$VAR1 = undef;

Summary for peptidase M12.150: ruberlysin

Summary Alignment Tree Sequences Sequence features Distribution Literature Substrates

 

Names
MEROPS Nameruberlysin
Other namesCrotalus ruber (red rattlesnake) metalloendopeptidase II, hemorrhagic toxin II
Domain architecture
MEROPS Classification
Classification Clan MA >> Subclan MA(M) >> Family M12 >> Subfamily B >> M12.150
Holotyperuberlysin (Crotalus ruber), Uniprot accession P20897 (peptidase unit: 1-202), MERNUM MER0001124
History Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.
Activity
Catalytic typeMetallo
NC-IUBMBSubclass 3.4 (Peptidases) >> Sub-subclass 3.4.24 (Metalloendopeptidases) >> Peptidase 3.4.24.48
EnzymologyBRENDA database
Proteolytic eventsCutDB database (1 cleavage)
PhysiologyLikely role in snake venom toxicity. Hemorrhagic.
Other databases PANTHERhttp://www.pantherdb.org/panther/familyList.do?searchType=basic&fieldName=all&listType=6&fieldValue=PTHR11905:SF138
Cleavage site specificity Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage patternwy/ydi/h/gphwScissile bondFls/hmry/lp/gl (based on 16 cleavages)
weblogo
Specificity matrix
 
Amino acid P4 P3 P2 P1 P1' P2' P3' P4'
Gly 1 1 3 7 0 0 2 4
Pro 0 0 0 3 1 0 3 0
Ala 0 1 0 1 0 0 0 1
Val 1 1 0 0 0 2 0 1
Leu 1 0 1 0 6 0 4 3
Ile 0 3 1 0 0 0 0 0
Met 0 0 0 0 0 3 0 0
Phe 0 0 0 0 7 2 0 0
Tyr 3 4 3 1 0 3 1 0
Trp 3 0 0 2 0 0 0 0
Ser 0 0 1 0 2 0 0 0
Thr 0 0 0 0 0 0 0 1
Cys 0 0 0 0 0 0 0 0
Asn 0 0 0 0 0 0 0 0
Gln 0 0 0 0 0 0 0 0
Asp 0 3 0 0 0 0 0 0
Glu 1 1 1 0 0 0 1 0
Lys 0 0 0 0 0 0 0 0
Arg 0 0 1 0 0 3 0 0
His 0 0 5 2 0 3 1 0