Literature for peptidase A01.060: candidapepsin SAP2

(Topics flags: S Structure, P Specificity, I Inhibitor, E Expression. To select only the references relevant to a single topic, click the link above. See explanation.)

2020
1. Li,C., Liu,Y., Wu,S., Han,G., Tu,J., Dong,G., Liu,N. and Sheng,C.
   Targeting fungal virulence factor by small molecules: Structure-based discovery of novel secreted aspartic protease 2 (SAP2) inhibitors
   Eur J Med Chem201, 112515-112515. PubMed  Europe PubMed DOI  I
2018
2. Dong,G., Liu,Y., Wu,Y., Tu,J., Chen,S., Liu,N. and Sheng,C.
   Novel non-peptidic small molecule inhibitors of secreted aspartic protease 2 (SAP2) for the treatment of resistant fungal infections
   Chem Commun (Camb)54, 13535-13538. PubMed  Europe PubMed DOI  I
2016
3. Bochenska,O., Rapala-Kozik,M., Wolak,N., Aoki,W., Ueda,M. and Kozik,A.
   The action of ten secreted aspartic proteases of pathogenic yeast Candida albicans on major human salivary antimicrobial peptide, histatin 5
   Acta Biochim Pol63, 403-410. PubMed  Europe PubMed DOI
4. Gogol,M., Ostrowska,D., Klaga,K., Bochenska,O., Wolak,N., Aoki,W., Ueda,M., Kozik,A. and Rapala-Kozik,M.
   Inactivation of alpha1-proteinase inhibitor by Candida albicans aspartic proteases favors the epithelial and endothelial cell colonization in the presence of neutrophil extracellular traps
   Acta Biochim Pol63, 167-175. PubMed  Europe PubMed DOI
2015
5. Pericolini,E., Gabrielli,E., Amacker,M., Kasper,L., Roselletti,E., Luciano,E., Sabbatini,S., Kaeser,M., Moser,C., Hube,B., Vecchiarelli,A. and Cassone,A.
   Secretory aspartyl proteinases cause vaginitis and can mediate vaginitis caused by Candida albicans in mice
   MBio6, e00724-e00724. PubMed  Europe PubMed DOI
6. Svoboda,E., Schneider,A.E., Sandor,N., Lermann,U., Staib,P., Kremlitzka,M., Bajtay,Z., Barz,D., Erdei,A. and Jozsi,M.
   Secreted aspartic protease 2 of Candida albicans inactivates factor H and the macrophage factor H-receptors CR3 (CD11b/CD18) and CR4 (CD11c/CD18)
   Immunol Lett168, 13-21. PubMed  Europe PubMed DOI
2014
7. Calugi,C., Guarna,A. and Trabocchi,A.
   Identification of constrained peptidomimetic chemotypes as HIV protease inhibitors
   Eur J Med Chem84, 444-453. PubMed  Europe PubMed DOI  I
8. Jebali,A., Hajjar,F.H., Hekmatimoghaddam,S., Kazemi,B., De La Fuente,J.M. and Rashidi,M.
   Triangular gold nanoparticles conjugated with peptide ligands: a new class of inhibitor for Candida albicans secreted aspartyl proteinase
   Biochem Pharmacol90, 349-355. PubMed  Europe PubMed DOI  I
2013
9. Cadicamo,C.D., Mortier,J., Wolber,G., Hell,M., Heinrich,I.E., Michel,D., Semlin,L., Berger,U., Korting,H.C., Holtje,H.D., Koksch,B. and Borelli,C.
   Design, synthesis, inhibition studies, and molecular modeling of pepstatin analogues addressing different secreted aspartic proteinases of Candida albicans
   Biochem Pharmacol85, 881-887. PubMed  Europe PubMed DOI  I
10. Calugi,C., Guarna,A. and Trabocchi,A.
    Insight into the structural similarity between HIV protease and secreted aspartic protease-2 and binding mode analysis of HIV-Candida albicans inhibitors
    J Enzyme Inhib Med Chem28, 936-943. PubMed  Europe PubMed DOI
11. Kutyreva,M.P., Ulakhovich,N.A., Gataulina,A.R., Mukhametzyanova,A.R. and Khaldeeva,E.V.
    Interaction of secreted aspartic proteinase Candida albicans with ZnCl2: complex formation and catalytic activity
    World Appl Sci J27, 1225-1229. DOI
12. Pietrella,D., Pandey,N., Gabrielli,E., Pericolini,E., Perito,S., Kasper,L., Bistoni,F., Cassone,A., Hube,B. and Vecchiarelli,A.
    Secreted aspartic proteases of Candida albicans activate the NLRP3 inflammasome
    Eur J Immunol43, 679-692. PubMed  Europe PubMed DOI
2012
13. Bras,G., Bochenska,O., Rapala-Kozik,M., Guevara-Lora,I., Faussner,A. and Kozik,A.
    Extracellular aspartic protease SAP2 of Candida albicans yeast cleaves human kininogens and releases proinflammatory peptides, Met-Lys-bradykinin and des-Arg(9)-Met-Lys-bradykinin
    Biol Chem393, 829-839. PubMed  Europe PubMed DOI
14. Calugi,C., Trabocchi,A., De Bernardis,F., Arancia,S., Navarra,P., Cauda,R., Cassone,A. and Guarna,A.
    Bicyclic peptidomimetics targeting secreted aspartic protease 2 (SAP2) from Candida albicans reveal a constrained inhibitory chemotype
    Bioorg Med Chem20, 7206-7213. PubMed  Europe PubMed DOI  I
15. De Bernardis,F., Amacker,M., Arancia,S., Sandini,S., Gremion,C., Zurbriggen,R., Moser,C. and Cassone,A.
    A virosomal vaccine against candidal vaginitis: immunogenicity, efficacy and safety profile in animal models
    Vaccine30, 4490-4498. PubMed  Europe PubMed DOI
16. Monod,M., Staib,P. and Borelli,C.
    Candidapepsin
    [ISSN:978-0-12-407744-7]3, 159-166. DOI
2011
17. Aoki,W., Kitahara,N., Miura,N., Morisaka,H., Yamamoto,Y., Kuroda,K. and Ueda,M.
    Comprehensive characterization of secreted aspartic proteases encoded by a virulence gene family in Candida albicans
    J Biochem150, 431-438. PubMed  Europe PubMed DOI  P
18. Buchold,C., Hemberger,Y., Heindl,C., Welker,A., Degel,B., Pfeuffer,T., Staib,P., Schneider,S., Rosenthal,P.J., Gut,J., Morschhauser,J., Bringmann,G. and Schirmeister,T.
    New cis-configured aziridine-2-carboxylates as aspartic acid protease inhibitors
    ChemMedChem6, 141-152. PubMed  Europe PubMed DOI  I
19. Dunkel,N. and Morschhauser,J.
    Loss of heterozygosity at an unlinked genomic locus is responsible for the phenotype of a Candida albicans sap4Delta sap5Delta sap6Delta mutant
    Eukaryot Cell10, 54-62. PubMed  Europe PubMed DOI
20. Elaheh,M., Hossein,Y.M., Majid,S. and Mohammad,Z.H.
    The effect of Candida albicans secreted aspartic proteinase 2 expressed in Pichia pastoris on macrophage ingestion
    Aust J Basic Appl Sci5, 2939-2946.  E
21. Sandini,S., La Valle,R., Deaglio,S., Malavasi,F., Cassone,A. and De Bernardis,F.
    A highly immunogenic recombinant and truncated protein of the secreted aspartic proteases family (rSap2t) of Candida albicans as a mucosal anticandidal vaccine
    FEMS Immunol Med Microbiol62, 215-224. PubMed  Europe PubMed DOI
2010
22. Correia,A., Lermann,U., Teixeira,L., Cerca,F., Botelho,S., Gil Da Costa,R.M., Sampaio,P., Gartner,F., Morschhauser,J., Vilanova,M. and Pais,C.
    Limited role of secreted aspartyl proteinases Sap1 to Sap6 in Candida albicans virulence and host immune response in murine hematogenously disseminated candidiasis
    Infect Immun78, 4839-4849. PubMed  Europe PubMed DOI
23. Pietrella,D., Rachini,A., Pandey,N., Schild,L., Netea,M., Bistoni,F., Hube,B. and Vecchiarelli,A.
    The Inflammatory response induced by aspartic proteases of Candida albicans is independent of proteolytic activity
    Infect Immun78, 4754-4762. PubMed  Europe PubMed DOI
24. Trabocchi,A., Mannino,C., Machetti,F., De Bernardis,F., Arancia,S., Cauda,R., Cassone,A. and Guarna,A.
    Identification of inhibitors of drug-resistant Candida albicans strains from a library of bicyclic peptidomimetic compounds
    J Med Chem53, 2502-2509. PubMed  Europe PubMed DOI  I
2009
25. Gropp,K., Schild,L., Schindler,S., Hube,B., Zipfel,P.F. and Skerka,C.
    The yeast Candida albicans evades human complement attack by secretion of aspartic proteases
    Mol Immunol47, 465-475. PubMed  Europe PubMed DOI
26. Parra-Ortega,B., Cruz-Torres,H., Villa-Tanaca,L. and Hernandez-Rodriguez,C.
    Phylogeny and evolution of the aspartyl protease family from clinically relevant Candida species
    Mem Inst Oswaldo Cruz104, 505-512. PubMed  Europe PubMed
2008
27. Degel,B., Staib,P., Rohrer,S., Scheiber,J., Martina,E., Buchold,C., Baumann,K., Morschhauser,J. and Schirmeister,T.
    Cis-Configured aziridines are new pseudo-irreversible dual-mode inhibitors of Candida albicans secreted aspartic protease 2
    ChemMedChem3, 302-315. PubMed  Europe PubMed DOI  I
28. Lermann,U. and Morschhauser,J.
    Secreted aspartic proteases are not required for invasion of reconstituted human epithelia by Candida albicans
    Microbiology (Reading)154, 3281-3295. PubMed  Europe PubMed DOI
29. Naglik,J.R., Moyes,D., Makwana,J., Kanzaria,P., Tsichlaki,E., Weindl,G., Tappuni,A.R., Rodgers,C.A., Woodman,A.J., Challacombe,S.J., Schaller,M. and Hube,B.
    Quantitative expression of the Candida albicans secreted aspartyl proteinase gene family in human oral and vaginal candidiasis
    Microbiology (Reading)154, 3266-3280. PubMed  Europe PubMed DOI
30. Odds,F.C.
    Secreted proteinases and Candida albicans virulence
    Microbiology (Reading)154, 3245-3246. PubMed  Europe PubMed DOI
31. Staib,P., Lermann,U., Blass-Warmuth,J., Degel,B., Wurzner,R., Monod,M., Schirmeister,T. and Morschhauser,J.
    Tetracycline-inducible expression of individual secreted aspartic proteases in Candida albicans allows isoenzyme-specific inhibitor screening
    Antimicrob Agents Chemother52, 146-156. PubMed  Europe PubMed DOI
32. Tongchusak,S., Leelayuwat,C., Brusic,V. and Chaiyaroj,S.C.
    In silico prediction and immunological validation of common HLA-DRB1-restricted T cell epitopes of Candida albicans secretory aspartyl proteinase 2
    Microbiol Immunol52, 231-242. PubMed  Europe PubMed DOI
2005
33. Copping,V.M., Barelle,C.J., Hube,B., Gow,N.A., Brown,A.J. and Odds,F.C.
    Exposure of Candida albicans to antifungal agents affects expression of SAP2 and SAP9 secreted proteinase genes
    J Antimicrob Chemother55, 645-654. PubMed  Europe PubMed DOI
2004
34. Vilanova,M., Teixeira,L., Caramalho,I., Torrado,E., Marques,A., Madureira,P., Ribeiro,A., Ferreira,P., Gama,M. and Demengeot,J.
    Protection against systemic candidiasis in mice immunized with secreted aspartic proteinase 2
    Immunology111, 334-342. PubMed  Europe PubMed DOI
2003
35. [YEAR:21-3-2003]Backman,D. and Danielson,U.H.
    Kinetic and mechanistic analysis of the association and dissociation of inhibitors interacting with secreted aspartic acid proteases 1 and 2 from Candida albicans
    Biochim Biophys Acta1646, 184-195. PubMed  Europe PubMed DOI  I
36. Schaller,M., Bein,M., Korting,H.C., Baur,S., Hamm,G., Monod,M., Beinhauer,S. and Hube,B.
    The secreted aspartyl proteinases Sap1 and Sap2 cause tissue damage in an in vitro model of vaginal candidiasis based on reconstituted human vaginal epithelium
    Infect Immun71, 3227-3234. PubMed  Europe PubMed DOI  I
37. [YEAR:3-11-2003]Tossi,A., Benedetti,F., Norbedo,S., Skrbec,D., Berti,F. and Romeo,D.
    Small hydroxyethylene-based peptidomimetics inhibiting both HIV-1 and C. albicans aspartic proteases
    Bioorg Med Chem11, 4719-4727. PubMed  Europe PubMed DOI
2002
38. Felk,A., Kretschmar,M., Albrecht,A., Schaller,M., Beinhauer,S., Nichterlein,T., Sanglard,D., Korting,H.C., Schafer,W. and Hube,B.
    Candida albicans hyphal formation and the expression of the Efg1-regulated proteinases Sap4 to Sap6 are required for the invasion of parenchymal organs
    Infect Immun70, 3689-3700. PubMed  Europe PubMed DOI
39. Kretschmar,M., Felk,A., Staib,P., Schaller,M., Hess,D., Callapina,M., Morschhauser,J., Schafer,W., Korting,H.C., Hof,H., Hube,B. and Nichterlein,T.
    Individual acid aspartic proteinases (Saps) 1-6 of Candida albicans are not essential for invasion and colonization of the gastrointestinal tract in mice
    Microb Pathog32, 61-70. PubMed  Europe PubMed DOI
40. Pranav Kumar,S.K. and Kulkarni,V.M.
    Insights into the selective inhibition of Candida albicans secreted aspartyl protease: a docking analysis study
    Bioorg Med Chem10, 1153-1170. PubMed  Europe PubMed DOI  I
41. [YEAR:11-10-2002]Skrbec,D. and Romeo,D.
    Inhibition of Candida albicans secreted aspartic protease by a novel series of peptidomimetics, also active on the HIV-1 protease
    Biochem Biophys Res Commun297, 1350-1353. PubMed  Europe PubMed DOI
2001
42. De Bernardis,F., Sullivan,P.A. and Cassone,A.
    Aspartyl proteinases of Candida albicans and their role in pathogenicity
    Med Mycol39, 303-313. PubMed  Europe PubMed
43. Pichova,I., Pavlickova,L., Dostal,J., Dolejsi,E., Hruskova-Heidingsfeldova,O., Weber,J., Ruml,T. and Soucek,M.
    Secreted aspartic proteases of Candida albicans, Candida tropicalis, Candida parapsilosis and Candida lusitaniae. Inhibition with peptidomimetic inhibitors
    Eur J Biochem268, 2669-2677. PubMed  Europe PubMed DOI  I
44. Schaller,M., Januschke,E., Schackert,C., Woerle,B. and Korting,H.C.
    Different isoforms of secreted aspartyl proteinases (Sap) are expressed by Candida albicans during oral and cutaneous candidosis in vivo
    J Med Microbiol50, 743-747. PubMed  Europe PubMed
2000
45. [YEAR:14-7-2000]Koelsch,G., Tang,J., Loy,J.A., Monod,M., Jackson,K., Foundling,S.I. and Lin,X.L.
    Enzymic characteristics of secreted aspartic proteases of Candida albicans
    Biochim Biophys Acta1480, 117-131. PubMed  Europe PubMed DOI
46. Schaller,M., Schackert,C., Korting,H.C., Januschke,E. and Hube,B.
    Invasion of Candida albicans correlates with expression of secreted aspartic proteinases during experimental infection of human epidermis
    J Invest Dermatol114, 712-717. PubMed  Europe PubMed DOI
47. Stehr,F., Felk,A., Kretschmar,M., Schaller,M., Schafer,W. and Hube,B.
    [Extracellular hydrolytic enzymes and their relevance during Candida albicans infections]
    Mycoses43 Suppl 2, 17-21. PubMed  Europe PubMed
1999
48. Borg-von Zepelin,M., Meyer,I., Thomssen,R., Wurzner,R., Sanglard,D., Telenti,A. and Monod,M.
    HIV-protease inhibitors reduce cell adherence of Candida albicans strains by inhibition of yeast secreted aspartic proteases
    J Invest Dermatol113, 747-751. PubMed  Europe PubMed DOI  I
49. De Bernardis,F., Arancia,S., Morelli,L., Hube,B., Sanglard,D., Schafer,W. and Cassone,A.
    Evidence that members of the secretory aspartyl proteinase gene family, in particular SAP2, are virulence factors for Candida vaginitis
    J Infect Dis179, 201-208. PubMed  Europe PubMed DOI
50. Kretschmar,M., Hube,B., Bertsch,T., Sanglard,D., Merker,R., Schroder,M., Hof,H. and Nichterlein,T.
    Germ tubes and proteinase activity contribute to virulence of Candida albicans in murine peritonitis
    Infect Immun67, 6637-6642. PubMed  Europe PubMed
51. Monod,M., Borg-von Zepelin,M., Telenti,A. and Sanglard,D.
    The inhibition of Candida-albicans-secreted aspartic proteases by three different HIV protease inhibitors
    Dermatology198, 412-414. PubMed  Europe PubMed  I
52. Schaller,M., Korting,H.C., Schafer,W., Bastert,J., Chen,W. and Hube,B.
    Secreted aspartic proteinase (Sap) activity contributes to tissue damage in a model of human oral candidosis
    Mol Microbiol34, 169-180. PubMed  Europe PubMed DOI
53. Staib,P., Kretschmar,M., Nichterlein,T., Kohler,G., Michel,S., Hof,H., Hacker,J. and Morschhauser,J.
    Host-induced, stage-specific virulence gene activation in Candida albicans during infection
    Mol Microbiol32, 533-546. PubMed  Europe PubMed DOI
1998
54. Abad-Zapatero,C., Goldman,R., Muchmore,S.W., Hutchins,C., Oie,T., Stewart,K., Cutfield,S.M., Cutfield,J.F., Foundling,S.I. and Ray,T.L.
    Structure of secreted aspartic proteinases from Candida. Implications for the design of antifungal agents
    Adv Exp Med Biol436, 297-313. PubMed  Europe PubMed  S  I
55. Dubois,N., Colina,A.R., Aumont,F., Belhumeur,P. and de Repentigny,L.
    Overexpression of Candida albicans secretory aspartyl proteinase 2 and its expression in Saccharomyces cerevisiae do not augment virulence in mice
    Microbiology (Reading, Engl )144, 2299-2310. PubMed  Europe PubMed
1997
56. Hube,B., Sanglard,D., Odds,F.C., Hess,D., Monod,M., Schafer,W., Brown,A.J. and Gow,N.A.
    Disruption of each of the secreted aspartyl proteinase genes SAP1, SAP2, and SAP3 of Candida albicans attenuates virulence
    Infect Immun65, 3529-3538. PubMed  Europe PubMed
57. [YEAR:14-11-1997]Newport,G. and Agabian,N.
    KEX2 influences Candida albicans proteinase secretion and hyphal formation
    J Biol Chem272, 28954-28961. PubMed  Europe PubMed DOI
58. Smolenski,G., Sullivan,P.A., Cutfield,S.M. and Cutfield,J.F.
    Analysis of secreted aspartic proteinases from Candida albicans: purification and characterization of individual Sap1, Sap2 and Sap3 isoenzymes
    Microbiology (Reading, Engl )143, 349-356. PubMed  Europe PubMed
1996
59. Abad-Zapatero,C., Goldman,R., Muchmore,S.W., Hutchins,C., Stewart,K., Navaza,J., Payne,C.D. and Ray,T.L.
    Structure of a secreted aspartic protease from C. albicans complexed with a potent inhibitor: implications for the design of antifungal agents
    Protein Sci5, 640-652. PubMed  Europe PubMed DOI  S
60. Colina,A.R., Aumont,F., Deslauriers,N., Belhumeur,P. and de Repentigny,L.
    Evidence for degradation of gastrointestinal mucin by Candida albicans secretory aspartyl proteinase
    Infect Immun64, 4514-4519. PubMed  Europe PubMed
61. Hube,B.
    Candida albicans secreted aspartyl proteinases
    Curr Top Med Mycol7, 55-69. PubMed  Europe PubMed
1995
62. Cutfield,S.M., Dodson,E.J., Anderson,B.F., Moody,P.C., Marshall,C.J., Sullivan,P.A. and Cutfield,J.F.
    The crystal structure of a major secreted aspartic proteinase from Candida albicans in complexes with two inhibitors
    Structure3, 1261-1271. PubMed  Europe PubMed  S  I
1994
63. Hube,B., Monod,M., Schofield,D.A., Brown,A.J. and Gow,N.A.
    Expression of seven members of the gene family encoding secretory aspartyl proteinases in Candida albicans
    Mol Microbiol14, 87-99. PubMed  Europe PubMed DOI
64. Monod,M., Togni,G., Hube,B. and Sanglard,D.
    Multiplicity of genes encoding secreted aspartic proteinases in Candida species
    Mol Microbiol13, 357-368. PubMed  Europe PubMed DOI
1993
65. White,T.C., Miyasaki,S.H. and Agabian,N.
    Three distinct secreted aspartyl proteinases in Candida albicans
    J Bacteriol175, 6126-6133. PubMed  Europe PubMed