$VAR1 = undef;

Summary for peptidase M09.003: bacterial collagenase H

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

 

Names
MEROPS Namebacterial collagenase H
Other namesbacterial collagenase, class II, colA g.p. (Bacillus cereus), colH g.p. (Clostridium histolyticum), microbial collagenase, class II
Domain architecture
MEROPS Classification
Classification Clan MA >> Subclan MA(E) >> Family M9 >> Subfamily B >> M09.003
Holotypebacterial collagenase H (Hathewaya histolytica) (peptidase unit: 88-529), MERNUM MER0001417
History Identifier created: MEROPS 5.0 (17 April 2000)
Activity
Catalytic typeMetallo
NC-IUBMBNot yet included in IUBMB recommendations.
InhibitorsNot trapped by alpha-2-macroglobulin (Barrett 1981).
Cleavage site specificity Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern-/G/pa/-Scissile bondGa/P/-/- (based on 246 cleavages)
weblogo
Specificity matrix
 
Amino acid P4 P3 P2 P1 P1' P2' P3' P4'
Gly 21 135 8 25 175 12 31 39
Pro 23 1 95 45 1 138 32 23
Ala 25 14 48 25 50 23 38 32
Val 17 9 5 9 0 2 15 8
Leu 20 2 13 36 0 6 32 15
Ile 5 4 2 0 0 1 20 9
Met 9 6 4 8 0 3 0 7
Phe 0 3 1 26 3 1 8 12
Tyr 3 4 1 15 0 3 6 3
Trp 3 2 1 10 0 0 2 0
Ser 34 13 8 7 8 14 16 9
Thr 11 0 7 5 1 3 16 11
Cys 2 1 1 2 0 2 2 2
Asn 3 0 7 7 1 6 1 12
Gln 11 2 7 11 0 24 8 13
Asp 6 0 1 2 3 1 4 5
Glu 15 0 2 3 0 1 7 14
Lys 8 14 5 0 1 4 0 2
Arg 7 20 4 0 1 0 3 3
His 5 1 11 5 2 2 4 9