$VAR1 = undef;

Summary for peptidase T01.014: proteasome subunit beta2i

Names
MEROPS Name	proteasome subunit beta2i
Other names	immunoproteasome catalytic subunit 2, immunoproteasome catalytic subunit beta2i, LMP10 (Homo sapiens), MECL1 (Homo sapiens), proteasome subunit beta 7i, proteasome subunit beta 10, PSMB10 g.p. (Homo sapiens, Mus musculus), multicatalytic endopeptidase complex like 1

Domain architecture

MEROPS Classification
Classification	Clan PB >> Subclan PB(T) >> Family T1 >> Subfamily A >> T01.014
Holotype	proteasome subunit beta2i (Homo sapiens), Uniprot accession P40306 (peptidase unit: 40-230), MERNUM MER0001515
History	Identifier created: MEROPS 3.02 (25 June 1998)

Activity
Catalytic type	Threonine
NC-IUBMB	Subclass 3.4 (Peptidases) >> Sub-subclass 3.4.25 (Threonine-type endopeptidases) >> Peptidase 3.4.25.1
Enzymology	BRENDA database
Activity status	human: active (Seemuller et al., 2004) mouse: putative
Physiology	One of the peptidase units of the 20 S proteasome that is preferentially expressed upon stimulation of the immune system, and then partially replaces subunit 2 in the multipeptidase complex. May be particularly effective in the generation of antigenic peptides for the MHC class II system.
Pharmaceutical relevance	Proteasome inhibitors exhibit anti-inflammatory and antiproliferative effects, and it is threrefore considered that inhibitors have the potential to be drugs for conditions such as cancer, rhuematoid arthritis and psoriasis that are characterised by these processes (Delcros et al., 2003; Elliott et al., 2003).
Pathways	KEGG	Proteasome
Other databases	TREEFAM	http://www.treefam.org/family/TF106222