Literature for subfamily A1A unassigned peptidases

Summary Sequences Sequence features Distribution Structure Literature Substrates

(Topics flags: I Inhibitor, P Specificity, K Knockout, E Expression. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Colombo,M.L., Fernandez,A., Liggieri,C.S., Tornero,P., Bakas,L.S. and Vairo-Cavalli,S.E.
    Aspartic proteases from Silybum marianum: different plant-specific inserts, different destinations
    Planta261, 117-117. PubMed  Europe PubMed DOI
  2. 2024
  3. Li,W., Li,P., Deng,Y., Zhang,Z., Situ,J., Huang,J., Li,M., Xi,P., Jiang,Z. and Kong,G.
    Litchi aspartic protease LcAP1 enhances plant resistance via suppressing cell death triggered by the pectate lyase PlPeL8 from Peronophythora litchii
    New Phytol242, 2682-2701. PubMed  Europe PubMed DOI
  4. Lim,S.J., Noor,N.D.M., Sabri,S., Ali,M.S.M., Salleh,A.B. and Oslan,S.N.
    Extracellular BSA-degrading SAPs in the rare pathogen Meyerozyma guilliermondii strain SO as potential virulence factors in candidiasis
    Microb Pathog193, 106773-106773. PubMed  Europe PubMed DOI
  5. Xue,Y., Yan,Q., Tian,X., Han,D. and Jiang,Z.
    High-level secretory expression and characterization of acid protease in Komagataella phaffii and its application in soybean meal protein degradation
    Int J Biol Macromol137011-137011. PubMed  Europe PubMed DOI
  6. 2023
  7. Kim,J.S., Lee,K.T. and Bahn,Y.S.
    Secreted aspartyl protease 3 regulated by the Ras/cAMP/PKA pathway promotes the virulence of Candida auris
    Front Cell Infect Microbiol13, 1257897-1257897. PubMed  Europe PubMed DOI
  8. 2022
  9. Qin,S., Zhu,B., Huang,X., Hull,J.J., Chen,L. and Luo,J.
    Functional Role of AsAP in the Reproduction of Adelphocoris suturalis (Hemiptera: Miridae)
    Insects13, PubMed  Europe PubMed DOI  K
  10. 2021
  11. Kang,J.M., Le,H.G., Na,B.K. and Yoo,W.G.
    pH-Dependent Structural Dynamics of Cathepsin D-Family Aspartic Peptidase of Clonorchis sinensis
    Pathogens10, PubMed  Europe PubMed DOI
  12. Snebergerova,P., Bartosova-Sojkova,P., Jalovecka,M. and Sojka,D.
    Plasmepsin-like Aspartyl Proteases in Babesia
    Pathogens10, PubMed  Europe PubMed DOI
  13. 2020
  14. Ramos,L.S., Oliveira,S.S.C., Braga-Silva,L.A., Branquinha,M.H. and Santos,A.L.S.
    Secreted aspartyl peptidases by the emerging, opportunistic and multidrug-resistant fungal pathogens comprising the Candida haemulonii complex
    Fungal Biol124, 700-707. PubMed  Europe PubMed DOI
  15. Sukonset,C., Surinlert,P., Thongsum,O., Watthammawut,A., Somrit,M., Nakeim,J., Weerachatyanukul,W. and Asuvapongpatana,S.
    Cathepsin D in prawn reproductive system: its localization and function in actin degradation
    PeerJ8, e10218-e10218. PubMed  Europe PubMed DOI
  16. Xu,X., Wang,C., Huang,Y., Zhang,S., Yu,H., Meng,J. and Pan,B.
    Evaluation of the vaccine efficacy of three digestive protease antigens from Dermanyssus gallinae using an in vivo rearing system
    Vaccine38, 7842-7849. PubMed  Europe PubMed DOI
  17. 2018
  18. Mancilla-Olea,M.I., Ortega-Lopez,J., Figueroa-Angulo,E.E., Avila-Gonzalez,L., Cardenas-Guerra,R.E., Miranda-Ozuna,J.F.T., Gonzalez-Robles,A., Hernandez-Garcia,M.S., Sanchez-Ayala,L. and Arroyo,R.
    Trichomonas vaginalis cathepsin D-like aspartic proteinase (Tv-CatD) is positively regulated by glucose and degrades human hemoglobin
    Int J Biochem Cell Biol97, 1-15. PubMed  Europe PubMed DOI
  19. Theron,L.W., Bely,M. and Divol,B.
    Monitoring the impact of an aspartic protease (MpAPr1) on grape proteins and wine properties
    Appl Microbiol Biotechnol102, 5173-5183. PubMed  Europe PubMed DOI
  20. 2017
  21. Theron,L.W., Bely,M. and Divol,B.
    Characterisation of the enzymatic properties of MpAPr1, an aspartic protease secreted by the wine yeast Metschnikowia pulcherrima
    J Sci Food Agric97, 3584-3593. PubMed  Europe PubMed DOI
  22. 2016
  23. Clarke,S.C., Dumesic,P.A., Homer,C.M., O'Donoghue,A.J., La Greca,F., Pallova,L., Majer,P., Madhani,H.D. and Craik,C.S.
    Integrated activity and genetic profiling of secreted peptidases in Cryptococcus neoformans reveals an aspartyl peptidase required for low pH survival and virulence
    PLoS Pathog12, e1006051-e1006051. PubMed  Europe PubMed DOI
  24. 2013
  25. Mandujano-Gonzalez,V., Arana-Cuenca,A., Anducho-Reyes,M.A., Tellez-Jurado,A., Gonzalez-Becerra,A.E. and Mercado-Flores,Y.
    Biochemical study of the extracellular aspartyl protease Eap1 from the phytopathogen fungus Sporisorium reilianum
    Protein Expr Purif92, 214-222. PubMed  Europe PubMed DOI
  26. Rojo,L., Garcia-Carreno,F. and de Los Angeles Navarrete Del Toro
    Cold-adapted digestive aspartic protease of the clawed lobsters Homarus americanus and Homarus gammarus: biochemical characterization
    Mar Biotechnol (NY)15, 87-96. PubMed  Europe PubMed DOI
  27. Yu,X.J., Chi,Z., Wang,F., Li,J., Chi,Z.M. and Madzak,C.
    Expression of the acid protease gene from Saccharomycopsis fibuligera in the marine-derived Yarrowia lipolytica for both milk clotting and single cell protein production
    Appl Biochem Biotechnol169, 1993-2003. PubMed  Europe PubMed DOI  E
  28. 2012
  29. Sojka,D., Franta,Z., Frantova,H., Bartosova,P., Horn,M., Vachova,J., O'Donoghue,A.J., Eroy-Reveles,A.A., Craik,C.S., Knudsen,G.M., Caffrey,C.R., McKerrow,J.H., Mares,M. and Kopacek,P.
    Characterization of gut-associated cathepsin D hemoglobinase from tick Ixodes ricinus (IrCD1)
    J Biol Chem287, 21152-21163. PubMed  Europe PubMed DOI  P
  30. 2011
  31. El-Baky,H.A., Linke,D., Nimtz,M. and Berger,R.G.
    PsoP1, a milk-clotting aspartic peptidase from the basidiomycete fungus Piptoporus soloniensis
    J Agric Food Chem59, 10311-10316. PubMed  Europe PubMed DOI
  32. Rao,S., Mizutani,O., Hirano,T., Masaki,K. and Iefuji,H.
    Purification and characterization of a novel aspartic protease from basidiomycetous yeast Cryptococcus sp. S-2
    J Biosci Bioeng112, 441-446. PubMed  Europe PubMed DOI
  33. 2010
  34. Gomes,F.M., Oliveira,D.M., Motta,L.S., Ramos,I.B., Miranda,K.M. and Machado,E.A.
    Inorganic polyphosphate inhibits an aspartic protease-like activity in the eggs of Rhodnius prolixus (Stahl) and impairs yolk mobilization in vitro
    J Cell Physiol222, 606-611. PubMed  Europe PubMed DOI
  35. Rojo,L., Muhlia-Almazan,A., Saborowski,R. and Garcia-Carreno,F.
    Aspartic cathepsin D endopeptidase contributes to extracellular digestion in clawed lobsters Homarus americanus and Homarus gammarus
    Mar Biotechnol (NY)12, 696-707. PubMed  Europe PubMed DOI
  36. ten Have,A., Espino,J.J., Dekkers,E., Van Sluyter,S.C., Brito,N., Kay,J., Gonzalez,C. and van Kan,J.A.
    The Botrytis cinerea aspartic proteinase family
    Fungal Genet Biol47, 53-65. PubMed  Europe PubMed DOI
  37. 2009
  38. Mello,L.V., O'Meara,H., Rigden,D.J. and Paterson,S.
    Identification of novel aspartic proteases from Strongyloides ratti and characterisation of their evolutionary relationships, stage-specific expression and molecular structure
    BMC Genomics10, 611-611. PubMed  Europe PubMed DOI
  39. 2007
  40. Tanji,M., Yakabe,E., Kageyama,T., Yokobori,S., Ichinose,M., Miki,K., Ito,H. and Takahashi,K.
    Purification and characterization of pepsinogens from the gastric mucosa of African coelacanth, Latimeria chalumnae, and properties of the major pepsins
    Comp Biochem Physiol B Biochem Mol Biol146, 412-420. PubMed  Europe PubMed DOI
  41. Zhou,Q., Fu,X.P., Zhang,L.J., Su,W.J. and Cao,M.J.
    Purification and characterization of sea bream (Sparus latus Houttuyn) pepsinogens and pepsins
    Food Chem103, 795-801. DOI
  42. 2006
  43. Lochnit,G., Grabitzki,J., Henkel,B., Tavernarakis,N. and Geyer,R.
    First identification of a phosphorylcholine-substituted protein from Caenorhabditis elegans: isolation and characterization of the aspartyl protease ASP-6
    Biol Chem387, 1487-1493. PubMed  Europe PubMed DOI
  44. Navarrete del Toro,M., Garcia-Carreno,F., Lopez,M.D., Celis-Guerrero,L. and Saborowski,R.
    Aspartic proteinases in the digestive tract of marine decapod crustaceans
    J Exp Zoolog Part A Comp Exp Biol305, 645-654. PubMed  Europe PubMed DOI
  45. 2005
  46. [YEAR:14-7-2005]Klemba,M. and Goldberg,D.E.
    Characterization of plasmepsin V, a membrane-bound aspartic protease homolog in the endoplasmic reticulum of Plasmodium falciparum
    Mol Biochem Parasitol143, 183-191. PubMed  Europe PubMed DOI
  47. Kotani,N., Kitazume,S., Kamimura,K., Takeo,S., Aigaki,T., Nakato,H. and Hashimoto,Y.
    Characterization of Drosophila aspartic proteases that induce the secretion of a Golgi-resident transferase, heparan sulfate 6-O-sulfotransferase
    J Biochem137, 315-322. PubMed  Europe PubMed DOI
  48. Mercado-Flores,Y., Trejo-Aguilar,A., Ramirez-Zavala,B., Villa-Tanaca,L. and Hernandez-Rodriguez,C.
    Purification and characterization of an intracellular aspartyl acid proteinase (pumAi) from Ustilago maydis
    Can J Microbiol51, 171-175. PubMed  Europe PubMed DOI
  49. 2004
  50. ten Have,A., Dekkers,E., Kay,J., Phylip,L.H. and van Kan,J.A.
    An aspartic proteinase gene family in the filamentous fungus Botrytis cinerea contains members with novel features
    Microbiology (Reading, Engl )150, 2475-2489. PubMed  Europe PubMed DOI
  51. 2003
  52. Smith,W.D., Skuce,P.J., Newlands,G.F., Smith,S.K. and Pettit,D.
    Aspartyl proteases from the intestinal brush border of Haemonchus contortus as protective antigens for sheep
    Parasite Immunol25, 521-530. PubMed  Europe PubMed DOI
  53. 2002
  54. [YEAR:31-10-2002]Syntichaki,P., Xu,K., Driscoll,M. and Tavernarakis,N.
    Specific aspartyl and calpain proteases are required for neurodegeneration in C. elegans
    Nature419, 939-944. PubMed  Europe PubMed DOI
  55. 2001
  56. Nehls,U., Bock,A., Einig,W. and Hampp,R.
    Excretion of two proteases by the ectomycorrhizal fungus Amanita muscaria
    Plant Cell Environ24, 741-747.
  57. 2000
  58. [YEAR:25-8-2000]Tcherepanova,I., Bhattacharyya,L., Rubin,C.S. and Freedman,J.H.
    Aspartic proteases from the nematode Caenorhabditis elegans. Structural organization and developmental and cell-specific expression of asp-1
    J Biol Chem275, 26359-26369. PubMed  Europe PubMed DOI
  59. 1999
  60. Bang,M.L., Villadsen,I. and Sandal,T.
    Cloning and characterization of an endo-beta-1,3(4)glucanase and an aspartic protease from Phaffia rhodozyma CBS 6938
    Appl Microbiol Biotechnol51, 215-222. PubMed  Europe PubMed DOI
  61. Geier,G., Banaj,H.J., Heid,H., Bini,L., Pallini,V. and Zwilling,R.
    Aspartyl proteases in Caenorhabditis elegans. Isolation, identification and characterization by a combined use of affinity chromatography, two-dimensional gel electrophoresis, microsequencing and databank analysis
    Eur J Biochem264, 872-879. PubMed  Europe PubMed DOI
  62. 1998
  63. [YEAR:15-8-1998]Gallego,S.G., Slade,R.W. and Brindley,P.J.
    A cDNA encoding a pepsinogen-like, aspartic protease from the human roundworm parasite Strongyloides stercoralis
    Acta Trop71, 17-26. PubMed  Europe PubMed DOI
  64. 1997
  65. Longbottom,D., Redmond,D.L., Russell,M., Liddell,S., Smith,W.D. and Knox,D.P.
    Molecular cloning and characterisation of a putative aspartate proteinase associated with a gut membrane protein complex from adult Haemonchus contortus
    Mol Biochem Parasitol88, 63-72. PubMed  Europe PubMed DOI
  66. 1996
  67. De Vicente,J.I., De Arriaga,D., Del Valle,P., Soler,J. and Eslava,A.P.
    Purification and characterization of an extracellular aspartate protease from Phycomyces blakesleeanus
    Fungal Genet Biol20, 115-124. PubMed  Europe PubMed DOI
  68. 1993
  69. Fusek,M., Smith,E.A., Monod,M. and Foundling,S.I.
    Candida parapsilosis expresses and secretes two aspartic proteinases
    FEBS Lett327, 108-112. PubMed  Europe PubMed DOI
  70. 1988
  71. Hirata,D., Fukui,S. and Yamashita,I.
    Nucleotide sequence of the secretable acid protease gene PEPI in the yeast Saccharomycopsis fibuligera
    Agric Biol Chem52, 2647-2649.
  72. 1983
  73. [YEAR:16-5-1983]Kolaczkowska,M.K., Wieczorek,M. and Polanowski,A.
    An aspartic proteinase from Fusarium moniliforme. Purification and general properties
    Eur J Biochem132, 557-561. PubMed  Europe PubMed  I
  74. Kuczek,M., Nowak,K. and Kolaczkowska,M.
    Specificity of acid protease from Fusarium moniliforme
    Acta Biochim Pol30, 3-10. PubMed  Europe PubMed