Merops Switch to
Inhibitors

Peptidase

Family Clan SEARCHES BLAST
MEROPS SUBMISSIONS

Other
information

Literature for peptidase A01.007: renin

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

(Topics flags: A Assay, S Structure, T Target, P Specificity, K Knockout, E Expression, V Review, M Mutation, I Inhibitor, L Localization. To select only the references relevant to a single topic, click the link above. See explanation.)

    2026
  1. Wu,L., Zhang,B., Zhang,Y., Yang,S., Shi,C., Wang,W., Fang,Z., Zhang,L. and Qin,X.
    Evaluation of the MAGLUMI non-competitive angiotensin I chemiluminescence immunoassay for measuring renin activity in human plasma
    Clin Chem Lab Med (2026) PubMed  Europe PubMed DOI
    2. 2025
  2. Adhikari,A., Sharma,C., Lhamu Sherpa,M., Karaunakran,G., Dhakal,M. and Sharma,A.
    Impact of Renin-Angiotensin-Aldosterone System (RAAS) Gene Polymorphism in Essential Hypertension and Antihypertensive Drug Therapy: A Review
    Int J Hypertens (2025) 2025, 5530265-5530265. PubMed  Europe PubMed DOI  PMC  EPMC  V
  3. Akkan,C., Das,M., Bardakci,O., Sehitoglu,M.H., Akdur,G., Akman,C., Akdur,O. and Beyazit,Y.
    A prediction model for lung involvement using circulating angiotensin converting enzyme-2 and renin levels in COVID-19 patients
    J Infect Dev Ctries (2025) 19, 1432-1442. PubMed  Europe PubMed DOI
  4. Hill,R.Z., Nelson,J.W., Gyarmati,G., Medrano,S., Shirvan,S., McCormick,J.A., Burquez,S., Ahmed,J., Eng,D.G., Wysocki,J., Dubin,A.E., Servin-Vences,M.R., Lakshmanan,A., Gomez,R.A., Sequeira-Lopez,M.L.S., Shankland,S.J., Batlle,D., Miner,J.H., Peti-Peterdi,J. and Patapoutian,A.
    Renal PIEZO2 is an essential regulator of renin
    Cell (2025) PubMed  Europe PubMed DOI  PMC  EPMC
  5. Nunez,F.F., Siqueiros-Marquez,L., Adan-Castro,E., Zamora,M., Robles,J.P., Ruiz-Herrera,X., Bertsch,T., Triebel,J., Martinez de la Escalera,G. and Clapp,C.
    Vasoinhibin is generated by the Renin-Angiotensin System
    Endocrinology (2025) PubMed  Europe PubMed DOI
  6. Sealey,J.E. and Blumenfeld,J.D.
    Maintenance of blood pressure by reactive increases in plasma renin activity during salt depletion and renin-angiotensin system inhibition
    J Hypertens (2025) 43, 1457-1457. PubMed  Europe PubMed DOI  PMC  EPMC
  7. Trerattanavong,K. and Chen,J.
    Biochemistry, Renin
     (2025) PubMed  Europe PubMed
  8. Valiente,P.A., Guerra,Y., Wolf,M.G., Pascual,I., Rudino-Pinera,E., Florent,I., Pons,T. and Groenhof,G.
    Discovery of a Noncompetitive Open-Flap Selective Inhibitor of Plasmepsin II with Antiplasmodial Activity
    J Chem Inf Model (2025) PubMed  Europe PubMed DOI  I
  9. Wieruszewski,P.M.
    Renin Is an Important Prognostic and Predictive Biomarker in Cardiac Surgery-associated Acute Kidney Injury
    J Cardiothorac Vasc Anesth (2025) PubMed  Europe PubMed DOI
    10. 2024
  10. Chakradhar,A., Baron,R.M., Vera,M.P., Devarajan,P., Chawla,L. and Hou,P.C.
    Plasma renin as a novel prognostic biomarker of sepsis-associated acute respiratory distress syndrome
    Sci Rep (2024) 14, 6667-6667. PubMed  Europe PubMed DOI  PMC  EPMC  V
  11. Kotani,Y., Belletti,A., Maiucci,G., Lodovici,M., Fresilli,S., Landoni,G., Bellomo,R. and Zarbock,A.
    Renin as a Prognostic Marker in Intensive Care and Perioperative Settings: A Scoping Review
    Anesth Analg (2024) 138, 929-936. PubMed  Europe PubMed DOI  V
  12. Kotani,Y., Chappell,M., Landoni,G., Zarbock,A., Bellomo,R. and Khanna,A.K.
    Renin in critically ill patients
    Ann Intensive Care (2024) 14, 79-79. PubMed  Europe PubMed DOI  PMC  EPMC  V
  13. Schalekamp,M.A.D.H., Deinum,J. and Danser,A.H.J.
    Short-Lived Active Prorenin: Precursor of So-Called Native Prorenin
    Hypertension (2024) 81, 1190-1193. PubMed  Europe PubMed DOI  PMC  EPMC
  14. Shen,Y., Lotenberg,K., Zaworski,J., Broeker,K.A., Vasseur,F., Louedec,L., Placier,S., Frere,P., Verpont,M.C., Galichon,P., Buob,D., Hadchouel,J., Terzi,F., Chatziantoniou,C. and Calmont,A.
    Neuropilin-1 regulates renin synthesis in juxtaglomerular cells
    J Physiol (2024) 602, 1815-1833. PubMed  Europe PubMed DOI
  15. Triebel,H. and Castrop,H.
    The renin angiotensin aldosterone system
    Pflugers Arch (2024) 476, 705-713. PubMed  Europe PubMed DOI  V
  16. Zhang,Y., Martin,B., Spies,M.A., Roberts,S.M., Nott,J., Goodfellow,R.X., Nelson,A.F.M., Blain,S.J., Redondo,E., Nester,C.M. and Smith,R.J.H.
    Renin and renin blockade have no role in complement activity
    Kidney Int (2024) 105, 328-337. PubMed  Europe PubMed DOI  PMC  EPMC
    17. 2023
  17. Akther,J., Nabi,A.H.M.N., Ohno,S., Yokogawa,T., Nakagawa,T., Suzuki,F. and Ebihara,A.
    Corrigendum to "establishing a novel assay system for measuring renin concentration using cost effective recombinant ovine angiotensinogen"
    Heliyon (2023) 9, e13123-e13123. PubMed  Europe PubMed DOI  PMC  EPMC
  18. Loganathan,L., Sankar,J., Rajendran,K. and Muthusamy,K.
    Theoretical investigation on known renin inhibitors and generation of ligand-based pharmacophore models for hypertension treatment
    J Biomol Struct Dyn (2023) , 1-10. PubMed  Europe PubMed DOI
  19. Moguel-Concha,D.D.R., Borges-Martinez,J.E., Cid-Gallegos,M.S., Juarez-Chairez,M.F., Gomez-Gomez,A.L., Tellez-Medina,D.I. and Jimenez-Martinez,C.
    Antioxidant and Renin Inhibitory Activities of Peptides from Food Proteins on Hypertension: A Review
    Plant Foods Hum Nutr (2023) 78, 493-505. PubMed  Europe PubMed DOI  V
  20. Ostrowski,J. and Kurkus,J.
    Robert Tigerstedt and the Discovery of Renin
    Exp Clin Transplant (2023) 21, 62-66. PubMed  Europe PubMed DOI
  21. Wang,C., Wang,Z., Xu,J., Ma,H., Jin,K., Xu,T., Pan,X., Feng,X. and Zhang,W.
    C3aR Antagonist Alleviates C3a Induced Tubular Profibrotic Phenotype Transition via Restoring PPARalpha/CPT-1alpha Mediated Mitochondrial Fatty Acid Oxidation in Renin-Dependent Hypertension
    Front Biosci (Landmark Ed) (2023) 28, 238-238. PubMed  Europe PubMed DOI
    22. 2022
  22. Iijima,D., Sugama,H., Takahashi,Y., Hirai,M., Togashi,Y., Xie,J., Shen,J., Ke,Y., Akatsuka,H., Kawaguchi,T., Takedomi,K., Kashima,A., Nishio,M., Inui,Y., Yoneda,H., Xia,G. and Iijima,T.
    Discovery of SPH3127: A Novel, Highly Potent, and Orally Active Direct Renin Inhibitor
    J Med Chem (2022) 65, 10882-10897. PubMed  Europe PubMed DOI  I
  23. Iijima,D., Sugama,H., Awai,N., Takahashi,Y., Togashi,Y., Takebe,T., Xie,J., Shen,J., Ke,Y., Akatsuka,H., Kawaguchi,T., Takedomi,K., Kashima,A., Nishio,M., Inui,Y., Yoneda,H., Xia,G. and Iijima,T.
    Discovery of Novel 2-Carbamoyl Morpholine Derivatives as Highly Potent and Orally Active Direct Renin Inhibitors
    ACS Med Chem Lett (2022) 13, 1351-1357. PubMed  Europe PubMed DOI  PMC  EPMC
  24. Piesanen,J., Valjakka,J., Niemela,S., Borgenstrom,M., Nikkari,S., Hytonen,V., Maatta,J. and Kunnas,T.
    Hepcidin is potential regulator for renin activity
    PLoS ONE (2022) 17, e0267343-e0267343. PubMed  Europe PubMed DOI  PMC  EPMC
  25. Senbonmatsu,T.
    Prorenin: What are its functions?
    Hypertens Res (2022) 45, 2021-2023. PubMed  Europe PubMed DOI
  26. Yokota,H., Hayashi,H., Hanaguri,J., Yamagami,S., Kushiyama,A., Nakagami,H. and Nagaoka,T.
    Effect of prorenin peptide vaccine on the early phase of diabetic retinopathy in a murine model of type 2 diabetes
    PLoS ONE (2022) 17, e0262568-e0262568. PubMed  Europe PubMed DOI  PMC  EPMC
    27. 2021
  27. Akther,J., Das,A., Rahman,M.A., Saha,S.K., Hosen,M.I., Ebihara,A., Nakagawa,T., Suzuki,F. and Nabi,A.H.M.N.
    Non-coding Single Nucleotide Variants of Renin and the (Pro)renin Receptor are Associated with Polygenic Diseases in a Bangladeshi Population
    Biochem Genet (2021) PubMed  Europe PubMed DOI  M
  28. Grahame,D.A.S., Dupuis,J.H., Bryksa,B.C., Tanaka,T. and Yada,R.Y.
    Improving the alkaline stability of pepsin through rational protein design using renin, an alkaline-stable aspartic protease, as a structural and functional reference
    Enzyme Microb Technol (2021) 150, 109871-109871. PubMed  Europe PubMed DOI
  29. Ma,S., Henderson,J.A. and Shen,J.
    Exploring the pH-Dependent Structure-Dynamics-Function Relationship of Human Renin
    J Chem Inf Model (2021) 61, 400-407. PubMed  Europe PubMed DOI
  30. Murray,J.B., Mikhael,C., Han,G., de Faria,L.P., Rody,W.J., Jr. and Holliday,L.S.
    Activation of (pro)renin by (pro)renin receptor in extracellular vesicles from osteoclasts
    Sci Rep (2021) 11, 9214-9214. PubMed  Europe PubMed DOI  PMC  EPMC
  31. Prieto,M.C., Gonzalez,A.A., Visniauskas,B. and Navar,L.G.
    The evolving complexity of the collecting duct renin-angiotensin system in hypertension
    Nat Rev Nephrol (2021) PubMed  Europe PubMed DOI
  32. Refaey,R.H., El-Ashrey,M.K. and Nissan,Y.M.
    Repurposing of renin inhibitors as SARS-COV-2 main protease inhibitors: A computational study
    Virology (2021) 554, 48-54. PubMed  Europe PubMed DOI  PMC  EPMC  I
    33. 2020
  33. Abdel Ghafar,M.T.
    An overview of the classical and tissue-derived renin-angiotensin-aldosterone system and its genetic polymorphisms in essential hypertension
    Steroids (2020) 163, 108701-108701. PubMed  Europe PubMed DOI
  34. Alhenc-Gelas,F.
    A new channel for the control of renin secretion in juxtaglomerular cells
    Kidney Int (2020) 98, 543-545. PubMed  Europe PubMed DOI
  35. Alsufyani,H.A. and Docherty,J.R.
    The renin angiotensin aldosterone system and COVID-19
    Saudi Pharm J (2020) 28, 977-984. PubMed  Europe PubMed DOI  PMC  EPMC  V
  36. Bartova,E., Legartova,S., Krejci,J. and Arcidiacono,O.A.
    Cell differentiation and aging accompanied by depletion of the ACE2 protein
    Aging (Albany NY) (2020) 12, 22495-22508. PubMed  Europe PubMed DOI
  37. Dilliott,A.A., Wang,J., Brown,E., Singh,G., Shkrum,M.J., Clin,M., Rupar,C.A., Hegele,R.A. and Siu,V.M.
    A novel homozygous variant in REN in a family presenting with classic features of disorders involving the renin-angiotensin pathway, without renal tubular dysgenesis
    Am J Med Genet A (2020) 182, 2284-2290. PubMed  Europe PubMed DOI
  38. Docherty,K.F., Campbell,R.T., Brooksbank,K.J.M., Godeseth,R.L., Forsyth,P., McConnachie,A., Roditi,G., Stanley,B., Welsh,P., Jhund,P.S., Petrie,M.C. and McMurray,J.J.V.
    Rationale and methods of a randomized trial evaluating the effect of neprilysin inhibition on left ventricular remodelling
    ESC Heart Fail (2020) PubMed  Europe PubMed DOI  I
  39. Feng,Y., Peng,K., Luo,R., Wang,F. and Yang,T.
    Site-1 Protease-Derived Soluble (Pro)Renin Receptor Contributes to Angiotensin II-Induced Hypertension in Mice
    Hypertension (2020) , HYPERTENSIONAHA12015100-HYPERTENSIONAHA12015100. PubMed  Europe PubMed DOI
  40. Grahame,D.S.A., Dupuis,J.H., Bryksa,B.C., Tanaka,T. and Yada,R.Y.
    Comparative bioinformatic and structural analyses of pepsin and renin
    Enzyme Microb Technol (2020) 141, 109632-109632. PubMed  Europe PubMed DOI
  41. Hartford,M., Herlitz,H., Perers,E., Karlsson,T., Herlitz,J., Persson,A. and Caidahl,K.
    Plasma renin activity has a complex prognostic role in patients with acute coronary syndromes
    Int J Cardiol (2020) PubMed  Europe PubMed DOI
  42. Kobayashi,Y., Haze,T., Yano,Y., Tamura,K., Kurihara,I., Ichijo,T., Yoneda,T., Katabami,T., Tsuiki,M., Wada,N., Ogawa,Y., Kawashima,J., Sone,M., Inagaki,N., Yamada,T., Okamoto,R., Fujita,M., Kamemura,K., Yamamoto,K., Izawa,S., Tanabe,A. and Naruse,M.
    Associations Between Changes in Plasma Renin Activity and Aldosterone Concentrations and Changes in Kidney Function After Treatment for Primary Aldosteronism
    Kidney Int Rep (2020) 5, 1291-1297. PubMed  Europe PubMed DOI  PMC  EPMC
  43. Kurbel,S.
    The renin-angiotensin system in COVID-19: Why ACE2 targeting by coronaviruses produces higher mortality in elderly hypertensive patients?
    Bioessays (2020) , e2000112-e2000112. PubMed  Europe PubMed DOI
  44. Liu,Y., Lin,Y., Zhang,M.M., Li,X.H., Liu,Y.Y., Zhao,J. and Shi,L.
    The relationship of plasma renin, angiotensin, and aldosterone levels to blood pressure variability and target organ damage in children with essential hypertension
    BMC Cardiovasc Disord (2020) 20, 296-296. PubMed  Europe PubMed DOI  PMC  EPMC  I
  45. Lou,L.L., Xie,L., Hu,Y., Chen,L.N., Liang,P., Shi,F., Liu,C.J. and Liu,H.M.
    [Association of age distribution with the expression of angiotensin-converting enzyme 2 in lung tissues in severe acute respiratory syndrome coronavirus 2 infection: reflections from the study of RAS pathway expression in mice]
    Zhongguo Dang Dai Er Ke Za Zhi (2020) 22, 1119-1124. PubMed  Europe PubMed  PMC  EPMC
  46. Ma,W.J., Lou,Y., Bian,J., Cai,J., Zhang,H.M. and Zhou,X.L.
    [Application of aldosterone/direct renin ratio before drug washout in the screening of primary aldosteronism]
    Zhonghua Yi Xue Za Zhi (2020) 100, 3250-3254. PubMed  Europe PubMed DOI
  47. Moin,A.S.M., Sathyapalan,T., Atkin,S.L. and Butler,A.E.
    Renin-Angiotensin System overactivation in polycystic ovary syndrome, a risk for SARS-CoV-2 infection?
    Metabol Open (2020) 7, 100052-100052. PubMed  Europe PubMed DOI  PMC  EPMC
  48. Salman,A.A., Salman,M.A., Shawkat,M., Hassan,S.A., Saad,E.H., Hussein,A.M., Refaie,O.R.M., Tourky,M.S., Shaaban,H.E., Abd Allah,N., El Domiaty,H.F. and Elkassar,H.
    Effect of Laparoscopic Sleeve Gastrectomy on Vasoactive Mediators in Obese Hypertensive Patients: A Prospective Study
    Clin Endocrinol (Oxf) (2020) PubMed  Europe PubMed DOI
  49. Siljee,S., Pilkington,T., Brasch,H.D., Bockett,N., Patel,J., Paterson,E., Davis,P.F. and Tan,S.T.
    Cancer Stem Cells in Head and Neck Metastatic Malignant Melanoma Express Components of the Renin-Angiotensin System
    Life (Basel) (2020) 10 PubMed  Europe PubMed DOI
  50. Urushihara,M., Kondo,S., Kinoshita,Y., Ozaki,N., Jamba,A., Nagai,T., Fujioka,K., Hattori,T. and Kagami,S.
    (Pro)renin receptor promotes crescent formation via the ERK1/2 and Wnt/beta-catenin pathways in glomerulonephritis
    Am J Physiol Renal Physiol (2020) 319, F571-F571. PubMed  Europe PubMed DOI
  51. Wanka,H., Lutze,P., Staar,D., Bracke,K., Golchert,J. and Peters,J.
    Angiotensin dependent and angiotensin independent protective effects of renin-b in H9c2 cells after anoxia
    Sci Rep (2020) 10, 19689-19689. PubMed  Europe PubMed DOI  PMC  EPMC
    52. 2019
  52. Yan,Y., Zhou,A., Carrell,R.W. and Read,R.J.
    Structural basis for the specificity of renin-mediated angiotensinogen cleavage
    J Biol Chem (2019) 294, 2353-2364. PubMed  Europe PubMed DOI  S
    53. 2018
  53. Nakano,D. and Nishiyama,A.
    A novel role of renin inhibitor in the complement cascade
    Kidney Int (2018) 94, 650-652. PubMed  Europe PubMed DOI  I
  54. Strecker,C. and Meyer,B.
    Plasticity of the binding site of renin: optimized selection of protein structures for ensemble docking
    J Chem Inf Model (2018) 58, 1121-1131. PubMed  Europe PubMed DOI  I
  55. Tavassoli,Z., Taghdir,M. and Ranjbar,B.
    Renin inhibition by soyasaponin I: a potent native anti-hypertensive compound
    J Biomol Struct Dyn (2018) 36, 166-176. PubMed  Europe PubMed DOI
  56. Tokuhara,H., Imaeda,Y., Fukase,Y., Iwanaga,K., Taya,N., Watanabe,K., Kanagawa,R., Matsuda,K., Kajimoto,Y., Kusumoto,K., Kondo,M., Snell,G., Behnke,C.A. and Kuroita,T.
    Discovery of benzimidazole derivatives as orally active renin inhibitors: optimization of 3,5-disubstituted piperidine to improve pharmacokinetic profile
    Bioorg Med Chem (2018) 26, 3261-3286. PubMed  Europe PubMed DOI  I
    57. 2017
  57. Cloudsdale,I.S., Dickson JK Jr, Barta,T.E., Grella,B.S., Smith,E.D., Kulp JL 3rd, Guarnieri,F. and Kulp JL Jr
    Design, synthesis and biological evaluation of renin inhibitors guided by simulated annealing of chemical potential simulations
    Bioorg Med Chem (2017) 25, 3947-3963. PubMed  Europe PubMed DOI  I
  58. Fu,Y., Alashi,A.M., Young,J.F., Therkildsen,M. and Aluko,R.E.
    Enzyme inhibition kinetics and molecular interactions of patatin peptides with angiotensin I-converting enzyme and renin
    Int J Biol Macromol (2017) 101, 207-213. PubMed  Europe PubMed DOI  I
  59. Lawhorn,B.G., Tran,T., Hong,V.S., Morgan,L.A., Le,B.T., Harpel,M.R., Jolivette,L., Diaz,E., Schwartz,B., Gross,J.W., Tomaszek,T., Semus,S., Concha,N., Smallwood,A., Holt,D.A. and Kallander,L.S.
    Discovery of renin inhibitors containing a simple aspartate binding moiety that imparts reduced P450 inhibition
    Bioorg Med Chem Lett (2017) 27, 4838-4843. PubMed  Europe PubMed DOI  I
  60. Marszalek,D., Goldnik,A., Winiecka,I., Jaworsk,P. and Mazurek Aleksander,P.
    New renin inhibitors - stability and activity determination. Part IV
    Acta Pol Pharm (2017) 74, 393-399. PubMed  Europe PubMed  I
  61. Shinohara,K., Nakagawa,P., Gomez,J., Morgan,D.A., Littlejohn,N.K., Folchert,M.D., Weidemann,B.J., Liu,X., Walsh,S.A., Ponto,L.L., Rahmouni,K., Grobe,J.L. and Sigmund,C.D.
    Selective deletion of renin-b in the brain alters drinking and metabolism
    Hypertension (2017) 70, 990-997. PubMed  Europe PubMed DOI  K
  62. Wilkinson,M.C., Nightingale,D.J.H., Harrison,R.A. and Wagstaff,S.C.
    Isolation and characterization of renin-like aspartic-proteases from Echis ocellatus venom
    Toxicon (2017) 137, 92-94. PubMed  Europe PubMed DOI  I
    63. 2016
  63. Imaeda,Y., Tawada,M., Suzuki,S., Tomimoto,M., Kondo,M., Tarui,N., Sanada,T., Kanagawa,R., Snell,G., Behnke,C.A., Kubo,K. and Kuroita,T.
    Structure-based design of a new series of N-(piperidin-3-yl)pyrimidine-5-carboxamides as renin inhibitors
    Bioorg Med Chem (2016) 24, 5771-5780. PubMed  Europe PubMed DOI  I
  64. Imaeda,Y., Tokuhara,H., Fukase,Y., Kanagawa,R., Kajimoto,Y., Kusumoto,K., Kondo,M., Snell,G., Behnke,C.A. and Kuroita,T.
    Discovery of TAK-272: a novel, potent, and orally active renin inhibitor
    ACS Med Chem Lett (2016) 7, 933-938. PubMed  Europe PubMed DOI  PMC  EPMC  I
  65. Ramanathan,G., Elumalai,R., Periyasamy,S. and Lakkakula,B.V.
    Renin gene rs1464816 polymorphism contributes to chronic kidney disease progression in ADPKD
    J Biomed Sci (2016) 23, 1-1. PubMed  Europe PubMed DOI  PMC  EPMC  M
  66. Shinohara,K., Liu,X., Morgan,D.A., Davis,D.R., Sequeira-Lopez,M.L., Cassell,M.D., Grobe,J.L., Rahmouni,K. and Sigmund,C.D.
    Selective deletion of the brain-specific isoform of renin causes neurogenic hypertension
    Hypertension (2016) 68, 1385-1392. PubMed  Europe PubMed DOI  K
  67. Tawada,M., Suzuki,S., Imaeda,Y., Oki,H., Snell,G., Behnke,C.A., Kondo,M., Tarui,N., Tanaka,T., Kuroita,T. and Tomimoto,M.
    Novel approach of fragment-based lead discovery applied to renin inhibitors
    Bioorg Med Chem (2016) 24, 6066-6074. PubMed  Europe PubMed DOI  I
  68. Winiecka,I., Jaworski,P., Mazurek,A.P., Marszalek,D., Goldnik,A. and Sokulski,D.
    Novel renin inhibitors containing derivatives of N-alkylleucyl-beta-hydroxy-gamma-amino acids
    J Pept Sci (2016) 22, 106-115. PubMed  Europe PubMed DOI  I
    69. 2015
  69. da Mota,E.G., Duarte,M.H., Da Cunha,E.F.F. and Freitas,M.P.
    Theoretical design of new indole-3-carboxamide derivatives as renin inhibitors
    Med Chem Res (2015) 24, 3097-3106. DOI  I
  70. Lorthiois,E., Cumin,F., Ehrhardt,C., Kosaka,T., Sellner,H., Ostermann,N., Francotte,E., Wagner,T. and Maibaum,J.
    trans-(3S,4S)-Disubstituted pyrrolidines as inhibitors of the human aspartyl protease renin. Part I: Prime site exploration using an amino linker
    Bioorg Med Chem Lett (2015) 25, 1782-1786. PubMed  Europe PubMed DOI  I
  71. McKittrick,B.A., Caldwell,J.P., Bara,T., Boykow,G., Chintala,M., Clader,J., Czarniecki,M., Courneya,B., Duffy,R., Fleming,L., Giessert,R., Greenlee,W.J., Heap,C., Hong,L., Huang,Y., Iserloh,U., Josien,H., Khan,T., Korfmacher,W., Liang,X., Mazzola,R., Mitra,S., Moore,K., Orth,P., Rajagopalan,M., Roy,S., Sakwa,S., Strickland,C., Vaccaro,H., Voigt,J., Wang,H., Wong,J., Zhang,R. and Zych,A.
    Iminopyrimidinones: a novel pharmacophore for the development of orally active renin inhibitors
    Bioorg Med Chem Lett (2015) 25, 1592-1596. PubMed  Europe PubMed DOI  I
  72. Park,J., Song,K., Jang,Y. and Kim Yoon,S.
    A polymorphism of the renin gene rs6682082 is associated with essential hypertension risk and blood pressure levels in Korean women
    Yonsei Med J (2015) 56, 227-234. PubMed  Europe PubMed DOI  M
  73. Raff,H., Gehrand,A., Bruder,E.D., Hoffman,M.J., Engeland,W.C. and Moreno,C.
    Renin knockout rat: control of adrenal aldosterone and corticosterone synthesis in vitro and adrenal gene expression
    Am J Physiol Regul Integr Comp Physiol (2015) , R73-R77. PubMed  Europe PubMed DOI  K
  74. Sellner,H., Cottens,S., Cumin,F., Ehrhardt,C., Kosaka,T., Lorthiois,E., Ostermann,N., Webb,R.L., Rigel,D.F., Wagner,T. and Maibaum,J.
    trans-3,4-Disubstituted pyrrolidines as inhibitors of the human aspartyl protease renin. Part II: Prime site exploration using an oxygen linker
    Bioorg Med Chem Lett (2015) 25, 1787-1791. PubMed  Europe PubMed DOI  I
  75. Sequeira-Lopez,M.L., Nagalakshmi,V.K., Li,M., Sigmund,C.D. and Gomez,R.A.
    Vascular versus tubular renin: role in kidney development
    Am J Physiol Regul Integr Comp Physiol (2015) 309, R650-R657. PubMed  Europe PubMed DOI  K
  76. Sharma,M.C.
    Structural insights into mode of actions of novel substituted 4- and 6-azaindole-3-carboxamides analogs as renin inhibitors: molecular modeling studies
    Med Chem Res (2015) 24, 1038-1059. DOI  I
  77. Sun,X., Wen,X., Chen,Y.Y., Shi,C., Gao,C., Wu,Y., Wang,L.J., Yang,X.H. and Sun,H.
    Discovery of highly potent renin inhibitors potentially interacting with the S3' subsite of renin
    Eur J Med Chem (2015) 103, 269-288. PubMed  Europe PubMed DOI  I
  78. Tzoupis,H., Leonis,G., Avramopoulos,A., Reis,H., Czyznikowska,Z., Zerva,S., Vergadou,N., Peristeras,L.D., Papavasileiou,K.D., Alexis,M.N., Mavromoustakos,T. and Papadopoulos,M.G.
    Elucidation of the binding mechanism of renin using a wide array of computational techniques and biological assays
    J Mol Graph Model (2015) 62, 138-149. PubMed  Europe PubMed DOI
  79. Zhou,Z., Cheng,C. and Li,Y.
    Structure-based design and optimization of antihypertensive peptides to obtain high inhibitory potency against both renin and angiotensin I-converting enzyme
    SAR QSAR Environ Res (2015) 26, 1001-1016. PubMed  Europe PubMed DOI  I
    80. 2014
  80. Bras,N.F., Fernandes,P.A. and Ramos,M.J.
    Molecular dynamics studies on both bound and unbound renin protease
    J Biomol Struct Dyn (2014) 32, 351-363. PubMed  Europe PubMed DOI
  81. Calixto,A.R., Bras,N.F., Fernandes,P.A. and Ramos,M.J.
    Reaction mechanism of human renin studied by quantum mechanics/molecular mechanics (QM/MM) calculations
    ACS Catal (2014) 4, 3869-3876. DOI
  82. Ehara,T., Irie,O., Kosaka,T., Kanazawa,T., Breitenstein,W., Grosche,P., Ostermann,N., Suzuki,M., Kawakami,S., Konishi,K., Hitomi,Y., Toyao,A., Gunji,H., Cumin,F., Schiering,N., Wagner,T., Rigel,D.F., Webb,R.L., Maibaum,J. and Yokokawa,F.
    Structure-based design of substituted piperidines as a new class of highly efficacious oral direct renin inhibitors
    ACS Med Chem Lett (2014) 5, 787-792. PubMed  Europe PubMed DOI  PMC  EPMC  I
  83. Konoshita,T., Nakaya,T., Sakai,A., Yamada,M., Ichikawa,M., Sato,S., Imagawa,M., Fujii,M., Yamamoto,K., Makino,Y., Arakawa,K., Suzuki,J. and Ishizuka,T.
    Determinants of plasma renin activity: role of a human renin gene variant as a genetic factor
    Medicine (Baltimore) (2014) 93, e354-e354. PubMed  Europe PubMed DOI  M
  84. Lu,X., Krop,M., Batenburg,W.W., Musterd-Bhaggoe,U.M., Garrelds,I.M. and Danser,A.H.
    Renin inhibitor VTP-27999 differs from aliskiren: focus on their intracellular accumulation and the (pro)renin receptor
    J Hypertens (2014) 32, 1255-1263. PubMed  Europe PubMed DOI  I
  85. Marszalek,D., Goldnik,A., Mazurek,A.P., Winiecka,I., Jaworski,P., Szerszan,S., Kozikowska,E. and Pawlik,T.
    New renin inhibitors - stability and activity determination. Part II
    Acta Pol Pharm (2014) 71, 555-561. PubMed  Europe PubMed  I
  86. Marszalek,D., Goldnik,A., Mazurek,A.P., Winiecka,I. and Jaworskpi,P.
    New renin inhibitors - stability and activity determination. Part I
    Acta Pol Pharm (2014) 71, 545-553. PubMed  Europe PubMed  I
  87. Mori,Y., Iwamoto,M., Mori,K., Yoshida,M., Honda,T., Nagayama,T. and Nishi,T.
    An efficient synthesis of (3S,5S)-5-[3,3-dimethyl-1-(o-tolyl)-6-OXO-2H- pyridin-4-YL]- piperidine-3-carboxamide as potent renin inhibitor
    Heterocycles (2014) 89, 1413-1426. DOI  I
  88. Shieh,W.-C., Du,Z., Kim,H., Liu,Y. and Prashad,M.
    Development of a total telescoped synthesis of a renin inhibitor containing 3,4,5-substituted piperidine with sterically hindered amide bonds
    Org Process Res Dev (2014) 18, 1339-1344. DOI  I
  89. Weber,M.A.
    John Laragh and the renin thesis: creating a paradigm
    Am J Hypertens (2014) 27, 1008-1009. PubMed  Europe PubMed DOI  V
  90. Winiecka,I., Marszalek,D., Goldnik,A., Jaworski,P. and Mazurek,A.P.
    New renin inhibitors containing phenylalanylhistidyl-gamma-amino acid derivatives in P3 - P1' position
    Acta Pol Pharm (2014) 71, 59-69. PubMed  Europe PubMed  I
  91. Winiecka,I., Marszalek,D., Goldnik,A., Jaworski,P. and Mazurek,A.P.
    Novel renin inhibitors containing a non-peptide aminoalkanoyl moiety at P1-P1' position
    Pharmazie (2014) 69, 263-270. PubMed  Europe PubMed DOI  I
  92. Xa,L.K., Lacombe,M.J., Mercure,C., Lazure,C. and Reudelhuber,T.L.
    General lysosomal hydrolysis can process prorenin accurately
    Am J Physiol Regul Integr Comp Physiol (2014) 307, R505-R513. PubMed  Europe PubMed DOI
  93. Xiang,Y., Song,J. and Zhang,Z.
    Topomer CoMFA and virtual screening studies of azaindole class renin inhibitors
    Comb Chem High Throughput Screen (2014) 17, 458-472. PubMed  Europe PubMed DOI  I
    94. 2013
  94. Harmsen,R.A.G., Sivertsen,A., Michetti,D., Brandsdal,B.O., Sydnes,L.K. and Haug,B.E.
    Synthesis and docking of novel piperidine renin inhibitors
    Monatsh Chem (2013) 144, 479-494. DOI  I
  95. Krop,M., Lu,X., Verdonk,K., Schalekamp,M.A., van Gool,J.M., McKeever,B.M., Gregg,R. and Danser,A.H.
    New renin inhibitor VTP-27999 alters renin immunoreactivity and does not unfold prorenin
    Hypertension (2013) 61, 1075-1082. PubMed  Europe PubMed DOI  I
  96. Lorthiois,E., Breitenstein,W., Cumin,F., Ehrhardt,C., Francotte,E., Jacoby,E., Ostermann,N., Sellner,H., Kosaka,T., Webb,R.L., Rigel,D.F., Hassiepen,U., Richert,P., Wagner,T. and Maibaum,J.
    The discovery of novel potent trans-3,4-disubstituted pyrrolidine inhibitors of the human aspartic protease renin from in silico three-dimensional (3D) pharmacophore searches
    J Med Chem (2013) 56, 2207-2217. PubMed  Europe PubMed DOI  I
  97. Michida,M., Takayanagi,Y., Imai,M., Furuya,Y., Kimura,K., Kitawaki,T., Tomori,H. and Kajino,H.
    Convergent asymmetric synthesis of a renin inhibitor: a highly efficient construction method of three stereogenic centers
    Org Process Res Dev (2013) 17, 1430-1439. DOI  I
  98. Mori,Y., Ogawa,Y., Mochizuki,A., Nakamura,Y., Fujimoto,T., Sugita,C., Miyazaki,S., Tamaki,K., Nagayama,T., Nagai,Y., Inoue,S., Chiba,K. and Nishi,T.
    Synthesis and optimization of novel (3S,5R)-5-(2,2-dimethyl-5-oxo-4-phenylpiperazin-1-yl)piperidine-3-carboxamides as orally active renin inhibitors
    Bioorg Med Chem (2013) 21, 5907-5922. PubMed  Europe PubMed DOI  I
  99. Nakamura,Y., Fujimoto,T., Ogawa,Y., Namiki,H., Suzuki,S., Asano,M., Sugita,C., Mochizuki,A., Miyazaki,S., Tamaki,K., Nagai,Y., Inoue,S., Nagayama,T., Kato,M., Chiba,K., Takasuna,K. and Nishi,T.
    Lead optimization of 5-amino-6-(2,2-dimethyl-5-oxo-4-phenylpiperazin-1-yl)-4-hydroxyhexanamides to reduce a cardiac safety issue: Discovery of DS-8108b, an orally active renin inhibitor
    Bioorg Med Chem (2013) 21, 3175-3196. PubMed  Europe PubMed DOI  I
  100. Ostermann,N., Ruedisser,S., Ehrhardt,C., Breitenstein,W., Marzinzik,A., Jacoby,E., Vangrevelinghe,E., Ottl,J., Klumpp,M., Hartwieg,J.C., Cumin,F., Hassiepen,U., Trappe,J., Sedrani,R., Geisse,S., Gerhartz,B., Richert,P., Francotte,E., Wagner,T., Kromer,M., Kosaka,T., Webb,R.L., Rigel,D.F., Maibaum,J. and Baeschlin,D.K.
    A novel class of oral direct renin inhibitors: highly potent 3,5-disubstituted piperidines bearing a tricyclic P3-P1 pharmacophore
    J Med Chem (2013) 56, 2196-2206. PubMed  Europe PubMed DOI  I
  101. Subramanian,G.
    Computational modeling and design of renin inhibitors
    Bioorg Med Chem Lett (2013) 23, 460-465. PubMed  Europe PubMed DOI  I
  102. Subramanian,G. and Rao,S.N.
    Comprehending renin inhibitor's binding affinity using structure-based approaches
    Bioorg Med Chem Lett (2013) 23, 6667-6672. PubMed  Europe PubMed DOI  I
    103. 2012
  103. Bras,N.F., Ramos,M.J. and Fernandes,P.A.
    The catalytic mechanism of mouse renin studied with QM/MM calculations
    Phys Chem Chem Phys (2012) 14, 12605-12613. PubMed  Europe PubMed DOI
  104. Fournier,P.A., Arbour,M., Cauchon,E., Chen,A., Chefson,A., Ducharme,Y., Falgueyret,J.P., Gagne,S., Grimm,E., Han,Y., Houle,R., Lacombe,P., Levesque,J.F., MacDonald,D., Mackay,B., McKay,D., Percival,M.D., Ramtohul,Y., St-Jacques,R. and Toulmond,S.
    Design and synthesis of potent, isoxazole-containing renin inhibitors
    Bioorg Med Chem Lett (2012) 22, 2670-2674. PubMed  Europe PubMed DOI  I
  105. Ishchenko,A., Liu,Z., Lindblom,P., Wu,G., Jim,K.C., Gregg,R.D., Claremon,D.A. and Singh,S.B.
    Structure-based design technology contour and its application to the design of renin inhibitors
    J Chem Inf Model (2012) 52, 2089-2097. PubMed  Europe PubMed DOI  I
  106. Iwai,M., Senba,I., Kanno,H., Nakaoka,H., Inaba,S. and Horiuchi,M.
    Renin inhibitors inhibited the activity of recombinant human renin but not activity in healthy human plasma
    Clin Lab (2012) 58, 291-298. PubMed  Europe PubMed
  107. Jing,T., Feng,J., Zuo,Y., Ran,B., Liu,J. and He,G.
    Exploring the substructural space of indole-3-carboxamide derivatives binding to renin: a novel active-site spatial partitioning approach
    J Mol Model (2012) 18, 4417-4426. PubMed  Europe PubMed DOI  I
  108. Kunikullaya,U., Ananthakrishnan,V. and Goturu,J.
    Robert Tigerstedt and the discovery of renin - a revisit
    Int J Cardiol (2012) 158, 1-5. PubMed  Europe PubMed DOI
  109. Lacombe,P., Arbour,M., Aspiotis,R., Cauchon,E., Chen,A., Dube,D., Falgueyret,J.P., Fournier,P.A., Gallant,M., Grimm,E., Han,Y., Juteau,H., Liu,S., Mellon,C., Ramtohul,Y., Simard,D., St-Jacques,R. and Tsui,G.C.
    3,4-Diarylpiperidines as potent renin inhibitors
    Bioorg Med Chem Lett (2012) 22, 1953-1957. PubMed  Europe PubMed DOI  I
  110. Long,Y., Zhang,L.F., Zhang,Y. and Zhang,C.Y.
    Single quantum dot based nanosensor for renin assay
    Anal Chem (2012) 84, 8846-8852. PubMed  Europe PubMed DOI  A
  111. Morales,R., Watier,Y. and Bocskei,Z.
    Human prorenin structure sheds light on a novel mechanism of its autoinhibition and on its non-proteolytic activation by the (pro)renin receptor
    J Mol Biol (2012) 421, 100-111. PubMed  Europe PubMed DOI  S
  112. Mori,Y., Ogawa,Y., Mochizuki,A., Nakamura,Y., Sugita,C., Miyazaki,S., Tamaki,K., Matsui,Y., Takahashi,M., Nagayama,T., Nagai,Y., Inoue,S. and Nishi,T.
    Design and discovery of new (3S,5R)-5-[4-(2-chlorophenyl)-2,2-dimethyl-5-oxopiperazin-1-yl]piperidine-3-carboxamides as potent renin inhibitors
    Bioorg Med Chem Lett (2012) 22, 7677-7682. PubMed  Europe PubMed DOI  I
  113. Nakamura,Y., Fujimoto,T., Ogawa,Y., Sugita,C., Miyazaki,S., Tamaki,K., Takahashi,M., Matsui,Y., Nagayama,T., Manabe,K., Mizuno,M., Masubuchi,N., Chiba,K. and Nishi,T.
    Discovery of DS-8108b, a novel orally bioavailable renin inhibitor
    ACS Med Chem Lett (2012) 3, 754-758. PubMed  Europe PubMed DOI  I
  114. Nakamura,Y., Sugita,C., Meguro,M., Miyazaki,S., Tamaki,K., Takahashi,M., Nagai,Y., Nagayama,T., Kato,M., Suemune,H. and Nishi,T.
    Design and optimization of novel (2S,4S,5S)-5-amino-6-(2,2-dimethyl-5-oxo-4-phenylpiperazin-1-yl)-4-hydroxy-2-isopropylhexanamides as renin inhibitors
    Bioorg Med Chem Lett (2012) 22, 4561-4566. PubMed  Europe PubMed DOI  I
  115. Nurun Nabi,A.H.M., Suzuki,F. and Inagami,T.
    Renin
    [ISSN:978-0-12-407744-7] (2012) 3, 71-82. DOI
  116. Udenigwe,C.C., Li,H. and Aluko,R.E.
    Quantitative structure-activity relationship modeling of renin-inhibiting dipeptides
    Amino Acids (2012) 42, 1379-1386. PubMed  Europe PubMed DOI  I
  117. Zhang,J., Preda,D.V., Vasquez,K.O., Morin,J., Delaney,J., Bao,B., Percival,M.D., Xu,D., McKay,D., Klimas,M., Bednar,B., Sur,C., Gao,D.Z., Madden,K., Yared,W., Rajopadhye,M. and Peterson,J.D.
    A fluorogenic near-infrared imaging agent for quantifying plasma and local tissue renin activity in vivo and ex vivo
    Am J Physiol Renal Physiol (2012) 303, F593-F603. PubMed  Europe PubMed DOI  L
    118. 2011
  118. Al-Nadaf,A.H. and Taha,M.O.
    Discovery of new renin inhibitory leads via sequential pharmacophore modeling, QSAR analysis, in silico screening and in vitro evaluation
    J Mol Graph Model (2011) 29, 843-864. PubMed  Europe PubMed DOI  I
  119. Aspiotis,R., Chen,A., Cauchon,E., Dube,D., Falgueyret,J.P., Gagne,S., Gallant,M., Grimm,E.L., Houle,R., Juteau,H., Lacombe,P., Laliberte,S., Levesque,J.F., MacDonald,D., McKay,D., Percival,M.D., Roy,P., Soisson,S.M. and Wu,T.
    The discovery and synthesis of potent zwitterionic inhibitors of renin
    Bioorg Med Chem Lett (2011) 21, 2430-2436. PubMed  Europe PubMed DOI  I
  120. Beck,B.B., Trachtman,H., Gitman,M., Miller,I., Sayer,J.A., Pannes,A., Baasner,A., Hildebrandt,F. and Wolf,M.T.
    Autosomal dominant mutation in the signal peptide of renin in a kindred with anemia, hyperuricemia, and CKD
    Am J Kidney Dis (2011) 58, 821-825. PubMed  Europe PubMed DOI  M
  121. Brakch,N., Allemandou,F., Keller,I. and Nussberger,J.
    The renin prosequence enhances constitutive secretion of renin and optimizes renin activity
    Curr Neurovasc Res (2011) 8, 121-130. PubMed  Europe PubMed DOI
  122. Chen,A., Campeau,L.C., Cauchon,E., Chefson,A., Ducharme,Y., Dube,D., Falgueyret,J.P., Fournier,P.A., Gagne,S., Grimm,E., Han,Y., Houle,R., Huang,J.Q., Lacombe,P., Laliberte,S., Levesque,J.F., Liu,S., MacDonald,D., Mackay,B., McKay,D., Percival,M.D., Regan,C., Regan,H., St-Jacques,R. and Toulmond,S.
    Renin inhibitors for the treatment of hypertension: design and optimization of a novel series of pyridone-substituted piperidines
    Bioorg Med Chem Lett (2011) 21, 3970-3975. PubMed  Europe PubMed DOI  I
  123. Chen,A., Cauchon,E., Chefson,A., Dolman,S., Ducharme,Y., Dube,D., Falgueyret,J.P., Fournier,P.A., Gagne,S., Gallant,M., Grimm,E., Han,Y., Houle,R., Huang,J.Q., Hughes,G., Juteau,H., Lacombe,P., Lauzon,S., Levesque,J.F., Liu,S., MacDonald,D., Mackay,B., McKay,D., Percival,M.D., St-Jacques,R. and Toulmond,S.
    Renin inhibitors for the treatment of hypertension: design and optimization of a novel series of tertiary alcohol-bearing piperidines
    Bioorg Med Chem Lett (2011) 21, 3976-3981. PubMed  Europe PubMed DOI  I
  124. Chen,A., Aspiotis,R., Campeau,L.C., Cauchon,E., Chefson,A., Ducharme,Y., Falgueyret,J.P., Gagne,S., Han,Y., Houle,R., Laliberte,S., Larouche,G., Levesque,J.F., McKay,D. and Percival,D.
    Renin inhibitors for the treatment of hypertension: design and optimization of a novel series of spirocyclic piperidines
    Bioorg Med Chem Lett (2011) 21, 7399-7404. PubMed  Europe PubMed DOI  I
  125. Fisher,N.D. and Meagher,E.A.
    Renin inhibitors
    J Clin Hypertens (Greenwich) (2011) 13, 662-666. PubMed  Europe PubMed DOI  I
  126. Ghasemi,J.B. and Pirhadi,S.
    Docking alignment-3D-qsar of a new class of potent and non-chiral indole-3-carboxamide-based renin inhibitors
    Collect Czech Chem Commun (2011) 76, 1447-1469. DOI  I
  127. Jia,L., Simpson,R.D., Yuan,J., Xu,Z., Zhao,W., Cacatian,S., Tice,C.M., Guo,J., Ishchenko,A., Singh,S.B., Wu,Z., McKeever,B.M., Bukhtiyarov,Y., Johnson,J.A., Doe,C.P., Harrison,R.K., McGeehan,G.M., Dillard,L.W., Baldwin,J.J. and Claremon,D.A.
    Discovery of VTP-27999, an alkyl amine renin inhibitor with potential for clinical utility
    ACS Med Chem Lett (2011) 2, 747-751. PubMed  Europe PubMed DOI  I
  128. Levesque,J.F., Bleasby,K., Chefson,A., Chen,A., Dube,D., Ducharme,Y., Fournier,P.A., Gagne,S., Gallant,M., Grimm,E., Hafey,M., Han,Y., Houle,R., Lacombe,P., Laliberte,S., MacDonald,D., Mackay,B., Papp,R. and Tschirret-Guth,R.
    Impact of passive permeability and gut efflux transport on the oral bioavailability of novel series of piperidine-based renin inhibitors in rodents
    Bioorg Med Chem Lett (2011) 21, 5547-5551. PubMed  Europe PubMed DOI  I
  129. Matter,H., Scheiper,B., Steinhagen,H., Bocskei,Z., Fleury,V. and McCort,G.
    Structure-based design and optimization of potent renin inhibitors on 5- or 7-azaindole-scaffolds
    Bioorg Med Chem Lett (2011) 21, 5487-5492. PubMed  Europe PubMed DOI  I
  130. Scheiper,B., Matter,H., Steinhagen,H., Bocskei,Z., Fleury,V. and McCort,G.
    Structure-based optimization of potent 4- and 6-azaindole-3-carboxamides as renin inhibitors
    Bioorg Med Chem Lett (2011) 21, 5480-5486. PubMed  Europe PubMed DOI  I
  131. Sun,B., Williams,J.S., Pojoga,L., Chamarthi,B., Lasky-Su,J., Raby,B.A., Hopkins,P.N., Jeunemaitre,X., Brown,N.J., Ferri,C. and Williams,G.H.
    Renin gene polymorphism: its relationship to hypertension, renin levels and vascular responses
    J Renin Angiotensin Aldosterone Syst (2011) 12, 564-571. PubMed  Europe PubMed DOI  M
  132. Sund,C., Belda,O., Wiktelius,D., Sahlberg,C., Vrang,L., Sedig,S., Hamelink,E., Henderson,I., Agback,T., Jansson,K., Borkakoti,N., Derbyshire,D., Eneroth,A. and Samuelsson,B.
    Design and synthesis of potent macrocyclic renin inhibitors
    Bioorg Med Chem Lett (2011) 21, 358-362. PubMed  Europe PubMed DOI  I
  133. Thangapandian,S., John,S., Sakkiah,S. and Lee,K.W.
    Potential virtual lead identification in the discovery of renin inhibitors: application of ligand and structure-based pharmacophore modeling approaches
    Eur J Med Chem (2011) 46, 2469-2476. PubMed  Europe PubMed DOI  I
  134. Wu,Y., Shi,C., Sun,X., Wu,X. and Sun,H.
    Synthesis, biological evaluation and docking studies of octane-carboxamide based renin inhibitors with extended segments toward S3' site of renin
    Bioorg Med Chem (2011) 19, 4238-4249. PubMed  Europe PubMed DOI  I
  135. Yuan,J., Simpson,R.D., Zhao,W., Tice,C.M., Xu,Z., Cacatian,S., Jia,L., Flaherty,P.T., Guo,J., Ishchenko,A., Wu,Z., McKeever,B.M., Scott,B.B., Bukhtiyarov,Y., Berbaum,J., Panemangalore,R., Bentley,R., Doe,C.P., Harrison,R.K., McGeehan,G.M., Singh,S.B., Dillard,L.W., Baldwin,J.J. and Claremon,D.A.
    Biphenyl/diphenyl ether renin inhibitors: filling the S1 pocket of renin via the S3 pocket
    Bioorg Med Chem Lett (2011) 21, 4836-4843. PubMed  Europe PubMed DOI  I
    136. 2010
  136. Azizi,M. and Menard,J.
    Review: measurement of plasma renin: a critical review of methodology
    J Renin Angiotensin Aldosterone Syst (2010) 11, 89-90. PubMed  Europe PubMed DOI  A  V
  137. Bleyer,A.J., Zivna,M., Hulkova,H., Hodanova,K., Vyletal,P., Sikora,J., Zivny,J., Sovova,J., Hart,T.C., Adams,J.N., Elleder,M., Kapp,K., Haws,R., Cornell,L.D., Kmoch,S. and Hart,P.S.
    Clinical and molecular characterization of a family with a dominant renin gene mutation and response to treatment with fludrocortisone
    Clin Nephrol (2010) 74, 411-422. PubMed  Europe PubMed  M
  138. Castrop,H., Hocherl,K., Kurtz,A., Schweda,F., Todorov,V. and Wagner,C.
    Physiology of kidney renin
    Physiol Rev (2010) 90, 607-673. PubMed  Europe PubMed DOI  V
  139. Chen,A., Bayly,C., Bezencon,O., Richard-Bildstein,S., Dube,D., Dube,L., Gagne,S., Gallant,M., Gaudreault,M., Grimm,E., Houle,R., Lacombe,P., Laliberte,S., Levesque,J.F., Liu,S., MacDonald,D., Mackay,B., Martin,D., McKay,D., Powell,D., Remen,L., Soisson,S. and Toulmond,S.
    Design and optimization of a substituted amino propanamide series of renin inhibitors for the treatment of hypertension
    Bioorg Med Chem Lett (2010) 20, 2204-2209. PubMed  Europe PubMed DOI  I
  140. Chen,A., Dube,D., Dube,L., Gagne,S., Gallant,M., Gaudreault,M., Grimm,E., Houle,R., Lacombe,P., Laliberte,S., Liu,S., MacDonald,D., Mackay,B., Martin,D., McKay,D., Powell,D. and Levesque,J.F.
    Addressing time-dependent CYP 3A4 inhibition observed in a novel series of substituted amino propanamide renin inhibitors, a case study
    Bioorg Med Chem Lett (2010) 20, 5074-5079. PubMed  Europe PubMed DOI  I
  141. Corminboeuf,O., Bezencon,O., Remen,L., Grisostomi,C., Richard-Bildstein,S., Bur,D., Prade,L., Strickner,P., Hess,P., Fischli,W., Steiner,B. and Treiber,A.
    Piperidine-based renin inhibitors: upper chain optimization
    Bioorg Med Chem Lett (2010) 20, 6291-6296. PubMed  Europe PubMed DOI  I
  142. Corminboeuf,O., Bezencon,O., Grisostomi,C., Remen,L., Richard-Bildstein,S., Bur,D., Prade,L., Hess,P., Strickner,P., Fischli,W., Steiner,B. and Treiber,A.
    Design and optimization of new piperidines as renin inhibitors
    Bioorg Med Chem Lett (2010) 20, 6286-6290. PubMed  Europe PubMed DOI  I
  143. Gotoh,T., Kikuchi,K.I. and Takahashi,S.
    Active human renin production using a baculovirus expression vector system: an effective method for preventing excessive proteolytic degradation of recombinant proteins
    J Chem Eng Jpn (2010) 43, 603-607. DOI  E
  144. Gross,K.W., Gomez,R.A. and Sigmund,C.D.
    Twists and turns in the search for the elusive renin processing enzyme: focus on "Cathepsin B is not the processing enzyme for mouse prorenin"
    Am J Physiol Regul Integr Comp Physiol (2010) 298, R1209-R1211. PubMed  Europe PubMed DOI
  145. Israili,Z.H., Velasco,M. and Bermudez,V.
    Direct renin inhibitors as antihypertensive agents
    Am J Ther (2010) 17, 237-254. PubMed  Europe PubMed DOI  V  I
  146. Lacombe,P., Aspiotis,R., Bayly,C., Chen,A., Dube,D., Fortin,R., Gallant,M., Juteau,H., Liu,S., McKay,D., Roy,P. and Wu,T.
    Identification of a new biaryl scaffold generating potent renin inhibitors
    Bioorg Med Chem Lett (2010) 20, 5822-5826. PubMed  Europe PubMed DOI  I
  147. Mercure,C., Lacombe,M.J., Khazaie,K. and Reudelhuber,T.L.
    Cathepsin B is not the processing enzyme for mouse prorenin
    Am J Physiol Regul Integr Comp Physiol (2010) 298, R1212-R1216. PubMed  Europe PubMed DOI  K
  148. Scheiper,B., Matter,H., Steinhagen,H., Stilz,U., Bocskei,Z., Fleury,V. and McCort,G.
    Discovery and optimization of a new class of potent and non-chiral indole-3-carboxamide-based renin inhibitors
    Bioorg Med Chem Lett (2010) 20, 6268-6272. PubMed  Europe PubMed DOI  I
  149. Takahashi,S., Tokiwano,T., Hata,K., Kodama,I., Hokari,M., Suzuki,N., Yoshizawa,Y. and Gotoh,T.
    The occurrence of renin inhibitor in rice: isolation, identification, and structure-function relationship
    Biosci Biotechnol Biochem (2010) 74, 1713-1715. PubMed  Europe PubMed DOI  I
  150. Webb,R.L., Schiering,N., Sedrani,R. and Maibaum,J.
    Direct renin inhibitors as a new therapy for hypertension
    J Med Chem (2010) 53, 7490-7520. PubMed  Europe PubMed DOI  V  I
  151. Winiecka,I., Dudkiewicz-Wilczynska,J., Roman,I. and Paruszewski,R.
    New potential renin inhibitors with dipeptide replacements in the molecule
    Acta Pol Pharm (2010) 67, 367-374. PubMed  Europe PubMed  I
    152. 2009
  152. Bezencon,O., Bur,D., Weller,T., Richard-Bildstein,S., Remen,L., Sifferlen,T., Corminboeuf,O., Grisostomi,C., Boss,C., Prade,L., Delahaye,S., Treiber,A., Strickner,P., Binkert,C., Hess,P., Steiner,B. and Fischli,W.
    Design and preparation of potent, nonpeptidic, bioavailable renin inhibitors
    J Med Chem (2009) 52, 3689-3702. PubMed  Europe PubMed DOI  I
  153. Kher,V.
    Renin inhibition - benefit beyond hypertension control
    J Assoc Physicians India (2009) 57, 518-520. PubMed  Europe PubMed  I
  154. Nabi,A.H., Biswas,K.B., Nakagawa,T., Ichihara,A., Inagami,T. and Suzuki,F.
    Prorenin has high affinity multiple binding sites for (pro)renin receptor
    Biochim Biophys Acta Proteins Proteom (2009) 1794, 1838-1847. PubMed  Europe PubMed DOI
  155. Pinto,R. and Gradman,A.H.
    Direct renin inhibition: an update
    Curr Hypertens Rep (2009) 11, 456-462. PubMed  Europe PubMed DOI  V  I
  156. Remen,L., Bezencon,O., Richard-Bildstein,S., Bur,D., Prade,L., Corminboeuf,O., Boss,C., Grisostomi,C., Sifferlen,T., Strickner,P., Hess,P., Delahaye,S., Treiber,A., Weller,T., Binkert,C., Steiner,B. and Fischli,W.
    New classes of potent and bioavailable human renin inhibitors
    Bioorg Med Chem Lett (2009) 19, 6762-6765. PubMed  Europe PubMed DOI  I
  157. Riccioni,G., Vitulano,N., D'Orazio,N. and Bellocci,F.
    Aliskiren, the first approved renin inhibitor: clinical application and safety in the treatment of hypertension
    Adv Ther (2009) 26, 700-710. PubMed  Europe PubMed DOI  I
  158. Sanoski,C.A.
    Aliskiren: an oral direct renin inhibitor for the treatment of hypertension
    Pharmacotherapy (2009) 29, 193-212. PubMed  Europe PubMed DOI  I
  159. Tice,C.M., Xu,Z., Yuan,J., Simpson,R.D., Cacatian,S.T., Flaherty,P.T., Zhao,W., Guo,J., Ishchenko,A., Singh,S.B., Wu,Z., Scott,B.B., Bukhtiyarov,Y., Berbaum,J., Mason,J., Panemangalore,R., Cappiello,M.G., Muller,D., Harrison,R.K., McGeehan,G.M., Dillard,L.W., Baldwin,J.J. and Claremon,D.A.
    Design and optimization of renin inhibitors: orally bioavailable alkyl amines
    Bioorg Med Chem Lett (2009) 19, 3541-3545. PubMed  Europe PubMed DOI  I
  160. Yamaguchi,Y., Menear,K., Cohen,N.C., Mah,R., Cumin,F., Schnell,C., Wood,J.M. and Maibaum,J.
    The P1 N-isopropyl motif bearing hydroxyethylene dipeptide isostere analogues of aliskiren are in vitro potent inhibitors of the human aspartyl protease renin
    Bioorg Med Chem Lett (2009) 19, 4863-4867. PubMed  Europe PubMed DOI  I
    161. 2008
  161. Dockery,B.K. and Bisognano,J.D.
    Direct renin inhibition: an analysis of possible benefits
    Curr Hypertens Rep (2008) 10, 313-318. PubMed  Europe PubMed DOI  T  I
  162. Iwata,H., Nakagawa,T., Yoshioka,Y., Kagei,K., Imada,K., Nakane,C., Fujita,H., Suzuki,F. and Nakamura,Y.
    The coexistence of Ser84 in renin and His13 in angiotensinogen brings a pH profile of two separate peaks to the reaction of human renin and sheep angiotensinogen
    Biosci Biotechnol Biochem (2008) 72, 179-185. PubMed  Europe PubMed DOI
  163. Jensen,C., Herold,P. and Brunner,H.R.
    Aliskiren: the first renin inhibitor for clinical treatment
    Nat Rev Drug Discov (2008) 7, 399-410. PubMed  Europe PubMed DOI  I
  164. Major,T.C., Olszewski,B., Rosebury,W., Okerberg,C., Carlson,T., Ostroski,R., Schroeder,R., Kowala,M.C. and Leadley,R.
    A nonpeptide, piperidine renin inhibitor provides renal and cardiac protection in double-transgenic mice expressing human renin and angiotensinogen genes
    Cardiovasc Drugs Ther (2008) 22, 469-478. PubMed  Europe PubMed DOI  I
  165. Schefe,J.H., Neumann,C., Goebel,M., Danser,J., Kirsch,S., Gust,R., Kintscher,U., Unger,T. and Funke-Kaiser,H.
    Prorenin engages the (pro)renin receptor like renin and both ligand activities are unopposed by aliskiren
    J Hypertens (2008) 26, 1787-1794. PubMed  Europe PubMed DOI  I
  166. Takahashi,S., Hori,K., Shinbo,M., Hiwatashi,K., Gotoh,T. and Yamada,S.
    Isolation of human renin inhibitor from soybean: soyasaponin I is the novel human renin inhibitor in soybean
    Biosci Biotechnol Biochem (2008) 72, 3232-3236. PubMed  Europe PubMed DOI
  167. Uddin,M.N., Nabi,A.H., Nakagawa,T., Ichihara,A., Inagami,T. and Suzuki,F.
    Non-proteolytic activation of prorenin: activation by (pro)renin receptor and its inhibition by a prorenin prosegment, "decoy peptide"
    Front Biosci (2008) 13, 745-753. PubMed  Europe PubMed DOI  V
  168. Wu,Z., Cappiello,M.G., Scott,B.B., Bukhtiyarov,Y. and McGeehan,G.M.
    Purification and characterization of recombinant human renin for X-Ray crystallization studies
    BMC Biochem (2008) 9, 19-19. PubMed  Europe PubMed DOI  PMC  EPMC  E
    169. 2007
  169. Achard,V., Boullu-Ciocca,S., Desbriere,R., Nguyen,G. and Grino,M.
    Renin receptor expression in human adipose tissue
    Am J Physiol Regul Integr Comp Physiol (2007) 292, R274-R282. PubMed  Europe PubMed DOI
  170. Brown,M.J.
    Renin: friend or foe?
    Heart (2007) 93, 1026-1033. PubMed  Europe PubMed DOI  V
  171. Bukhtiyarov,Y., Zecher,M., Panemangalore,R., Wu,Z., Bruno,J.G., Yuan,J., Xu,Z., Dillard,L.W., McGeehan,G.M., Harrison,R.K. and Scott,B.B.
    Cloning, characterization and site-directed mutagenesis of canine renin
    J Biochem (2007) 142, 671-680. PubMed  Europe PubMed DOI
  172. Dechend,R., Shagdarsuren,E., Gratze,P., Fiebeler,A., Pilz,B., Meiners,S., Derer,W., Feldman,D.L., Webb,R. and Muller,D.N.
    Low-dose renin inhibitor and low-dose AT(1)-receptor blocker therapy ameliorate target-organ damage in rats harbouring human renin and angiotensinogen genes
    J Renin Angiotensin Aldosterone Syst (2007) 8, 81-84. PubMed  Europe PubMed DOI  I
  173. Goschke,R., Stutz,S., Rasetti,V., Cohen,N.C., Rahuel,J., Rigollier,P., Baum,H.P., Forgiarini,P., Schnell,C.R., Wagner,T., Gruetter,M.G., Fuhrer,W., Schilling,W., Cumin,F., Wood,J.M. and Maibaum,J.
    Novel 2,7-dialkyl-substituted 5(S)-amino-4(S)-hydroxy-8-phenyl-octanecarboxamide transition state peptidomimetics are potent and orally active inhibitors of human renin
    J Med Chem (2007) 50, 4818-4831. PubMed  Europe PubMed DOI  I
  174. Holsworth,D.D., Jalaie,M., Belliotti,T., Cai,C., Collard,W., Ferreira,S., Powell,N.A., Stier,M., Zhang,E., McConnell,P., Mochalkin,I., Ryan,M.J., Bryant,J., Li,T., Kasani,A., Subedi,R., Maiti,S.N. and Edmunds,J.J.
    Discovery of 6-ethyl-2,4-diaminopyrimidine-based small molecule renin inhibitors
    Bioorg Med Chem Lett (2007) 17, 3575-3580. PubMed  Europe PubMed DOI  I
  175. Konoshita,T., Fuchs,S., Makino,Y., Wakahara,S. and Miyamori,I.
    A proximal direct repeat motif characterized as a negative regulatory element in the human renin gene
    J Cell Biochem (2007) 102, 1043-1050. PubMed  Europe PubMed DOI
  176. Leibovitz,E. and Schiffrin,E.L.
    Novel drugs targeting hypertension: renin inhibitors and beyond
    J Cardiovasc Pharmacol (2007) 50, 3-8. PubMed  Europe PubMed DOI  V  I
  177. Li,Y.C.
    Inhibition of renin: an updated review of the development of renin inhibitors
    Curr Opin Investig Drugs (2007) 8, 750-757. PubMed  Europe PubMed  V  I
  178. Maas,M.H., Cransberg,K., van Grotel,M., Pieters,R. and Heuvel-Eibrink,M.M.
    Renin-induced hypertension in Wilms tumor patients
    Pediatr Blood Cancer (2007) 48, 500-503. PubMed  Europe PubMed DOI
  179. Maibaum,J., Stutz,S., Goschke,R., Rigollier,P., Yamaguchi,Y., Cumin,F., Rahuel,J., Baum,H.P., Cohen,N.C., Schnell,C.R., Fuhrer,W., Gruetter,M.G., Schilling,W. and Wood,J.M.
    Structural modification of the P2' position of 2,7-dialkyl-substituted 5(S)-amino-4(S)-hydroxy-8-phenyl-octanecarboxamides: the discovery of aliskiren, a potent nonpeptide human renin inhibitor active after once daily dosing in marmosets
    J Med Chem (2007) 50, 4832-4844. PubMed  Europe PubMed DOI  I
  180. Moore,N., Dicker,P., O'Brien,J.K., Stojanovic,M., Conroy,R.M., Treumann,A., O'Brien,E.T., Fitzgerald,D., Shields,D. and Stanton,A.V.
    Renin gene polymorphisms and haplotypes, blood pressure, and responses to renin-angiotensin system inhibition
    Hypertension (2007) 50, 340-347. PubMed  Europe PubMed DOI  M
  181. Nakagawa,T., Nishiuchi,K., Akaki,J., Iwata,H., Satou,R., Suzuki,F. and Nakamura,Y.
    Efficient production of recombinant human (pro)renin utilizing a decahistidine tag attached at the C-terminus
    Biosci Biotechnol Biochem (2007) 71, 256-260. PubMed  Europe PubMed DOI  E
  182. Nakagawa,T., Akaki,J., Satou,R., Takaya,M., Iwata,H., Katsurada,A., Nishiuchi,K., Ohmura,Y., Suzuki,F. and Nakamura,Y.
    The His-Pro-Phe motif of angiotensinogen is a crucial determinant of the substrate specificity of renin
    Biol Chem (2007) 388, 237-246. PubMed  Europe PubMed DOI  P
  183. Nurun,N.A., Uddin,N.M., Nakagawa,T., Iwata,H., Ichihara,A., Inagami,T. and Suzuki,F.
    Role of "handle" region of prorenin prosegment in the non-proteolytic activation of prorenin by binding to membrane anchored (pro)renin receptor
    Front Biosci (2007) 12, 4810-4817. PubMed  Europe PubMed DOI
  184. Pool,J.L.
    Direct renin inhibition: focus on aliskiren
    J Manag Care Pharm (2007) 13, 21-33. PubMed  Europe PubMed  I
  185. Powell,N.A., Ciske,F.L., Cai,C., Holsworth,D.D., Mennen,K., Van Huis,C.A., Jalaie,M., Day,J., Mastronardi,M., McConnell,P., Mochalkin,I., Zhang,E., Ryan,M.J., Bryant,J., Collard,W., Ferreira,S., Gu,C., Collins,R. and Edmunds,J.J.
    Rational design of 6-(2,4-diaminopyrimidinyl)-1,4-benzoxazin-3-ones as small molecule renin inhibitors
    Bioorg Med Chem (2007) 15, 5912-5949. PubMed  Europe PubMed DOI  I
  186. Ram,C.V.
    Direct renin inhibitors: a new approach to antihypertensive drug treatment
    J Clin Hypertens (Greenwich) (2007) 9, 615-621. PubMed  Europe PubMed DOI
  187. Reid,A.C., Silver,R.B. and Levi,R.
    Renin: at the heart of the mast cell
    Immunol Rev (2007) 217, 123-140. PubMed  Europe PubMed DOI
  188. Sarver,R.W., Peevers,J., Cody,W.L., Ciske,F.L., Dyer,J., Emerson,S.D., Hagadorn,J.C., Holsworth,D.D., Jalaie,M., Kaufman,M., Mastronardi,M., McConnell,P., Powell,N.A., Quin,J., III, Van Huis,C.A., Zhang,E. and Mochalkin,I.
    Binding thermodynamics of substituted diaminopyrimidine renin inhibitors
    Anal Biochem (2007) 360, 30-40. PubMed  Europe PubMed DOI  I
  189. Schweda,F., Friis,U., Wagner,C., Skott,O. and Kurtz,A.
    Renin release
    Physiology (Bethesda) (2007) 22, 310-319. PubMed  Europe PubMed DOI  V
  190. Suzuki,F.
    Spotlight on renin: nonproteolytic activation of prorenin by the (pro)renin receptor is blocked by decoy peptide
    J Renin Angiotensin Aldosterone Syst (2007) 8, 101-103. PubMed  Europe PubMed DOI
  191. Takahashi,S., Hata,K., Kikuchi,K. and Gotoh,T.
    High-level expression of recombinant active human renin in Sf-9 cells: rapid purification and characterization
    Biosci Biotechnol Biochem (2007) 71, 2610-2613. PubMed  Europe PubMed DOI  E
  192. Van Tassell,B.W. and Munger,M.A.
    Aliskiren for renin inhibition: a new class of antihypertensives
    Ann Pharmacother (2007) 41, 456-464. PubMed  Europe PubMed DOI  I
    193. 2006
  193. Azizi,M.
    Renin inhibition
    Curr Opin Nephrol Hypertens (2006) 15, 505-510. PubMed  Europe PubMed DOI  V  I
  194. [YEAR:19-12-2006]Bernstein,K.E.
    Views of the renin-angiotensin system: brilling, mimsy, and slithy tove
    Hypertension (19-12-2006) 47, 509-514. PubMed  Europe PubMed DOI  V
  195. Burckle,C. and Bader,M.
    Prorenin and its ancient receptor
    Hypertension (2006) 48, 549-551. PubMed  Europe PubMed DOI
  196. Ferro,A., Gilbert,R. and Krum,H.
    Importance of renin in blood pressure regulation and therapeutic potential of renin inhibition
    Int J Clin Pract (2006) 60, 577-581. PubMed  Europe PubMed DOI  I
  197. [YEAR:7-2-2006]Holsworth,D.D., Cai,C., Cheng,X.M., Cody,W.L., Downing,D.M., Erasga,N., Lee,C., Powell,N.A., Edmunds,J.J., Stier,M., Jalaie,M., Zhang,E., McConnell,P., Ryan,M.J., Bryant,J., Li,T., Kasani,A., Hall,E., Subedi,R., Rahim,M. and Maiti,S.
    Ketopiperazine-based renin inhibitors: optimization of the "C" ring
    Bioorg Med Chem Lett (7-2-2006) 16, 2500-2504. PubMed  Europe PubMed DOI  I
  198. Kalus,J.S.
    Aliskiren: a novel oral renin inhibitor for the treatment of hypertension
    Formulary (2006) 41, 631-638.  I
  199. Kushiro,T., Itakura,H., Abo,Y., Gotou,H., Terao,S. and Keefe,D.L.
    Aliskiren, a novel oral renin inhibitor, provides dose-dependent efficacy and placebo-like tolerability in Japanese patients with hypertension
    Hypertens Res (2006) 29, 997-1005. PubMed  Europe PubMed DOI  I
  200. Le,T.H. and Coffman,T.M.
    A new cardiac MASTer switch for the renin-angiotensin system
    J Clin Invest (2006) 116, 866-869. PubMed  Europe PubMed DOI  PMC  EPMC
  201. Luft,F.C.
    Achieving the goal of optimised renin system suppression: preclinical experience with a direct renin inhibitor
    J Renin Angiotensin Aldosterone Syst (2006) 7 Suppl 2, S12-S15.  I
  202. Muller,D.N. and Luft,F.C.
    Direct renin inhibition with aliskiren in hypertension and target organ damage
    Clin J Am Soc Nephrol (2006) 1, 221-228. PubMed  Europe PubMed DOI  I
  203. Nabi,A.H., Kageshima,A., Uddin,M.N., Nakagawa,T., Park,E.Y. and Suzuki,F.
    Binding properties of rat prorenin and renin to the recombinant rat renin/prorenin receptor prepared by a baculovirus expression system
    Int J Mol Med (2006) 18, 483-488. PubMed  Europe PubMed
  204. Scott,B.B., McGeehan,G.M. and Harrison,R.K.
    Development of inhibitors of the aspartyl protease renin for the treatment of hypertension
    Curr Protein Pept Sci (2006) 7, 241-254. PubMed  Europe PubMed DOI  V  I
  205. Staessen,J.A., Li,Y. and Richart,T.
    Oral renin inhibitors
    Lancet (2006) 368, 1449-1456. PubMed  Europe PubMed DOI  I
  206. Takahashi,S., Ogasawara,H., Watanabe,T., Kumagai,M., Inoue,H. and Hori,K.
    Refolding and activation of human prorenin expressed in Escherichia coli: application of recombinant human renin for inhibitor screening
    Biosci Biotechnol Biochem (2006) 70, 2913-2918. PubMed  Europe PubMed DOI  E
  207. Tice,C.M.
    Renin inhibitors
    Annu Rep Med Chem (2006) 41, 155-167. DOI  V  I
    208. 2005
  208. Fisher,N.D. and Hollenberg,N.K.
    Renin inhibition: what are the therapeutic opportunities?
    J Am Soc Nephrol (2005) 16, 592-599. PubMed  Europe PubMed DOI  V
  209. [YEAR:1-3-2005]Gradman,A.H., Schmieder,R.E., Lins,R.L., Nussberger,J., Chiang,Y. and Bedigian,M.P.
    Aliskiren, a novel orally effective renin inhibitor, provides dose-dependent antihypertensive efficacy and placebo-like tolerability in hypertensive patients
    Circulation (1-3-2005) 111, 1012-1018. PubMed  Europe PubMed DOI  I
  210. [YEAR:1-4-2005]Holsworth,D.D., Powell,N.A., Downing,D.M., Cai,C., Cody,W.L., Ryan,J.M., Ostroski,R., Jalaie,M., Bryant,J.W. and Edmunds,J.J.
    Discovery of novel non-peptidic ketopiperazine-based renin inhibitors
    Bioorg Med Chem (1-4-2005) 13, 2657-2664. PubMed  Europe PubMed DOI  I
  211. Leckie,B.J.
    Targeting the renin-angiotensin system: what's new?
    Curr Med Chem Cardiovasc Hematol Agents (2005) 3, 23-32. PubMed  Europe PubMed DOI  V
  212. Nabi,A.H., Uddin,M.N., Nakagawa,T., Orihashi,T., Ebihara,A., Iwasawa,A., Nakamura,Y. and Suzuki,F.
    Roles of His9 (P2 subsite) and His13 (P3' subsite) in angiotensinogen for catalytic reaction of renin
    Int J Mol Med (2005) 16, 103-107. PubMed  Europe PubMed
  213. [YEAR:15-11-2005]Pan,L. and Gross,K.W.
    Transcriptional regulation of renin: an update
    Hypertension (15-11-2005) 45, 3-8. PubMed  Europe PubMed DOI  V
  214. Paruszewski,R., Jaworski,P., Bodnar,M., Dudkiewicz-Wilczynska,J. and Roman,I.
    New renin inhibitors containing pseudodipeptidic units in P3-P2 and P1-P1' positions
    Chem Pharm Bull (Tokyo) (2005) 53, 1305-1309. PubMed  Europe PubMed DOI  I
  215. [YEAR:2-5-2005]Powell,N.A., Clay,E.H., Holsworth,D.D., Bryant,J.W., Ryan,M.J., Jalaie,M., Zhang,E. and Edmunds,J.J.
    Equipotent activity in both enantiomers of a series of ketopiperazine-based renin inhibitors
    Bioorg Med Chem Lett (2-5-2005) 15, 2371-2374. PubMed  Europe PubMed DOI  I
  216. [YEAR:2-9-2005]Powell,N.A., Clay,E.H., Holsworth,D.D., Bryant,J.W., Ryan,M.J., Jalaie,M. and Edmunds,J.J.
    Benzyl ether structure-activity relationships in a series of ketopiperazine-based renin inhibitors
    Bioorg Med Chem Lett (2-9-2005) 15, 4713-4716. PubMed  Europe PubMed DOI  I
  217. [YEAR:3-3-2005]Ramser,J., Abidi,F.E., Burckle,C.A., Lenski,C., Toriello,H., Wen,G., Lubs,H.A., Engert,S., Stevenson,R.E., Meindl,A., Schwartz,C.E. and Nguyen,G.
    A unique exonic splice enhancer mutation in a family with X-linked mental retardation and epilepsy points to a novel role of the renin receptor
    Hum Mol Genet (3-3-2005) 14, 1019-1027. PubMed  Europe PubMed DOI
  218. [YEAR:2-5-2005]Van Epps,H.L.
    Harry Goldblatt and the discovery of renin
    J Exp Med (2-5-2005) 201, 1351-1351. PubMed  Europe PubMed  PMC  EPMC
  219. Wang,X., Sun,Z. and Cade,R.
    Prolonged attenuation of cold-induced hypertension by adenoviral delivery of renin antisense
    Kidney Int (2005) 68, 680-687. PubMed  Europe PubMed DOI
  220. Wood,J.M., Schnell,C.R., Cumin,F., Menard,J. and Webb,R.L.
    Aliskiren, a novel, orally effective renin inhibitor, lowers blood pressure in marmosets and spontaneously hypertensive rats
    J Hypertens (2005) 23, 417-426. PubMed  Europe PubMed DOI  I
    221. 2004
  221. Hansen,P.B., Yang,T., Huang,Y., Mizel,D., Briggs,J. and Schnermann,J.
    Plasma renin in mice with one or two renin genes
    Acta Physiol Scand (2004) 181, 431-437. PubMed  Europe PubMed DOI
  222. Ichihara,A., Hayashi,M., Kaneshiro,Y., Suzuki,F., Nakagawa,T., Tada,Y., Koura,Y., Nishiyama,A., Okada,H., Uddin,M.N., Nabi,A.H., Ishida,Y., Inagami,T. and Saruta,T.
    Inhibition of diabetic nephropathy by a decoy peptide corresponding to the "handle" region for nonproteolytic activation of prorenin
    J Clin Invest (2004) 114, 1128-1135. PubMed  Europe PubMed DOI  PMC  EPMC
  223. [YEAR:25-11-2004]Liang,P., Jones,C.A., Bisgrove,B.W., Song,L., Glenn,S.T., Yost,H.J. and Gross,K.W.
    Genomic characterization and expression analysis of the first nonmammalian renin genes from zebrafish and pufferfish
    Physiol Genomics (25-11-2004) 16, 314-322. PubMed  Europe PubMed DOI
  224. Nguyen,G. and Burckle,C.A.
    [The (pro)renin receptor: biology and functional significance]
    Bull Acad Natl Med (2004) 188, 621-628. PubMed  Europe PubMed
  225. Nguyen,G., Burckle,C.A. and Sraer,J.D.
    Renin/prorenin-receptor biochemistry and functional significance
    Curr Hypertens Rep (2004) 6, 129-132. PubMed  Europe PubMed
  226. [YEAR:3-2-2004]Pan,L., Jones,C.A., Glenn,S.T. and Gross,K.W.
    Identification of a novel region in the proximal promoter of the mouse renin gene critical for expression
    Am J Physiol Renal Physiol (3-2-2004) 286, F1107-F1115. PubMed  Europe PubMed DOI
  227. [YEAR:2-7-2004]Paschalidou,K., Neumann,U., Gerhartz,B. and Tzougraki,C.
    Highly sensitive intramolecularly quenched fluorogenic substrates for renin based on the combination of L-2-amino-3-(7-methoxy-4-coumaryl)propionic acid with 2,4-dinitrophenyl groups at various positions
    Biochem J (2-7-2004) 382, 1031-1038. PubMed  Europe PubMed DOI  PMC  EPMC  A
  228. [YEAR:14-9-2004]Silver,R.B., Reid,A.C., Mackins,C.J., Askwith,T., Schaefer,U., Herzlinger,D. and Levi,R.
    Mast cells: a unique source of renin
    Proc Natl Acad Sci U S A (14-9-2004) 101, 13607-13612. PubMed  Europe PubMed DOI  PMC  EPMC
  229. Suzuki,F., Murakami,K., Nakamura,Y. and Inagami,T.
    Renin
    [ISSN:0-12-079610-4] (2004) 2, 54-61.  V
    230. 2003
  230. Lavoie,J.L. and Sigmund,C.D.
    Minireview: overview of the renin-angiotensin system - an endocrine and paracrine system
    Endocrinology (2003) 144, 2179-2183. PubMed  Europe PubMed DOI  V
  231. Maibaum,J. and Feldman,D.L.
    Renin inhibitors as novel treatments for cardiovascular disease
    Expert Opin Ther Pat (2003) 13, 589-603.  I
  232. Morris,B.J.
    Renin: from 'pro' to promoter
    Bioessays (2003) 25, 520-527. PubMed  Europe PubMed DOI
  233. Persson,P.B., Skalweit,A., Mrowka,R. and Thiele,B.J.
    Control of renin synthesis
    Am J Physiol Regul Integr Comp Physiol (2003) 285, R491-R497. PubMed  Europe PubMed DOI
  234. [YEAR:1-11-2003]Persson,P.B.
    Renin: origin, secretion and synthesis
    J Physiol (1-11-2003) 552, 667-671. PubMed  Europe PubMed DOI  PMC  EPMC
  235. Pursell,R.N. and Quinlan,P.M.
    Secondary hypertension due to a renin-producing teratoma
    Am J Hypertens (2003) 16, 592-595. PubMed  Europe PubMed DOI
  236. [YEAR:20-6-2003]Suzuki,F., Hayakawa,M., Nakagawa,T., Nasir,U.M., Ebihara,A., Iwasawa,A., Ishida,Y., Nakamura,Y. and Murakami,K.
    Human prorenin has "gate and handle" regions for its non-proteolytic activation
    J Biol Chem (20-6-2003) 278, 22217-22222. PubMed  Europe PubMed DOI
  237. [YEAR:5-9-2003]Wood,J.M., Maibaum,J., Rahuel,J., Grutter,M.G., Cohen,N.C., Rasetti,V., Ruger,H., Goschke,R., Stutz,S., Fuhrer,W., Schilling,W., Rigollier,P., Yamaguchi,Y., Cumin,F., Baum,H.P., Schnell,C.R., Herold,P., Mah,R., Jensen,C., O'Brien,E., Stanton,A. and Bedigian,M.P.
    Structure-based design of aliskiren, a novel orally effective renin inhibitor
    Biochem Biophys Res Commun (5-9-2003) 308, 698-705. PubMed  Europe PubMed DOI  S  I
    238. 2002
  238. [YEAR:11-6-2002]Caron,K.M., James,L.R., Kim,H.S., Morham,S.G., Sequeira Lopez,M.L., Gomez,R.A., Reudelhuber,T.L. and Smithies,O.
    A genetically clamped renin transgene for the induction of hypertension
    Proc Natl Acad Sci U S A (11-6-2002) 99, 8248-8252. PubMed  Europe PubMed DOI  PMC  EPMC
  239. Fuchs,S., Germain,S., Philippe,J., Corvol,P. and Pinet,F.
    Expression of renin in large arteries outside the kidney revealed by human renin promoter/LacZ transgenic mouse
    Am J Pathol (2002) 161, 717-725. PubMed  Europe PubMed DOI  PMC  EPMC
  240. Prescott,G., Silversides,D.W. and Reudelhuber,T.L.
    Tissue activity of circulating prorenin
    Am J Hypertens (2002) 15, 280-285. PubMed  Europe PubMed DOI
  241. Yabuki,A., Suzuki,S., Matsumoto,M., Taniguchi,K. and Nishinakagawa,H.
    A simple method for the specific detection of Ren-1 renin
    Kidney Int (2002) 62, 2294-2299. PubMed  Europe PubMed DOI
    242. 2001
  242. Leckie,B.J.
    Polymorphisms of the renin gene promoter in spontaneously hypertensive and Wistar-Kyoto rats
    Clin Exp Pharmacol Physiol (2001) 28, 60-63. PubMed  Europe PubMed DOI  M
  243. Saris,J.J., Derkx,F.H., De Bruin,R.J., Dekkers,D.H., Lamers,J.M., Saxena,P.R., Schalekamp,M.A. and Danser,A.H.J.
    High-affinity prorenin binding to cardiac man-6-P/IGF-II receptors precedes proteolytic activation to renin
    Am J Physiol Heart Circ Physiol (2001) 280, H1706-H1715. PubMed  Europe PubMed
  244. [YEAR:2-2-2001]Shi,Q., Gross,K.W. and Sigmund,C.D.
    Retinoic acid-mediated activation of the mouse renin enhancer
    J Biol Chem (2-2-2001) 276, 3597-3603. PubMed  Europe PubMed DOI
  245. van den Eijnden,M.M., Saris,J.J., De Bruin,R.J., de Wit,E., Sluiter,W., Reudelhuber,T.L., Schalekamp,M.A., Derkx,F.H. and Danser,A.H.
    Prorenin accumulation and activation in human endothelial cells: importance of mannose 6-phosphate receptors
    Arterioscler Thromb Vasc Biol (2001) 21, 911-916. PubMed  Europe PubMed
    246. 2000
  246. Rahuel,J., Rasetti,V., Maibaum,J., Rueger,H., Goschke,R., Cohen,N.C., Stutz,S., Cumin,F., Fuhrer,W., Wood,J.M. and Grutter,M.G.
    Structure-based drug design: the discovery of novel nonpeptide orally active inhibitors of human renin
    Chem Biol (2000) 7, 493-504. PubMed  Europe PubMed DOI  I
  247. [YEAR:29-6-2000]Sinn,P.L. and Sigmund,C.D.
    Identification of three human renin mRNA isoforms from alternative tissue-specific transcriptional initiation
    Physiol Genomics (29-6-2000) 3, 25-31. PubMed  Europe PubMed
  248. [YEAR:19-1-2000]Suzuki,F., Nakagawa,T., Kakidachi,H., Murakami,K., Inagami,T. and Nakamura,Y.
    The dominant role of the prosegment of prorenin in determining the rate of activation by acid or trypsin: Studies with molecular chimeras
    Biochem Biophys Res Commun (19-1-2000) 267, 577-580. PubMed  Europe PubMed DOI
  249. Zimmerman,B.G.
    Greater blood pressure-lowering effect of the renin inhibitor EMD 58265 than an angiotensin-converting enzyme inhibitor in two-kidney one-clip Goldblatt rabbit
    Clin Exp Pharmacol Physiol (2000) 27, 370-377. PubMed  Europe PubMed DOI  I
    250. 1999
  250. Admiraal,P.J., van Kesteren,C.A., Danser,A.H., Derkx,F.H., Sluiter,W. and Schalekamp,M.A.
    Uptake and proteolytic activation of prorenin by cultured human endothelial cells
    J Hypertens (1999) 17, 621-629. PubMed  Europe PubMed DOI
  251. Frossard,P.M., Lestringant,G.G., Malloy,M.J. and Kane,J.P.
    Human renin gene BglI dimorphism associated with hypertension in two independent populations
    Clin Genet (1999) 56, 428-433. PubMed  Europe PubMed DOI
  252. Germain,S., Bonnet,F., Fuchs,S., Philippe,J., Corvol,P. and Pinet,F.
    Dissection of silencer elements in first intron controlling the human renin gene
    J Hypertens (1999) 17, 899-905. PubMed  Europe PubMed DOI
  253. [YEAR:22-1-1999]Jutras,I. and Reudelhuber,T.L.
    Prorenin processing by cathepsin B in vitro and in transfected cells
    FEBS Lett (22-1-1999) 443, 48-52. PubMed  Europe PubMed DOI
  254. Nasir,U.M., Suzuki,F., Nagai,T., Nakagawa,T. and Nakamura,Y.
    Tyrosine-83 of human renin contributes to biphasic pH dependence of the renin-angiotensinogen reaction
    Biosci Biotechnol Biochem (1999) 63, 1143-1145. PubMed  Europe PubMed
  255. Oefner,C., Binggeli,A., Breu,V., Bur,D., Clozel,J.P., D'arcy,A., Dorn,A., Fischli,W., Gruninger,F., Guller,R., Hirth,G., Marki,H., Mathews,S., ller,M., Ridley,R.G., Stadler,H., Vieira,E., Wilhelm,M., Winkler,F. and Wostl,W.
    Renin inhibition by substituted piperidines: a novel paradigm for the inhibition of monomeric aspartic proteinases?
    Chem Biol (1999) 6, 127-131. PubMed  Europe PubMed DOI
  256. Valdenaire,O., Breu,V., Giller,T., Bur,D. and Fischli,W.
    Cloning and characterization of marmoset renin: comparison with human renin
    J Cardiovasc Pharmacol (1999) 34, 893-897. PubMed  Europe PubMed DOI
    257. 1998
  257. [YEAR:10-11-1998]Deinum,J., Derkx,F.H. and Schalekamp,M.A.
    Probing epitopes on human prorenin during its proteolytic and non-proteolytic activation
    Biochim Biophys Acta (10-11-1998) 1388, 386-396. PubMed  Europe PubMed DOI  I
  258. [YEAR:25-9-1998]Germain,S., Bonnet,F., Philippe,J., Fuchs,S., Corvol,P. and Pinet,F.
    A novel distal enhancer confers chorionic expression on the human renin gene
    J Biol Chem (25-9-1998) 273, 25292-25300. PubMed  Europe PubMed DOI
  259. Inagami,T.
    A memorial to Robert Tiegerstedt: the centennial of renin discovery
    Hypertension (1998) 32, 953-957. PubMed  Europe PubMed
  260. Kikkawa,Y., Yamanaka,N., Tada,J., Kanamori,N., Tsumura,K. and Hosoi,K.
    Prorenin processing and restricted endoproteolysis by mouse tissue kallikrein family enzymes (MK1, MK9, MK13, and MK22)
    Biochim Biophys Acta (1998) 1382, 55-64. PubMed  Europe PubMed DOI
    261. 1997
  261. Salzet,M. and Stefano,G.
    A renin-like enzyme in the leech Theromyzon tessulatum
    Mol Cell Endocrinol (1997) 131, 1-8. PubMed  Europe PubMed DOI
  262. Sueiras-Diaz,J., Jones,D.M., Szelke,M., Leckie,B.J., Beattie,S.R., Beattie,C. and Morton,J.J.
    Potent in vivo inhibitors of rat renin: analogues of human and rat angiotensinogen sequences containing different classes of pseudodipeptides at the scissile site
    J Pept Res (1997) 50, 239-247. PubMed  Europe PubMed  I
  263. Tokarski,J.S. and Hopfinger,A.J.
    Prediction of ligand-receptor binding thermodynamics by free energy force field (FEFF) 3D-QSAR analysis: application to a set of peptidometic renin inhibitors
    J Chem Inf Comput Sci (1997) 37, 792-811. PubMed  Europe PubMed  I
    264. 1996
  264. De Vito,E., Martinez de Melian,E.R. and Guardia,D.C.
    Activation of renal renin by a protein plasma fraction: a novel enzymatic mechanism
    Comp Biochem Physiol B Biochem Mol Biol (1996) 113, 433-438. PubMed  Europe PubMed DOI
  265. LaPlante,S.R., Tong,L., Aubry,N., Pav,S., Jung,G. and Anderson,P.C.
    Several polyhydroxymonoamide renin inhibitors assume similar conformations in the unbound and renin-bound states
    Int J Pept Protein Res (1996) 48, 401-410. PubMed  Europe PubMed  I
  266. Mathews,S., Dobeli,H., Pruschy,M., Bosser,R., D'arcy,A., Oefner,C., Zulauf,M., Gentz,R., Breu,V., Matile,H., Schlaeger,J. and Fischli,W.
    Recombinant human renin produced in different expression systems: biochemical properties and 3D structure
    Protein Expr Purif (1996) 7, 81-91. PubMed  Europe PubMed DOI  E  S  I
    267. 1995
  267. Aguilar,C.F., Dhanaraj,V., Guruprasad,K., Dealwis,C., Badasso,M., Cooper,J.B., Wood,S.P. and Blundell,T.L.
    Comparisons of the three-dimensional structures, specificities and glycosylation of renins, yeast proteinase A and cathepsin D
    Adv Exp Med Biol (1995) 362, 155-166. PubMed  Europe PubMed
  268. Menard,J., Boger,R.S., Moyse,D.M., Guyene,T.T., Glassman,H.N. and Kleinert,H.D.
    Dose-dependent effects of the renin inhibitor zankiren HCl after a single oral dose in mildly sodium-depleted normotensive subjects
    Circulation (1995) 91, 330-338. PubMed  Europe PubMed  I
  269. Morris,B.J.
    Some physiological outcomes of renin gene studies
    Clin Exp Pharmacol Physiol (1995) 22, 966-975. PubMed  Europe PubMed
  270. Tong,L., Pav,S., Lamarre,D., Pilote,L., Laplante,S., Anderson,P.C. and Jung,G.
    High resolution crystal structures of recombinant human renin in complex with polyhydroxymonoamide inhibitors
    J Mol Biol (1995) 250, 211-222. PubMed  Europe PubMed DOI  S  I
  271. Tong,L., Pav,S., Lamarre,D., Simoneau,B., Lavallee,P. and Jung,G.
    Crystallographic studies on the binding modes of P2-P3 butanediamide renin inhibitors
    J Biol Chem (1995) 270, 29520-29524. PubMed  Europe PubMed DOI  S  I
    272. 1994
  272. Hatae,T., Takimoto,E., Murakami,K. and Fukamizu,A.
    Comparative studies on species-specific reactivity between renin and angiotensinogen
    Mol Cell Biochem (1994) 131, 43-47. PubMed  Europe PubMed  P
  273. Mangiapane,M.L., MacAndrew,J.T., Ellery,S.S., Smith,A.H., Purcell,I.M., Kleinman,E.F., Holt,W.F. and Murphy,W.R.
    CP-71,362: a pentapeptide renin inhibitor selective for the canine enzyme
    Clin Exp Hypertens (1994) 16, 507-533. PubMed  Europe PubMed DOI  I
  274. Shinagawa,T., Nakayama,K., Uchiyama,Y., Kominami,E., Doi,Y., Hashiba,K., Yano,K., Hseu,W.A. and Murakami,K.
    Role of cathepsin B as prorenin processing enzyme in human kidney
    Hypertens Res (1994) 18, 131-136.
  275. [YEAR:6-12-1994]Wang,W. and Liang,T.C.
    Substrate specificity of porcine renin: P1', P1, and P3 residues of renin substrates are crucial for activity
    Biochemistry (6-12-1994) 33, 14636-14641. PubMed  Europe PubMed DOI  P
  276. Wood,J.M., Cumin,F. and Maibaum,J.
    Pharmacology of renin inhibitors and their application to the treatment of hypertension
    Pharmacol Ther (1994) 61, 325-344. PubMed  Europe PubMed DOI  I
    277. 1993
  277. Rao,C., Scarborough,P.E., Lowther,W.T., Kay,J., Batley,B., Rapundalo,S., Klutchko,S., Taylor,M.D. and Dunn,B.M.
    Structure-function database for active site binding to the aspartic proteinases
    Adv Exp Med Biol (1993) 306, 143-147.
    278. 1992
  278. [YEAR:15-11-1992]Derkx,F.H., Deinum,J., Lipovski,M., Verhaar,M., Fischli,W. and Schalekamp,M.A.
    Nonproteolytic "activation" of prorenin by active site-directed renin inhibitors as demonstrated by renin-specific monoclonal antibody
    J Biol Chem (15-11-1992) 267, 22837-22842. PubMed  Europe PubMed
  279. Dhanaraj,V., Dealwis,C.G., Frazao,C., Badasso,M., Sibanda,B.L., Tickle,I.J., Cooper,J.B., Driessen,H.P.C., Newman,M., Aguilar,C., Wood,S.P., Blundell,T.L., Hobart,P.M., Geoghegan,K.F., Ammirati,M.J., Danley,D.E., O'Connor,B.A. and Hoover,D.J.
    X-ray analyses of peptide-inhibitor complexes define the structural basis of specificity for human and mouse renins
    Nature (1992) 357, 466-472. PubMed  Europe PubMed DOI  S
  280. [YEAR:15-8-1992]Ganten,D., Wagner,J., Zeh,K., Bader,M., Michel,J.B., Paul,M., Zimmermann,F., Ruf,P., Hilgenfeldt,U. and Ganten,U.
    Species specificity of renin kinetics in transgenic rats harboring the human renin and angiotensinogen genes
    Proc Natl Acad Sci U S A (15-8-1992) 89, 7806-7810. PubMed  Europe PubMed  PMC  EPMC  I
  281. Murakami,E., Kokubu,T., Ii,Y., Hiwada,K., Muramatsu,S., Takahagi,H. and Salmon,P.F.
    Effects of repeated oral administration of renin inhibitor ES-8891 on the renin-angiotensin system in human subjects
    Hypertens Res (1992) 15, 41-44. DOI  I
  282. [YEAR:15-5-1992]Oliveira,M.C., Hirata,I.Y., Chagas,J.R., Boschcov,P., Gomes,R.A., Figueiredo,A.F. and Juliano,L.
    Intramolecularly quenched fluorogenic peptide substrates for human renin
    Anal Biochem (15-5-1992) 203, 39-46. PubMed  Europe PubMed DOI
  283. [YEAR:15-6-1992]Pitarresi,T.M., Rubattu,S., Heinrikson,R. and Sealey,J.E.
    Reversible cryoactivation of recombinant human prorenin
    J Biol Chem (15-6-1992) 267, 11753-11759. PubMed  Europe PubMed
  284. Yamauchi,T., Suzuki,F., Takahashi,A., Tsutsumi,I., Hori,H., Watanabe,T., Ishizuka,Y., Nakamura,Y. and Murakami,K.
    Expression of rat renin in mammalian cells and its purification
    Clin Exp Hypertens A (1992) 14, 377-392. PubMed  Europe PubMed  E
    285. 1991
  285. Doi,M., In,Y., Inoue,M., Ishida,T., Iizuka,K., Akahane,K., Harada,H., Umeyama,H. and Kiso,Y.
    Conformational study of a potent human renin inhibitor: X-ray crystal structure of isopropyl (2R,3S)-4-cyclohexyl- 2- hydroxy-3-{N-[(2R)-2-morpholinocarbonylmethyl-3-(1- naphthyl)propionyl]-L-histidylamino}butyrate (KRI-1314), a pentapeptide analogue with amino acid sequence corresponding to the cleavage site of angiotensinogen
    Chem Soc J [Perkin 1] (1991) 1991, 1153-1158.  S  I
  286. Fischli,W., Clozel,J.P., el Amrani,K., Wostl,W., Neidhart,W., Stadler,H. and Branca,Q.
    Ro 42-5892 is a potent orally active renin inhibitor in primates
    Hypertension (1991) 18, 22-31. PubMed  Europe PubMed  I
  287. Ido,E., Han,H.P., Kezdy,F.J. and Tang,J.
    Kinetic studies of human immunodeficiency virus type 1 protease and its active-site hydrogen bond mutant A28S
    J Biol Chem (1991) 266, 24359-24366. PubMed  Europe PubMed
  288. Ishizuka,Y., Shoda,A., Yoshida,S., Kawamura,Y., Haraguchi,K. and Murakami,K.
    Isolation and characterization of recombinant human prorenin in Chinese hamster ovary cells
    J Biochem (1991) 109, 30-35. PubMed  Europe PubMed
  289. [YEAR:15-4-1991]Kim,S., Hosoi,M., Kikuchi,N. and Yamamoto,K.
    Amino-terminal amino acid sequence and heterogeneity in glycosylation of rat renal renin
    J Biol Chem (15-4-1991) 266, 7044-7050. PubMed  Europe PubMed
  290. Pravenec,M., Simonet,L., Kren,V., Kunes,J., Levan,G., Szpirer,J., Szpirer,C. and Kurtz,T.
    The rat renin gene: assignment to chromosome 13 and linkage to the regulation of blood pressure
    Genomics (1991) 9, 466-472. PubMed  Europe PubMed
  291. Rahuel,J., Priestle,J.P. and Grutter,M.G.
    The crystal structures of recombinant glycosylated human renin alone and in complex with a transition state analog inhibitor
    J Struct Biol (1991) 107, 227-236. PubMed  Europe PubMed  S  I
    292. 1990
  292. Glassman,H.N., Kleinert,H.D., Boger,R.S., Moyse,D.M., Griffiths,A.N. and Luther,R.R.
    Clinical pharmacology of enalkiren, a novel, dipeptide renin inhibitor
    J Cardiovasc Pharmacol (1990) 16 Suppl 4, S76-S81. PubMed  Europe PubMed  I
  293. [YEAR:27-3-1990]Green,D.W., Aykent,S., Gierse,J.K. and Zupec,M.E.
    Substrate specificity of recombinant human renal renin: effect of histidine in the P2 subsite on pH dependence
    Biochemistry (27-3-1990) 29, 3126-3133. PubMed  Europe PubMed
  294. Greenlee,W.J.
    Renin inhibitors
    Med Res Rev (1990) 10, 173-236. PubMed  Europe PubMed  V  I
  295. Harada,H., Iyobe,A., Tsubaki,A., Yamaguchi,T., Hirata,K., Kamijo,T., Iizuka,K. and Kiso,Y.
    A practical synthesis of an orally potent renin inhibitor, isopropyl (2R,3S)-4-cyclohexyl-2-hydroxy-3-{N-[(2R)-2-morpholinocarbonylmethyl-3-(1- naphthyl)propionyl]-L-histidyl}aminobutyrate
    Chem Soc J [Perkin 1] (1990) 1, 2497-2500.  I
  296. Iizuka,K., Kamijo,T., Harada,H., Akahane,K., Kubota,T., Umeyama,H., Ishida,T. and Kiso,Y.
    Orally potent human renin inhibitors derived from angiotensinogen transition state: design, synthesis, and mode of interaction
    J Med Chem (1990) 33, 2707-2714. PubMed  Europe PubMed
  297. Kempf,D.J., de Lara,E., Stein,H.H., Cohen,J., Egan,D.A. and Plattner,J.J.
    Renin inhibitors based on dipeptide analogues. Incorporation of the hydroxyethylene isostere at the P2/P3 sites
    J Med Chem (1990) 33, 371-374. PubMed  Europe PubMed DOI  I
  298. Ohkubo,H., Kawakami,H., Kakehi,Y., Takumi,T., Arai,H., Yokota,Y., Iwai,M., Tanabe,Y., Masu,M. and Hata,J.
    Generation of transgenic mice with elevated blood pressure by introduction of the rat renin and angiotensinogen genes
    Proc Natl Acad Sci U S A (1990) 87, 5153-5157. PubMed  Europe PubMed DOI  PMC  EPMC
  299. Rosenberg,S.H., Dellaria,J.F., Kempf,D.J., Hutchins,C.W., Woods,K.W., Maki,R.G., de Lara,E., Spina,K.P., Stein,H.H. and Cohen,J.
    Potent, low molecular weight renin inhibitors containing a C-terminal heterocycle: hydrogen bonding at the active site
    J Med Chem (1990) 33, 1582-1590. PubMed  Europe PubMed DOI  I
  300. Shiratori,Y., Nakagawa,S., Hori,H., Murakami,K. and Umeyama,H.
    Protein modeling of human prorenin using the molecular dynamics method
    J Mol Graph (1990) 8, 163-167. PubMed  Europe PubMed  S
  301. Thaisrivongs,S., Mao,B., Pals,D.T., Turner,S.R. and Kroll,L.T.
    Renin inhibitory peptides. A beta-aspartyl residue as a replacement for the histidyl residue at the P-2 site
    J Med Chem (1990) 33, 1337-1343. PubMed  Europe PubMed
  302. Yamauchi,T., Nagahama,M., Watanabe,T., Ishizuka,Y., Hori,H. and Murakami,K.
    Site-directed mutagenesis of human prorenin. Substitution of three arginine residues in the propeptide with glutamine residues yields active prorenin
    J Biochem (1990) 107, 27-31. PubMed  Europe PubMed
    303. 1989
  303. [YEAR:5-5-1989]Burt,D.W., Nakamura,N., Kelley,P. and Dzau,V.J.
    Identification of negative and positive regulatory elements in the human renin gene
    J Biol Chem (5-5-1989) 264, 7357-7362. PubMed  Europe PubMed
  304. [YEAR:5-9-1989]Higashimori,K., Mizuno,K., Nakajo,S., Boehm,F.H., Marcotte,P.A., Egan,D.A., Holleman,W.H., Heusser,C., Poisner,A.M. and Inagami,T.
    Pure human inactive renin. Evidence that native inactive renin is prorenin
    J Biol Chem (5-9-1989) 264, 14662-14667. PubMed  Europe PubMed
  305. Inagami,T.
    Structure and function of renin
    J Hypertens Suppl (1989) 7, S3-S8. PubMed  Europe PubMed
  306. Sielecki,A.R., Hayakawa,K., Fujinaga,M., Murphy,M.E., Fraser,M., Muir,A.K., Carilli,C.T., Lewicki,J.A., Baxter,J.D. and James,M.N.
    Structure of recombinant human renin, a target for cardiovascular-active drugs, at 2.5 A resolution
    Science (1989) 243, 1346-1351. PubMed  Europe PubMed
  307. Wood,J.M., Criscione,L., de Gasparo,M., Buhlmayer,P., Rueger,H., Stanton,J.L., Jupp,R.A. and Kay,J.
    CGP 38 560: orally active, low-molecular-weight renin inhibitor with high potency and specificity
    J Cardiovasc Pharmacol (1989) 14, 221-226. PubMed  Europe PubMed  I
    308. 1988
  308. Yamauchi,T., Nagahama,M., Hori,H. and Murakami,K.
    Functional characterization of Asp-317 mutant of human renin expressed in COS cells
    FEBS Lett (1988) 230, 205-208. PubMed  Europe PubMed DOI
    309. 1987
  309. Bolis,G., Fung,A.K., Greer,J., Kleinert,H.D., Marcotte,P.A., Perun,T.J., Plattner,J.J. and Stein,H.H.
    Renin inhibitors. Dipeptide analogues of angiotensinogen incorporating transition-state, nonpeptidic replacements at the scissile bond
    J Med Chem (1987) 30, 1729-1737. PubMed  Europe PubMed  I
  310. Burnham,C.E., Hawelu-Johnson,C.L., Frank,B.M. and Lynch,K.R.
    Molecular cloning of rat renin cDNA and its gene
    Proc Natl Acad Sci U S A (1987) 84, 5605-5609. PubMed  Europe PubMed  PMC  EPMC
  311. [YEAR:25-2-1987]Derkx,F.H., Schalekamp,M.P. and Schalekamp,M.A.
    Two-step prorenin-renin conversion. Isolation of an intermediary form of activated prorenin
    J Biol Chem (25-2-1987) 262, 2472-2477. PubMed  Europe PubMed
  312. [YEAR:25-1-1987]Do,Y.S., Shinagawa,T., Tam,H., Inagami,T. and Hsueh,W.A.
    Characterization of pure human renal renin. Evidence for a subunit structure
    J Biol Chem (25-1-1987) 262, 1037-1043. PubMed  Europe PubMed
  313. Hui,K.Y., Carlson,W.D., Bernatowicz,M.S. and Haber,E.
    Analysis of structure-activity relationships in renin substrate analogue inhibitory peptides
    J Med Chem (1987) 30, 1287-1295. PubMed  Europe PubMed  I
  314. Kempf,D.J., de Lara,E., Stein,H.H., Cohen,J. and Plattner,J.J.
    Renin inhibitors based on novel dipeptide analogues. Incorporation of the dehydrohydroxyethylene isostere at the scissile bond
    J Med Chem (1987) 30, 1978-1983. PubMed  Europe PubMed  I
  315. Pinet,F., Mizrahi,J., Laboulandine,I., Menard,J. and Corvol,P.
    Regulation of prorenin secretion in cultured human transfected juxtaglomerular cells
    J Clin Invest (1987) 80, 724-731. PubMed  Europe PubMed DOI  PMC  EPMC
  316. Takada,Y., Maruta,H., Wagner,B., FA,X.G., James,H.L. and Erdos,E.G.
    Activation of human prorenin by neutrophil elastase
    J Clin Endocrinol Metab (1987) 65, 1225-1230. PubMed  Europe PubMed DOI
    317. 1986
  317. Poorman,R.A., Palermo,D.P., Post,L.E., Murakami,K., Kinner,J.H., Smith,C.W., Reardon,I. and Heinrikson,R.L.
    Isolation and characterization of native human renin derived from Chinese hamster ovary cells
    Proteins (1986) 1, 139-145. PubMed  Europe PubMed DOI
  318. Soubrier,F., Panthier,J.J., Houot,A.M., Rougeon,F. and Corvol,P.
    Segmental homology between the promoter region of the human renin gene and the mouse ren1 and ren2 promoter regions
    Gene (1986) 41, 85-92. PubMed  Europe PubMed
    319. 1985
  319. Boger,J., Payne,L.S., Perlow,D.S., Lohr,N.S., Poe,M., Blaine,E.H., Ulm,E.H., Schorn,T.W., LaMont,B.I. and Lin,T.Y.
    Renin inhibitors. Syntheses of subnanomolar, competitive, transition-state analogue inhibitors containing a novel analogue of statine
    J Med Chem (1985) 28, 1779-1790. PubMed  Europe PubMed  I
  320. Boger,J.
    Chapter 26. Renin Inhibition
    Annu Rep Med Chem (1985) 20, 257-266. DOI  I
  321. [YEAR:5-8-1985]Cumin,F., Evin,G., Fehrentz,J.A., Seyer,R., Castro,B., Menard,J. and Corvol,P.
    Inhibition of human renin by synthetic peptides derived from its prosegment
    J Biol Chem (5-8-1985) 260, 9154-9157. PubMed  Europe PubMed
  322. Szelke,M., Tree,M., Leckie,B.J., Jones,D.M., Atrash,B., Beattie,S., Donovan,B., Hallett,A., Hughes,M. and Lever,A.F.
    A transition-state analogue inhibitor of human renin (H.261): test in vitro and a comparison with captopril in the anaesthetized baboon
    J Hypertens (1985) 3, 13-18. PubMed  Europe PubMed DOI  I
  323. Webb,D.J., Manhem,P.J., Ball,S.G., Inglis,G., Leckie,B.J., Lever,A.F., Morton,J.J., Robertson,J.I., Murray,G.D. and Menard,J.
    A study of the renin inhibitor H142 in man
    J Hypertens (1985) 3, 653-658. PubMed  Europe PubMed  I
    324. 1984
  324. Chirgwin,J.M., Schaefer,I.M., Rotwein,P.S., Piccini,N., Gross,K.W. and Naylor,S.L.
    Human renin gene is on chromosome 1
    Somat Cell Mol Genet (1984) 10, 415-421. PubMed  Europe PubMed
  325. Haber,E.
    The first Sir George Pickering memorial lecture. Which inhibitors will give us true insight into what renin really does?
    J Hypertens (1984) 2, 223-230. PubMed  Europe PubMed  I
  326. Hardman,J.A., Hort,Y.J., Catanzaro,D.F., Tellam,J.T., Baxter,J.D., Morris,B.J. and Shine,J.
    Primary structure of the human renin gene
    DNA (1984) 3, 457-468. PubMed  Europe PubMed
  327. Miyazaki,H., Fukamizu,A., Hirose,S., Hayashi,T., Hori,H., Ohkubo,H., Nakanishi,S. and Murakami,K.
    Structure of the human renin gene
    Proc Natl Acad Sci U S A (1984) 81, 5999-6003. PubMed  Europe PubMed  PMC  EPMC
  328. Pandey,K.N., Melner,M.H., Parmentier,M. and Inagami,T.
    Demonstration of renin activity in purified rat Leydig cells: evidence for the existence of an endogenous inactive (latent) form of enzyme
    Endocrinology (1984) 115, 1753-1759. PubMed  Europe PubMed DOI
  329. [YEAR:1-8-1984]Poe,M., Wu,J.K., Lin,T.Y., Hoogsteen,K., Bull,H.G. and Slater,E.E.
    Renin cleavage of a human kidney renin substrate analogous to human angiotensinogen, H-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Ser-OH, that is human renin specific and is resistant to cathepsin D
    Anal Biochem (1-8-1984) 140, 459-467. PubMed  Europe PubMed  P
    330. 1983
  330. [YEAR:5-5-1983]Boger,J., Lohr,N.S., Ulm,E.H., Poe,M., Blaine,E.H., Fanelli,G.M., Lin,T.Y., Payne,L.S., Schorn,T.W., LaMont,B.I., Vassil,T.C., Stabilito,I.I., Veber,D.F., Rich,D.H. and Bopari,A.S.
    Novel renin inhibitors containing the amino acid statine
    Nature (5-5-1983) 303, 81-84. PubMed  Europe PubMed  I
  331. [YEAR:1-5-1983]McIntyre,G.D., Leckie,B., Hallett,A. and Szelke,M.
    Purification of human renin by affinity chromatography using a new peptide inhibitor of renin, H.77 (D-His-Pro-Phe-His-LeuR-Leu-Val-Tyr)
    Biochem J (1-5-1983) 211, 519-522. PubMed  Europe PubMed  PMC  EPMC  I
  332. Tree,M., Atrash,B., Donovan,B., Gamble,J., Hallett,A., Hughes,M., Jones,D.M., Leckie,B., Lever,A.F. and Morton,J.J.
    New inhibitors of human renin tested in vitro and in vivo in the anaesthetized baboon
    J Hypertens (1983) 1, 399-403. PubMed  Europe PubMed  I
  333. Webb,D.J., Cumming,A.M., Leckie,B.J., Lever,A.F., Morton,J.J., Robertson,J.I., Szelke,M. and Donovan,B.
    Reduction of blood pressure in man with H-142, a potent new renin inhibitor
    Lancet (1983) 2, 1486-1487. PubMed  Europe PubMed  I
    334. 1982
  334. Mullins,J.J., Burt,D.W., Windass,J.D., McTurk,P., George,H. and Brammar,W.J.
    Molecular cloning of two distinct renin genes from the DBA/2 mouse
    EMBO J (1982) 1, 1461-1466. PubMed  Europe PubMed  PMC  EPMC
  335. Ondetti,M.A. and Cushman,D.W.
    Enzymes of the renin-angiotensin system and their inhibitors
    Annu Rev Biochem (1982) 51, 283-308. PubMed  Europe PubMed DOI  V  I
  336. [YEAR:7-10-1982]Szelke,M., Leckie,B., Hallett,A., Jones,D.M., Sueiras,J., Atrash,B. and Lever,A.F.
    Potent new inhibitors of human renin
    Nature (7-10-1982) 299, 555-557. PubMed  Europe PubMed  I
  337. [YEAR:15-1-1982]Takii,Y. and Inagami,T.
    Purification of a completely inactive renin from hog kidney and identification as renin zymogen
    Biochem Biophys Res Commun (15-1-1982) 104, 133-140. PubMed  Europe PubMed
    338. 1981
  338. [YEAR:1-8-1981]Eid,M., Evin,G., Castro,B., Menard,J. and Corvol,P.
    New renin inhibitors homologous with pepstatin
    Biochem J (1-8-1981) 197, 465-471. PubMed  Europe PubMed  PMC  EPMC  I
  339. [YEAR:1-1-1981]Murakami,K., Ohsawa,T., Hirose,S., Takada,K. and Sakakibara,S.
    New fluorogenic substrates for renin
    Anal Biochem (1-1-1981) 110, 232-239. PubMed  Europe PubMed  A
  340. Slater,E.E.
    Renin
    Methods Enzymol (1981) 80, 427-442. PubMed  Europe PubMed DOI  V
  341. Slater,E.E. and Strout,H.V., Jr.
    Pure human renin. Identification and characterization of two major molecular weight forms
    J Biol Chem (1981) 256, 8164-8171. PubMed  Europe PubMed
    342. 1980
  342. [YEAR:17-11-1980]Cody,R.J., Burton,J., Evin,G., Poulsen,K., Herd,J.A. and Haber,E.
    A substrate analog inhibitor of renin that is effective in vivo
    Biochem Biophys Res Commun (17-11-1980) 97, 230-235. PubMed  Europe PubMed  I
  343. Conio,G., Ghiani,P., Patrone,E., Trefiletti,V., Uva,B. and Vallarino,M.
    Isolation and characterization of multiple forms of renin from bull kidney
    Biochim Biophys Acta (1980) 623, 317-328. PubMed  Europe PubMed
  344. Johnson,R.L. and Poisner,A.M.
    Inactivation of amniotic prorenin by ethyl diazoacetylglycinate
    Biochem Biophys Res Commun (1980) 95, 1404-1409. PubMed  Europe PubMed  I
    345. 1979
  345. [YEAR:10-6-1979]Galen,F.X., Devaux,C., Guyenne,T., Menard,J. and Corvol,P.
    Multiple forms of human renin. Purification and characterization
    J Biol Chem (10-6-1979) 254, 4848-4855. PubMed  Europe PubMed
  346. Marks,L.S. and Maxwell,M.H.
    Tigerstedt and the discovery of renin. An historical note
    Hypertension (1979) 1, 384-388. PubMed  Europe PubMed
  347. Poulsen,K., Vuust,J., Lykkegaard,S., Nielsen,A.H. and Lund,T.
    Renin is synthesized as a 50,000 dalton single-chain polypeptide in cell-free translation systems
    FEBS Lett (1979) 98, 135-138. PubMed  Europe PubMed
    348. 1978
  348. Evin,G., Gardes,J., Kreft,C., Castro,B., Corvol,P. and Menard,J.
    Soluble pepstatins: a new approach to blockade in vivo of the renin-angiotensin system
    Clin Sci Mol Med (1978) 55, 167s-169s.  I
  349. [YEAR:12-10-1978]Matoba,T., Murakami,K. and Inagami,T.
    Rat renin: purification and characterization
    Biochim Biophys Acta (12-10-1978) 526, 560-571. PubMed  Europe PubMed
  350. Miyazaki,M., Okunishi,H., Komori,T. and Yamamoto,K.
    Renin inhibitory effect of N-acetyl-pepstatin
    Jpn J Pharmacol (1978) 28, 171-174. PubMed  Europe PubMed  I
    351. 1977
  351. Corvol,P., Devaux,C., Ito,T., Sicard,P., Ducloux,J. and Menard,J.
    Large scale purification of hog renin. Physicochemical characterization
    Circ Res (1977) 41, 616-622. PubMed  Europe PubMed
  352. Inagami,T. and Murakami,K.
    Pure renin. Isolation from hog kidney and characterization
    J Biol Chem (1977) 252, 2978-2983. PubMed  Europe PubMed
  353. Inagami,T., Murakami,K., Misono,K., Workman,R.J., Cohen,S. and Suketa,Y.
    Renin and precursors: purification, characterization, and studies on active site
    Adv Exp Med Biol (1977) 95, 225-247. PubMed  Europe PubMed
    354. 1976
  354. Lentz,K.E., Skeggs,L.T., Dorer,F.E., Kahn,J.R. and Levine,M.
    A new radiolabeled protein renin substrate
    Anal Biochem (1976) 74, 1-11. PubMed  Europe PubMed DOI  A
  355. Swales,J.D., Amery,A., Lijnen,P., Fagard,R. and Reybrouck,T.
    Inactive renin in human plasma
    Lancet (1976) 308, 849-850. DOI
    356. 1975
  356. [YEAR:26-8-1975]Burton,J., Poulsen,K. and Haber,E.
    Competitive inhibitors of renin. Inhibitors effective at physiological pH
    Biochemistry (26-8-1975) 14, 3892-3898. PubMed  Europe PubMed  I
  357. [YEAR:1-1-1975]McKown,M.M. and Gregerman,R.I.
    Human renin inhibition by a diazoacyl reagent: relationship of the enzyme to other proteinases
    Life Sci (1-1-1975) 16, 71-79. PubMed  Europe PubMed
    358. 1974
  358. [YEAR:25-12-1974]McKown,M.M., Workman,R.J. and Gregerman,R.I.
    Pepstatin inhibition of human renin. Kinetic studies and estimation of enzyme purity
    J Biol Chem (25-12-1974) 249, 7770-7774. PubMed  Europe PubMed  I
    359. 1973
  359. [YEAR:15-10-1973]Parikh,I. and Cuatrecasas,P.
    Substrate analog competitive inhibitors of human renin
    Biochem Biophys Res Commun (15-10-1973) 54, 1356-1361. PubMed  Europe PubMed  I
  360. [YEAR:25-9-1973]Poulsen,K., Burton,J. and Haber,E.
    Competitive inhibitors of renin
    Biochemistry (25-9-1973) 12, 3877-3882. PubMed  Europe PubMed  I
    361. 1972
  361. Gross,F., Lazar,J. and Orth,H.
    Inhibition of the renin-angiotensinogen reaction by pepstatin
    Science (1972) 175, 656-656. PubMed  Europe PubMed  I
    362. 1970
  362. Smeby,R.R. and Bumpus,F.M.
    [51] Renin
    Methods Enzymol (1970) 19, 699-706. DOI
    363. 1969
  363. Reinharz,A. and Roth,M.
    Studies on renin with synthetic substrates
    Eur J Biochem (1969) 7, 334-339. PubMed  Europe PubMed
    364. 1968
  364. [YEAR:1-7-1968]Skeggs,L.T., Lentz,K.E., Kahn,J.R. and Hochstrasser,H.
    Kinetics of the reaction of renin with nine synthetic peptide substrates
    J Exp Med (1-7-1968) 128, 13-34. PubMed  Europe PubMed  PMC  EPMC  P  I
    365. 1965
  365. Arakawa,K., Nakatani,M. and Nakamura,M.
    Species specificity in reaction between renin and angiotensinogen
    Nature (1965) 207, 636-636. PubMed  Europe PubMed DOI
    366. 1964
  366. Mazur,R.H. and Schlatter,J.M.
    Synthesis of a renin substrate
    J Org Chem (1964) 29, 3212-3216.
    367. 1962
  367. Kemp,E. and Rubin,I.
    Renin purification by DEAE cellulose chromatography
    Scand J Clin Lab Invest (1962) 14, 207-211. PubMed  Europe PubMed
    368. 1942
  368. Schales,O.
    Preparation and properties of renin
    J Am Chem Soc (1942) 64, 561-564.
    369. 1941
  369. Wakerlin,G.E., Johnson,C.A., Gomberg,B. and Goldberg,M.L.
    Reduction in the blood pressures of renal hypertensive dogs with hog renin
    Science (1941) 93, 332-332. PubMed  Europe PubMed DOI
    370. 1940
  370. Braun-Menendez,E., Fasciolo,J.C., Leloir,L.F. and Munoz,J.M.
    The substance causing renal hypertension
    J Physiol (1940) 98, 283-298. PubMed  Europe PubMed  PMC  EPMC
  371. Page,I.H. and Helmer,O.M.
    A CRYSTALLINE PRESSOR SUBSTANCE (ANGIOTONIN) RESULTING FROM THE REACTION BETWEEN RENIN AND RENIN-ACTIVATOR
    J Exp Med (1940) 71, 29-42. PubMed  Europe PubMed  PMC  EPMC
    372. 1898
  372. Tigerstedt,R. and Bergmann,P.
    Niere und kreislauf
    Skand Arch Physiol (1898) 8, 223-271.
    373. 1890
  373. Lea,A.S. and Dickinson,W.L.
    Notes on the mode of action of rennin and fibrin-ferment
    J Physiol (1890) 11, 307-311. PubMed  Europe PubMed
    374. 1840
  374. Deschamps,J.B.
    [De la pressure]
    J Pharm Acc (1840) 26, 412-420.

feedback
Page created 8-September-2023

EMBL-EBI logo

© 2026 EBI
Terms of use