Literature for peptidase A01.007: renin

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

(Topics flags: A Assay, S Structure, T Target, P Specificity, K Knockout, E Expression, V Review, M Mutation, I Inhibitor, L Localization. To select only the references relevant to a single topic, click the link above. See explanation.)

2026

Wu,L., Zhang,B., Zhang,Y., Yang,S., Shi,C., Wang,W., Fang,Z., Zhang,L. and Qin,X. Evaluation of the MAGLUMI non-competitive angiotensin I chemiluminescence immunoassay for measuring renin activity in human plasma Clin Chem Lab Med (2026) PubMed Europe PubMed DOI

2025

Adhikari,A., Sharma,C., Lhamu Sherpa,M., Karaunakran,G., Dhakal,M. and Sharma,A. Impact of Renin-Angiotensin-Aldosterone System (RAAS) Gene Polymorphism in Essential Hypertension and Antihypertensive Drug Therapy: A Review Int J Hypertens (2025) 2025, 5530265-5530265. PubMed Europe PubMed DOI PMC EPMC V
Akkan,C., Das,M., Bardakci,O., Sehitoglu,M.H., Akdur,G., Akman,C., Akdur,O. and Beyazit,Y. A prediction model for lung involvement using circulating angiotensin converting enzyme-2 and renin levels in COVID-19 patients J Infect Dev Ctries (2025) 19, 1432-1442. PubMed Europe PubMed DOI
Hill,R.Z., Nelson,J.W., Gyarmati,G., Medrano,S., Shirvan,S., McCormick,J.A., Burquez,S., Ahmed,J., Eng,D.G., Wysocki,J., Dubin,A.E., Servin-Vences,M.R., Lakshmanan,A., Gomez,R.A., Sequeira-Lopez,M.L.S., Shankland,S.J., Batlle,D., Miner,J.H., Peti-Peterdi,J. and Patapoutian,A. Renal PIEZO2 is an essential regulator of renin Cell (2025) PubMed Europe PubMed DOI PMC EPMC
Nunez,F.F., Siqueiros-Marquez,L., Adan-Castro,E., Zamora,M., Robles,J.P., Ruiz-Herrera,X., Bertsch,T., Triebel,J., Martinez de la Escalera,G. and Clapp,C. Vasoinhibin is generated by the Renin-Angiotensin System Endocrinology (2025) PubMed Europe PubMed DOI
Sealey,J.E. and Blumenfeld,J.D. Maintenance of blood pressure by reactive increases in plasma renin activity during salt depletion and renin-angiotensin system inhibition J Hypertens (2025) 43, 1457-1457. PubMed Europe PubMed DOI PMC EPMC
Trerattanavong,K. and Chen,J. Biochemistry, Renin (2025) PubMed Europe PubMed
Valiente,P.A., Guerra,Y., Wolf,M.G., Pascual,I., Rudino-Pinera,E., Florent,I., Pons,T. and Groenhof,G. Discovery of a Noncompetitive Open-Flap Selective Inhibitor of Plasmepsin II with Antiplasmodial Activity J Chem Inf Model (2025) PubMed Europe PubMed DOI I
Wieruszewski,P.M. Renin Is an Important Prognostic and Predictive Biomarker in Cardiac Surgery-associated Acute Kidney Injury J Cardiothorac Vasc Anesth (2025) PubMed Europe PubMed DOI

2024

Chakradhar,A., Baron,R.M., Vera,M.P., Devarajan,P., Chawla,L. and Hou,P.C. Plasma renin as a novel prognostic biomarker of sepsis-associated acute respiratory distress syndrome Sci Rep (2024) 14, 6667-6667. PubMed Europe PubMed DOI PMC EPMC V
Kotani,Y., Belletti,A., Maiucci,G., Lodovici,M., Fresilli,S., Landoni,G., Bellomo,R. and Zarbock,A. Renin as a Prognostic Marker in Intensive Care and Perioperative Settings: A Scoping Review Anesth Analg (2024) 138, 929-936. PubMed Europe PubMed DOI V
Kotani,Y., Chappell,M., Landoni,G., Zarbock,A., Bellomo,R. and Khanna,A.K. Renin in critically ill patients Ann Intensive Care (2024) 14, 79-79. PubMed Europe PubMed DOI PMC EPMC V
Schalekamp,M.A.D.H., Deinum,J. and Danser,A.H.J. Short-Lived Active Prorenin: Precursor of So-Called Native Prorenin Hypertension (2024) 81, 1190-1193. PubMed Europe PubMed DOI PMC EPMC
Shen,Y., Lotenberg,K., Zaworski,J., Broeker,K.A., Vasseur,F., Louedec,L., Placier,S., Frere,P., Verpont,M.C., Galichon,P., Buob,D., Hadchouel,J., Terzi,F., Chatziantoniou,C. and Calmont,A. Neuropilin-1 regulates renin synthesis in juxtaglomerular cells J Physiol (2024) 602, 1815-1833. PubMed Europe PubMed DOI
Triebel,H. and Castrop,H. The renin angiotensin aldosterone system Pflugers Arch (2024) 476, 705-713. PubMed Europe PubMed DOI V
Zhang,Y., Martin,B., Spies,M.A., Roberts,S.M., Nott,J., Goodfellow,R.X., Nelson,A.F.M., Blain,S.J., Redondo,E., Nester,C.M. and Smith,R.J.H. Renin and renin blockade have no role in complement activity Kidney Int (2024) 105, 328-337. PubMed Europe PubMed DOI PMC EPMC

2023

Akther,J., Nabi,A.H.M.N., Ohno,S., Yokogawa,T., Nakagawa,T., Suzuki,F. and Ebihara,A. Corrigendum to "establishing a novel assay system for measuring renin concentration using cost effective recombinant ovine angiotensinogen" Heliyon (2023) 9, e13123-e13123. PubMed Europe PubMed DOI PMC EPMC
Loganathan,L., Sankar,J., Rajendran,K. and Muthusamy,K. Theoretical investigation on known renin inhibitors and generation of ligand-based pharmacophore models for hypertension treatment J Biomol Struct Dyn (2023) , 1-10. PubMed Europe PubMed DOI
Moguel-Concha,D.D.R., Borges-Martinez,J.E., Cid-Gallegos,M.S., Juarez-Chairez,M.F., Gomez-Gomez,A.L., Tellez-Medina,D.I. and Jimenez-Martinez,C. Antioxidant and Renin Inhibitory Activities of Peptides from Food Proteins on Hypertension: A Review Plant Foods Hum Nutr (2023) 78, 493-505. PubMed Europe PubMed DOI V
Ostrowski,J. and Kurkus,J. Robert Tigerstedt and the Discovery of Renin Exp Clin Transplant (2023) 21, 62-66. PubMed Europe PubMed DOI
Wang,C., Wang,Z., Xu,J., Ma,H., Jin,K., Xu,T., Pan,X., Feng,X. and Zhang,W. C3aR Antagonist Alleviates C3a Induced Tubular Profibrotic Phenotype Transition via Restoring PPARalpha/CPT-1alpha Mediated Mitochondrial Fatty Acid Oxidation in Renin-Dependent Hypertension Front Biosci (Landmark Ed) (2023) 28, 238-238. PubMed Europe PubMed DOI

2022

Iijima,D., Sugama,H., Takahashi,Y., Hirai,M., Togashi,Y., Xie,J., Shen,J., Ke,Y., Akatsuka,H., Kawaguchi,T., Takedomi,K., Kashima,A., Nishio,M., Inui,Y., Yoneda,H., Xia,G. and Iijima,T. Discovery of SPH3127: A Novel, Highly Potent, and Orally Active Direct Renin Inhibitor J Med Chem (2022) 65, 10882-10897. PubMed Europe PubMed DOI I
Iijima,D., Sugama,H., Awai,N., Takahashi,Y., Togashi,Y., Takebe,T., Xie,J., Shen,J., Ke,Y., Akatsuka,H., Kawaguchi,T., Takedomi,K., Kashima,A., Nishio,M., Inui,Y., Yoneda,H., Xia,G. and Iijima,T. Discovery of Novel 2-Carbamoyl Morpholine Derivatives as Highly Potent and Orally Active Direct Renin Inhibitors ACS Med Chem Lett (2022) 13, 1351-1357. PubMed Europe PubMed DOI PMC EPMC
Piesanen,J., Valjakka,J., Niemela,S., Borgenstrom,M., Nikkari,S., Hytonen,V., Maatta,J. and Kunnas,T. Hepcidin is potential regulator for renin activity PLoS ONE (2022) 17, e0267343-e0267343. PubMed Europe PubMed DOI PMC EPMC
Senbonmatsu,T. Prorenin: What are its functions? Hypertens Res (2022) 45, 2021-2023. PubMed Europe PubMed DOI
Yokota,H., Hayashi,H., Hanaguri,J., Yamagami,S., Kushiyama,A., Nakagami,H. and Nagaoka,T. Effect of prorenin peptide vaccine on the early phase of diabetic retinopathy in a murine model of type 2 diabetes PLoS ONE (2022) 17, e0262568-e0262568. PubMed Europe PubMed DOI PMC EPMC

2021

Akther,J., Das,A., Rahman,M.A., Saha,S.K., Hosen,M.I., Ebihara,A., Nakagawa,T., Suzuki,F. and Nabi,A.H.M.N. Non-coding Single Nucleotide Variants of Renin and the (Pro)renin Receptor are Associated with Polygenic Diseases in a Bangladeshi Population Biochem Genet (2021) PubMed Europe PubMed DOI M
Grahame,D.A.S., Dupuis,J.H., Bryksa,B.C., Tanaka,T. and Yada,R.Y. Improving the alkaline stability of pepsin through rational protein design using renin, an alkaline-stable aspartic protease, as a structural and functional reference Enzyme Microb Technol (2021) 150, 109871-109871. PubMed Europe PubMed DOI
Ma,S., Henderson,J.A. and Shen,J. Exploring the pH-Dependent Structure-Dynamics-Function Relationship of Human Renin J Chem Inf Model (2021) 61, 400-407. PubMed Europe PubMed DOI
Murray,J.B., Mikhael,C., Han,G., de Faria,L.P., Rody,W.J., Jr. and Holliday,L.S. Activation of (pro)renin by (pro)renin receptor in extracellular vesicles from osteoclasts Sci Rep (2021) 11, 9214-9214. PubMed Europe PubMed DOI PMC EPMC
Prieto,M.C., Gonzalez,A.A., Visniauskas,B. and Navar,L.G. The evolving complexity of the collecting duct renin-angiotensin system in hypertension Nat Rev Nephrol (2021) PubMed Europe PubMed DOI
Refaey,R.H., El-Ashrey,M.K. and Nissan,Y.M. Repurposing of renin inhibitors as SARS-COV-2 main protease inhibitors: A computational study Virology (2021) 554, 48-54. PubMed Europe PubMed DOI PMC EPMC I

2020

Abdel Ghafar,M.T. An overview of the classical and tissue-derived renin-angiotensin-aldosterone system and its genetic polymorphisms in essential hypertension Steroids (2020) 163, 108701-108701. PubMed Europe PubMed DOI
Alhenc-Gelas,F. A new channel for the control of renin secretion in juxtaglomerular cells Kidney Int (2020) 98, 543-545. PubMed Europe PubMed DOI
Alsufyani,H.A. and Docherty,J.R. The renin angiotensin aldosterone system and COVID-19 Saudi Pharm J (2020) 28, 977-984. PubMed Europe PubMed DOI PMC EPMC V
Bartova,E., Legartova,S., Krejci,J. and Arcidiacono,O.A. Cell differentiation and aging accompanied by depletion of the ACE2 protein Aging (Albany NY) (2020) 12, 22495-22508. PubMed Europe PubMed DOI
Dilliott,A.A., Wang,J., Brown,E., Singh,G., Shkrum,M.J., Clin,M., Rupar,C.A., Hegele,R.A. and Siu,V.M. A novel homozygous variant in REN in a family presenting with classic features of disorders involving the renin-angiotensin pathway, without renal tubular dysgenesis Am J Med Genet A (2020) 182, 2284-2290. PubMed Europe PubMed DOI
Docherty,K.F., Campbell,R.T., Brooksbank,K.J.M., Godeseth,R.L., Forsyth,P., McConnachie,A., Roditi,G., Stanley,B., Welsh,P., Jhund,P.S., Petrie,M.C. and McMurray,J.J.V. Rationale and methods of a randomized trial evaluating the effect of neprilysin inhibition on left ventricular remodelling ESC Heart Fail (2020) PubMed Europe PubMed DOI I
Feng,Y., Peng,K., Luo,R., Wang,F. and Yang,T. Site-1 Protease-Derived Soluble (Pro)Renin Receptor Contributes to Angiotensin II-Induced Hypertension in Mice Hypertension (2020) , HYPERTENSIONAHA12015100-HYPERTENSIONAHA12015100. PubMed Europe PubMed DOI
Grahame,D.S.A., Dupuis,J.H., Bryksa,B.C., Tanaka,T. and Yada,R.Y. Comparative bioinformatic and structural analyses of pepsin and renin Enzyme Microb Technol (2020) 141, 109632-109632. PubMed Europe PubMed DOI
Hartford,M., Herlitz,H., Perers,E., Karlsson,T., Herlitz,J., Persson,A. and Caidahl,K. Plasma renin activity has a complex prognostic role in patients with acute coronary syndromes Int J Cardiol (2020) PubMed Europe PubMed DOI
Kobayashi,Y., Haze,T., Yano,Y., Tamura,K., Kurihara,I., Ichijo,T., Yoneda,T., Katabami,T., Tsuiki,M., Wada,N., Ogawa,Y., Kawashima,J., Sone,M., Inagaki,N., Yamada,T., Okamoto,R., Fujita,M., Kamemura,K., Yamamoto,K., Izawa,S., Tanabe,A. and Naruse,M. Associations Between Changes in Plasma Renin Activity and Aldosterone Concentrations and Changes in Kidney Function After Treatment for Primary Aldosteronism Kidney Int Rep (2020) 5, 1291-1297. PubMed Europe PubMed DOI PMC EPMC
Kurbel,S. The renin-angiotensin system in COVID-19: Why ACE2 targeting by coronaviruses produces higher mortality in elderly hypertensive patients? Bioessays (2020) , e2000112-e2000112. PubMed Europe PubMed DOI
Liu,Y., Lin,Y., Zhang,M.M., Li,X.H., Liu,Y.Y., Zhao,J. and Shi,L. The relationship of plasma renin, angiotensin, and aldosterone levels to blood pressure variability and target organ damage in children with essential hypertension BMC Cardiovasc Disord (2020) 20, 296-296. PubMed Europe PubMed DOI PMC EPMC I
Lou,L.L., Xie,L., Hu,Y., Chen,L.N., Liang,P., Shi,F., Liu,C.J. and Liu,H.M. [Association of age distribution with the expression of angiotensin-converting enzyme 2 in lung tissues in severe acute respiratory syndrome coronavirus 2 infection: reflections from the study of RAS pathway expression in mice] Zhongguo Dang Dai Er Ke Za Zhi (2020) 22, 1119-1124. PubMed Europe PubMed PMC EPMC
Ma,W.J., Lou,Y., Bian,J., Cai,J., Zhang,H.M. and Zhou,X.L. [Application of aldosterone/direct renin ratio before drug washout in the screening of primary aldosteronism] Zhonghua Yi Xue Za Zhi (2020) 100, 3250-3254. PubMed Europe PubMed DOI
Moin,A.S.M., Sathyapalan,T., Atkin,S.L. and Butler,A.E. Renin-Angiotensin System overactivation in polycystic ovary syndrome, a risk for SARS-CoV-2 infection? Metabol Open (2020) 7, 100052-100052. PubMed Europe PubMed DOI PMC EPMC
Salman,A.A., Salman,M.A., Shawkat,M., Hassan,S.A., Saad,E.H., Hussein,A.M., Refaie,O.R.M., Tourky,M.S., Shaaban,H.E., Abd Allah,N., El Domiaty,H.F. and Elkassar,H. Effect of Laparoscopic Sleeve Gastrectomy on Vasoactive Mediators in Obese Hypertensive Patients: A Prospective Study Clin Endocrinol (Oxf) (2020) PubMed Europe PubMed DOI
Siljee,S., Pilkington,T., Brasch,H.D., Bockett,N., Patel,J., Paterson,E., Davis,P.F. and Tan,S.T. Cancer Stem Cells in Head and Neck Metastatic Malignant Melanoma Express Components of the Renin-Angiotensin System Life (Basel) (2020) 10 PubMed Europe PubMed DOI
Urushihara,M., Kondo,S., Kinoshita,Y., Ozaki,N., Jamba,A., Nagai,T., Fujioka,K., Hattori,T. and Kagami,S. (Pro)renin receptor promotes crescent formation via the ERK1/2 and Wnt/beta-catenin pathways in glomerulonephritis Am J Physiol Renal Physiol (2020) 319, F571-F571. PubMed Europe PubMed DOI
Wanka,H., Lutze,P., Staar,D., Bracke,K., Golchert,J. and Peters,J. Angiotensin dependent and angiotensin independent protective effects of renin-b in H9c2 cells after anoxia Sci Rep (2020) 10, 19689-19689. PubMed Europe PubMed DOI PMC EPMC

2019

Yan,Y., Zhou,A., Carrell,R.W. and Read,R.J. Structural basis for the specificity of renin-mediated angiotensinogen cleavage J Biol Chem (2019) 294, 2353-2364. PubMed Europe PubMed DOI S

2018

Nakano,D. and Nishiyama,A. A novel role of renin inhibitor in the complement cascade Kidney Int (2018) 94, 650-652. PubMed Europe PubMed DOI I
Strecker,C. and Meyer,B. Plasticity of the binding site of renin: optimized selection of protein structures for ensemble docking J Chem Inf Model (2018) 58, 1121-1131. PubMed Europe PubMed DOI I
Tavassoli,Z., Taghdir,M. and Ranjbar,B. Renin inhibition by soyasaponin I: a potent native anti-hypertensive compound J Biomol Struct Dyn (2018) 36, 166-176. PubMed Europe PubMed DOI
Tokuhara,H., Imaeda,Y., Fukase,Y., Iwanaga,K., Taya,N., Watanabe,K., Kanagawa,R., Matsuda,K., Kajimoto,Y., Kusumoto,K., Kondo,M., Snell,G., Behnke,C.A. and Kuroita,T. Discovery of benzimidazole derivatives as orally active renin inhibitors: optimization of 3,5-disubstituted piperidine to improve pharmacokinetic profile Bioorg Med Chem (2018) 26, 3261-3286. PubMed Europe PubMed DOI I

2017

Cloudsdale,I.S., Dickson JK Jr, Barta,T.E., Grella,B.S., Smith,E.D., Kulp JL 3rd, Guarnieri,F. and Kulp JL Jr Design, synthesis and biological evaluation of renin inhibitors guided by simulated annealing of chemical potential simulations Bioorg Med Chem (2017) 25, 3947-3963. PubMed Europe PubMed DOI I
Fu,Y., Alashi,A.M., Young,J.F., Therkildsen,M. and Aluko,R.E. Enzyme inhibition kinetics and molecular interactions of patatin peptides with angiotensin I-converting enzyme and renin Int J Biol Macromol (2017) 101, 207-213. PubMed Europe PubMed DOI I
Lawhorn,B.G., Tran,T., Hong,V.S., Morgan,L.A., Le,B.T., Harpel,M.R., Jolivette,L., Diaz,E., Schwartz,B., Gross,J.W., Tomaszek,T., Semus,S., Concha,N., Smallwood,A., Holt,D.A. and Kallander,L.S. Discovery of renin inhibitors containing a simple aspartate binding moiety that imparts reduced P450 inhibition Bioorg Med Chem Lett (2017) 27, 4838-4843. PubMed Europe PubMed DOI I
Marszalek,D., Goldnik,A., Winiecka,I., Jaworsk,P. and Mazurek Aleksander,P. New renin inhibitors - stability and activity determination. Part IV Acta Pol Pharm (2017) 74, 393-399. PubMed Europe PubMed I
Shinohara,K., Nakagawa,P., Gomez,J., Morgan,D.A., Littlejohn,N.K., Folchert,M.D., Weidemann,B.J., Liu,X., Walsh,S.A., Ponto,L.L., Rahmouni,K., Grobe,J.L. and Sigmund,C.D. Selective deletion of renin-b in the brain alters drinking and metabolism Hypertension (2017) 70, 990-997. PubMed Europe PubMed DOI K
Wilkinson,M.C., Nightingale,D.J.H., Harrison,R.A. and Wagstaff,S.C. Isolation and characterization of renin-like aspartic-proteases from Echis ocellatus venom Toxicon (2017) 137, 92-94. PubMed Europe PubMed DOI I

2016

Imaeda,Y., Tawada,M., Suzuki,S., Tomimoto,M., Kondo,M., Tarui,N., Sanada,T., Kanagawa,R., Snell,G., Behnke,C.A., Kubo,K. and Kuroita,T. Structure-based design of a new series of N-(piperidin-3-yl)pyrimidine-5-carboxamides as renin inhibitors Bioorg Med Chem (2016) 24, 5771-5780. PubMed Europe PubMed DOI I
Imaeda,Y., Tokuhara,H., Fukase,Y., Kanagawa,R., Kajimoto,Y., Kusumoto,K., Kondo,M., Snell,G., Behnke,C.A. and Kuroita,T. Discovery of TAK-272: a novel, potent, and orally active renin inhibitor ACS Med Chem Lett (2016) 7, 933-938. PubMed Europe PubMed DOI PMC EPMC I
Ramanathan,G., Elumalai,R., Periyasamy,S. and Lakkakula,B.V. Renin gene rs1464816 polymorphism contributes to chronic kidney disease progression in ADPKD J Biomed Sci (2016) 23, 1-1. PubMed Europe PubMed DOI PMC EPMC M
Shinohara,K., Liu,X., Morgan,D.A., Davis,D.R., Sequeira-Lopez,M.L., Cassell,M.D., Grobe,J.L., Rahmouni,K. and Sigmund,C.D. Selective deletion of the brain-specific isoform of renin causes neurogenic hypertension Hypertension (2016) 68, 1385-1392. PubMed Europe PubMed DOI K
Tawada,M., Suzuki,S., Imaeda,Y., Oki,H., Snell,G., Behnke,C.A., Kondo,M., Tarui,N., Tanaka,T., Kuroita,T. and Tomimoto,M. Novel approach of fragment-based lead discovery applied to renin inhibitors Bioorg Med Chem (2016) 24, 6066-6074. PubMed Europe PubMed DOI I
Winiecka,I., Jaworski,P., Mazurek,A.P., Marszalek,D., Goldnik,A. and Sokulski,D. Novel renin inhibitors containing derivatives of N-alkylleucyl-beta-hydroxy-gamma-amino acids J Pept Sci (2016) 22, 106-115. PubMed Europe PubMed DOI I

2015

da Mota,E.G., Duarte,M.H., Da Cunha,E.F.F. and Freitas,M.P. Theoretical design of new indole-3-carboxamide derivatives as renin inhibitors Med Chem Res (2015) 24, 3097-3106. DOI I
Lorthiois,E., Cumin,F., Ehrhardt,C., Kosaka,T., Sellner,H., Ostermann,N., Francotte,E., Wagner,T. and Maibaum,J. trans-(3S,4S)-Disubstituted pyrrolidines as inhibitors of the human aspartyl protease renin. Part I: Prime site exploration using an amino linker Bioorg Med Chem Lett (2015) 25, 1782-1786. PubMed Europe PubMed DOI I
McKittrick,B.A., Caldwell,J.P., Bara,T., Boykow,G., Chintala,M., Clader,J., Czarniecki,M., Courneya,B., Duffy,R., Fleming,L., Giessert,R., Greenlee,W.J., Heap,C., Hong,L., Huang,Y., Iserloh,U., Josien,H., Khan,T., Korfmacher,W., Liang,X., Mazzola,R., Mitra,S., Moore,K., Orth,P., Rajagopalan,M., Roy,S., Sakwa,S., Strickland,C., Vaccaro,H., Voigt,J., Wang,H., Wong,J., Zhang,R. and Zych,A. Iminopyrimidinones: a novel pharmacophore for the development of orally active renin inhibitors Bioorg Med Chem Lett (2015) 25, 1592-1596. PubMed Europe PubMed DOI I
Park,J., Song,K., Jang,Y. and Kim Yoon,S. A polymorphism of the renin gene rs6682082 is associated with essential hypertension risk and blood pressure levels in Korean women Yonsei Med J (2015) 56, 227-234. PubMed Europe PubMed DOI M
Raff,H., Gehrand,A., Bruder,E.D., Hoffman,M.J., Engeland,W.C. and Moreno,C. Renin knockout rat: control of adrenal aldosterone and corticosterone synthesis in vitro and adrenal gene expression Am J Physiol Regul Integr Comp Physiol (2015) , R73-R77. PubMed Europe PubMed DOI K
Sellner,H., Cottens,S., Cumin,F., Ehrhardt,C., Kosaka,T., Lorthiois,E., Ostermann,N., Webb,R.L., Rigel,D.F., Wagner,T. and Maibaum,J. trans-3,4-Disubstituted pyrrolidines as inhibitors of the human aspartyl protease renin. Part II: Prime site exploration using an oxygen linker Bioorg Med Chem Lett (2015) 25, 1787-1791. PubMed Europe PubMed DOI I
Sequeira-Lopez,M.L., Nagalakshmi,V.K., Li,M., Sigmund,C.D. and Gomez,R.A. Vascular versus tubular renin: role in kidney development Am J Physiol Regul Integr Comp Physiol (2015) 309, R650-R657. PubMed Europe PubMed DOI K
Sharma,M.C. Structural insights into mode of actions of novel substituted 4- and 6-azaindole-3-carboxamides analogs as renin inhibitors: molecular modeling studies Med Chem Res (2015) 24, 1038-1059. DOI I
Sun,X., Wen,X., Chen,Y.Y., Shi,C., Gao,C., Wu,Y., Wang,L.J., Yang,X.H. and Sun,H. Discovery of highly potent renin inhibitors potentially interacting with the S3' subsite of renin Eur J Med Chem (2015) 103, 269-288. PubMed Europe PubMed DOI I
Tzoupis,H., Leonis,G., Avramopoulos,A., Reis,H., Czyznikowska,Z., Zerva,S., Vergadou,N., Peristeras,L.D., Papavasileiou,K.D., Alexis,M.N., Mavromoustakos,T. and Papadopoulos,M.G. Elucidation of the binding mechanism of renin using a wide array of computational techniques and biological assays J Mol Graph Model (2015) 62, 138-149. PubMed Europe PubMed DOI
Zhou,Z., Cheng,C. and Li,Y. Structure-based design and optimization of antihypertensive peptides to obtain high inhibitory potency against both renin and angiotensin I-converting enzyme SAR QSAR Environ Res (2015) 26, 1001-1016. PubMed Europe PubMed DOI I

2014

Bras,N.F., Fernandes,P.A. and Ramos,M.J. Molecular dynamics studies on both bound and unbound renin protease J Biomol Struct Dyn (2014) 32, 351-363. PubMed Europe PubMed DOI
Calixto,A.R., Bras,N.F., Fernandes,P.A. and Ramos,M.J. Reaction mechanism of human renin studied by quantum mechanics/molecular mechanics (QM/MM) calculations ACS Catal (2014) 4, 3869-3876. DOI
Ehara,T., Irie,O., Kosaka,T., Kanazawa,T., Breitenstein,W., Grosche,P., Ostermann,N., Suzuki,M., Kawakami,S., Konishi,K., Hitomi,Y., Toyao,A., Gunji,H., Cumin,F., Schiering,N., Wagner,T., Rigel,D.F., Webb,R.L., Maibaum,J. and Yokokawa,F. Structure-based design of substituted piperidines as a new class of highly efficacious oral direct renin inhibitors ACS Med Chem Lett (2014) 5, 787-792. PubMed Europe PubMed DOI PMC EPMC I
Konoshita,T., Nakaya,T., Sakai,A., Yamada,M., Ichikawa,M., Sato,S., Imagawa,M., Fujii,M., Yamamoto,K., Makino,Y., Arakawa,K., Suzuki,J. and Ishizuka,T. Determinants of plasma renin activity: role of a human renin gene variant as a genetic factor Medicine (Baltimore) (2014) 93, e354-e354. PubMed Europe PubMed DOI M
Lu,X., Krop,M., Batenburg,W.W., Musterd-Bhaggoe,U.M., Garrelds,I.M. and Danser,A.H. Renin inhibitor VTP-27999 differs from aliskiren: focus on their intracellular accumulation and the (pro)renin receptor J Hypertens (2014) 32, 1255-1263. PubMed Europe PubMed DOI I
Marszalek,D., Goldnik,A., Mazurek,A.P., Winiecka,I., Jaworski,P., Szerszan,S., Kozikowska,E. and Pawlik,T. New renin inhibitors - stability and activity determination. Part II Acta Pol Pharm (2014) 71, 555-561. PubMed Europe PubMed I
Marszalek,D., Goldnik,A., Mazurek,A.P., Winiecka,I. and Jaworskpi,P. New renin inhibitors - stability and activity determination. Part I Acta Pol Pharm (2014) 71, 545-553. PubMed Europe PubMed I
Mori,Y., Iwamoto,M., Mori,K., Yoshida,M., Honda,T., Nagayama,T. and Nishi,T. An efficient synthesis of (3S,5S)-5-[3,3-dimethyl-1-(o-tolyl)-6-OXO-2H- pyridin-4-YL]- piperidine-3-carboxamide as potent renin inhibitor Heterocycles (2014) 89, 1413-1426. DOI I
Shieh,W.-C., Du,Z., Kim,H., Liu,Y. and Prashad,M. Development of a total telescoped synthesis of a renin inhibitor containing 3,4,5-substituted piperidine with sterically hindered amide bonds Org Process Res Dev (2014) 18, 1339-1344. DOI I
Weber,M.A. John Laragh and the renin thesis: creating a paradigm Am J Hypertens (2014) 27, 1008-1009. PubMed Europe PubMed DOI V
Winiecka,I., Marszalek,D., Goldnik,A., Jaworski,P. and Mazurek,A.P. New renin inhibitors containing phenylalanylhistidyl-gamma-amino acid derivatives in P3 - P1' position Acta Pol Pharm (2014) 71, 59-69. PubMed Europe PubMed I
Winiecka,I., Marszalek,D., Goldnik,A., Jaworski,P. and Mazurek,A.P. Novel renin inhibitors containing a non-peptide aminoalkanoyl moiety at P1-P1' position Pharmazie (2014) 69, 263-270. PubMed Europe PubMed DOI I
Xa,L.K., Lacombe,M.J., Mercure,C., Lazure,C. and Reudelhuber,T.L. General lysosomal hydrolysis can process prorenin accurately Am J Physiol Regul Integr Comp Physiol (2014) 307, R505-R513. PubMed Europe PubMed DOI
Xiang,Y., Song,J. and Zhang,Z. Topomer CoMFA and virtual screening studies of azaindole class renin inhibitors Comb Chem High Throughput Screen (2014) 17, 458-472. PubMed Europe PubMed DOI I

2013

Harmsen,R.A.G., Sivertsen,A., Michetti,D., Brandsdal,B.O., Sydnes,L.K. and Haug,B.E. Synthesis and docking of novel piperidine renin inhibitors Monatsh Chem (2013) 144, 479-494. DOI I
Krop,M., Lu,X., Verdonk,K., Schalekamp,M.A., van Gool,J.M., McKeever,B.M., Gregg,R. and Danser,A.H. New renin inhibitor VTP-27999 alters renin immunoreactivity and does not unfold prorenin Hypertension (2013) 61, 1075-1082. PubMed Europe PubMed DOI I
Lorthiois,E., Breitenstein,W., Cumin,F., Ehrhardt,C., Francotte,E., Jacoby,E., Ostermann,N., Sellner,H., Kosaka,T., Webb,R.L., Rigel,D.F., Hassiepen,U., Richert,P., Wagner,T. and Maibaum,J. The discovery of novel potent trans-3,4-disubstituted pyrrolidine inhibitors of the human aspartic protease renin from in silico three-dimensional (3D) pharmacophore searches J Med Chem (2013) 56, 2207-2217. PubMed Europe PubMed DOI I
Michida,M., Takayanagi,Y., Imai,M., Furuya,Y., Kimura,K., Kitawaki,T., Tomori,H. and Kajino,H. Convergent asymmetric synthesis of a renin inhibitor: a highly efficient construction method of three stereogenic centers Org Process Res Dev (2013) 17, 1430-1439. DOI I
Mori,Y., Ogawa,Y., Mochizuki,A., Nakamura,Y., Fujimoto,T., Sugita,C., Miyazaki,S., Tamaki,K., Nagayama,T., Nagai,Y., Inoue,S., Chiba,K. and Nishi,T. Synthesis and optimization of novel (3S,5R)-5-(2,2-dimethyl-5-oxo-4-phenylpiperazin-1-yl)piperidine-3-carboxamides as orally active renin inhibitors Bioorg Med Chem (2013) 21, 5907-5922. PubMed Europe PubMed DOI I
Nakamura,Y., Fujimoto,T., Ogawa,Y., Namiki,H., Suzuki,S., Asano,M., Sugita,C., Mochizuki,A., Miyazaki,S., Tamaki,K., Nagai,Y., Inoue,S., Nagayama,T., Kato,M., Chiba,K., Takasuna,K. and Nishi,T. Lead optimization of 5-amino-6-(2,2-dimethyl-5-oxo-4-phenylpiperazin-1-yl)-4-hydroxyhexanamides to reduce a cardiac safety issue: Discovery of DS-8108b, an orally active renin inhibitor Bioorg Med Chem (2013) 21, 3175-3196. PubMed Europe PubMed DOI I
Ostermann,N., Ruedisser,S., Ehrhardt,C., Breitenstein,W., Marzinzik,A., Jacoby,E., Vangrevelinghe,E., Ottl,J., Klumpp,M., Hartwieg,J.C., Cumin,F., Hassiepen,U., Trappe,J., Sedrani,R., Geisse,S., Gerhartz,B., Richert,P., Francotte,E., Wagner,T., Kromer,M., Kosaka,T., Webb,R.L., Rigel,D.F., Maibaum,J. and Baeschlin,D.K. A novel class of oral direct renin inhibitors: highly potent 3,5-disubstituted piperidines bearing a tricyclic P3-P1 pharmacophore J Med Chem (2013) 56, 2196-2206. PubMed Europe PubMed DOI I
Subramanian,G. Computational modeling and design of renin inhibitors Bioorg Med Chem Lett (2013) 23, 460-465. PubMed Europe PubMed DOI I
Subramanian,G. and Rao,S.N. Comprehending renin inhibitor's binding affinity using structure-based approaches Bioorg Med Chem Lett (2013) 23, 6667-6672. PubMed Europe PubMed DOI I

2012

Bras,N.F., Ramos,M.J. and Fernandes,P.A. The catalytic mechanism of mouse renin studied with QM/MM calculations Phys Chem Chem Phys (2012) 14, 12605-12613. PubMed Europe PubMed DOI
Fournier,P.A., Arbour,M., Cauchon,E., Chen,A., Chefson,A., Ducharme,Y., Falgueyret,J.P., Gagne,S., Grimm,E., Han,Y., Houle,R., Lacombe,P., Levesque,J.F., MacDonald,D., Mackay,B., McKay,D., Percival,M.D., Ramtohul,Y., St-Jacques,R. and Toulmond,S. Design and synthesis of potent, isoxazole-containing renin inhibitors Bioorg Med Chem Lett (2012) 22, 2670-2674. PubMed Europe PubMed DOI I
Ishchenko,A., Liu,Z., Lindblom,P., Wu,G., Jim,K.C., Gregg,R.D., Claremon,D.A. and Singh,S.B. Structure-based design technology contour and its application to the design of renin inhibitors J Chem Inf Model (2012) 52, 2089-2097. PubMed Europe PubMed DOI I
Iwai,M., Senba,I., Kanno,H., Nakaoka,H., Inaba,S. and Horiuchi,M. Renin inhibitors inhibited the activity of recombinant human renin but not activity in healthy human plasma Clin Lab (2012) 58, 291-298. PubMed Europe PubMed
Jing,T., Feng,J., Zuo,Y., Ran,B., Liu,J. and He,G. Exploring the substructural space of indole-3-carboxamide derivatives binding to renin: a novel active-site spatial partitioning approach J Mol Model (2012) 18, 4417-4426. PubMed Europe PubMed DOI I
Kunikullaya,U., Ananthakrishnan,V. and Goturu,J. Robert Tigerstedt and the discovery of renin - a revisit Int J Cardiol (2012) 158, 1-5. PubMed Europe PubMed DOI
Lacombe,P., Arbour,M., Aspiotis,R., Cauchon,E., Chen,A., Dube,D., Falgueyret,J.P., Fournier,P.A., Gallant,M., Grimm,E., Han,Y., Juteau,H., Liu,S., Mellon,C., Ramtohul,Y., Simard,D., St-Jacques,R. and Tsui,G.C. 3,4-Diarylpiperidines as potent renin inhibitors Bioorg Med Chem Lett (2012) 22, 1953-1957. PubMed Europe PubMed DOI I
Long,Y., Zhang,L.F., Zhang,Y. and Zhang,C.Y. Single quantum dot based nanosensor for renin assay Anal Chem (2012) 84, 8846-8852. PubMed Europe PubMed DOI A
Morales,R., Watier,Y. and Bocskei,Z. Human prorenin structure sheds light on a novel mechanism of its autoinhibition and on its non-proteolytic activation by the (pro)renin receptor J Mol Biol (2012) 421, 100-111. PubMed Europe PubMed DOI S
Mori,Y., Ogawa,Y., Mochizuki,A., Nakamura,Y., Sugita,C., Miyazaki,S., Tamaki,K., Matsui,Y., Takahashi,M., Nagayama,T., Nagai,Y., Inoue,S. and Nishi,T. Design and discovery of new (3S,5R)-5-[4-(2-chlorophenyl)-2,2-dimethyl-5-oxopiperazin-1-yl]piperidine-3-carboxamides as potent renin inhibitors Bioorg Med Chem Lett (2012) 22, 7677-7682. PubMed Europe PubMed DOI I
Nakamura,Y., Fujimoto,T., Ogawa,Y., Sugita,C., Miyazaki,S., Tamaki,K., Takahashi,M., Matsui,Y., Nagayama,T., Manabe,K., Mizuno,M., Masubuchi,N., Chiba,K. and Nishi,T. Discovery of DS-8108b, a novel orally bioavailable renin inhibitor ACS Med Chem Lett (2012) 3, 754-758. PubMed Europe PubMed DOI I
Nakamura,Y., Sugita,C., Meguro,M., Miyazaki,S., Tamaki,K., Takahashi,M., Nagai,Y., Nagayama,T., Kato,M., Suemune,H. and Nishi,T. Design and optimization of novel (2S,4S,5S)-5-amino-6-(2,2-dimethyl-5-oxo-4-phenylpiperazin-1-yl)-4-hydroxy-2-isopropylhexanamides as renin inhibitors Bioorg Med Chem Lett (2012) 22, 4561-4566. PubMed Europe PubMed DOI I
Nurun Nabi,A.H.M., Suzuki,F. and Inagami,T. Renin [ISSN:978-0-12-407744-7] (2012) 3, 71-82. DOI
Udenigwe,C.C., Li,H. and Aluko,R.E. Quantitative structure-activity relationship modeling of renin-inhibiting dipeptides Amino Acids (2012) 42, 1379-1386. PubMed Europe PubMed DOI I
Zhang,J., Preda,D.V., Vasquez,K.O., Morin,J., Delaney,J., Bao,B., Percival,M.D., Xu,D., McKay,D., Klimas,M., Bednar,B., Sur,C., Gao,D.Z., Madden,K., Yared,W., Rajopadhye,M. and Peterson,J.D. A fluorogenic near-infrared imaging agent for quantifying plasma and local tissue renin activity in vivo and ex vivo Am J Physiol Renal Physiol (2012) 303, F593-F603. PubMed Europe PubMed DOI L

2011

Al-Nadaf,A.H. and Taha,M.O. Discovery of new renin inhibitory leads via sequential pharmacophore modeling, QSAR analysis, in silico screening and in vitro evaluation J Mol Graph Model (2011) 29, 843-864. PubMed Europe PubMed DOI I
Aspiotis,R., Chen,A., Cauchon,E., Dube,D., Falgueyret,J.P., Gagne,S., Gallant,M., Grimm,E.L., Houle,R., Juteau,H., Lacombe,P., Laliberte,S., Levesque,J.F., MacDonald,D., McKay,D., Percival,M.D., Roy,P., Soisson,S.M. and Wu,T. The discovery and synthesis of potent zwitterionic inhibitors of renin Bioorg Med Chem Lett (2011) 21, 2430-2436. PubMed Europe PubMed DOI I
Beck,B.B., Trachtman,H., Gitman,M., Miller,I., Sayer,J.A., Pannes,A., Baasner,A., Hildebrandt,F. and Wolf,M.T. Autosomal dominant mutation in the signal peptide of renin in a kindred with anemia, hyperuricemia, and CKD Am J Kidney Dis (2011) 58, 821-825. PubMed Europe PubMed DOI M
Brakch,N., Allemandou,F., Keller,I. and Nussberger,J. The renin prosequence enhances constitutive secretion of renin and optimizes renin activity Curr Neurovasc Res (2011) 8, 121-130. PubMed Europe PubMed DOI
Chen,A., Campeau,L.C., Cauchon,E., Chefson,A., Ducharme,Y., Dube,D., Falgueyret,J.P., Fournier,P.A., Gagne,S., Grimm,E., Han,Y., Houle,R., Huang,J.Q., Lacombe,P., Laliberte,S., Levesque,J.F., Liu,S., MacDonald,D., Mackay,B., McKay,D., Percival,M.D., Regan,C., Regan,H., St-Jacques,R. and Toulmond,S. Renin inhibitors for the treatment of hypertension: design and optimization of a novel series of pyridone-substituted piperidines Bioorg Med Chem Lett (2011) 21, 3970-3975. PubMed Europe PubMed DOI I
Chen,A., Cauchon,E., Chefson,A., Dolman,S., Ducharme,Y., Dube,D., Falgueyret,J.P., Fournier,P.A., Gagne,S., Gallant,M., Grimm,E., Han,Y., Houle,R., Huang,J.Q., Hughes,G., Juteau,H., Lacombe,P., Lauzon,S., Levesque,J.F., Liu,S., MacDonald,D., Mackay,B., McKay,D., Percival,M.D., St-Jacques,R. and Toulmond,S. Renin inhibitors for the treatment of hypertension: design and optimization of a novel series of tertiary alcohol-bearing piperidines Bioorg Med Chem Lett (2011) 21, 3976-3981. PubMed Europe PubMed DOI I
Chen,A., Aspiotis,R., Campeau,L.C., Cauchon,E., Chefson,A., Ducharme,Y., Falgueyret,J.P., Gagne,S., Han,Y., Houle,R., Laliberte,S., Larouche,G., Levesque,J.F., McKay,D. and Percival,D. Renin inhibitors for the treatment of hypertension: design and optimization of a novel series of spirocyclic piperidines Bioorg Med Chem Lett (2011) 21, 7399-7404. PubMed Europe PubMed DOI I
Fisher,N.D. and Meagher,E.A. Renin inhibitors J Clin Hypertens (Greenwich) (2011) 13, 662-666. PubMed Europe PubMed DOI I
Ghasemi,J.B. and Pirhadi,S. Docking alignment-3D-qsar of a new class of potent and non-chiral indole-3-carboxamide-based renin inhibitors Collect Czech Chem Commun (2011) 76, 1447-1469. DOI I
Jia,L., Simpson,R.D., Yuan,J., Xu,Z., Zhao,W., Cacatian,S., Tice,C.M., Guo,J., Ishchenko,A., Singh,S.B., Wu,Z., McKeever,B.M., Bukhtiyarov,Y., Johnson,J.A., Doe,C.P., Harrison,R.K., McGeehan,G.M., Dillard,L.W., Baldwin,J.J. and Claremon,D.A. Discovery of VTP-27999, an alkyl amine renin inhibitor with potential for clinical utility ACS Med Chem Lett (2011) 2, 747-751. PubMed Europe PubMed DOI I
Levesque,J.F., Bleasby,K., Chefson,A., Chen,A., Dube,D., Ducharme,Y., Fournier,P.A., Gagne,S., Gallant,M., Grimm,E., Hafey,M., Han,Y., Houle,R., Lacombe,P., Laliberte,S., MacDonald,D., Mackay,B., Papp,R. and Tschirret-Guth,R. Impact of passive permeability and gut efflux transport on the oral bioavailability of novel series of piperidine-based renin inhibitors in rodents Bioorg Med Chem Lett (2011) 21, 5547-5551. PubMed Europe PubMed DOI I
Matter,H., Scheiper,B., Steinhagen,H., Bocskei,Z., Fleury,V. and McCort,G. Structure-based design and optimization of potent renin inhibitors on 5- or 7-azaindole-scaffolds Bioorg Med Chem Lett (2011) 21, 5487-5492. PubMed Europe PubMed DOI I
Scheiper,B., Matter,H., Steinhagen,H., Bocskei,Z., Fleury,V. and McCort,G. Structure-based optimization of potent 4- and 6-azaindole-3-carboxamides as renin inhibitors Bioorg Med Chem Lett (2011) 21, 5480-5486. PubMed Europe PubMed DOI I
Sun,B., Williams,J.S., Pojoga,L., Chamarthi,B., Lasky-Su,J., Raby,B.A., Hopkins,P.N., Jeunemaitre,X., Brown,N.J., Ferri,C. and Williams,G.H. Renin gene polymorphism: its relationship to hypertension, renin levels and vascular responses J Renin Angiotensin Aldosterone Syst (2011) 12, 564-571. PubMed Europe PubMed DOI M
Sund,C., Belda,O., Wiktelius,D., Sahlberg,C., Vrang,L., Sedig,S., Hamelink,E., Henderson,I., Agback,T., Jansson,K., Borkakoti,N., Derbyshire,D., Eneroth,A. and Samuelsson,B. Design and synthesis of potent macrocyclic renin inhibitors Bioorg Med Chem Lett (2011) 21, 358-362. PubMed Europe PubMed DOI I
Thangapandian,S., John,S., Sakkiah,S. and Lee,K.W. Potential virtual lead identification in the discovery of renin inhibitors: application of ligand and structure-based pharmacophore modeling approaches Eur J Med Chem (2011) 46, 2469-2476. PubMed Europe PubMed DOI I
Wu,Y., Shi,C., Sun,X., Wu,X. and Sun,H. Synthesis, biological evaluation and docking studies of octane-carboxamide based renin inhibitors with extended segments toward S3' site of renin Bioorg Med Chem (2011) 19, 4238-4249. PubMed Europe PubMed DOI I
Yuan,J., Simpson,R.D., Zhao,W., Tice,C.M., Xu,Z., Cacatian,S., Jia,L., Flaherty,P.T., Guo,J., Ishchenko,A., Wu,Z., McKeever,B.M., Scott,B.B., Bukhtiyarov,Y., Berbaum,J., Panemangalore,R., Bentley,R., Doe,C.P., Harrison,R.K., McGeehan,G.M., Singh,S.B., Dillard,L.W., Baldwin,J.J. and Claremon,D.A. Biphenyl/diphenyl ether renin inhibitors: filling the S1 pocket of renin via the S3 pocket Bioorg Med Chem Lett (2011) 21, 4836-4843. PubMed Europe PubMed DOI I

2010

Azizi,M. and Menard,J. Review: measurement of plasma renin: a critical review of methodology J Renin Angiotensin Aldosterone Syst (2010) 11, 89-90. PubMed Europe PubMed DOI A V
Bleyer,A.J., Zivna,M., Hulkova,H., Hodanova,K., Vyletal,P., Sikora,J., Zivny,J., Sovova,J., Hart,T.C., Adams,J.N., Elleder,M., Kapp,K., Haws,R., Cornell,L.D., Kmoch,S. and Hart,P.S. Clinical and molecular characterization of a family with a dominant renin gene mutation and response to treatment with fludrocortisone Clin Nephrol (2010) 74, 411-422. PubMed Europe PubMed M
Castrop,H., Hocherl,K., Kurtz,A., Schweda,F., Todorov,V. and Wagner,C. Physiology of kidney renin Physiol Rev (2010) 90, 607-673. PubMed Europe PubMed DOI V
Chen,A., Bayly,C., Bezencon,O., Richard-Bildstein,S., Dube,D., Dube,L., Gagne,S., Gallant,M., Gaudreault,M., Grimm,E., Houle,R., Lacombe,P., Laliberte,S., Levesque,J.F., Liu,S., MacDonald,D., Mackay,B., Martin,D., McKay,D., Powell,D., Remen,L., Soisson,S. and Toulmond,S. Design and optimization of a substituted amino propanamide series of renin inhibitors for the treatment of hypertension Bioorg Med Chem Lett (2010) 20, 2204-2209. PubMed Europe PubMed DOI I
Chen,A., Dube,D., Dube,L., Gagne,S., Gallant,M., Gaudreault,M., Grimm,E., Houle,R., Lacombe,P., Laliberte,S., Liu,S., MacDonald,D., Mackay,B., Martin,D., McKay,D., Powell,D. and Levesque,J.F. Addressing time-dependent CYP 3A4 inhibition observed in a novel series of substituted amino propanamide renin inhibitors, a case study Bioorg Med Chem Lett (2010) 20, 5074-5079. PubMed Europe PubMed DOI I
Corminboeuf,O., Bezencon,O., Remen,L., Grisostomi,C., Richard-Bildstein,S., Bur,D., Prade,L., Strickner,P., Hess,P., Fischli,W., Steiner,B. and Treiber,A. Piperidine-based renin inhibitors: upper chain optimization Bioorg Med Chem Lett (2010) 20, 6291-6296. PubMed Europe PubMed DOI I
Corminboeuf,O., Bezencon,O., Grisostomi,C., Remen,L., Richard-Bildstein,S., Bur,D., Prade,L., Hess,P., Strickner,P., Fischli,W., Steiner,B. and Treiber,A. Design and optimization of new piperidines as renin inhibitors Bioorg Med Chem Lett (2010) 20, 6286-6290. PubMed Europe PubMed DOI I
Gotoh,T., Kikuchi,K.I. and Takahashi,S. Active human renin production using a baculovirus expression vector system: an effective method for preventing excessive proteolytic degradation of recombinant proteins J Chem Eng Jpn (2010) 43, 603-607. DOI E
Gross,K.W., Gomez,R.A. and Sigmund,C.D. Twists and turns in the search for the elusive renin processing enzyme: focus on "Cathepsin B is not the processing enzyme for mouse prorenin" Am J Physiol Regul Integr Comp Physiol (2010) 298, R1209-R1211. PubMed Europe PubMed DOI
Israili,Z.H., Velasco,M. and Bermudez,V. Direct renin inhibitors as antihypertensive agents Am J Ther (2010) 17, 237-254. PubMed Europe PubMed DOI V I
Lacombe,P., Aspiotis,R., Bayly,C., Chen,A., Dube,D., Fortin,R., Gallant,M., Juteau,H., Liu,S., McKay,D., Roy,P. and Wu,T. Identification of a new biaryl scaffold generating potent renin inhibitors Bioorg Med Chem Lett (2010) 20, 5822-5826. PubMed Europe PubMed DOI I
Mercure,C., Lacombe,M.J., Khazaie,K. and Reudelhuber,T.L. Cathepsin B is not the processing enzyme for mouse prorenin Am J Physiol Regul Integr Comp Physiol (2010) 298, R1212-R1216. PubMed Europe PubMed DOI K
Scheiper,B., Matter,H., Steinhagen,H., Stilz,U., Bocskei,Z., Fleury,V. and McCort,G. Discovery and optimization of a new class of potent and non-chiral indole-3-carboxamide-based renin inhibitors Bioorg Med Chem Lett (2010) 20, 6268-6272. PubMed Europe PubMed DOI I
Takahashi,S., Tokiwano,T., Hata,K., Kodama,I., Hokari,M., Suzuki,N., Yoshizawa,Y. and Gotoh,T. The occurrence of renin inhibitor in rice: isolation, identification, and structure-function relationship Biosci Biotechnol Biochem (2010) 74, 1713-1715. PubMed Europe PubMed DOI I
Webb,R.L., Schiering,N., Sedrani,R. and Maibaum,J. Direct renin inhibitors as a new therapy for hypertension J Med Chem (2010) 53, 7490-7520. PubMed Europe PubMed DOI V I
Winiecka,I., Dudkiewicz-Wilczynska,J., Roman,I. and Paruszewski,R. New potential renin inhibitors with dipeptide replacements in the molecule Acta Pol Pharm (2010) 67, 367-374. PubMed Europe PubMed I

2009

Bezencon,O., Bur,D., Weller,T., Richard-Bildstein,S., Remen,L., Sifferlen,T., Corminboeuf,O., Grisostomi,C., Boss,C., Prade,L., Delahaye,S., Treiber,A., Strickner,P., Binkert,C., Hess,P., Steiner,B. and Fischli,W. Design and preparation of potent, nonpeptidic, bioavailable renin inhibitors J Med Chem (2009) 52, 3689-3702. PubMed Europe PubMed DOI I
Kher,V. Renin inhibition - benefit beyond hypertension control J Assoc Physicians India (2009) 57, 518-520. PubMed Europe PubMed I
Nabi,A.H., Biswas,K.B., Nakagawa,T., Ichihara,A., Inagami,T. and Suzuki,F. Prorenin has high affinity multiple binding sites for (pro)renin receptor Biochim Biophys Acta Proteins Proteom (2009) 1794, 1838-1847. PubMed Europe PubMed DOI
Pinto,R. and Gradman,A.H. Direct renin inhibition: an update Curr Hypertens Rep (2009) 11, 456-462. PubMed Europe PubMed DOI V I
Remen,L., Bezencon,O., Richard-Bildstein,S., Bur,D., Prade,L., Corminboeuf,O., Boss,C., Grisostomi,C., Sifferlen,T., Strickner,P., Hess,P., Delahaye,S., Treiber,A., Weller,T., Binkert,C., Steiner,B. and Fischli,W. New classes of potent and bioavailable human renin inhibitors Bioorg Med Chem Lett (2009) 19, 6762-6765. PubMed Europe PubMed DOI I
Riccioni,G., Vitulano,N., D'Orazio,N. and Bellocci,F. Aliskiren, the first approved renin inhibitor: clinical application and safety in the treatment of hypertension Adv Ther (2009) 26, 700-710. PubMed Europe PubMed DOI I
Sanoski,C.A. Aliskiren: an oral direct renin inhibitor for the treatment of hypertension Pharmacotherapy (2009) 29, 193-212. PubMed Europe PubMed DOI I
Tice,C.M., Xu,Z., Yuan,J., Simpson,R.D., Cacatian,S.T., Flaherty,P.T., Zhao,W., Guo,J., Ishchenko,A., Singh,S.B., Wu,Z., Scott,B.B., Bukhtiyarov,Y., Berbaum,J., Mason,J., Panemangalore,R., Cappiello,M.G., Muller,D., Harrison,R.K., McGeehan,G.M., Dillard,L.W., Baldwin,J.J. and Claremon,D.A. Design and optimization of renin inhibitors: orally bioavailable alkyl amines Bioorg Med Chem Lett (2009) 19, 3541-3545. PubMed Europe PubMed DOI I
Yamaguchi,Y., Menear,K., Cohen,N.C., Mah,R., Cumin,F., Schnell,C., Wood,J.M. and Maibaum,J. The P1 N-isopropyl motif bearing hydroxyethylene dipeptide isostere analogues of aliskiren are in vitro potent inhibitors of the human aspartyl protease renin Bioorg Med Chem Lett (2009) 19, 4863-4867. PubMed Europe PubMed DOI I

2008

Dockery,B.K. and Bisognano,J.D. Direct renin inhibition: an analysis of possible benefits Curr Hypertens Rep (2008) 10, 313-318. PubMed Europe PubMed DOI T I
Iwata,H., Nakagawa,T., Yoshioka,Y., Kagei,K., Imada,K., Nakane,C., Fujita,H., Suzuki,F. and Nakamura,Y. The coexistence of Ser84 in renin and His13 in angiotensinogen brings a pH profile of two separate peaks to the reaction of human renin and sheep angiotensinogen Biosci Biotechnol Biochem (2008) 72, 179-185. PubMed Europe PubMed DOI
Jensen,C., Herold,P. and Brunner,H.R. Aliskiren: the first renin inhibitor for clinical treatment Nat Rev Drug Discov (2008) 7, 399-410. PubMed Europe PubMed DOI I
Major,T.C., Olszewski,B., Rosebury,W., Okerberg,C., Carlson,T., Ostroski,R., Schroeder,R., Kowala,M.C. and Leadley,R. A nonpeptide, piperidine renin inhibitor provides renal and cardiac protection in double-transgenic mice expressing human renin and angiotensinogen genes Cardiovasc Drugs Ther (2008) 22, 469-478. PubMed Europe PubMed DOI I
Schefe,J.H., Neumann,C., Goebel,M., Danser,J., Kirsch,S., Gust,R., Kintscher,U., Unger,T. and Funke-Kaiser,H. Prorenin engages the (pro)renin receptor like renin and both ligand activities are unopposed by aliskiren J Hypertens (2008) 26, 1787-1794. PubMed Europe PubMed DOI I
Takahashi,S., Hori,K., Shinbo,M., Hiwatashi,K., Gotoh,T. and Yamada,S. Isolation of human renin inhibitor from soybean: soyasaponin I is the novel human renin inhibitor in soybean Biosci Biotechnol Biochem (2008) 72, 3232-3236. PubMed Europe PubMed DOI
Uddin,M.N., Nabi,A.H., Nakagawa,T., Ichihara,A., Inagami,T. and Suzuki,F. Non-proteolytic activation of prorenin: activation by (pro)renin receptor and its inhibition by a prorenin prosegment, "decoy peptide" Front Biosci (2008) 13, 745-753. PubMed Europe PubMed DOI V
Wu,Z., Cappiello,M.G., Scott,B.B., Bukhtiyarov,Y. and McGeehan,G.M. Purification and characterization of recombinant human renin for X-Ray crystallization studies BMC Biochem (2008) 9, 19-19. PubMed Europe PubMed DOI PMC EPMC E

2007

Achard,V., Boullu-Ciocca,S., Desbriere,R., Nguyen,G. and Grino,M. Renin receptor expression in human adipose tissue Am J Physiol Regul Integr Comp Physiol (2007) 292, R274-R282. PubMed Europe PubMed DOI
Brown,M.J. Renin: friend or foe? Heart (2007) 93, 1026-1033. PubMed Europe PubMed DOI V
Bukhtiyarov,Y., Zecher,M., Panemangalore,R., Wu,Z., Bruno,J.G., Yuan,J., Xu,Z., Dillard,L.W., McGeehan,G.M., Harrison,R.K. and Scott,B.B. Cloning, characterization and site-directed mutagenesis of canine renin J Biochem (2007) 142, 671-680. PubMed Europe PubMed DOI
Dechend,R., Shagdarsuren,E., Gratze,P., Fiebeler,A., Pilz,B., Meiners,S., Derer,W., Feldman,D.L., Webb,R. and Muller,D.N. Low-dose renin inhibitor and low-dose AT(1)-receptor blocker therapy ameliorate target-organ damage in rats harbouring human renin and angiotensinogen genes J Renin Angiotensin Aldosterone Syst (2007) 8, 81-84. PubMed Europe PubMed DOI I
Goschke,R., Stutz,S., Rasetti,V., Cohen,N.C., Rahuel,J., Rigollier,P., Baum,H.P., Forgiarini,P., Schnell,C.R., Wagner,T., Gruetter,M.G., Fuhrer,W., Schilling,W., Cumin,F., Wood,J.M. and Maibaum,J. Novel 2,7-dialkyl-substituted 5(S)-amino-4(S)-hydroxy-8-phenyl-octanecarboxamide transition state peptidomimetics are potent and orally active inhibitors of human renin J Med Chem (2007) 50, 4818-4831. PubMed Europe PubMed DOI I
Holsworth,D.D., Jalaie,M., Belliotti,T., Cai,C., Collard,W., Ferreira,S., Powell,N.A., Stier,M., Zhang,E., McConnell,P., Mochalkin,I., Ryan,M.J., Bryant,J., Li,T., Kasani,A., Subedi,R., Maiti,S.N. and Edmunds,J.J. Discovery of 6-ethyl-2,4-diaminopyrimidine-based small molecule renin inhibitors Bioorg Med Chem Lett (2007) 17, 3575-3580. PubMed Europe PubMed DOI I
Konoshita,T., Fuchs,S., Makino,Y., Wakahara,S. and Miyamori,I. A proximal direct repeat motif characterized as a negative regulatory element in the human renin gene J Cell Biochem (2007) 102, 1043-1050. PubMed Europe PubMed DOI
Leibovitz,E. and Schiffrin,E.L. Novel drugs targeting hypertension: renin inhibitors and beyond J Cardiovasc Pharmacol (2007) 50, 3-8. PubMed Europe PubMed DOI V I
Li,Y.C. Inhibition of renin: an updated review of the development of renin inhibitors Curr Opin Investig Drugs (2007) 8, 750-757. PubMed Europe PubMed V I
Maas,M.H., Cransberg,K., van Grotel,M., Pieters,R. and Heuvel-Eibrink,M.M. Renin-induced hypertension in Wilms tumor patients Pediatr Blood Cancer (2007) 48, 500-503. PubMed Europe PubMed DOI
Maibaum,J., Stutz,S., Goschke,R., Rigollier,P., Yamaguchi,Y., Cumin,F., Rahuel,J., Baum,H.P., Cohen,N.C., Schnell,C.R., Fuhrer,W., Gruetter,M.G., Schilling,W. and Wood,J.M. Structural modification of the P2' position of 2,7-dialkyl-substituted 5(S)-amino-4(S)-hydroxy-8-phenyl-octanecarboxamides: the discovery of aliskiren, a potent nonpeptide human renin inhibitor active after once daily dosing in marmosets J Med Chem (2007) 50, 4832-4844. PubMed Europe PubMed DOI I
Moore,N., Dicker,P., O'Brien,J.K., Stojanovic,M., Conroy,R.M., Treumann,A., O'Brien,E.T., Fitzgerald,D., Shields,D. and Stanton,A.V. Renin gene polymorphisms and haplotypes, blood pressure, and responses to renin-angiotensin system inhibition Hypertension (2007) 50, 340-347. PubMed Europe PubMed DOI M
Nakagawa,T., Nishiuchi,K., Akaki,J., Iwata,H., Satou,R., Suzuki,F. and Nakamura,Y. Efficient production of recombinant human (pro)renin utilizing a decahistidine tag attached at the C-terminus Biosci Biotechnol Biochem (2007) 71, 256-260. PubMed Europe PubMed DOI E
Nakagawa,T., Akaki,J., Satou,R., Takaya,M., Iwata,H., Katsurada,A., Nishiuchi,K., Ohmura,Y., Suzuki,F. and Nakamura,Y. The His-Pro-Phe motif of angiotensinogen is a crucial determinant of the substrate specificity of renin Biol Chem (2007) 388, 237-246. PubMed Europe PubMed DOI P
Nurun,N.A., Uddin,N.M., Nakagawa,T., Iwata,H., Ichihara,A., Inagami,T. and Suzuki,F. Role of "handle" region of prorenin prosegment in the non-proteolytic activation of prorenin by binding to membrane anchored (pro)renin receptor Front Biosci (2007) 12, 4810-4817. PubMed Europe PubMed DOI
Pool,J.L. Direct renin inhibition: focus on aliskiren J Manag Care Pharm (2007) 13, 21-33. PubMed Europe PubMed I
Powell,N.A., Ciske,F.L., Cai,C., Holsworth,D.D., Mennen,K., Van Huis,C.A., Jalaie,M., Day,J., Mastronardi,M., McConnell,P., Mochalkin,I., Zhang,E., Ryan,M.J., Bryant,J., Collard,W., Ferreira,S., Gu,C., Collins,R. and Edmunds,J.J. Rational design of 6-(2,4-diaminopyrimidinyl)-1,4-benzoxazin-3-ones as small molecule renin inhibitors Bioorg Med Chem (2007) 15, 5912-5949. PubMed Europe PubMed DOI I
Ram,C.V. Direct renin inhibitors: a new approach to antihypertensive drug treatment J Clin Hypertens (Greenwich) (2007) 9, 615-621. PubMed Europe PubMed DOI
Reid,A.C., Silver,R.B. and Levi,R. Renin: at the heart of the mast cell Immunol Rev (2007) 217, 123-140. PubMed Europe PubMed DOI
Sarver,R.W., Peevers,J., Cody,W.L., Ciske,F.L., Dyer,J., Emerson,S.D., Hagadorn,J.C., Holsworth,D.D., Jalaie,M., Kaufman,M., Mastronardi,M., McConnell,P., Powell,N.A., Quin,J., III, Van Huis,C.A., Zhang,E. and Mochalkin,I. Binding thermodynamics of substituted diaminopyrimidine renin inhibitors Anal Biochem (2007) 360, 30-40. PubMed Europe PubMed DOI I
Schweda,F., Friis,U., Wagner,C., Skott,O. and Kurtz,A. Renin release Physiology (Bethesda) (2007) 22, 310-319. PubMed Europe PubMed DOI V
Suzuki,F. Spotlight on renin: nonproteolytic activation of prorenin by the (pro)renin receptor is blocked by decoy peptide J Renin Angiotensin Aldosterone Syst (2007) 8, 101-103. PubMed Europe PubMed DOI
Takahashi,S., Hata,K., Kikuchi,K. and Gotoh,T. High-level expression of recombinant active human renin in Sf-9 cells: rapid purification and characterization Biosci Biotechnol Biochem (2007) 71, 2610-2613. PubMed Europe PubMed DOI E
Van Tassell,B.W. and Munger,M.A. Aliskiren for renin inhibition: a new class of antihypertensives Ann Pharmacother (2007) 41, 456-464. PubMed Europe PubMed DOI I

2006

Azizi,M. Renin inhibition Curr Opin Nephrol Hypertens (2006) 15, 505-510. PubMed Europe PubMed DOI V I
[YEAR:19-12-2006]Bernstein,K.E. Views of the renin-angiotensin system: brilling, mimsy, and slithy tove Hypertension (19-12-2006) 47, 509-514. PubMed Europe PubMed DOI V
Burckle,C. and Bader,M. Prorenin and its ancient receptor Hypertension (2006) 48, 549-551. PubMed Europe PubMed DOI
Ferro,A., Gilbert,R. and Krum,H. Importance of renin in blood pressure regulation and therapeutic potential of renin inhibition Int J Clin Pract (2006) 60, 577-581. PubMed Europe PubMed DOI I
[YEAR:7-2-2006]Holsworth,D.D., Cai,C., Cheng,X.M., Cody,W.L., Downing,D.M., Erasga,N., Lee,C., Powell,N.A., Edmunds,J.J., Stier,M., Jalaie,M., Zhang,E., McConnell,P., Ryan,M.J., Bryant,J., Li,T., Kasani,A., Hall,E., Subedi,R., Rahim,M. and Maiti,S. Ketopiperazine-based renin inhibitors: optimization of the "C" ring Bioorg Med Chem Lett (7-2-2006) 16, 2500-2504. PubMed Europe PubMed DOI I
Kalus,J.S. Aliskiren: a novel oral renin inhibitor for the treatment of hypertension Formulary (2006) 41, 631-638. I
Kushiro,T., Itakura,H., Abo,Y., Gotou,H., Terao,S. and Keefe,D.L. Aliskiren, a novel oral renin inhibitor, provides dose-dependent efficacy and placebo-like tolerability in Japanese patients with hypertension Hypertens Res (2006) 29, 997-1005. PubMed Europe PubMed DOI I
Le,T.H. and Coffman,T.M. A new cardiac MASTer switch for the renin-angiotensin system J Clin Invest (2006) 116, 866-869. PubMed Europe PubMed DOI PMC EPMC
Luft,F.C. Achieving the goal of optimised renin system suppression: preclinical experience with a direct renin inhibitor J Renin Angiotensin Aldosterone Syst (2006) 7 Suppl 2, S12-S15. I
Muller,D.N. and Luft,F.C. Direct renin inhibition with aliskiren in hypertension and target organ damage Clin J Am Soc Nephrol (2006) 1, 221-228. PubMed Europe PubMed DOI I
Nabi,A.H., Kageshima,A., Uddin,M.N., Nakagawa,T., Park,E.Y. and Suzuki,F. Binding properties of rat prorenin and renin to the recombinant rat renin/prorenin receptor prepared by a baculovirus expression system Int J Mol Med (2006) 18, 483-488. PubMed Europe PubMed
Scott,B.B., McGeehan,G.M. and Harrison,R.K. Development of inhibitors of the aspartyl protease renin for the treatment of hypertension Curr Protein Pept Sci (2006) 7, 241-254. PubMed Europe PubMed DOI V I
Staessen,J.A., Li,Y. and Richart,T. Oral renin inhibitors Lancet (2006) 368, 1449-1456. PubMed Europe PubMed DOI I
Takahashi,S., Ogasawara,H., Watanabe,T., Kumagai,M., Inoue,H. and Hori,K. Refolding and activation of human prorenin expressed in Escherichia coli: application of recombinant human renin for inhibitor screening Biosci Biotechnol Biochem (2006) 70, 2913-2918. PubMed Europe PubMed DOI E
Tice,C.M. Renin inhibitors Annu Rep Med Chem (2006) 41, 155-167. DOI V I

2005

Fisher,N.D. and Hollenberg,N.K. Renin inhibition: what are the therapeutic opportunities? J Am Soc Nephrol (2005) 16, 592-599. PubMed Europe PubMed DOI V
[YEAR:1-3-2005]Gradman,A.H., Schmieder,R.E., Lins,R.L., Nussberger,J., Chiang,Y. and Bedigian,M.P. Aliskiren, a novel orally effective renin inhibitor, provides dose-dependent antihypertensive efficacy and placebo-like tolerability in hypertensive patients Circulation (1-3-2005) 111, 1012-1018. PubMed Europe PubMed DOI I
[YEAR:1-4-2005]Holsworth,D.D., Powell,N.A., Downing,D.M., Cai,C., Cody,W.L., Ryan,J.M., Ostroski,R., Jalaie,M., Bryant,J.W. and Edmunds,J.J. Discovery of novel non-peptidic ketopiperazine-based renin inhibitors Bioorg Med Chem (1-4-2005) 13, 2657-2664. PubMed Europe PubMed DOI I
Leckie,B.J. Targeting the renin-angiotensin system: what's new? Curr Med Chem Cardiovasc Hematol Agents (2005) 3, 23-32. PubMed Europe PubMed DOI V
Nabi,A.H., Uddin,M.N., Nakagawa,T., Orihashi,T., Ebihara,A., Iwasawa,A., Nakamura,Y. and Suzuki,F. Roles of His9 (P2 subsite) and His13 (P3' subsite) in angiotensinogen for catalytic reaction of renin Int J Mol Med (2005) 16, 103-107. PubMed Europe PubMed
[YEAR:15-11-2005]Pan,L. and Gross,K.W. Transcriptional regulation of renin: an update Hypertension (15-11-2005) 45, 3-8. PubMed Europe PubMed DOI V
Paruszewski,R., Jaworski,P., Bodnar,M., Dudkiewicz-Wilczynska,J. and Roman,I. New renin inhibitors containing pseudodipeptidic units in P3-P2 and P1-P1' positions Chem Pharm Bull (Tokyo) (2005) 53, 1305-1309. PubMed Europe PubMed DOI I
[YEAR:2-5-2005]Powell,N.A., Clay,E.H., Holsworth,D.D., Bryant,J.W., Ryan,M.J., Jalaie,M., Zhang,E. and Edmunds,J.J. Equipotent activity in both enantiomers of a series of ketopiperazine-based renin inhibitors Bioorg Med Chem Lett (2-5-2005) 15, 2371-2374. PubMed Europe PubMed DOI I
[YEAR:2-9-2005]Powell,N.A., Clay,E.H., Holsworth,D.D., Bryant,J.W., Ryan,M.J., Jalaie,M. and Edmunds,J.J. Benzyl ether structure-activity relationships in a series of ketopiperazine-based renin inhibitors Bioorg Med Chem Lett (2-9-2005) 15, 4713-4716. PubMed Europe PubMed DOI I
[YEAR:3-3-2005]Ramser,J., Abidi,F.E., Burckle,C.A., Lenski,C., Toriello,H., Wen,G., Lubs,H.A., Engert,S., Stevenson,R.E., Meindl,A., Schwartz,C.E. and Nguyen,G. A unique exonic splice enhancer mutation in a family with X-linked mental retardation and epilepsy points to a novel role of the renin receptor Hum Mol Genet (3-3-2005) 14, 1019-1027. PubMed Europe PubMed DOI
[YEAR:2-5-2005]Van Epps,H.L. Harry Goldblatt and the discovery of renin J Exp Med (2-5-2005) 201, 1351-1351. PubMed Europe PubMed PMC EPMC
Wang,X., Sun,Z. and Cade,R. Prolonged attenuation of cold-induced hypertension by adenoviral delivery of renin antisense Kidney Int (2005) 68, 680-687. PubMed Europe PubMed DOI
Wood,J.M., Schnell,C.R., Cumin,F., Menard,J. and Webb,R.L. Aliskiren, a novel, orally effective renin inhibitor, lowers blood pressure in marmosets and spontaneously hypertensive rats J Hypertens (2005) 23, 417-426. PubMed Europe PubMed DOI I

2004

Hansen,P.B., Yang,T., Huang,Y., Mizel,D., Briggs,J. and Schnermann,J. Plasma renin in mice with one or two renin genes Acta Physiol Scand (2004) 181, 431-437. PubMed Europe PubMed DOI
Ichihara,A., Hayashi,M., Kaneshiro,Y., Suzuki,F., Nakagawa,T., Tada,Y., Koura,Y., Nishiyama,A., Okada,H., Uddin,M.N., Nabi,A.H., Ishida,Y., Inagami,T. and Saruta,T. Inhibition of diabetic nephropathy by a decoy peptide corresponding to the "handle" region for nonproteolytic activation of prorenin J Clin Invest (2004) 114, 1128-1135. PubMed Europe PubMed DOI PMC EPMC
[YEAR:25-11-2004]Liang,P., Jones,C.A., Bisgrove,B.W., Song,L., Glenn,S.T., Yost,H.J. and Gross,K.W. Genomic characterization and expression analysis of the first nonmammalian renin genes from zebrafish and pufferfish Physiol Genomics (25-11-2004) 16, 314-322. PubMed Europe PubMed DOI
Nguyen,G. and Burckle,C.A. [The (pro)renin receptor: biology and functional significance] Bull Acad Natl Med (2004) 188, 621-628. PubMed Europe PubMed
Nguyen,G., Burckle,C.A. and Sraer,J.D. Renin/prorenin-receptor biochemistry and functional significance Curr Hypertens Rep (2004) 6, 129-132. PubMed Europe PubMed
[YEAR:3-2-2004]Pan,L., Jones,C.A., Glenn,S.T. and Gross,K.W. Identification of a novel region in the proximal promoter of the mouse renin gene critical for expression Am J Physiol Renal Physiol (3-2-2004) 286, F1107-F1115. PubMed Europe PubMed DOI
[YEAR:2-7-2004]Paschalidou,K., Neumann,U., Gerhartz,B. and Tzougraki,C. Highly sensitive intramolecularly quenched fluorogenic substrates for renin based on the combination of L-2-amino-3-(7-methoxy-4-coumaryl)propionic acid with 2,4-dinitrophenyl groups at various positions Biochem J (2-7-2004) 382, 1031-1038. PubMed Europe PubMed DOI PMC EPMC A
[YEAR:14-9-2004]Silver,R.B., Reid,A.C., Mackins,C.J., Askwith,T., Schaefer,U., Herzlinger,D. and Levi,R. Mast cells: a unique source of renin Proc Natl Acad Sci U S A (14-9-2004) 101, 13607-13612. PubMed Europe PubMed DOI PMC EPMC
Suzuki,F., Murakami,K., Nakamura,Y. and Inagami,T. Renin [ISSN:0-12-079610-4] (2004) 2, 54-61. V

2003

Lavoie,J.L. and Sigmund,C.D. Minireview: overview of the renin-angiotensin system - an endocrine and paracrine system Endocrinology (2003) 144, 2179-2183. PubMed Europe PubMed DOI V
Maibaum,J. and Feldman,D.L. Renin inhibitors as novel treatments for cardiovascular disease Expert Opin Ther Pat (2003) 13, 589-603. I
Morris,B.J. Renin: from 'pro' to promoter Bioessays (2003) 25, 520-527. PubMed Europe PubMed DOI
Persson,P.B., Skalweit,A., Mrowka,R. and Thiele,B.J. Control of renin synthesis Am J Physiol Regul Integr Comp Physiol (2003) 285, R491-R497. PubMed Europe PubMed DOI
[YEAR:1-11-2003]Persson,P.B. Renin: origin, secretion and synthesis J Physiol (1-11-2003) 552, 667-671. PubMed Europe PubMed DOI PMC EPMC
Pursell,R.N. and Quinlan,P.M. Secondary hypertension due to a renin-producing teratoma Am J Hypertens (2003) 16, 592-595. PubMed Europe PubMed DOI
[YEAR:20-6-2003]Suzuki,F., Hayakawa,M., Nakagawa,T., Nasir,U.M., Ebihara,A., Iwasawa,A., Ishida,Y., Nakamura,Y. and Murakami,K. Human prorenin has "gate and handle" regions for its non-proteolytic activation J Biol Chem (20-6-2003) 278, 22217-22222. PubMed Europe PubMed DOI
[YEAR:5-9-2003]Wood,J.M., Maibaum,J., Rahuel,J., Grutter,M.G., Cohen,N.C., Rasetti,V., Ruger,H., Goschke,R., Stutz,S., Fuhrer,W., Schilling,W., Rigollier,P., Yamaguchi,Y., Cumin,F., Baum,H.P., Schnell,C.R., Herold,P., Mah,R., Jensen,C., O'Brien,E., Stanton,A. and Bedigian,M.P. Structure-based design of aliskiren, a novel orally effective renin inhibitor Biochem Biophys Res Commun (5-9-2003) 308, 698-705. PubMed Europe PubMed DOI S I

2002

[YEAR:11-6-2002]Caron,K.M., James,L.R., Kim,H.S., Morham,S.G., Sequeira Lopez,M.L., Gomez,R.A., Reudelhuber,T.L. and Smithies,O. A genetically clamped renin transgene for the induction of hypertension Proc Natl Acad Sci U S A (11-6-2002) 99, 8248-8252. PubMed Europe PubMed DOI PMC EPMC
Fuchs,S., Germain,S., Philippe,J., Corvol,P. and Pinet,F. Expression of renin in large arteries outside the kidney revealed by human renin promoter/LacZ transgenic mouse Am J Pathol (2002) 161, 717-725. PubMed Europe PubMed DOI PMC EPMC
Prescott,G., Silversides,D.W. and Reudelhuber,T.L. Tissue activity of circulating prorenin Am J Hypertens (2002) 15, 280-285. PubMed Europe PubMed DOI
Yabuki,A., Suzuki,S., Matsumoto,M., Taniguchi,K. and Nishinakagawa,H. A simple method for the specific detection of Ren-1 renin Kidney Int (2002) 62, 2294-2299. PubMed Europe PubMed DOI

2001

Leckie,B.J. Polymorphisms of the renin gene promoter in spontaneously hypertensive and Wistar-Kyoto rats Clin Exp Pharmacol Physiol (2001) 28, 60-63. PubMed Europe PubMed DOI M
Saris,J.J., Derkx,F.H., De Bruin,R.J., Dekkers,D.H., Lamers,J.M., Saxena,P.R., Schalekamp,M.A. and Danser,A.H.J. High-affinity prorenin binding to cardiac man-6-P/IGF-II receptors precedes proteolytic activation to renin Am J Physiol Heart Circ Physiol (2001) 280, H1706-H1715. PubMed Europe PubMed
[YEAR:2-2-2001]Shi,Q., Gross,K.W. and Sigmund,C.D. Retinoic acid-mediated activation of the mouse renin enhancer J Biol Chem (2-2-2001) 276, 3597-3603. PubMed Europe PubMed DOI
van den Eijnden,M.M., Saris,J.J., De Bruin,R.J., de Wit,E., Sluiter,W., Reudelhuber,T.L., Schalekamp,M.A., Derkx,F.H. and Danser,A.H. Prorenin accumulation and activation in human endothelial cells: importance of mannose 6-phosphate receptors Arterioscler Thromb Vasc Biol (2001) 21, 911-916. PubMed Europe PubMed

2000

Rahuel,J., Rasetti,V., Maibaum,J., Rueger,H., Goschke,R., Cohen,N.C., Stutz,S., Cumin,F., Fuhrer,W., Wood,J.M. and Grutter,M.G. Structure-based drug design: the discovery of novel nonpeptide orally active inhibitors of human renin Chem Biol (2000) 7, 493-504. PubMed Europe PubMed DOI I
[YEAR:29-6-2000]Sinn,P.L. and Sigmund,C.D. Identification of three human renin mRNA isoforms from alternative tissue-specific transcriptional initiation Physiol Genomics (29-6-2000) 3, 25-31. PubMed Europe PubMed
[YEAR:19-1-2000]Suzuki,F., Nakagawa,T., Kakidachi,H., Murakami,K., Inagami,T. and Nakamura,Y. The dominant role of the prosegment of prorenin in determining the rate of activation by acid or trypsin: Studies with molecular chimeras Biochem Biophys Res Commun (19-1-2000) 267, 577-580. PubMed Europe PubMed DOI
Zimmerman,B.G. Greater blood pressure-lowering effect of the renin inhibitor EMD 58265 than an angiotensin-converting enzyme inhibitor in two-kidney one-clip Goldblatt rabbit Clin Exp Pharmacol Physiol (2000) 27, 370-377. PubMed Europe PubMed DOI I

1999

Admiraal,P.J., van Kesteren,C.A., Danser,A.H., Derkx,F.H., Sluiter,W. and Schalekamp,M.A. Uptake and proteolytic activation of prorenin by cultured human endothelial cells J Hypertens (1999) 17, 621-629. PubMed Europe PubMed DOI
Frossard,P.M., Lestringant,G.G., Malloy,M.J. and Kane,J.P. Human renin gene BglI dimorphism associated with hypertension in two independent populations Clin Genet (1999) 56, 428-433. PubMed Europe PubMed DOI
Germain,S., Bonnet,F., Fuchs,S., Philippe,J., Corvol,P. and Pinet,F. Dissection of silencer elements in first intron controlling the human renin gene J Hypertens (1999) 17, 899-905. PubMed Europe PubMed DOI
[YEAR:22-1-1999]Jutras,I. and Reudelhuber,T.L. Prorenin processing by cathepsin B in vitro and in transfected cells FEBS Lett (22-1-1999) 443, 48-52. PubMed Europe PubMed DOI
Nasir,U.M., Suzuki,F., Nagai,T., Nakagawa,T. and Nakamura,Y. Tyrosine-83 of human renin contributes to biphasic pH dependence of the renin-angiotensinogen reaction Biosci Biotechnol Biochem (1999) 63, 1143-1145. PubMed Europe PubMed
Oefner,C., Binggeli,A., Breu,V., Bur,D., Clozel,J.P., D'arcy,A., Dorn,A., Fischli,W., Gruninger,F., Guller,R., Hirth,G., Marki,H., Mathews,S., ller,M., Ridley,R.G., Stadler,H., Vieira,E., Wilhelm,M., Winkler,F. and Wostl,W. Renin inhibition by substituted piperidines: a novel paradigm for the inhibition of monomeric aspartic proteinases? Chem Biol (1999) 6, 127-131. PubMed Europe PubMed DOI
Valdenaire,O., Breu,V., Giller,T., Bur,D. and Fischli,W. Cloning and characterization of marmoset renin: comparison with human renin J Cardiovasc Pharmacol (1999) 34, 893-897. PubMed Europe PubMed DOI

1998

[YEAR:10-11-1998]Deinum,J., Derkx,F.H. and Schalekamp,M.A. Probing epitopes on human prorenin during its proteolytic and non-proteolytic activation Biochim Biophys Acta (10-11-1998) 1388, 386-396. PubMed Europe PubMed DOI I
[YEAR:25-9-1998]Germain,S., Bonnet,F., Philippe,J., Fuchs,S., Corvol,P. and Pinet,F. A novel distal enhancer confers chorionic expression on the human renin gene J Biol Chem (25-9-1998) 273, 25292-25300. PubMed Europe PubMed DOI
Inagami,T. A memorial to Robert Tiegerstedt: the centennial of renin discovery Hypertension (1998) 32, 953-957. PubMed Europe PubMed
Kikkawa,Y., Yamanaka,N., Tada,J., Kanamori,N., Tsumura,K. and Hosoi,K. Prorenin processing and restricted endoproteolysis by mouse tissue kallikrein family enzymes (MK1, MK9, MK13, and MK22) Biochim Biophys Acta (1998) 1382, 55-64. PubMed Europe PubMed DOI

1997

Salzet,M. and Stefano,G. A renin-like enzyme in the leech Theromyzon tessulatum Mol Cell Endocrinol (1997) 131, 1-8. PubMed Europe PubMed DOI
Sueiras-Diaz,J., Jones,D.M., Szelke,M., Leckie,B.J., Beattie,S.R., Beattie,C. and Morton,J.J. Potent in vivo inhibitors of rat renin: analogues of human and rat angiotensinogen sequences containing different classes of pseudodipeptides at the scissile site J Pept Res (1997) 50, 239-247. PubMed Europe PubMed I
Tokarski,J.S. and Hopfinger,A.J. Prediction of ligand-receptor binding thermodynamics by free energy force field (FEFF) 3D-QSAR analysis: application to a set of peptidometic renin inhibitors J Chem Inf Comput Sci (1997) 37, 792-811. PubMed Europe PubMed I

1996

De Vito,E., Martinez de Melian,E.R. and Guardia,D.C. Activation of renal renin by a protein plasma fraction: a novel enzymatic mechanism Comp Biochem Physiol B Biochem Mol Biol (1996) 113, 433-438. PubMed Europe PubMed DOI
LaPlante,S.R., Tong,L., Aubry,N., Pav,S., Jung,G. and Anderson,P.C. Several polyhydroxymonoamide renin inhibitors assume similar conformations in the unbound and renin-bound states Int J Pept Protein Res (1996) 48, 401-410. PubMed Europe PubMed I
Mathews,S., Dobeli,H., Pruschy,M., Bosser,R., D'arcy,A., Oefner,C., Zulauf,M., Gentz,R., Breu,V., Matile,H., Schlaeger,J. and Fischli,W. Recombinant human renin produced in different expression systems: biochemical properties and 3D structure Protein Expr Purif (1996) 7, 81-91. PubMed Europe PubMed DOI E S I

1995

Aguilar,C.F., Dhanaraj,V., Guruprasad,K., Dealwis,C., Badasso,M., Cooper,J.B., Wood,S.P. and Blundell,T.L. Comparisons of the three-dimensional structures, specificities and glycosylation of renins, yeast proteinase A and cathepsin D Adv Exp Med Biol (1995) 362, 155-166. PubMed Europe PubMed
Menard,J., Boger,R.S., Moyse,D.M., Guyene,T.T., Glassman,H.N. and Kleinert,H.D. Dose-dependent effects of the renin inhibitor zankiren HCl after a single oral dose in mildly sodium-depleted normotensive subjects Circulation (1995) 91, 330-338. PubMed Europe PubMed I
Morris,B.J. Some physiological outcomes of renin gene studies Clin Exp Pharmacol Physiol (1995) 22, 966-975. PubMed Europe PubMed
Tong,L., Pav,S., Lamarre,D., Pilote,L., Laplante,S., Anderson,P.C. and Jung,G. High resolution crystal structures of recombinant human renin in complex with polyhydroxymonoamide inhibitors J Mol Biol (1995) 250, 211-222. PubMed Europe PubMed DOI S I
Tong,L., Pav,S., Lamarre,D., Simoneau,B., Lavallee,P. and Jung,G. Crystallographic studies on the binding modes of P2-P3 butanediamide renin inhibitors J Biol Chem (1995) 270, 29520-29524. PubMed Europe PubMed DOI S I

1994

Hatae,T., Takimoto,E., Murakami,K. and Fukamizu,A. Comparative studies on species-specific reactivity between renin and angiotensinogen Mol Cell Biochem (1994) 131, 43-47. PubMed Europe PubMed P
Mangiapane,M.L., MacAndrew,J.T., Ellery,S.S., Smith,A.H., Purcell,I.M., Kleinman,E.F., Holt,W.F. and Murphy,W.R. CP-71,362: a pentapeptide renin inhibitor selective for the canine enzyme Clin Exp Hypertens (1994) 16, 507-533. PubMed Europe PubMed DOI I
Shinagawa,T., Nakayama,K., Uchiyama,Y., Kominami,E., Doi,Y., Hashiba,K., Yano,K., Hseu,W.A. and Murakami,K. Role of cathepsin B as prorenin processing enzyme in human kidney Hypertens Res (1994) 18, 131-136.
[YEAR:6-12-1994]Wang,W. and Liang,T.C. Substrate specificity of porcine renin: P1', P1, and P3 residues of renin substrates are crucial for activity Biochemistry (6-12-1994) 33, 14636-14641. PubMed Europe PubMed DOI P
Wood,J.M., Cumin,F. and Maibaum,J. Pharmacology of renin inhibitors and their application to the treatment of hypertension Pharmacol Ther (1994) 61, 325-344. PubMed Europe PubMed DOI I

1993

Rao,C., Scarborough,P.E., Lowther,W.T., Kay,J., Batley,B., Rapundalo,S., Klutchko,S., Taylor,M.D. and Dunn,B.M. Structure-function database for active site binding to the aspartic proteinases Adv Exp Med Biol (1993) 306, 143-147.

1992

[YEAR:15-11-1992]Derkx,F.H., Deinum,J., Lipovski,M., Verhaar,M., Fischli,W. and Schalekamp,M.A. Nonproteolytic "activation" of prorenin by active site-directed renin inhibitors as demonstrated by renin-specific monoclonal antibody J Biol Chem (15-11-1992) 267, 22837-22842. PubMed Europe PubMed
Dhanaraj,V., Dealwis,C.G., Frazao,C., Badasso,M., Sibanda,B.L., Tickle,I.J., Cooper,J.B., Driessen,H.P.C., Newman,M., Aguilar,C., Wood,S.P., Blundell,T.L., Hobart,P.M., Geoghegan,K.F., Ammirati,M.J., Danley,D.E., O'Connor,B.A. and Hoover,D.J. X-ray analyses of peptide-inhibitor complexes define the structural basis of specificity for human and mouse renins Nature (1992) 357, 466-472. PubMed Europe PubMed DOI S
[YEAR:15-8-1992]Ganten,D., Wagner,J., Zeh,K., Bader,M., Michel,J.B., Paul,M., Zimmermann,F., Ruf,P., Hilgenfeldt,U. and Ganten,U. Species specificity of renin kinetics in transgenic rats harboring the human renin and angiotensinogen genes Proc Natl Acad Sci U S A (15-8-1992) 89, 7806-7810. PubMed Europe PubMed PMC EPMC I
Murakami,E., Kokubu,T., Ii,Y., Hiwada,K., Muramatsu,S., Takahagi,H. and Salmon,P.F. Effects of repeated oral administration of renin inhibitor ES-8891 on the renin-angiotensin system in human subjects Hypertens Res (1992) 15, 41-44. DOI I
[YEAR:15-5-1992]Oliveira,M.C., Hirata,I.Y., Chagas,J.R., Boschcov,P., Gomes,R.A., Figueiredo,A.F. and Juliano,L. Intramolecularly quenched fluorogenic peptide substrates for human renin Anal Biochem (15-5-1992) 203, 39-46. PubMed Europe PubMed DOI
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Yamauchi,T., Suzuki,F., Takahashi,A., Tsutsumi,I., Hori,H., Watanabe,T., Ishizuka,Y., Nakamura,Y. and Murakami,K. Expression of rat renin in mammalian cells and its purification Clin Exp Hypertens A (1992) 14, 377-392. PubMed Europe PubMed E

1991

Doi,M., In,Y., Inoue,M., Ishida,T., Iizuka,K., Akahane,K., Harada,H., Umeyama,H. and Kiso,Y. Conformational study of a potent human renin inhibitor: X-ray crystal structure of isopropyl (2R,3S)-4-cyclohexyl- 2- hydroxy-3-{N-[(2R)-2-morpholinocarbonylmethyl-3-(1- naphthyl)propionyl]-L-histidylamino}butyrate (KRI-1314), a pentapeptide analogue with amino acid sequence corresponding to the cleavage site of angiotensinogen Chem Soc J [Perkin 1] (1991) 1991, 1153-1158. S I
Fischli,W., Clozel,J.P., el Amrani,K., Wostl,W., Neidhart,W., Stadler,H. and Branca,Q. Ro 42-5892 is a potent orally active renin inhibitor in primates Hypertension (1991) 18, 22-31. PubMed Europe PubMed I
Ido,E., Han,H.P., Kezdy,F.J. and Tang,J. Kinetic studies of human immunodeficiency virus type 1 protease and its active-site hydrogen bond mutant A28S J Biol Chem (1991) 266, 24359-24366. PubMed Europe PubMed
Ishizuka,Y., Shoda,A., Yoshida,S., Kawamura,Y., Haraguchi,K. and Murakami,K. Isolation and characterization of recombinant human prorenin in Chinese hamster ovary cells J Biochem (1991) 109, 30-35. PubMed Europe PubMed
[YEAR:15-4-1991]Kim,S., Hosoi,M., Kikuchi,N. and Yamamoto,K. Amino-terminal amino acid sequence and heterogeneity in glycosylation of rat renal renin J Biol Chem (15-4-1991) 266, 7044-7050. PubMed Europe PubMed
Pravenec,M., Simonet,L., Kren,V., Kunes,J., Levan,G., Szpirer,J., Szpirer,C. and Kurtz,T. The rat renin gene: assignment to chromosome 13 and linkage to the regulation of blood pressure Genomics (1991) 9, 466-472. PubMed Europe PubMed
Rahuel,J., Priestle,J.P. and Grutter,M.G. The crystal structures of recombinant glycosylated human renin alone and in complex with a transition state analog inhibitor J Struct Biol (1991) 107, 227-236. PubMed Europe PubMed S I

1990

Glassman,H.N., Kleinert,H.D., Boger,R.S., Moyse,D.M., Griffiths,A.N. and Luther,R.R. Clinical pharmacology of enalkiren, a novel, dipeptide renin inhibitor J Cardiovasc Pharmacol (1990) 16 Suppl 4, S76-S81. PubMed Europe PubMed I
[YEAR:27-3-1990]Green,D.W., Aykent,S., Gierse,J.K. and Zupec,M.E. Substrate specificity of recombinant human renal renin: effect of histidine in the P2 subsite on pH dependence Biochemistry (27-3-1990) 29, 3126-3133. PubMed Europe PubMed
Greenlee,W.J. Renin inhibitors Med Res Rev (1990) 10, 173-236. PubMed Europe PubMed V I
Harada,H., Iyobe,A., Tsubaki,A., Yamaguchi,T., Hirata,K., Kamijo,T., Iizuka,K. and Kiso,Y. A practical synthesis of an orally potent renin inhibitor, isopropyl (2R,3S)-4-cyclohexyl-2-hydroxy-3-{N-[(2R)-2-morpholinocarbonylmethyl-3-(1- naphthyl)propionyl]-L-histidyl}aminobutyrate Chem Soc J [Perkin 1] (1990) 1, 2497-2500. I
Iizuka,K., Kamijo,T., Harada,H., Akahane,K., Kubota,T., Umeyama,H., Ishida,T. and Kiso,Y. Orally potent human renin inhibitors derived from angiotensinogen transition state: design, synthesis, and mode of interaction J Med Chem (1990) 33, 2707-2714. PubMed Europe PubMed
Kempf,D.J., de Lara,E., Stein,H.H., Cohen,J., Egan,D.A. and Plattner,J.J. Renin inhibitors based on dipeptide analogues. Incorporation of the hydroxyethylene isostere at the P2/P3 sites J Med Chem (1990) 33, 371-374. PubMed Europe PubMed DOI I
Ohkubo,H., Kawakami,H., Kakehi,Y., Takumi,T., Arai,H., Yokota,Y., Iwai,M., Tanabe,Y., Masu,M. and Hata,J. Generation of transgenic mice with elevated blood pressure by introduction of the rat renin and angiotensinogen genes Proc Natl Acad Sci U S A (1990) 87, 5153-5157. PubMed Europe PubMed DOI PMC EPMC
Rosenberg,S.H., Dellaria,J.F., Kempf,D.J., Hutchins,C.W., Woods,K.W., Maki,R.G., de Lara,E., Spina,K.P., Stein,H.H. and Cohen,J. Potent, low molecular weight renin inhibitors containing a C-terminal heterocycle: hydrogen bonding at the active site J Med Chem (1990) 33, 1582-1590. PubMed Europe PubMed DOI I
Shiratori,Y., Nakagawa,S., Hori,H., Murakami,K. and Umeyama,H. Protein modeling of human prorenin using the molecular dynamics method J Mol Graph (1990) 8, 163-167. PubMed Europe PubMed S
Thaisrivongs,S., Mao,B., Pals,D.T., Turner,S.R. and Kroll,L.T. Renin inhibitory peptides. A beta-aspartyl residue as a replacement for the histidyl residue at the P-2 site J Med Chem (1990) 33, 1337-1343. PubMed Europe PubMed
Yamauchi,T., Nagahama,M., Watanabe,T., Ishizuka,Y., Hori,H. and Murakami,K. Site-directed mutagenesis of human prorenin. Substitution of three arginine residues in the propeptide with glutamine residues yields active prorenin J Biochem (1990) 107, 27-31. PubMed Europe PubMed

1989

[YEAR:5-5-1989]Burt,D.W., Nakamura,N., Kelley,P. and Dzau,V.J. Identification of negative and positive regulatory elements in the human renin gene J Biol Chem (5-5-1989) 264, 7357-7362. PubMed Europe PubMed
[YEAR:5-9-1989]Higashimori,K., Mizuno,K., Nakajo,S., Boehm,F.H., Marcotte,P.A., Egan,D.A., Holleman,W.H., Heusser,C., Poisner,A.M. and Inagami,T. Pure human inactive renin. Evidence that native inactive renin is prorenin J Biol Chem (5-9-1989) 264, 14662-14667. PubMed Europe PubMed
Inagami,T. Structure and function of renin J Hypertens Suppl (1989) 7, S3-S8. PubMed Europe PubMed
Sielecki,A.R., Hayakawa,K., Fujinaga,M., Murphy,M.E., Fraser,M., Muir,A.K., Carilli,C.T., Lewicki,J.A., Baxter,J.D. and James,M.N. Structure of recombinant human renin, a target for cardiovascular-active drugs, at 2.5 A resolution Science (1989) 243, 1346-1351. PubMed Europe PubMed
Wood,J.M., Criscione,L., de Gasparo,M., Buhlmayer,P., Rueger,H., Stanton,J.L., Jupp,R.A. and Kay,J. CGP 38 560: orally active, low-molecular-weight renin inhibitor with high potency and specificity J Cardiovasc Pharmacol (1989) 14, 221-226. PubMed Europe PubMed I

1988

Yamauchi,T., Nagahama,M., Hori,H. and Murakami,K. Functional characterization of Asp-317 mutant of human renin expressed in COS cells FEBS Lett (1988) 230, 205-208. PubMed Europe PubMed DOI

1987

Bolis,G., Fung,A.K., Greer,J., Kleinert,H.D., Marcotte,P.A., Perun,T.J., Plattner,J.J. and Stein,H.H. Renin inhibitors. Dipeptide analogues of angiotensinogen incorporating transition-state, nonpeptidic replacements at the scissile bond J Med Chem (1987) 30, 1729-1737. PubMed Europe PubMed I
Burnham,C.E., Hawelu-Johnson,C.L., Frank,B.M. and Lynch,K.R. Molecular cloning of rat renin cDNA and its gene Proc Natl Acad Sci U S A (1987) 84, 5605-5609. PubMed Europe PubMed PMC EPMC
[YEAR:25-2-1987]Derkx,F.H., Schalekamp,M.P. and Schalekamp,M.A. Two-step prorenin-renin conversion. Isolation of an intermediary form of activated prorenin J Biol Chem (25-2-1987) 262, 2472-2477. PubMed Europe PubMed
[YEAR:25-1-1987]Do,Y.S., Shinagawa,T., Tam,H., Inagami,T. and Hsueh,W.A. Characterization of pure human renal renin. Evidence for a subunit structure J Biol Chem (25-1-1987) 262, 1037-1043. PubMed Europe PubMed
Hui,K.Y., Carlson,W.D., Bernatowicz,M.S. and Haber,E. Analysis of structure-activity relationships in renin substrate analogue inhibitory peptides J Med Chem (1987) 30, 1287-1295. PubMed Europe PubMed I
Kempf,D.J., de Lara,E., Stein,H.H., Cohen,J. and Plattner,J.J. Renin inhibitors based on novel dipeptide analogues. Incorporation of the dehydrohydroxyethylene isostere at the scissile bond J Med Chem (1987) 30, 1978-1983. PubMed Europe PubMed I
Pinet,F., Mizrahi,J., Laboulandine,I., Menard,J. and Corvol,P. Regulation of prorenin secretion in cultured human transfected juxtaglomerular cells J Clin Invest (1987) 80, 724-731. PubMed Europe PubMed DOI PMC EPMC
Takada,Y., Maruta,H., Wagner,B., FA,X.G., James,H.L. and Erdos,E.G. Activation of human prorenin by neutrophil elastase J Clin Endocrinol Metab (1987) 65, 1225-1230. PubMed Europe PubMed DOI

1986

Poorman,R.A., Palermo,D.P., Post,L.E., Murakami,K., Kinner,J.H., Smith,C.W., Reardon,I. and Heinrikson,R.L. Isolation and characterization of native human renin derived from Chinese hamster ovary cells Proteins (1986) 1, 139-145. PubMed Europe PubMed DOI
Soubrier,F., Panthier,J.J., Houot,A.M., Rougeon,F. and Corvol,P. Segmental homology between the promoter region of the human renin gene and the mouse ren1 and ren2 promoter regions Gene (1986) 41, 85-92. PubMed Europe PubMed

1985

Boger,J., Payne,L.S., Perlow,D.S., Lohr,N.S., Poe,M., Blaine,E.H., Ulm,E.H., Schorn,T.W., LaMont,B.I. and Lin,T.Y. Renin inhibitors. Syntheses of subnanomolar, competitive, transition-state analogue inhibitors containing a novel analogue of statine J Med Chem (1985) 28, 1779-1790. PubMed Europe PubMed I
Boger,J. Chapter 26. Renin Inhibition Annu Rep Med Chem (1985) 20, 257-266. DOI I
[YEAR:5-8-1985]Cumin,F., Evin,G., Fehrentz,J.A., Seyer,R., Castro,B., Menard,J. and Corvol,P. Inhibition of human renin by synthetic peptides derived from its prosegment J Biol Chem (5-8-1985) 260, 9154-9157. PubMed Europe PubMed
Szelke,M., Tree,M., Leckie,B.J., Jones,D.M., Atrash,B., Beattie,S., Donovan,B., Hallett,A., Hughes,M. and Lever,A.F. A transition-state analogue inhibitor of human renin (H.261): test in vitro and a comparison with captopril in the anaesthetized baboon J Hypertens (1985) 3, 13-18. PubMed Europe PubMed DOI I
Webb,D.J., Manhem,P.J., Ball,S.G., Inglis,G., Leckie,B.J., Lever,A.F., Morton,J.J., Robertson,J.I., Murray,G.D. and Menard,J. A study of the renin inhibitor H142 in man J Hypertens (1985) 3, 653-658. PubMed Europe PubMed I

1984

Chirgwin,J.M., Schaefer,I.M., Rotwein,P.S., Piccini,N., Gross,K.W. and Naylor,S.L. Human renin gene is on chromosome 1 Somat Cell Mol Genet (1984) 10, 415-421. PubMed Europe PubMed
Haber,E. The first Sir George Pickering memorial lecture. Which inhibitors will give us true insight into what renin really does? J Hypertens (1984) 2, 223-230. PubMed Europe PubMed I
Hardman,J.A., Hort,Y.J., Catanzaro,D.F., Tellam,J.T., Baxter,J.D., Morris,B.J. and Shine,J. Primary structure of the human renin gene DNA (1984) 3, 457-468. PubMed Europe PubMed
Miyazaki,H., Fukamizu,A., Hirose,S., Hayashi,T., Hori,H., Ohkubo,H., Nakanishi,S. and Murakami,K. Structure of the human renin gene Proc Natl Acad Sci U S A (1984) 81, 5999-6003. PubMed Europe PubMed PMC EPMC
Pandey,K.N., Melner,M.H., Parmentier,M. and Inagami,T. Demonstration of renin activity in purified rat Leydig cells: evidence for the existence of an endogenous inactive (latent) form of enzyme Endocrinology (1984) 115, 1753-1759. PubMed Europe PubMed DOI
[YEAR:1-8-1984]Poe,M., Wu,J.K., Lin,T.Y., Hoogsteen,K., Bull,H.G. and Slater,E.E. Renin cleavage of a human kidney renin substrate analogous to human angiotensinogen, H-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Ser-OH, that is human renin specific and is resistant to cathepsin D Anal Biochem (1-8-1984) 140, 459-467. PubMed Europe PubMed P

1983

[YEAR:5-5-1983]Boger,J., Lohr,N.S., Ulm,E.H., Poe,M., Blaine,E.H., Fanelli,G.M., Lin,T.Y., Payne,L.S., Schorn,T.W., LaMont,B.I., Vassil,T.C., Stabilito,I.I., Veber,D.F., Rich,D.H. and Bopari,A.S. Novel renin inhibitors containing the amino acid statine Nature (5-5-1983) 303, 81-84. PubMed Europe PubMed I
[YEAR:1-5-1983]McIntyre,G.D., Leckie,B., Hallett,A. and Szelke,M. Purification of human renin by affinity chromatography using a new peptide inhibitor of renin, H.77 (D-His-Pro-Phe-His-LeuR-Leu-Val-Tyr) Biochem J (1-5-1983) 211, 519-522. PubMed Europe PubMed PMC EPMC I
Tree,M., Atrash,B., Donovan,B., Gamble,J., Hallett,A., Hughes,M., Jones,D.M., Leckie,B., Lever,A.F. and Morton,J.J. New inhibitors of human renin tested in vitro and in vivo in the anaesthetized baboon J Hypertens (1983) 1, 399-403. PubMed Europe PubMed I
Webb,D.J., Cumming,A.M., Leckie,B.J., Lever,A.F., Morton,J.J., Robertson,J.I., Szelke,M. and Donovan,B. Reduction of blood pressure in man with H-142, a potent new renin inhibitor Lancet (1983) 2, 1486-1487. PubMed Europe PubMed I

1982

Mullins,J.J., Burt,D.W., Windass,J.D., McTurk,P., George,H. and Brammar,W.J. Molecular cloning of two distinct renin genes from the DBA/2 mouse EMBO J (1982) 1, 1461-1466. PubMed Europe PubMed PMC EPMC
Ondetti,M.A. and Cushman,D.W. Enzymes of the renin-angiotensin system and their inhibitors Annu Rev Biochem (1982) 51, 283-308. PubMed Europe PubMed DOI V I
[YEAR:7-10-1982]Szelke,M., Leckie,B., Hallett,A., Jones,D.M., Sueiras,J., Atrash,B. and Lever,A.F. Potent new inhibitors of human renin Nature (7-10-1982) 299, 555-557. PubMed Europe PubMed I
[YEAR:15-1-1982]Takii,Y. and Inagami,T. Purification of a completely inactive renin from hog kidney and identification as renin zymogen Biochem Biophys Res Commun (15-1-1982) 104, 133-140. PubMed Europe PubMed

1981

[YEAR:1-8-1981]Eid,M., Evin,G., Castro,B., Menard,J. and Corvol,P. New renin inhibitors homologous with pepstatin Biochem J (1-8-1981) 197, 465-471. PubMed Europe PubMed PMC EPMC I
[YEAR:1-1-1981]Murakami,K., Ohsawa,T., Hirose,S., Takada,K. and Sakakibara,S. New fluorogenic substrates for renin Anal Biochem (1-1-1981) 110, 232-239. PubMed Europe PubMed A
Slater,E.E. Renin Methods Enzymol (1981) 80, 427-442. PubMed Europe PubMed DOI V
Slater,E.E. and Strout,H.V., Jr. Pure human renin. Identification and characterization of two major molecular weight forms J Biol Chem (1981) 256, 8164-8171. PubMed Europe PubMed

1980

[YEAR:17-11-1980]Cody,R.J., Burton,J., Evin,G., Poulsen,K., Herd,J.A. and Haber,E. A substrate analog inhibitor of renin that is effective in vivo Biochem Biophys Res Commun (17-11-1980) 97, 230-235. PubMed Europe PubMed I
Conio,G., Ghiani,P., Patrone,E., Trefiletti,V., Uva,B. and Vallarino,M. Isolation and characterization of multiple forms of renin from bull kidney Biochim Biophys Acta (1980) 623, 317-328. PubMed Europe PubMed
Johnson,R.L. and Poisner,A.M. Inactivation of amniotic prorenin by ethyl diazoacetylglycinate Biochem Biophys Res Commun (1980) 95, 1404-1409. PubMed Europe PubMed I

1979

[YEAR:10-6-1979]Galen,F.X., Devaux,C., Guyenne,T., Menard,J. and Corvol,P. Multiple forms of human renin. Purification and characterization J Biol Chem (10-6-1979) 254, 4848-4855. PubMed Europe PubMed
Marks,L.S. and Maxwell,M.H. Tigerstedt and the discovery of renin. An historical note Hypertension (1979) 1, 384-388. PubMed Europe PubMed
Poulsen,K., Vuust,J., Lykkegaard,S., Nielsen,A.H. and Lund,T. Renin is synthesized as a 50,000 dalton single-chain polypeptide in cell-free translation systems FEBS Lett (1979) 98, 135-138. PubMed Europe PubMed

1978

Evin,G., Gardes,J., Kreft,C., Castro,B., Corvol,P. and Menard,J. Soluble pepstatins: a new approach to blockade in vivo of the renin-angiotensin system Clin Sci Mol Med (1978) 55, 167s-169s. I
[YEAR:12-10-1978]Matoba,T., Murakami,K. and Inagami,T. Rat renin: purification and characterization Biochim Biophys Acta (12-10-1978) 526, 560-571. PubMed Europe PubMed
Miyazaki,M., Okunishi,H., Komori,T. and Yamamoto,K. Renin inhibitory effect of N-acetyl-pepstatin Jpn J Pharmacol (1978) 28, 171-174. PubMed Europe PubMed I

1977

Corvol,P., Devaux,C., Ito,T., Sicard,P., Ducloux,J. and Menard,J. Large scale purification of hog renin. Physicochemical characterization Circ Res (1977) 41, 616-622. PubMed Europe PubMed
Inagami,T. and Murakami,K. Pure renin. Isolation from hog kidney and characterization J Biol Chem (1977) 252, 2978-2983. PubMed Europe PubMed
Inagami,T., Murakami,K., Misono,K., Workman,R.J., Cohen,S. and Suketa,Y. Renin and precursors: purification, characterization, and studies on active site Adv Exp Med Biol (1977) 95, 225-247. PubMed Europe PubMed

1976

Lentz,K.E., Skeggs,L.T., Dorer,F.E., Kahn,J.R. and Levine,M. A new radiolabeled protein renin substrate Anal Biochem (1976) 74, 1-11. PubMed Europe PubMed DOI A
Swales,J.D., Amery,A., Lijnen,P., Fagard,R. and Reybrouck,T. Inactive renin in human plasma Lancet (1976) 308, 849-850. DOI

1975

[YEAR:26-8-1975]Burton,J., Poulsen,K. and Haber,E. Competitive inhibitors of renin. Inhibitors effective at physiological pH Biochemistry (26-8-1975) 14, 3892-3898. PubMed Europe PubMed I
[YEAR:1-1-1975]McKown,M.M. and Gregerman,R.I. Human renin inhibition by a diazoacyl reagent: relationship of the enzyme to other proteinases Life Sci (1-1-1975) 16, 71-79. PubMed Europe PubMed

1974

[YEAR:25-12-1974]McKown,M.M., Workman,R.J. and Gregerman,R.I. Pepstatin inhibition of human renin. Kinetic studies and estimation of enzyme purity J Biol Chem (25-12-1974) 249, 7770-7774. PubMed Europe PubMed I

1973

[YEAR:15-10-1973]Parikh,I. and Cuatrecasas,P. Substrate analog competitive inhibitors of human renin Biochem Biophys Res Commun (15-10-1973) 54, 1356-1361. PubMed Europe PubMed I
[YEAR:25-9-1973]Poulsen,K., Burton,J. and Haber,E. Competitive inhibitors of renin Biochemistry (25-9-1973) 12, 3877-3882. PubMed Europe PubMed I

1972

Gross,F., Lazar,J. and Orth,H. Inhibition of the renin-angiotensinogen reaction by pepstatin Science (1972) 175, 656-656. PubMed Europe PubMed I

1970

Smeby,R.R. and Bumpus,F.M. [51] Renin Methods Enzymol (1970) 19, 699-706. DOI

1969

Reinharz,A. and Roth,M. Studies on renin with synthetic substrates Eur J Biochem (1969) 7, 334-339. PubMed Europe PubMed

1968

[YEAR:1-7-1968]Skeggs,L.T., Lentz,K.E., Kahn,J.R. and Hochstrasser,H. Kinetics of the reaction of renin with nine synthetic peptide substrates J Exp Med (1-7-1968) 128, 13-34. PubMed Europe PubMed PMC EPMC P I

1965

Arakawa,K., Nakatani,M. and Nakamura,M. Species specificity in reaction between renin and angiotensinogen Nature (1965) 207, 636-636. PubMed Europe PubMed DOI

1964

Mazur,R.H. and Schlatter,J.M. Synthesis of a renin substrate J Org Chem (1964) 29, 3212-3216.

1962

Kemp,E. and Rubin,I. Renin purification by DEAE cellulose chromatography Scand J Clin Lab Invest (1962) 14, 207-211. PubMed Europe PubMed

1942

Schales,O. Preparation and properties of renin J Am Chem Soc (1942) 64, 561-564.

1941

Wakerlin,G.E., Johnson,C.A., Gomberg,B. and Goldberg,M.L. Reduction in the blood pressures of renal hypertensive dogs with hog renin Science (1941) 93, 332-332. PubMed Europe PubMed DOI

1940

Braun-Menendez,E., Fasciolo,J.C., Leloir,L.F. and Munoz,J.M. The substance causing renal hypertension J Physiol (1940) 98, 283-298. PubMed Europe PubMed PMC EPMC
Page,I.H. and Helmer,O.M. A CRYSTALLINE PRESSOR SUBSTANCE (ANGIOTONIN) RESULTING FROM THE REACTION BETWEEN RENIN AND RENIN-ACTIVATOR J Exp Med (1940) 71, 29-42. PubMed Europe PubMed PMC EPMC

1898

Tigerstedt,R. and Bergmann,P. Niere und kreislauf Skand Arch Physiol (1898) 8, 223-271.

1890

Lea,A.S. and Dickinson,W.L. Notes on the mode of action of rennin and fibrin-ferment J Physiol (1890) 11, 307-311. PubMed Europe PubMed

1840

Deschamps,J.B. [De la pressure] J Pharm Acc (1840) 26, 412-420.