Summary for peptidase S28.003: thymus-specific serine peptidase

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Literature


MEROPS Namethymus-specific serine peptidase
Other namesMername-AA266 peptidase, TSSP, PRSS16 g.p. (Homo sapiens)
Domain architecture
MEROPS Classification
Classification Clan SC >> Subclan (none) >> Family S28 >> Subfamily (none) >> S28.003
Holotypethymus-specific serine peptidase (Mus musculus), Uniprot accession Q9QXE5 (peptidase unit: 54-509), MERNUM MER0006066
History Identifier created: MEROPS 3.4 (5 November 1999)
Catalytic typeSerine
NC-IUBMBNot yet included in IUBMB recommendations.
Activity statushuman: putative
mouse: putative
PhysiologyThymus-specific serine peptidase is a serine peptidase that is reported to be expressed exclusively in cortical thymic epithelial cells of the thymus (Cheunsuk et al., 2005).
KnockoutMice deficient in thymus-specific serine peptidase develop normally, are fertile, and show normal thymic morphology, cellularity, and anatomy (Cheunsuk et al., 2005).
Other databases TREEFAM
Human genetics
Gene symbol Locus Megabases Ensembl Entrez gene Gene Cards OMIM
PRSS16 6p21.31-p22.2 ENSG00000112812 10279 PRSS16 607169
Mouse genetics
Gene symbol Position Megabases Ensembl Entrez gene MGI
Prss16 13 ENSMUSG00000006179 54373 MGI:1859181