$VAR1 = undef;

Summary for peptidase S01.281: arginyl peptidase

Names
MEROPS Name	arginyl peptidase
Other names	endoproteinase Arg-C, protease IV (Pseudomonas aeruginosa), prpL endoprotease (Pseudomonas aeruginosa)

Domain architecture

MEROPS Classification
Classification	Clan PA >> Subclan PA(S) >> Family S1 >> Subfamily E >> S01.281
Holotype	arginyl peptidase (Lysobacter enzymogenes) (peptidase unit: 259-455), MERNUM MER0005081
History	Identifier created: MEROPS 3.30 (20 July 1999)

Activity
Catalytic type	Serine
NC-IUBMB	Not yet included in IUBMB recommendations.
Knockout	A strain of Pseudomonas aeruginosa specifically deficient in arginyl endopeptidase (as protease IV) had reduced corneal virulence (Caballero et al., 2004).
Pharmaceutical relevance	Proposed to be a virulence factor in corneal infection by Pseudomonas aeruginosa (Engel et al., 1998).
Cleavage site specificity	Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern	-/ap/p/R-/-/al/- (based on 11 cleavages)

Specificity matrix

Amino acid	P4	P3	P2	P1	P1'	P2'	P3'	P4'
Gly	1	0	1	0	1	0	1	0
Pro	1	3	3	0	0	2	1	1
Ala	2	4	2	0	2	1	4	2
Val	2	0	0	0	0	2	0	3
Leu	2	1	2	0	0	1	3	1
Ile	0	0	0	0	0	2	0	0
Met	0	1	0	0	0	0	0	0
Phe	2	0	0	0	0	0	0	0
Tyr	0	0	0	0	0	1	0	0
Trp	0	0	0	0	0	0	0	0
Ser	0	1	0	0	2	0	1	2
Thr	0	0	2	0	1	1	0	0
Cys	0	0	1	0	0	0	0	0
Asn	0	0	0	0	0	0	0	1
Gln	0	0	0	0	1	0	1	0
Asp	0	0	0	0	0	0	0	0
Glu	0	0	0	0	1	0	0	1
Lys	0	1	0	2	3	0	0	0
Arg	1	0	0	9	0	1	0	0
His	0	0	0	0	0	0	0	0