$VAR1 = undef;
Summary for peptidase S21.003: Epstein-Barr virus-type assemblin
| Names | |
|---|---|
| MEROPS Name | Epstein-Barr virus-type assemblin |
| Domain architecture |
|---|
| MEROPS Classification | |
|---|---|
| Classification | Clan SH >> Subclan (none) >> Family S21 >> Subfamily (none) >> S21.003 |
| Holotype | Epstein-Barr virus-type assemblin (human herpesvirus 4), Uniprot accession P03234 (peptidase unit: 1-235), MERNUM MER0000612 |
| History | Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London. |
| Activity | |||
|---|---|---|---|
| Catalytic type | Serine | ||
| NC-IUBMB | Not yet included in IUBMB recommendations. | ||
| Physiology | Plays essential role in assembly of Epstein-Barr virus virions by digesting scaffold protein. | ||
| Pharmaceutical relevance | Potential target for antiviral drug. Epstein-Barr virus is the cause of a latent, asymptomatic infection in a large percentage of the population, but in young adults primary infection can result in infectious mononucleosis (glandular fever). Proteins expressed in the later, latent phase of the viral life cycle have been associated with a number of diseases including Burkitt’s lymphoma, nasopharyngeal carcinoma and Hodgkin’s disease. | ||
