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Literature for peptidase C01.005: stem bromelain

Summary Alignment Sequences Sequence features Distribution Structure Literature Substrates

(Topics flags: A Assay, S Structure, P Specificity, I Inhibitor, E Expression, U Therapeutic, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Kumar,V., Mangla,B., Javed,S., Ahsan,W., Kumar,P., Garg,V. and Dureja,H.
    Correction: Bromelain: a review of its mechanisms, pharmacological effects and potential applications
    Food Funct (2025) PubMed  Europe PubMed DOI
  2. Lugo,M.C., Kammura,A., Kobayashi,T., Ito,M., Harada,T. and Umemura,K.
    Amyloidogenic Growth Observation of Stem Bromelain via Atomic Force Microscopy
    ACS Omega (2025) 10, 49002-49009. PubMed  Europe PubMed DOI  PMC  EPMC
    3. 2024
  3. Chiarelli,P.G., Martinez,B., Nakamura,T. and Mis Solval,K.
    Enhancing Bromelain Recovery from Pineapple By-Products: A Sustainable Approach for Value Addition and Waste Reduction
    Foods (2024) 13 PubMed  Europe PubMed DOI  PMC  EPMC
  4. Kansakar,U., Trimarco,V., Manzi,M.V., Cervi,E., Mone,P. and Santulli,G.
    Exploring the Therapeutic Potential of Bromelain: Applications, Benefits, and Mechanisms
    Nutrients (2024) 16 PubMed  Europe PubMed DOI  PMC  EPMC  V
  5. Kaushal,R., Kaur,B., Panesar,P.S., Anal,A.K. and Chu-Ky,S.
    Valorization of pineapple rind for bromelain extraction using microwave assisted technique: optimization, purification, and structural characterization
    J Food Sci Technol (2024) 61, 551-562. PubMed  Europe PubMed DOI  PMC  EPMC
  6. Khan,T., Halder,B., Das,N. and Sen,P.
    Role of Associated Water Dynamics on Protein Stability and Activity in Crowded Milieu
    J Phys Chem B (2024) 128, 8672-8686. PubMed  Europe PubMed DOI
  7. Locci,C., Chicconi,E. and Antonucci,R.
    Current Uses of Bromelain in Children: A Narrative Review
    Children (Basel) (2024) 11 PubMed  Europe PubMed DOI  PMC  EPMC  V
  8. Pillai,K., Akhter,J., Mekkawy,A.H., Valle,S.J. and Morris,D.L.
    Development and Validation of Micro-Azocasein Assay for Quantifying Bromelain
    Methods Protoc (2024) 7 PubMed  Europe PubMed DOI  PMC  EPMC
  9. Porfirio,M.C.P., Santos,J.B., Alves,A.N., Santos,L.S., Bonomo,R.C.F. and da Costa Ilheu Fontan,R.
    Purification of pineapple bromelain by IMAC chromatography using chlorophyll-activated macroporous matrices
    J Chromatogr B Analyt Technol Biomed Life Sci (2024) 1234, 124027-124027. PubMed  Europe PubMed DOI
  10. Wajih,N., Erali,R.A., Forsythe,S.D., Schaaf,C.R., Shen,P., Levine,E.A., Soker,S., Morris,D.L. and Votanopoulos,K.I.
    Enhancing the Efficacy of HIPEC Through Bromelain: A Preclinical Investigation in Appendiceal Cancer
    Ann Surg Oncol (2024) 31, 5377-5389. PubMed  Europe PubMed DOI
    11. 2023
  11. Kumar,V., Mangla,B., Javed,S., Ahsan,W., Kumar,P., Garg,V. and Dureja,H.
    Bromelain: a review of its mechanisms, pharmacological effects and potential applications
    Food Funct (2023) 14, 8101-8128. PubMed  Europe PubMed DOI
  12. Leelakanok,N., Petchsomrit,A., Janurai,T., Saechan,C. and Sunsandee,N.
    Efficacy and safety of bromelain: A systematic review and meta-analysis
    Nutr Health (2023) , 2601060231173732-2601060231173732. PubMed  Europe PubMed DOI
  13. Liu,X., Huang,Q., Pan,P., Fang,M., Zhang,Y., Yang,S., Li,M. and Liu,Y.
    Comparative Study of the Preparation of High-Molecular-Weight Fibroin by Degumming Silk with Several Neutral Proteases
    Polymers (Basel) (2023) 15 PubMed  Europe PubMed DOI  PMC  EPMC
  14. Sharma,G. and Vimal,A.
    Bromelain: An Enzyme Expanding its Horizon from Food to Pharmaceutical Industry
    Curr Pharm Biotechnol (2023) 24, 1715-1726. PubMed  Europe PubMed DOI  V
  15. Wen,H.K., Valle,S.J. and Morris,D.L.
    Bromelain and acetylcysteine (BromAc((R))): a novel approach to the treatment of mucinous tumours
    Am J Cancer Res (2023) 13, 1522-1532. PubMed  Europe PubMed  PMC  EPMC  V
    16. 2022
  16. Agrawal,P., Nikhade,P., Patel,A., Mankar,N. and Sedani,S.
    Bromelain: A Potent Phytomedicine
    Cureus (2022) 14, e27876-e27876. PubMed  Europe PubMed DOI  PMC  EPMC  V
  17. Fathi,A.N., Babaei,S., Babaei,S., Baazm,M., Sakhaie,H. and Babaei,S.
    Effect of bromelain on mast cell numbers and degranulation in diabetic rat wound healing
    J Wound Care (2022) 31, S4-S4. PubMed  Europe PubMed DOI
  18. Gamarra,F.M.C., Santana,J.C.C., Llanos,S.A.V., Perez,J.A.H., Flausino,F.R., Quispe,A.P.B., Mendoza,P.C., Vanalle,R.M., Carreno-Farfan,C., Berssaneti,F.T., de Souza,R.R. and Tambourgi,E.B.
    High Retention and Purification of Bromelain Enzyme (Ananas comosus L. Merrill) from Pineapple Juice Using Plain and Hollow Polymeric Membranes Techniques
    Polymers (Basel) (2022) 14 PubMed  Europe PubMed DOI  PMC  EPMC
  19. Pezzani,R., Jimenez-Garcia,M., Capo,X., Sonmez Gurer,E., Sharopov,F., Rachel,T.Y.L., Ntieche Woutouoba,D., Rescigno,A., Peddio,S., Zucca,P., Tsouh Fokou,P.V., Martorell,M., Gulsunoglu-Konuskan,Z., Ydyrys,A., Bekzat,T., Gulmira,T., Hano,C., Sharifi-Rad,J. and Calina,D.
    Anticancer properties of bromelain: State-of-the-art and recent trends
    Front Oncol (2022) 12, 1068778-1068778. PubMed  Europe PubMed DOI  PMC  EPMC  V
    20. 2021
  20. Arkoulis,N., Mabvuure,N.T., Smith,A. and Barnes,D.E.
    Early experiences using bromelain-based enzymatic debridement in a tertiary burns centre in the United Kingdom: A retrospective case series review
    J Plast Reconstr Aesthet Surg (2021) 74, 1402-1407. PubMed  Europe PubMed DOI
  21. Ataide,J.A., Cefali,L.C., Figueiredo,M.C., Braga,L.E.O., Ruiz,A.L.T.G., Foglio,M.A., Oliveira-Nascimento,L. and Mazzola,P.G.
    In vitro performance of free and encapsulated bromelain
    Sci Rep (2021) 11, 10195-10195. PubMed  Europe PubMed DOI  PMC  EPMC
  22. Hikisz,P. and Bernasinska-Slomczewska,J.
    Beneficial Properties of Bromelain
    Nutrients (2021) 13 PubMed  Europe PubMed DOI  PMC  EPMC  V
  23. Varilla,C., Marcone,M., Paiva,L. and Baptista,J.
    Bromelain, a Group of Pineapple Proteolytic Complex Enzymes (Ananas comosus) and Their Possible Therapeutic and Clinical Effects. A Summary
    Foods (2021) 10 PubMed  Europe PubMed DOI  PMC  EPMC
  24. Zhou,W., Ye,C., Geng,L., Chen,G., Wang,X., Chen,W., Sa,R., Zhang,J. and Zhang,X.
    Purification and characterization of bromelain from pineapple (Ananas comosus L.) peel waste
    J Food Sci (2021) 86, 385-393. PubMed  Europe PubMed DOI
    25. 2020
  25. Azarkan,M., Maquoi,E., Delbrassine,F., Herman,R., M'rabet,N., Calvo Esposito,R., Charlier,P. and Kerff,F.
    Structures of the free and inhibitors-bound forms of bromelain and ananain from Ananas comosus stem and in vitro study of their cytotoxicity
    Sci Rep (2020) 10, 19570-19570. PubMed  Europe PubMed DOI  PMC  EPMC  I
  26. Bakare,A.O. and Owoyele,B.V.
    Antinociceptive and neuroprotective effects of bromelain in chronic constriction injury-induced neuropathic pain in Wistar rats
    Korean J Pain (2020) 33, 13-22. PubMed  Europe PubMed DOI
  27. Bakare,A.O. and Owoyele,B.V.
    Bromelain reversed electrolyte imbalance in the chronically constricted sciatic nerve of Wistar rats
    Naunyn Schmiedebergs Arch Pharmacol (2020) 393, 457-467. PubMed  Europe PubMed DOI  U
  28. Gross,P., Seelert,H., Meiser,P. and Muller,R.
    Characterization of bromelain indicates a molar excess of inhibitor vs. enzyme molecules, a Jacalin-like lectin and Maillard reaction products
    J Pharm Biomed Anal (2020) 181, 113075-113075. PubMed  Europe PubMed DOI
  29. Harats,M., Haik,J., Cleary,M., Vashurin,I., Aviv,U. and Kornhaber,R.
    A retrospective review of an off-label bromelain-based selective enzymatic debridement (Nexobrid(R)) in the treatment of deep, partial, and full thickness burns and hard to heal wounds
    Isr Med Assoc J (2020) 22, 83-88. PubMed  Europe PubMed  U
  30. Jebur,A.B., El-Demerdash,F.M. and Kang,W.
    Bromelain from Ananas comosus stem attenuates oxidative toxicity and testicular dysfunction caused by aluminum in rats
    J Trace Elem Med Biol (2020) 62, 126631-126631. PubMed  Europe PubMed DOI
  31. Kritis,P., Karampela,I., Kokoris,S. and Dalamaga,M.
    The combination of bromelain and curcumin as an immune-boosting nutraceutical in the prevention of severe COVID-19
    Metabol Open (2020) 8, 100066-100066. PubMed  Europe PubMed DOI  PMC  EPMC  I
  32. Mekkawy,M.H., Fahmy,H.A., Nada,A.S. and Ali,O.S.
    Study of the Radiosensitizing and Radioprotective Efficacy of Bromelain (a Pineapple Extract): In Vitro and In Vivo
    Integr Cancer Ther (2020) 19, 1534735420950468-1534735420950468. PubMed  Europe PubMed DOI  PMC  EPMC
  33. Mogha,N.K., Sindhu,A. and Venkatesu,P.
    A biophysical strategy to examine the impact of newly synthesized polymerizable ammonium-based ionic liquids on the structural stability and proteolytic activity of stem bromelain
    Int J Biol Macromol (2020) 151, 957-966. PubMed  Europe PubMed DOI
    34. 2019
  34. De Souza,G.M., Fernandes,I.A., Dos Santos,C.R.R. and Falci,S.G.M.
    Is bromelain effective in controlling the inflammatory parameters of pain, edema, and trismus after lower third molar surgery? A systematic review and meta-analysis
    Phytother Res (2019) 33, 473-481. PubMed  Europe PubMed DOI  U
  35. Ghensi,P., Cucchi,A., Bonaccorso,A., Ferroni,L., Gardin,C., Mortellaro,C. and Zavan,B.
    In vitro effect of bromelain on the regenerative properties of mesenchymal stem cells
    J Craniofac Surg (2019) 30, 1064-1067. PubMed  Europe PubMed DOI  U
  36. Han,J., Wang,L., Wang,L., Li,C., Mao,Y. and Wang,Y.
    Fabrication of a core-shell-shell magnetic polymeric microsphere with excellent performance for separation and purification of bromelain
    Food Chem (2019) 283, 1-10. PubMed  Europe PubMed DOI
  37. Han,J., Cai,Y., Wang,L., Mao,Y., Ni,L. and Wang,Y.
    A high efficiency method combining metal chelate ionic liquid-based aqueous two-phase flotation with two-step precipitation process for bromelain purification
    Food Chem (2019) , 125749-125749. PubMed  Europe PubMed DOI
  38. Lee,J.H., Lee,J.T., Park,H.R. and Kim,J.B.
    The potential use of bromelain as a natural oral medicine having anticarcinogenic activities
    Food Sci Nutr (2019) 7, 1656-1667. PubMed  Europe PubMed DOI  PMC  EPMC  U
  39. Luo,P., Han,J., Li,Y., Wang,Y., Wang,L. and Ni,L.
    Preparation of dendritic polymer-based magnetic carrier for application of bromelain separation and purification
    J Food Biochem (2019) 43, e12976-e12976. PubMed  Europe PubMed DOI
  40. Mendes,M.L., do Nascimento-Junior,E.M., Reinheimer,D.M. and Martins-Filho,P.R.
    Efficacy of proteolytic enzyme bromelain on health outcomes after third molar surgery. Systematic review and meta-analysis of randomized clinical trials
    Med Oral Patol Oral Cir Bucal (2019) 24, e61-e61. PubMed  Europe PubMed DOI
  41. Mohamad,N.E., Abu,N., Yeap,S.K. and Alitheen,N.B.
    Bromelain enhances the anti-tumor effects of cisplatin on 4T1 breast tumor model in vivo
    Integr Cancer Ther (2019) 18, 1534735419880258-1534735419880258. PubMed  Europe PubMed DOI  U
  42. Orlandi-Mattos,P.E., Aguiar,R.B., da Silva Vaz I Junior, Moraes,J.Z., de Araujo Carlini,E.L., Juliano,M.A. and Juliano,L.
    Enkephalin related peptides are released from jejunum wall by orally ingested bromelain
    Peptides (2019) 115, 32-42. PubMed  Europe PubMed DOI
  43. Raeisi,F., Raeisi,E., Heidarian,E., Shahbazi-Gahroui,D. and Lemoigne,Y.
    Bromelain inhibitory effect on colony formation: an in vitro study on human AGS, PC3, and MCF7 cancer cells
    J Med Signals Sens (2019) 9, 267-273. PubMed  Europe PubMed DOI  PMC  EPMC  U
  44. Taskin,A., Tarakcioglu,M., Ulusal,H., Orkmez,M. and Taysi,S.
    Idarubicin-bromelain combination sensitizes cancer cells to conventional chemotherapy
    Iran J Basic Med Sci (2019) 22, 1172-1178. PubMed  Europe PubMed DOI  PMC  EPMC
    45. 2018
  45. Ataide,J.A., Gerios,E.F., Mazzola,P.G. and Souto,E.B.
    Bromelain-loaded nanoparticles: a comprehensive review of the state of the art
    Adv Colloid Interface Sci (2018) 254, 48-55. PubMed  Europe PubMed DOI
  46. Berner,J.E., Keckes,D., Pywell,M. and Dheansa,B.
    Limitations to the use of bromelain-based enzymatic debridement (NexoBrid((R))) for treating diabetic foot burns: a case series of disappointing results
    Scars Burn Heal (2018) 4, 2059513118816534-2059513118816534. PubMed  Europe PubMed DOI  PMC  EPMC  U
  47. Feng,X., Hang,S., Zhou,Y., Liu,Q. and Yang,H.
    Bromelain kinetics and mechanism on myofibril from golden pomfret (Trachinotus blochii)
    J Food Sci (2018) 83, 2148-2158. PubMed  Europe PubMed DOI
  48. Jha,I., Bisht,M., Mogha,N.K. and Venkatesu,P.
    Effect of imidazolium-based ionic liquids on the structure and stability of stem bromelain: concentration and alkyl chain length effect
    J Phys Chem B (2018) 122, 7522-7529. PubMed  Europe PubMed DOI
  49. Kumar,P.K., Bisht,M., Venkatesu,P., Bahadur,I. and Ebenso,E.E.
    Exploring the effect of choline-based ionic liquids on the stability and activity of stem bromelain
    J Phys Chem B (2018) 122, 10435-10444. PubMed  Europe PubMed DOI
  50. Loo,Y.L., Goh,B.K.L. and Jeffery,S.
    An overview of the use of bromelain-based enzymatic debridement (Nexobrid(R)) in deep partial and full thickness burns: appraising the evidence
    J Burn Care Res (2018) 39, 932-938. PubMed  Europe PubMed DOI  U
  51. Park,S., Oh,J., Kim,M. and Jin,E.J.
    Bromelain effectively suppresses Kras-mutant colorectal cancer by stimulating ferroptosis
    Animal Cells Syst (Seoul) (2018) 22, 334-340. PubMed  Europe PubMed DOI  PMC  EPMC  U
  52. Rajan,S.G., Sharma,A., Kumari,P. and Biswas,S.
    Comparative molecular characterization to reveal surface behaviour of non-proteolytic bromelain mutants
    Curr Pharm Biotechnol (2018) 19, 886-895. PubMed  Europe PubMed DOI
  53. Ramli,A.N.M., Manas,N.H.A., Hamid,A.A.A., Hamid,H.A. and Illias,R.M.
    Comparative structural analysis of fruit and stem bromelain from Ananas comosus
    Food Chem (2018) 266, 183-191. PubMed  Europe PubMed DOI  S
  54. Sancesario,G.M., Nuccetelli,M., Cerri,A., Zegeer,J., Severini,C., Ciotti,M.T., Pieri,M., Martorana,A., Caltagirone,C., Nistico,R. and Bernardini,S.
    Bromelain degrades Abeta1-42 monomers and soluble aggregates: an in vitro study in cerebrospinal fluid of Alzheimer's disease patients
    Curr Alzheimer Res (2018) 15, 628-636. PubMed  Europe PubMed DOI
  55. Schulz,A., Fuchs,P.C., Hans,N., Oplander,C., Valdez,L.B. and Schiefer,J.L.
    Inhibition of bromelain activity during enzymatic debridement of burn wounds pretreated with frequently used products
    J Burn Care Res (2018) 39, 413-422. PubMed  Europe PubMed DOI
  56. Shoham,Y., Krieger,Y., Tamir,E., Silberstein,E., Bogdanov-Berezovsky,A., Haik,J. and Rosenberg,L.
    Bromelain-based enzymatic debridement of chronic wounds: a preliminary report
    Int Wound J (2018) 15, 769-775. PubMed  Europe PubMed DOI  U
  57. Singer,A.J., Toussaint,J., Chung,W.T., McClain,S.A., Clark,R.A.F., Asculai,E., Geblinger,D. and Rosenberg,L.
    Development of a contaminated ischemic porcine wound model and the evaluation of bromelain based enzymatic debridement
    Burns (2018) 44, 896-904. PubMed  Europe PubMed DOI  U
  58. Soheilifar,S., Bidgoli,M., Hooshyarfard,A., Shahbazi,A., Vahdatinia,F. and Khoshkhooie,F.
    Effect of oral bromelain on wound healing, pain, and bleeding at donor site following free gingival grafting: a clinical trial
    J Dent (Tehran) (2018) 15, 309-316. PubMed  Europe PubMed  PMC  EPMC  U
  59. Xu,X., Liu,R., Guo,P., Luo,Z., Cai,X., Shu,H., Ge,Y., Chang,C. and Fu,Q.
    Fabrication of a novel magnetic mesoporous molecularly imprinted polymer based on pericarpium granati-derived carrier for selective absorption of bromelain
    Food Chem (2018) 256, 91-97. PubMed  Europe PubMed DOI
    60. 2017
  60. Bhakuni,K. and Venkatesu,P.
    Crowded milieu tuning the stability and activity of stem bromelain
    Int J Biol Macromol (2017) 109, 114-123. PubMed  Europe PubMed DOI
  61. Hirche,C., Citterio,A., Hoeksema,H., Koller,J., Lehner,M., Martinez,J.R., Monstrey,S., Murray,A., Plock,J.A., Sander,F., Schulz,A., Ziegler,B. and Kneser,U.
    Eschar removal by bromelain based enzymatic debridement (Nexobrid(R)) in burns: an European consensus
    Burns (2017) 43, 1640-1653. PubMed  Europe PubMed DOI
  62. Luniak,N., Meiser,P., Burkart,S. and Muller,R.
    Heterologous expression of the plant cysteine protease bromelain and its inhibitor in Pichia pastoris
    Biotechnol Prog (2017) 33, 54-65. PubMed  Europe PubMed DOI  E
  63. Matagne,A., Bolle,L., El Mahyaoui,R., Baeyens-Volant,D. and Azarkan,M.
    The proteolytic system of pineapple stems revisited: purification and characterization of multiple catalytically active forms
    Phytochemistry (2017) 138, 29-51. PubMed  Europe PubMed DOI
  64. Muhammad,Z.A. and Ahmad,T.
    Therapeutic uses of pineapple-extracted bromelain in surgical care - a review
    J Pak Med Assoc (2017) 67, 121-125. PubMed  Europe PubMed  V  U
  65. Nor,M.Z.M., Ramchandran,L., Duke,M. and Vasiljevic,T.
    Integrated ultrafiltration process for the recovery of bromelain from pineapple waste mixture
    J Food Process Eng (2017) 40, e12492- DOI
  66. Oliveira,C.P., Prado,W.A., Lavayen,V., Buttenbender,S.L., Beckenkamp,A., Martins,B.S., Ludtke,D.S., Campo,L.F., Rodembusch,F.S., Buffon,A., Pessoa,A., Jr., Guterres,S.S. and Pohlmann,A.R.
    Bromelain-functionalized multiple-wall lipid-core nanocapsules: formulation, chemical structure and antiproliferative effect against human breast cancer cells (MCF-7)
    Pharm Res (2017) 34, 438-452. PubMed  Europe PubMed DOI  U
  67. Zaman,M., Zakariya,S.M., Nusrat,S., Khan,M.V., Qadeer,A., Ajmal,M.R. and Khan,R.H.
    Surfactant-mediated amyloidogenesis behavior of stem bromelain; a biophysical insight
    J Biomol Struct Dyn (2017) 35, 1407-1419. PubMed  Europe PubMed DOI
    68. 2016
  68. Belcher,M.D., Kaddour-Djebbar,I., Bollag,W.B. and Davis,L.S.
    The proteolytic effect of bromelain on bullous pemphigoid antigen-2
    J Am Acad Dermatol (2016) 75, 838-840. PubMed  Europe PubMed DOI  U
  69. Bernela,M., Ahuja,M. and Thakur,R.
    Enhancement of anti-inflammatory activity of bromelain by its encapsulation in katira gum nanoparticles
    Carbohydr Polym (2016) 143, 18-24. PubMed  Europe PubMed DOI  U
  70. Bhatnagar,P., Pant,A.B., Shukla,Y., Panda,A. and Gupta,K.C.
    Hyaluronic acid grafted PLGA copolymer nanoparticles enhance the targeted delivery of Bromelain in Ehrlich's Ascites Carcinoma
    Eur J Pharm Biopharm (2016) 105, 176-192. PubMed  Europe PubMed DOI  U
  71. Bormann,K.H., Weber,K., Kloppenburg,H., Staude,P., Koch,A., Meiser,P. and Gellrich,N.C.
    Perioperative bromelain therapy after wisdom teeth extraction - a randomized, placebo-controlled, double-blinded, three-armed, cross-over dose-finding study
    Phytother Res (2016) 30, 2012-2019. PubMed  Europe PubMed DOI  U
  72. Coelho,D.F., Saturnino,T.P., Fernandes,F.F., Mazzola,P.G., Silveira,E. and Tambourgi,E.B.
    Azocasein substrate for determination of proteolytic activity: reexamining a traditional method using bromelain samples
    Biomed Res Int (2016) 2016, 8409183-8409183. PubMed  Europe PubMed DOI  PMC  EPMC  A
  73. DaSilva,F.R.P., Vasconcelos,A.C.C.G., Alves,E.H.P., DeOliveira Junior,P.V., DeOliveira,J.S. and Vasconcelos,D.F.P.
    Bromelain: a potential strategy for the adjuvant treatment of periodontitis
    Dent Hypotheses (2016) 7, 88-93. DOI  U
  74. de Lencastre Novaes,L.C., Jozala,A.F., Lopes,A.M., de Carvalho Santos-Ebinuma,V., Mazzola,P.G. and Pessoa Junior,A.
    Stability, purification, and applications of bromelain: a review
    Biotechnol Prog (2016) 32, 5-13. PubMed  Europe PubMed DOI
  75. Errasti,M.E., Prospitti,A., Viana,C.A., Gonzalez,M.M., Ramos,M.V., Rotelli,A.E. and Caffini,N.O.
    Effects on fibrinogen, fibrin, and blood coagulation of proteolytic extracts from fruits of Pseudananas macrodontes, Bromelia balansae, and B. hieronymi (Bromeliaceae) in comparison with bromelain
    Blood Coagul Fibrinolysis (2016) 27, 441-449. PubMed  Europe PubMed DOI
  76. Kasemsuk,T., Saengpetch,N., Sibmooh,N. and Unchern,S.
    Improved WOMAC score following 16-week treatment with bromelain for knee osteoarthritis
    Clin Rheumatol (2016) 35, 2531-2540. PubMed  Europe PubMed DOI  U
  77. Ley,C.M., Ni,Q., Liao,X., Gao,H.L. and Robinson,N.
    Bromelain and cardiovascular risk factors in diabetes: an exploratory randomized, placebo controlled, double blind clinical trial
    Chin J Integr Med (2016) 22, 728-737. PubMed  Europe PubMed DOI
  78. Li,R., Ding,L., Wu,Z., Wang,Y., Liu,W. and Wang,Y.
    beta-Cyclodextrin assisted two-stage foam fractionation of bromelain from the crude extract of pineapple peels
    Ind Crops Prod (2016) 94, 233-239. DOI
  79. Li,Y., Zhou,J., Wang,W. and Wang,J.
    Bromelain treatment of wheat flour to reduce the allergenicity
    J Chin Cereals Oils Assoc (2016) 31, 56-60.
  80. Mohan,R., Sivakumar,V., Rangasamy,T. and Muralidharan,C.
    Optimisation of bromelain enzyme extraction from pineapple (Ananas comosus) and application in process industry
    Am J Biochem Biotechnol (2016) 12, 188-195. DOI
  81. Muller,A., Barat,S., Chen,X., Bui,K.C., Bozko,P., Malek,N.P. and Plentz,R.R.
    Comparative study of antitumor effects of bromelain and papain in human cholangiocarcinoma cell lines
    Int J Oncol (2016) 48, 2025-2034. PubMed  Europe PubMed DOI  U
  82. Pauzi,A.Z., Yeap,S.K., Abu,N., Lim,K.L., Omar,A.R., Aziz,S.A., Chow,A.L., Subramani,T., Tan,S.G. and Alitheen,N.B.
    Combination of cisplatin and bromelain exerts synergistic cytotoxic effects against breast cancer cell line MDA-MB-231 in vitro
    Chin Med (2016) 11, 46-46. PubMed  Europe PubMed DOI  PMC  EPMC  U
  83. Rathnavelu,V., Alitheen,N.B., Sohila,S., Kanagesan,S. and Ramesh,R.
    Potential role of bromelain in clinical and therapeutic applications
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