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Literature for peptidase A26.003: plasminogen activator Pla

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

(Topics flags: S Structure, P Specificity, K Knockout, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Appell,K.T., Guo,W., Scott,M., Blevins,J.S. and Pechous,R.D.<br>Yersinia pestis plasminogen activator protease is regulated by the PhoP/PhoQ two-component system<br>J Bacteriol (2025) , e0035725-e0035725. PubMed  Europe PubMed DOI
    2. 2024
  2. Ge,B., Hu,C., Qian,Y., Tang,Y., Zhang,Q., Jiang,S., Mu,Z. and Zhang,M.<br>Sinensetin interferes with Staphylococcus aureus infections by targeting staphylocoagulase and improves infection survival rates in mouse model of pneumonia<br>J Appl Microbiol (2024) 135 PubMed  Europe PubMed DOI
    3. 2023
  3. Theriot,H.M., Malaviarachchi,P.A., Scott,M.G., Appell,K.T., Banerjee,S.K. and Pechous,R.D.<br>Pulmonary Expression of Interleukin-17 Contributes to Neutrophil Infiltration into the Lungs during Pneumonic Plague<br>Infect Immun (2023) 91, e0013123-e0013123. PubMed  Europe PubMed DOI  PMC  EPMC
    4. 2020
  4. Banerjee,S.K., Crane,S.D. and Pechous,R.D.<br>A dual role for the plasminogen activator protease during the pre-inflammatory phase of primary pneumonic plague<br>J Infect Dis (2020) PubMed  Europe PubMed DOI
  5. Krukonis,E.S. and Thomson,J.J.<br>Complement evasion mechanisms of the systemic pathogens Yersiniae and Salmonellae<br>FEBS Lett (2020) PubMed  Europe PubMed DOI
  6. Sebbane,F., Uversky,V.N. and Anisimov,A.P.<br>Yersinia pestis Plasminogen Activator<br>Biomolecules (2020) 10 PubMed  Europe PubMed DOI  PMC  EPMC
    7. 2019
  7. Banerjee,S.K., Huckuntod,S.D., Mills,S.D., Kurten,R.C. and Pechous,R.D.<br>Modeling pneumonic plague in human precision-cut lung slices highlights a role for the plasminogen activating protease in facilitating type 3 secretion<br>Infect Immun (2019) 87, e00175-19-e00175-19. PubMed  Europe PubMed DOI
  8. Feodorova,V.A., Lyapina,A.M., Zaitsev,S.S., Khizhnyakova,M.A., Sayapina,L.V., Ulianova,O.V., Ulyanov,S.S. and Motin,V.L.<br>New promising targets for synthetic omptin-based peptide vaccine against Gram-negative pathogens<br>Vaccines (Basel) (2019) 7 PubMed  Europe PubMed DOI
  9. Smiley,S.T., Szaba,F.M., Kummer,L.W., Duso,D.K. and Lin,J.S.<br>Yersinia pestis Pla protein thwarts T cell defense against plague<br>Infect Immun (2019) 87, e00126-19-e00126-19. PubMed  Europe PubMed DOI
    10. 2016
  10. Dentovskaya,S.V., Platonov,M.E., Svetoch,T.E., Kopylov,P.K., Kombarova,T.I., Ivanov,S.A., Shaikhutdinova,R.Z., Kolombet,L.V., Chauhan,S., Ablamunits,V.G., Motin,V.L., Uversky,V.N. and Anisimov,A.P.<br>Two isoforms of Yersinia pestis plasminogen activator Pla: intraspecies distribution, intrinsic disorder propensity, and contribution to virulence<br>PLoS ONE (2016) 11, e0168089-e0168089. PubMed  Europe PubMed DOI
    11. 2015
  11. Brannon,J.R., Burk,D.L., Leclerc,J.M., Thomassin,J.L., Portt,A., Berghuis,A.M., Gruenheid,S. and Le Moual,H.<br>Inhibition of outer membrane proteases of the omptin family by aprotinin<br>Infect Immun (2015) 83, 2300-2311. PubMed  Europe PubMed DOI
  12. Eddy,J.L., Schroeder,J.A., Zimbler,D.L., Bellows,L.E. and Lathem,W.W.<br>Impact of the Pla protease substrate alpha2-antiplasmin on the progression of primary pneumonic plague<br>Infect Immun (2015) 83, 4837-4847. PubMed  Europe PubMed DOI
  13. Guinet,F., Ave,P., Filali,S., Huon,C., Savin,C., Huerre,M., Fiette,L. and Carniel,E.<br>Dissociation of tissue destruction and bacterial expansion during bubonic plague<br>PLoS Pathog (2015) 11, e1005222-e1005222. PubMed  Europe PubMed DOI  PMC  EPMC
  14. Korhonen,T.K.<br>Fibrinolytic and procoagulant activities of Yersinia pestis and Salmonella enterica<br>J Thromb Haemost (2015) 13 Suppl 1, S115-S120. PubMed  Europe PubMed DOI
  15. van Lier,C.J., Tiner,B.L., Chauhan,S., Motin,V.L., Fitts,E.C., Huante,M.B., Endsley,J.J., Ponnusamy,D., Sha,J. and Chopra,A.K.<br>Further characterization of a highly attenuated Yersinia pestis CO92 mutant deleted for the genes encoding Braun lipoprotein and plasminogen activator protease in murine alveolar and primary human macrophages<br>Microb Pathog (2015) 80C, 27-38. PubMed  Europe PubMed DOI  K
  16. Zimbler,D.L., Eddy,J.L., Schroeder,J.A. and Lathem,W.W.<br>Inactivation of peroxiredoxin 6 by the Pla protease of Yersinia pestis<br>Infect Immun (2015) 84, 365-374. PubMed  Europe PubMed DOI
    17. 2014
  17. Caulfield,A.J., Walker,M.E., Gielda,L.M. and Lathem,W.W.<br>The Pla protease of Yersinia pestis degrades Fas ligand to manipulate host cell death and inflammation<br>Cell Host Microbe (2014) 15, 424-434. PubMed  Europe PubMed DOI
  18. van Lier,C.J., Sha,J., Kirtley,M.L., Cao,A., Tiner,B.L., Erova,T.E., Cong,Y., Kozlova,E.V., Popov,V.L., Baze,W.B. and Chopra,A.K.<br>Deletion of Braun lipoprotein and plasminogen-activating protease-encoding genes attenuates Yersinia pestis in mouse models of bubonic and pneumonic plague<br>Infect Immun (2014) 82, 2485-2503. PubMed  Europe PubMed DOI
    19. 2013
  19. Jarvinen,H.M., Laakkonen,L., Haiko,J., Johansson,T., Juuti,K., Suomalainen,M., Buchrieser,C., Kalkkinen,N. and Korhonen,T.K.<br>Human single-chain urokinase is activated by the omptins PgtE of Salmonella enterica and Pla of Yersinia pestis despite mutations of active site residues<br>Mol Microbiol (2013) 89, 507-517. PubMed  Europe PubMed DOI
  20. Korhonen,T.K., Haiko,J., Laakkonen,L., Jarvinen,H.M. and Westerlund-Wikstrom,B.<br>Fibrinolytic and coagulative activities of Yersinia pestis<br>Front Cell Infect Microbiol (2013) 3, 35-35. PubMed  Europe PubMed DOI  PMC  EPMC
  21. Lane,M.C., Lenz,J.D. and Miller,V.L.<br>Proteolytic processing of the Yersinia pestis YapG autotransporter by the omptin protease Pla and the contribution of YapG to murine plague pathogenesis<br>J Med Microbiol (2013) 62, 1124-1134. PubMed  Europe PubMed DOI
  22. Lawrenz,M.B., Pennington,J. and Miller,V.L.<br>Acquisition of omptin reveals cryptic virulence function of autotransporter YapE in Yersinia pestis<br>Mol Microbiol (2013) 89, 276-287. PubMed  Europe PubMed DOI
  23. Ruback,E., Lobo,L.A., Franca,T.C. and Pascutti,P.G.<br>Structural analysis of Pla protein from the biological warfare agent Yersinia pestis: docking and molecular dynamics of interactions with the mammalian plasminogen system<br>J Biomol Struct Dyn (2013) 31, 477-484. PubMed  Europe PubMed DOI
    24. 2012
  24. Caulfield,A.J. and Lathem,W.W.<br>Substrates of the plasminogen activator protease of Yersinia pestis<br>Adv Exp Med Biol (2012) 954, 253-260. PubMed  Europe PubMed DOI
  25. Eren,E. and van den Berg,B.<br>Structural basis for activation of an integral membrane protease by lipopolysaccharide<br>J Biol Chem (2012) 287, 23971-23976. PubMed  Europe PubMed DOI  S
  26. Guinet,F. and Carniel,E.<br>Impact on the host of the Yersinia pestis-specific virulence set and the contribution of the Pla surface protease<br>Adv Exp Med Biol (2012) 954, 211-216. PubMed  Europe PubMed DOI
  27. Haiko,J., Korhonen,T.K. and Laakkonen,L.<br>Plasminogen activator of Yersinia pestis<br>[ISSN:978-0-12-407744-7] (2012) 3, 289-293. DOI
    28. 2011
  28. Haiko,J., Laakkonen,L., Westerlund-Wikstrom,B. and Korhonen,T.K.<br>Molecular adaptation of a plant-bacterium outer membrane protease towards plague virulence factor Pla<br>BMC Evol Biol (2011) 11, 43-43. PubMed  Europe PubMed DOI
    29. 2010
  29. Eren,E., Murphy,M., Goguen,J. and van den Berg,B.<br>An active site water network in the plasminogen activator pla from Yersinia pestis<br>Structure (2010) 18, 809-818. PubMed  Europe PubMed DOI  S
  30. Haiko,J., Laakkonen,L., Juuti,K., Kalkkinen,N. and Korhonen,T.K.<br>The omptins of Yersinia pestis and Salmonella enterica cleave the reactive center loop of plasminogen activator inhibitor 1<br>J Bacteriol (2010) 192, 4553-4561. PubMed  Europe PubMed DOI  P
  31. Suomalainen,M., Lobo,L.A., Brandenburg,K., Lindner,B., Virkola,R., Knirel,Y.A., Anisimov,A.P., Holst,O. and Korhonen,T.K.<br>Temperature-induced changes in the lipopolysaccharide of Yersinia pestis affect plasminogen activation by the Pla surface protease<br>Infect Immun (2010) 78, 2644-2652. PubMed  Europe PubMed DOI
  32. Valls Seron,M., Haiko,J., DE Groot,P.G., Korhonen,T.K. and Meijers,J.C.<br>Thrombin-activatable fibrinolysis inhibitor is degraded by Salmonella enterica and Yersinia pestis<br>J Thromb Haemost (2010) 8, 2232-2240. PubMed  Europe PubMed DOI
    33. 2009
  33. Haiko,J., Suomalainen,M., Ojala,T., Lahteenmaki,K. and Korhonen,T.K.<br>Invited review: Breaking barriers - attack on innate immune defences by omptin surface proteases of enterobacterial pathogens<br>Innate Immun (2009) 15, 67-80. PubMed  Europe PubMed DOI
  34. Haiko,J., Kukkonen,M., Ravantti,J.J., Westerlund-Wikstrom,B. and Korhonen,T.K.<br>The single substitution I259T, conserved in the plasminogen activator Pla of pandemic Yersinia pestis branches, enhances fibrinolytic activity<br>J Bacteriol (2009) 191, 4758-4766. PubMed  Europe PubMed DOI  PMC  EPMC
    35. 2008
  35. Agarkov,A., Chauhan,S., Lory,P.J., Gilbertson,S.R. and Motin,V.L.<br>Substrate specificity and screening of the integral membrane protease Pla<br>Bioorg Med Chem Lett (2008) 18, 427-431. PubMed  Europe PubMed DOI  PMC  EPMC  P
  36. Galvan,E.M., Lasaro,M.A. and Schifferli,D.M.<br>Capsular antigen fraction 1 and Pla modulate the susceptibility of Yersinia pestis to pulmonary antimicrobial peptides such as cathelicidin<br>Infect Immun (2008) 76, 1456-1464. PubMed  Europe PubMed DOI  PMC  EPMC
  37. Zhang,S.S., Park,C.G., Zhang,P., Bartra,S.S., Plano,G.V., Klena,J.D., Skurnik,M., Hinnebusch,B.J. and Chen,T.<br>Plasminogen activator Pla of Yersinia pestis utilizes murine DEC-205 (CD205) as a receptor to promote dissemination<br>J Biol Chem (2008) 283, 31511-31521. PubMed  Europe PubMed DOI  PMC  EPMC
    38. 2007
  38. [YEAR:26-1-2007]Lathem,W.W., Price,P.A., Miller,V.L. and Goldman,W.E.<br>A plasminogen-activating protease specifically controls the development of primary pneumonic plague<br>Science (26-1-2007) 315, 509-513. PubMed  Europe PubMed DOI
  39. Suomalainen,M., Haiko,J., Ramu,P., Lobo,L., Kukkonen,M., Westerlund-Wikstrom,B., Virkola,R., Lahteenmaki,K. and Korhonen,T.K.<br>Using every trick in the book: the Pla surface protease of Yersinia pestis<br>Adv Exp Med Biol (2007) 603, 268-278. PubMed  Europe PubMed DOI  V
    40. 2006
  40. Lobo,L.A.<br>Adhesive properties of the purified plasminogen activator Pla of Yersinia pestis<br>FEMS Microbiol Lett (2006) 262, 158-162. PubMed  Europe PubMed DOI
  41. Sebbane,F., Jarrett,C.O., Gardner,D., Long,D. and Hinnebusch,B.J.<br>Role of the Yersinia pestis plasminogen activator in the incidence of distinct septicemic and bubonic forms of flea-borne plague<br>Proc Natl Acad Sci U S A (2006) 103, 5526-5530. PubMed  Europe PubMed DOI  PMC  EPMC
    42. 2004
  42. Korhonen,T.K., Lahteenmaki,K., Kukkonen,M. and Lang,H.<br>Plasminogen activator of Yersinia pestis<br>[ISSN:0-12-079610-4] (2004) 2, 217-219.  V
  43. Kukkonen,M. and Korhonen,T.K.<br>The omptin family of enterobacterial surface proteases/adhesins: from housekeeping in Escherichia coli to systemic spread of Yersinia pestis<br>Int J Med Microbiol (2004) 294, 7-14. PubMed  Europe PubMed DOI
  44. Kukkonen,M., Suomalainen,M., Kyllonen,P., Lahteenmaki,K., Lang,H., Virkola,R., Helander,I.M., Holst,O. and Korhonen,T.K.<br>Lack of O-antigen is essential for plasminogen activation by Yersinia pestis and Salmonella enterica<br>Mol Microbiol (2004) 51, 215-225. PubMed  Europe PubMed DOI
    45. 2001
  45. Kukkonen,M., Lahteenmaki,K., Suomalainen,M., Kalkkinen,N., Emody,L., Lang,H. and Korhonen,T.K.<br>Protein regions important for plasminogen activation and inactivation of alpha2-antiplasmin in the surface protease Pla of Yersinia pestis<br>Mol Microbiol (2001) 40, 1097-1111. PubMed  Europe PubMed DOI
  46. Lahteenmaki,K., Kukkonen,M. and Korhonen,T.K.<br>The Pla surface protease/adhesin of Yersinia pestis mediates bacterial invasion into human endothelial cells<br>FEBS Lett (2001) 504, 69-72. PubMed  Europe PubMed DOI
    47. 2000
  47. Cowan,C., Jones,H.A., Kaya,Y.H., Perry,R.D. and Straley,S.C.<br>Invasion of epithelial cells by Yersinia pestis: evidence for a Y. pestis-specific invasin<br>Infect Immun (2000) 68, 4523-4530. PubMed  Europe PubMed DOI  PMC  EPMC
    48. 1999
  48. Kutyrev,V., Mehigh,R.J., Motin,V.L., Pokrovskaya,M.S., Smirnov,G.B. and Brubaker,R.R.<br>Expression of the plague plasminogen activator in Yersinia pseudotuberculosis and Escherichia coli<br>Infect Immun (1999) 67, 1359-1367. PubMed  Europe PubMed  PMC  EPMC
    49. 1998
  49. Hinnebusch,B.J., Fischer,E.R. and Schwan,T.G.<br>Evaluation of the role of the Yersinia pestis plasminogen activator and other plasmid-encoded factors in temperature-dependent blockage of the flea<br>J Infect Dis (1998) 178, 1406-1415. PubMed  Europe PubMed
  50. Lahteenmaki,K., Virkola,R., Saren,A., Emody,L. and Korhonen,T.K.<br>Expression of plasminogen activator pla of Yersinia pestis enhances bacterial attachment to the mammalian extracellular matrix<br>Infect Immun (1998) 66, 5755-5762. PubMed  Europe PubMed  PMC  EPMC
    51. 1997
  51. Welkos,S.L., Friedlander,A.M. and Davis,K.J.<br>Studies on the role of plasminogen activator in systemic infection by virulent Yersinia pestis strain C092<br>Microb Pathog (1997) 23, 211-223. PubMed  Europe PubMed DOI
    52. 1995
  52. Easterbrook,T.J., Reddin,K., Robinson,A. and Modi,N.<br>Studies on the immunogenicity of the Pla protein from Yersinia pestis<br>Contrib Microbiol Immunol (1995) 13, 214-215. PubMed  Europe PubMed
    53. 1993
  53. McDonough,K.A., Barnes,A.M., Quan,T.J., Montenieri,J. and Falkow,S.<br>Mutation in the pla gene of Yersinia pestis alters the course of the plague bacillus-flea (Siphonaptera: Ceratophyllidae) interaction<br>J Med Entomol (1993) 30, 772-780. PubMed  Europe PubMed
    54. 1992
  54. [YEAR:6-11-1992]Sodeinde,O.A., Subrahmanyam,Y.V., Stark,K., Quan,T., Bao,Y. and Goguen,J.D.<br>A surface protease and the invasive character of plague<br>Science (6-11-1992) 258, 1004-1007. PubMed  Europe PubMed
    55. 1989
  55. McDonough,K.A. and Falkow,S.<br>A Yersinia pestis-specific DNA fragment encodes temperature-dependent coagulase and fibrinolysin-associated phenotypes<br>Mol Microbiol (1989) 3, 767-775. PubMed  Europe PubMed
  56. Sodeinde,O.A. and Goguen,J.D.<br>Nucleotide sequence of the plasminogen activator gene of Yersinia pestis: relationship to ompT of Escherichia coli and gene E of Salmonella typhimurium<br>Infect Immun (1989) 57, 1517-1523. PubMed  Europe PubMed  PMC  EPMC
    57. 1988
  57. Sodeinde,O.A., Sample,A.K., Brubaker,R.R. and Goguen,J.D.<br>Plasminogen activator/coagulase gene of Yersinia pestis is responsible for degradation of plasmid-encoded outer membrane proteins<br>Infect Immun (1988) 56, 2749-2752. PubMed  Europe PubMed  PMC  EPMC
  58. Sodeinde,O.A. and Goguen,J.D.<br>Genetic analysis of the 9.5-kilobase virulence plasmid of Yersinia pestis<br>Infect Immun (1988) 56, 2743-2748. PubMed  Europe PubMed  PMC  EPMC
    59. 1967
  59. Beesley,E.D., Brubaker,R.R., Janssen,W.A. and Surgalla,M.J.<br>Pesticins. 3. Expression of coagulase and mechanism of fibrinolysis<br>J Bacteriol (1967) 94, 19-26. PubMed  Europe PubMed  PMC  EPMC

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