$VAR1 = undef;
Summary for peptidase T03.006: gamma-glutamyltransferase 1 (mammalian-type)
| Names | |
|---|---|
| MEROPS Name | gamma-glutamyltransferase 1 (mammalian-type) |
| Other names | GGT1 g.p. (Homo sapiens), gamma-glutamyl leukotrienase |
| Domain architecture |
|---|
| MEROPS Classification | |
|---|---|
| Classification | Clan PB >> Subclan PB(T) >> Family T3 >> Subfamily (none) >> T03.006 |
| Holotype | gamma-glutamyltransferase 1 (mammalian-type) (Homo sapiens), Uniprot accession P19440 (peptidase unit: 18-569), MERNUM MER0001629 |
| History | Identifier created: MEROPS 5.3 (4 December 2000) |
| Activity | |||
|---|---|---|---|
| Catalytic type | Threonine | ||
| NC-IUBMB | 2.3.2.2; E | ||
| Enzymology | BRENDA database | ||
| Activity status | human: active (Hiratake et al., 2004) mouse: active (<%DeBault & Cancilla, 1980[20040831A1050]%>) | ||
| Knockout | Knockout mice display chronic glutathione deficiency and growth retardation, and die at about 20 weeks (Will et al., 2000). They also show some immunological abnormality (Lawrence et al., 2000). | ||
| Pathways | KEGG | Cyanoamino acid metabolism | |
| KEGG | Glutathione metabolism | ||
| KEGG | Taurine and hypotaurine metabolism | ||
| Other databases | TREEFAM | http://www.treefam.org/family/TF313608 | |
| Human genetics | ||||||
|---|---|---|---|---|---|---|
| Gene symbol | Locus | Megabases | Ensembl | Entrez gene | Gene Cards | OMIM |
| GGT1 | 22q11.23 | ENSG00000100031 | 2678 | GGT1 | 231950 | |
