Literature for peptidase A22.007: signal peptide peptidase-like protein 2A

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

(Topics flags: M Mutation, K Knockout, P Specificity, I Inhibitor, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

2024

Esmaeilzadeh,H., Pouladfar,G., Gholami,M.A. and Mohtadi,H. Mendelian Susceptibility to Mycobacterial Disease with Signal Peptide Peptidase-like 2A (SPPL2A) Deficiency: A Case Report Iran J Allergy Asthma Immunol (2024) 23, 588-593. PubMed Europe PubMed DOI

2023

Ballin,M., Griep,W., Patel,M., Karl,M., Mentrup,T., Rivera-Monroy,J., Foo,B., Schwappach,B. and Schroder,B. The intramembrane proteases SPPL2a and SPPL2b regulate the homeostasis of selected SNARE proteins FEBS J (2023) 290, 2320-2337. PubMed Europe PubMed DOI

2022

Travnickova,K. and Strisovsky,K. On the track of intramembrane clippers: the SPPL2a/b proteases caught in the act in animal models FEBS J (2022) PubMed Europe PubMed DOI

2020

Gradtke,A.C., Mentrup,T., Lehmann,C.H.K., Cabrera-Cabrera,F., Desel,C., Okakpu,D., Assmann,M., Dalpke,A., Schaible,U.E., Dudziak,D. and Schroder,B. Deficiency of the Intramembrane Protease SPPL2a Alters Antimycobacterial Cytokine Responses of Dendritic Cells J Immunol (2020) PubMed Europe PubMed DOI
Spitz,C., Schlosser,C., Guschtschin-Schmidt,N., Stelzer,W., Menig,S., Gotz,A., Haug-Kroper,M., Scharnagl,C., Langosch,D., Muhle-Goll,C. and Fluhrer,R. Non-canonical Shedding of TNFalpha by SPPL2a Is Determined by the Conformational Flexibility of Its Transmembrane Helix iScience (2020) 23, 101775-101775. PubMed Europe PubMed DOI PMC EPMC

2019

Mentrup,T., Theodorou,K., Cabrera-Cabrera,F., Helbig,A.O., Happ,K., Gijbels,M., Gradtke,A.C., Rabe,B., Fukumori,A., Steiner,H., Tholey,A., Fluhrer,R., Donners,M. and Schroder,B. Atherogenic LOX-1 signaling is controlled by SPPL2-mediated intramembrane proteolysis J Exp Med (2019) 216, 807-830. PubMed Europe PubMed DOI
Mentrup,T. and Schroder,B. Intramembrane proteases protect from atherosclerosis Aging (Albany NY) (2019) 11, 8041-8043. PubMed Europe PubMed DOI
Velcicky,J., Mathison,C.J.N., Nikulin,V., Pflieger,D., Epple,R., Azimioara,M., Cow,C., Michellys,P.Y., Rigollier,P., Beisner,D.R., Bodendorf,U., Guerini,D., Liu,B., Wen,B., Zaharevitz,S. and Brandl,T. Discovery of orally active hydroxyethylamine based SPPL2a inhibitors ACS Med Chem Lett (2019) 10, 887-892. PubMed Europe PubMed DOI PMC EPMC I

2018

Kong,X.F., Martinez-Barricarte,R., Kennedy,J., Mele,F., Lazarov,T., Deenick,E.K., Ma,C.S., Breton,G., Lucero,K.B., Langlais,D., Bousfiha,A., Aytekin,C., Markle,J., Trouillet,C., Jabot-Hanin,F., Arlehamn,C.S.L., Rao,G., Picard,C., Lasseau,T., Latorre,D., Hambleton,S., Deswarte,C., Itan,Y., Abarca,K., Moraes-Vasconcelos,D., Ailal,F., Ikinciogullari,A., Dogu,F., Benhsaien,I., Sette,A., Abel,L., Boisson-Dupuis,S., Schroder,B., Nussenzweig,M.C., Liu,K., Geissmann,F., Tangye,S.G., Gros,P., Sallusto,F., Bustamante,J. and Casanova,J.L. Disruption of an antimycobacterial circuit between dendritic and helper T cells in human SPPL2a deficiency Nat Immunol (2018) 19, 973-985. PubMed Europe PubMed DOI M
Velcicky,J., Bodendorf,U., Rigollier,P., Epple,R., Beisner,D.R., Guerini,D., Smith,P., Liu,B., Feifel,R., Wipfli,P., Aichholz,R., Couttet,P., Dix,I., Widmer,T., Wen,B. and Brandl,T. Discovery of the first potent, selective, and orally bioavailable signal peptide peptidase-like 2a (SPPL2a) inhibitor displaying pronounced immunomodulatory effects in vivo J Med Chem (2018) 61, 865-880. PubMed Europe PubMed DOI I

2017

Mentrup,T., Fluhrer,R. and Schroder,B. Latest emerging functions of SPP/SPPL intramembrane proteases Eur J Cell Biol (2017) 96, 372-382. PubMed Europe PubMed DOI
Zhang,X., Gotte,M., Ibig-Rehm,Y., Schuffenhauer,A., Kamke,M., Beisner,D., Guerini,D., Siebert,D., Bonamy,G.M.C., Gabriel,D. and Bodendorf,U. Identification of SPPL2a inhibitors by multiparametric analysis of a high-content ultra-high-throughput screen SLAS Discov (2017) 22, 1106-1119. PubMed Europe PubMed DOI I

2016

Fleck,D., Voss,M., Brankatschk,B., Giudici,C., Hampel,H., Schwenk,B., Edbauer,D., Fukumori,A., Steiner,H., Kremmer,E., Haug-Kroper,M., Rossner,M.J., Fluhrer,R., Willem,M. and Haass,C. Proteolytic processing of neuregulin 1 type III by three intramembrane-cleaving proteases J Biol Chem (2016) 291, 318-333. PubMed Europe PubMed DOI P
Huttl,S., Helfrich,F., Mentrup,T., Held,S., Fukumori,A., Steiner,H., Saftig,P., Fluhrer,R. and Schroder,B. Substrate determinants of signal peptide peptidase-like 2a (SPPL2a)-mediated intramembrane proteolysis of the invariant chain CD74 Biochem J (2016) 473, 1405-1422. PubMed Europe PubMed DOI P
Schroder,B. and Saftig,P. Intramembrane proteolysis within lysosomes Ageing Res Rev (2016) 32, 51-64. PubMed Europe PubMed DOI

2015

Huttl,S., Klasener,K., Schweizer,M., Schneppenheim,J., Oberg,H.H., Kabelitz,D., Reth,M., Saftig,P. and Schroder,B. Processing of CD74 by the intramembrane protease SPPL2a is critical for B cell receptor signaling in transitional B cells J Immunol (2015) 195, 1548-1563. PubMed Europe PubMed DOI

2014

Brady,O.A., Zhou,X. and Hu,F. Regulated intramembrane proteolysis of the frontotemporal lobar degeneration risk factor,TMEM106B, by signal peptide peptidase-like 2a (SPPL2a) J Biol Chem (2014) 289, 19670-19680. PubMed Europe PubMed DOI
Schneppenheim,J., Huttl,S., Kruchen,A., Fluhrer,R., Muller,I., Saftig,P., Schneppenheim,R., Martin,C.L. and Schroder,B. Signal-peptide-peptidase-like 2a is required for CD74 intramembrane proteolysis in human B cells Biochem Biophys Res Commun (2014) 451, 48-53. PubMed Europe PubMed DOI K
Schneppenheim,J., Huttl,S., Mentrup,T., Lullmann-Rauch,R., Rothaug,M., Engelke,M., Dittmann,K., Dressel,R., Araki,M., Araki,K., Wienands,J., Fluhrer,R., Saftig,P. and Schroder,B. The intramembrane proteases signal peptide peptidase-like 2a and 2b have distinct functions in vivo Mol Cell Biol (2014) 34, 1398-1411. PubMed Europe PubMed DOI K

2013

Beisner,D.R., Langerak,P., Parker,A.E., Dahlberg,C., Otero,F.J., Sutton,S.E., Poirot,L., Barnes,W., Young,M.A., Niessen,S., Wiltshire,T., Bodendorf,U., Martoglio,B., Cravatt,B. and Cooke,M.P. The intramembrane protease Sppl2a is required for B cell and DC development and survival via cleavage of the invariant chain J Exp Med (2013) 210, 23-30. PubMed Europe PubMed DOI
Bergmann,H., Yabas,M., Short,A., Miosge,L., Barthel,N., Teh,C.E., Roots,C.M., Bull,K.R., Jeelall,Y., Horikawa,K., Whittle,B., Balakishnan,B., Sjollema,G., Bertram,E.M., Mackay,F., Rimmer,A.J., Cornall,R.J., Field,M.A., Andrews,T.D., Goodnow,C.C. and Enders,A. B cell survival, surface BCR and BAFFR expression, CD74 metabolism, and CD8- dendritic cells require the intramembrane endopeptidase SPPL2A J Exp Med (2013) 210, 31-40. PubMed Europe PubMed DOI
Bronckers,A.L., Gueneli,N., Lullmann-Rauch,R., Schneppenheim,J., Moraru,A.P., Himmerkus,N., Bervoets,T.J., Fluhrer,R., Everts,V., Saftig,P. and Schroder,B. The intramembrane protease SPPL2A is critical for tooth enamel formation J Bone Miner Res (2013) 28, 1622-1630. PubMed Europe PubMed DOI
Schneppenheim,J., Dressel,R., Huttl,S., Lullmann-Rauch,R., Engelke,M., Dittmann,K., Wienands,J., Eskelinen,E.L., Hermans-Borgmeyer,I., Fluhrer,R., Saftig,P. and Schroder,B. The intramembrane protease SPPL2a promotes B cell development and controls endosomal traffic by cleavage of the invariant chain J Exp Med (2013) 210, 41-58. PubMed Europe PubMed DOI
Voss,M., Schroder,B. and Fluhrer,R. Mechanism, specificity, and physiology of signal peptide peptidase (SPP) and SPP-like proteases Biochim Biophys Acta (2013) 1828, 2828-2839. PubMed Europe PubMed DOI

2011

Behnke,J., Schneppenheim,J., Koch-Nolte,F., Haag,F., Saftig,P. and Schroder,B. Signal-peptide-peptidase-like 2a (SPPL2a) is targeted to lysosomes/late endosomes by a tyrosine motif in its C-terminal tail FEBS Lett (2011) 585, 2951-2957. PubMed Europe PubMed DOI

2009

Golde,T.E., Wolfe,M.S. and Greenbaum,D.C. Signal peptide peptidases: a family of intramembrane-cleaving proteases that cleave type 2 transmembrane proteins Semin Cell Dev Biol (2009) 20, 225-230. PubMed Europe PubMed DOI V

2008

Martin,L., Fluhrer,R., Reiss,K., Kremmer,E., Saftig,P. and Haass,C. Regulated intramembrane proteolysis of Bri2 (Itm2b) by ADAM10 and SPPL2a/SPPL2b J Biol Chem (2008) 283, 1644-1652. PubMed Europe PubMed DOI

2007

Kirkin,V., Cahuzac,N., Guardiola-Serrano,F., Huault,S., Luckerath,K., Friedmann,E., Novac,N., Wels,W.S., Martoglio,B., Hueber,A.O. and Zornig,M. The Fas ligand intracellular domain is released by ADAM10 and SPPL2a cleavage in T-cells Cell Death Differ (2007) 14, 1678-1687. PubMed Europe PubMed DOI

2006

[YEAR:9-7-2006]Friedmann,E., Hauben,E., Maylandt,K., Schleeger,S., Vreugde,S., Lichtenthaler,S.F., Kuhn,P.H., Stauffer,D., Rovelli,G. and Martoglio,B. SPPL2a and SPPL2b promote intramembrane proteolysis of TNFalpha in activated dendritic cells to trigger IL-12 production Nat Cell Biol (9-7-2006) 8, 843-848. PubMed Europe PubMed DOI

2004

[YEAR:21-9-2004]Friedmann,E., Lemberg,M.K., Weihofen,A., Dev,K.K., Dengler,U., Rovelli,G. and Martoglio,B. Consensus analysis of signal peptide peptidase and homologous human aspartic proteases reveals opposite topology of catalytic domains compared with presenilins J Biol Chem (21-9-2004) 279, 50790-50798. PubMed Europe PubMed DOI

2002

Grigorenko,A.P., Moliaka,Y.K., Korovaitseva,G.I. and Rogaev,E.I. Novel class of polytopic proteins with domains associated with putative protease activity Biochemistry (Mosc) (2002) 67, 826-835. PubMed Europe PubMed DOI