Literature for A01.A95: plasmepsin-9

(Topics flags: I Inhibitor. To select only the references relevant to a single topic, click the link above. See explanation.)

2025
1. Favuzza,P., Palandri,J., de Lera Ruiz,M., Bailey,W., Boyce,C.W., Danziger,A., Fawaz,M.V., Kelly,M., Murgolo,N., Robbins,J.A., Vavrek,M., Zhao,L., Lei,Z., Guo,Z., Reaksudsan,K., Steel,R.W.J., Hodder,A.N., Ngo,A., Dziekan,J.M., Thompson,J.K., Triglia,T., Birkinshaw,R.W., Penington,J.S., Scally,S.W., Dans,M.G., Coyle,R., Sevilleno,N., Orban,A., Feufack-Donfack,L.B., Popovici,J., Lee,M.C.S., Papenfuss,A., Lowes,K.N., Sleebs,B.E., McCarthy,J.S., McCauley,J.A., Boddey,J.A., Olsen,D.B. and Cowman,A.F.
   MK-7602: a potent multi-stage dual-targeting antimalarial
   EBioMedicine (2025) 123, 106061-106061. PubMed  Europe PubMed DOI  PMC  EPMC  I
2024
2. Lisauskaite,M., Nixon,G.L., Woodley,C.M., Berry,N.G., Coninckx,A., Qie,L.C., Leung,S.C., Taramelli,D., Basilico,N., Parapini,S., Ward,S.A., Vadas,O., Soldati-Favre,D., Hong,W.D. and O'Neill,P.M.
   Design, synthesis and modelling of photoreactive chemical probes for investigating target engagement of plasmepsin IX and X in Plasmodium falciparum
   RSC Chem Biol (2024) 5, 19-29. PubMed  Europe PubMed DOI  PMC  EPMC
2022
3. de Lera Ruiz,M., Favuzza,P., Guo,Z., Zhao,L., Hu,B., Lei,Z., Zhan,D., Murgolo,N., Boyce,C.W., Vavrek,M., Thompson,J., Ngo,A., Jarman,K.E., Robbins,J., Boddey,J., Sleebs,B.E., Lowes,K.N., Cowman,A.F., Olsen,D.B. and McCauley,J.A.
   The Invention of WM382, a Highly Potent PMIX/X Dual Inhibitor toward the Treatment of Malaria
   ACS Med Chem Lett (2022) 13, 1745-1754. PubMed  Europe PubMed DOI  PMC  EPMC  I
2020
4. Burrows,J.N. and Soldati-Favre,D.
   Targeting plasmepsins - an Achilles' Heel of the malaria parasite
   Cell Host Microbe (2020) 27, 496-498. PubMed  Europe PubMed DOI  I
5. Cheuka,P.M., Dziwornu,G., Okombo,J. and Chibale,K.
   Plasmepsin Inhibitors in Antimalarial Drug Discovery: Medicinal Chemistry and Target Validation (2000 to Present)
   J Med Chem (2020) 63, 4445-4467. PubMed  Europe PubMed DOI
6. Favuzza,P., de Lera Ruiz,M., Thompson,J.K., Triglia,T., Ngo,A., Steel,R.W.J., Vavrek,M., Christensen,J., Healer,J., Boyce,C., Guo,Z., Hu,M., Khan,T., Murgolo,N., Zhao,L., Penington,J.S., Reaksudsan,K., Jarman,K., Dietrich,M.H., Richardson,L., Guo,K.Y., Lopaticki,S., Tham,W.H., Rottmann,M., Papenfuss,T., Robbins,J.A., Boddey,J.A., Sleebs,B.E., Sabroux,H.J., McCauley,J.A., Olsen,D.B. and Cowman,A.F.
   Dual plasmepsin-targeting antimalarial agents disrupt multiple stages of the malaria parasite life cycle
   Cell Host Microbe (2020) 27, 642-658. PubMed  Europe PubMed DOI  I
2019
7. Munsamy,G., Agoni,C. and Soliman,M.E.S.
   A dual target of plasmepsin IX and X: unveiling the atomistic superiority of a core chemical scaffold in malaria therapy
   J Cell Biochem (2019) 120, 7876-7887. PubMed  Europe PubMed DOI  I
8. Munsamy,G. and Soliman,M.E.S.
   Unveiling a new era in malaria therapeutics: a tailored molecular approach towards the design of plasmepsin IX inhibitors
   Protein J (2019) 38, 616-627. PubMed  Europe PubMed DOI  I
2018
9. Mukherjee,B., Tessaro,F., Vahokoski,J., Kursula,I., Marq,J.B., Scapozza,L. and Soldati-Favre,D.
   Modeling and resistant alleles explain the selectivity of antimalarial compound 49c towards apicomplexan aspartyl proteases
   EMBO J (2018) 37, e98047-e98047. PubMed  Europe PubMed DOI  I
10. Paul,A.S. and Duraisingh,M.T.
    Targeting Plasmodium proteases to block malaria parasite escape and entry
    Trends Parasitol (2018) 34, 95-97. PubMed  Europe PubMed DOI
2017
11. Dogga,S.K., Mukherjee,B., Jacot,D., Kockmann,T., Molino,L., Hammoudi,P.M., Hartkoorn,R.C., Hehl,A.B. and Soldati-Favre,D.
    A druggable secretory protein maturase of Toxoplasma essential for invasion and egress
    elife (2017) 6 PubMed  Europe PubMed DOI  PMC  EPMC
12. Pino,P., Caldelari,R., Mukherjee,B., Vahokoski,J., Klages,N., Maco,B., Collins,C.R., Blackman,M.J., Kursula,I., Heussler,V., Brochet,M. and Soldati-Favre,D.
    A multistage antimalarial targets the plasmepsins IX and X essential for invasion and egress
    Science (2017) 358, 522-528. PubMed  Europe PubMed DOI  I
13. Zhao,G., Song,X., Kong,X., Zhang,N., Qu,S., Zhu,W., Yang,Y. and Wang,Q.
    Immunization with Toxoplasma gondii aspartic protease 3 increases survival time of infected mice
    Acta Trop (2017) 171, 17-23. PubMed  Europe PubMed DOI