Summary for peptidase S28.003: thymus-specific serine peptidase

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Literature

 

Names
MEROPS Namethymus-specific serine peptidase
Other namesMername-AA266 peptidase, TSSP, PRSS16 g.p. (Homo sapiens)
Domain architecture
MEROPS Classification
Classification Clan SC >> Subclan (none) >> Family S28 >> Subfamily (none) >> S28.003
Holotypethymus-specific serine peptidase (Mus musculus), Uniprot accession Q9QXE5 (peptidase unit: 54-509), MERNUM MER0006066
History Identifier created: MEROPS 3.4 (5 November 1999)
Activity
Catalytic typeSerine
NC-IUBMBNot yet included in IUBMB recommendations.
Activity statushuman: putative
mouse: putative
PhysiologyThymus-specific serine peptidase is a serine peptidase that is reported to be expressed exclusively in cortical thymic epithelial cells of the thymus (Cheunsuk et al., 2005).
KnockoutMice deficient in thymus-specific serine peptidase develop normally, are fertile, and show normal thymic morphology, cellularity, and anatomy (Cheunsuk et al., 2005).
Other databases TREEFAMhttp://www.treefam.org/family/TF314855
PANTHERhttp://www.pantherdb.org/panther/familyList.do?searchType=basic&fieldName=all&listType=6&fieldValue=PTHR11010:SF22
Human genetics
Gene symbol Locus Megabases Ensembl Entrez gene Gene Cards OMIM
PRSS16 6p21.31-p22.2 ENSG00000112812 10279 PRSS16 607169
Mouse genetics
Gene symbol Position Megabases Ensembl Entrez gene MGI
Prss16 13 ENSMUSG00000006179 54373 MGI:1859181