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Literature for peptidase A01.064: candidapepsin SAP6

Summary Alignment Sequences Sequence features Distribution Literature Substrates

(Topics flags: A Assay, P Specificity, I Inhibitor, E Expression. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Zawrotniak,M., Satala,D., Juszczak,M., Bras,G. and Rapala-Kozik,M.<br>Candida albicans aspartyl protease (Sap6) inhibits neutrophil function via a "Trojan horse" mechanism<br>Sci Rep (2025) 15, 6946-6946. PubMed  Europe PubMed DOI  PMC  EPMC
    2. 2022
  2. Veni,A., Lokeswari,T.S., Pavithra,D. and Sugapriya,T.<br>Melianone inhibits Secreted Aspartic Proteases (SAP), a Virulence Factor During Hyphal Formation in Candida albicans<br>Curr Comput Aided Drug Des (2022) 18, 327-336. PubMed  Europe PubMed DOI  I
    3. 2017
  3. Kumar,R., Breindel,C., Saraswat,D., Cullen,P.J. and Edgerton,M.<br>Candida albicans Sap6 amyloid regions function in cellular aggregation and zinc binding, and contribute to zinc acquisition<br>Sci Rep (2017) 7, 2908-2908. PubMed  Europe PubMed DOI  PMC  EPMC
    4. 2016
  4. Winter,M.B., Salcedo,E.C., Lohse,M.B., Hartooni,N., Gulati,M., Sanchez,H., Takagi,J., Hube,B., Andes,D.R., Johnson,A.D., Craik,C.S. and Nobile,C.J.<br>Global identification of biofilm-specific proteolysis in Candida albicans<br>MBio (2016) 7 PubMed  Europe PubMed DOI  PMC  EPMC  A
    5. 2015
  5. Kumar,R., Saraswat,D., Tati,S. and Edgerton,M.<br>Novel aggregation properties of Candida albicans secreted aspartyl proteinase Sap6 mediate virulence in oral candidiasis<br>Infect Immun (2015) 83, 2614-2626. PubMed  Europe PubMed DOI
    6. 2013
  6. Buu,L.M. and Chen,Y.C.<br>Sap6, a secreted aspartyl proteinase, participates in maintenance the cell surface integrity of Candida albicans<br>J Biomed Sci (2013) 20, 101-101. PubMed  Europe PubMed DOI
  7. Pietrella,D., Pandey,N., Gabrielli,E., Pericolini,E., Perito,S., Kasper,L., Bistoni,F., Cassone,A., Hube,B. and Vecchiarelli,A.<br>Secreted aspartic proteases of Candida albicans activate the NLRP3 inflammasome<br>Eur J Immunol (2013) 43, 679-692. PubMed  Europe PubMed DOI
  8. Wu,H., Downs,D., Ghosh,K., Ghosh,A.K., Staib,P., Monod,M. and Tang,J.<br>Candida albicans secreted aspartic proteases 4-6 induce apoptosis of epithelial cells by a novel Trojan horse mechanism<br>FASEB J (2013) 27, 2132-2144. PubMed  Europe PubMed DOI
    9. 2012
  9. Monod,M., Staib,P. and Borelli,C.<br>Candidapepsin<br>[ISSN:978-0-12-407744-7] (2012) 3, 159-166. DOI
    10. 2011
  10. Aoki,W., Kitahara,N., Miura,N., Morisaka,H., Yamamoto,Y., Kuroda,K. and Ueda,M.<br>Comprehensive characterization of secreted aspartic proteases encoded by a virulence gene family in Candida albicans<br>J Biochem (2011) 150, 431-438. PubMed  Europe PubMed DOI  P
    11. 2010
  11. Correia,A., Lermann,U., Teixeira,L., Cerca,F., Botelho,S., Gil Da Costa,R.M., Sampaio,P., Gartner,F., Morschhauser,J., Vilanova,M. and Pais,C.<br>Limited role of secreted aspartyl proteinases Sap1 to Sap6 in Candida albicans virulence and host immune response in murine hematogenously disseminated candidiasis<br>Infect Immun (2010) 78, 4839-4849. PubMed  Europe PubMed DOI
  12. Pietrella,D., Rachini,A., Pandey,N., Schild,L., Netea,M., Bistoni,F., Hube,B. and Vecchiarelli,A.<br>The Inflammatory response induced by aspartic proteases of Candida albicans is independent of proteolytic activity<br>Infect Immun (2010) 78, 4754-4762. PubMed  Europe PubMed DOI
    13. 2009
  13. Parra-Ortega,B., Cruz-Torres,H., Villa-Tanaca,L. and Hernandez-Rodriguez,C.<br>Phylogeny and evolution of the aspartyl protease family from clinically relevant Candida species<br>Mem Inst Oswaldo Cruz (2009) 104, 505-512. PubMed  Europe PubMed
    14. 2008
  14. Lermann,U. and Morschhauser,J.<br>Secreted aspartic proteases are not required for invasion of reconstituted human epithelia by Candida albicans<br>Microbiology (Reading) (2008) 154, 3281-3295. PubMed  Europe PubMed DOI
  15. Naglik,J.R., Moyes,D., Makwana,J., Kanzaria,P., Tsichlaki,E., Weindl,G., Tappuni,A.R., Rodgers,C.A., Woodman,A.J., Challacombe,S.J., Schaller,M. and Hube,B.<br>Quantitative expression of the Candida albicans secreted aspartyl proteinase gene family in human oral and vaginal candidiasis<br>Microbiology (Reading) (2008) 154, 3266-3280. PubMed  Europe PubMed DOI  PMC  EPMC
  16. Odds,F.C.<br>Secreted proteinases and Candida albicans virulence<br>Microbiology (Reading) (2008) 154, 3245-3246. PubMed  Europe PubMed DOI
  17. Staib,P., Lermann,U., Blass-Warmuth,J., Degel,B., Wurzner,R., Monod,M., Schirmeister,T. and Morschhauser,J.<br>Tetracycline-inducible expression of individual secreted aspartic proteases in Candida albicans allows isoenzyme-specific inhibitor screening<br>Antimicrob Agents Chemother (2008) 52, 146-156. PubMed  Europe PubMed DOI  PMC  EPMC
    18. 2002
  18. Felk,A., Kretschmar,M., Albrecht,A., Schaller,M., Beinhauer,S., Nichterlein,T., Sanglard,D., Korting,H.C., Schafer,W. and Hube,B.<br>Candida albicans hyphal formation and the expression of the Efg1-regulated proteinases Sap4 to Sap6 are required for the invasion of parenchymal organs<br>Infect Immun (2002) 70, 3689-3700. PubMed  Europe PubMed DOI  PMC  EPMC
  19. Kretschmar,M., Felk,A., Staib,P., Schaller,M., Hess,D., Callapina,M., Morschhauser,J., Schafer,W., Korting,H.C., Hof,H., Hube,B. and Nichterlein,T.<br>Individual acid aspartic proteinases (Saps) 1-6 of Candida albicans are not essential for invasion and colonization of the gastrointestinal tract in mice<br>Microb Pathog (2002) 32, 61-70. PubMed  Europe PubMed DOI
    20. 2001
  20. De Bernardis,F., Sullivan,P.A. and Cassone,A.<br>Aspartyl proteinases of Candida albicans and their role in pathogenicity<br>Med Mycol (2001) 39, 303-313. PubMed  Europe PubMed
  21. Hube,B. and Naglik,J.<br>Candida albicans proteinases: resolving the mystery of a gene family<br>Microbiology (Reading, Engl.) (2001) 147, 1997-2005. PubMed  Europe PubMed
  22. Schaller,M., Januschke,E., Schackert,C., Woerle,B. and Korting,H.C.<br>Different isoforms of secreted aspartyl proteinases (Sap) are expressed by Candida albicans during oral and cutaneous candidosis in vivo<br>J Med Microbiol (2001) 50, 743-747. PubMed  Europe PubMed
    23. 2000
  23. [YEAR:14-7-2000]Koelsch,G., Tang,J., Loy,J.A., Monod,M., Jackson,K., Foundling,S.I. and Lin,X.L.<br>Enzymic characteristics of secreted aspartic proteases of Candida albicans<br>Biochim Biophys Acta (14-7-2000) 1480, 117-131. PubMed  Europe PubMed DOI
  24. Schaller,M., Schackert,C., Korting,H.C., Januschke,E. and Hube,B.<br>Invasion of Candida albicans correlates with expression of secreted aspartic proteinases during experimental infection of human epidermis<br>J Invest Dermatol (2000) 114, 712-717. PubMed  Europe PubMed DOI
  25. Stehr,F., Felk,A., Kretschmar,M., Schaller,M., Schafer,W. and Hube,B.<br>[Extracellular hydrolytic enzymes and their relevance during Candida albicans infections]<br>Mycoses (2000) 43 Suppl 2, 17-21. PubMed  Europe PubMed
    26. 1999
  26. Kretschmar,M., Hube,B., Bertsch,T., Sanglard,D., Merker,R., Schroder,M., Hof,H. and Nichterlein,T.<br>Germ tubes and proteinase activity contribute to virulence of Candida albicans in murine peritonitis<br>Infect Immun (1999) 67, 6637-6642. PubMed  Europe PubMed  PMC  EPMC
  27. Schaller,M., Korting,H.C., Schafer,W., Bastert,J., Chen,W. and Hube,B.<br>Secreted aspartic proteinase (Sap) activity contributes to tissue damage in a model of human oral candidosis<br>Mol Microbiol (1999) 34, 169-180. PubMed  Europe PubMed DOI
    28. 1998
  28. Borg-von Zepelin,M., Beggah,S., Boggian,K., Sanglard,D. and Monod,M.<br>The expression of the secreted aspartyl proteinases Sap4 to Sap6 from Candida albicans in murine macrophages<br>Mol Microbiol (1998) 28, 543-554. PubMed  Europe PubMed DOI  E
    29. 1997
  29. Sanglard,D., Hube,B., Monod,M., Odds,F.C. and Gow,N.A.<br>A triple deletion of the secreted aspartyl proteinase genes SAP4, SAP5, and SAP6 of Candida albicans causes attenuated virulence<br>Infect Immun (1997) 65, 3539-3546. PubMed  Europe PubMed  PMC  EPMC
    30. 1994
  30. Hube,B., Monod,M., Schofield,D.A., Brown,A.J. and Gow,N.A.<br>Expression of seven members of the gene family encoding secretory aspartyl proteinases in Candida albicans<br>Mol Microbiol (1994) 14, 87-99. PubMed  Europe PubMed DOI
  31. Monod,M., Togni,G., Hube,B. and Sanglard,D.<br>Multiplicity of genes encoding secreted aspartic proteinases in Candida species<br>Mol Microbiol (1994) 13, 357-368. PubMed  Europe PubMed DOI

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