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Literature for family A1

Family

Summary Holotypes Alignment Tree Genomes Structure Literature H-seq M-seq Architecture

A1A

Summary Holotypes Alignment Tree Genomes Literature

A1B

Summary Holotypes Alignment Tree Genomes Literature

(Topics flags: S Structure, I Inhibitor, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2024
  1. Denesyuk,A.I., Denessiouk,K., Johnson,M.S. and Uversky,V.N.
    Structural Catalytic Core of the Members of the Superfamily of Acid Proteases
    Molecules (2024) 29 PubMed  Europe PubMed DOI  PMC  EPMC
    2. 2021
  2. Bhakat,S.
    Pepsin-like aspartic proteases (PAPs) as model systems for combining biomolecular simulation with biophysical experiments
    RSC Adv (2021) 11, 11026-11047. PubMed  Europe PubMed DOI  PMC  EPMC
  3. Romero,A., Novoa,B. and Figueras,A.
    Genomic and transcriptomic identification of the cathepsin superfamily in the Mediterranean mussel Mytilus galloprovincialis
    Dev Comp Immunol (2021) 127, 104286-104286. PubMed  Europe PubMed DOI
    4. 2019
  4. Cao,S., Guo,M., Wang,C., Xu,W., Shi,T., Tong,G., Zhen,C., Cheng,H., Yang,C., Elsheery,N.I. and Cheng,Y.
    Genome-wide characterization of aspartic protease (AP) gene family in Populus trichocarpa and identification of the potential PtAPs involved in wood formation
    BMC Plant Biol (2019) 19, 276-276. PubMed  Europe PubMed DOI
  5. Soares,A., Ribeiro Carlton,S.M. and Simoes,I.
    Atypical and nucellin-like aspartic proteases: emerging players in plant developmental processes and stress responses
    J Exp Bot (2019) 70, 2059-2076. PubMed  Europe PubMed DOI
    6. 2017
  6. Henriques,B.S., Gomes,B., da Costa,S.G., Moraes,C.D.S., Mesquita,R.D., Dillon,V.M., Garcia,E.S., Azambuja,P., Dillon,R.J. and Genta,F.A.
    Genome wide mapping of peptidases in Rhodnius prolixus: identification of protease gene duplications, horizontally transferred proteases and analysis of peptidase A1 structures, with considerations on their role in the evolution of hematophagy in Triatominae
    Front Physiol (2017) 8, 1051-1051. PubMed  Europe PubMed DOI  PMC  EPMC
  7. Huang,J., Sun,B., Yao,Y. and Liu,J.
    Fast and reliable thermodynamic approach for determining the protonation state of the Asp dyad
    J Chem Inf Model (2017) 57, 2273-2280. PubMed  Europe PubMed DOI
    8. 2016
  8. Cassone,A., Vecchiarelli,A. and Hube,B.
    Aspartyl proteinases of eukaryotic microbial pathogens: from eating to heating
    PLoS Pathog (2016) 12, e1005992-e1005992. PubMed  Europe PubMed DOI
  9. Mahanti,M., Bhakat,S., Nilsson,U.J. and Soderhjelm,P.
    Flap dynamics in aspartic proteases: a computational perspective
    Chem Biol Drug Des (2016) 88, 159-177. PubMed  Europe PubMed DOI
  10. Mandujano-Gonzalez,V., Villa-Tanaca,L., Anducho-Reyes,M.A. and Mercado-Flores,Y.
    Secreted fungal aspartic proteases: a review
    Rev Iberoam Micol (2016) 33, 76-82. PubMed  Europe PubMed DOI
    11. 2015
  11. Tang,L.-J., Li,P.-C., Zhu,L., Wang,R.-F., Chen,X., Li,Z.-Y. and Xu,J.
    Identification, evolutionary and expression profile analysis of the aspartic protease gene superfamily in Arabidopsis thaliana and rice
    Zhiwu Shengli Xuebao Plant Physiol J (2015) 51, 323-336. DOI
    12. 2014
  12. Revuelta,M.V., van Kan,J.A., Kay,J. and ten Have,A.
    Extensive expansion of A1 family aspartic proteinases in fungi revealed by evolutionary analyses of 107 complete eukaryotic proteomes
    Genome Biol Evol (2014) 6, 1480-1494. PubMed  Europe PubMed DOI
    13. 2013
  13. Bairwa,G., Balusu,S. and Kaur,R.
    Aspartyl proteases in human pathogenic fungi: roles in physiology and virulence
    [ISSN:ISBN: 978-162618229-5] (2013) , 159-197.  V
  14. Takahashi,K.
    Structure and function studies on enzymes with a catalytic carboxyl group(s): From ribonuclease T1 to carboxyl peptidases
    Proc Jpn Acad Ser B Phys Biol Sci (2013) 89, 201-225. PubMed  Europe PubMed DOI  V
    15. 2012
  15. Rawlings,N.D. and Barrett,A.J.
    Introduction: aspartic and glutamic peptidases and their clans
    [ISSN:978-0-12-407744-7] (2012) 3, 3-19. DOI
    16. 2011
  16. Dunn,B.M.
    Introduction to the aspartic proteinase family
    Aspartic Acid Proteases as Therapeutic Targets (2011) 45, 1-21. DOI
  17. Ghosh,A.K.
    Aspartic acid proteases as therapeutic targets
    Aspartic Acid Proteases as Therapeutic Targets (2011) 45, 1-615. DOI
  18. Kay,J. and Bur,D.
    Human aspartic proteinases
    Aspartic Acid Proteases as Therapeutic Targets (2011) 45, 43-70. DOI
  19. Tang,J.
    Aspartic proteases: structure, function, and inhibition
    Aspartic Acid Proteases as Therapeutic Targets (2011) 45, 23-41. DOI
    20. 2010
  20. Friedman,R. and Caflisch,A.
    On the orientation of the catalytic dyad in aspartic proteases
    Proteins (2010) 78, 1575-1582. PubMed  Europe PubMed DOI  S
    21. 2009
  21. Chen,J., Ouyang,Y., Wang,L., Xie,W. and Zhang,Q.
    Aspartic proteases gene family in rice: gene structure and expression, predicted protein features and phylogenetic relation
    Gene (2009) 442, 108-118. PubMed  Europe PubMed DOI
  22. Horimoto,Y., Dee,D.R. and Yada,R.Y.
    Multifunctional aspartic peptidase prosegments
    N Biotechnol (2009) 25, 318-324. PubMed  Europe PubMed DOI
    23. 2008
  23. Nguyen,J.T., Hamada,Y., Kimura,T. and Kiso,Y.
    Design of potent aspartic protease inhibitors to treat various diseases
    Arch Pharm (Weinheim) (2008) 341, 523-535. PubMed  Europe PubMed DOI  V  I
    24. 2006
  24. Coates,L., Erskine,P.T., Mall,S., Gill,R., Wood,S.P., Myles,D.A. and Cooper,J.B.
    X-ray, neutron and NMR studies of the catalytic mechanism of aspartic proteinases
    Eur Biophys J (2006) 35, 559-566. PubMed  Europe PubMed DOI  I
  25. [YEAR:5-5-2006]Varon,R., Garcia-Moreno,M., Valera-Ruiperez,D., Garcia-Molina,F., Garcia-Canovas,F., Ladron-de Guevara,R.G., Masia-Perez,J. and Havsteen,B.H.
    Kinetic analysis of a general model of activation of aspartic proteinase zymogens
    J Theor Biol (5-5-2006) 242, 743-754. PubMed  Europe PubMed DOI
    26. 2005
  26. Faro,C. and Gal,S.
    Aspartic proteinase content of the Arabidopsis genome
    Curr Protein Pept Sci (2005) 6, 493-500. PubMed  Europe PubMed
  27. [YEAR:19-8-2005]Russ,A., Pechik,I. and Andreeva,N.
    Database for three dimensional structures of pepsin-like enzymes using the internal coordinate system
    Proteins (19-8-2005) 61, 223-226. PubMed  Europe PubMed DOI
    28. 2004
  28. Beers,E.P., Jones,A.M. and Dickerman,A.W.
    The S8 serine, C1A cysteine and A1 aspartic protease families in Arabidopsis
    Phytochemistry (2004) 65, 43-58. PubMed  Europe PubMed DOI
  29. [YEAR:26-5-2004]Carginale,V., Trinchella,F., Capasso,C., Scudiero,R., Riggio,M. and Parisi,E.
    Adaptive evolution and functional divergence of pepsin gene family
    Gene (26-5-2004) 333, 81-90. PubMed  Europe PubMed DOI
  30. James,M.N.G.
    Catalytic pathway of aspartic peptidases
    [ISSN:0-12-079610-4] (2004) 2, 12-19.  V
    31. 2003
  31. Dash,C., Kulkarni,A., Dunn,B. and Rao,M.
    Aspartic peptidase inhibitors: implications in drug development
    Crit Rev Biochem Mol Biol (2003) 38, 89-119. PubMed  Europe PubMed DOI  I
  32. Hughes,A.L., Green,J.A., Piontkivska,H. and Roberts,R.M.
    Aspartic proteinase phylogeny and the origin of pregnancy-associated glycoproteins
    Mol Biol Evol (2003) 20, 1940-1945. PubMed  Europe PubMed DOI
  33. [YEAR:15-6-2003]Payie,K.G., Tanaka,T., Gal,S. and Yada,R.Y.
    Construction, expression and characterization of a chimaeric mammalian-plant aspartic proteinase
    Biochem J (15-6-2003) 372, 671-678. PubMed  Europe PubMed DOI  PMC  EPMC
    34. 2002
  34. Fruton,J.S.
    A history of pepsin and related enzymes
    Q Rev Biol (2002) 77, 127-147. PubMed  Europe PubMed DOI  V
  35. Kageyama,T.
    Pepsinogens, progastricsins, and prochymosins: structure, function, evolution, and development
    Cell Mol Life Sci (2002) 59, 288-306. PubMed  Europe PubMed DOI
    36. 2001
  36. Andreeva,N.S. and Rumsh,L.D.
    Analysis of crystal structures of aspartic proteinases: on the role of amino acid residues adjacent to the catalytic site of pepsin-like enzymes
    Protein Sci (2001) 10, 2439-2450. PubMed  Europe PubMed DOI  PMC  EPMC
  37. [YEAR:19-10-2001]Brinkworth,R.I., Prociv,P., Loukas,A. and Brindley,P.J.
    Hemoglobin-degrading, aspartic proteases of blood-feeding parasites: substrate specificity revealed by homology models
    J Biol Chem (19-10-2001) 276, 38844-38851. PubMed  Europe PubMed DOI  I
  38. [YEAR:6-11-2001]Coates,L., Erskine,P.T., Wood,S.P., Myles,D.A.A. and Cooper,J.B.
    A neutron Laue diffraction study of endothiapepsin: implications for the aspartic proteinase mechanism
    Biochemistry (6-11-2001) 40, 13149-13157. PubMed  Europe PubMed DOI  I
  39. Jean,L., Long,M.Y., Young,J., Pery,P. and Tomley,F.
    Aspartyl proteinase genes from apicomplexan parasites: evidence for evolution of the gene structure
    Trends Parasitol (2001) 17, 491-498. PubMed  Europe PubMed DOI
  40. Northrop,D.B.
    Follow the protons: a low-barrier hydrogen bond unifies the mechanisms of the aspartic proteases
    Acc Chem Res (2001) 34, 790-797. PubMed  Europe PubMed DOI
    41. 1999
  41. Pechik,I.V., Kashparov,I.V., Novikova,L.A. and Andreeva,N.S.
    Comparison of amino acid sequences and three-dimensional structures of aspartic proteases for use in their protein engineering
    Mol Biol (Mosk) (1999) 33, 434-444.
    42. 1998
  42. Blundell,T.L., Guruprasad,K., Albert,A., Williams,M., Sibanda,B.L. and Dhanaraj,V.
    The aspartic proteinases. An historical overview
    Adv Exp Med Biol (1998) 436, 1-13. PubMed  Europe PubMed
  43. Dunn,B.M., Oda,K., Kay,J., Rao-Naik,C., Lowther,W.T., Beyer,B.M., Scarborough,P.E. and Bukhtiyarova,M.
    Comparison of the specificity of the aspartic proteinases towards internally consistent sets of oligopeptide substrates
    Adv Exp Med Biol (1998) 436, 133-138. PubMed  Europe PubMed
  44. Kashparov,I.V., Popov,M.E. and Popov,E.M.
    Mechanism of action of aspartic proteases
    Adv Exp Med Biol (1998) 436, 115-121. PubMed  Europe PubMed
  45. Khan,A.R. and James,M.N.
    Molecular mechanisms for the conversion of zymogens to active proteolytic enzymes
    Protein Sci (1998) 7, 815-836. PubMed  Europe PubMed DOI  PMC  EPMC
    46. 1997
  46. Yang,J., Teplyakov,A. and Quail,J.W.
    Crystal structure of the aspartic proteinase from Rhizomucor miehei at 2.15 A resolution
    J Mol Biol (1997) 268, 449-459. PubMed  Europe PubMed DOI  S
    47. 1996
  47. Beveridge,A.
    A theoretical study of torsional flexibility in the active site of aspartic proteinases: implications for catalysis
    Proteins (1996) 24, 322-334. PubMed  Europe PubMed DOI
  48. Oldziej,S. and Ciarkowski,J.
    Mechanism of action of aspartic proteinases: application of transition-state analogue theory
    J Comput Aided Mol Des (1996) 10, 583-588. PubMed  Europe PubMed
  49. Park,Y.N., Aikawa,J., Nishiyama,M., Horinouchi,S. and Beppu,T.
    Involvement of a residue at position 75 in the catalytic mechanism of a fungal aspartic proteinase, Rhizomucor pusillus pepsin. Replacement of tyrosine 75 on the flap by asparagine enhances catalytic efficiency
    Protein Eng (1996) 9, 869-875. PubMed  Europe PubMed
  50. Popov,E.M., Kashparov,I.V. and Popov,M.E.
    [Mechanism of aspartic proteinase action. I. Theory and method]
    Bioorg Khim (1996) 22, 323-338. PubMed  Europe PubMed
  51. Tanji,M., Yakabe,E., Kageyama,T. and Takahashi,K.
    The primary structure of the major pepsinogen from the gastric mucosa of tuna stomach
    J Biochem (1996) 120, 647-656. PubMed  Europe PubMed
    52. 1995
  52. Guruprasad,K., Dhanaraj,V., Groves,M. and Blundell,T.L.
    Aspartic proteinases: the structures and functions of a versatile superfamily of enzymes
    Perspect Drug Discov Design (1995) 2, 329-341. DOI  V
  53. Rawlings,N.D. and Barrett,A.J.
    Families of aspartic peptidases, and those of unknown catalytic mechanism
    Methods Enzymol (1995) 248, 105-120. PubMed  Europe PubMed DOI  V
    54. 1994
  54. Lin,X.L., Lin,Y.Z. and Tang,J.
    Relationships of human immunodeficiency virus protease with eukaryotic aspartic proteases
    Methods Enzymol (1994) 241, 195-224. PubMed  Europe PubMed  V
    55. 1993
  55. Abdel-Meguid,S.S.
    Inhibitors of aspartyl proteinases
    Med Res Rev (1993) 13, 731-778. PubMed  Europe PubMed DOI  V  I
    56. 1992
  56. Andreeva,N.S.
    Some aspects of structural studies on aspartic proteinases
    Scand J Clin Lab Invest Suppl (1992) 210, 31-38. PubMed  Europe PubMed  S
  57. Szecsi,P.B.
    The aspartic proteases
    Scand J Clin Lab Invest Suppl (1992) 210, 5-22. PubMed  Europe PubMed
    58. 1990
  58. Davies,D.R.
    The structure and function of the aspartic proteinases
    Annu Rev Biophys Biophys Chem (1990) 19, 189-215. PubMed  Europe PubMed DOI
  59. [YEAR:20-8-1990]Gustchina,A. and Weber,I.T.
    Comparison of inhibitor binding in HIV-1 protease and in non-viral aspartic proteases: the role of the flap
    FEBS Lett (20-8-1990) 269, 269-272. PubMed  Europe PubMed DOI  S
    60. 1989
  60. Miller,M., Jaskolski,M., Rao,J.K., Leis,J. and Wlodawer,A.
    Crystal structure of a retroviral protease proves relationship to aspartic protease family
    Nature (1989) 337, 576-579. PubMed  Europe PubMed DOI  S
    61. 1987
  61. Fruton,J.S.
    Aspartyl proteinases
     (1987) , 1-38.  V
  62. James,M.N.G. and Sielecki,A.R.
    Aspartic proteinases and their catalytic pathway
     (1987) , 414-482.
  63. Tang,J. and Wong,R.N.
    Evolution in the structure and function of aspartic proteases
    J Cell Biochem (1987) 33, 53-63. PubMed  Europe PubMed DOI
    64. 1985
  64. Pearl,L.
    The extended binding cleft of aspartic proteinases and its role in peptide hydrolysis
     (1985) , 189-196.
    65. 1984
  65. [YEAR:23-10-1984]Hofmann,T., Fink,A.L. and Dunn,B.M.
    Cryoenzymology of penicillopepsin; with an appendix: mechanism of action of aspartyl proteinases
    Biochemistry (23-10-1984) 23, 5247-5256. PubMed  Europe PubMed
    66. 1978
  66. Tang,J., James,M.N., Hsu,I.N., Jenkins,J.A. and Blundell,T.L.
    Structural evidence for gene duplication in the evolution of the acid proteases
    Nature (1978) 271, 618-621. PubMed  Europe PubMed
    67. 1977
  67. [YEAR:30-6-1977]James,M.N., Hsu,I.N. and Delbaere,L.T.
    Mechanism of acid protease catalysis based on the crystal structure of penicillopepsin
    Nature (30-6-1977) 267, 808-813. PubMed  Europe PubMed
  68. Subramanian,E., Swan,I.D., Liu,M., Davies,D.R., Jenkins,J.A., Tickle,I.J. and Blundell,T.L.
    Homology among acid proteases: comparison of crystal structures at 3A resolution of acid proteases from Rhizopus chinensis and Endothia parasitica
    Proc Natl Acad Sci U S A (1977) 74, 556-559. PubMed  Europe PubMed  PMC  EPMC
    69. 1976
  69. [YEAR:25-11-1976]Marciniszyn,J., Jr., Hartsuck,J.A. and Tang,J.
    Mode of inhibition of acid proteases by pepstatin
    J Biol Chem (25-11-1976) 251, 7088-7094. PubMed  Europe PubMed  I
  70. Tang,J.
    Pepsin and pepsinogen: models for carboxyl (acid) proteases and their zymogens
    Trends Biochem Sci (1976) 1, 205-208.

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