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Literature for peptidase C01.046: falcipain-2

Summary Alignment Sequences Sequence features Distribution Structure Literature Substrates Pharma

(Topics flags: S Structure, T Target, K Knockout, P Specificity, I Inhibitor, E Expression, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. D'Silva,S., Le,H.G., Na,B.K. and Chakraborti,S.
    Decoding substrate recognition in malapain-2 through structural and mutational insights
    Comput Struct Biotechnol J (2025) 27, 4740-4752. PubMed  Europe PubMed DOI  PMC  EPMC
    2. 2024
  2. Di Chio,C., Starvaggi,J., Totaro,N., Previti,S., Natale,B., Cosconati,S., Bogacz,M., Schirmeister,T., Legac,J., Rosenthal,P.J., Zappala,M. and Ettari,R.
    Development of Novel Peptidyl Nitriles Targeting Rhodesain and Falcipain-2 for the Treatment of Sleeping Sickness and Malaria
    Int J Mol Sci (2024) 25 PubMed  Europe PubMed DOI  PMC  EPMC  I
  3. Hernandez Gonzalez,J.E., Salas-Sarduy,E., Alvarez,L.H., Valiente,P.A., Arni,R.K. and Pascutti,P.G.
    Three decades targeting falcipains to develop antiplasmodial agents: what have we learned and what can be done next?
    Curr Med Chem (2024) 31, 2234-2263. PubMed  Europe PubMed DOI
  4. Madhav,H., Reddy,G.S., Rizvi,Z., Jameel,E., Patel,T.S., Rahman,A., Yadav,V., Fatima,S., Heyat,F., Pal,K., Minju-Op,A., Subbarao,N., Bhattacharjee,S., Dixit,B.C., Sijwali,P.S. and Hoda,N.
    Reinvestigation of diphenylmethylpiperazine analogues of pyrazine as new class of Plasmodial cysteine protease inhibitors for the treatment of malaria
    RSC Med Chem (2024) 15, 1022-1037. PubMed  Europe PubMed DOI  PMC  EPMC  I
    5. 2023
  5. Patra,J., Rana,D., Arora,S., Pal,M. and Mahindroo,N.
    Falcipains: Biochemistry, target validation and structure-activity relationship studies of inhibitors as antimalarials
    Eur J Med Chem (2023) 252, 115299-115299. PubMed  Europe PubMed DOI
    6. 2022
  6. Chakraborty,S., Alam,B. and Biswas,S.
    New insights of falcipain 2 structure from Plasmodium falciparum 3D7 strain
    Biochem Biophys Res Commun (2022) 590, 145-151. PubMed  Europe PubMed DOI
  7. Hernandez Gonzalez,J.E., Alberca,L.N., Masforrol Gonzalez,Y., Reyes Acosta,O., Talevi,A. and Salas-Sarduy,E.
    Tetracycline Derivatives Inhibit Plasmodial Cysteine Protease Falcipain-2 through Binding to a Distal Allosteric Site
    J Chem Inf Model (2022) 62, 159-175. PubMed  Europe PubMed DOI
  8. Le,H.G., Kang,J.M., Vo,T.C., Yoo,W.G., Lee,K.H. and Na,B.K.
    Biochemical Properties of Two Plasmodium malariae Cysteine Proteases, Malapain-2 and Malapain-4
    Microorganisms (2022) 10 PubMed  Europe PubMed DOI  PMC  EPMC
    9. 2021
  9. Aratikatla,E.K., Kalamuddin,M., Rana,K.C., Datta,G., Asad,M., Sundararaman,S., Malhotra,P., Mohmmed,A. and Bhattacharya,A.K.
    Combating multi-drug resistant malaria parasite by inhibiting falcipain-2 and heme-polymerization: Artemisinin-peptidyl vinyl phosphonate hybrid molecules as new antimalarials
    Eur J Med Chem (2021) 220, 113454-113454. PubMed  Europe PubMed DOI
    10. 2020
  10. Aratikatla,E.K., Kalamuddin,M., Malhotra,P., Mohmmed,A. and Bhattacharya,A.K.
    Enantioselective Synthesis of gamma-Phenyl-gamma-amino Vinyl Phosphonates and Sulfones and Their Application to the Synthesis of Novel Highly Potent Antimalarials
    ACS Omega (2020) 5, 29025-29037. PubMed  Europe PubMed DOI  PMC  EPMC  I
  11. Ettari,R., Previti,S., Di Chio,C. and Zappala,M.
    Falcipain-2 and falcipain-3 inhibitors as promising antimalarial agents
    Curr Med Chem (2020) PubMed  Europe PubMed DOI  V
  12. Hernandez Gonzalez,J.E., Hernandez Alvarez,L., Leite,V.B.P. and Pascutti,P.G.
    Water Bridges Play a Key Role in Affinity and Selectivity for Malarial Protease Falcipain-2
    J Chem Inf Model (2020) PubMed  Europe PubMed DOI  T
  13. Kumar,A., Kumar,D., Kumar,R., Singh,P., Chandra,R. and Kumari,K.
    DFT and docking studies of designed conjugates of noscapines & repurposing drugs: promising inhibitors of main protease of SARS-CoV-2 and falcipan-2
    J Biomol Struct Dyn (2020) , 1-21. PubMed  Europe PubMed DOI
  14. Mishra,M., Singh,V., Tellis,M.B., Joshi,R.S., Pandey,K.C. and Singh,S.
    Cyclic peptide engineered from phytocystatin inhibitory hairpin loop as an effective modulator of falcipains and potent antimalarial
    J Biomol Struct Dyn (2020) , 1-13. PubMed  Europe PubMed DOI
  15. Rajguru,T., Bora,D. and Modi,M.K.
    Combined CADD and Virtual Screening to Identify Novel Nonpeptidic Falcipain-2 Inhibitors
    Curr Comput Aided Drug Des (2020) PubMed  Europe PubMed DOI
  16. Rosenthal,P.J.
    Falcipain cysteine proteases of malaria parasites: an update
    Biochim Biophys Acta Proteins Proteom (2020) 1868, 140362-140362. PubMed  Europe PubMed DOI
  17. Singh,A., Kalamuddin,M., Maqbool,M., Mohmmed,A., Malhotra,P. and Hoda,N.
    Quinoline carboxamide core moiety-based compounds inhibit P. falciparumfalcipain-2: Design, synthesis and antimalarial efficacy studies
    Bioorg Chem (2020) , 104514-104514. PubMed  Europe PubMed DOI  I
  18. Singh,V., Hada,R.S., Uddin,A., Aneja,B., Abid,M., Pandey,K.C. and Singh,S.
    Inhibition of hemoglobin degrading protease falcipain-2 as a mechanism for anti-malarial activity of triazole-amino acid hybrids
    Curr Top Med Chem (2020) 20, 377-389. PubMed  Europe PubMed DOI  I
  19. Uddin,A., Singh,V., Irfan,I., Mohammad,T., Singh Hada,R., Imtaiyaz Hassan,M., Abid,M. and Singh,S.
    Identification and structure-activity relationship (SAR) studies of carvacrol derivatives as potential anti-malarial against Plasmodium falciparum falcipain-2 protease
    Bioorg Chem (2020) 103, 104142-104142. PubMed  Europe PubMed DOI
  20. Zhu,L., Shan,L., Zhu,J., Li,L., Li,S., Wang,L., Wang,J., Zhang,S., Zhou,H., Zhang,W. and Li,H.
    Discovery of a natural fluorescent probe targeting the Plasmodium falciparum cysteine protease falcipain-2
    Sci China Life Sci (2020) 63, 1016-1025. PubMed  Europe PubMed DOI
    21. 2019
  21. Alam,B. and Biswas,S.
    Inhibition of Plasmodium falciparum cysteine protease falcipain-2 by a human cross-class inhibitor serpinB3: a mechanistic insight
    Biochim Biophys Acta Proteins Proteom (2019) 1867, 854-865. PubMed  Europe PubMed DOI
  22. Alberca,L.N., Chuguransky,S.R., Alvarez,C.L., Talevi,A. and Salas-Sarduy,E.
    In silico guided drug repurposing: discovery of new competitive and non-competitive inhibitors of falcipain-2
    Front Chem (2019) 7, 534-534. PubMed  Europe PubMed DOI  PMC  EPMC  I
  23. Allangba,K.N.P.G., Keita,M., Kre N'Guessan,R., Megnassan,E., Frecer,V. and Miertus,S.
    Virtual design of novel Plasmodium falciparum cysteine protease falcipain-2 hybrid lactone-chalcone and isatin-chalcone inhibitors probing the S2 active site pocket
    J Enzyme Inhib Med Chem (2019) 34, 547-561. PubMed  Europe PubMed DOI  PMC  EPMC  I
  24. Cianni,L., Feldmann,C.W., Gilberg,E., Gutschow,M., Juliano,L., Leitao,A., Bajorath,J. and Montanari,C.A.
    Can cysteine protease cross-class inhibitors achieve selectivity?
    J Med Chem (2019) 62, 10497-10525. PubMed  Europe PubMed DOI  I
  25. Hernandez Gonzalez,J.E., Hernandez Alvarez,L., Pascutti,P.G. and Leite,V.B.P.
    Prediction of noncompetitive inhibitor binding mode reveals promising site for allosteric modulation of falcipain-2
    J Phys Chem B (2019) 123, 7327-7342. PubMed  Europe PubMed DOI  I
  26. Machin,J.M., Kantsadi,A.L. and Vakonakis,I.
    The complex of Plasmodium falciparum falcipain-2 protease with an (E)-chalcone-based inhibitor highlights a novel, small, molecule-binding site
    Malar J (2019) 18, 388-388. PubMed  Europe PubMed DOI  I
  27. Musyoka,T.M., Njuguna,J.N. and Tastan Bishop,O.
    Comparing sequence and structure of falcipains and human homologs at prodomain and catalytic active site for malarial peptide based inhibitor design
    Malar J (2019) 18, 159-159. PubMed  Europe PubMed DOI  PMC  EPMC
  28. Pasupureddy,R., Verma,S., Pant,A., Sharma,R., Seshadri,S., Pande,V., Saxena,A.K., Dixit,R. and Pandey,K.C.
    Crucial residues in falcipains that mediate hemoglobin hydrolysis
    Exp Parasitol (2019) 197, 43-50. PubMed  Europe PubMed DOI
  29. Rana,D., Kalamuddin,M., Sundriyal,S., Jaiswal,V., Sharma,G., Das Sarma,K., Sijwali,P.S., Mohmmed,A., Malhotra,P. and Mahindroo,N.
    Identification of antimalarial leads with dual falcipain-2 and falcipain-3 inhibitory activity
    Bioorg Med Chem (2019) , 115155-115155. PubMed  Europe PubMed DOI  I
  30. Stoye,A., Juillard,A., Tang,A.H., Legac,J., Gut,J., White,K.L., Charman,S.A., Rosenthal,P.J., Grau,G.E.R., Hunt,N.H. and Payne,R.J.
    Falcipain inhibitors based on the natural product gallinamide A are potent in vitro and in vivo antimalarials
    J Med Chem (2019) 62, 5562-5578. PubMed  Europe PubMed DOI  I
    31. 2018
  31. Aggarwal,S., Paliwal,D., Kaushik,D., Gupta,G.K. and Kumar,A.
    Pyrazole Schiff base hybrids as anti-malarial agents: synthesis, in vitro screening and computational study
    Comb Chem High Throughput Screen (2018) 21, 194-203. PubMed  Europe PubMed DOI  I
  32. Bekono,B.D., Ntie-Kang,F., Owono Owono,L.C. and Megnassan,E.
    Targeting cysteine proteases from Plasmodium falciparum: a general overview, rational drug design and computational approaches for drug discovery
    Curr Drug Targets (2018) 19, 501-526. PubMed  Europe PubMed DOI  I
  33. Hernandez-Gonzalez,J.E., Salas-Sarduy,E., Hernandez Ramirez,L.F., Pascual,M.J., Alvarez,D.E., Pabon,A., Leite,V.B.P., Pascutti,P.G. and Valiente,P.A.
    Identification of (4-(9H-fluoren-9-yl) piperazin-1-yl) methanone derivatives as falcipain 2 inhibitors active against Plasmodium falciparum cultures
    Biochim Biophys Acta Gen Subj (2018) 1862, 2911-2923. PubMed  Europe PubMed DOI  I
  34. Himangini, Pathak,D.P., Sharma,V. and Kumar,S.
    Designing novel inhibitors against falcipain-2 of Plasmodium falciparum
    Bioorg Med Chem Lett (2018) 28, 1566-1569. PubMed  Europe PubMed DOI  I
  35. Nizi,E., Sferrazza,A., Fabbrini,D., Nardi,V., Andreini,M., Graziani,R., Gennari,N., Bresciani,A., Paonessa,G. and Harper,S.
    Peptidomimetic nitrile inhibitors of malarial protease falcipain-2 with high selectivity against human cathepsins
    Bioorg Med Chem Lett (2018) 28, 1540-1544. PubMed  Europe PubMed DOI  I
  36. Pant,A., Kumar,R., Wani,N.A., Verma,S., Sharma,R., Pande,V., Saxena,A.K., Dixit,R., Rai,R. and Pandey,K.C.
    Allosteric site inhibitor disrupting auto-processing of malarial cysteine proteases
    Sci Rep (2018) 8, 16193-16193. PubMed  Europe PubMed DOI  PMC  EPMC
  37. Royo,S., Schirmeister,T., Kaiser,M., Jung,S., Rodriguez,S., Bautista,J.M. and Gonzalez,F.V.
    Antiprotozoal and cysteine proteases inhibitory activity of dipeptidyl enoates
    Bioorg Med Chem (2018) 26, 4624-4634. PubMed  Europe PubMed DOI  I
  38. Salawu,E.O.
    In silico study reveals how E64 approaches, binds to, and inhibits falcipain-2 of Plasmodium falciparum that causes malaria in humans
    Sci Rep (2018) 8, 16380-16380. PubMed  Europe PubMed DOI  PMC  EPMC  I
  39. Siddiqui,F.A., Cabrera,M., Wang,M., Brashear,A., Kemirembe,K., Wang,Z., Miao,J., Chookajorn,T., Yang,Z., Cao,Y., Dong,G., Rosenthal,P.J. and Cui,L.
    Plasmodium falciparum falcipain-2a polymorphisms in southeast Asia and their association with artemisinin resistance
    J Infect Dis (2018) 218, 434-442. PubMed  Europe PubMed DOI
    40. 2017
  40. Chen,W., Huang,Z., Wang,W., Mao,F., Guan,L., Tang,Y., Jiang,H., Li,J., Huang,J., Jiang,L. and Zhu,J.
    Discovery of new antimalarial agents: second-generation dual inhibitors against FP-2 and PfDHFR via fragments assembely
    Bioorg Med Chem (2017) 25, 6467-6478. PubMed  Europe PubMed DOI  I
  41. Hernandez Gonzalez,J.E., Hernandez Alvarez,L., Pascutti,P.G. and Valiente,P.A.
    Predicting binding modes of reversible peptide-based inhibitors of falcipain-2 consistent with structure-activity relationships
    Proteins (2017) 85, 1666-1683. PubMed  Europe PubMed DOI  I
  42. Previti,S., Ettari,R., Cosconati,S., Amendola,G., Chouchene,K., Wagner,A., Hellmich,U.A., Ulrich,K., Krauth-Siegel,R.L., Wich,P.R., Schmid,I., Schirmeister,T., Gut,J., Rosenthal,P.J., Grasso,S. and Zappala,M.
    Development of novel peptide-based Michael acceptors targeting rhodesain and falcipain-2 for the treatment of neglected tropical diseases (NTDs)
    J Med Chem (2017) 60, 6911-6923. PubMed  Europe PubMed DOI  I
  43. Rudrapal,M., Chetia,D. and Singh,V.
    Novel series of 1,2,4-trioxane derivatives as antimalarial agents
    J Enzyme Inhib Med Chem (2017) 32, 1159-1173. PubMed  Europe PubMed DOI  I
    44. 2016
  44. Bertoldo,J.B. and Terenzi,H.
    Oxidation and tyrosine nitration induce structural changes and inhibits Plasmodium falciparum falcipain-2 activity in vitro
    Protein Pept Lett (2016) 23, 562-572. PubMed  Europe PubMed
  45. Musyoka,T.M., Kanzi,A.M., Lobb,K.A. and Tastan Bishop,O.
    Structure based docking and molecular dynamic studies of plasmodial cysteine proteases against a South African natural compound and its analogs
    Sci Rep (2016) 6, 23690-23690. PubMed  Europe PubMed DOI  PMC  EPMC  I
  46. Musyoka,T.M., Kanzi,A.M., Lobb,K.A. and Tastan Bishop,O.
    Analysis of non-peptidic compounds as potential malarial inhibitors against plasmodial cysteine proteases via integrated virtual screening workflow
    J Biomol Struct Dyn (2016) 34, 2084-2101. PubMed  Europe PubMed DOI  I
  47. Ponsuwanna,P., Kochakarn,T., Bunditvorapoom,D., Kumpornsin,K., Otto,T.D., Ridenour,C., Chotivanich,K., Wilairat,P., White,N.J., Miotto,O. and Chookajorn,T.
    Comparative genome-wide analysis and evolutionary history of haemoglobin-processing and haem detoxification enzymes in malarial parasites
    Malar J (2016) 15, 51-51. PubMed  Europe PubMed DOI  PMC  EPMC
  48. Poongavanam,V. and Kongsted,J.
    Binding affinity models for falcipain inhibition based on the linear interaction energy method
    J Mol Graph Model (2016) 70, 236-245. PubMed  Europe PubMed DOI  I
  49. Schmidt,I., Pradel,G., Sologub,L., Golzmann,A., Ngwa,C.J., Kucharski,A., Schirmeister,T. and Holzgrabe,U.
    Bistacrine derivatives as new potent antimalarials
    Bioorg Med Chem (2016) 24, 3636-3642. PubMed  Europe PubMed DOI  I
  50. Thillainayagam,M., Anbarasu,A. and Ramaiah,S.
    Comparative molecular field analysis and molecular docking studies on novel aryl chalcone derivatives against an important drug target cysteine protease in Plasmodium falciparum
    J Theor Biol (2016) 403, 110-128. PubMed  Europe PubMed DOI  I
    51. 2015
  51. Bertoldo,J.B., Chiaradia-Delatorre,L.D., Mascarello,A., Leal,P.C., Cordeiro,M.N., Nunes,R.J., Sarduy,E.S., Rosenthal,P.J. and Terenzi,H.
    Synthetic compounds from an in house library as inhibitors of falcipain-2 from Plasmodium falciparum
    J Enzyme Inhib Med Chem (2015) 30, 299-307. PubMed  Europe PubMed DOI  I
  52. Chakka,S.K., Kalamuddin,M., Sundararaman,S., Wei,L., Mundra,S., Mahesh,R., Malhotra,P., Mohmmed,A. and Kotra,L.P.
    Identification of novel class of falcipain-2 inhibitors as potential antimalarial agents
    Bioorg Med Chem (2015) 23, 2221-2240. PubMed  Europe PubMed DOI  I
  53. Marques,A.F., Gomes,P.S., Oliveira,P.L., Rosenthal,P.J., Pascutti,P.G. and Lima,L.M.
    Allosteric regulation of the Plasmodium falciparum cysteine protease falcipain-2 by heme
    Arch Biochem Biophys (2015) 573, 92-99. PubMed  Europe PubMed DOI
  54. Omotuyi,I.O. and Hamada,T.
    Dynamical footprint of falcipain-2 catalytic triad in hemoglobin-beta-bound state
    J Biomol Struct Dyn (2015) 33, 1027-1036. PubMed  Europe PubMed DOI
  55. Sharma,R.K., Younis,Y., Mugumbate,G., Njoroge,M., Gut,J., Rosenthal,P.J. and Chibale,K.
    Synthesis and structure-activity-relationship studies of thiazolidinediones as antiplasmodial inhibitors of the Plasmodium falciparum cysteine protease falcipain-2
    Eur J Med Chem (2015) 90C, 507-518. PubMed  Europe PubMed DOI  I
  56. Singh,A.K., Rajendran,V., Pant,A., Ghosh,P.C., Singh,N., Latha,N., Garg,S., Pandey,K.C., Singh,B.K. and Rathi,B.
    Design, synthesis and biological evaluation of functionalized phthalimides: a new class of antimalarials and inhibitors of falcipain-2, a major hemoglobinase of malaria parasite
    Bioorg Med Chem (2015) 23, 1817-1827. PubMed  Europe PubMed DOI  I
    57. 2014
  57. Arafet,K., Ferrer,S., Marti,S. and Moliner,V.
    Quantum mechanics/molecular mechanics studies of the mechanism of falcipain-2 inhibition by the epoxysuccinate E64
    Biochemistry (2014) 53, 3336-3346. PubMed  Europe PubMed DOI  I
  58. Conrad,M.D., Bigira,V., Kapisi,J., Muhindo,M., Kamya,M.R., Havlir,D.V., Dorsey,G. and Rosenthal,P.J.
    Polymorphisms in K13 and falcipain-2 associated with artemisinin resistance are not prevalent in Plasmodium falciparum isolated from Ugandan children
    PLoS ONE (2014) 9, e105690-e105690. PubMed  Europe PubMed DOI  PMC  EPMC
  59. Conroy,T., Guo,J.T., Elias,N., Cergol,K.M., Gut,J., Legac,J., Khatoon,L., Liu,Y., McGowan,S., Rosenthal,P.J., Hunt,N.H. and Payne,R.J.
    Synthesis of gallinamide A analogues as potent falcipain inhibitors and antimalarials
    J Med Chem (2014) 57, 10557-10563. PubMed  Europe PubMed DOI  I
  60. Ettari,R., Pinto,A., Tamborini,L., Angelo,I.C., Grasso,S., Zappala,M., Capodicasa,N., Yzeiraj,L., Gruber,E., Aminake,M.N., Pradel,G., Schirmeister,T., De Micheli,C. and Conti,P.
    Synthesis and biological evaluation of papain-family cathepsin L-like cysteine protease inhibitors containing a 1,4-benzodiazepine scaffold as antiprotozoal agents
    ChemMedChem (2014) 9, 1817-1825. PubMed  Europe PubMed DOI  I
  61. Jin,H., Xu,Z., Cui,K., Zhang,T., Lu,W. and Huang,J.
    Dietary flavonoids fisetin and myricetin: dual inhibitors of Plasmodium falciparum falcipain-2 and plasmepsin II
    Fitoterapia (2014) 94, 55-61. PubMed  Europe PubMed DOI  I
  62. Omotuyi,O.I.
    Methyl-methoxylpyrrolinone and flavinium nucleus binding signatures on falcipain-2 active site
    J Mol Model (2014) 20, 2386-2386. PubMed  Europe PubMed DOI  I
  63. Wang,L., Zhang,S., Zhu,J., Zhu,L., Liu,X., Shan,L., Huang,J., Zhang,W. and Li,H.
    Identification of diverse natural products as falcipain-2 inhibitors through structure-based virtual screening
    Bioorg Med Chem Lett (2014) 24, 1261-1264. PubMed  Europe PubMed DOI  I
  64. Weldon,D.J., Shah,F., Chittiboyina,A.G., Sheri,A., Chada,R.R., Gut,J., Rosenthal,P.J., Shivakumar,D., Sherman,W., Desai,P., Jung,J.C. and Avery,M.A.
    Synthesis, biological evaluation, hydration site thermodynamics, and chemical reactivity analysis of alpha-keto substituted peptidomimetics for the inhibition of Plasmodium falciparum
    Bioorg Med Chem Lett (2014) 24, 1274-1279. PubMed  Europe PubMed DOI  I
    65. 2013
  65. Chugh,M., Sundararaman,V., Kumar,S., Reddy,V.S., Siddiqui,W.A., Stuart,K.D. and Malhotra,P.
    Protein complex directs hemoglobin-to-hemozoin formation in Plasmodium falciparum
    Proc Natl Acad Sci U S A (2013) 110, 5392-5397. PubMed  Europe PubMed DOI
  66. Cotrin,S.S., Gouvea,I.E., Melo,P.M., Bagnaresi,P., Assis,D.M., Araujo,M.S., Juliano,M.A., Gazarini,M.L., Rosenthal,P.J., Juliano,L. and Carmona,A.K.
    Substrate specificity studies of the cysteine peptidases falcipain-2 and falcipain-3 from Plasmodium falciparum and demonstration of their kininogenase activity
    Mol Biochem Parasitol (2013) 187, 111-116. PubMed  Europe PubMed DOI  P
  67. Mane,U.R., Gupta,R.C., Nadkarni,S.S., Giridhar,R.R., Naik,P.P. and Yadav,M.R.
    Falcipain inhibitors as potential therapeutics for resistant strains of malaria: a patent review
    Expert Opin Ther Pat (2013) 23, 165-187. PubMed  Europe PubMed DOI  V  I
  68. Marques,A.F., Esser,D., Rosenthal,P.J., Kassack,M.U. and Lima,L.M.
    Falcipain-2 inhibition by suramin and suramin analogues
    Bioorg Med Chem (2013) 21, 3667-3673. PubMed  Europe PubMed DOI  I
  69. Mugumbate,G., Newton,A.S., Rosenthal,P.J., Gut,J., Moreira,R., Chibale,K. and Guedes,R.C.
    Novel anti-Plasmodial hits identified by virtual screening of the ZINC database
    J Comput Aided Mol Des (2013) 27, 859-871. PubMed  Europe PubMed DOI  I
  70. Somanadhan,B., Kotturi,S.R., Yan Leong,C., Glover,R.P., Huang,Y., Flotow,H., Buss,A.D., Lear,M.J. and Butler,M.S.
    Isolation and synthesis of falcitidin, a novel myxobacterial-derived acyltetrapeptide with activity against the malaria target falcipain-2
    J Antibiot (Tokyo) (2013) 66, 259-264. PubMed  Europe PubMed DOI  I
  71. Tadigoppula,N., Korthikunta,V., Gupta,S., Kancharla,P., Khaliq,T., Soni,A., Srivastava,R.K., Srivastava,K., Puri,S.K., Raju,K.S., Wahajuddin, Sijwali,P.S., Kumar,V. and Mohammad,I.S.
    Synthesis and insight into the structure-activity relationships of chalcones as antimalarial agents
    J Med Chem (2013) 56, 31-45. PubMed  Europe PubMed DOI  I
  72. Wang,J., Li,Y., Yang,Y., Zhang,S. and Yang,L.
    Profiling the structural determinants of heteroarylnitrile scaffold-based derivatives as falcipain-2 inhibitors by in silico methods
    Curr Med Chem (2013) 20, 2032-2042. PubMed  Europe PubMed  I
    73. 2012
  73. Bagnaresi,P., de Barros,N.M., Assis,D.M., Melo,P.M., Fonseca,R.G., Juliano,M.A., Pesquero,J.B., Juliano,L., Rosenthal,P.J., Carmona,A.K. and Gazarini,M.L.
    Intracellular proteolysis of kininogen by malaria parasites promotes release of active kinins
    Malar J (2012) 11, 156-156. PubMed  Europe PubMed DOI
  74. Ettari,R., Micale,N., Grazioso,G., Bova,F., Schirmeister,T., Grasso,S. and Zappala,M.
    Synthesis and molecular modeling studies of derivatives of a highly potent peptidomimetic vinyl ester as falcipain-2 inhibitors
    ChemMedChem (2012) 7, 1594-1600. PubMed  Europe PubMed DOI  I
  75. Grazioso,G., Legnani,L., Toma,L., Ettari,R., Micale,N. and De Micheli,C.
    Mechanism of falcipain-2 inhibition by alpha,beta-unsaturated benzo[1,4]diazepin-2-one methyl ester
    J Comput Aided Mol Des (2012) 26, 1035-1043. PubMed  Europe PubMed DOI  I
  76. Huang,H., Lu,W., Li,X., Cong,X., Ma,H., Liu,X., Zhang,Y., Che,P., Ma,R., Li,H., Shen,X., Jiang,H., Huang,J. and Zhu,J.
    Design and synthesis of small molecular dual inhibitor of falcipain-2 and dihydrofolate reductase as antimalarial agent
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