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Literature for peptidase A22.002: presenilin 2

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Literature Pharma

(Topics flags: T Target, M Mutation, R Splicing, P Specificity, I Inhibitor, K Knockout, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Fremlen,H. and Burmann,B.M.
    Maintaining the Integral Membrane Proteome: Revisiting the Functional Repertoire of Integral Membrane Proteases
    Chembiocheme202500048-e202500048. PubMed  Europe PubMed DOI  V
  2. Liu,H., Marsh,T.W., Shi,X., Renton,A.E., Bowling,K.M., Ziegemeier,E., Wang,G., Cao,Y., Aristel,A., Li,J., Dickson,A., Perrin,R.J., Goate,A.M., Fernandez,V., Day,G.S., Doering,M., Daniels,A., Gordon,B.A., Benzinger,T.L.S., Hassenstab,J., Ibanez,L., Supnet-Bell,C., Xiong,C., Allegri,R., Berman,S.B., Fox,N.C., Ryan,N., Huey,E.D., Voglein,J., Noble,J.M., Roh,J.H., Jucker,M., Laske,C., Ikeuchi,T., Sanchez-Valle,R., Schofield,P.R., Chrem Mendez,P., Chhatwal,J.P., Farlow,M., Lee,J.H., Levey,A.I., Levin,J., Lopera,F., Martins,R., Niimi,Y., Rosa-Neto,P., Morris,J.C., Bateman,R.J., Karch,C.M., Cruchaga,C., McDade,E. and Llibre-Guerra,J.J.
    The landscape of autosomal-dominant Alzheimer's disease: global distribution and age of onset
    Brain PubMed  Europe PubMed DOI
  3. Nadendla,S. and Mohiuddin,S.S.
    Biochemistry, Presenilin
     PubMed  Europe PubMed
    4. 2024
  4. Colijn,M.A. and Ismail,Z.
    Presenilin Gene Mutation-associated Psychosis: Phenotypic Characteristics and Clinical Implications
    Alzheimer Dis Assoc Disord38, 101-106. PubMed  Europe PubMed DOI  V
  5. Gao,C., Shang,J., Sun,Z., Xia,M., Gao,D., Sun,R., Li,W., Wang,F. and Zhang,J.
    Presenilin2 D439A Mutation Induces Dysfunction of Mitochondrial Fusion/Fission Dynamics and Abnormal Regulation of GTPase Activity
    Mol Neurobiol61, 5047-5070. PubMed  Europe PubMed DOI  K
    6. 2023
  6. Makarov,M., Kushnireva,L., Papa,M. and Korkotian,E.
    Presenilins and mitochondria-an intriguing link: mini-review
    Front Neurosci17, 1249815-1249815. PubMed  Europe PubMed DOI  V
    7. 2020
  7. Barman,N.C., Khan,N.M., Islam,M., Nain,Z., Roy,R.K., Haque,A. and Barman,S.K.
    CRISPR-Cas9: A Promising Genome Editing Therapeutic Tool for Alzheimer's Disease-A Narrative Review
    Neurol Ther9, 419-434. PubMed  Europe PubMed DOI  V
  8. Cai,T. and Tomita,T.
    Structure-activity relationship of presenilin in gamma-secretase-mediated intramembrane cleavage
    Semin Cell Dev Biol PubMed  Europe PubMed DOI
  9. Contino,S., Suelves,N., Vrancx,C., Vadukul,D.M., Payen,V.L., Stanga,S., Bertrand,L. and Kienlen-Campard,P.
    Presenilin-Deficient Neurons and Astrocytes Display Normal Mitochondrial Phenotypes
    Front Neurosci14, 586108-586108. PubMed  Europe PubMed DOI  K
  10. Dehury,B. and Kepp,K.P.
    Membrane dynamics of gamma-secretase with the anterior pharynx-defective 1B subunit
    J Cell Biochem PubMed  Europe PubMed DOI
  11. Escamilla-Ayala,A., Wouters,R., Sannerud,R. and Annaert,W.
    Contribution of the presenilins in the cell biology, structure and function of gamma-secretase
    Semin Cell Dev Biol PubMed  Europe PubMed DOI
  12. Hin,N., Newman,M., Kaslin,J., Douek,A.M., Lumsden,A., Nik,S.H.M., Dong,Y., Zhou,X.F., Manucat-Tan,N.B., Ludington,A., Adelson,D.L., Pederson,S. and Lardelli,M.
    Accelerated brain aging towards transcriptional inversion in a zebrafish model of the K115fs mutation of human PSEN2
    PLoS ONE15, e0227258-e0227258. PubMed  Europe PubMed DOI  M
  13. Jiang,H., Pederson,S.M., Newman,M., Dong,Y., Barthelson,K. and Lardelli,M.
    Transcriptome analysis indicates dominant effects on ribosome and mitochondrial function of a premature termination codon mutation in the zebrafish gene psen2
    PLoS ONE15, e0232559-e0232559. PubMed  Europe PubMed DOI
  14. Kabir,M.T., Uddin,M.S., Setu,J.R., Ashraf,G.M., Bin-Jumah,M.N. and Abdel-Daim,M.M.
    Exploring the Role of PSEN Mutations in the Pathogenesis of Alzheimer's Disease
    Neurotox Res PubMed  Europe PubMed DOI
  15. Mehra,R. and Kepp,K.P.
    Identification of structural calcium binding sites in membrane-bound presenilin 1 and 2
    J Phys Chem B PubMed  Europe PubMed DOI
  16. Pimenova,A.A. and Goate,A.M.
    Novel presenilin 1 and 2 double knock-out cell line for in vitro validation of PSEN1 and PSEN2 mutations
    Neurobiol Dis138, 104785-104785. PubMed  Europe PubMed DOI  K
  17. Wong,T.H., Seelaar,H., Melhem,S., Rozemuller,A.J.M. and van Swieten,J.C.
    Genetic screening in early-onset Alzheimer's disease identified three novel presenilin mutations
    Neurobiol Aging86, e9-e201. PubMed  Europe PubMed DOI  M
    18. 2019
  18. Aathi,M. and Piramanayagam,S.
    From EST to structure models for functional inference of APP, BACE1, PSEN1, PSEN2 genes
    Bioinformation15, 760-771. PubMed  Europe PubMed DOI  I
  19. Braggin,J.E., Bucks,S.A., Course,M.M., Smith,C.L., Sopher,B., Osnis,L., Shuey,K.D., Domoto-Reilly,K., Caso,C., Kinoshita,C., Scherpelz,K.P., Cross,C., Grabowski,T., Nik,S.H.M., Newman,M., Garden,G.A., Leverenz,J.B., Tsuang,D., Latimer,C., Gonzalez-Cuyar,L.F., Keene,C.D., Morrison,R.S., Rhoads,K., Wijsman,E.M., Dorschner,M.O., Lardelli,M., Young,J.E., Valdmanis,P.N., Bird,T.D. and Jayadev,S.
    Alternative splicing in a presenilin 2 variant associated with Alzheimer disease
    Ann Clin Transl Neurol6, 762-777. PubMed  Europe PubMed DOI  M
  20. Dehury,B., Tang,N. and Kepp,K.P.
    Insights into membrane-bound presenilin 2 from all-atom molecular dynamics simulations
    J Biomol Struct Dyn1-27. PubMed  Europe PubMed DOI
  21. Fedeli,C., Filadi,R., Rossi,A., Mammucari,C. and Pizzo,P.
    PSEN2 (presenilin 2) mutants linked to familial Alzheimer disease impair autophagy by altering Ca(2+) homeostasis
    Autophagy15, 2044-2062. PubMed  Europe PubMed DOI  M
  22. Gao,Y., Ren,R.J., Zhong,Z.L., Dammer,E., Zhao,Q.H., Shan,S., Zhou,Z., Li,X., Zhang,Y.Q., Cui,H.L., Hu,Y.B., Chen,S.D., Chen,J.J., Guo,Q.H. and Wang,G.
    Mutation profile of APP, PSEN1, and PSEN2 in Chinese familial Alzheimer's disease
    Neurobiol Aging77, 154-157. PubMed  Europe PubMed DOI  M
  23. Giau,V.V., Bagyinszky,E., Yang,Y.S., Youn,Y.C., An,S.S.A. and Kim,S.Y.
    Genetic analyses of early-onset Alzheimer's disease using next generation sequencing
    Sci Rep9, 8368-8368. PubMed  Europe PubMed DOI  M
  24. Oikawa,N. and Walter,J.
    Presenilins and gamma-secretase in membrane proteostasis
    Cells8, PubMed  Europe PubMed DOI
  25. Wells,J.L. and Pasternak,S.H.
    Case report of a 63-year-old patient with Alzheimer disease and a novel presenilin 2 mutation
    Alzheimer Dis Assoc Disord33, 166-169. PubMed  Europe PubMed DOI  M
    26. 2018
  26. Dhaliwal,J., Kannangara,T.S., Vaculik,M., Xue,Y., Kumar,K.L., Maione,A., Beique,J.C., Shen,J. and Lagace,D.C.
    Adult hippocampal neurogenesis occurs in the absence of presenilin 1 and presenilin 2
    Sci Rep8, 17931-17931. PubMed  Europe PubMed DOI  K
  27. Giau,V.V., Pyun,J.M., Bagyinszky,E., An,S.S.A. and Kim,S.
    A pathogenic PSEN2 p.His169Asn mutation associated with early-onset Alzheimer's disease
    Clin Interv Aging13, 1321-1329. PubMed  Europe PubMed DOI  M
  28. Hsu,S., Gordon,B.A., Hornbeck,R., Norton,J.B., Levitch,D., Louden,A., Ziegemeier,E., Laforce R Jr, Chhatwal,J., Day,G.S., McDade,E., Morris,J.C., Fagan,A.M., Benzinger,T.L.S., Goate,A.M., Cruchaga,C., Bateman,R.J. and Karch,C.M.
    Discovery and validation of autosomal dominant Alzheimer's disease mutations
    Alzheimers Res Ther10, 67-67. PubMed  Europe PubMed DOI  M
  29. Jiang,H., Jayadev,S., Lardelli,M. and Newman,M.
    A review of the familial Alzheimer's disease locus PRESENILIN 2 and its relationship to PRESENILIN 1
    J Alzheimers Dis66, 1323-1339. PubMed  Europe PubMed DOI
  30. Jiang,H., Newman,M. and Lardelli,M.
    The zebrafish orthologue of familial Alzheimer's disease gene PRESENILIN 2 is required for normal adult melanotic skin pigmentation
    PLoS ONE13, e0206155-e0206155. PubMed  Europe PubMed DOI
  31. Ma,L., Zhang,J., Shi,Y., Wang,W., Ren,Z., Xia,M., Zhang,Y. and Yang,M.
    Gene mutations in a Han Chinese Alzheimer's disease cohort
    Brain Behave01180-e01180. PubMed  Europe PubMed DOI  M
  32. Shi,T.W., Bai,N., Zhang,J.A., Lu,F., Chen,X.B., Kong,X.D. and Yu,J.B.
    Mutations in the gamma-secretase genes PSEN1, PSENEN, and NCSTN in a family with acne inversa
    Eur J Dermatol28, 374-376. PubMed  Europe PubMed DOI  M
  33. Stanga,S., Vrancx,C., Tasiaux,B., Marinangeli,C., Karlstrom,H. and Kienlen-Campard,P.
    Specificity of presenilin-1- and presenilin-2-dependent gamma-secretases towards substrate processing
    J Cell Mol Med22, 823-833. PubMed  Europe PubMed DOI  I
  34. Yang,G., Yu,K., Kubicek,J. and Labahn,J.
    Data on solubilization, identification, and thermal stability of human presenilin-2
    Data Brief17, 626-630. PubMed  Europe PubMed DOI
    35. 2017
  35. Grigorenko,A.P., Moliaka,Y.K., Plotnikova,O.V., Smirnov,A., Nikishina,V.A., Goltsov,A.Y., Gusev,F., Andreeva,T.V., Nelson,O., Bezprozvanny,I. and Rogaev,E.I.
    Mutational re-modeling of di-aspartyl intramembrane proteases: uncoupling physiologically-relevant activities from those associated with Alzheimer's disease
    Oncotarget8, 82006-82026. PubMed  Europe PubMed DOI  M
  36. Lanoiselee,H.M., Nicolas,G., Wallon,D., Rovelet-Lecrux,A., Lacour,M., Rousseau,S., Richard,A.C., Pasquier,F., Rollin-Sillaire,A., Martinaud,O., Quillard-Muraine,M., de la Sayette,V., Boutoleau-Bretonniere,C., Etcharry-Bouyx,F., Chauvire,V., Sarazin,M., le Ber,I., Epelbaum,S., Jonveaux,T., Rouaud,O., Ceccaldi,M., Felician,O., Godefroy,O., Formaglio,M., Croisile,B., Auriacombe,S., Chamard,L., Vincent,J.L., Sauvee,M., Marelli-Tosi,C., Gabelle,A., Ozsancak,C., Pariente,J., Paquet,C., Hannequin,D. and Campion,D.
    APP, PSEN1, and PSEN2 mutations in early-onset Alzheimer disease: A genetic screening study of familial and sporadic cases
    PLoS Med14, e1002270-e1002270. PubMed  Europe PubMed DOI  M
  37. Li,L.H., Tu,Q.Y., Deng,X.H., Xia,J., Hou,D.R., Guo,K. and Zi,X.H.
    Mutant presenilin2 promotes apoptosis through the p53/miR-34a axis in neuronal cells
    Brain Res1662, 57-64. PubMed  Europe PubMed DOI  M
  38. Ortiz-Virumbrales,M., Moreno,C.L., Kruglikov,I., Marazuela,P., Sproul,A., Jacob,S., Zimmer,M., Paull,D., Zhang,B., Schadt,E.E., Ehrlich,M.E., Tanzi,R.E., Arancio,O., Noggle,S. and Gandy,S.
    CRISPR/Cas9-Correctable mutation-related molecular and physiological phenotypes in iPSC-derived Alzheimer's PSEN2 N141I neurons
    Acta Neuropathol Commun5, 77-77. PubMed  Europe PubMed DOI  M
  39. Park,K.W., An,S.S., Bagyinszky,E. and Kim,S.
    A case of possibly pathogenic PSEN2 R62C mutation in a patient with probable early-onset Alzheimer's dementia supported by structure prediction
    Clin Interv Aging12, 367-375. PubMed  Europe PubMed DOI  M
  40. Zhou,R., Yang,G. and Shi,Y.
    Dominant negative effect of the loss-of-function gamma-secretase mutants on the wild-type enzyme through heterooligomerization
    Proc Natl Acad Sci U S A114, 12731-12736. PubMed  Europe PubMed DOI  M
    41. 2016
  41. Agrawal,V., Sawhney,N., Hickey,E. and McCarthy,J.V.
    Loss of presenilin 2 function is associated with defective LPS-mediated innate immune responsiveness
    Mol Neurobiol53, 3428-3438. PubMed  Europe PubMed DOI
  42. Ebrahimie,E., Moussavi Nik,S.H., Newman,M., Van Der Hoek,M. and Lardelli,M.
    The zebrafish equivalent of Alzheimer's disease-associated PRESENILIN isoform PS2V regulates inflammatory and other responses to hypoxic stress
    J Alzheimers Dis52, 581-608. PubMed  Europe PubMed DOI  M
  43. Fukumori,A. and Steiner,H.
    Substrate recruitment of gamma-secretase and mechanism of clinical presenilin mutations revealed by photoaffinity mapping
    EMBO J35, 1628-1643. PubMed  Europe PubMed DOI
  44. Marin-Munoz,J., Noguera-Perea,M.F., Gomez-Tortosa,E., Lopez-Motos,D., Antequera-Torres,M., Martinez-Herrada,B., Manzanares-Sanchez,S., Vivancos-Moreau,L., Legaz-Garcia,A., Rabano-Gutierrez Del Arroyo,A. and Antunez-Almagro,C.
    Novel mutation (Gly212Val) in the PS2 gene associated with early-onset familial Alzheimer's disease
    J Alzheimers Dis53, 73-78. PubMed  Europe PubMed DOI  M
  45. Meckler,X. and Checler,F.
    Presenilin 1 and presenilin 2 target gamma-secretase complexes to distinct cellular compartments
    J Biol Chem291, 12821-12837. PubMed  Europe PubMed DOI
  46. Sannerud,R., Esselens,C., Ejsmont,P., Mattera,R., Rochin,L., Tharkeshwar,A.K., De Baets,G., De Wever,V., Habets,R., Baert,V., Vermeire,W., Michiels,C., Groot,A.J., Wouters,R., Dillen,K., Vints,K., Baatsen,P., Munck,S., Derua,R., Waelkens,E., Basi,G.S., Mercken,M., Vooijs,M., Bollen,M., Schymkowitz,J., Rousseau,F., Bonifacino,J.S., Van Niel,G., De Strooper,B. and Annaert,W.
    Restricted Location of PSEN2/gamma-Secretase Determines Substrate Specificity and Generates an Intracellular Abeta Pool
    Cell166, 193-208. PubMed  Europe PubMed DOI
    47. 2015
  47. Cai,Y., An,S.S. and Kim,S.
    Mutations in presenilin 2 and its implications in Alzheimer's disease and other dementia-associated disorders
    Clin Interv Aging10, 1163-1172. PubMed  Europe PubMed DOI  M
  48. Walter,J.
    Twenty years of presenilins-important proteins in health and disease
    Mol Med21 Suppl 1, S41-S48. PubMed  Europe PubMed DOI  V
  49. Xia,M., Chen,S., Shi,Y., Huang,Y., Xu,J., Zhao,T., He,S., Wu,Y., Xu,C., Zang,W. and Zhang,J.
    Probable novel PSEN2 Pro123Leu mutation in a Chinese Han family of Alzheimer's disease
    Neurobiol Aging36, 3334.e13-3334.e18. PubMed  Europe PubMed DOI  M
    50. 2014
  50. Acx,H., Chavez-Gutierrez,L., Serneels,L., Lismont,S., Benurwar,M., Elad,N. and De Strooper,B.
    Signature amyloid beta profiles are produced by different gamma-secretase complexes
    J Biol Chem289, 4346-4355. PubMed  Europe PubMed DOI
  51. Gai,J.W., Wahafu,W., Hsieh,Y.C., Liu,M., Zhang,L., Li,S.W., Zhang,B., He,Q., Guo,H. and Jin,J.
    Inhibition of presenilins attenuates proliferation and invasion in bladder cancer cells through multiple pathways
    Urol Oncol32, 36-25. PubMed  Europe PubMed DOI  I
  52. Niu,F., Yu,S., Zhang,Z., Yi,X., Ye,L., Tang,W., Qiu,C., Wen,H., Sun,Y., Gao,J. and Guo,Y.
    Novel mutation in the PSEN2 gene (N141Y) associated with early-onset autosomal dominant Alzheimer's disease in a Chinese Han family
    Neurobiol Aging35, 2420-2425. PubMed  Europe PubMed DOI  M
  53. Youn,Y.C., Bagyinszky,E., Kim,H., Choi,B.O., An,S.S. and Kim,S.
    Probable novel PSEN2 Val214Leu mutation in Alzheimer's disease supported by structural prediction
    BMC Neurol14, 105-105. PubMed  Europe PubMed DOI  M
    54. 2013
  54. Jeon,A.H., Bohm,C., Chen,F., Huo,H., Ruan,X., Ren,C.H., Ho,K., Qamar,S., Mathews,P.M., Fraser,P.E., Mount,H.T., St George-Hyslop,P. and Schmitt-Ulms,G.
    Interactome analyses of mature gamma-secretase complexes reveal distinct molecular environments of presenilin (PS) paralogs and preferential binding of signal peptide peptidase to PS2
    J Biol Chem288, 15352-15366. PubMed  Europe PubMed DOI
  55. Piao,Y., Kimura,A., Urano,S., Saito,Y., Taru,H., Yamamoto,T., Hata,S. and Suzuki,T.
    Mechanism of intramembrane cleavage of alcadeins by gamma-secretase
    PLoS ONE8, e62431-e62431. PubMed  Europe PubMed DOI  P
  56. Smolarkiewicz,M., Skrzypczak,T. and Wojtaszek,P.
    The very many faces of presenilins and the gamma-secretase complex
    Protoplasma250, 997-1011. PubMed  Europe PubMed DOI  V
  57. Wilson,L. and Lardelli,M.
    The development of an in vivo gamma-secretase assay using zebrafish embryos
    J Alzheimers Dis36, 521-534. PubMed  Europe PubMed DOI
  58. Zhang,S., Zhang,M., Cai,F. and Song,W.
    Biological function of presenilin and its role in AD pathogenesis
    Transl Neurodegener2, 15-15. PubMed  Europe PubMed DOI
    59. 2012
  59. De Strooper,B., Iwatsubo,T. and Wolfe,M.S.
    Presenilins and gamma-secretase: structure, function, and role in Alzheimer disease
    Cold Spring Harb Perspect Med2, a006304-a006304. PubMed  Europe PubMed DOI
  60. Park,M.H., Choi,D.Y., Jin,H.W., Yoo,H.S., Han,J.Y., Oh,K.W., Han,S.B., Hwang,D.Y. and Hong,J.T.
    Mutant presenilin 2 increases beta-secretase activity through reactive oxygen species-dependent activation of extracellular signal-regulated kinase
    J Neuropathol Exp Neurol71, 130-139. PubMed  Europe PubMed DOI  M
  61. St George-Hyslop,P. and Fraser,P.E.
    Assembly of the presenilin gamma-/epsilon-secretase complex
    J Neurochem120 Suppl 1, 84-88. PubMed  Europe PubMed DOI
  62. Testi,S., Fabrizi,G.M., Pompanin,S. and Cagnin,A.
    Autosomal Dominant Alzheimer's Disease with Early Frontal Lobe Involvement Associated with the Met239Ile Mutation of Presenilin 2 Gene
    J Alzheimers Dis31, 7-11. PubMed  Europe PubMed DOI  M
  63. Wolfe,M.S.
    Presenilin 2
    [ISSN:978-0-12-407744-7]3, 278-281. DOI
    64. 2011
  64. Barthet,G., Shioi,J., Shao,Z., Ren,Y., Georgakopoulos,A. and Robakis,N.K.
    Inhibitors of gamma-secretase stabilize the complex and differentially affect processing of amyloid precursor protein and other substrates
    FASEB J25, 2937-2946. PubMed  Europe PubMed DOI  I
  65. Franberg,J., Svensson,A.I., Winblad,B., Karlstrom,H. and Frykman,S.
    Minor contribution of presenilin 2 for gamma-secretase activity in mouse embryonic fibroblasts and adult mouse brain
    Biochem Biophys Res Commun404, 564-568. PubMed  Europe PubMed DOI
  66. Han,W., Ji,T., Wang,L., Yan,L., Wang,H., Luo,Z., Mei,B. and Su,J.
    Abnormalities in periodontal and salivary tissues in conditional presenilin 1 and presenilin 2 double knockout mice
    Mol Cell Biochem347, 13-20. PubMed  Europe PubMed DOI  K
  67. Ho,A. and Shen,J.
    Presenilins in synaptic function and disease
    Trends Mol Med17, 617-624. PubMed  Europe PubMed DOI  V
  68. Neely,K.M. and Green,K.N.
    Presenilins mediate efficient proteolysis via the autophagosome-lysosome system
    Autophagy7, 664-665. PubMed  Europe PubMed DOI
  69. Piscopo,P., Talarico,G., Malvezzi-Campeggi,L., Crestini,A., Rivabene,R., Gasparini,M., Tosto,G., Vanacore,N., Lenzi,G.L., Bruno,G. and Confaloni,A.
    Presenilin 2 mutation R71W in an Italian early-onset sporadic Alzheimer's disease case
    J Neurol258, 2043-2047. PubMed  Europe PubMed DOI  M
  70. Toda,T., Noda,Y., Ito,G., Maeda,M. and Shimizu,T.
    Presenilin-2 mutation causes early amyloid accumulation and memory impairment in a transgenic mouse model of Alzheimer's disease
    J Biomed Biotechnol2011, 617974-617974. PubMed  Europe PubMed DOI  M
  71. Yonemura,Y., Futai,E., Yagishita,S., Suo,S., Tomita,T., Iwatsubo,T. and Ishiura,S.
    Comparison of presenilin 1 and presenilin 2 gamma-secretase activities using a yeast reconstitution system
    J Biol Chem286, 44569-44575. PubMed  Europe PubMed DOI
    72. 2010
  72. Coen,K. and Annaert,W.
    Presenilins: how much more than gamma-secretase?!
    Biochem Soc Trans38, 1474-1478. PubMed  Europe PubMed DOI
  73. De Strooper,B. and Annaert,W.
    Novel research horizons for presenilins and gamma-secretases in cell biology and disease
    Annu Rev Cell Dev Biol26, 235-260. PubMed  Europe PubMed DOI  V
  74. Elder,G.A., Gama Sosa,M.A., De Gasperi,R., Dickstein,D.L. and Hof,P.R.
    Presenilin transgenic mice as models of Alzheimer's disease
    Brain Struct Funct214, 127-143. PubMed  Europe PubMed DOI  K
  75. Jayadev,S., Leverenz,J.B., Steinbart,E., Stahl,J., Klunk,W., Yu,C.E. and Bird,T.D.
    Alzheimer's disease phenotypes and genotypes associated with mutations in presenilin 2
    Brain133, 1143-1154. PubMed  Europe PubMed DOI  M
  76. Lessard,C.B., Wagner,S.L. and Koo,E.H.
    And four equals one: presenilin takes the gamma-secretase role by itself
    Proc Natl Acad Sci U S A107, 21236-21237. PubMed  Europe PubMed DOI
  77. Small,D.H., Klaver,D.W. and Foa,L.
    Presenilins and the gamma-secretase: still a complex problem
    Mol Brain3, 7-7. PubMed  Europe PubMed DOI  V
    78. 2009
  78. Brunello,L., Zampese,E., Florean,C., Pozzan,T., Pizzo,P. and Fasolato,C.
    Presenilin-2 dampens intracellular Ca2+ stores by increasing Ca2+ leakage and reducing Ca2+ uptake
    J Cell Mol Med13, 3358-3369. PubMed  Europe PubMed DOI
  79. Jiang,X., Zhang,D., Shi,J., Chen,Y., Zhang,P. and Mei,B.
    Increased inflammatory response both in brain and in periphery in presenilin 1 and presenilin 2 conditional double knock-out mice
    J Alzheimers Dis18, 515-523. PubMed  Europe PubMed DOI  K
  80. Newman,M., Tucker,B., Nornes,S., Ward,A. and Lardelli,M.
    Altering presenilin gene activity in zebrafish embryos causes changes in expression of genes with potential involvement in Alzheimer's disease pathogenesis
    J Alzheimers Dis16, 133-147. PubMed  Europe PubMed DOI  R
  81. Ounallah-Saad,H., Beeri,R., Goshen,I., Yirmiya,R., Renbaum,P. and Levy-Lahad,E.
    Transcriptional regulation of the murine presenilin-2 gene reveals similarities and differences to its human orthologue
    Gene446, 81-89. PubMed  Europe PubMed DOI  M
  82. Placanica,L., Tarassishin,L., Yang,G., Peethumnongsin,E., Kim,S.H., Zheng,H., Sisodia,S.S. and Li,Y.M.
    Pen2 and presenilin-1 modulate the dynamic equilibrium of presenilin-1 and presenilin-2 gamma-secretase complexes
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  83. Suzuki,Y., Ohta,K., Itoh,M., Sakoh-Sumitomo,Y., Mitsuda,T., Ueda,M., Hayakawa-Yano,Y., Li,S., Hida,Y., Inuzuka,T., Jung,Y.K. and Nakagawa,T.
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