Literature for peptidase A22.007: signal peptide peptidase-like protein 2A

(Topics flags: M Mutation, K Knockout, P Specificity, I Inhibitor, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

2024
1. Esmaeilzadeh,H., Pouladfar,G., Gholami,M.A. and Mohtadi,H.
   Mendelian Susceptibility to Mycobacterial Disease with Signal Peptide Peptidase-like 2A (SPPL2A) Deficiency: A Case Report
   Iran J Allergy Asthma Immunol23, 588-593. PubMed  Europe PubMed DOI
2023
2. Ballin,M., Griep,W., Patel,M., Karl,M., Mentrup,T., Rivera-Monroy,J., Foo,B., Schwappach,B. and Schroder,B.
   The intramembrane proteases SPPL2a and SPPL2b regulate the homeostasis of selected SNARE proteins
   FEBS J290, 2320-2337. PubMed  Europe PubMed DOI
2022
3. Travnickova,K. and Strisovsky,K.
   On the track of intramembrane clippers: the SPPL2a/b proteases caught in the act in animal models
   FEBS J PubMed  Europe PubMed DOI
2020
4. Gradtke,A.C., Mentrup,T., Lehmann,C.H.K., Cabrera-Cabrera,F., Desel,C., Okakpu,D., Assmann,M., Dalpke,A., Schaible,U.E., Dudziak,D. and Schroder,B.
   Deficiency of the Intramembrane Protease SPPL2a Alters Antimycobacterial Cytokine Responses of Dendritic Cells
   J Immunol PubMed  Europe PubMed DOI
5. Spitz,C., Schlosser,C., Guschtschin-Schmidt,N., Stelzer,W., Menig,S., Gotz,A., Haug-Kroper,M., Scharnagl,C., Langosch,D., Muhle-Goll,C. and Fluhrer,R.
   Non-canonical Shedding of TNFalpha by SPPL2a Is Determined by the Conformational Flexibility of Its Transmembrane Helix
   iScience23, 101775-101775. PubMed  Europe PubMed DOI
2019
6. Mentrup,T., Theodorou,K., Cabrera-Cabrera,F., Helbig,A.O., Happ,K., Gijbels,M., Gradtke,A.C., Rabe,B., Fukumori,A., Steiner,H., Tholey,A., Fluhrer,R., Donners,M. and Schroder,B.
   Atherogenic LOX-1 signaling is controlled by SPPL2-mediated intramembrane proteolysis
   J Exp Med216, 807-830. PubMed  Europe PubMed DOI
7. Mentrup,T. and Schroder,B.
   Intramembrane proteases protect from atherosclerosis
   Aging (Albany NY)11, 8041-8043. PubMed  Europe PubMed DOI
8. Velcicky,J., Mathison,C.J.N., Nikulin,V., Pflieger,D., Epple,R., Azimioara,M., Cow,C., Michellys,P.Y., Rigollier,P., Beisner,D.R., Bodendorf,U., Guerini,D., Liu,B., Wen,B., Zaharevitz,S. and Brandl,T.
   Discovery of orally active hydroxyethylamine based SPPL2a inhibitors
   ACS Med Chem Lett10, 887-892. PubMed  Europe PubMed DOI  I
2018
9. Kong,X.F., Martinez-Barricarte,R., Kennedy,J., Mele,F., Lazarov,T., Deenick,E.K., Ma,C.S., Breton,G., Lucero,K.B., Langlais,D., Bousfiha,A., Aytekin,C., Markle,J., Trouillet,C., Jabot-Hanin,F., Arlehamn,C.S.L., Rao,G., Picard,C., Lasseau,T., Latorre,D., Hambleton,S., Deswarte,C., Itan,Y., Abarca,K., Moraes-Vasconcelos,D., Ailal,F., Ikinciogullari,A., Dogu,F., Benhsaien,I., Sette,A., Abel,L., Boisson-Dupuis,S., Schroder,B., Nussenzweig,M.C., Liu,K., Geissmann,F., Tangye,S.G., Gros,P., Sallusto,F., Bustamante,J. and Casanova,J.L.
   Disruption of an antimycobacterial circuit between dendritic and helper T cells in human SPPL2a deficiency
   Nat Immunol19, 973-985. PubMed  Europe PubMed DOI  M
10. Velcicky,J., Bodendorf,U., Rigollier,P., Epple,R., Beisner,D.R., Guerini,D., Smith,P., Liu,B., Feifel,R., Wipfli,P., Aichholz,R., Couttet,P., Dix,I., Widmer,T., Wen,B. and Brandl,T.
    Discovery of the first potent, selective, and orally bioavailable signal peptide peptidase-like 2a (SPPL2a) inhibitor displaying pronounced immunomodulatory effects in vivo
    J Med Chem61, 865-880. PubMed  Europe PubMed DOI  I
2017
11. Mentrup,T., Fluhrer,R. and Schroder,B.
    Latest emerging functions of SPP/SPPL intramembrane proteases
    Eur J Cell Biol96, 372-382. PubMed  Europe PubMed DOI
12. Zhang,X., Gotte,M., Ibig-Rehm,Y., Schuffenhauer,A., Kamke,M., Beisner,D., Guerini,D., Siebert,D., Bonamy,G.M.C., Gabriel,D. and Bodendorf,U.
    Identification of SPPL2a inhibitors by multiparametric analysis of a high-content ultra-high-throughput screen
    SLAS Discov22, 1106-1119. PubMed  Europe PubMed DOI  I
2016
13. Fleck,D., Voss,M., Brankatschk,B., Giudici,C., Hampel,H., Schwenk,B., Edbauer,D., Fukumori,A., Steiner,H., Kremmer,E., Haug-Kroper,M., Rossner,M.J., Fluhrer,R., Willem,M. and Haass,C.
    Proteolytic processing of neuregulin 1 type III by three intramembrane-cleaving proteases
    J Biol Chem291, 318-333. PubMed  Europe PubMed DOI  P
14. Huttl,S., Helfrich,F., Mentrup,T., Held,S., Fukumori,A., Steiner,H., Saftig,P., Fluhrer,R. and Schroder,B.
    Substrate determinants of signal peptide peptidase-like 2a (SPPL2a)-mediated intramembrane proteolysis of the invariant chain CD74
    Biochem J473, 1405-1422. PubMed  Europe PubMed DOI  P
15. Schroder,B. and Saftig,P.
    Intramembrane proteolysis within lysosomes
    Ageing Res Rev32, 51-64. PubMed  Europe PubMed DOI
2015
16. Huttl,S., Klasener,K., Schweizer,M., Schneppenheim,J., Oberg,H.H., Kabelitz,D., Reth,M., Saftig,P. and Schroder,B.
    Processing of CD74 by the intramembrane protease SPPL2a is critical for B cell receptor signaling in transitional B cells
    J Immunol195, 1548-1563. PubMed  Europe PubMed DOI
2014
17. Brady,O.A., Zhou,X. and Hu,F.
    Regulated intramembrane proteolysis of the frontotemporal lobar degeneration risk factor,TMEM106B, by signal peptide peptidase-like 2a (SPPL2a)
    J Biol Chem289, 19670-19680. PubMed  Europe PubMed DOI
18. Schneppenheim,J., Huttl,S., Kruchen,A., Fluhrer,R., Muller,I., Saftig,P., Schneppenheim,R., Martin,C.L. and Schroder,B.
    Signal-peptide-peptidase-like 2a is required for CD74 intramembrane proteolysis in human B cells
    Biochem Biophys Res Commun451, 48-53. PubMed  Europe PubMed DOI  K
19. Schneppenheim,J., Huttl,S., Mentrup,T., Lullmann-Rauch,R., Rothaug,M., Engelke,M., Dittmann,K., Dressel,R., Araki,M., Araki,K., Wienands,J., Fluhrer,R., Saftig,P. and Schroder,B.
    The intramembrane proteases signal peptide peptidase-like 2a and 2b have distinct functions in vivo
    Mol Cell Biol34, 1398-1411. PubMed  Europe PubMed DOI  K
2013
20. Beisner,D.R., Langerak,P., Parker,A.E., Dahlberg,C., Otero,F.J., Sutton,S.E., Poirot,L., Barnes,W., Young,M.A., Niessen,S., Wiltshire,T., Bodendorf,U., Martoglio,B., Cravatt,B. and Cooke,M.P.
    The intramembrane protease Sppl2a is required for B cell and DC development and survival via cleavage of the invariant chain
    J Exp Med210, 23-30. PubMed  Europe PubMed DOI
21. Bergmann,H., Yabas,M., Short,A., Miosge,L., Barthel,N., Teh,C.E., Roots,C.M., Bull,K.R., Jeelall,Y., Horikawa,K., Whittle,B., Balakishnan,B., Sjollema,G., Bertram,E.M., Mackay,F., Rimmer,A.J., Cornall,R.J., Field,M.A., Andrews,T.D., Goodnow,C.C. and Enders,A.
    B cell survival, surface BCR and BAFFR expression, CD74 metabolism, and CD8- dendritic cells require the intramembrane endopeptidase SPPL2A
    J Exp Med210, 31-40. PubMed  Europe PubMed DOI
22. Bronckers,A.L., Gueneli,N., Lullmann-Rauch,R., Schneppenheim,J., Moraru,A.P., Himmerkus,N., Bervoets,T.J., Fluhrer,R., Everts,V., Saftig,P. and Schroder,B.
    The intramembrane protease SPPL2A is critical for tooth enamel formation
    J Bone Miner Res28, 1622-1630. PubMed  Europe PubMed DOI
23. Schneppenheim,J., Dressel,R., Huttl,S., Lullmann-Rauch,R., Engelke,M., Dittmann,K., Wienands,J., Eskelinen,E.L., Hermans-Borgmeyer,I., Fluhrer,R., Saftig,P. and Schroder,B.
    The intramembrane protease SPPL2a promotes B cell development and controls endosomal traffic by cleavage of the invariant chain
    J Exp Med210, 41-58. PubMed  Europe PubMed DOI
24. Voss,M., Schroder,B. and Fluhrer,R.
    Mechanism, specificity, and physiology of signal peptide peptidase (SPP) and SPP-like proteases
    Biochim Biophys Acta1828, 2828-2839. PubMed  Europe PubMed DOI
2011
25. Behnke,J., Schneppenheim,J., Koch-Nolte,F., Haag,F., Saftig,P. and Schroder,B.
    Signal-peptide-peptidase-like 2a (SPPL2a) is targeted to lysosomes/late endosomes by a tyrosine motif in its C-terminal tail
    FEBS Lett585, 2951-2957. PubMed  Europe PubMed DOI
2009
26. Golde,T.E., Wolfe,M.S. and Greenbaum,D.C.
    Signal peptide peptidases: a family of intramembrane-cleaving proteases that cleave type 2 transmembrane proteins
    Semin Cell Dev Biol20, 225-230. PubMed  Europe PubMed DOI  V
2008
27. Martin,L., Fluhrer,R., Reiss,K., Kremmer,E., Saftig,P. and Haass,C.
    Regulated intramembrane proteolysis of Bri2 (Itm2b) by ADAM10 and SPPL2a/SPPL2b
    J Biol Chem283, 1644-1652. PubMed  Europe PubMed DOI
2007
28. Kirkin,V., Cahuzac,N., Guardiola-Serrano,F., Huault,S., Luckerath,K., Friedmann,E., Novac,N., Wels,W.S., Martoglio,B., Hueber,A.O. and Zornig,M.
    The Fas ligand intracellular domain is released by ADAM10 and SPPL2a cleavage in T-cells
    Cell Death Differ14, 1678-1687. PubMed  Europe PubMed DOI
2006
29. [YEAR:9-7-2006]Friedmann,E., Hauben,E., Maylandt,K., Schleeger,S., Vreugde,S., Lichtenthaler,S.F., Kuhn,P.H., Stauffer,D., Rovelli,G. and Martoglio,B.
    SPPL2a and SPPL2b promote intramembrane proteolysis of TNFalpha in activated dendritic cells to trigger IL-12 production
    Nat Cell Biol8, 843-848. PubMed  Europe PubMed DOI
2004
30. [YEAR:21-9-2004]Friedmann,E., Lemberg,M.K., Weihofen,A., Dev,K.K., Dengler,U., Rovelli,G. and Martoglio,B.
    Consensus analysis of signal peptide peptidase and homologous human aspartic proteases reveals opposite topology of catalytic domains compared with presenilins
    J Biol Chem279, 50790-50798. PubMed  Europe PubMed DOI
2002
31. Grigorenko,A.P., Moliaka,Y.K., Korovaitseva,G.I. and Rogaev,E.I.
    Novel class of polytopic proteins with domains associated with putative protease activity
    Biochemistry (Mosc)67, 826-835. PubMed  Europe PubMed DOI