$VAR1 = undef;

Summary for peptidase M41.006: paraplegin

Names
MEROPS Name	paraplegin
Other names	spastic paraplegia gene 7, SPG7 g.p. (Homo sapiens)

Domain architecture

MEROPS Classification
Classification	Clan MA >> Subclan MA(D) >> Family M41 >> Subfamily (none) >> M41.006
Holotype	paraplegin (Homo sapiens), Uniprot accession Q9UQ90 (peptidase unit: 522-795), MERNUM MER0004454
History	Identifier created: MEROPS 3.03 (10 September 1998)

Activity
Catalytic type	Metallo
NC-IUBMB	Not yet included in IUBMB recommendations.
Activity status	human: putative mouse: putative
Knockout	Mutation of the human gene is responsible for an autosomal recessive form of hereditary spastic paraplegia (Pearce et al., 1999).
Pharmaceutical relevance	Work with mice has indicated that gene transfer may be an effective therapeutic option for patients with paraplegin deficiency (Pirozzi et al., 2005).
Other databases	TREEFAM	http://www.treefam.org/family/TF105003