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Literature for peptidase C01.046: falcipain-2

Summary Alignment Sequences Sequence features Distribution Structure Literature Substrates Pharma

(References are filtered for relevance to Inhibitor. To remove the filter click here. See explanation.)

    2024
  1. Di Chio,C., Starvaggi,J., Totaro,N., Previti,S., Natale,B., Cosconati,S., Bogacz,M., Schirmeister,T., Legac,J., Rosenthal,P.J., Zappala,M. and Ettari,R.
    Development of Novel Peptidyl Nitriles Targeting Rhodesain and Falcipain-2 for the Treatment of Sleeping Sickness and Malaria
    Int J Mol Sci25, PubMed  Europe PubMed DOI  I
  2. Madhav,H., Reddy,G.S., Rizvi,Z., Jameel,E., Patel,T.S., Rahman,A., Yadav,V., Fatima,S., Heyat,F., Pal,K., Minju-Op,A., Subbarao,N., Bhattacharjee,S., Dixit,B.C., Sijwali,P.S. and Hoda,N.
    Reinvestigation of diphenylmethylpiperazine analogues of pyrazine as new class of Plasmodial cysteine protease inhibitors for the treatment of malaria
    RSC Med Chem15, 1022-1037. PubMed  Europe PubMed DOI  I
    3. 2020
  3. Aratikatla,E.K., Kalamuddin,M., Malhotra,P., Mohmmed,A. and Bhattacharya,A.K.
    Enantioselective Synthesis of gamma-Phenyl-gamma-amino Vinyl Phosphonates and Sulfones and Their Application to the Synthesis of Novel Highly Potent Antimalarials
    ACS Omega5, 29025-29037. PubMed  Europe PubMed DOI  I
  4. Singh,A., Kalamuddin,M., Maqbool,M., Mohmmed,A., Malhotra,P. and Hoda,N.
    Quinoline carboxamide core moiety-based compounds inhibit P. falciparumfalcipain-2: Design, synthesis and antimalarial efficacy studies
    Bioorg Chem104514-104514. PubMed  Europe PubMed DOI  I
  5. Singh,V., Hada,R.S., Uddin,A., Aneja,B., Abid,M., Pandey,K.C. and Singh,S.
    Inhibition of hemoglobin degrading protease falcipain-2 as a mechanism for anti-malarial activity of triazole-amino acid hybrids
    Curr Top Med Chem20, 377-389. PubMed  Europe PubMed DOI  I
    6. 2019
  6. Alberca,L.N., Chuguransky,S.R., Alvarez,C.L., Talevi,A. and Salas-Sarduy,E.
    In silico guided drug repurposing: discovery of new competitive and non-competitive inhibitors of falcipain-2
    Front Chem7, 534-534. PubMed  Europe PubMed DOI  I
  7. Allangba,K.N.P.G., Keita,M., Kre N'Guessan,R., Megnassan,E., Frecer,V. and Miertus,S.
    Virtual design of novel Plasmodium falciparum cysteine protease falcipain-2 hybrid lactone-chalcone and isatin-chalcone inhibitors probing the S2 active site pocket
    J Enzyme Inhib Med Chem34, 547-561. PubMed  Europe PubMed DOI  I
  8. Cianni,L., Feldmann,C.W., Gilberg,E., Gutschow,M., Juliano,L., Leitao,A., Bajorath,J. and Montanari,C.A.
    Can cysteine protease cross-class inhibitors achieve selectivity?
    J Med Chem62, 10497-10525. PubMed  Europe PubMed DOI  I
  9. Hernandez Gonzalez,J.E., Hernandez Alvarez,L., Pascutti,P.G. and Leite,V.B.P.
    Prediction of noncompetitive inhibitor binding mode reveals promising site for allosteric modulation of falcipain-2
    J Phys Chem B123, 7327-7342. PubMed  Europe PubMed DOI  I
  10. Machin,J.M., Kantsadi,A.L. and Vakonakis,I.
    The complex of Plasmodium falciparum falcipain-2 protease with an (E)-chalcone-based inhibitor highlights a novel, small, molecule-binding site
    Malar J18, 388-388. PubMed  Europe PubMed DOI  I
  11. Rana,D., Kalamuddin,M., Sundriyal,S., Jaiswal,V., Sharma,G., Das Sarma,K., Sijwali,P.S., Mohmmed,A., Malhotra,P. and Mahindroo,N.
    Identification of antimalarial leads with dual falcipain-2 and falcipain-3 inhibitory activity
    Bioorg Med Chem115155-115155. PubMed  Europe PubMed DOI  I
  12. Stoye,A., Juillard,A., Tang,A.H., Legac,J., Gut,J., White,K.L., Charman,S.A., Rosenthal,P.J., Grau,G.E.R., Hunt,N.H. and Payne,R.J.
    Falcipain inhibitors based on the natural product gallinamide A are potent in vitro and in vivo antimalarials
    J Med Chem62, 5562-5578. PubMed  Europe PubMed DOI  I
    13. 2018
  13. Aggarwal,S., Paliwal,D., Kaushik,D., Gupta,G.K. and Kumar,A.
    Pyrazole Schiff base hybrids as anti-malarial agents: synthesis, in vitro screening and computational study
    Comb Chem High Throughput Screen21, 194-203. PubMed  Europe PubMed DOI  I
  14. Bekono,B.D., Ntie-Kang,F., Owono Owono,L.C. and Megnassan,E.
    Targeting cysteine proteases from Plasmodium falciparum: a general overview, rational drug design and computational approaches for drug discovery
    Curr Drug Targets19, 501-526. PubMed  Europe PubMed DOI  I
  15. Hernandez-Gonzalez,J.E., Salas-Sarduy,E., Hernandez Ramirez,L.F., Pascual,M.J., Alvarez,D.E., Pabon,A., Leite,V.B.P., Pascutti,P.G. and Valiente,P.A.
    Identification of (4-(9H-fluoren-9-yl) piperazin-1-yl) methanone derivatives as falcipain 2 inhibitors active against Plasmodium falciparum cultures
    Biochim Biophys Acta Gen Subj1862, 2911-2923. PubMed  Europe PubMed DOI  I
  16. Himangini, Pathak,D.P., Sharma,V. and Kumar,S.
    Designing novel inhibitors against falcipain-2 of Plasmodium falciparum
    Bioorg Med Chem Lett28, 1566-1569. PubMed  Europe PubMed DOI  I
  17. Nizi,E., Sferrazza,A., Fabbrini,D., Nardi,V., Andreini,M., Graziani,R., Gennari,N., Bresciani,A., Paonessa,G. and Harper,S.
    Peptidomimetic nitrile inhibitors of malarial protease falcipain-2 with high selectivity against human cathepsins
    Bioorg Med Chem Lett28, 1540-1544. PubMed  Europe PubMed DOI  I
  18. Royo,S., Schirmeister,T., Kaiser,M., Jung,S., Rodriguez,S., Bautista,J.M. and Gonzalez,F.V.
    Antiprotozoal and cysteine proteases inhibitory activity of dipeptidyl enoates
    Bioorg Med Chem26, 4624-4634. PubMed  Europe PubMed DOI  I
  19. Salawu,E.O.
    In silico study reveals how E64 approaches, binds to, and inhibits falcipain-2 of Plasmodium falciparum that causes malaria in humans
    Sci Rep8, 16380-16380. PubMed  Europe PubMed DOI  I
    20. 2017
  20. Chen,W., Huang,Z., Wang,W., Mao,F., Guan,L., Tang,Y., Jiang,H., Li,J., Huang,J., Jiang,L. and Zhu,J.
    Discovery of new antimalarial agents: second-generation dual inhibitors against FP-2 and PfDHFR via fragments assembely
    Bioorg Med Chem25, 6467-6478. PubMed  Europe PubMed DOI  I
  21. Hernandez Gonzalez,J.E., Hernandez Alvarez,L., Pascutti,P.G. and Valiente,P.A.
    Predicting binding modes of reversible peptide-based inhibitors of falcipain-2 consistent with structure-activity relationships
    Proteins85, 1666-1683. PubMed  Europe PubMed DOI  I
  22. Previti,S., Ettari,R., Cosconati,S., Amendola,G., Chouchene,K., Wagner,A., Hellmich,U.A., Ulrich,K., Krauth-Siegel,R.L., Wich,P.R., Schmid,I., Schirmeister,T., Gut,J., Rosenthal,P.J., Grasso,S. and Zappala,M.
    Development of novel peptide-based Michael acceptors targeting rhodesain and falcipain-2 for the treatment of neglected tropical diseases (NTDs)
    J Med Chem60, 6911-6923. PubMed  Europe PubMed DOI  I
  23. Rudrapal,M., Chetia,D. and Singh,V.
    Novel series of 1,2,4-trioxane derivatives as antimalarial agents
    J Enzyme Inhib Med Chem32, 1159-1173. PubMed  Europe PubMed DOI  I
    24. 2016
  24. Musyoka,T.M., Kanzi,A.M., Lobb,K.A. and Tastan Bishop,O.
    Structure based docking and molecular dynamic studies of plasmodial cysteine proteases against a South African natural compound and its analogs
    Sci Rep6, 23690-23690. PubMed  Europe PubMed DOI  I
  25. Musyoka,T.M., Kanzi,A.M., Lobb,K.A. and Tastan Bishop,O.
    Analysis of non-peptidic compounds as potential malarial inhibitors against plasmodial cysteine proteases via integrated virtual screening workflow
    J Biomol Struct Dyn34, 2084-2101. PubMed  Europe PubMed DOI  I
  26. Poongavanam,V. and Kongsted,J.
    Binding affinity models for falcipain inhibition based on the linear interaction energy method
    J Mol Graph Model70, 236-245. PubMed  Europe PubMed DOI  I
  27. Schmidt,I., Pradel,G., Sologub,L., Golzmann,A., Ngwa,C.J., Kucharski,A., Schirmeister,T. and Holzgrabe,U.
    Bistacrine derivatives as new potent antimalarials
    Bioorg Med Chem24, 3636-3642. PubMed  Europe PubMed DOI  I
  28. Thillainayagam,M., Anbarasu,A. and Ramaiah,S.
    Comparative molecular field analysis and molecular docking studies on novel aryl chalcone derivatives against an important drug target cysteine protease in Plasmodium falciparum
    J Theor Biol403, 110-128. PubMed  Europe PubMed DOI  I
    29. 2015
  29. Bertoldo,J.B., Chiaradia-Delatorre,L.D., Mascarello,A., Leal,P.C., Cordeiro,M.N., Nunes,R.J., Sarduy,E.S., Rosenthal,P.J. and Terenzi,H.
    Synthetic compounds from an in house library as inhibitors of falcipain-2 from Plasmodium falciparum
    J Enzyme Inhib Med Chem30, 299-307. PubMed  Europe PubMed DOI  I
  30. Chakka,S.K., Kalamuddin,M., Sundararaman,S., Wei,L., Mundra,S., Mahesh,R., Malhotra,P., Mohmmed,A. and Kotra,L.P.
    Identification of novel class of falcipain-2 inhibitors as potential antimalarial agents
    Bioorg Med Chem23, 2221-2240. PubMed  Europe PubMed DOI  I
  31. Sharma,R.K., Younis,Y., Mugumbate,G., Njoroge,M., Gut,J., Rosenthal,P.J. and Chibale,K.
    Synthesis and structure-activity-relationship studies of thiazolidinediones as antiplasmodial inhibitors of the Plasmodium falciparum cysteine protease falcipain-2
    Eur J Med Chem90C, 507-518. PubMed  Europe PubMed DOI  I
  32. Singh,A.K., Rajendran,V., Pant,A., Ghosh,P.C., Singh,N., Latha,N., Garg,S., Pandey,K.C., Singh,B.K. and Rathi,B.
    Design, synthesis and biological evaluation of functionalized phthalimides: a new class of antimalarials and inhibitors of falcipain-2, a major hemoglobinase of malaria parasite
    Bioorg Med Chem23, 1817-1827. PubMed  Europe PubMed DOI  I
    33. 2014
  33. Arafet,K., Ferrer,S., Marti,S. and Moliner,V.
    Quantum mechanics/molecular mechanics studies of the mechanism of falcipain-2 inhibition by the epoxysuccinate E64
    Biochemistry53, 3336-3346. PubMed  Europe PubMed DOI  I
  34. Conroy,T., Guo,J.T., Elias,N., Cergol,K.M., Gut,J., Legac,J., Khatoon,L., Liu,Y., McGowan,S., Rosenthal,P.J., Hunt,N.H. and Payne,R.J.
    Synthesis of gallinamide A analogues as potent falcipain inhibitors and antimalarials
    J Med Chem57, 10557-10563. PubMed  Europe PubMed DOI  I
  35. Ettari,R., Pinto,A., Tamborini,L., Angelo,I.C., Grasso,S., Zappala,M., Capodicasa,N., Yzeiraj,L., Gruber,E., Aminake,M.N., Pradel,G., Schirmeister,T., De Micheli,C. and Conti,P.
    Synthesis and biological evaluation of papain-family cathepsin L-like cysteine protease inhibitors containing a 1,4-benzodiazepine scaffold as antiprotozoal agents
    ChemMedChem9, 1817-1825. PubMed  Europe PubMed DOI  I
  36. Jin,H., Xu,Z., Cui,K., Zhang,T., Lu,W. and Huang,J.
    Dietary flavonoids fisetin and myricetin: dual inhibitors of Plasmodium falciparum falcipain-2 and plasmepsin II
    Fitoterapia94, 55-61. PubMed  Europe PubMed DOI  I
  37. Omotuyi,O.I.
    Methyl-methoxylpyrrolinone and flavinium nucleus binding signatures on falcipain-2 active site
    J Mol Model20, 2386-2386. PubMed  Europe PubMed DOI  I
  38. Wang,L., Zhang,S., Zhu,J., Zhu,L., Liu,X., Shan,L., Huang,J., Zhang,W. and Li,H.
    Identification of diverse natural products as falcipain-2 inhibitors through structure-based virtual screening
    Bioorg Med Chem Lett24, 1261-1264. PubMed  Europe PubMed DOI  I
  39. Weldon,D.J., Shah,F., Chittiboyina,A.G., Sheri,A., Chada,R.R., Gut,J., Rosenthal,P.J., Shivakumar,D., Sherman,W., Desai,P., Jung,J.C. and Avery,M.A.
    Synthesis, biological evaluation, hydration site thermodynamics, and chemical reactivity analysis of alpha-keto substituted peptidomimetics for the inhibition of Plasmodium falciparum
    Bioorg Med Chem Lett24, 1274-1279. PubMed  Europe PubMed DOI  I
    40. 2013
  40. Mane,U.R., Gupta,R.C., Nadkarni,S.S., Giridhar,R.R., Naik,P.P. and Yadav,M.R.
    Falcipain inhibitors as potential therapeutics for resistant strains of malaria: a patent review
    Expert Opin Ther Pat23, 165-187. PubMed  Europe PubMed DOI  V  I
  41. Marques,A.F., Esser,D., Rosenthal,P.J., Kassack,M.U. and Lima,L.M.
    Falcipain-2 inhibition by suramin and suramin analogues
    Bioorg Med Chem21, 3667-3673. PubMed  Europe PubMed DOI  I
  42. Mugumbate,G., Newton,A.S., Rosenthal,P.J., Gut,J., Moreira,R., Chibale,K. and Guedes,R.C.
    Novel anti-Plasmodial hits identified by virtual screening of the ZINC database
    J Comput Aided Mol Des27, 859-871. PubMed  Europe PubMed DOI  I
  43. Somanadhan,B., Kotturi,S.R., Yan Leong,C., Glover,R.P., Huang,Y., Flotow,H., Buss,A.D., Lear,M.J. and Butler,M.S.
    Isolation and synthesis of falcitidin, a novel myxobacterial-derived acyltetrapeptide with activity against the malaria target falcipain-2
    J Antibiot (Tokyo)66, 259-264. PubMed  Europe PubMed DOI  I
  44. Tadigoppula,N., Korthikunta,V., Gupta,S., Kancharla,P., Khaliq,T., Soni,A., Srivastava,R.K., Srivastava,K., Puri,S.K., Raju,K.S., Wahajuddin, Sijwali,P.S., Kumar,V. and Mohammad,I.S.
    Synthesis and insight into the structure-activity relationships of chalcones as antimalarial agents
    J Med Chem56, 31-45. PubMed  Europe PubMed DOI  I
  45. Wang,J., Li,Y., Yang,Y., Zhang,S. and Yang,L.
    Profiling the structural determinants of heteroarylnitrile scaffold-based derivatives as falcipain-2 inhibitors by in silico methods
    Curr Med Chem20, 2032-2042. PubMed  Europe PubMed  I
    46. 2012
  46. Ettari,R., Micale,N., Grazioso,G., Bova,F., Schirmeister,T., Grasso,S. and Zappala,M.
    Synthesis and molecular modeling studies of derivatives of a highly potent peptidomimetic vinyl ester as falcipain-2 inhibitors
    ChemMedChem7, 1594-1600. PubMed  Europe PubMed DOI  I
  47. Grazioso,G., Legnani,L., Toma,L., Ettari,R., Micale,N. and De Micheli,C.
    Mechanism of falcipain-2 inhibition by alpha,beta-unsaturated benzo[1,4]diazepin-2-one methyl ester
    J Comput Aided Mol Des26, 1035-1043. PubMed  Europe PubMed DOI  I
  48. Huang,H., Lu,W., Li,X., Cong,X., Ma,H., Liu,X., Zhang,Y., Che,P., Ma,R., Li,H., Shen,X., Jiang,H., Huang,J. and Zhu,J.
    Design and synthesis of small molecular dual inhibitor of falcipain-2 and dihydrofolate reductase as antimalarial agent
    Bioorg Med Chem Lett22, 958-962. PubMed  Europe PubMed DOI  I
  49. Liu,Y., Lu,W.Q., Cui,K.Q., Luo,W., Wang,J. and Guo,C.
    Synthesis and biological activities of novel artemisinin derivatives as cysteine protease falcipain-2 inhibitors
    Arch Pharm Res35, 1525-1531. PubMed  Europe PubMed DOI  I
  50. Mane,U.R., Li,H., Huang,J., Gupta,R.C., Nadkarni,S.S., Giridhar,R., Naik,P.P. and Yadav,M.R.
    Pyrido[1,2-a]pyrimidin-4-ones as antiplasmodial falcipain-2 inhibitors
    Bioorg Med Chem20, 6296-6304. PubMed  Europe PubMed DOI  I
  51. Marco,M. and Coteron,J.M.
    Falcipain inhibition as a promising antimalarial target
    Curr Top Med Chem12, 408-444. PubMed  Europe PubMed DOI  I
  52. Pandey,K.C. and Dixit,R.
    Structure-function of falcipains: malarial cysteine proteases
    J Trop Med2012, 345195-345195. PubMed  Europe PubMed DOI  I
  53. Perez,B.C., Teixeira,C., Figueiras,M., Gut,J., Rosenthal,P.J., Gomes,J.R. and Gomes,P.
    Novel cinnamic acid/4-aminoquinoline conjugates bearing non-proteinogenic amino acids: towards the development of potential dual action antimalarials
    Eur J Med Chem54, 887-899. PubMed  Europe PubMed DOI  I
  54. Shah,F., Gut,J., Legac,J., Shivakumar,D., Sherman,W., Rosenthal,P.J. and Avery,M.A.
    Computer-aided drug design of falcipain inhibitors: virtual screening, structure-activity relationships, hydration site thermodynamics, and reactivity analysis
    J Chem Inf Model52, 696-710. PubMed  Europe PubMed DOI  I
  55. Stolze,S.C., Deu,E., Kaschani,F., Li,N., Florea,B.I., Richau,K.H., Colby,T., Van Der Hoorn,R.A., Overkleeft,H.S., Bogyo,M. and Kaiser,M.
    The antimalarial natural product symplostatin 4 is a nanomolar inhibitor of the food vacuole falcipains
    Chem Biol19, 1546-1555. PubMed  Europe PubMed DOI  I
    56. 2011
  56. Ehmke,V., Heindl,C., Rottmann,M., Freymond,C., Schweizer,W.B., Brun,R., Stich,A., Schirmeister,T. and Diederich,F.
    Potent and selective inhibition of cysteine proteases from Plasmodium falciparum and Trypanosoma brucei
    ChemMedChem6, 273-278. PubMed  Europe PubMed DOI  I
  57. Ehmke,V., Kilchmann,F., Heindl,C., Cui,K., Huang,J., Schirmeister,T. and Diederich,F.
    Peptidomimetic nitriles as selective inhibitors for the malarial cysteine protease falcipain-2
    MedChemComm2, 800-804. DOI  I
  58. Ettari,R., Zappala,M., Micale,N., Grazioso,G., Giofre,S., Schirmeister,T. and Grasso,S.
    Peptidomimetics containing a vinyl ketone warhead as falcipain-2 inhibitors
    Eur J Med Chem46, 2058-2065. PubMed  Europe PubMed DOI  I
  59. Liu,Y., Cui,K., Lu,W., Luo,W., Wang,J., Huang,J. and Guo,C.
    Synthesis and antimalarial activity of novel dihydro-artemisinin derivatives
    Molecules16, 4527-4538. PubMed  Europe PubMed DOI  I
  60. Micale,N., Cinellu,M.A., Maiore,L., Sannella,A.R., Severini,C., Schirmeister,T., Gabbiani,C. and Messori,L.
    Selected gold compounds cause pronounced inhibition of falcipain 2 and effectively block P. falciparum growth in vitro
    J Inorg Biochem105, 1576-1579. PubMed  Europe PubMed DOI  I
  61. Rizzi,L., Sundararaman,S., Cendic,K., Vaiana,N., Korde,R., Sinha,D., Mohmmed,A., Malhotra,P. and Romeo,S.
    Design and synthesis of protein-protein interaction mimics as Plasmodium falciparum cysteine protease, falcipain-2 inhibitors
    Eur J Med Chem46, 2083-2090. PubMed  Europe PubMed DOI  I
  62. Shah,F., Mukherjee,P., Gut,J., Legac,J., Rosenthal,P.J., Tekwani,B.L. and Avery,M.A.
    Identification of novel malarial cysteine protease inhibitors using structure-based virtual screening of a focused cysteine protease inhibitor library
    J Chem Inf Model51, 852-864. PubMed  Europe PubMed DOI  I
  63. Teixeira,C., Gomes,J.R.B., Couesnon,T. and Gomes,P.
    Molecular docking and 3D-quantitative structure activity relationship analyses of peptidyl vinyl sulfones: Plasmodium falciparum cysteine proteases inhibitors
    J Comput Aided Mol Des25, 763-775. PubMed  Europe PubMed DOI  I
    64. 2010
  64. Bova,F., Ettari,R., Micale,N., Carnovale,C., Schirmeister,T., Gelhaus,C., Leippe,M., Grasso,S. and Zappala,M.
    Constrained peptidomimetics as antiplasmodial falcipain-2 inhibitors
    Bioorg Med Chem18, 4928-4938. PubMed  Europe PubMed DOI  I
  65. Breuning,A., Degel,B., Schulz,F., Buchold,C., Stempka,M., Machon,U., Heppner,S., Gelhaus,C., Leippe,M., Leyh,M., Kisker,C., Rath,J., Stich,A., Gut,J., Rosenthal,P.J., Schmuck,C. and Schirmeister,T.
    Michael acceptor based antiplasmodial and antitrypanosomal cysteine protease inhibitors with unusual amino acids
    J Med Chem53, 1951-1963. PubMed  Europe PubMed DOI  I
  66. Coteron,J.M., Catterick,D., Castro,J., Chaparro,M.J., Diaz,B., Fernandez,E., Ferrer,S., Gamo,F.J., Gordo,M., Gut,J., de Las Heras,L., Legac,J., Marco,M., Miguel,J., Munoz,V., Porras,E., de la Rosa,J.C., Ruiz,J.R., Sandoval,E., Ventosa,P., Rosenthal,P.J. and Fiandor,J.M.
    Falcipain inhibitors: optimization studies of the 2-pyrimidinecarbonitrile lead series
    J Med Chem53, 6129-6152. PubMed  Europe PubMed DOI  I
  67. Ettari,R., Zappala,M., Micale,N., Schirmeister,T., Gelhaus,C., Leippe,M., Evers,A. and Grasso,S.
    Synthesis of novel peptidomimetics as inhibitors of protozoan cysteine proteases falcipain-2 and rhodesain
    Eur J Med Chem45, 3228-3233. PubMed  Europe PubMed DOI  I
  68. Ettari,R., Bova,F., Zappala,M., Grasso,S. and Micale,N.
    Falcipain-2 inhibitors
    Med Res Rev30, 136-167. PubMed  Europe PubMed DOI  V  I
  69. Gibbons,P., Verissimo,E., Araujo,N.C., Barton,V., Nixon,G.L., Amewu,R.K., Chadwick,J., Stocks,P.A., Biagini,G.A., Srivastava,A., Rosenthal,P.J., Gut,J., Guedes,R.C., Moreira,R., Sharma,R., Berry,N., Cristiano,M.L., Shone,A.E., Ward,S.A. and O'Neill,P.M.
    Endoperoxide carbonyl falcipain 2/3 inhibitor hybrids: toward combination chemotherapy of malaria through a single chemical entity
    J Med Chem53, 8202-8206. PubMed  Europe PubMed DOI  I
  70. Hans,R.H., Gut,J., Rosenthal,P.J. and Chibale,K.
    Comparison of the antiplasmodial and falcipain-2 inhibitory activity of beta-amino alcohol thiolactone-chalcone and isatin-chalcone hybrids
    Bioorg Med Chem Lett20, 2234-2237. PubMed  Europe PubMed DOI  I
  71. Khanye,S.D., Smith,G.S., Lategan,C., Smith,P.J., Gut,J., Rosenthal,P.J. and Chibale,K.
    Synthesis and in vitro evaluation of gold(I) thiosemicarbazone complexes for antimalarial activity
    J Inorg Biochem104, 1079-1083. PubMed  Europe PubMed DOI  I
  72. Loser,R., Gut,J., Rosenthal,P.J., Frizler,M., Gutschow,M. and Andrews,K.T.
    Antimalarial activity of azadipeptide nitriles
    Bioorg Med Chem Lett20, 252-255. PubMed  Europe PubMed DOI  I
  73. Waag,T., Gelhaus,C., Rath,J., Stich,A., Leippe,M. and Schirmeister,T.
    Allicin and derivates are cysteine protease inhibitors with antiparasitic activity
    Bioorg Med Chem Lett20, 5541-5543. PubMed  Europe PubMed DOI  I
    74. 2009
  74. Dude,M.A., Kaeppler,U., Herb,M., Schiller,M., Schulz,F., Vedder,B., Heppner,S., Pradel,G., Gut,J., Rosenthal,P.J., Schirmeister,T., Leippe,M. and Gelhaus,C.
    Synthesis and evaluation of non-peptidic cysteine protease inhibitors of P. falciparum derived from etacrynic acid
    Molecules14, 19-35. PubMed  Europe PubMed DOI  I
  75. Kerr,I.D., Lee,J.H., Pandey,K.C., Harrison,A., Sajid,M., Rosenthal,P.J. and Brinen,L.S.
    Structures of falcipain-2 and falcipain-3 bound to small molecule inhibitors: implications for substrate specificity
    J Med Chem52, 852-857. PubMed  Europe PubMed DOI  S  I
  76. Micale,N., Ettari,R., Schirmeister,T., Evers,A., Gelhaus,C., Leippe,M., Zappala,M. and Grasso,S.
    Novel 2H-isoquinolin-3-ones as antiplasmodial falcipain-2 inhibitors
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  77. Zhu,J., Chen,T., Liu,J., Ma,R., Lu,W., Huang,J., Li,H., Li,J. and Jiang,H.
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