of novel class of falcipain-2 inhibitors as potential antimalarial agents
    Bioorg Med Chem23, 2221-2240. PubMed  Europe PubMed DOI  I
  52. Marques,A.F., Gomes,P.S., Oliveira,P.L., Rosenthal,P.J., Pascutti,P.G. and Lima,L.M.
    Allosteric regulation of the Plasmodium falciparum cysteine protease falcipain-2 by heme
    Arch Biochem Biophys573, 92-99. PubMed  Europe PubMed DOI
  53. Omotuyi,I.O. and Hamada,T.
    Dynamical footprint of falcipain-2 catalytic triad in hemoglobin-beta-bound state
    J Biomol Struct Dyn33, 1027-1036. PubMed  Europe PubMed DOI
  54. Sharma,R.K., Younis,Y., Mugumbate,G., Njoroge,M., Gut,J., Rosenthal,P.J. and Chibale,K.
    Synthesis and structure-activity-relationship studies of thiazolidinediones as antiplasmodial inhibitors of the Plasmodium falciparum cysteine protease falcipain-2
    Eur J Med Chem90C, 507-518. PubMed  Europe PubMed DOI  I
  55. Singh,A.K., Rajendran,V., Pant,A., Ghosh,P.C., Singh,N., Latha,N., Garg,S., Pandey,K.C., Singh,B.K. and Rathi,B.
    Design, synthesis and biological evaluation of functionalized phthalimides: a new class of antimalarials and inhibitors of falcipain-2, a major hemoglobinase of malaria parasite
    Bioorg Med Chem23, 1817-1827. PubMed  Europe PubMed DOI  I
    56. 2014
  56. Arafet,K., Ferrer,S., Marti,S. and Moliner,V.
    Quantum mechanics/molecular mechanics studies of the mechanism of falcipain-2 inhibition by the epoxysuccinate E64
    Biochemistry53, 3336-3346. PubMed  Europe PubMed DOI  I
  57. Conrad,M.D., Bigira,V., Kapisi,J., Muhindo,M., Kamya,M.R., Havlir,D.V., Dorsey,G. and Rosenthal,P.J.
    Polymorphisms in K13 and falcipain-2 associated with artemisinin resistance are not prevalent in Plasmodium falciparum isolated from Ugandan children
    PLoS ONE9, e105690-e105690. PubMed  Europe PubMed DOI
  58. Conroy,T., Guo,J.T., Elias,N., Cergol,K.M., Gut,J., Legac,J., Khatoon,L., Liu,Y., McGowan,S., Rosenthal,P.J., Hunt,N.H. and Payne,R.J.
    Synthesis of gallinamide A analogues as potent falcipain inhibitors and antimalarials
    J Med Chem57, 10557-10563. PubMed  Europe PubMed DOI  I
  59. Ettari,R., Pinto,A., Tamborini,L., Angelo,I.C., Grasso,S., Zappala,M., Capodicasa,N., Yzeiraj,L., Gruber,E., Aminake,M.N., Pradel,G., Schirmeister,T., De Micheli,C. and Conti,P.
    Synthesis and biological evaluation of papain-family cathepsin L-like cysteine protease inhibitors containing a 1,4-benzodiazepine scaffold as antiprotozoal agents
    ChemMedChem9, 1817-1825. PubMed  Europe PubMed DOI  I
  60. Jin,H., Xu,Z., Cui,K., Zhang,T., Lu,W. and Huang,J.
    Dietary flavonoids fisetin and myricetin: dual inhibitors of Plasmodium falciparum falcipain-2 and plasmepsin II
    Fitoterapia94, 55-61. PubMed  Europe PubMed DOI  I
  61. Omotuyi,O.I.
    Methyl-methoxylpyrrolinone and flavinium nucleus binding signatures on falcipain-2 active site
    J Mol Model20, 2386-2386. PubMed  Europe PubMed DOI  I
  62. Wang,L., Zhang,S., Zhu,J., Zhu,L., Liu,X., Shan,L., Huang,J., Zhang,W. and Li,H.
    Identification of diverse natural products as falcipain-2 inhibitors through structure-based virtual screening
    Bioorg Med Chem Lett24, 1261-1264. PubMed  Europe PubMed DOI  I
  63. Weldon,D.J., Shah,F., Chittiboyina,A.G., Sheri,A., Chada,R.R., Gut,J., Rosenthal,P.J., Shivakumar,D., Sherman,W., Desai,P., Jung,J.C. and Avery,M.A.
    Synthesis, biological evaluation, hydration site thermodynamics, and chemical reactivity analysis of alpha-keto substituted peptidomimetics for the inhibition of Plasmodium falciparum
    Bioorg Med Chem Lett24, 1274-1279. PubMed  Europe PubMed DOI  I
    64. 2013
  64. Chugh,M., Sundararaman,V., Kumar,S., Reddy,V.S., Siddiqui,W.A., Stuart,K.D. and Malhotra,P.
    Protein complex directs hemoglobin-to-hemozoin formation in Plasmodium falciparum
    Proc Natl Acad Sci U S A110, 5392-5397. PubMed  Europe PubMed DOI
  65. Cotrin,S.S., Gouvea,I.E., Melo,P.M., Bagnaresi,P., Assis,D.M., Araujo,M.S., Juliano,M.A., Gazarini,M.L., Rosenthal,P.J., Juliano,L. and Carmona,A.K.
    Substrate specificity studies of the cysteine peptidases falcipain-2 and falcipain-3 from Plasmodium falciparum and demonstration of their kininogenase activity
    Mol Biochem Parasitol187, 111-116. PubMed  Europe PubMed DOI  P
  66. Mane,U.R., Gupta,R.C., Nadkarni,S.S., Giridhar,R.R., Naik,P.P. and Yadav,M.R.
    Falcipain inhibitors as potential therapeutics for resistant strains of malaria: a patent review
    Expert Opin Ther Pat23, 165-187. PubMed  Europe PubMed DOI  V  I
  67. Marques,A.F., Esser,D., Rosenthal,P.J., Kassack,M.U. and Lima,L.M.
    Falcipain-2 inhibition by suramin and suramin analogues
    Bioorg Med Chem21, 3667-3673. PubMed  Europe PubMed DOI  I
  68. Mugumbate,G., Newton,A.S., Rosenthal,P.J., Gut,J., Moreira,R., Chibale,K. and Guedes,R.C.
    Novel anti-Plasmodial hits identified by virtual screening of the ZINC database
    J Comput Aided Mol Des27, 859-871. PubMed  Europe PubMed DOI  I
  69. Somanadhan,B., Kotturi,S.R., Yan Leong,C., Glover,R.P., Huang,Y., Flotow,H., Buss,A.D., Lear,M.J. and Butler,M.S.
    Isolation and synthesis of falcitidin, a novel myxobacterial-derived acyltetrapeptide with activity against the malaria target falcipain-2
    J Antibiot (Tokyo)66, 259-264. PubMed  Europe PubMed DOI  I
  70. Tadigoppula,N., Korthikunta,V., Gupta,S., Kancharla,P., Khaliq,T., Soni,A., Srivastava,R.K., Srivastava,K., Puri,S.K., Raju,K.S., Wahajuddin, Sijwali,P.S., Kumar,V. and Mohammad,I.S.
    Synthesis and insight into the structure-activity relationships of chalcones as antimalarial agents
    J Med Chem56, 31-45. PubMed  Europe PubMed DOI  I
  71. Wang,J., Li,Y., Yang,Y., Zhang,S. and Yang,L.
    Profiling the structural determinants of heteroarylnitrile scaffold-based derivatives as falcipain-2 inhibitors by in silico methods
    Curr Med Chem20, 2032-2042. PubMed  Europe PubMed  I
    72. 2012
  72. Bagnaresi,P., de Barros,N.M., Assis,D.M., Melo,P.M., Fonseca,R.G., Juliano,M.A., Pesquero,J.B., Juliano,L., Rosenthal,P.J., Carmona,A.K. and Gazarini,M.L.
    Intracellular proteolysis of kininogen by malaria parasites promotes release of active kinins
    Malar J11, 156-156. PubMed  Europe PubMed DOI
  73. Ettari,R., Micale,N., Grazioso,G., Bova,F., Schirmeister,T., Grasso,S. and Zappala,M.
    Synthesis and molecular modeling studies of derivatives of a highly potent peptidomimetic vinyl ester as falcipain-2 inhibitors
    ChemMedChem7, 1594-1600. PubMed  Europe PubMed DOI  I
  74. Grazioso,G., Legnani,L., Toma,L., Ettari,R., Micale,N. and De Micheli,C.
    Mechanism of falcipain-2 inhibition by alpha,beta-unsaturated benzo[1,4]diazepin-2-one methyl ester
    J Comput Aided Mol Des26, 1035-1043. PubMed  Europe PubMed DOI  I
  75. Huang,H., Lu,W., Li,X., Cong,X., Ma,H., Liu,X., Zhang,Y., Che,P., Ma,R., Li,H., Shen,X., Jiang,H., Huang,J. and Zhu,J.
    Design and synthesis of small molecular dual inhibitor of falcipain-2 and dihydrofolate reductase as antimalarial agent
    Bioorg Med Chem Lett22, 958-962. PubMed  Europe PubMed DOI  I
  76. Liu,Y., Lu,W.Q., Cui,K.Q., Luo,W., Wang,J. and Guo,C.
    Synthesis and biological activities of novel artemisinin derivatives as cysteine protease falcipain-2 inhibitors
    Arch Pharm Res35, 1525-1531. PubMed  Europe PubMed DOI  I
  77. Mane,U.R., Li,H., Huang,J., Gupta,R.C., Nadkarni,S.S., Giridhar,R., Naik,P.P. and Yadav,M.R.
    Pyrido[1,2-a]pyrimidin-4-ones as antiplasmodial falcipain-2 inhibitors
    Bioorg Med Chem20, 6296-6304. PubMed  Europe PubMed DOI  I
  78. Marco,M. and Coteron,J.M.
    Falcipain inhibition as a promising antimalarial target
    Curr Top Med Chem12, 408-444. PubMed  Europe PubMed DOI  I
  79. Pandey,K.C. and Dixit,R.
    Structure-function of falcipains: malarial cysteine proteases
    J Trop Med2012, 345195-345195. PubMed  Europe PubMed DOI  I
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    Novel cinnamic acid/4-aminoquinoline conjugates bearing non-proteinogenic amino acids: towards the development of potential dual action antimalarials
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