$VAR1 = undef;

Summary for peptidase M12.164: lebetase

Summary Alignment Tree Sequences Sequence features Distribution Literature Substrates

 

Names
MEROPS Namelebetase
Other namesVipera lebetina venom metalloendopeptidase
Domain architecture
MEROPS Classification
Classification Clan MA >> Subclan MA(M) >> Family M12 >> Subfamily B >> M12.164
Holotypelebetase (Macrovipera lebetina), Uniprot accession Q98995 (peptidase unit: 195-397), MERNUM MER0002591
History Identifier created: MEROPS 3.02 (25 June 1998)
Activity
Catalytic typeMetallo
NC-IUBMBNot yet included in IUBMB recommendations.
Proteolytic eventsCutDB database (8 cleavages)
PhysiologyLikely role in snake venom toxicity.
Cleavage site specificity Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage patterng/-/-/pScissile bondl/r/-/- (based on 14 cleavages)
weblogo
Specificity matrix
 
Amino acid P4 P3 P2 P1 P1' P2' P3' P4'
Gly 5 0 1 2 0 0 2 2
Pro 1 2 0 6 0 1 0 0
Ala 0 1 1 1 1 0 0 0
Val 0 1 1 0 0 3 1 3
Leu 1 0 1 0 6 2 2 1
Ile 0 0 0 0 0 0 0 0
Met 0 0 0 0 1 1 0 0
Phe 1 4 1 0 2 0 1 1
Tyr 0 1 0 2 0 1 1 0
Trp 0 0 0 0 0 0 0 0
Ser 0 1 3 0 1 0 0 1
Thr 1 1 0 0 0 0 1 1
Cys 0 0 0 0 0 0 0 0
Asn 0 0 0 0 0 0 0 0
Gln 1 0 0 0 2 1 1 1
Asp 0 0 1 0 0 0 0 0
Glu 1 0 3 0 0 0 0 1
Lys 0 0 1 1 1 1 0 0
Arg 1 1 1 1 0 4 0 0
His 1 1 0 1 0 0 1 0