$VAR1 = undef;

Summary for peptidase S01.071: kallikrein 1-related peptidase b9 (Mus musculus)

Names
MEROPS Name	kallikrein 1-related peptidase b9 (Mus musculus)
Other names	epidermal growth factor binding protein 3 (Mus musculus), epidermal growth factor binding protein C (Mus musculus), kallikrein mK9 (Mus musculus), Klk1b9 g.p. (Mus musculus), mK9, Klk9 [obs.] g.p. (Mus musculus), PRCE C, prorenin-converting enzyme C, kallikrein 9 (Mus musculus)

Domain architecture

MEROPS Classification
Classification	Clan PA >> Subclan PA(S) >> Family S1 >> Subfamily A >> S01.071
Holotype	kallikrein 1-related peptidase b9 (Mus musculus), Uniprot accession P15949 (peptidase unit: 37-272), MERNUM MER0000101
History	Identifier created: MEROPS 5.3 (4 December 2000)

Activity
Catalytic type	Serine
NC-IUBMB	Not yet included in IUBMB recommendations.
Proteolytic events	CutDB database (5 cleavages)
Physiology	Processes precursor of epidermal growth factor. Also generates kinin from kininogen, and plasmin from plasminogen.
Other databases	PANTHER	http://www.pantherdb.org/panther/familyList.do?searchType=basic&fieldName=all&listType=6&fieldValue=PTHR43890:SF10
Cleavage site specificity	Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern	-/-/k/R-/-/-/- (based on 14 cleavages)

Specificity matrix

Amino acid	P4	P3	P2	P1	P1'	P2'	P3'	P4'
Gly	0	0	0	0	0	0	1	1
Pro	0	1	0	0	0	1	1	1
Ala	0	0	1	0	0	1	0	0
Val	0	0	1	0	1	1	0	1
Leu	0	2	2	0	0	0	2	0
Ile	0	0	0	0	0	0	0	0
Met	0	1	0	0	0	0	0	0
Phe	2	0	1	0	0	0	0	0
Tyr	0	0	0	0	0	1	1	1
Trp	1	0	0	0	0	0	0	0
Ser	1	0	0	0	2	2	0	1
Thr	0	2	0	0	0	0	1	1
Cys	0	0	0	0	0	0	0	0
Asn	0	0	0	0	1	0	0	0
Gln	0	1	0	0	0	0	0	0
Asp	0	0	1	0	0	0	0	0
Glu	1	3	0	0	0	0	0	0
Lys	0	0	5	1	0	0	0	0
Arg	1	1	1	13	1	0	0	0
His	1	0	0	0	1	0	0	0

Mouse genetics
Gene symbol	Position	Megabases	Ensembl	Entrez gene	MGI
Klk9	7:B2		ENSMUSG00000048950	13648	MGI:95293