Literature for peptidase A01.021: plasmepsin (Plasmodium sp.)

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

(Topics flags: S Structure, I Inhibitor, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2020
  1. Cheuka,P.M., Dziwornu,G., Okombo,J. and Chibale,K.
    Plasmepsin Inhibitors in Antimalarial Drug Discovery: Medicinal Chemistry and Target Validation (2000 to Present)
    J Med Chem63, 4445-4467. PubMed  Europe PubMed DOI
  2. 2019
  3. Bobrovs,R., Jaudzems,K. and Jirgensons,A.
    Exploiting structural dynamics to design open-flap inhibitors of malarial aspartic proteases
    J Med Chem62, 8931-8950. PubMed  Europe PubMed DOI  I
  4. 2014
  5. Kumar,S., Briguglio,J.S. and Turkewitz,A.P.
    An aspartyl cathepsin, CTH3, is essential for proprotein processing during secretory granule maturation in Tetrahymena thermophila
    Mol Biol Cell25, 2444-2460. PubMed  Europe PubMed DOI
  6. 2012
  7. Berry,C. and Goldberg,D.E.
    Food vacuole plasmepsins
    [ISSN:978-0-12-407744-7]3, 98-103. DOI
  8. Meyers,M.J. and Goldberg,D.E.
    Recent advances in plasmepsin medicinal chemistry and implications for future antimalarial drug discovery efforts
    Curr Top Med Chem12, 445-455. PubMed  Europe PubMed DOI  I
  9. 2006
  10. [YEAR:2-12-2006]Martins,T.M., Domingos,A., Berry,C. and Wyatt,D.M.
    The activity and inhibition of the food vacuole plasmepsin from the rodent malaria parasite Plasmodium chabaudi
    Acta Trop97, 212-218. PubMed  Europe PubMed DOI
  11. 2005
  12. Sharma,A., Eapen,A. and Subbarao,S.K.
    Purification and characterization of a hemoglobin degrading aspartic protease from the malarial parasite Plasmodium vivax
    J Biochem138, 71-78. PubMed  Europe PubMed DOI
  13. 2004
  14. Berry,C. and Goldberg,D.E.
    Plasmepsins
    [ISSN:0-12-079610-4]2, 70-73.  V
  15. Na,B.K., Lee,E.G., Lee,H.W., Cho,S.H., Bae,Y.A., Kong,Y., Lee,J.K. and Kim,T.S.
    Aspartic proteases of Plasmodium vivax are highly conserved in wild isolates
    Korean J Parasitol42, 61-66. PubMed  Europe PubMed
  16. 2003
  17. [YEAR:6-6-2003]Bernstein,N.K., Cherney,M.M., Yowell,C.A., Dame,J.B. and James,M.N.
    Structural insights into the activation of P. vivax plasmepsin
    J Mol Biol329, 505-524. PubMed  Europe PubMed DOI  S
  18. Martins,T.M., Novo,C., do Rosario,V.E. and Domingos,A.
    Aspartic proteases from Plasmodium chabaudi: a rodent model for human malaria
    Acta Trop89, 1-12. PubMed  Europe PubMed DOI
  19. 2001
  20. [YEAR:19-10-2001]Brinkworth,R.I., Prociv,P., Loukas,A. and Brindley,P.J.
    Hemoglobin-degrading, aspartic proteases of blood-feeding parasites: substrate specificity revealed by homology models
    J Biol Chem276, 38844-38851. PubMed  Europe PubMed DOI  I
  21. Coombs,G.H., Goldberg,D.E., Klemba,M., Berry,C., Kay,J. and Mottram,J.C.
    Aspartic proteases of Plasmodium falciparum and other parasitic protozoa as drug targets
    Trends Parasitol17, 532-537. PubMed  Europe PubMed DOI
  22. Jiang,S.P., Prigge,S.T., Wei,L., Gao,Y.E., Hudson,T.H., Gerena,L., Dame,J.B. and Kyle,D.E.
    New class of small nonpeptidyl compounds blocks Plasmodium falciparum development in vitro by inhibiting plasmepsins
    Antimicrobial Agents Chemother45, 2577-2584. PubMed  Europe PubMed DOI
  23. 1999
  24. [YEAR:10-12-1999]Humphreys,M.J., Moon,R.P., Klinder,A., Fowler,S.D., Rupp,K., Bur,D., Ridley,R.G. and Berry,C.
    The aspartic proteinase from the rodent parasite Plasmodium berghei as a potential model for plasmepsins from the human malaria parasite, Plasmodium falciparum
    FEBS Lett463, 43-48. PubMed  Europe PubMed DOI
  25. 1997
  26. Westling,J., Yowell,C.A., Majer,P., Erickson,J.W., Dame,J.B. and Dunn,B.M.
    Plasmodium falciparum, P. vivax, and P. malariae: a comparison of the active site properties of plasmepsins cloned and expressed from three different species of the malaria parasite
    Exp Parasitol87, 185-193. PubMed  Europe PubMed DOI