$VAR1 = undef;

Summary for peptidase M12.157: mucrolysin

Names
MEROPS Name	mucrolysin
Other names	mucrotoxin A, metalloendopeptidase TM-1 (Trimeresurus mucrosquamatus), metalloendopeptidase TM-2 (Trimeresurus mucrosquamatus), Trimeresurus mucrosquamatus venom metalloendopeptidase A, trimutase

Domain architecture

MEROPS Classification
Classification	Clan MA >> Subclan MA(M) >> Family M12 >> Subfamily B >> M12.157
Holotype	mucrolysin (Protobothrops mucrosquamatus), Uniprot accession O57413 (peptidase unit: 193-392), MERNUM MER0001135
History	Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.

Activity
Catalytic type	Metallo
NC-IUBMB	Subclass 3.4 (Peptidases) >> Sub-subclass 3.4.24 (Metalloendopeptidases) >> Peptidase 3.4.24.54
Enzymology	BRENDA database
Physiology	Likely role in snake venom toxicity.
Cleavage site specificity	Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern	-/-/-/gllyg/-/-/- (based on 14 cleavages)

Specificity matrix

Amino acid	P4	P3	P2	P1	P1'	P2'	P3'	P4'
Gly	0	1	1	4	2	0	0	1
Pro	0	0	0	0	1	0	0	0
Ala	0	1	1	2	0	0	0	1
Val	1	1	0	0	0	2	2	1
Leu	2	0	1	3	6	2	1	0
Ile	0	0	0	0	0	0	0	0
Met	0	0	0	0	1	0	0	0
Phe	0	0	0	0	0	0	0	0
Tyr	0	0	0	2	3	1	0	0
Trp	0	0	0	0	0	0	0	0
Ser	0	0	1	1	0	0	0	0
Thr	0	0	0	0	0	0	0	0
Cys	0	0	0	0	0	0	0	0
Asn	0	0	0	0	0	0	0	0
Gln	0	0	0	0	0	0	0	0
Asp	0	0	0	0	0	0	0	0
Glu	1	1	1	0	0	0	1	1
Lys	0	0	0	0	0	0	0	0
Arg	0	0	0	0	0	0	0	0
His	0	0	0	2	1	0	0	0