Literature for subfamily A1A unassigned peptidases

(Topics flags: I Inhibitor, P Specificity, K Knockout, E Expression, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

2026
1. Chen,W., Defty,N.R., Bartley,K., Nunn,F., Schiavone,A., Bowman,A.S., Hayward,A.D., Burgess,S.T.G., Nisbet,A.J. and Price,D.R.G.
   RNAi-mediated knockdown of the poultry red mite cathepsin D-1 impacts haemoglobin digestion
   Parasit Vectors (2026) PubMed  Europe PubMed DOI
2025
2. Chua,W., Hei,Y., Koh,L.F., Yap,B.L.H., Saw,H.L., Fernandes,T.H.M., da Silva,E.B., Goh,S., Dawson,T.L., Jr., O'Donoghue,A.J., Common,J.E. and Li,H.
   Aspartyl protease MfSAP2 is a key virulence factor in mycelial form of skin fungi Malassezia furfur
   Biochem J (2025) PubMed  Europe PubMed DOI
3. Colombo,M.L., Fernandez,A., Liggieri,C.S., Tornero,P., Bakas,L.S. and Vairo-Cavalli,S.E.
   Aspartic proteases from Silybum marianum: different plant-specific inserts, different destinations
   Planta (2025) 261, 117-117. PubMed  Europe PubMed DOI
4. Xu,X., Liu,Y., Li,X., Zhang,P., Lin,F., Chen,C., Zhang,X., Li,C. and Fu,Q.
   Characterization, expression profiling, and immunological role of Cathepsin D in Sebastes schlegelii during bacterial infection
   Dev Comp Immunol (2025) 167, 105387-105387. PubMed  Europe PubMed DOI
2024
5. Li,W., Li,P., Deng,Y., Zhang,Z., Situ,J., Huang,J., Li,M., Xi,P., Jiang,Z. and Kong,G.
   Litchi aspartic protease LcAP1 enhances plant resistance via suppressing cell death triggered by the pectate lyase PlPeL8 from Peronophythora litchii
   New Phytol (2024) 242, 2682-2701. PubMed  Europe PubMed DOI
6. Lim,S.J., Noor,N.D.M., Sabri,S., Ali,M.S.M., Salleh,A.B. and Oslan,S.N.
   Extracellular BSA-degrading SAPs in the rare pathogen Meyerozyma guilliermondii strain SO as potential virulence factors in candidiasis
   Microb Pathog (2024) 193, 106773-106773. PubMed  Europe PubMed DOI
7. Liu,X.H., Liu,X.T., Wu,Y., Li,S.A., Ren,K.D., Cheng,M., Huang,B., Yang,Y. and Liu,P.P.
   Broadening Horizons: Exploring the Cathepsin Family as Therapeutic Targets for Alzheimer's Disease
   Aging Dis (2024) PubMed  Europe PubMed DOI  V
8. Xue,Y., Yan,Q., Tian,X., Han,D. and Jiang,Z.
   High-level secretory expression and characterization of acid protease in Komagataella phaffii and its application in soybean meal protein degradation
   Int J Biol Macromol (2024) , 137011-137011. PubMed  Europe PubMed DOI
2023
9. Kim,J.S., Lee,K.T. and Bahn,Y.S.
   Secreted aspartyl protease 3 regulated by the Ras/cAMP/PKA pathway promotes the virulence of Candida auris
   Front Cell Infect Microbiol (2023) 13, 1257897-1257897. PubMed  Europe PubMed DOI  PMC  EPMC
2022
10. Qasim,F., Diercks-Horn,S., Gerlach,D., Schneider,A. and Fernandez-Lahore,H.M.
    Production of a novel milk-clotting enzyme from solid-substrate Mucor spp. culture
    J Food Sci (2022) 87, 4348-4362. PubMed  Europe PubMed DOI
11. Qin,S., Zhu,B., Huang,X., Hull,J.J., Chen,L. and Luo,J.
    Functional Role of AsAP in the Reproduction of Adelphocoris suturalis (Hemiptera: Miridae)
    Insects (2022) 13 PubMed  Europe PubMed DOI  PMC  EPMC  K
2021
12. Kang,J.M., Le,H.G., Na,B.K. and Yoo,W.G.
    pH-Dependent Structural Dynamics of Cathepsin D-Family Aspartic Peptidase of Clonorchis sinensis
    Pathogens (2021) 10 PubMed  Europe PubMed DOI  PMC  EPMC
13. Snebergerova,P., Bartosova-Sojkova,P., Jalovecka,M. and Sojka,D.
    Plasmepsin-like Aspartyl Proteases in Babesia
    Pathogens (2021) 10 PubMed  Europe PubMed DOI  PMC  EPMC
2020
14. Ramos,L.S., Oliveira,S.S.C., Braga-Silva,L.A., Branquinha,M.H. and Santos,A.L.S.
    Secreted aspartyl peptidases by the emerging, opportunistic and multidrug-resistant fungal pathogens comprising the Candida haemulonii complex
    Fungal Biol (2020) 124, 700-707. PubMed  Europe PubMed DOI
15. Sukonset,C., Surinlert,P., Thongsum,O., Watthammawut,A., Somrit,M., Nakeim,J., Weerachatyanukul,W. and Asuvapongpatana,S.
    Cathepsin D in prawn reproductive system: its localization and function in actin degradation
    PeerJ (2020) 8, e10218-e10218. PubMed  Europe PubMed DOI  PMC  EPMC
16. Xu,X., Wang,C., Huang,Y., Zhang,S., Yu,H., Meng,J. and Pan,B.
    Evaluation of the vaccine efficacy of three digestive protease antigens from Dermanyssus gallinae using an in vivo rearing system
    Vaccine (2020) 38, 7842-7849. PubMed  Europe PubMed DOI
2018
17. Mancilla-Olea,M.I., Ortega-Lopez,J., Figueroa-Angulo,E.E., Avila-Gonzalez,L., Cardenas-Guerra,R.E., Miranda-Ozuna,J.F.T., Gonzalez-Robles,A., Hernandez-Garcia,M.S., Sanchez-Ayala,L. and Arroyo,R.
    Trichomonas vaginalis cathepsin D-like aspartic proteinase (Tv-CatD) is positively regulated by glucose and degrades human hemoglobin
    Int J Biochem Cell Biol (2018) 97, 1-15. PubMed  Europe PubMed DOI
18. Theron,L.W., Bely,M. and Divol,B.
    Monitoring the impact of an aspartic protease (MpAPr1) on grape proteins and wine properties
    Appl Microbiol Biotechnol (2018) 102, 5173-5183. PubMed  Europe PubMed DOI
2017
19. Theron,L.W., Bely,M. and Divol,B.
    Characterisation of the enzymatic properties of MpAPr1, an aspartic protease secreted by the wine yeast Metschnikowia pulcherrima
    J Sci Food Agric (2017) 97, 3584-3593. PubMed  Europe PubMed DOI
2016
20. Clarke,S.C., Dumesic,P.A., Homer,C.M., O'Donoghue,A.J., La Greca,F., Pallova,L., Majer,P., Madhani,H.D. and Craik,C.S.
    Integrated activity and genetic profiling of secreted peptidases in Cryptococcus neoformans reveals an aspartyl peptidase required for low pH survival and virulence
    PLoS Pathog (2016) 12, e1006051-e1006051. PubMed  Europe PubMed DOI  PMC  EPMC
2013
21. Mandujano-Gonzalez,V., Arana-Cuenca,A., Anducho-Reyes,M.A., Tellez-Jurado,A., Gonzalez-Becerra,A.E. and Mercado-Flores,Y.
    Biochemical study of the extracellular aspartyl protease Eap1 from the phytopathogen fungus Sporisorium reilianum
    Protein Expr Purif (2013) 92, 214-222. PubMed  Europe PubMed DOI
22. Rojo,L., Garcia-Carreno,F. and de Los Angeles Navarrete Del Toro
    Cold-adapted digestive aspartic protease of the clawed lobsters Homarus americanus and Homarus gammarus: biochemical characterization
    Mar Biotechnol (NY) (2013) 15, 87-96. PubMed  Europe PubMed DOI
23. Yu,X.J., Chi,Z., Wang,F., Li,J., Chi,Z.M. and Madzak,C.
    Expression of the acid protease gene from Saccharomycopsis fibuligera in the marine-derived Yarrowia lipolytica for both milk clotting and single cell protein production
    Appl Biochem Biotechnol (2013) 169, 1993-2003. PubMed  Europe PubMed DOI  E
2012
24. Sojka,D., Franta,Z., Frantova,H., Bartosova,P., Horn,M., Vachova,J., O'Donoghue,A.J., Eroy-Reveles,A.A., Craik,C.S., Knudsen,G.M., Caffrey,C.R., McKerrow,J.H., Mares,M. and Kopacek,P.
    Characterization of gut-associated cathepsin D hemoglobinase from tick Ixodes ricinus (IrCD1)
    J Biol Chem (2012) 287, 21152-21163. PubMed  Europe PubMed DOI  P
2011
25. El-Baky,H.A., Linke,D., Nimtz,M. and Berger,R.G.
    PsoP1, a milk-clotting aspartic peptidase from the basidiomycete fungus Piptoporus soloniensis
    J Agric Food Chem (2011) 59, 10311-10316. PubMed  Europe PubMed DOI
26. Rao,S., Mizutani,O., Hirano,T., Masaki,K. and Iefuji,H.
    Purification and characterization of a novel aspartic protease from basidiomycetous yeast Cryptococcus sp. S-2
    J Biosci Bioeng (2011) 112, 441-446. PubMed  Europe PubMed DOI
2010
27. Gomes,F.M., Oliveira,D.M., Motta,L.S., Ramos,I.B., Miranda,K.M. and Machado,E.A.
    Inorganic polyphosphate inhibits an aspartic protease-like activity in the eggs of Rhodnius prolixus (Stahl) and impairs yolk mobilization in vitro
    J Cell Physiol (2010) 222, 606-611. PubMed  Europe PubMed DOI
28. Rojo,L., Muhlia-Almazan,A., Saborowski,R. and Garcia-Carreno,F.
    Aspartic cathepsin D endopeptidase contributes to extracellular digestion in clawed lobsters Homarus americanus and Homarus gammarus
    Mar Biotechnol (NY) (2010) 12, 696-707. PubMed  Europe PubMed DOI
29. ten Have,A., Espino,J.J., Dekkers,E., Van Sluyter,S.C., Brito,N., Kay,J., Gonzalez,C. and van Kan,J.A.
    The Botrytis cinerea aspartic proteinase family
    Fungal Genet Biol (2010) 47, 53-65. PubMed  Europe PubMed DOI
2009
30. Mello,L.V., O'Meara,H., Rigden,D.J. and Paterson,S.
    Identification of novel aspartic proteases from Strongyloides ratti and characterisation of their evolutionary relationships, stage-specific expression and molecular structure
    BMC Genomics (2009) 10, 611-611. PubMed  Europe PubMed DOI
2007
31. Tanji,M., Yakabe,E., Kageyama,T., Yokobori,S., Ichinose,M., Miki,K., Ito,H. and Takahashi,K.
    Purification and characterization of pepsinogens from the gastric mucosa of African coelacanth, Latimeria chalumnae, and properties of the major pepsins
    Comp Biochem Physiol B Biochem Mol Biol (2007) 146, 412-420. PubMed  Europe PubMed DOI
32. Zhou,Q., Fu,X.P., Zhang,L.J., Su,W.J. and Cao,M.J.
    Purification and characterization of sea bream (Sparus latus Houttuyn) pepsinogens and pepsins
    Food Chem (2007) 103, 795-801. DOI
2006
33. Lochnit,G., Grabitzki,J., Henkel,B., Tavernarakis,N. and Geyer,R.
    First identification of a phosphorylcholine-substituted protein from Caenorhabditis elegans: isolation and characterization of the aspartyl protease ASP-6
    Biol Chem (2006) 387, 1487-1493. PubMed  Europe PubMed DOI
34. Navarrete del Toro,M., Garcia-Carreno,F., Lopez,M.D., Celis-Guerrero,L. and Saborowski,R.
    Aspartic proteinases in the digestive tract of marine decapod crustaceans
    J Exp Zoolog Part A Comp Exp Biol (2006) 305, 645-654. PubMed  Europe PubMed DOI
2005
35. [YEAR:14-7-2005]Klemba,M. and Goldberg,D.E.
    Characterization of plasmepsin V, a membrane-bound aspartic protease homolog in the endoplasmic reticulum of Plasmodium falciparum
    Mol Biochem Parasitol (14-7-2005) 143, 183-191. PubMed  Europe PubMed DOI
36. Kotani,N., Kitazume,S., Kamimura,K., Takeo,S., Aigaki,T., Nakato,H. and Hashimoto,Y.
    Characterization of Drosophila aspartic proteases that induce the secretion of a Golgi-resident transferase, heparan sulfate 6-O-sulfotransferase
    J Biochem (2005) 137, 315-322. PubMed  Europe PubMed DOI
37. Mercado-Flores,Y., Trejo-Aguilar,A., Ramirez-Zavala,B., Villa-Tanaca,L. and Hernandez-Rodriguez,C.
    Purification and characterization of an intracellular aspartyl acid proteinase (pumAi) from Ustilago maydis
    Can J Microbiol (2005) 51, 171-175. PubMed  Europe PubMed DOI
2004
38. ten Have,A., Dekkers,E., Kay,J., Phylip,L.H. and van Kan,J.A.
    An aspartic proteinase gene family in the filamentous fungus Botrytis cinerea contains members with novel features
    Microbiology (Reading, Engl.) (2004) 150, 2475-2489. PubMed  Europe PubMed DOI
2003
39. Smith,W.D., Skuce,P.J., Newlands,G.F., Smith,S.K. and Pettit,D.
    Aspartyl proteases from the intestinal brush border of Haemonchus contortus as protective antigens for sheep
    Parasite Immunol (2003) 25, 521-530. PubMed  Europe PubMed DOI
2002
40. [YEAR:31-10-2002]Syntichaki,P., Xu,K., Driscoll,M. and Tavernarakis,N.
    Specific aspartyl and calpain proteases are required for neurodegeneration in C. elegans
    Nature (31-10-2002) 419, 939-944. PubMed  Europe PubMed DOI
2001
41. Nehls,U., Bock,A., Einig,W. and Hampp,R.
    Excretion of two proteases by the ectomycorrhizal fungus Amanita muscaria
    Plant Cell Environ (2001) 24, 741-747.
2000
42. [YEAR:25-8-2000]Tcherepanova,I., Bhattacharyya,L., Rubin,C.S. and Freedman,J.H.
    Aspartic proteases from the nematode Caenorhabditis elegans. Structural organization and developmental and cell-specific expression of asp-1
    J Biol Chem (25-8-2000) 275, 26359-26369. PubMed  Europe PubMed DOI
1999
43. Bang,M.L., Villadsen,I. and Sandal,T.
    Cloning and characterization of an endo-beta-1,3(4)glucanase and an aspartic protease from Phaffia rhodozyma CBS 6938
    Appl Microbiol Biotechnol (1999) 51, 215-222. PubMed  Europe PubMed DOI
44. Geier,G., Banaj,H.J., Heid,H., Bini,L., Pallini,V. and Zwilling,R.
    Aspartyl proteases in Caenorhabditis elegans. Isolation, identification and characterization by a combined use of affinity chromatography, two-dimensional gel electrophoresis, microsequencing and databank analysis
    Eur J Biochem (1999) 264, 872-879. PubMed  Europe PubMed DOI
1998
45. [YEAR:15-8-1998]Gallego,S.G., Slade,R.W. and Brindley,P.J.
    A cDNA encoding a pepsinogen-like, aspartic protease from the human roundworm parasite Strongyloides stercoralis
    Acta Trop (15-8-1998) 71, 17-26. PubMed  Europe PubMed DOI
1997
46. Longbottom,D., Redmond,D.L., Russell,M., Liddell,S., Smith,W.D. and Knox,D.P.
    Molecular cloning and characterisation of a putative aspartate proteinase associated with a gut membrane protein complex from adult Haemonchus contortus
    Mol Biochem Parasitol (1997) 88, 63-72. PubMed  Europe PubMed DOI
1996
47. De Vicente,J.I., De Arriaga,D., Del Valle,P., Soler,J. and Eslava,A.P.
    Purification and characterization of an extracellular aspartate protease from Phycomyces blakesleeanus
    Fungal Genet Biol (1996) 20, 115-124. PubMed  Europe PubMed DOI
1993
48. Fusek,M., Smith,E.A., Monod,M. and Foundling,S.I.
    Candida parapsilosis expresses and secretes two aspartic proteinases
    FEBS Lett (1993) 327, 108-112. PubMed  Europe PubMed DOI
1988
49. Hirata,D., Fukui,S. and Yamashita,I.
    Nucleotide sequence of the secretable acid protease gene PEPI in the yeast Saccharomycopsis fibuligera
    Agric Biol Chem (1988) 52, 2647-2649.
1983
50. [YEAR:16-5-1983]Kolaczkowska,M.K., Wieczorek,M. and Polanowski,A.
    An aspartic proteinase from Fusarium moniliforme. Purification and general properties
    Eur J Biochem (16-5-1983) 132, 557-561. PubMed  Europe PubMed  I
51. Kuczek,M., Nowak,K. and Kolaczkowska,M.
    Specificity of acid protease from Fusarium moniliforme
    Acta Biochim Pol (1983) 30, 3-10. PubMed  Europe PubMed