Literature for family A1 unassigned peptidases

Summary Sequences Sequence features Distribution Literature

(Topics flags: P Specificity, I Inhibitor, E Expression. To select only the references relevant to a single topic, click the link above. See explanation.)

2024

Almuqdadi,H.T.A., Kifayat,S., Anwer,R., Alrehaili,J. and Abid,M. Fragment-based virtual screening identifies novel leads against Plasmepsin IX (PlmIX) of Plasmodium falciparum: Homology modeling, molecular docking, and simulation approaches Front Pharmacol (2024) 15, 1387629-1387629. PubMed Europe PubMed DOI PMC EPMC
Chua,W., Marsh,C.O., Poh,S.E., Koh,W.L., Lee,M.L.Y., Koh,L.F., Tang,X.E., See,P., Ser,Z., Wang,S.M., Sobota,R.M., Dawson,T.L., Jr., Yew,Y.W., Thng,S., O'Donoghue,A.J., Oon,H.H., Common,J.E. and Li,H. A Malassezia pseudoprotease dominates the secreted hydrolase landscape and is a potential allergen on skin Biochimie (2024) 216, 181-193. PubMed Europe PubMed DOI
Lisauskaite,M., Nixon,G.L., Woodley,C.M., Berry,N.G., Coninckx,A., Qie,L.C., Leung,S.C., Taramelli,D., Basilico,N., Parapini,S., Ward,S.A., Vadas,O., Soldati-Favre,D., Hong,W.D. and O'Neill,P.M. Design, synthesis and modelling of photoreactive chemical probes for investigating target engagement of plasmepsin IX and X in Plasmodium falciparum RSC Chem Biol (2024) 5, 19-29. PubMed Europe PubMed DOI PMC EPMC
Mishra,V., Deshmukh,A., Rathore,I., Chakraborty,S., Patankar,S., Gustchina,A., Wlodawer,A., Yada,R.Y. and Bhaumik,P. Inhibition of Plasmodium falciparum plasmepsins by drugs targeting HIV-1 protease: A way forward for antimalarial drug discovery Curr Res Struct Biol (2024) 7, 100128-100128. PubMed Europe PubMed DOI PMC EPMC I

2023

Charles,S. and Mahapatra,R.K. Artificial intelligence based de-novo design for novel Plasmodium falciparum plasmepsin (PM) X inhibitors J Biomol Struct Dyn (2023) , 1-16. PubMed Europe PubMed DOI

2020

Granato,M.Q., Sousa,I.S., Rosa,T.L.S.A., Goncalves,D.S., Seabra,S.H., Alviano,D.S., Pessolani,M.C.V., Santos,A.L.S. and Kneipp,L.F. Aspartic peptidase of Phialophora verrucosa as target of HIV peptidase inhibitors: blockage of its enzymatic activity and interference with fungal growth and macrophage interaction J Enzyme Inhib Med Chem (2020) 35, 629-638. PubMed Europe PubMed DOI I
Guo,Y., Tu,T., Zheng,J., Ren,Y., Wang,Y., Bai,Y., Su,X., Wang,Y., Yao,B., Huang,H. and Luo,H. A novel thermostable aspartic protease from Talaromyces leycettanus and its specific autocatalytic activation through an intermediate transition state Appl Microbiol Biotechnol (2020) 104, 4915-4926. PubMed Europe PubMed DOI
Pereira,W.E.S., da Silva,R.R., de Amo,G.S., Ruller,R., Kishi,L.T., Boscolo,M., Gomes,E. and da Silva,R. A collagenolytic aspartic protease from Thermomucor indicae-seudaticae expressed in Escherichia coli and Pichia pastoris Appl Biochem Biotechnol (2020) PubMed Europe PubMed DOI
Poh,S.E., Goh,J.P.Z., Fan,C., Chua,W., Gan,S.Q., Lim,P.L.K., Sharma,B., Leavesley,D.I., Dawson TL Jr and Li,H. Identification of Malassezia furfur secreted aspartyl protease 1 (MfSAP1) and its role in extracellular matrix degradation Front Cell Infect Microbiol (2020) 10, 148-148. PubMed Europe PubMed DOI PMC EPMC
Shimoda,Y., Nishigaya,Y., Yamaya-Ito,H., Inagaki,N., Umehara,Y., Hirakawa,H., Sato,S., Yamazaki,T. and Hayashi,M. The rhizobial autotransporter determines the symbiotic nitrogen fixation activity of Lotus japonicus in a host-specific manner Proc Natl Acad Sci U S A (2020) 117, 1806-1815. PubMed Europe PubMed DOI
Wang,X., Shi,Y., He,R., Li,B. and Huang,A. Label-free quantitative proteomic analysis of the biological functions of Moringa oleifera seed proteins provides insights regarding the milk-clotting proteases Int J Biol Macromol (2020) 144, 325-333. PubMed Europe PubMed DOI
Xu,J., Liu,R.D., Bai,S.J., Hao,H.N., Yue,W.W., Xu,Y.X.Y., Long,S.R., Cui,J. and Wang,Z.Q. Molecular characterization of a Trichinella spiralis aspartic protease and its facilitation role in larval invasion of host intestinal epithelial cells PLoS Negl Trop Dis (2020) 14, e0008269-e0008269. PubMed Europe PubMed DOI

2019

Guo,B., Wang,H., Yang,B., Jiang,W., Jing,M., Li,H., Xia,Y., Xu,Y., Hu,Q., Wang,F., Yu,F., Wang,Y., Ye,W., Dong,S., Xing,W. and Wang,Y. Phytophthora sojae effector PsAvh240 inhibits host aspartic protease secretion to promote infection Mol Plant (2019) 12, 552-564. PubMed Europe PubMed DOI
Guo,Y., Tu,T., Yuan,P., Wang,Y., Ren,Y., Yao,B. and Luo,H. High-level expression and characterization of a novel aspartic protease from Talaromyces leycettanus JCM12802 and its potential application in juice clarification Food Chem (2019) 281, 197-203. PubMed Europe PubMed DOI
Guo,Y., Tu,T., Zheng,J., Bai,Y., Huang,H., Su,X., Wang,Y., Wang,Y., Yao,B. and Luo,H. Improvement of BsAPA aspartic protease thermostability via autocatalysis-resistant mutation J Agric Food Chem (2019) 67, 10505-10512. PubMed Europe PubMed DOI
Gutierrez-Mendez,N., Balderrama-Carmona,A., Garcia-Sandoval,S.E., Ramirez-Vigil,P., Leal-Ramos,M.Y. and Garcia-Triana,A. Proteolysis and rheological properties of cream cheese made with a plant-derived coagulant from Solanum elaeagnifolium Foods (2019) 8 PubMed Europe PubMed DOI
Osuna-Ruiz,I., Espinoza-Marroquin,M.F., Salazar-Leyva,J.A., Pena,E., Alvarez-Gonzalez,C.A., Banuelos-Vargas,I. and Martinez-Montano,E. Biochemical characterization of a semi-purified aspartic protease from sea catfish Bagre panamensis with milk-clotting activity Food Sci Biotechnol (2019) 28, 1785-1793. PubMed Europe PubMed DOI PMC EPMC
Soares,A., Niedermaier,S., Faro,R., Loos,A., Manadas,B., Faro,C., Huesgen,P.F., Cheung,A.Y. and Simoes,I. An atypical aspartic protease modulates lateral root development in Arabidopsis thaliana J Exp Bot (2019) 70, 2157-2171. PubMed Europe PubMed DOI
Wan Zakaria,W.N.A., Aizat,W.M., Goh,H.H. and Mohd Noor,N. Protein replenishment in pitcher fluids of Nepenthes x ventrata revealed by quantitative proteomics (SWATH-MS) informed by transcriptomics J Plant Res (2019) 132, 681-694. PubMed Europe PubMed DOI

2018

Bialkowska,A.M., Krysiak,J., Florczak,T., Szulczewska,K.M., Wanarska,M. and Turkiewicz,M. The psychrotrophic yeast Sporobolomyces roseus LOCK 1119 as a source of a highly active aspartic protease for the in vitro production of antioxidant peptides Biotechnol Appl Biochem (2018) 65, 726-738. PubMed Europe PubMed DOI
Ianiri,G., Heitman,J. and Scheynius,A. The skin commensal yeast Malassezia globosa thwarts bacterial biofilms to benefit the host J Invest Dermatol (2018) 138, 1026-1029. PubMed Europe PubMed DOI
Lotfan,M., Choudhary,S., Yadav,M.L., Kumar,S., Singh,S., Bathla,S., Rawat,P., Kaushik,J.K. and Mohanty,A.K. Primary structures of different isoforms of buffalo pregnancy-associated glycoproteins (BuPAGs) during early pregnancy and elucidation of the 3-dimensional structure of the most abundant isoform BuPAG 7 PLoS ONE (2018) 13, e0206143-e0206143. PubMed Europe PubMed DOI
Santos,A.L.S., Matteoli,F.P., Sangenito,L.S., Branquinha,M.H., Cotrim,B.A. and Resende,G.O. Asymmetric peptidomimetics containing L-tartaric acid core inhibit the aspartyl peptidase activity and growth of Leishmania amazonensis promastigotes Acta Parasitol (2018) 63, 114-124. PubMed Europe PubMed DOI
Yamaya-Ito,H., Shimoda,Y., Hakoyama,T., Sato,S., Kaneko,T., Hossain,M.S., Shibata,S., Kawaguchi,M., Hayashi,M., Kouchi,H. and Umehara,Y. Loss-of-function of ASPARTIC PEPTIDASE NODULE-INDUCED 1 (APN1) in Lotus japonicus restricts efficient nitrogen-fixing symbiosis with specific Mesorhizobium loti strains Plant J (2018) 93, 5-16. PubMed Europe PubMed DOI

2017

Boddey,J.A. Plasmepsins on the antimalarial hit list Science (2017) 358, 445-446. PubMed Europe PubMed DOI I
Bryksa,B.C., Grahame,D.A. and Yada,R.Y. Comparative structure-function characterization of the saposin-like domains from potato, barley, cardoon and Arabidopsis aspartic proteases Biochim Biophys Acta (2017) 1859, 1008-1018. PubMed Europe PubMed DOI
Lipka,A., Majewska,M., Panasiewicz,G., Bieniek-Kobuszewska,M. and Szafranska,B. Gene structure of the pregnancy-associated glycoprotein-like (PAG-L) in the Eurasian beaver (Castor fiber L.) Funct Integr Genomics (2017) 17, 599-605. PubMed Europe PubMed DOI
Mastan,B.S., Narwal,S.K., Dey,S., Kumar,K.A. and Mishra,S. Plasmodium berghei plasmepsin VIII is essential for sporozoite gliding motility Int J Parasitol (2017) 47, 239-245. PubMed Europe PubMed DOI
Nasamu,A.S., Glushakova,S., Russo,I., Vaupel,B., Oksman,A., Kim,A.S., Fremont,D.H., Tolia,N., Beck,J.R., Meyers,M.J., Niles,J.C., Zimmerberg,J. and Goldberg,D.E. Plasmepsins IX and X are essential and druggable mediators of malaria parasite egress and invasion Science (2017) 358, 518-522. PubMed Europe PubMed DOI I
Salehi,M., Aghamaali,M.R., Sajedi,R.H., Asghari,S.M. and Jorjani,E. Purification and characterization of a milk-clotting aspartic protease from Withania coagulans fruit Int J Biol Macromol (2017) 98, 847-854. PubMed Europe PubMed DOI

2016

Burggraaf,A.M., Punt,P.J. and Ram,A.F. The unconventional secretion of PepN is independent of a functional autophagy machinery in the filamentous fungus Aspergillus niger FEMS Microbiol Lett (2016) 363, fnw152-fnw152. PubMed Europe PubMed DOI
Li,F., Bounkeua,V., Pettersen,K. and Vinetz,J.M. Plasmodium falciparum ookinete expression of plasmepsin VII and plasmepsin X Malar J (2016) 15, 111-111. PubMed Europe PubMed DOI PMC EPMC
Mandujano-Gonzalez,V., Tellez-Jurado,A., Anducho-Reyes,M.A., Arana-Cuenca,A. and Mercado-Flores,Y. Purification and characterization of the extracellular aspartyl protease APSm1 from the phytopathogen fungus Stenocarpella maydis Protein Expr Purif (2016) 117, 1-5. PubMed Europe PubMed DOI

2014

Beigomi,M., Mohammadifar,M.A., Hashemi,M., Rohani,M.G., Senthil,K. and Valizadeh,M. Biochemical and rheological characterization of a protease from fruits of Withania coagulans with a milk-clotting activity Food Sci Biotechnol (2014) 23, 1805-1813. DOI
Mastan,B.S., Kumari,A., Gupta,D., Mishra,S. and Kumar,K.A. Gene disruption reveals a dispensable role for plasmepsin VII in the Plasmodium berghei life cycle Mol Biochem Parasitol (2014) 195, 10-13. PubMed Europe PubMed DOI

2013

Aoki,K., Matsubara,S., Umeda,M., Tachibanac,S., Doi,M. and Takenaka,S. Aspartic protease from Aspergillus (Eurotium) repens strain MK82 is involved in the hydrolysis and decolourisation of dried bonito (Katsuobushi) J Sci Food Agric (2013) 93, 1349-1355. PubMed Europe PubMed DOI P
Huang,J., Zhao,X., Cheng,K., Jiang,Y., Ouyang,Y., Xu,C., Li,X., Xiao,J. and Zhang,Q. OsAP65, a rice aspartic protease, is essential for male fertility and plays a role in pollen germination and pollen tube growth J Exp Bot (2013) 64, 3351-3360. PubMed Europe PubMed DOI PMC EPMC

2012

Balczun,C., Siemanowski,J., Pausch,J.K., Helling,S., Marcus,K., Stephan,C., Meyer,H.E., Schneider,T., Cizmowski,C., Oldenburg,M., Hohn,S., Meiser,C.K., Schuhmann,W. and Schaub,G.A. Intestinal aspartate proteases TiCatD and TiCatD2 of the haematophagous bug Triatoma infestans (Reduviidae): sequence characterisation, expression pattern and characterisation of proteolytic activity Insect Biochem Mol Biol (2012) 42, 240-250. PubMed Europe PubMed DOI

2011

Abd El-Baky,H., Linke,D., Nimtz,M., Metry,W., El-Demerdash,O. and Berger,R.G. The extracellular aspartic peptidase of basidiomycete Wolfiporia cocos is a highly efficient milk clotting enzyme Milchwissenschaft (2011) 66, 406-409.

2010

Cho,E.Y., Cheon,S.A., Kim,H., Choo,J., Lee,D.J., Ryu,H.M., Rhee,S.K., Chung,B.H., Kim,J.Y. and Kang,H.A. Multiple-yapsin-deficient mutant strains for high-level production of intact recombinant proteins in Saccharomyces cerevisiae J Biotechnol (2010) 149, 1-7. PubMed Europe PubMed DOI

2009

Takahashi,K., Matsumoto,K., Nishii,W., Muramatsu,M., Kubota,K., Shibata,C. and Athauda,S.B.P. Comparative studies on the acid protenase activities in the digestive fluids of Nepenthes, Cephalotus, Dionaea, and Drosera Carniv Pl Newsletter (2009) 38, 75-82.

1986

Yamashita,I., Hirata,D., Machida,M. and Fukui,S. Cloning and expression in Saccharomyces cerevisiae of the secretable acid protease gene from Saccharomycopsis fibuligera Agric Biol Chem (1986) 50, 109-113. DOI E