Merops Switch to
Inhibitors

Peptidase

Family Clan SEARCHES BLAST
MEROPS SUBMISSIONS

Other
information

Literature for subfamily A1A unassigned peptidases

Summary Sequences Sequence features Distribution Structure Literature Substrates

(Topics flags: I Inhibitor, P Specificity, K Knockout, E Expression, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2026
  1. Chen,W., Defty,N.R., Bartley,K., Nunn,F., Schiavone,A., Bowman,A.S., Hayward,A.D., Burgess,S.T.G., Nisbet,A.J. and Price,D.R.G.<br>RNAi-mediated knockdown of the poultry red mite cathepsin D-1 impacts haemoglobin digestion<br>Parasit Vectors (2026) PubMed  Europe PubMed DOI
    2. 2025
  2. Chua,W., Hei,Y., Koh,L.F., Yap,B.L.H., Saw,H.L., Fernandes,T.H.M., da Silva,E.B., Goh,S., Dawson,T.L., Jr., O'Donoghue,A.J., Common,J.E. and Li,H.<br>Aspartyl protease MfSAP2 is a key virulence factor in mycelial form of skin fungi Malassezia furfur<br>Biochem J (2025) PubMed  Europe PubMed DOI
  3. Colombo,M.L., Fernandez,A., Liggieri,C.S., Tornero,P., Bakas,L.S. and Vairo-Cavalli,S.E.<br>Aspartic proteases from Silybum marianum: different plant-specific inserts, different destinations<br>Planta (2025) 261, 117-117. PubMed  Europe PubMed DOI
  4. Xu,X., Liu,Y., Li,X., Zhang,P., Lin,F., Chen,C., Zhang,X., Li,C. and Fu,Q.<br>Characterization, expression profiling, and immunological role of Cathepsin D in Sebastes schlegelii during bacterial infection<br>Dev Comp Immunol (2025) 167, 105387-105387. PubMed  Europe PubMed DOI
    5. 2024
  5. Li,W., Li,P., Deng,Y., Zhang,Z., Situ,J., Huang,J., Li,M., Xi,P., Jiang,Z. and Kong,G.<br>Litchi aspartic protease LcAP1 enhances plant resistance via suppressing cell death triggered by the pectate lyase PlPeL8 from Peronophythora litchii<br>New Phytol (2024) 242, 2682-2701. PubMed  Europe PubMed DOI
  6. Lim,S.J., Noor,N.D.M., Sabri,S., Ali,M.S.M., Salleh,A.B. and Oslan,S.N.<br>Extracellular BSA-degrading SAPs in the rare pathogen Meyerozyma guilliermondii strain SO as potential virulence factors in candidiasis<br>Microb Pathog (2024) 193, 106773-106773. PubMed  Europe PubMed DOI
  7. Liu,X.H., Liu,X.T., Wu,Y., Li,S.A., Ren,K.D., Cheng,M., Huang,B., Yang,Y. and Liu,P.P.<br>Broadening Horizons: Exploring the Cathepsin Family as Therapeutic Targets for Alzheimer's Disease<br>Aging Dis (2024) PubMed  Europe PubMed DOI  V
  8. Xue,Y., Yan,Q., Tian,X., Han,D. and Jiang,Z.<br>High-level secretory expression and characterization of acid protease in Komagataella phaffii and its application in soybean meal protein degradation<br>Int J Biol Macromol (2024) , 137011-137011. PubMed  Europe PubMed DOI
    9. 2023
  9. Kim,J.S., Lee,K.T. and Bahn,Y.S.<br>Secreted aspartyl protease 3 regulated by the Ras/cAMP/PKA pathway promotes the virulence of Candida auris<br>Front Cell Infect Microbiol (2023) 13, 1257897-1257897. PubMed  Europe PubMed DOI  PMC  EPMC
    10. 2022
  10. Qasim,F., Diercks-Horn,S., Gerlach,D., Schneider,A. and Fernandez-Lahore,H.M.<br>Production of a novel milk-clotting enzyme from solid-substrate Mucor spp. culture<br>J Food Sci (2022) 87, 4348-4362. PubMed  Europe PubMed DOI
  11. Qin,S., Zhu,B., Huang,X., Hull,J.J., Chen,L. and Luo,J.<br>Functional Role of AsAP in the Reproduction of Adelphocoris suturalis (Hemiptera: Miridae)<br>Insects (2022) 13 PubMed  Europe PubMed DOI  PMC  EPMC  K
    12. 2021
  12. Kang,J.M., Le,H.G., Na,B.K. and Yoo,W.G.<br>pH-Dependent Structural Dynamics of Cathepsin D-Family Aspartic Peptidase of Clonorchis sinensis<br>Pathogens (2021) 10 PubMed  Europe PubMed DOI  PMC  EPMC
  13. Snebergerova,P., Bartosova-Sojkova,P., Jalovecka,M. and Sojka,D.<br>Plasmepsin-like Aspartyl Proteases in Babesia<br>Pathogens (2021) 10 PubMed  Europe PubMed DOI  PMC  EPMC
    14. 2020
  14. Ramos,L.S., Oliveira,S.S.C., Braga-Silva,L.A., Branquinha,M.H. and Santos,A.L.S.<br>Secreted aspartyl peptidases by the emerging, opportunistic and multidrug-resistant fungal pathogens comprising the Candida haemulonii complex<br>Fungal Biol (2020) 124, 700-707. PubMed  Europe PubMed DOI
  15. Sukonset,C., Surinlert,P., Thongsum,O., Watthammawut,A., Somrit,M., Nakeim,J., Weerachatyanukul,W. and Asuvapongpatana,S.<br>Cathepsin D in prawn reproductive system: its localization and function in actin degradation<br>PeerJ (2020) 8, e10218-e10218. PubMed  Europe PubMed DOI  PMC  EPMC
  16. Xu,X., Wang,C., Huang,Y., Zhang,S., Yu,H., Meng,J. and Pan,B.<br>Evaluation of the vaccine efficacy of three digestive protease antigens from Dermanyssus gallinae using an in vivo rearing system<br>Vaccine (2020) 38, 7842-7849. PubMed  Europe PubMed DOI
    17. 2018
  17. Mancilla-Olea,M.I., Ortega-Lopez,J., Figueroa-Angulo,E.E., Avila-Gonzalez,L., Cardenas-Guerra,R.E., Miranda-Ozuna,J.F.T., Gonzalez-Robles,A., Hernandez-Garcia,M.S., Sanchez-Ayala,L. and Arroyo,R.<br>Trichomonas vaginalis cathepsin D-like aspartic proteinase (Tv-CatD) is positively regulated by glucose and degrades human hemoglobin<br>Int J Biochem Cell Biol (2018) 97, 1-15. PubMed  Europe PubMed DOI
  18. Theron,L.W., Bely,M. and Divol,B.<br>Monitoring the impact of an aspartic protease (MpAPr1) on grape proteins and wine properties<br>Appl Microbiol Biotechnol (2018) 102, 5173-5183. PubMed  Europe PubMed DOI
    19. 2017
  19. Theron,L.W., Bely,M. and Divol,B.<br>Characterisation of the enzymatic properties of MpAPr1, an aspartic protease secreted by the wine yeast Metschnikowia pulcherrima<br>J Sci Food Agric (2017) 97, 3584-3593. PubMed  Europe PubMed DOI
    20. 2016
  20. Clarke,S.C., Dumesic,P.A., Homer,C.M., O'Donoghue,A.J., La Greca,F., Pallova,L., Majer,P., Madhani,H.D. and Craik,C.S.<br>Integrated activity and genetic profiling of secreted peptidases in Cryptococcus neoformans reveals an aspartyl peptidase required for low pH survival and virulence<br>PLoS Pathog (2016) 12, e1006051-e1006051. PubMed  Europe PubMed DOI  PMC  EPMC
    21. 2013
  21. Mandujano-Gonzalez,V., Arana-Cuenca,A., Anducho-Reyes,M.A., Tellez-Jurado,A., Gonzalez-Becerra,A.E. and Mercado-Flores,Y.<br>Biochemical study of the extracellular aspartyl protease Eap1 from the phytopathogen fungus Sporisorium reilianum<br>Protein Expr Purif (2013) 92, 214-222. PubMed  Europe PubMed DOI
  22. Rojo,L., Garcia-Carreno,F. and de Los Angeles Navarrete Del Toro<br>Cold-adapted digestive aspartic protease of the clawed lobsters Homarus americanus and Homarus gammarus: biochemical characterization<br>Mar Biotechnol (NY) (2013) 15, 87-96. PubMed  Europe PubMed DOI
  23. Yu,X.J., Chi,Z., Wang,F., Li,J., Chi,Z.M. and Madzak,C.<br>Expression of the acid protease gene from Saccharomycopsis fibuligera in the marine-derived Yarrowia lipolytica for both milk clotting and single cell protein production<br>Appl Biochem Biotechnol (2013) 169, 1993-2003. PubMed  Europe PubMed DOI  E
    24. 2012
  24. Sojka,D., Franta,Z., Frantova,H., Bartosova,P., Horn,M., Vachova,J., O'Donoghue,A.J., Eroy-Reveles,A.A., Craik,C.S., Knudsen,G.M., Caffrey,C.R., McKerrow,J.H., Mares,M. and Kopacek,P.<br>Characterization of gut-associated cathepsin D hemoglobinase from tick Ixodes ricinus (IrCD1)<br>J Biol Chem (2012) 287, 21152-21163. PubMed  Europe PubMed DOI  P
    25. 2011
  25. El-Baky,H.A., Linke,D., Nimtz,M. and Berger,R.G.<br>PsoP1, a milk-clotting aspartic peptidase from the basidiomycete fungus Piptoporus soloniensis<br>J Agric Food Chem (2011) 59, 10311-10316. PubMed  Europe PubMed DOI
  26. Rao,S., Mizutani,O., Hirano,T., Masaki,K. and Iefuji,H.<br>Purification and characterization of a novel aspartic protease from basidiomycetous yeast Cryptococcus sp. S-2<br>J Biosci Bioeng (2011) 112, 441-446. PubMed  Europe PubMed DOI
    27. 2010
  27. Gomes,F.M., Oliveira,D.M., Motta,L.S., Ramos,I.B., Miranda,K.M. and Machado,E.A.<br>Inorganic polyphosphate inhibits an aspartic protease-like activity in the eggs of Rhodnius prolixus (Stahl) and impairs yolk mobilization in vitro<br>J Cell Physiol (2010) 222, 606-611. PubMed  Europe PubMed DOI
  28. Rojo,L., Muhlia-Almazan,A., Saborowski,R. and Garcia-Carreno,F.<br>Aspartic cathepsin D endopeptidase contributes to extracellular digestion in clawed lobsters Homarus americanus and Homarus gammarus<br>Mar Biotechnol (NY) (2010) 12, 696-707. PubMed  Europe PubMed DOI
  29. ten Have,A., Espino,J.J., Dekkers,E., Van Sluyter,S.C., Brito,N., Kay,J., Gonzalez,C. and van Kan,J.A.<br>The Botrytis cinerea aspartic proteinase family<br>Fungal Genet Biol (2010) 47, 53-65. PubMed  Europe PubMed DOI
    30. 2009
  30. Mello,L.V., O'Meara,H., Rigden,D.J. and Paterson,S.<br>Identification of novel aspartic proteases from Strongyloides ratti and characterisation of their evolutionary relationships, stage-specific expression and molecular structure<br>BMC Genomics (2009) 10, 611-611. PubMed  Europe PubMed DOI
    31. 2007
  31. Tanji,M., Yakabe,E., Kageyama,T., Yokobori,S., Ichinose,M., Miki,K., Ito,H. and Takahashi,K.<br>Purification and characterization of pepsinogens from the gastric mucosa of African coelacanth, Latimeria chalumnae, and properties of the major pepsins<br>Comp Biochem Physiol B Biochem Mol Biol (2007) 146, 412-420. PubMed  Europe PubMed DOI
  32. Zhou,Q., Fu,X.P., Zhang,L.J., Su,W.J. and Cao,M.J.<br>Purification and characterization of sea bream (Sparus latus Houttuyn) pepsinogens and pepsins<br>Food Chem (2007) 103, 795-801. DOI
    33. 2006
  33. Lochnit,G., Grabitzki,J., Henkel,B., Tavernarakis,N. and Geyer,R.<br>First identification of a phosphorylcholine-substituted protein from Caenorhabditis elegans: isolation and characterization of the aspartyl protease ASP-6<br>Biol Chem (2006) 387, 1487-1493. PubMed  Europe PubMed DOI
  34. Navarrete del Toro,M., Garcia-Carreno,F., Lopez,M.D., Celis-Guerrero,L. and Saborowski,R.<br>Aspartic proteinases in the digestive tract of marine decapod crustaceans<br>J Exp Zoolog Part A Comp Exp Biol (2006) 305, 645-654. PubMed  Europe PubMed DOI
    35. 2005
  35. [YEAR:14-7-2005]Klemba,M. and Goldberg,D.E.<br>Characterization of plasmepsin V, a membrane-bound aspartic protease homolog in the endoplasmic reticulum of Plasmodium falciparum<br>Mol Biochem Parasitol (14-7-2005) 143, 183-191. PubMed  Europe PubMed DOI
  36. Kotani,N., Kitazume,S., Kamimura,K., Takeo,S., Aigaki,T., Nakato,H. and Hashimoto,Y.<br>Characterization of Drosophila aspartic proteases that induce the secretion of a Golgi-resident transferase, heparan sulfate 6-O-sulfotransferase<br>J Biochem (2005) 137, 315-322. PubMed  Europe PubMed DOI
  37. Mercado-Flores,Y., Trejo-Aguilar,A., Ramirez-Zavala,B., Villa-Tanaca,L. and Hernandez-Rodriguez,C.<br>Purification and characterization of an intracellular aspartyl acid proteinase (pumAi) from Ustilago maydis<br>Can J Microbiol (2005) 51, 171-175. PubMed  Europe PubMed DOI
    38. 2004
  38. ten Have,A., Dekkers,E., Kay,J., Phylip,L.H. and van Kan,J.A.<br>An aspartic proteinase gene family in the filamentous fungus Botrytis cinerea contains members with novel features<br>Microbiology (Reading, Engl.) (2004) 150, 2475-2489. PubMed  Europe PubMed DOI
    39. 2003
  39. Smith,W.D., Skuce,P.J., Newlands,G.F., Smith,S.K. and Pettit,D.<br>Aspartyl proteases from the intestinal brush border of Haemonchus contortus as protective antigens for sheep<br>Parasite Immunol (2003) 25, 521-530. PubMed  Europe PubMed DOI
    40. 2002
  40. [YEAR:31-10-2002]Syntichaki,P., Xu,K., Driscoll,M. and Tavernarakis,N.<br>Specific aspartyl and calpain proteases are required for neurodegeneration in C. elegans<br>Nature (31-10-2002) 419, 939-944. PubMed  Europe PubMed DOI
    41. 2001
  41. Nehls,U., Bock,A., Einig,W. and Hampp,R.<br>Excretion of two proteases by the ectomycorrhizal fungus Amanita muscaria<br>Plant Cell Environ (2001) 24, 741-747.
    42. 2000
  42. [YEAR:25-8-2000]Tcherepanova,I., Bhattacharyya,L., Rubin,C.S. and Freedman,J.H.<br>Aspartic proteases from the nematode Caenorhabditis elegans. Structural organization and developmental and cell-specific expression of asp-1<br>J Biol Chem (25-8-2000) 275, 26359-26369. PubMed  Europe PubMed DOI
    43. 1999
  43. Bang,M.L., Villadsen,I. and Sandal,T.<br>Cloning and characterization of an endo-beta-1,3(4)glucanase and an aspartic protease from Phaffia rhodozyma CBS 6938<br>Appl Microbiol Biotechnol (1999) 51, 215-222. PubMed  Europe PubMed DOI
  44. Geier,G., Banaj,H.J., Heid,H., Bini,L., Pallini,V. and Zwilling,R.<br>Aspartyl proteases in Caenorhabditis elegans. Isolation, identification and characterization by a combined use of affinity chromatography, two-dimensional gel electrophoresis, microsequencing and databank analysis<br>Eur J Biochem (1999) 264, 872-879. PubMed  Europe PubMed DOI
    45. 1998
  45. [YEAR:15-8-1998]Gallego,S.G., Slade,R.W. and Brindley,P.J.<br>A cDNA encoding a pepsinogen-like, aspartic protease from the human roundworm parasite Strongyloides stercoralis <br>Acta Trop (15-8-1998) 71, 17-26. PubMed  Europe PubMed DOI
    46. 1997
  46. Longbottom,D., Redmond,D.L., Russell,M., Liddell,S., Smith,W.D. and Knox,D.P.<br>Molecular cloning and characterisation of a putative aspartate proteinase associated with a gut membrane protein complex from adult Haemonchus contortus<br>Mol Biochem Parasitol (1997) 88, 63-72. PubMed  Europe PubMed DOI
    47. 1996
  47. De Vicente,J.I., De Arriaga,D., Del Valle,P., Soler,J. and Eslava,A.P.<br>Purification and characterization of an extracellular aspartate protease from Phycomyces blakesleeanus<br>Fungal Genet Biol (1996) 20, 115-124. PubMed  Europe PubMed DOI
    48. 1993
  48. Fusek,M., Smith,E.A., Monod,M. and Foundling,S.I.<br>Candida parapsilosis expresses and secretes two aspartic proteinases<br>FEBS Lett (1993) 327, 108-112. PubMed  Europe PubMed DOI
    49. 1988
  49. Hirata,D., Fukui,S. and Yamashita,I.<br>Nucleotide sequence of the secretable acid protease gene PEPI in the yeast Saccharomycopsis fibuligera<br>Agric Biol Chem (1988) 52, 2647-2649.
    50. 1983
  50. [YEAR:16-5-1983]Kolaczkowska,M.K., Wieczorek,M. and Polanowski,A.<br>An aspartic proteinase from Fusarium moniliforme. Purification and general properties<br>Eur J Biochem (16-5-1983) 132, 557-561. PubMed  Europe PubMed  I
  51. Kuczek,M., Nowak,K. and Kolaczkowska,M.<br>Specificity of acid protease from Fusarium moniliforme<br>Acta Biochim Pol (1983) 30, 3-10. PubMed  Europe PubMed

feedback
Page created 8-September-2023

EMBL-EBI logo

© 2025 EBI
Terms of use