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Literature for peptidase C01.005: stem bromelain

Summary Alignment Sequences Sequence features Distribution Structure Literature Substrates

(References are filtered for relevance to Therapeutic. To remove the filter click here. See explanation.)

    2020
  1. Bakare,A.O. and Owoyele,B.V.
    Bromelain reversed electrolyte imbalance in the chronically constricted sciatic nerve of Wistar rats
    Naunyn Schmiedebergs Arch Pharmacol (2020) 393, 457-467. PubMed  Europe PubMed DOI  U
  2. Harats,M., Haik,J., Cleary,M., Vashurin,I., Aviv,U. and Kornhaber,R.
    A retrospective review of an off-label bromelain-based selective enzymatic debridement (Nexobrid(R)) in the treatment of deep, partial, and full thickness burns and hard to heal wounds
    Isr Med Assoc J (2020) 22, 83-88. PubMed  Europe PubMed  U
    3. 2019
  3. De Souza,G.M., Fernandes,I.A., Dos Santos,C.R.R. and Falci,S.G.M.
    Is bromelain effective in controlling the inflammatory parameters of pain, edema, and trismus after lower third molar surgery? A systematic review and meta-analysis
    Phytother Res (2019) 33, 473-481. PubMed  Europe PubMed DOI  U
  4. Ghensi,P., Cucchi,A., Bonaccorso,A., Ferroni,L., Gardin,C., Mortellaro,C. and Zavan,B.
    In vitro effect of bromelain on the regenerative properties of mesenchymal stem cells
    J Craniofac Surg (2019) 30, 1064-1067. PubMed  Europe PubMed DOI  U
  5. Lee,J.H., Lee,J.T., Park,H.R. and Kim,J.B.
    The potential use of bromelain as a natural oral medicine having anticarcinogenic activities
    Food Sci Nutr (2019) 7, 1656-1667. PubMed  Europe PubMed DOI  PMC  EPMC  U
  6. Mohamad,N.E., Abu,N., Yeap,S.K. and Alitheen,N.B.
    Bromelain enhances the anti-tumor effects of cisplatin on 4T1 breast tumor model in vivo
    Integr Cancer Ther (2019) 18, 1534735419880258-1534735419880258. PubMed  Europe PubMed DOI  U
  7. Raeisi,F., Raeisi,E., Heidarian,E., Shahbazi-Gahroui,D. and Lemoigne,Y.
    Bromelain inhibitory effect on colony formation: an in vitro study on human AGS, PC3, and MCF7 cancer cells
    J Med Signals Sens (2019) 9, 267-273. PubMed  Europe PubMed DOI  PMC  EPMC  U
    8. 2018
  8. Berner,J.E., Keckes,D., Pywell,M. and Dheansa,B.
    Limitations to the use of bromelain-based enzymatic debridement (NexoBrid((R))) for treating diabetic foot burns: a case series of disappointing results
    Scars Burn Heal (2018) 4, 2059513118816534-2059513118816534. PubMed  Europe PubMed DOI  PMC  EPMC  U
  9. Loo,Y.L., Goh,B.K.L. and Jeffery,S.
    An overview of the use of bromelain-based enzymatic debridement (Nexobrid(R)) in deep partial and full thickness burns: appraising the evidence
    J Burn Care Res (2018) 39, 932-938. PubMed  Europe PubMed DOI  U
  10. Park,S., Oh,J., Kim,M. and Jin,E.J.
    Bromelain effectively suppresses Kras-mutant colorectal cancer by stimulating ferroptosis
    Animal Cells Syst (Seoul) (2018) 22, 334-340. PubMed  Europe PubMed DOI  PMC  EPMC  U
  11. Shoham,Y., Krieger,Y., Tamir,E., Silberstein,E., Bogdanov-Berezovsky,A., Haik,J. and Rosenberg,L.
    Bromelain-based enzymatic debridement of chronic wounds: a preliminary report
    Int Wound J (2018) 15, 769-775. PubMed  Europe PubMed DOI  U
  12. Singer,A.J., Toussaint,J., Chung,W.T., McClain,S.A., Clark,R.A.F., Asculai,E., Geblinger,D. and Rosenberg,L.
    Development of a contaminated ischemic porcine wound model and the evaluation of bromelain based enzymatic debridement
    Burns (2018) 44, 896-904. PubMed  Europe PubMed DOI  U
  13. Soheilifar,S., Bidgoli,M., Hooshyarfard,A., Shahbazi,A., Vahdatinia,F. and Khoshkhooie,F.
    Effect of oral bromelain on wound healing, pain, and bleeding at donor site following free gingival grafting: a clinical trial
    J Dent (Tehran) (2018) 15, 309-316. PubMed  Europe PubMed  PMC  EPMC  U
    14. 2017
  14. Muhammad,Z.A. and Ahmad,T.
    Therapeutic uses of pineapple-extracted bromelain in surgical care - a review
    J Pak Med Assoc (2017) 67, 121-125. PubMed  Europe PubMed  V  U
  15. Oliveira,C.P., Prado,W.A., Lavayen,V., Buttenbender,S.L., Beckenkamp,A., Martins,B.S., Ludtke,D.S., Campo,L.F., Rodembusch,F.S., Buffon,A., Pessoa,A., Jr., Guterres,S.S. and Pohlmann,A.R.
    Bromelain-functionalized multiple-wall lipid-core nanocapsules: formulation, chemical structure and antiproliferative effect against human breast cancer cells (MCF-7)
    Pharm Res (2017) 34, 438-452. PubMed  Europe PubMed DOI  U
    16. 2016
  16. Belcher,M.D., Kaddour-Djebbar,I., Bollag,W.B. and Davis,L.S.
    The proteolytic effect of bromelain on bullous pemphigoid antigen-2
    J Am Acad Dermatol (2016) 75, 838-840. PubMed  Europe PubMed DOI  U
  17. Bernela,M., Ahuja,M. and Thakur,R.
    Enhancement of anti-inflammatory activity of bromelain by its encapsulation in katira gum nanoparticles
    Carbohydr Polym (2016) 143, 18-24. PubMed  Europe PubMed DOI  U
  18. Bhatnagar,P., Pant,A.B., Shukla,Y., Panda,A. and Gupta,K.C.
    Hyaluronic acid grafted PLGA copolymer nanoparticles enhance the targeted delivery of Bromelain in Ehrlich's Ascites Carcinoma
    Eur J Pharm Biopharm (2016) 105, 176-192. PubMed  Europe PubMed DOI  U
  19. Bormann,K.H., Weber,K., Kloppenburg,H., Staude,P., Koch,A., Meiser,P. and Gellrich,N.C.
    Perioperative bromelain therapy after wisdom teeth extraction - a randomized, placebo-controlled, double-blinded, three-armed, cross-over dose-finding study
    Phytother Res (2016) 30, 2012-2019. PubMed  Europe PubMed DOI  U
  20. DaSilva,F.R.P., Vasconcelos,A.C.C.G., Alves,E.H.P., DeOliveira Junior,P.V., DeOliveira,J.S. and Vasconcelos,D.F.P.
    Bromelain: a potential strategy for the adjuvant treatment of periodontitis
    Dent Hypotheses (2016) 7, 88-93. DOI  U
  21. Kasemsuk,T., Saengpetch,N., Sibmooh,N. and Unchern,S.
    Improved WOMAC score following 16-week treatment with bromelain for knee osteoarthritis
    Clin Rheumatol (2016) 35, 2531-2540. PubMed  Europe PubMed DOI  U
  22. Muller,A., Barat,S., Chen,X., Bui,K.C., Bozko,P., Malek,N.P. and Plentz,R.R.
    Comparative study of antitumor effects of bromelain and papain in human cholangiocarcinoma cell lines
    Int J Oncol (2016) 48, 2025-2034. PubMed  Europe PubMed DOI  U
  23. Pauzi,A.Z., Yeap,S.K., Abu,N., Lim,K.L., Omar,A.R., Aziz,S.A., Chow,A.L., Subramani,T., Tan,S.G. and Alitheen,N.B.
    Combination of cisplatin and bromelain exerts synergistic cytotoxic effects against breast cancer cell line MDA-MB-231 in vitro
    Chin Med (2016) 11, 46-46. PubMed  Europe PubMed DOI  PMC  EPMC  U
  24. Rathnavelu,V., Alitheen,N.B., Sohila,S., Kanagesan,S. and Ramesh,R.
    Potential role of bromelain in clinical and therapeutic applications
    Biomed Rep (2016) 5, 283-288. PubMed  Europe PubMed DOI  PMC  EPMC  U
  25. Rubin,G., Rinott,M., Wolovelsky,A., Rosenberg,L., Shoham,Y. and Rozen,N.
    A new bromelain-based enzyme for the release of Dupuytren's contracture: Dupuytren's enzymatic bromelain-based release
    Bone Joint Res (2016) 5, 175-177. PubMed  Europe PubMed DOI  U
  26. Singh,T., More,V., Fatima,U., Karpe,T., Aleem,M.A. and Prameela,J.
    Effect of proteolytic enzyme bromelain on pain and swelling after removal of third molars
    J Int Soc Prev Community Dent (2016) 6, S197-S197. PubMed  Europe PubMed DOI  PMC  EPMC  U
    27. 2015
  27. Rosenberg,L., Shoham,Y., Krieger,Y., Rubin,G., Sander,F., Koller,J., David,K., Egosi,D., Ahuja,R. and Singer,A.J.
    Minimally invasive burn care: a review of seven clinical studies of rapid and selective debridement using a bromelain-based debriding enzyme (Nexobrid(R))
    Ann Burns Fire Disasters (2015) 28, 264-274. PubMed  Europe PubMed  PMC  EPMC  U
  28. Sahbaz,A., Aynioglu,O., Isik,H., Ozmen,U., Cengil,O., Gun,B.D. and Gungorduk,K.
    Bromelain: a natural proteolytic for intra-abdominal adhesion prevention
    Int J Surg (2015) 14C, 7-11. PubMed  Europe PubMed DOI  U
    29. 2014
  29. Amini,A., Masoumi-Moghaddam,S., Ehteda,A. and Morris,D.L.
    Bromelain and N-acetylcysteine inhibit proliferation and survival of gastrointestinal cancer cells in vitro: significance of combination therapy
    J Exp Clin Cancer Res (2014) 33, 92-92. PubMed  Europe PubMed DOI  PMC  EPMC  U
  30. Pillai,K., Ehteda,A., Akhter,J., Chua,T.C. and Morris,D.L.
    Anticancer effect of bromelain with and without cisplatin or 5-FU on malignant peritoneal mesothelioma cells
    Anticancer Drugs (2014) 25, 150-160. PubMed  Europe PubMed DOI  U
  31. Romano,B., Fasolino,I., Pagano,E., Capasso,R., Pace,S., De Rosa,G., Milic,N., Orlando,P., Izzo,A.A. and Borrelli,F.
    The chemopreventive action of bromelain, from pineapple stem (Ananas comosus L.), on colon carcinogenesis is related to antiproliferative and proapoptotic effects
    Mol Nutr Food Res (2014) 58, 457-465. PubMed  Europe PubMed DOI  U
    32. 2013
  32. Amini,A., Ehteda,A., Masoumi Moghaddam,S., Akhter,J., llai,K. and rris,D.L.
    Cytotoxic effects of bromelain in human gastrointestinal carcinoma cell lines (MKN45, KATO-III, HT29-5F12, and HT29-5M21)
    Onco Targets Ther (2013) 6, 403-409. PubMed  Europe PubMed DOI  PMC  EPMC  U
  33. Muller,S., Marz,R., Schmolz,M., Drewelow,B., Eschmann,K. and Meiser,P.
    Placebo-controlled randomized clinical trial on the immunomodulating activities of low- and high-dose bromelain after oral administration - New evidence on the antiinflammatory mode of action of bromelain
    Phytother Res (2013) 27, 199-204. PubMed  Europe PubMed DOI  U
  34. Pillai,K., Akhter,J., Chua,T.C. and Morris,D.L.
    Anticancer property of bromelain with therapeutic potential in malignant peritoneal mesothelioma
    Cancer Invest (2013) 31, 241-250. PubMed  Europe PubMed DOI  U
  35. Secor,E.R., Jr., Szczepanek,S.M., Castater,C.A., Adami,A.J., Matson,A.P., Rafti,E.T., Guernsey,L., Natarajan,P., McNamara,J.T., Schramm,C.M., Thrall,R.S. and Silbart,L.K.
    Bromelain inhibits allergic sensitization and murine asthma via modulation of dendritic cells
    Evid Based Complement Alternat Med (2013) 2013, 702196-702196. PubMed  Europe PubMed DOI  PMC  EPMC  U
    36. 2012
  36. Dave,S., Kaur,N.J., Nanduri,R., Dkhar,H.K., Kumar,A. and Gupta,P.
    Inhibition of adipogenesis and induction of apoptosis and lipolysis by stem bromelain in 3T3-L1 adipocytes
    PLoS ONE (2012) 7, e30831-e30831. PubMed  Europe PubMed DOI  PMC  EPMC  U
  37. Dhandayuthapani,S., Perez,H.D., Paroulek,A., Chinnakkannu,P., Kandalam,U., Jaffe,M. and Rathinavelu,A.
    Bromelain-induced apoptosis in GI-101A breast cancer cells
    J Med Food (2012) 15, 344-349. PubMed  Europe PubMed DOI  U
  38. Foroncewicz,B., Mucha,K., Heidland,A., Ciszek,M., Imiela,J., Helle,F. and Paczek,L.
    Modulation of serum levels of sRAGE by bromelain in patients with chronic kidney disease: a pilot study
    Pol Arch Intern Med (2012) 122, 514-516. PubMed  Europe PubMed  U
  39. Lopez-Garcia,B., Hernandez,M. and Segundo,B.S.
    Bromelain, a cysteine protease from pineapple (Ananas comosus) stem, is an inhibitor of fungal plant pathogens
    Lett Appl Microbiol (2012) 55, 62-67. PubMed  Europe PubMed DOI  U
  40. Mahajan,S., Chandra,V., Dave,S., Nanduri,R. and Gupta,P.
    Stem bromelain-induced macrophage apoptosis and activation curtail Mycobacterium tuberculosis persistence
    J Infect Dis (2012) 206, 366-376. PubMed  Europe PubMed DOI  U
  41. Meiser,P.
    Bromelain in paediatrics
    Z Phytother (2012) 33, 210-214. DOI  U
  42. Rosenberg,L., Krieger,Y., Silberstein,E., Arnon,O., Sinelnikov,I.A., Bogdanov-Berezovsky,A. and Singer,A.J.
    Selectivity of a bromelain based enzymatic debridement agent: a porcine study
    Burns (2012) 38, 1035-1040. PubMed  Europe PubMed DOI  U
  43. Secor,E.R., Jr., Shah,S.J., Guernsey,L.A., Schramm,C.M. and Thrall,R.S.
    Bromelain limits airway inflammation in an ovalbumin-induced murine model of established asthma
    Altern Ther Health Med (2012) 18, 9-17. PubMed  Europe PubMed  U
  44. Wu,S.Y., Hu,W., Zhang,B., Liu,S., Wang,J.M. and Wang,A.M.
    Bromelain ameliorates the wound microenvironment and improves the healing of firearm wounds
    J Surg Res (2012) 176, 503-509. PubMed  Europe PubMed DOI  U
    45. 2011
  45. Johann,K., Eschmann,K. and Meiser,P.
    [No clinical evidence for an enhanced bleeding tendency due to perioperative treatment with bromelain]
    Sportverletz Sportschaden (2011) 25, 108-113. PubMed  Europe PubMed DOI  U
  46. Karlsen,M., Hovden,A.O., Vogelsang,P., Tysnes,B.B. and Appel,S.
    Bromelain treatment leads to maturation of monocyte-derived dendritic cells but cannot replace PGE2 in a cocktail of IL-1beta, IL-6, TNF-alpha and PGE2
    Scand J Immunol (2011) 74, 135-143. PubMed  Europe PubMed DOI  U
  47. Ley,C.M., Tsiami,A., Ni,Q. and Robinson,N.
    A review of the use of bromelain in cardiovascular diseases
    Zhong Xi Yi Jie He Xue Bao (2011) 9, 702-710. PubMed  Europe PubMed DOI  U
    48. 2010
  48. Chobotova,K., Vernallis,A.B. and Majid,F.A.
    Bromelain's activity and potential as an anti-cancer agent: current evidence and perspectives
    Cancer Lett (2010) 290, 148-156. PubMed  Europe PubMed DOI  U
  49. Singer,A.J., McClain,S.A., Taira,B.R., Rooney,J., Steinhauff,N. and Rosenberg,L.
    Rapid and selective enzymatic debridement of porcine comb burns with bromelain-derived Debrase: acute-phase preservation of noninjured tissue and zone of stasis
    J Burn Care Res (2010) 31, 304-309. PubMed  Europe PubMed DOI  U
    50. 2009
  50. Bhui,K., Prasad,S., George,J. and Shukla,Y.
    Bromelain inhibits COX-2 expression by blocking the activation of MAPK regulated NF-kappa B against skin tumor-initiation triggering mitochondrial death pathway
    Cancer Lett (2009) 282, 167-176. PubMed  Europe PubMed DOI  U
    51. 2006
  51. Orsini,R.A.
    Bromelain
    Plast Reconstr Surg (2006) 118, 1640-1644. PubMed  Europe PubMed DOI  U

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