Literature for peptidase A01.007: renin

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

(Topics flags: A Assay, S Structure, T Target, P Specificity, K Knockout, E Expression, V Review, M Mutation, I Inhibitor, L Localization. To select only the references relevant to a single topic, click the link above. See explanation.)

2025

Adhikari,A., Sharma,C., Lhamu Sherpa,M., Karaunakran,G., Dhakal,M. and Sharma,A.
Impact of Renin-Angiotensin-Aldosterone System (RAAS) Gene Polymorphism in Essential Hypertension and Antihypertensive Drug Therapy: A Review
Int J Hypertens2025, 5530265-5530265. PubMed Europe PubMed DOI V
Nunez,F.F., Siqueiros-Marquez,L., Adan-Castro,E., Zamora,M., Robles,J.P., Ruiz-Herrera,X., Bertsch,T., Triebel,J., Martinez de la Escalera,G. and Clapp,C.
Vasoinhibin is generated by the Renin-Angiotensin System
Endocrinology PubMed Europe PubMed DOI
Trerattanavong,K. and Chen,J.
Biochemistry, Renin
PubMed Europe PubMed
Valiente,P.A., Guerra,Y., Wolf,M.G., Pascual,I., Rudino-Pinera,E., Florent,I., Pons,T. and Groenhof,G.
Discovery of a Noncompetitive Open-Flap Selective Inhibitor of Plasmepsin II with Antiplasmodial Activity
J Chem Inf Model PubMed Europe PubMed DOI I

2024

Chakradhar,A., Baron,R.M., Vera,M.P., Devarajan,P., Chawla,L. and Hou,P.C.
Plasma renin as a novel prognostic biomarker of sepsis-associated acute respiratory distress syndrome
Sci Rep14, 6667-6667. PubMed Europe PubMed DOI V
Kotani,Y., Belletti,A., Maiucci,G., Lodovici,M., Fresilli,S., Landoni,G., Bellomo,R. and Zarbock,A.
Renin as a Prognostic Marker in Intensive Care and Perioperative Settings: A Scoping Review
Anesth Analg138, 929-936. PubMed Europe PubMed DOI V
Kotani,Y., Chappell,M., Landoni,G., Zarbock,A., Bellomo,R. and Khanna,A.K.
Renin in critically ill patients
Ann Intensive Care14, 79-79. PubMed Europe PubMed DOI V
Schalekamp,M.A.D.H., Deinum,J. and Danser,A.H.J.
Short-Lived Active Prorenin: Precursor of So-Called Native Prorenin
Hypertension81, 1190-1193. PubMed Europe PubMed DOI
Shen,Y., Lotenberg,K., Zaworski,J., Broeker,K.A., Vasseur,F., Louedec,L., Placier,S., Frere,P., Verpont,M.C., Galichon,P., Buob,D., Hadchouel,J., Terzi,F., Chatziantoniou,C. and Calmont,A.
Neuropilin-1 regulates renin synthesis in juxtaglomerular cells
J Physiol602, 1815-1833. PubMed Europe PubMed DOI
Triebel,H. and Castrop,H.
The renin angiotensin aldosterone system
Pflugers Arch476, 705-713. PubMed Europe PubMed DOI V
Zhang,Y., Martin,B., Spies,M.A., Roberts,S.M., Nott,J., Goodfellow,R.X., Nelson,A.F.M., Blain,S.J., Redondo,E., Nester,C.M. and Smith,R.J.H.
Renin and renin blockade have no role in complement activity
Kidney Int105, 328-337. PubMed Europe PubMed DOI

2023

Akther,J., Nabi,A.H.M.N., Ohno,S., Yokogawa,T., Nakagawa,T., Suzuki,F. and Ebihara,A.
Corrigendum to "establishing a novel assay system for measuring renin concentration using cost effective recombinant ovine angiotensinogen"
Heliyon9, e13123-e13123. PubMed Europe PubMed DOI
Loganathan,L., Sankar,J., Rajendran,K. and Muthusamy,K.
Theoretical investigation on known renin inhibitors and generation of ligand-based pharmacophore models for hypertension treatment
J Biomol Struct Dyn1-10. PubMed Europe PubMed DOI
Moguel-Concha,D.D.R., Borges-Martinez,J.E., Cid-Gallegos,M.S., Juarez-Chairez,M.F., Gomez-Gomez,A.L., Tellez-Medina,D.I. and Jimenez-Martinez,C.
Antioxidant and Renin Inhibitory Activities of Peptides from Food Proteins on Hypertension: A Review
Plant Foods Hum Nutr78, 493-505. PubMed Europe PubMed DOI V
Ostrowski,J. and Kurkus,J.
Robert Tigerstedt and the Discovery of Renin
Exp Clin Transplant21, 62-66. PubMed Europe PubMed DOI
Wang,C., Wang,Z., Xu,J., Ma,H., Jin,K., Xu,T., Pan,X., Feng,X. and Zhang,W.
C3aR Antagonist Alleviates C3a Induced Tubular Profibrotic Phenotype Transition via Restoring PPARalpha/CPT-1alpha Mediated Mitochondrial Fatty Acid Oxidation in Renin-Dependent Hypertension
Front Biosci (Landmark Ed)28, 238-238. PubMed Europe PubMed DOI

2022

Iijima,D., Sugama,H., Awai,N., Takahashi,Y., Togashi,Y., Takebe,T., Xie,J., Shen,J., Ke,Y., Akatsuka,H., Kawaguchi,T., Takedomi,K., Kashima,A., Nishio,M., Inui,Y., Yoneda,H., Xia,G. and Iijima,T.
Discovery of Novel 2-Carbamoyl Morpholine Derivatives as Highly Potent and Orally Active Direct Renin Inhibitors
ACS Med Chem Lett13, 1351-1357. PubMed Europe PubMed DOI
Iijima,D., Sugama,H., Takahashi,Y., Hirai,M., Togashi,Y., Xie,J., Shen,J., Ke,Y., Akatsuka,H., Kawaguchi,T., Takedomi,K., Kashima,A., Nishio,M., Inui,Y., Yoneda,H., Xia,G. and Iijima,T.
Discovery of SPH3127: A Novel, Highly Potent, and Orally Active Direct Renin Inhibitor
J Med Chem65, 10882-10897. PubMed Europe PubMed DOI I
Piesanen,J., Valjakka,J., Niemela,S., Borgenstrom,M., Nikkari,S., Hytonen,V., Maatta,J. and Kunnas,T.
Hepcidin is potential regulator for renin activity
PLoS ONE17, e0267343-e0267343. PubMed Europe PubMed DOI
Senbonmatsu,T.
Prorenin: What are its functions?
Hypertens Res45, 2021-2023. PubMed Europe PubMed DOI
Yokota,H., Hayashi,H., Hanaguri,J., Yamagami,S., Kushiyama,A., Nakagami,H. and Nagaoka,T.
Effect of prorenin peptide vaccine on the early phase of diabetic retinopathy in a murine model of type 2 diabetes
PLoS ONE17, e0262568-e0262568. PubMed Europe PubMed DOI

2021

Akther,J., Das,A., Rahman,M.A., Saha,S.K., Hosen,M.I., Ebihara,A., Nakagawa,T., Suzuki,F. and Nabi,A.H.M.N.
Non-coding Single Nucleotide Variants of Renin and the (Pro)renin Receptor are Associated with Polygenic Diseases in a Bangladeshi Population
Biochem Genet PubMed Europe PubMed DOI M
Grahame,D.A.S., Dupuis,J.H., Bryksa,B.C., Tanaka,T. and Yada,R.Y.
Improving the alkaline stability of pepsin through rational protein design using renin, an alkaline-stable aspartic protease, as a structural and functional reference
Enzyme Microb Technol150, 109871-109871. PubMed Europe PubMed DOI
Ma,S., Henderson,J.A. and Shen,J.
Exploring the pH-Dependent Structure-Dynamics-Function Relationship of Human Renin
J Chem Inf Model61, 400-407. PubMed Europe PubMed DOI
Murray,J.B., Mikhael,C., Han,G., de Faria,L.P., Rody,W.J., Jr. and Holliday,L.S.
Activation of (pro)renin by (pro)renin receptor in extracellular vesicles from osteoclasts
Sci Rep11, 9214-9214. PubMed Europe PubMed DOI
Prieto,M.C., Gonzalez,A.A., Visniauskas,B. and Navar,L.G.
The evolving complexity of the collecting duct renin-angiotensin system in hypertension
Nat Rev Nephrol PubMed Europe PubMed DOI
Refaey,R.H., El-Ashrey,M.K. and Nissan,Y.M.
Repurposing of renin inhibitors as SARS-COV-2 main protease inhibitors: A computational study
Virology554, 48-54. PubMed Europe PubMed DOI I

2020

Abdel Ghafar,M.T.
An overview of the classical and tissue-derived renin-angiotensin-aldosterone system and its genetic polymorphisms in essential hypertension
Steroids163, 108701-108701. PubMed Europe PubMed DOI
Alhenc-Gelas,F.
A new channel for the control of renin secretion in juxtaglomerular cells
Kidney Int98, 543-545. PubMed Europe PubMed DOI
Alsufyani,H.A. and Docherty,J.R.
The renin angiotensin aldosterone system and COVID-19
Saudi Pharm J28, 977-984. PubMed Europe PubMed DOI V
Bartova,E., Legartova,S., Krejci,J. and Arcidiacono,O.A.
Cell differentiation and aging accompanied by depletion of the ACE2 protein
Aging (Albany NY)12, 22495-22508. PubMed Europe PubMed DOI
Dilliott,A.A., Wang,J., Brown,E., Singh,G., Shkrum,M.J., Clin,M., Rupar,C.A., Hegele,R.A. and Siu,V.M.
A novel homozygous variant in REN in a family presenting with classic features of disorders involving the renin-angiotensin pathway, without renal tubular dysgenesis
Am J Med Genet A182, 2284-2290. PubMed Europe PubMed DOI
Docherty,K.F., Campbell,R.T., Brooksbank,K.J.M., Godeseth,R.L., Forsyth,P., McConnachie,A., Roditi,G., Stanley,B., Welsh,P., Jhund,P.S., Petrie,M.C. and McMurray,J.J.V.
Rationale and methods of a randomized trial evaluating the effect of neprilysin inhibition on left ventricular remodelling
ESC Heart Fail PubMed Europe PubMed DOI I
Feng,Y., Peng,K., Luo,R., Wang,F. and Yang,T.
Site-1 Protease-Derived Soluble (Pro)Renin Receptor Contributes to Angiotensin II-Induced Hypertension in Mice
HypertensionHYPERTENSIONAHA12015100-HYPERTENSIONAHA12015100. PubMed Europe PubMed DOI
Grahame,D.S.A., Dupuis,J.H., Bryksa,B.C., Tanaka,T. and Yada,R.Y.
Comparative bioinformatic and structural analyses of pepsin and renin
Enzyme Microb Technol141, 109632-109632. PubMed Europe PubMed DOI
Hartford,M., Herlitz,H., Perers,E., Karlsson,T., Herlitz,J., Persson,A. and Caidahl,K.
Plasma renin activity has a complex prognostic role in patients with acute coronary syndromes
Int J Cardiol PubMed Europe PubMed DOI
Kobayashi,Y., Haze,T., Yano,Y., Tamura,K., Kurihara,I., Ichijo,T., Yoneda,T., Katabami,T., Tsuiki,M., Wada,N., Ogawa,Y., Kawashima,J., Sone,M., Inagaki,N., Yamada,T., Okamoto,R., Fujita,M., Kamemura,K., Yamamoto,K., Izawa,S., Tanabe,A. and Naruse,M.
Associations Between Changes in Plasma Renin Activity and Aldosterone Concentrations and Changes in Kidney Function After Treatment for Primary Aldosteronism
Kidney Int Rep5, 1291-1297. PubMed Europe PubMed DOI
Kurbel,S.
The renin-angiotensin system in COVID-19: Why ACE2 targeting by coronaviruses produces higher mortality in elderly hypertensive patients?
Bioessayse2000112-e2000112. PubMed Europe PubMed DOI
Liu,Y., Lin,Y., Zhang,M.M., Li,X.H., Liu,Y.Y., Zhao,J. and Shi,L.
The relationship of plasma renin, angiotensin, and aldosterone levels to blood pressure variability and target organ damage in children with essential hypertension
BMC Cardiovasc Disord20, 296-296. PubMed Europe PubMed DOI I
Lou,L.L., Xie,L., Hu,Y., Chen,L.N., Liang,P., Shi,F., Liu,C.J. and Liu,H.M.
[Association of age distribution with the expression of angiotensin-converting enzyme 2 in lung tissues in severe acute respiratory syndrome coronavirus 2 infection: reflections from the study of RAS pathway expression in mice]
Zhongguo Dang Dai Er Ke Za Zhi22, 1119-1124. PubMed Europe PubMed
Ma,W.J., Lou,Y., Bian,J., Cai,J., Zhang,H.M. and Zhou,X.L.
[Application of aldosterone/direct renin ratio before drug washout in the screening of primary aldosteronism]
Zhonghua Yi Xue Za Zhi100, 3250-3254. PubMed Europe PubMed DOI
Moin,A.S.M., Sathyapalan,T., Atkin,S.L. and Butler,A.E.
Renin-Angiotensin System overactivation in polycystic ovary syndrome, a risk for SARS-CoV-2 infection?
Metabol Open7, 100052-100052. PubMed Europe PubMed DOI
Salman,A.A., Salman,M.A., Shawkat,M., Hassan,S.A., Saad,E.H., Hussein,A.M., Refaie,O.R.M., Tourky,M.S., Shaaban,H.E., Abd Allah,N., El Domiaty,H.F. and Elkassar,H.
Effect of Laparoscopic Sleeve Gastrectomy on Vasoactive Mediators in Obese Hypertensive Patients: A Prospective Study
Clin Endocrinol (Oxf) PubMed Europe PubMed DOI
Siljee,S., Pilkington,T., Brasch,H.D., Bockett,N., Patel,J., Paterson,E., Davis,P.F. and Tan,S.T.
Cancer Stem Cells in Head and Neck Metastatic Malignant Melanoma Express Components of the Renin-Angiotensin System
Life (Basel)10, PubMed Europe PubMed DOI
Urushihara,M., Kondo,S., Kinoshita,Y., Ozaki,N., Jamba,A., Nagai,T., Fujioka,K., Hattori,T. and Kagami,S.
(Pro)renin receptor promotes crescent formation via the ERK1/2 and Wnt/beta-catenin pathways in glomerulonephritis
Am J Physiol Renal Physiol319, F571-F571. PubMed Europe PubMed DOI
Wanka,H., Lutze,P., Staar,D., Bracke,K., Golchert,J. and Peters,J.
Angiotensin dependent and angiotensin independent protective effects of renin-b in H9c2 cells after anoxia
Sci Rep10, 19689-19689. PubMed Europe PubMed DOI

2019

Yan,Y., Zhou,A., Carrell,R.W. and Read,R.J.
Structural basis for the specificity of renin-mediated angiotensinogen cleavage
J Biol Chem294, 2353-2364. PubMed Europe PubMed DOI S

2018

Nakano,D. and Nishiyama,A.
A novel role of renin inhibitor in the complement cascade
Kidney Int94, 650-652. PubMed Europe PubMed DOI I
Strecker,C. and Meyer,B.
Plasticity of the binding site of renin: optimized selection of protein structures for ensemble docking
J Chem Inf Model58, 1121-1131. PubMed Europe PubMed DOI I
Tavassoli,Z., Taghdir,M. and Ranjbar,B.
Renin inhibition by soyasaponin I: a potent native anti-hypertensive compound
J Biomol Struct Dyn36, 166-176. PubMed Europe PubMed DOI
Tokuhara,H., Imaeda,Y., Fukase,Y., Iwanaga,K., Taya,N., Watanabe,K., Kanagawa,R., Matsuda,K., Kajimoto,Y., Kusumoto,K., Kondo,M., Snell,G., Behnke,C.A. and Kuroita,T.
Discovery of benzimidazole derivatives as orally active renin inhibitors: optimization of 3,5-disubstituted piperidine to improve pharmacokinetic profile
Bioorg Med Chem26, 3261-3286. PubMed Europe PubMed DOI I

2017

Cloudsdale,I.S., Dickson JK Jr, Barta,T.E., Grella,B.S., Smith,E.D., Kulp JL 3rd, Guarnieri,F. and Kulp JL Jr
Design, synthesis and biological evaluation of renin inhibitors guided by simulated annealing of chemical potential simulations
Bioorg Med Chem25, 3947-3963. PubMed Europe PubMed DOI I
Fu,Y., Alashi,A.M., Young,J.F., Therkildsen,M. and Aluko,R.E.
Enzyme inhibition kinetics and molecular interactions of patatin peptides with angiotensin I-converting enzyme and renin
Int J Biol Macromol101, 207-213. PubMed Europe PubMed DOI I
Lawhorn,B.G., Tran,T., Hong,V.S., Morgan,L.A., Le,B.T., Harpel,M.R., Jolivette,L., Diaz,E., Schwartz,B., Gross,J.W., Tomaszek,T., Semus,S., Concha,N., Smallwood,A., Holt,D.A. and Kallander,L.S.
Discovery of renin inhibitors containing a simple aspartate binding moiety that imparts reduced P450 inhibition
Bioorg Med Chem Lett27, 4838-4843. PubMed Europe PubMed DOI I
Marszalek,D., Goldnik,A., Winiecka,I., Jaworsk,P. and Mazurek Aleksander,P.
New renin inhibitors - stability and activity determination. Part IV
Acta Pol Pharm74, 393-399. PubMed Europe PubMed I
Shinohara,K., Nakagawa,P., Gomez,J., Morgan,D.A., Littlejohn,N.K., Folchert,M.D., Weidemann,B.J., Liu,X., Walsh,S.A., Ponto,L.L., Rahmouni,K., Grobe,J.L. and Sigmund,C.D.
Selective deletion of renin-b in the brain alters drinking and metabolism
Hypertension70, 990-997. PubMed Europe PubMed DOI K
Wilkinson,M.C., Nightingale,D.J.H., Harrison,R.A. and Wagstaff,S.C.
Isolation and characterization of renin-like aspartic-proteases from Echis ocellatus venom
Toxicon137, 92-94. PubMed Europe PubMed DOI I

2016

Imaeda,Y., Tokuhara,H., Fukase,Y., Kanagawa,R., Kajimoto,Y., Kusumoto,K., Kondo,M., Snell,G., Behnke,C.A. and Kuroita,T.
Discovery of TAK-272: a novel, potent, and orally active renin inhibitor
ACS Med Chem Lett7, 933-938. PubMed Europe PubMed DOI I
Imaeda,Y., Tawada,M., Suzuki,S., Tomimoto,M., Kondo,M., Tarui,N., Sanada,T., Kanagawa,R., Snell,G., Behnke,C.A., Kubo,K. and Kuroita,T.
Structure-based design of a new series of N-(piperidin-3-yl)pyrimidine-5-carboxamides as renin inhibitors
Bioorg Med Chem24, 5771-5780. PubMed Europe PubMed DOI I
Ramanathan,G., Elumalai,R., Periyasamy,S. and Lakkakula,B.V.
Renin gene rs1464816 polymorphism contributes to chronic kidney disease progression in ADPKD
J Biomed Sci23, 1-1. PubMed Europe PubMed DOI M
Shinohara,K., Liu,X., Morgan,D.A., Davis,D.R., Sequeira-Lopez,M.L., Cassell,M.D., Grobe,J.L., Rahmouni,K. and Sigmund,C.D.
Selective deletion of the brain-specific isoform of renin causes neurogenic hypertension
Hypertension68, 1385-1392. PubMed Europe PubMed DOI K
Tawada,M., Suzuki,S., Imaeda,Y., Oki,H., Snell,G., Behnke,C.A., Kondo,M., Tarui,N., Tanaka,T., Kuroita,T. and Tomimoto,M.
Novel approach of fragment-based lead discovery applied to renin inhibitors
Bioorg Med Chem24, 6066-6074. PubMed Europe PubMed DOI I
Winiecka,I., Jaworski,P., Mazurek,A.P., Marszalek,D., Goldnik,A. and Sokulski,D.
Novel renin inhibitors containing derivatives of N-alkylleucyl-beta-hydroxy-gamma-amino acids
J Pept Sci22, 106-115. PubMed Europe PubMed DOI I

2015

da Mota,E.G., Duarte,M.H., Da Cunha,E.F.F. and Freitas,M.P.
Theoretical design of new indole-3-carboxamide derivatives as renin inhibitors
Med Chem Res24, 3097-3106. DOI I
Lorthiois,E., Cumin,F., Ehrhardt,C., Kosaka,T., Sellner,H., Ostermann,N., Francotte,E., Wagner,T. and Maibaum,J.
trans-(3S,4S)-Disubstituted pyrrolidines as inhibitors of the human aspartyl protease renin. Part I: Prime site exploration using an amino linker
Bioorg Med Chem Lett25, 1782-1786. PubMed Europe PubMed DOI I
McKittrick,B.A., Caldwell,J.P., Bara,T., Boykow,G., Chintala,M., Clader,J., Czarniecki,M., Courneya,B., Duffy,R., Fleming,L., Giessert,R., Greenlee,W.J., Heap,C., Hong,L., Huang,Y., Iserloh,U., Josien,H., Khan,T., Korfmacher,W., Liang,X., Mazzola,R., Mitra,S., Moore,K., Orth,P., Rajagopalan,M., Roy,S., Sakwa,S., Strickland,C., Vaccaro,H., Voigt,J., Wang,H., Wong,J., Zhang,R. and Zych,A.
Iminopyrimidinones: a novel pharmacophore for the development of orally active renin inhibitors
Bioorg Med Chem Lett25, 1592-1596. PubMed Europe PubMed DOI I
Park,J., Song,K., Jang,Y. and Kim Yoon,S.
A polymorphism of the renin gene rs6682082 is associated with essential hypertension risk and blood pressure levels in Korean women
Yonsei Med J56, 227-234. PubMed Europe PubMed DOI M
Raff,H., Gehrand,A., Bruder,E.D., Hoffman,M.J., Engeland,W.C. and Moreno,C.
Renin knockout rat: control of adrenal aldosterone and corticosterone synthesis in vitro and adrenal gene expression
Am J Physiol Regul Integr Comp PhysiolR73-R77. PubMed Europe PubMed DOI K
Sellner,H., Cottens,S., Cumin,F., Ehrhardt,C., Kosaka,T., Lorthiois,E., Ostermann,N., Webb,R.L., Rigel,D.F., Wagner,T. and Maibaum,J.
trans-3,4-Disubstituted pyrrolidines as inhibitors of the human aspartyl protease renin. Part II: Prime site exploration using an oxygen linker
Bioorg Med Chem Lett25, 1787-1791. PubMed Europe PubMed DOI I
Sequeira-Lopez,M.L., Nagalakshmi,V.K., Li,M., Sigmund,C.D. and Gomez,R.A.
Vascular versus tubular renin: role in kidney development
Am J Physiol Regul Integr Comp Physiol309, R650-R657. PubMed Europe PubMed DOI K
Sharma,M.C.
Structural insights into mode of actions of novel substituted 4- and 6-azaindole-3-carboxamides analogs as renin inhibitors: molecular modeling studies
Med Chem Res24, 1038-1059. DOI I
Sun,X., Wen,X., Chen,Y.Y., Shi,C., Gao,C., Wu,Y., Wang,L.J., Yang,X.H. and Sun,H.
Discovery of highly potent renin inhibitors potentially interacting with the S3' subsite of renin
Eur J Med Chem103, 269-288. PubMed Europe PubMed DOI I
Tzoupis,H., Leonis,G., Avramopoulos,A., Reis,H., Czyznikowska,Z., Zerva,S., Vergadou,N., Peristeras,L.D., Papavasileiou,K.D., Alexis,M.N., Mavromoustakos,T. and Papadopoulos,M.G.
Elucidation of the binding mechanism of renin using a wide array of computational techniques and biological assays
J Mol Graph Model62, 138-149. PubMed Europe PubMed DOI
Zhou,Z., Cheng,C. and Li,Y.
Structure-based design and optimization of antihypertensive peptides to obtain high inhibitory potency against both renin and angiotensin I-converting enzyme
SAR QSAR Environ Res26, 1001-1016. PubMed Europe PubMed DOI I

2014

Bras,N.F., Fernandes,P.A. and Ramos,M.J.
Molecular dynamics studies on both bound and unbound renin protease
J Biomol Struct Dyn32, 351-363. PubMed Europe PubMed DOI
Calixto,A.R., Bras,N.F., Fernandes,P.A. and Ramos,M.J.
Reaction mechanism of human renin studied by quantum mechanics/molecular mechanics (QM/MM) calculations
ACS Catal4, 3869-3876. DOI
Ehara,T., Irie,O., Kosaka,T., Kanazawa,T., Breitenstein,W., Grosche,P., Ostermann,N., Suzuki,M., Kawakami,S., Konishi,K., Hitomi,Y., Toyao,A., Gunji,H., Cumin,F., Schiering,N., Wagner,T., Rigel,D.F., Webb,R.L., Maibaum,J. and Yokokawa,F.
Structure-based design of substituted piperidines as a new class of highly efficacious oral direct renin inhibitors
ACS Med Chem Lett5, 787-792. PubMed Europe PubMed DOI I
Konoshita,T., Nakaya,T., Sakai,A., Yamada,M., Ichikawa,M., Sato,S., Imagawa,M., Fujii,M., Yamamoto,K., Makino,Y., Arakawa,K., Suzuki,J. and Ishizuka,T.
Determinants of plasma renin activity: role of a human renin gene variant as a genetic factor
Medicine (Baltimore)93, e354-e354. PubMed Europe PubMed DOI M
Lu,X., Krop,M., Batenburg,W.W., Musterd-Bhaggoe,U.M., Garrelds,I.M. and Danser,A.H.
Renin inhibitor VTP-27999 differs from aliskiren: focus on their intracellular accumulation and the (pro)renin receptor
J Hypertens32, 1255-1263. PubMed Europe PubMed DOI I
Marszalek,D., Goldnik,A., Mazurek,A.P., Winiecka,I. and Jaworskpi,P.
New renin inhibitors - stability and activity determination. Part I
Acta Pol Pharm71, 545-553. PubMed Europe PubMed I
Marszalek,D., Goldnik,A., Mazurek,A.P., Winiecka,I., Jaworski,P., Szerszan,S., Kozikowska,E. and Pawlik,T.
New renin inhibitors - stability and activity determination. Part II
Acta Pol Pharm71, 555-561. PubMed Europe PubMed I
Mori,Y., Iwamoto,M., Mori,K., Yoshida,M., Honda,T., Nagayama,T. and Nishi,T.
An efficient synthesis of (3S,5S)-5-[3,3-dimethyl-1-(o-tolyl)-6-OXO-2H- pyridin-4-YL]- piperidine-3-carboxamide as potent renin inhibitor
Heterocycles89, 1413-1426. DOI I
Shieh,W.-C., Du,Z., Kim,H., Liu,Y. and Prashad,M.
Development of a total telescoped synthesis of a renin inhibitor containing 3,4,5-substituted piperidine with sterically hindered amide bonds
Org Process Res Dev18, 1339-1344. DOI I
Weber,M.A.
John Laragh and the renin thesis: creating a paradigm
Am J Hypertens27, 1008-1009. PubMed Europe PubMed DOI V
Winiecka,I., Marszalek,D., Goldnik,A., Jaworski,P. and Mazurek,A.P.
Novel renin inhibitors containing a non-peptide aminoalkanoyl moiety at P1-P1' position
Pharmazie69, 263-270. PubMed Europe PubMed DOI I
Winiecka,I., Marszalek,D., Goldnik,A., Jaworski,P. and Mazurek,A.P.
New renin inhibitors containing phenylalanylhistidyl-gamma-amino acid derivatives in P3 - P1' position
Acta Pol Pharm71, 59-69. PubMed Europe PubMed I
Xa,L.K., Lacombe,M.J., Mercure,C., Lazure,C. and Reudelhuber,T.L.
General lysosomal hydrolysis can process prorenin accurately
Am J Physiol Regul Integr Comp Physiol307, R505-R513. PubMed Europe PubMed DOI
Xiang,Y., Song,J. and Zhang,Z.
Topomer CoMFA and virtual screening studies of azaindole class renin inhibitors
Comb Chem High Throughput Screen17, 458-472. PubMed Europe PubMed DOI I

2013

Harmsen,R.A.G., Sivertsen,A., Michetti,D., Brandsdal,B.O., Sydnes,L.K. and Haug,B.E.
Synthesis and docking of novel piperidine renin inhibitors
Monatsh Chem144, 479-494. DOI I
Krop,M., Lu,X., Verdonk,K., Schalekamp,M.A., van Gool,J.M., McKeever,B.M., Gregg,R. and Danser,A.H.
New renin inhibitor VTP-27999 alters renin immunoreactivity and does not unfold prorenin
Hypertension61, 1075-1082. PubMed Europe PubMed DOI I
Lorthiois,E., Breitenstein,W., Cumin,F., Ehrhardt,C., Francotte,E., Jacoby,E., Ostermann,N., Sellner,H., Kosaka,T., Webb,R.L., Rigel,D.F., Hassiepen,U., Richert,P., Wagner,T. and Maibaum,J.
The discovery of novel potent trans-3,4-disubstituted pyrrolidine inhibitors of the human aspartic protease renin from in silico three-dimensional (3D) pharmacophore searches
J Med Chem56, 2207-2217. PubMed Europe PubMed DOI I
Michida,M., Takayanagi,Y., Imai,M., Furuya,Y., Kimura,K., Kitawaki,T., Tomori,H. and Kajino,H.
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Org Process Res Dev17, 1430-1439. DOI I
Mori,Y., Ogawa,Y., Mochizuki,A., Nakamura,Y., Fujimoto,T., Sugita,C., Miyazaki,S., Tamaki,K., Nagayama,T., Nagai,Y., Inoue,S., Chiba,K. and Nishi,T.
Synthesis and optimization of novel (3S,5R)-5-(2,2-dimethyl-5-oxo-4-phenylpiperazin-1-yl)piperidine-3-carboxamides as orally active renin inhibitors
Bioorg Med Chem21, 5907-5922. PubMed Europe PubMed DOI I
Nakamura,Y., Fujimoto,T., Ogawa,Y., Namiki,H., Suzuki,S., Asano,M., Sugita,C., Mochizuki,A., Miyazaki,S., Tamaki,K., Nagai,Y., Inoue,S., Nagayama,T., Kato,M., Chiba,K., Takasuna,K. and Nishi,T.
Lead optimization of 5-amino-6-(2,2-dimethyl-5-oxo-4-phenylpiperazin-1-yl)-4-hydroxyhexanamides to reduce a cardiac safety issue: Discovery of DS-8108b, an orally active renin inhibitor
Bioorg Med Chem21, 3175-3196. PubMed Europe PubMed DOI I
Ostermann,N., Ruedisser,S., Ehrhardt,C., Breitenstein,W., Marzinzik,A., Jacoby,E., Vangrevelinghe,E., Ottl,J., Klumpp,M., Hartwieg,J.C., Cumin,F., Hassiepen,U., Trappe,J., Sedrani,R., Geisse,S., Gerhartz,B., Richert,P., Francotte,E., Wagner,T., Kromer,M., Kosaka,T., Webb,R.L., Rigel,D.F., Maibaum,J. and Baeschlin,D.K.
A novel class of oral direct renin inhibitors: highly potent 3,5-disubstituted piperidines bearing a tricyclic P3-P1 pharmacophore
J Med Chem56, 2196-2206. PubMed Europe PubMed DOI I
Subramanian,G. and Rao,S.N.
Comprehending renin inhibitor's binding affinity using structure-based approaches
Bioorg Med Chem Lett23, 6667-6672. PubMed Europe PubMed DOI I
Subramanian,G.
Computational modeling and design of renin inhibitors
Bioorg Med Chem Lett23, 460-465. PubMed Europe PubMed DOI I

2012

Bras,N.F., Ramos,M.J. and Fernandes,P.A.
The catalytic mechanism of mouse renin studied with QM/MM calculations
Phys Chem Chem Phys14, 12605-12613. PubMed Europe PubMed DOI
Fournier,P.A., Arbour,M., Cauchon,E., Chen,A., Chefson,A., Ducharme,Y., Falgueyret,J.P., Gagne,S., Grimm,E., Han,Y., Houle,R., Lacombe,P., Levesque,J.F., MacDonald,D., Mackay,B., McKay,D., Percival,M.D., Ramtohul,Y., St-Jacques,R. and Toulmond,S.
Design and synthesis of potent, isoxazole-containing renin inhibitors
Bioorg Med Chem Lett22, 2670-2674. PubMed Europe PubMed DOI I
Ishchenko,A., Liu,Z., Lindblom,P., Wu,G., Jim,K.C., Gregg,R.D., Claremon,D.A. and Singh,S.B.
Structure-based design technology contour and its application to the design of renin inhibitors
J Chem Inf Model52, 2089-2097. PubMed Europe PubMed DOI I
Iwai,M., Senba,I., Kanno,H., Nakaoka,H., Inaba,S. and Horiuchi,M.
Renin inhibitors inhibited the activity of recombinant human renin but not activity in healthy human plasma
Clin Lab58, 291-298. PubMed Europe PubMed
Jing,T., Feng,J., Zuo,Y., Ran,B., Liu,J. and He,G.
Exploring the substructural space of indole-3-carboxamide derivatives binding to renin: a novel active-site spatial partitioning approach
J Mol Model18, 4417-4426. PubMed Europe PubMed DOI I
Kunikullaya,U., Ananthakrishnan,V. and Goturu,J.
Robert Tigerstedt and the discovery of renin - a revisit
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Lacombe,P., Arbour,M., Aspiotis,R., Cauchon,E., Chen,A., Dube,D., Falgueyret,J.P., Fournier,P.A., Gallant,M., Grimm,E., Han,Y., Juteau,H., Liu,S., Mellon,C., Ramtohul,Y., Simard,D., St-Jacques,R. and Tsui,G.C.
3,4-Diarylpiperidines as potent renin inhibitors
Bioorg Med Chem Lett22, 1953-1957. PubMed Europe PubMed DOI I
Long,Y., Zhang,L.F., Zhang,Y. and Zhang,C.Y.
Single quantum dot based nanosensor for renin assay
Anal Chem84, 8846-8852. PubMed Europe PubMed DOI A
Morales,R., Watier,Y. and Bocskei,Z.
Human prorenin structure sheds light on a novel mechanism of its autoinhibition and on its non-proteolytic activation by the (pro)renin receptor
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Mori,Y., Ogawa,Y., Mochizuki,A., Nakamura,Y., Sugita,C., Miyazaki,S., Tamaki,K., Matsui,Y., Takahashi,M., Nagayama,T., Nagai,Y., Inoue,S. and Nishi,T.
Design and discovery of new (3S,5R)-5-[4-(2-chlorophenyl)-2,2-dimethyl-5-oxopiperazin-1-yl]piperidine-3-carboxamides as potent renin inhibitors
Bioorg Med Chem Lett22, 7677-7682. PubMed Europe PubMed DOI I
Nakamura,Y., Sugita,C., Meguro,M., Miyazaki,S., Tamaki,K., Takahashi,M., Nagai,Y., Nagayama,T., Kato,M., Suemune,H. and Nishi,T.
Design and optimization of novel (2S,4S,5S)-5-amino-6-(2,2-dimethyl-5-oxo-4-phenylpiperazin-1-yl)-4-hydroxy-2-isopropylhexanamides as renin inhibitors
Bioorg Med Chem Lett22, 4561-4566. PubMed Europe PubMed DOI I
Nakamura,Y., Fujimoto,T., Ogawa,Y., Sugita,C., Miyazaki,S., Tamaki,K., Takahashi,M., Matsui,Y., Nagayama,T., Manabe,K., Mizuno,M., Masubuchi,N., Chiba,K. and Nishi,T.
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ACS Med Chem Lett3, 754-758. PubMed Europe PubMed DOI I
Nurun Nabi,A.H.M., Suzuki,F. and Inagami,T.
Renin
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Udenigwe,C.C., Li,H. and Aluko,R.E.
Quantitative structure-activity relationship modeling of renin-inhibiting dipeptides
Amino Acids42, 1379-1386. PubMed Europe PubMed DOI I
Zhang,J., Preda,D.V., Vasquez,K.O., Morin,J., Delaney,J., Bao,B., Percival,M.D., Xu,D., McKay,D., Klimas,M., Bednar,B., Sur,C., Gao,D.Z., Madden,K., Yared,W., Rajopadhye,M. and Peterson,J.D.
A fluorogenic near-infrared imaging agent for quantifying plasma and local tissue renin activity in vivo and ex vivo
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2011

Al-Nadaf,A.H. and Taha,M.O.
Discovery of new renin inhibitory leads via sequential pharmacophore modeling, QSAR analysis, in silico screening and in vitro evaluation
J Mol Graph Model29, 843-864. PubMed Europe PubMed DOI I
Aspiotis,R., Chen,A., Cauchon,E., Dube,D., Falgueyret,J.P., Gagne,S., Gallant,M., Grimm,E.L., Houle,R., Juteau,H., Lacombe,P., Laliberte,S., Levesque,J.F., MacDonald,D., McKay,D., Percival,M.D., Roy,P., Soisson,S.M. and Wu,T.
The discovery and synthesis of potent zwitterionic inhibitors of renin
Bioorg Med Chem Lett21, 2430-2436. PubMed Europe PubMed DOI I
Beck,B.B., Trachtman,H., Gitman,M., Miller,I., Sayer,J.A., Pannes,A., Baasner,A., Hildebrandt,F. and Wolf,M.T.
Autosomal dominant mutation in the signal peptide of renin in a kindred with anemia, hyperuricemia, and CKD
Am J Kidney Dis58, 821-825. PubMed Europe PubMed DOI M
Brakch,N., Allemandou,F., Keller,I. and Nussberger,J.
The renin prosequence enhances constitutive secretion of renin and optimizes renin activity
Curr Neurovasc Res8, 121-130. PubMed Europe PubMed DOI
Chen,A., Aspiotis,R., Campeau,L.C., Cauchon,E., Chefson,A., Ducharme,Y., Falgueyret,J.P., Gagne,S., Han,Y., Houle,R., Laliberte,S., Larouche,G., Levesque,J.F., McKay,D. and Percival,D.
Renin inhibitors for the treatment of hypertension: design and optimization of a novel series of spirocyclic piperidines
Bioorg Med Chem Lett21, 7399-7404. PubMed Europe PubMed DOI I
Chen,A., Campeau,L.C., Cauchon,E., Chefson,A., Ducharme,Y., Dube,D., Falgueyret,J.P., Fournier,P.A., Gagne,S., Grimm,E., Han,Y., Houle,R., Huang,J.Q., Lacombe,P., Laliberte,S., Levesque,J.F., Liu,S., MacDonald,D., Mackay,B., McKay,D., Percival,M.D., Regan,C., Regan,H., St-Jacques,R. and Toulmond,S.
Renin inhibitors for the treatment of hypertension: design and optimization of a novel series of pyridone-substituted piperidines
Bioorg Med Chem Lett21, 3970-3975. PubMed Europe PubMed DOI I
Chen,A., Cauchon,E., Chefson,A., Dolman,S., Ducharme,Y., Dube,D., Falgueyret,J.P., Fournier,P.A., Gagne,S., Gallant,M., Grimm,E., Han,Y., Houle,R., Huang,J.Q., Hughes,G., Juteau,H., Lacombe,P., Lauzon,S., Levesque,J.F., Liu,S., MacDonald,D., Mackay,B., McKay,D., Percival,M.D., St-Jacques,R. and Toulmond,S.
Renin inhibitors for the treatment of hypertension: design and optimization of a novel series of tertiary alcohol-bearing piperidines
Bioorg Med Chem Lett21, 3976-3981. PubMed Europe PubMed DOI I
Fisher,N.D. and Meagher,E.A.
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J Clin Hypertens (Greenwich)13, 662-666. PubMed Europe PubMed DOI I
Ghasemi,J.B. and Pirhadi,S.
Docking alignment-3D-qsar of a new class of potent and non-chiral indole-3-carboxamide-based renin inhibitors
Collect Czech Chem Commun76, 1447-1469. DOI I
Jia,L., Simpson,R.D., Yuan,J., Xu,Z., Zhao,W., Cacatian,S., Tice,C.M., Guo,J., Ishchenko,A., Singh,S.B., Wu,Z., McKeever,B.M., Bukhtiyarov,Y., Johnson,J.A., Doe,C.P., Harrison,R.K., McGeehan,G.M., Dillard,L.W., Baldwin,J.J. and Claremon,D.A.
Discovery of VTP-27999, an alkyl amine renin inhibitor with potential for clinical utility
ACS Med Chem Lett2, 747-751. PubMed Europe PubMed DOI I
Levesque,J.F., Bleasby,K., Chefson,A., Chen,A., Dube,D., Ducharme,Y., Fournier,P.A., Gagne,S., Gallant,M., Grimm,E., Hafey,M., Han,Y., Houle,R., Lacombe,P., Laliberte,S., MacDonald,D., Mackay,B., Papp,R. and Tschirret-Guth,R.
Impact of passive permeability and gut efflux transport on the oral bioavailability of novel series of piperidine-based renin inhibitors in rodents
Bioorg Med Chem Lett21, 5547-5551. PubMed Europe PubMed DOI I
Matter,H., Scheiper,B., Steinhagen,H., Bocskei,Z., Fleury,V. and McCort,G.
Structure-based design and optimization of potent renin inhibitors on 5- or 7-azaindole-scaffolds
Bioorg Med Chem Lett21, 5487-5492. PubMed Europe PubMed DOI I
Scheiper,B., Matter,H., Steinhagen,H., Bocskei,Z., Fleury,V. and McCort,G.
Structure-based optimization of potent 4- and 6-azaindole-3-carboxamides as renin inhibitors
Bioorg Med Chem Lett21, 5480-5486. PubMed Europe PubMed DOI I
Sun,B., Williams,J.S., Pojoga,L., Chamarthi,B., Lasky-Su,J., Raby,B.A., Hopkins,P.N., Jeunemaitre,X., Brown,N.J., Ferri,C. and Williams,G.H.
Renin gene polymorphism: its relationship to hypertension, renin levels and vascular responses
J Renin Angiotensin Aldosterone Syst12, 564-571. PubMed Europe PubMed DOI M
Sund,C., Belda,O., Wiktelius,D., Sahlberg,C., Vrang,L., Sedig,S., Hamelink,E., Henderson,I., Agback,T., Jansson,K., Borkakoti,N., Derbyshire,D., Eneroth,A. and Samuelsson,B.
Design and synthesis of potent macrocyclic renin inhibitors
Bioorg Med Chem Lett21, 358-362. PubMed Europe PubMed DOI I
Thangapandian,S., John,S., Sakkiah,S. and Lee,K.W.
Potential virtual lead identification in the discovery of renin inhibitors: application of ligand and structure-based pharmacophore modeling approaches
Eur J Med Chem46, 2469-2476. PubMed Europe PubMed DOI I
Wu,Y., Shi,C., Sun,X., Wu,X. and Sun,H.
Synthesis, biological evaluation and docking studies of octane-carboxamide based renin inhibitors with extended segments toward S3' site of renin
Bioorg Med Chem19, 4238-4249. PubMed Europe PubMed DOI I
Yuan,J., Simpson,R.D., Zhao,W., Tice,C.M., Xu,Z., Cacatian,S., Jia,L., Flaherty,P.T., Guo,J., Ishchenko,A., Wu,Z., McKeever,B.M., Scott,B.B., Bukhtiyarov,Y., Berbaum,J., Panemangalore,R., Bentley,R., Doe,C.P., Harrison,R.K., McGeehan,G.M., Singh,S.B., Dillard,L.W., Baldwin,J.J. and Claremon,D.A.
Biphenyl/diphenyl ether renin inhibitors: filling the S1 pocket of renin via the S3 pocket
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2010

Azizi,M. and Menard,J.
Review: measurement of plasma renin: a critical review of methodology
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Bleyer,A.J., Zivna,M., Hulkova,H., Hodanova,K., Vyletal,P., Sikora,J., Zivny,J., Sovova,J., Hart,T.C., Adams,J.N., Elleder,M., Kapp,K., Haws,R., Cornell,L.D., Kmoch,S. and Hart,P.S.
Clinical and molecular characterization of a family with a dominant renin gene mutation and response to treatment with fludrocortisone
Clin Nephrol74, 411-422. PubMed Europe PubMed M
Castrop,H., Hocherl,K., Kurtz,A., Schweda,F., Todorov,V. and Wagner,C.
Physiology of kidney renin
Physiol Rev90, 607-673. PubMed Europe PubMed DOI V
Chen,A., Dube,D., Dube,L., Gagne,S., Gallant,M., Gaudreault,M., Grimm,E., Houle,R., Lacombe,P., Laliberte,S., Liu,S., MacDonald,D., Mackay,B., Martin,D., McKay,D., Powell,D. and Levesque,J.F.
Addressing time-dependent CYP 3A4 inhibition observed in a novel series of substituted amino propanamide renin inhibitors, a case study
Bioorg Med Chem Lett20, 5074-5079. PubMed Europe PubMed DOI I
Chen,A., Bayly,C., Bezencon,O., Richard-Bildstein,S., Dube,D., Dube,L., Gagne,S., Gallant,M., Gaudreault,M., Grimm,E., Houle,R., Lacombe,P., Laliberte,S., Levesque,J.F., Liu,S., MacDonald,D., Mackay,B., Martin,D., McKay,D., Powell,D., Remen,L., Soisson,S. and Toulmond,S.
Design and optimization of a substituted amino propanamide series of renin inhibitors for the treatment of hypertension
Bioorg Med Chem Lett20, 2204-2209. PubMed Europe PubMed DOI I
Corminboeuf,O., Bezencon,O., Grisostomi,C., Remen,L., Richard-Bildstein,S., Bur,D., Prade,L., Hess,P., Strickner,P., Fischli,W., Steiner,B. and Treiber,A.
Design and optimization of new piperidines as renin inhibitors
Bioorg Med Chem Lett20, 6286-6290. PubMed Europe PubMed DOI I
Corminboeuf,O., Bezencon,O., Remen,L., Grisostomi,C., Richard-Bildstein,S., Bur,D., Prade,L., Strickner,P., Hess,P., Fischli,W., Steiner,B. and Treiber,A.
Piperidine-based renin inhibitors: upper chain optimization
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Gotoh,T., Kikuchi,K.I. and Takahashi,S.
Active human renin production using a baculovirus expression vector system: an effective method for preventing excessive proteolytic degradation of recombinant proteins
J Chem Eng Jpn43, 603-607. DOI E
Gross,K.W., Gomez,R.A. and Sigmund,C.D.
Twists and turns in the search for the elusive renin processing enzyme: focus on "Cathepsin B is not the processing enzyme for mouse prorenin"
Am J Physiol Regul Integr Comp Physiol298, R1209-R1211. PubMed Europe PubMed DOI
Israili,Z.H., Velasco,M. and Bermudez,V.
Direct renin inhibitors as antihypertensive agents
Am J Ther17, 237-254. PubMed Europe PubMed DOI V I
Lacombe,P., Aspiotis,R., Bayly,C., Chen,A., Dube,D., Fortin,R., Gallant,M., Juteau,H., Liu,S., McKay,D., Roy,P. and Wu,T.
Identification of a new biaryl scaffold generating potent renin inhibitors
Bioorg Med Chem Lett20, 5822-5826. PubMed Europe PubMed DOI I
Mercure,C., Lacombe,M.J., Khazaie,K. and Reudelhuber,T.L.
Cathepsin B is not the processing enzyme for mouse prorenin
Am J Physiol Regul Integr Comp Physiol298, R1212-R1216. PubMed Europe PubMed DOI K
Scheiper,B., Matter,H., Steinhagen,H., Stilz,U., Bocskei,Z., Fleury,V. and McCort,G.
Discovery and optimization of a new class of potent and non-chiral indole-3-carboxamide-based renin inhibitors
Bioorg Med Chem Lett20, 6268-6272. PubMed Europe PubMed DOI I
Takahashi,S., Tokiwano,T., Hata,K., Kodama,I., Hokari,M., Suzuki,N., Yoshizawa,Y. and Gotoh,T.
The occurrence of renin inhibitor in rice: isolation, identification, and structure-function relationship
Biosci Biotechnol Biochem74, 1713-1715. PubMed Europe PubMed DOI I
Webb,R.L., Schiering,N., Sedrani,R. and Maibaum,J.
Direct renin inhibitors as a new therapy for hypertension
J Med Chem53, 7490-7520. PubMed Europe PubMed DOI V I
Winiecka,I., Dudkiewicz-Wilczynska,J., Roman,I. and Paruszewski,R.
New potential renin inhibitors with dipeptide replacements in the molecule
Acta Pol Pharm67, 367-374. PubMed Europe PubMed I

2009

Bezencon,O., Bur,D., Weller,T., Richard-Bildstein,S., Remen,L., Sifferlen,T., Corminboeuf,O., Grisostomi,C., Boss,C., Prade,L., Delahaye,S., Treiber,A., Strickner,P., Binkert,C., Hess,P., Steiner,B. and Fischli,W.
Design and preparation of potent, nonpeptidic, bioavailable renin inhibitors
J Med Chem52, 3689-3702. PubMed Europe PubMed DOI I
Kher,V.
Renin inhibition - benefit beyond hypertension control
J Assoc Physicians India57, 518-520. PubMed Europe PubMed I
Nabi,A.H., Biswas,K.B., Nakagawa,T., Ichihara,A., Inagami,T. and Suzuki,F.
Prorenin has high affinity multiple binding sites for (pro)renin receptor
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Pinto,R. and Gradman,A.H.
Direct renin inhibition: an update
Curr Hypertens Rep11, 456-462. PubMed Europe PubMed DOI V I
Remen,L., Bezencon,O., Richard-Bildstein,S., Bur,D., Prade,L., Corminboeuf,O., Boss,C., Grisostomi,C., Sifferlen,T., Strickner,P., Hess,P., Delahaye,S., Treiber,A., Weller,T., Binkert,C., Steiner,B. and Fischli,W.
New classes of potent and bioavailable human renin inhibitors
Bioorg Med Chem Lett19, 6762-6765. PubMed Europe PubMed DOI I
Riccioni,G., Vitulano,N., D'Orazio,N. and Bellocci,F.
Aliskiren, the first approved renin inhibitor: clinical application and safety in the treatment of hypertension
Adv Ther26, 700-710. PubMed Europe PubMed DOI I
Sanoski,C.A.
Aliskiren: an oral direct renin inhibitor for the treatment of hypertension
Pharmacotherapy29, 193-212. PubMed Europe PubMed DOI I
Tice,C.M., Xu,Z., Yuan,J., Simpson,R.D., Cacatian,S.T., Flaherty,P.T., Zhao,W., Guo,J., Ishchenko,A., Singh,S.B., Wu,Z., Scott,B.B., Bukhtiyarov,Y., Berbaum,J., Mason,J., Panemangalore,R., Cappiello,M.G., Muller,D., Harrison,R.K., McGeehan,G.M., Dillard,L.W., Baldwin,J.J. and Claremon,D.A.
Design and optimization of renin inhibitors: orally bioavailable alkyl amines
Bioorg Med Chem Lett19, 3541-3545. PubMed Europe PubMed DOI I
Yamaguchi,Y., Menear,K., Cohen,N.C., Mah,R., Cumin,F., Schnell,C., Wood,J.M. and Maibaum,J.
The P1 N-isopropyl motif bearing hydroxyethylene dipeptide isostere analogues of aliskiren are in vitro potent inhibitors of the human aspartyl protease renin
Bioorg Med Chem Lett19, 4863-4867. PubMed Europe PubMed DOI I

2008

Dockery,B.K. and Bisognano,J.D.
Direct renin inhibition: an analysis of possible benefits
Curr Hypertens Rep10, 313-318. PubMed Europe PubMed DOI T I
Iwata,H., Nakagawa,T., Yoshioka,Y., Kagei,K., Imada,K., Nakane,C., Fujita,H., Suzuki,F. and Nakamura,Y.
The coexistence of Ser84 in renin and His13 in angiotensinogen brings a pH profile of two separate peaks to the reaction of human renin and sheep angiotensinogen
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Jensen,C., Herold,P. and Brunner,H.R.
Aliskiren: the first renin inhibitor for clinical treatment
Nat Rev Drug Discov7, 399-410. PubMed Europe PubMed DOI I
Major,T.C., Olszewski,B., Rosebury,W., Okerberg,C., Carlson,T., Ostroski,R., Schroeder,R., Kowala,M.C. and Leadley,R.
A nonpeptide, piperidine renin inhibitor provides renal and cardiac protection in double-transgenic mice expressing human renin and angiotensinogen genes
Cardiovasc Drugs Ther22, 469-478. PubMed Europe PubMed DOI I
Schefe,J.H., Neumann,C., Goebel,M., Danser,J., Kirsch,S., Gust,R., Kintscher,U., Unger,T. and Funke-Kaiser,H.
Prorenin engages the (pro)renin receptor like renin and both ligand activities are unopposed by aliskiren
J Hypertens26, 1787-1794. PubMed Europe PubMed DOI I
Takahashi,S., Hori,K., Shinbo,M., Hiwatashi,K., Gotoh,T. and Yamada,S.
Isolation of human renin inhibitor from soybean: soyasaponin I is the novel human renin inhibitor in soybean
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Uddin,M.N., Nabi,A.H., Nakagawa,T., Ichihara,A., Inagami,T. and Suzuki,F.
Non-proteolytic activation of prorenin: activation by (pro)renin receptor and its inhibition by a prorenin prosegment, "decoy peptide"
Front Biosci13, 745-753. PubMed Europe PubMed DOI V
Wu,Z., Cappiello,M.G., Scott,B.B., Bukhtiyarov,Y. and McGeehan,G.M.
Purification and characterization of recombinant human renin for X-Ray crystallization studies
BMC Biochem9, 19-19. PubMed Europe PubMed DOI E

2007

Achard,V., Boullu-Ciocca,S., Desbriere,R., Nguyen,G. and Grino,M.
Renin receptor expression in human adipose tissue
Am J Physiol Regul Integr Comp Physiol292, R274-R282. PubMed Europe PubMed DOI
Brown,M.J.
Renin: friend or foe?
Heart93, 1026-1033. PubMed Europe PubMed DOI V
Bukhtiyarov,Y., Zecher,M., Panemangalore,R., Wu,Z., Bruno,J.G., Yuan,J., Xu,Z., Dillard,L.W., McGeehan,G.M., Harrison,R.K. and Scott,B.B.
Cloning, characterization and site-directed mutagenesis of canine renin
J Biochem142, 671-680. PubMed Europe PubMed DOI
Dechend,R., Shagdarsuren,E., Gratze,P., Fiebeler,A., Pilz,B., Meiners,S., Derer,W., Feldman,D.L., Webb,R. and Muller,D.N.
Low-dose renin inhibitor and low-dose AT(1)-receptor blocker therapy ameliorate target-organ damage in rats harbouring human renin and angiotensinogen genes
J Renin Angiotensin Aldosterone Syst8, 81-84. PubMed Europe PubMed DOI I
Goschke,R., Stutz,S., Rasetti,V., Cohen,N.C., Rahuel,J., Rigollier,P., Baum,H.P., Forgiarini,P., Schnell,C.R., Wagner,T., Gruetter,M.G., Fuhrer,W., Schilling,W., Cumin,F., Wood,J.M. and Maibaum,J.
Novel 2,7-dialkyl-substituted 5(S)-amino-4(S)-hydroxy-8-phenyl-octanecarboxamide transition state peptidomimetics are potent and orally active inhibitors of human renin
J Med Chem50, 4818-4831. PubMed Europe PubMed DOI I
Holsworth,D.D., Jalaie,M., Belliotti,T., Cai,C., Collard,W., Ferreira,S., Powell,N.A., Stier,M., Zhang,E., McConnell,P., Mochalkin,I., Ryan,M.J., Bryant,J., Li,T., Kasani,A., Subedi,R., Maiti,S.N. and Edmunds,J.J.
Discovery of 6-ethyl-2,4-diaminopyrimidine-based small molecule renin inhibitors
Bioorg Med Chem Lett17, 3575-3580. PubMed Europe PubMed DOI I
Konoshita,T., Fuchs,S., Makino,Y., Wakahara,S. and Miyamori,I.
A proximal direct repeat motif characterized as a negative regulatory element in the human renin gene
J Cell Biochem102, 1043-1050. PubMed Europe PubMed DOI
Leibovitz,E. and Schiffrin,E.L.
Novel drugs targeting hypertension: renin inhibitors and beyond
J Cardiovasc Pharmacol50, 3-8. PubMed Europe PubMed DOI V I
Li,Y.C.
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Azizi,M.
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Fisher,N.D. and Hollenberg,N.K.
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2004

Hansen,P.B., Yang,T., Huang,Y., Mizel,D., Briggs,J. and Schnermann,J.
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Nguyen,G., Burckle,C.A. and Sraer,J.D.
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Lavoie,J.L. and Sigmund,C.D.
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2002

[YEAR:11-6-2002]Caron,K.M., James,L.R., Kim,H.S., Morham,S.G., Sequeira Lopez,M.L., Gomez,R.A., Reudelhuber,T.L. and Smithies,O.
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Fuchs,S., Germain,S., Philippe,J., Corvol,P. and Pinet,F.
Expression of renin in large arteries outside the kidney revealed by human renin promoter/LacZ transgenic mouse
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Prescott,G., Silversides,D.W. and Reudelhuber,T.L.
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Yabuki,A., Suzuki,S., Matsumoto,M., Taniguchi,K. and Nishinakagawa,H.
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2001

Leckie,B.J.
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2000

Rahuel,J., Rasetti,V., Maibaum,J., Rueger,H., Goschke,R., Cohen,N.C., Stutz,S., Cumin,F., Fuhrer,W., Wood,J.M. and Grutter,M.G.
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Zimmerman,B.G.
Greater blood pressure-lowering effect of the renin inhibitor EMD 58265 than an angiotensin-converting enzyme inhibitor in two-kidney one-clip Goldblatt rabbit
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1999

Admiraal,P.J., van Kesteren,C.A., Danser,A.H., Derkx,F.H., Sluiter,W. and Schalekamp,M.A.
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Human renin gene BglI dimorphism associated with hypertension in two independent populations
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Germain,S., Bonnet,F., Fuchs,S., Philippe,J., Corvol,P. and Pinet,F.
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Nasir,U.M., Suzuki,F., Nagai,T., Nakagawa,T. and Nakamura,Y.
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1998

[YEAR:10-11-1998]Deinum,J., Derkx,F.H. and Schalekamp,M.A.
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A novel distal enhancer confers chorionic expression on the human renin gene
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Inagami,T.
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1997

Salzet,M. and Stefano,G.
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Tokarski,J.S. and Hopfinger,A.J.
Prediction of ligand-receptor binding thermodynamics by free energy force field (FEFF) 3D-QSAR analysis: application to a set of peptidometic renin inhibitors
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1996

De Vito,E., Martinez de Melian,E.R. and Guardia,D.C.
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Mathews,S., Dobeli,H., Pruschy,M., Bosser,R., D'arcy,A., Oefner,C., Zulauf,M., Gentz,R., Breu,V., Matile,H., Schlaeger,J. and Fischli,W.
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1995

Aguilar,C.F., Dhanaraj,V., Guruprasad,K., Dealwis,C., Badasso,M., Cooper,J.B., Wood,S.P. and Blundell,T.L.
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1994

Hatae,T., Takimoto,E., Murakami,K. and Fukamizu,A.
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1993

Rao,C., Scarborough,P.E., Lowther,W.T., Kay,J., Batley,B., Rapundalo,S., Klutchko,S., Taylor,M.D. and Dunn,B.M.
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1992

[YEAR:15-11-1992]Derkx,F.H., Deinum,J., Lipovski,M., Verhaar,M., Fischli,W. and Schalekamp,M.A.
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1991

Doi,M., In,Y., Inoue,M., Ishida,T., Iizuka,K., Akahane,K., Harada,H., Umeyama,H. and Kiso,Y.
Conformational study of a potent human renin inhibitor: X-ray crystal structure of isopropyl (2R,3S)-4-cyclohexyl- 2- hydroxy-3-{N-[(2R)-2-morpholinocarbonylmethyl-3-(1- naphthyl)propionyl]-L-histidylamino}butyrate (KRI-1314), a pentapeptide analogue with amino acid sequence corresponding to the cleavage site of angiotensinogen
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Fischli,W., Clozel,J.P., el Amrani,K., Wostl,W., Neidhart,W., Stadler,H. and Branca,Q.
Ro 42-5892 is a potent orally active renin inhibitor in primates
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Pravenec,M., Simonet,L., Kren,V., Kunes,J., Levan,G., Szpirer,J., Szpirer,C. and Kurtz,T.
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The crystal structures of recombinant glycosylated human renin alone and in complex with a transition state analog inhibitor
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1990

Glassman,H.N., Kleinert,H.D., Boger,R.S., Moyse,D.M., Griffiths,A.N. and Luther,R.R.
Clinical pharmacology of enalkiren, a novel, dipeptide renin inhibitor
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Substrate specificity of recombinant human renal renin: effect of histidine in the P2 subsite on pH dependence
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A practical synthesis of an orally potent renin inhibitor, isopropyl (2R,3S)-4-cyclohexyl-2-hydroxy-3-{N-[(2R)-2-morpholinocarbonylmethyl-3-(1- naphthyl)propionyl]-L-histidyl}aminobutyrate
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Iizuka,K., Kamijo,T., Harada,H., Akahane,K., Kubota,T., Umeyama,H., Ishida,T. and Kiso,Y.
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Ohkubo,H., Kawakami,H., Kakehi,Y., Takumi,T., Arai,H., Yokota,Y., Iwai,M., Tanabe,Y., Masu,M. and Hata,J.
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Shiratori,Y., Nakagawa,S., Hori,H., Murakami,K. and Umeyama,H.
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Thaisrivongs,S., Mao,B., Pals,D.T., Turner,S.R. and Kroll,L.T.
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Yamauchi,T., Nagahama,M., Watanabe,T., Ishizuka,Y., Hori,H. and Murakami,K.
Site-directed mutagenesis of human prorenin. Substitution of three arginine residues in the propeptide with glutamine residues yields active prorenin
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1989

[YEAR:5-5-1989]Burt,D.W., Nakamura,N., Kelley,P. and Dzau,V.J.
Identification of negative and positive regulatory elements in the human renin gene
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Sielecki,A.R., Hayakawa,K., Fujinaga,M., Murphy,M.E., Fraser,M., Muir,A.K., Carilli,C.T., Lewicki,J.A., Baxter,J.D. and James,M.N.
Structure of recombinant human renin, a target for cardiovascular-active drugs, at 2.5 A resolution
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Wood,J.M., Criscione,L., de Gasparo,M., Buhlmayer,P., Rueger,H., Stanton,J.L., Jupp,R.A. and Kay,J.
CGP 38 560: orally active, low-molecular-weight renin inhibitor with high potency and specificity
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1988

Yamauchi,T., Nagahama,M., Hori,H. and Murakami,K.
Functional characterization of Asp-317 mutant of human renin expressed in COS cells
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1987

Bolis,G., Fung,A.K., Greer,J., Kleinert,H.D., Marcotte,P.A., Perun,T.J., Plattner,J.J. and Stein,H.H.
Renin inhibitors. Dipeptide analogues of angiotensinogen incorporating transition-state, nonpeptidic replacements at the scissile bond
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Burnham,C.E., Hawelu-Johnson,C.L., Frank,B.M. and Lynch,K.R.
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Characterization of pure human renal renin. Evidence for a subunit structure
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Hui,K.Y., Carlson,W.D., Bernatowicz,M.S. and Haber,E.
Analysis of structure-activity relationships in renin substrate analogue inhibitory peptides
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Kempf,D.J., de Lara,E., Stein,H.H., Cohen,J. and Plattner,J.J.
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Pinet,F., Mizrahi,J., Laboulandine,I., Menard,J. and Corvol,P.
Regulation of prorenin secretion in cultured human transfected juxtaglomerular cells
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Takada,Y., Maruta,H., Wagner,B., FA,X.G., James,H.L. and Erdos,E.G.
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1986

Poorman,R.A., Palermo,D.P., Post,L.E., Murakami,K., Kinner,J.H., Smith,C.W., Reardon,I. and Heinrikson,R.L.
Isolation and characterization of native human renin derived from Chinese hamster ovary cells
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Soubrier,F., Panthier,J.J., Houot,A.M., Rougeon,F. and Corvol,P.
Segmental homology between the promoter region of the human renin gene and the mouse ren1 and ren2 promoter regions
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1985

Boger,J.
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Renin inhibitors. Syntheses of subnanomolar, competitive, transition-state analogue inhibitors containing a novel analogue of statine
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Inhibition of human renin by synthetic peptides derived from its prosegment
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Szelke,M., Tree,M., Leckie,B.J., Jones,D.M., Atrash,B., Beattie,S., Donovan,B., Hallett,A., Hughes,M. and Lever,A.F.
A transition-state analogue inhibitor of human renin (H.261): test in vitro and a comparison with captopril in the anaesthetized baboon
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Webb,D.J., Manhem,P.J., Ball,S.G., Inglis,G., Leckie,B.J., Lever,A.F., Morton,J.J., Robertson,J.I., Murray,G.D. and Menard,J.
A study of the renin inhibitor H142 in man
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1984

Chirgwin,J.M., Schaefer,I.M., Rotwein,P.S., Piccini,N., Gross,K.W. and Naylor,S.L.
Human renin gene is on chromosome 1
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Haber,E.
The first Sir George Pickering memorial lecture. Which inhibitors will give us true insight into what renin really does?
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Hardman,J.A., Hort,Y.J., Catanzaro,D.F., Tellam,J.T., Baxter,J.D., Morris,B.J. and Shine,J.
Primary structure of the human renin gene
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Miyazaki,H., Fukamizu,A., Hirose,S., Hayashi,T., Hori,H., Ohkubo,H., Nakanishi,S. and Murakami,K.
Structure of the human renin gene
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Pandey,K.N., Melner,M.H., Parmentier,M. and Inagami,T.
Demonstration of renin activity in purified rat Leydig cells: evidence for the existence of an endogenous inactive (latent) form of enzyme
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Renin cleavage of a human kidney renin substrate analogous to human angiotensinogen, H-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Ser-OH, that is human renin specific and is resistant to cathepsin D
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1983

[YEAR:5-5-1983]Boger,J., Lohr,N.S., Ulm,E.H., Poe,M., Blaine,E.H., Fanelli,G.M., Lin,T.Y., Payne,L.S., Schorn,T.W., LaMont,B.I., Vassil,T.C., Stabilito,I.I., Veber,D.F., Rich,D.H. and Bopari,A.S.
Novel renin inhibitors containing the amino acid statine
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Purification of human renin by affinity chromatography using a new peptide inhibitor of renin, H.77 (D-His-Pro-Phe-His-LeuR-Leu-Val-Tyr)
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Tree,M., Atrash,B., Donovan,B., Gamble,J., Hallett,A., Hughes,M., Jones,D.M., Leckie,B., Lever,A.F. and Morton,J.J.
New inhibitors of human renin tested in vitro and in vivo in the anaesthetized baboon
J Hypertens1, 399-403. PubMed Europe PubMed I
Webb,D.J., Cumming,A.M., Leckie,B.J., Lever,A.F., Morton,J.J., Robertson,J.I., Szelke,M. and Donovan,B.
Reduction of blood pressure in man with H-142, a potent new renin inhibitor
Lancet2, 1486-1487. PubMed Europe PubMed I

1982

Mullins,J.J., Burt,D.W., Windass,J.D., McTurk,P., George,H. and Brammar,W.J.
Molecular cloning of two distinct renin genes from the DBA/2 mouse
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Ondetti,M.A. and Cushman,D.W.
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Potent new inhibitors of human renin
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[YEAR:15-1-1982]Takii,Y. and Inagami,T.
Purification of a completely inactive renin from hog kidney and identification as renin zymogen
Biochem Biophys Res Commun104, 133-140. PubMed Europe PubMed

1981

[YEAR:1-8-1981]Eid,M., Evin,G., Castro,B., Menard,J. and Corvol,P.
New renin inhibitors homologous with pepstatin
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New fluorogenic substrates for renin
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Slater,E.E. and Strout,H.V., Jr.
Pure human renin. Identification and characterization of two major molecular weight forms
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Slater,E.E.
Renin
Methods Enzymol80, 427-442. PubMed Europe PubMed DOI V

1980

[YEAR:17-11-1980]Cody,R.J., Burton,J., Evin,G., Poulsen,K., Herd,J.A. and Haber,E.
A substrate analog inhibitor of renin that is effective in vivo
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Conio,G., Ghiani,P., Patrone,E., Trefiletti,V., Uva,B. and Vallarino,M.
Isolation and characterization of multiple forms of renin from bull kidney
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Johnson,R.L. and Poisner,A.M.
Inactivation of amniotic prorenin by ethyl diazoacetylglycinate
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1979

[YEAR:10-6-1979]Galen,F.X., Devaux,C., Guyenne,T., Menard,J. and Corvol,P.
Multiple forms of human renin. Purification and characterization
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Marks,L.S. and Maxwell,M.H.
Tigerstedt and the discovery of renin. An historical note
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Poulsen,K., Vuust,J., Lykkegaard,S., Nielsen,A.H. and Lund,T.
Renin is synthesized as a 50,000 dalton single-chain polypeptide in cell-free translation systems
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1978

Evin,G., Gardes,J., Kreft,C., Castro,B., Corvol,P. and Menard,J.
Soluble pepstatins: a new approach to blockade in vivo of the renin-angiotensin system
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Rat renin: purification and characterization
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Miyazaki,M., Okunishi,H., Komori,T. and Yamamoto,K.
Renin inhibitory effect of N-acetyl-pepstatin
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1977

Corvol,P., Devaux,C., Ito,T., Sicard,P., Ducloux,J. and Menard,J.
Large scale purification of hog renin. Physicochemical characterization
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Inagami,T. and Murakami,K.
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Inagami,T., Murakami,K., Misono,K., Workman,R.J., Cohen,S. and Suketa,Y.
Renin and precursors: purification, characterization, and studies on active site
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1976

Lentz,K.E., Skeggs,L.T., Dorer,F.E., Kahn,J.R. and Levine,M.
A new radiolabeled protein renin substrate
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Swales,J.D., Amery,A., Lijnen,P., Fagard,R. and Reybrouck,T.
Inactive renin in human plasma
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1975

[YEAR:26-8-1975]Burton,J., Poulsen,K. and Haber,E.
Competitive inhibitors of renin. Inhibitors effective at physiological pH
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Human renin inhibition by a diazoacyl reagent: relationship of the enzyme to other proteinases
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1974

[YEAR:25-12-1974]McKown,M.M., Workman,R.J. and Gregerman,R.I.
Pepstatin inhibition of human renin. Kinetic studies and estimation of enzyme purity
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1973

[YEAR:15-10-1973]Parikh,I. and Cuatrecasas,P.
Substrate analog competitive inhibitors of human renin
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Competitive inhibitors of renin
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1972

Gross,F., Lazar,J. and Orth,H.
Inhibition of the renin-angiotensinogen reaction by pepstatin
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1970

Smeby,R.R. and Bumpus,F.M.
[51] Renin
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1969

Reinharz,A. and Roth,M.
Studies on renin with synthetic substrates
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1968

[YEAR:1-7-1968]Skeggs,L.T., Lentz,K.E., Kahn,J.R. and Hochstrasser,H.
Kinetics of the reaction of renin with nine synthetic peptide substrates
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1965

Arakawa,K., Nakatani,M. and Nakamura,M.
Species specificity in reaction between renin and angiotensinogen
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1964

Mazur,R.H. and Schlatter,J.M.
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1962

Kemp,E. and Rubin,I.
Renin purification by DEAE cellulose chromatography
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1942

Schales,O.
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1941

Wakerlin,G.E., Johnson,C.A., Gomberg,B. and Goldberg,M.L.
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1940

Braun-Menendez,E., Fasciolo,J.C., Leloir,L.F. and Munoz,J.M.
The substance causing renal hypertension
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A CRYSTALLINE PRESSOR SUBSTANCE (ANGIOTONIN) RESULTING FROM THE REACTION BETWEEN RENIN AND RENIN-ACTIVATOR
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1898

Tigerstedt,R. and Bergmann,P.
Niere und kreislauf
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1890

Lea,A.S. and Dickinson,W.L.
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1840

Deschamps,J.B.
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