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Literature for peptidase A28.001: DNA-damage inducible protein 1

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Inhibitors

(Topics flags: S Structure, T Target, I Inhibitor. To select only the references relevant to a single topic, click the link above. See explanation.)

    2026
  1. Minard,A.Y., Winistorfer,S., Yu,L. and Piper,R.C.
    K48-ubiquitin-dependent proteases cut-up post-ER proteins
    Nat Commun (2026) PubMed  Europe PubMed DOI
    2. 2025
  2. Sukted,J., Junsuntonpass,A., Homchan,A., Mongkolsuk,S., Pakotiprapha,D. and Matangkasombut,O.
    Wss1 and Ddi1 DNA-Protein crosslink repair proteases protect Saccharomyces cerevisiae and Candida albicans against oxidative stress
    Sci Rep (2025) 15, 26758-26758. PubMed  Europe PubMed DOI  PMC  EPMC
    3. 2024
  3. Conti,B.A., Ruiz,P.D., Broton,C., Blobel,N.J., Kottemann,M.C., Sridhar,S., Lach,F.P., Wiley,T.F., Sasi,N.K., Carroll,T. and Smogorzewska,A.
    RTF2 controls replication repriming and ribonucleotide excision at the replisome
    Nat Commun (2024) 15, 1943-1943. PubMed  Europe PubMed DOI  PMC  EPMC
  4. Fabijan,A., Polis,B., Zawadzka-Fabijan,A., Korabiewska,I., Zakrzewski,K., Nowoslawska,E. and Chojnacki,M.
    Domains in Action: Understanding Ddi1's Diverse Functions in the Ubiquitin-Proteasome System
    Int J Mol Sci (2024) 25 PubMed  Europe PubMed DOI  PMC  EPMC
  5. Waite,K.A., Vontz,G., Lee,S.Y. and Roelofs,J.
    Proteasome condensate formation is driven by multivalent interactions with shuttle factors and ubiquitin chains
    Proc Natl Acad Sci U S A (2024) 121, e2310756121-e2310756121. PubMed  Europe PubMed DOI  PMC  EPMC
    6. 2020
  6. El Dika,M.
    New insights into the regulation of DNA-protein crosslink repair by the aspartic protease Ddi1 in yeast
    DNA Repair (Amst) (2020) 90, 102854-102854. PubMed  Europe PubMed DOI
  7. Motyan,J.A., Miczi,M. and Tozser,J.
    Dimer interface organization is a main determinant of intermonomeric interactions and correlates with evolutionary relationships of retroviral and retroviral-like Ddi1 and Ddi2 proteases
    Int J Mol Sci (2020) 21 PubMed  Europe PubMed DOI
  8. Serbyn,N., Noireterre,A., Bagdiul,I., Plank,M., Michel,A.H., Loewith,R., Kornmann,B. and Stutz,F.
    The aspartic protease Ddi1 contributes to DNA-protein crosslink repair in yeast
    Mol Cell (2020) 77, 1066-1079. PubMed  Europe PubMed DOI
  9. Spasskaya,D.S., Nadolinskaia,N.I., Tutyaeva,V.V., Lysov,Y.P., Karpov,V.L. and Karpov,D.S.
    Yeast Rpn4 Links the Proteasome and DNA Repair via RAD52 Regulation
    Int J Mol Sci (2020) 21 PubMed  Europe PubMed DOI  PMC  EPMC
  10. Suo,D., Wang,L., Zeng,T., Zhang,H., Li,L., Liu,J., Yun,J., Guan,X.Y. and Li,Y.
    NRIP3 upregulation confers resistance to chemoradiotherapy in ESCC via RTF2 removal by accelerating ubiquitination and degradation of RTF2
    Oncogenesis (2020) 9, 75-75. PubMed  Europe PubMed DOI  PMC  EPMC
  11. Yip,M.C.J., Bodnar,N.O. and Rapoport,T.A.
    Ddi1 is a ubiquitin-dependent protease
    Proc Natl Acad Sci U S A (2020) 117, 7776-7781. PubMed  Europe PubMed DOI
    12. 2019
  12. Chen,X., Ebelle,D.L., Wright,B.J., Sridharan,V., Hooper,E. and Walters,K.J.
    Structure of hRpn10 bound to UBQLN2 UBL illustrates basis for complementarity between shuttle factors and substrates at the proteasome
    J Mol Biol (2019) 431, 939-955. PubMed  Europe PubMed DOI  S
  13. Svoboda,M., Konvalinka,J., Trempe,J.F. and Grantz Saskova,K.
    The yeast proteases Ddi1 and Wss1 are both involved in the DNA replication stress response
    DNA Repair (Amst) (2019) 80, 45-51. PubMed  Europe PubMed DOI
    14. 2018
  14. Bouvier,L.A., Niemirowicz,G.T., Salas-Sarduy,E., Cazzulo,J.J. and Alvarez,V.E.
    DNA-damage inducible protein 1 is a conserved metacaspase substrate that is cleaved and further destabilized in yeast under specific metabolic conditions
    FEBS J (2018) 285, 1097-1110. PubMed  Europe PubMed DOI
  15. Kumar,S. and Suguna,K.
    Crystal structure of the retroviral protease-like domain of a protozoal DNA damage-inducible 1 protein
    FEBS Open Bio (2018) 8, 1379-1394. PubMed  Europe PubMed DOI  PMC  EPMC  S
  16. Onchieku,N.M., Mogire,R., Ndung'u,L., Mwitari,P., Kimani,F., Matoke-Muhia,D., Kiboi,D. and Magoma,G.
    Deciphering the targets of retroviral protease inhibitors in Plasmodium berghei
    PLoS ONE (2018) 13, e0201556-e0201556. PubMed  Europe PubMed DOI  PMC  EPMC  I
  17. Xiang,Y., Halin,J., Fan,Z., Hu,S., Wang,M., Qiu,L., Zhang,Z., Mattjus,P. and Zhang,Y.
    Topovectorial mechanisms control the juxtamembrane proteolytic processing of Nrf1 to remove its N-terminal polypeptides during maturation of the CNC-bZIP factor
    Toxicol Appl Pharmacol (2018) 360, 160-184. PubMed  Europe PubMed DOI
    18. 2017
  18. Oh,K.H., Haney,J.J., Wang,X., Chuang,C.F., Richmond,J.E. and Kim,H.
    ERG-28 controls BK channel trafficking in the ER to regulate synaptic function and alcohol response in C. elegans
    elife (2017) 6 PubMed  Europe PubMed DOI  PMC  EPMC
    19. 2016
  19. Lehrbach,N.J. and Ruvkun,G.
    Proteasome dysfunction triggers activation of SKN-1A/Nrf1 by the aspartic protease DDI-1
    elife (2016) 5 PubMed  Europe PubMed DOI  PMC  EPMC  T
  20. Sha,Z. and Goldberg,A.L.
    Reply to Vangala et al.: Complete inhibition of the proteasome reduces new proteasome production by causing Nrf1 aggregation
    Curr Biol (2016) 26, R836-R836. PubMed  Europe PubMed DOI
  21. Trempe,J.F., Saskova,K.G., Siva,M., Ratcliffe,C.D., Veverka,V., Hoegl,A., Menade,M., Feng,X., Shenker,S., Svoboda,M., Kozisek,M., Konvalinka,J. and Gehring,K.
    Structural studies of the yeast DNA damage-inducible protein Ddi1 reveal domain architecture of this eukaryotic protein family
    Sci Rep (2016) 6, 33671-33671. PubMed  Europe PubMed DOI  PMC  EPMC  S
    22. 2015
  22. Nowicka,U., Zhang,D., Walker,O., Krutauz,D., Castaneda,C.A., Chaturvedi,A., Chen,T.Y., Reis,N., Glickman,M.H. and Fushman,D.
    DNA-damage-inducible 1 protein (Ddi1) contains an uncharacteristic ubiquitin-like domain that binds ubiquitin
    Structure (2015) 23, 542-557. PubMed  Europe PubMed DOI
    23. 2013
  23. Perteguer,M.J., Gomez-Puertas,P., Canavate,C., Dagger,F., Garate,T. and Valdivieso,E.
    Ddi1-like protein from Leishmania major is an active aspartyl proteinase
    Cell Stress Chaperones (2013) 18, 171-181. PubMed  Europe PubMed DOI
    24. 2012
  24. Berry,C.
    Ddi1 and related proteins
    [ISSN:978-0-12-407744-7] (2012) 3, 255-258. DOI
    25. 2011
  25. Morawe,T., Honemann-Capito,M., von Stein,W. and Wodarz,A.
    Loss of the extraproteasomal ubiquitin receptor Rings lost impairs ring canal growth in Drosophila oogenesis
    J Cell Biol (2011) 193, 71-80. PubMed  Europe PubMed DOI
  26. White,R.E., Dickinson,J.R., Semple,C.A., Powell,D.J. and Berry,C.
    The retroviral proteinase active site and the N-terminus of Ddi1 are required for repression of protein secretion
    FEBS Lett (2011) 585, 139-142. PubMed  Europe PubMed DOI
  27. White,R.E., Powell,D.J. and Berry,C.
    HIV proteinase inhibitors target the Ddi1-like protein of Leishmania parasites
    FASEB J (2011) 25, 1729-1736. PubMed  Europe PubMed DOI
    28. 2008
  28. Auesukaree,C., Fuchigami,I., Homma,T., Kaneko,Y. and Harashima,S.
    Ddi1p and Rad23p play a cooperative role as negative regulators in the PHO pathway in Saccharomyces cerevisiae
    Biochem Biophys Res Commun (2008) 365, 821-825. PubMed  Europe PubMed DOI
  29. Gabriely,G., Kama,R., Gelin-Licht,R. and Gerst,J.E.
    Different domains of the UBL-UBA ubiquitin receptor, Ddi1/Vsm1, are involved in its multiple cellular roles
    Mol Biol Cell (2008) 19, 3625-3637. PubMed  Europe PubMed DOI  PMC  EPMC
    30. 2006
  30. Diaz-Martinez,L.A., Kang,Y., Walters,K.J. and Clarke,D.J.
    Yeast UBL-UBA proteins have partially redundant functions in cell cycle control
    Cell Div (2006) 1, 28-28. PubMed  Europe PubMed DOI  PMC  EPMC
  31. Ivantsiv,Y., Kaplun,L., Tzirkin-Goldin,R., Shabek,N. and Raveh,D.
    Unique role for the UbL-UbA protein Ddi1 in turnover of SCFUfo1 complexes
    Mol Cell Biol (2006) 26, 1579-1588. PubMed  Europe PubMed DOI  PMC  EPMC
  32. [YEAR:3-9-2006]Sirkis,R., Gerst,J.E. and Fass,D.
    Ddi1, a eukaryotic protein with the retroviral protease fold
    J Mol Biol (3-9-2006) 364, 376-387. PubMed  Europe PubMed DOI  S
    33. 2005
  33. Kaplun,L., Tzirkin,R., Bakhrat,A., Shabek,N., Ivantsiv,Y. and Raveh,D.
    The DNA damage-inducible UbL-UbA protein Ddi1 participates in Mec1-mediated degradation of Ho endonuclease
    Mol Cell Biol (2005) 25, 5355-5362. PubMed  Europe PubMed DOI  PMC  EPMC
    34. 2001
  34. Bertolaet,B.L., Clarke,D.J., Wolff,M., Watson,M.H., Henze,M., Divita,G. and Reed,S.I.
    UBA domains of DNA damage-inducible proteins interact with ubiquitin
    Nat Struct Biol (2001) 8, 417-422. PubMed  Europe PubMed DOI
  35. [YEAR:7-8-2001]Krylov,D.M. and Koonin,E.V.
    A novel family of predicted retroviral-like aspartyl proteases with a possible key role in eukaryotic cell cycle control
    Curr Biol (7-8-2001) 11, R584-R587. PubMed  Europe PubMed
    36. 1999
  36. Lustgarten,V. and Gerst,J.E.
    Yeast VSM1 encodes a v-SNARE binding protein that may act as a negative regulator of constitutive exocytosis
    Mol Cell Biol (1999) 19, 4480-4494. PubMed  Europe PubMed  PMC  EPMC
    37. 1997
  37. Liu,Y. and Xiao,W.
    Bidirectional regulation of two DNA-damage-inducible genes, MAG1 and DDI1, from Saccharomyces cerevisiae
    Mol Microbiol (1997) 23, 777-789. PubMed  Europe PubMed

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