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Literature for peptidase A26.003: plasminogen activator Pla

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

(Topics flags: S Structure, P Specificity, K Knockout, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Appell,K.T., Guo,W., Scott,M., Blevins,J.S. and Pechous,R.D.
    Yersinia pestis plasminogen activator protease is regulated by the PhoP/PhoQ two-component system
    J Bacteriol (2025) , e0035725-e0035725. PubMed  Europe PubMed DOI
    2. 2024
  2. Ge,B., Hu,C., Qian,Y., Tang,Y., Zhang,Q., Jiang,S., Mu,Z. and Zhang,M.
    Sinensetin interferes with Staphylococcus aureus infections by targeting staphylocoagulase and improves infection survival rates in mouse model of pneumonia
    J Appl Microbiol (2024) 135 PubMed  Europe PubMed DOI
    3. 2023
  3. Theriot,H.M., Malaviarachchi,P.A., Scott,M.G., Appell,K.T., Banerjee,S.K. and Pechous,R.D.
    Pulmonary Expression of Interleukin-17 Contributes to Neutrophil Infiltration into the Lungs during Pneumonic Plague
    Infect Immun (2023) 91, e0013123-e0013123. PubMed  Europe PubMed DOI  PMC  EPMC
    4. 2020
  4. Banerjee,S.K., Crane,S.D. and Pechous,R.D.
    A dual role for the plasminogen activator protease during the pre-inflammatory phase of primary pneumonic plague
    J Infect Dis (2020) PubMed  Europe PubMed DOI
  5. Krukonis,E.S. and Thomson,J.J.
    Complement evasion mechanisms of the systemic pathogens Yersiniae and Salmonellae
    FEBS Lett (2020) PubMed  Europe PubMed DOI
  6. Sebbane,F., Uversky,V.N. and Anisimov,A.P.
    Yersinia pestis Plasminogen Activator
    Biomolecules (2020) 10 PubMed  Europe PubMed DOI  PMC  EPMC
    7. 2019
  7. Banerjee,S.K., Huckuntod,S.D., Mills,S.D., Kurten,R.C. and Pechous,R.D.
    Modeling pneumonic plague in human precision-cut lung slices highlights a role for the plasminogen activating protease in facilitating type 3 secretion
    Infect Immun (2019) 87, e00175-19-e00175-19. PubMed  Europe PubMed DOI
  8. Feodorova,V.A., Lyapina,A.M., Zaitsev,S.S., Khizhnyakova,M.A., Sayapina,L.V., Ulianova,O.V., Ulyanov,S.S. and Motin,V.L.
    New promising targets for synthetic omptin-based peptide vaccine against Gram-negative pathogens
    Vaccines (Basel) (2019) 7 PubMed  Europe PubMed DOI
  9. Smiley,S.T., Szaba,F.M., Kummer,L.W., Duso,D.K. and Lin,J.S.
    Yersinia pestis Pla protein thwarts T cell defense against plague
    Infect Immun (2019) 87, e00126-19-e00126-19. PubMed  Europe PubMed DOI
    10. 2016
  10. Dentovskaya,S.V., Platonov,M.E., Svetoch,T.E., Kopylov,P.K., Kombarova,T.I., Ivanov,S.A., Shaikhutdinova,R.Z., Kolombet,L.V., Chauhan,S., Ablamunits,V.G., Motin,V.L., Uversky,V.N. and Anisimov,A.P.
    Two isoforms of Yersinia pestis plasminogen activator Pla: intraspecies distribution, intrinsic disorder propensity, and contribution to virulence
    PLoS ONE (2016) 11, e0168089-e0168089. PubMed  Europe PubMed DOI
    11. 2015
  11. Brannon,J.R., Burk,D.L., Leclerc,J.M., Thomassin,J.L., Portt,A., Berghuis,A.M., Gruenheid,S. and Le Moual,H.
    Inhibition of outer membrane proteases of the omptin family by aprotinin
    Infect Immun (2015) 83, 2300-2311. PubMed  Europe PubMed DOI
  12. Eddy,J.L., Schroeder,J.A., Zimbler,D.L., Bellows,L.E. and Lathem,W.W.
    Impact of the Pla protease substrate alpha2-antiplasmin on the progression of primary pneumonic plague
    Infect Immun (2015) 83, 4837-4847. PubMed  Europe PubMed DOI
  13. Guinet,F., Ave,P., Filali,S., Huon,C., Savin,C., Huerre,M., Fiette,L. and Carniel,E.
    Dissociation of tissue destruction and bacterial expansion during bubonic plague
    PLoS Pathog (2015) 11, e1005222-e1005222. PubMed  Europe PubMed DOI  PMC  EPMC
  14. Korhonen,T.K.
    Fibrinolytic and procoagulant activities of Yersinia pestis and Salmonella enterica
    J Thromb Haemost (2015) 13 Suppl 1, S115-S120. PubMed  Europe PubMed DOI
  15. van Lier,C.J., Tiner,B.L., Chauhan,S., Motin,V.L., Fitts,E.C., Huante,M.B., Endsley,J.J., Ponnusamy,D., Sha,J. and Chopra,A.K.
    Further characterization of a highly attenuated Yersinia pestis CO92 mutant deleted for the genes encoding Braun lipoprotein and plasminogen activator protease in murine alveolar and primary human macrophages
    Microb Pathog (2015) 80C, 27-38. PubMed  Europe PubMed DOI  K
  16. Zimbler,D.L., Eddy,J.L., Schroeder,J.A. and Lathem,W.W.
    Inactivation of peroxiredoxin 6 by the Pla protease of Yersinia pestis
    Infect Immun (2015) 84, 365-374. PubMed  Europe PubMed DOI
    17. 2014
  17. Caulfield,A.J., Walker,M.E., Gielda,L.M. and Lathem,W.W.
    The Pla protease of Yersinia pestis degrades Fas ligand to manipulate host cell death and inflammation
    Cell Host Microbe (2014) 15, 424-434. PubMed  Europe PubMed DOI
  18. van Lier,C.J., Sha,J., Kirtley,M.L., Cao,A., Tiner,B.L., Erova,T.E., Cong,Y., Kozlova,E.V., Popov,V.L., Baze,W.B. and Chopra,A.K.
    Deletion of Braun lipoprotein and plasminogen-activating protease-encoding genes attenuates Yersinia pestis in mouse models of bubonic and pneumonic plague
    Infect Immun (2014) 82, 2485-2503. PubMed  Europe PubMed DOI
    19. 2013
  19. Jarvinen,H.M., Laakkonen,L., Haiko,J., Johansson,T., Juuti,K., Suomalainen,M., Buchrieser,C., Kalkkinen,N. and Korhonen,T.K.
    Human single-chain urokinase is activated by the omptins PgtE of Salmonella enterica and Pla of Yersinia pestis despite mutations of active site residues
    Mol Microbiol (2013) 89, 507-517. PubMed  Europe PubMed DOI
  20. Korhonen,T.K., Haiko,J., Laakkonen,L., Jarvinen,H.M. and Westerlund-Wikstrom,B.
    Fibrinolytic and coagulative activities of Yersinia pestis
    Front Cell Infect Microbiol (2013) 3, 35-35. PubMed  Europe PubMed DOI  PMC  EPMC
  21. Lane,M.C., Lenz,J.D. and Miller,V.L.
    Proteolytic processing of the Yersinia pestis YapG autotransporter by the omptin protease Pla and the contribution of YapG to murine plague pathogenesis
    J Med Microbiol (2013) 62, 1124-1134. PubMed  Europe PubMed DOI
  22. Lawrenz,M.B., Pennington,J. and Miller,V.L.
    Acquisition of omptin reveals cryptic virulence function of autotransporter YapE in Yersinia pestis
    Mol Microbiol (2013) 89, 276-287. PubMed  Europe PubMed DOI
  23. Ruback,E., Lobo,L.A., Franca,T.C. and Pascutti,P.G.
    Structural analysis of Pla protein from the biological warfare agent Yersinia pestis: docking and molecular dynamics of interactions with the mammalian plasminogen system
    J Biomol Struct Dyn (2013) 31, 477-484. PubMed  Europe PubMed DOI
    24. 2012
  24. Caulfield,A.J. and Lathem,W.W.
    Substrates of the plasminogen activator protease of Yersinia pestis
    Adv Exp Med Biol (2012) 954, 253-260. PubMed  Europe PubMed DOI
  25. Eren,E. and van den Berg,B.
    Structural basis for activation of an integral membrane protease by lipopolysaccharide
    J Biol Chem (2012) 287, 23971-23976. PubMed  Europe PubMed DOI  S
  26. Guinet,F. and Carniel,E.
    Impact on the host of the Yersinia pestis-specific virulence set and the contribution of the Pla surface protease
    Adv Exp Med Biol (2012) 954, 211-216. PubMed  Europe PubMed DOI
  27. Haiko,J., Korhonen,T.K. and Laakkonen,L.
    Plasminogen activator of Yersinia pestis
    [ISSN:978-0-12-407744-7] (2012) 3, 289-293. DOI
    28. 2011
  28. Haiko,J., Laakkonen,L., Westerlund-Wikstrom,B. and Korhonen,T.K.
    Molecular adaptation of a plant-bacterium outer membrane protease towards plague virulence factor Pla
    BMC Evol Biol (2011) 11, 43-43. PubMed  Europe PubMed DOI
    29. 2010
  29. Eren,E., Murphy,M., Goguen,J. and van den Berg,B.
    An active site water network in the plasminogen activator pla from Yersinia pestis
    Structure (2010) 18, 809-818. PubMed  Europe PubMed DOI  S
  30. Haiko,J., Laakkonen,L., Juuti,K., Kalkkinen,N. and Korhonen,T.K.
    The omptins of Yersinia pestis and Salmonella enterica cleave the reactive center loop of plasminogen activator inhibitor 1
    J Bacteriol (2010) 192, 4553-4561. PubMed  Europe PubMed DOI  P
  31. Suomalainen,M., Lobo,L.A., Brandenburg,K., Lindner,B., Virkola,R., Knirel,Y.A., Anisimov,A.P., Holst,O. and Korhonen,T.K.
    Temperature-induced changes in the lipopolysaccharide of Yersinia pestis affect plasminogen activation by the Pla surface protease
    Infect Immun (2010) 78, 2644-2652. PubMed  Europe PubMed DOI
  32. Valls Seron,M., Haiko,J., DE Groot,P.G., Korhonen,T.K. and Meijers,J.C.
    Thrombin-activatable fibrinolysis inhibitor is degraded by Salmonella enterica and Yersinia pestis
    J Thromb Haemost (2010) 8, 2232-2240. PubMed  Europe PubMed DOI
    33. 2009
  33. Haiko,J., Suomalainen,M., Ojala,T., Lahteenmaki,K. and Korhonen,T.K.
    Invited review: Breaking barriers - attack on innate immune defences by omptin surface proteases of enterobacterial pathogens
    Innate Immun (2009) 15, 67-80. PubMed  Europe PubMed DOI
  34. Haiko,J., Kukkonen,M., Ravantti,J.J., Westerlund-Wikstrom,B. and Korhonen,T.K.
    The single substitution I259T, conserved in the plasminogen activator Pla of pandemic Yersinia pestis branches, enhances fibrinolytic activity
    J Bacteriol (2009) 191, 4758-4766. PubMed  Europe PubMed DOI  PMC  EPMC
    35. 2008
  35. Agarkov,A., Chauhan,S., Lory,P.J., Gilbertson,S.R. and Motin,V.L.
    Substrate specificity and screening of the integral membrane protease Pla
    Bioorg Med Chem Lett (2008) 18, 427-431. PubMed  Europe PubMed DOI  PMC  EPMC  P
  36. Galvan,E.M., Lasaro,M.A. and Schifferli,D.M.
    Capsular antigen fraction 1 and Pla modulate the susceptibility of Yersinia pestis to pulmonary antimicrobial peptides such as cathelicidin
    Infect Immun (2008) 76, 1456-1464. PubMed  Europe PubMed DOI  PMC  EPMC
  37. Zhang,S.S., Park,C.G., Zhang,P., Bartra,S.S., Plano,G.V., Klena,J.D., Skurnik,M., Hinnebusch,B.J. and Chen,T.
    Plasminogen activator Pla of Yersinia pestis utilizes murine DEC-205 (CD205) as a receptor to promote dissemination
    J Biol Chem (2008) 283, 31511-31521. PubMed  Europe PubMed DOI  PMC  EPMC
    38. 2007
  38. [YEAR:26-1-2007]Lathem,W.W., Price,P.A., Miller,V.L. and Goldman,W.E.
    A plasminogen-activating protease specifically controls the development of primary pneumonic plague
    Science (26-1-2007) 315, 509-513. PubMed  Europe PubMed DOI
  39. Suomalainen,M., Haiko,J., Ramu,P., Lobo,L., Kukkonen,M., Westerlund-Wikstrom,B., Virkola,R., Lahteenmaki,K. and Korhonen,T.K.
    Using every trick in the book: the Pla surface protease of Yersinia pestis
    Adv Exp Med Biol (2007) 603, 268-278. PubMed  Europe PubMed DOI  V
    40. 2006
  40. Lobo,L.A.
    Adhesive properties of the purified plasminogen activator Pla of Yersinia pestis
    FEMS Microbiol Lett (2006) 262, 158-162. PubMed  Europe PubMed DOI
  41. Sebbane,F., Jarrett,C.O., Gardner,D., Long,D. and Hinnebusch,B.J.
    Role of the Yersinia pestis plasminogen activator in the incidence of distinct septicemic and bubonic forms of flea-borne plague
    Proc Natl Acad Sci U S A (2006) 103, 5526-5530. PubMed  Europe PubMed DOI  PMC  EPMC
    42. 2004
  42. Korhonen,T.K., Lahteenmaki,K., Kukkonen,M. and Lang,H.
    Plasminogen activator of Yersinia pestis
    [ISSN:0-12-079610-4] (2004) 2, 217-219.  V
  43. Kukkonen,M. and Korhonen,T.K.
    The omptin family of enterobacterial surface proteases/adhesins: from housekeeping in Escherichia coli to systemic spread of Yersinia pestis
    Int J Med Microbiol (2004) 294, 7-14. PubMed  Europe PubMed DOI
  44. Kukkonen,M., Suomalainen,M., Kyllonen,P., Lahteenmaki,K., Lang,H., Virkola,R., Helander,I.M., Holst,O. and Korhonen,T.K.
    Lack of O-antigen is essential for plasminogen activation by Yersinia pestis and Salmonella enterica
    Mol Microbiol (2004) 51, 215-225. PubMed  Europe PubMed DOI
    45. 2001
  45. Kukkonen,M., Lahteenmaki,K., Suomalainen,M., Kalkkinen,N., Emody,L., Lang,H. and Korhonen,T.K.
    Protein regions important for plasminogen activation and inactivation of alpha2-antiplasmin in the surface protease Pla of Yersinia pestis
    Mol Microbiol (2001) 40, 1097-1111. PubMed  Europe PubMed DOI
  46. Lahteenmaki,K., Kukkonen,M. and Korhonen,T.K.
    The Pla surface protease/adhesin of Yersinia pestis mediates bacterial invasion into human endothelial cells
    FEBS Lett (2001) 504, 69-72. PubMed  Europe PubMed DOI
    47. 2000
  47. Cowan,C., Jones,H.A., Kaya,Y.H., Perry,R.D. and Straley,S.C.
    Invasion of epithelial cells by Yersinia pestis: evidence for a Y. pestis-specific invasin
    Infect Immun (2000) 68, 4523-4530. PubMed  Europe PubMed DOI  PMC  EPMC
    48. 1999
  48. Kutyrev,V., Mehigh,R.J., Motin,V.L., Pokrovskaya,M.S., Smirnov,G.B. and Brubaker,R.R.
    Expression of the plague plasminogen activator in Yersinia pseudotuberculosis and Escherichia coli
    Infect Immun (1999) 67, 1359-1367. PubMed  Europe PubMed  PMC  EPMC
    49. 1998
  49. Hinnebusch,B.J., Fischer,E.R. and Schwan,T.G.
    Evaluation of the role of the Yersinia pestis plasminogen activator and other plasmid-encoded factors in temperature-dependent blockage of the flea
    J Infect Dis (1998) 178, 1406-1415. PubMed  Europe PubMed
  50. Lahteenmaki,K., Virkola,R., Saren,A., Emody,L. and Korhonen,T.K.
    Expression of plasminogen activator pla of Yersinia pestis enhances bacterial attachment to the mammalian extracellular matrix
    Infect Immun (1998) 66, 5755-5762. PubMed  Europe PubMed  PMC  EPMC
    51. 1997
  51. Welkos,S.L., Friedlander,A.M. and Davis,K.J.
    Studies on the role of plasminogen activator in systemic infection by virulent Yersinia pestis strain C092
    Microb Pathog (1997) 23, 211-223. PubMed  Europe PubMed DOI
    52. 1995
  52. Easterbrook,T.J., Reddin,K., Robinson,A. and Modi,N.
    Studies on the immunogenicity of the Pla protein from Yersinia pestis
    Contrib Microbiol Immunol (1995) 13, 214-215. PubMed  Europe PubMed
    53. 1993
  53. McDonough,K.A., Barnes,A.M., Quan,T.J., Montenieri,J. and Falkow,S.
    Mutation in the pla gene of Yersinia pestis alters the course of the plague bacillus-flea (Siphonaptera: Ceratophyllidae) interaction
    J Med Entomol (1993) 30, 772-780. PubMed  Europe PubMed
    54. 1992
  54. [YEAR:6-11-1992]Sodeinde,O.A., Subrahmanyam,Y.V., Stark,K., Quan,T., Bao,Y. and Goguen,J.D.
    A surface protease and the invasive character of plague
    Science (6-11-1992) 258, 1004-1007. PubMed  Europe PubMed
    55. 1989
  55. McDonough,K.A. and Falkow,S.
    A Yersinia pestis-specific DNA fragment encodes temperature-dependent coagulase and fibrinolysin-associated phenotypes
    Mol Microbiol (1989) 3, 767-775. PubMed  Europe PubMed
  56. Sodeinde,O.A. and Goguen,J.D.
    Nucleotide sequence of the plasminogen activator gene of Yersinia pestis: relationship to ompT of Escherichia coli and gene E of Salmonella typhimurium
    Infect Immun (1989) 57, 1517-1523. PubMed  Europe PubMed  PMC  EPMC
    57. 1988
  57. Sodeinde,O.A., Sample,A.K., Brubaker,R.R. and Goguen,J.D.
    Plasminogen activator/coagulase gene of Yersinia pestis is responsible for degradation of plasmid-encoded outer membrane proteins
    Infect Immun (1988) 56, 2749-2752. PubMed  Europe PubMed  PMC  EPMC
  58. Sodeinde,O.A. and Goguen,J.D.
    Genetic analysis of the 9.5-kilobase virulence plasmid of Yersinia pestis
    Infect Immun (1988) 56, 2743-2748. PubMed  Europe PubMed  PMC  EPMC
    59. 1967
  59. Beesley,E.D., Brubaker,R.R., Janssen,W.A. and Surgalla,M.J.
    Pesticins. 3. Expression of coagulase and mechanism of fibrinolysis
    J Bacteriol (1967) 94, 19-26. PubMed  Europe PubMed  PMC  EPMC

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